||Fontes, Aparecida Maria; Kashima, Simone; Bonfim-Silva, Ricardo; Azevedo, Rochele; Abraham, Kuruvilla Joseph; Albuquerque, Sérgio Roberto Lopes; Bordin, José Orlando; Langhi Júnior, Dante Mário; Covas, Dimas Tadeu.|
||Association between Knops blood group polymorphisms and susceptibility to malaria in an endemic area of the Brazilian Amazon|
||Genet. mol. biol;34(4):539-545, 2011. tab.
||Fundação de Amparo à Pesquisa do Estado de São Paulo; . Conselho Nacional de Desenvolvimento Científico e Tecnológico; . USDA-NIFA.
||Complement receptor 1 (CR1) gene polymorphisms that are associated with Knops blood group antigens may influence the binding of Plasmodium parasites to erythrocytes, thereby affecting susceptibility to malaria. The aim of this study was to evaluate the genotype and allele and haplotype frequencies of single-nucleotide polymorphisms (SNPs) of Knops blood group antigens and examine their association with susceptibility to malaria in an endemic area of Brazil. One hundred and twenty-six individuals from the Brazilian Amazon were studied. The CR1-genomic fragment was amplified by PCR and six SNPs and haplotypes were identified after DNA sequence analysis. Allele and haplotype frequencies revealed that the Kn b allele and H8 haplotype were possibly associated with susceptibility to Plasmodium falciparum. The odds ratios were reasonably high, suggesting a potentially important association between two Knops blood antigens (Kn b and KAM+) that confer susceptibility to P. falciparum in individuals from the Brazilian Amazon.|
||Sistema ABO de Grupos Sanguíneos|
Características da População
Receptores de Complemento 3b
||BR1.1 - BIREME|