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Texto completo SciELO Brasil
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Id: biblio-839309
Autor: Xiao, Y; Deng, T; Shang, Z; Wang, D.
Título: Adiponectin inhibits oxidization-induced differentiation of T helper cells through inhibiting costimulatory CD40 and CD80
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;50(6):e6227, 2017. graf.
Idioma: en.
Projeto: Natural Science Foundation of Hubei Province.
Resumo: Adiponectin is a multifunctional adipokine that has several oligomeric forms in the blood stream, which broadly regulates innate and acquired immunity. Therefore, in this study, we aimed to observe the differentiation of T helper (Th) cells and expression of costimulatory signaling molecules affected by adiponectin. The mRNA and protein expression levels of adiponectin and its receptors in oxidized low density lipoprotein cholesterol-treated endothelial cells were assayed by real time PCR and immunofluorescence. The endothelial cells were then treated with adiponectin with or without adipoR1 or adipoR2 siRNA and co-cultured with T lymphocytes. The distribution of Th1, Th2 and Th17 subsets were assayed by flow cytometry. The effects of adiponectin on costimulatory signaling molecules HLA-DR, CD80, CD86 and CD 40 was also assayed by flow cytometry. The results showed that endothelial cells expressed adiponectin and its receptor adipoR1 and adipoR2, but not T-cadherin. Adiponectin suppressed Th1 and Th17 differentiation through adipoR1 receptor, contributed to the inhibition of CD80 and CD40, and inhibited differentiation of Th1 and Th17 by inhibiting antigen presenting action.
Descritores: Adiponectina/metabolismo
Antígeno B7-1/metabolismo
Antígenos CD40/metabolismo
Linfócitos T Auxiliares-Indutores/efeitos dos fármacos
-Adiponectina/genética
Adiponectina/farmacologia
Diferenciação Celular
Células Cultivadas
Células Endoteliais/efeitos dos fármacos
Células Endoteliais/metabolismo
Antígenos HLA-DR/metabolismo
Células Endoteliais da Veia Umbilical Humana/citologia
Lipoproteínas LDL/farmacologia
Receptores de Adiponectina/efeitos dos fármacos
Receptores de Adiponectina/metabolismo
Linfócitos T Auxiliares-Indutores/citologia
Linfócitos T Auxiliares-Indutores/metabolismo
Limites: Humanos
Recém-Nascido
Adulto
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
Montenegro, Sílvia M. L
Abath, Frederico G. C
Coutinho, Eridan M
Texto completo
Id: lil-295885
Autor: Montenegro, Silvia M. L; Abath, Frederico G. C; Domingues, Ana L. C; Melo, Wlademir; Morais, Clarice N. L de; Coutinho, Eridan M; Mahanty, Siddhartha; Wynn, Thomas.
Título: Preliminary results on the effects of CD40/CD40L interactions and SAC-induction on IFN-gamma expression in human schistosomiasis
Fonte: Mem. Inst. Oswaldo Cruz;96(suppl):103-105, Sept. 2001.
Idioma: en.
Resumo: In this communication the authors analyzed the pattern of expression of IFN-gamma as a surrogate type 1 response in different clinical forms of schistosomiasis in response to stimulation involving T-cell dependent and T-cell independent pathways, to investigate which pathways were functional in human schistosomiasis, and to further characterize the nature of Th1 response impairment in this parasitic disease
Descritores: Antígenos CD40/fisiologia
Ligante de CD40/fisiologia
Interferon gama/biossíntese
Esquistossomose mansoni/metabolismo
Staphylococcus aureus/fisiologia
-Antígenos CD40/metabolismo
Ligante de CD40/metabolismo
Esquistossomose mansoni/imunologia
Linfócitos T Auxiliares-Indutores/metabolismo
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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