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Pesquisa : D12.776.543.750.720.200.300 [Categoria DeCS]
Referências encontradas : 23 [refinar]
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  1 / 23 LILACS  
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Id: biblio-869669
Autor: Wang, Dian-Shi; Penna, Antonello; Orser, Beverley A.
Título: Ketamine increases the function of y-aminobutyric acid type a receptors in hippocampal and cortical neurons
Fonte: Rev. chil. anest;45(supl.1):S39-S39, 2016.
Idioma: en.
Conferência: Apresentado em: Congreso Chileno de Anestesiología, 44, Concepción, 17-19 nov. 2016.
Descritores: Hipocampo
Ketamina/metabolismo
Neurônios
Receptores de GABA/metabolismo
Limites: Seres Humanos
Responsável: CL1.1 - Biblioteca Central


  2 / 23 LILACS  
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Texto completo SciELO Brasil
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Id: lil-741537
Autor: Lacerda, Adriana; Quintiliano, Juliana; Lobato, Diolen; Gonçalves, Claudia; Marques, Jair.
Título: Hearing Profile of Brazilian Forestry Workers' Noise Exposure
Fonte: Int. arch. otorhinolaryngol. (Impr.);19(1):22-29, Jan-Mar/2015. tab, graf.
Idioma: en.
Resumo: Introduction Researchers studying the hearing health of forestry workers have revealed the presence of a noise-induced hearing loss (NIHL) in this population and have concluded that the vibration of the equipment, the carbon monoxide released by motors, and pesticides might also contribute to NIHL. Objective To analyze the noise exposure in the Brazilian forestry industry workers and the effects on hearing. Methods The study sample comprised 109 employees of a company that specialized in reforestation. Their participants' mean age was 35.5 years (21 to 54 years), mean tenure at the company was 3.9 years (1 to 13 years), and mean total duration of noise exposure was 12.3 years (1 to 30 years). The existing documentation reporting on the jobs risk analysis was examined, noise level was measured, and pure tone audiometry was performed in all participants. Participants were divided into three groups according to their noise exposure levels in their current job. Results Of the participants who were exposed to noise levels less than 85 dBA (decibels with A-weighting filter), 23.8% had hearing loss, and 5.5% of the participants who were exposed to noise ranging from 85 to 89.9 dBA and 11% of the participants who were exposed to noise greater than 90 dBA had audiogram results suggestive of NIHL. Conclusion The implementation of a hearing loss prevention program tailored to forestry workers is needed. .
Descritores: Geradores de Padrão Central/fisiologia
Respiração
Receptores de GABA/metabolismo
Receptores da Glicina/metabolismo
Limites: Animais
Tipo de Publ: Comentário
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  3 / 23 LILACS  
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Id: lil-682601
Autor: Baran, Halina; Kalina, Pavol; Wallner, Josef; Papst, Heide; Kepplinger, Berthold.
Título: Glutamate and GABA levels in the frontal cortex of rats with chronic epilepsy
Fonte: In: II International Congress on Neuroregeneration. Proceedings (selected papers). Rio de Janeiro, UFRJ, 2004. p.127-131, tab.
Idioma: en.
Conferência: Apresentado em: International Congress on Neuroregeneration, 2, Rio de Janeiro, 2004.
Resumo: Recently published data (Baran et al., Neurosignals 2004; 13: 290-7) have shown significantly increased activity of glutamic acid decarboxylase, the neuronal marker for gamma-aminobutyrate (GABA)-neurons, in the frontal cortex of rat brains, 6 months after kainic acid (KA) injection. In present study glutamate and GABA levels in the frontal cortex of rats in the KA (10 mg/kg, subcutaneously)-induced spontaneous recurrent seizure model of epilepsy, 6 months after the initial KA-induced seizures, were investigated. Six months after KA injection there was found a slightly reduced glutamate level in the frontal cortex (89.7 % of control), whereas the GABA level was moderately increased (119.6 % of control). The ratio GABA:glutamate level was significantly increased in the frontal cortex (134.5 % of control; P<0.001). Obtained data would indicate an enhancement of GABAergic activities in the frontal cortex in the chronic KA epileptic model. Interaction within GABAergic parameters, thus the GABAA receptors, the GABAB receptors, glutamate and GABA transporters may play a role in the modulation but also in the exertion of epileptic events in chronic KA epileptic model, which needs to be clarified.
Descritores: Epilepsia
Epilepsia do Lobo Temporal
Ácido gama-Aminobutírico
Glutamatos
Ácido Caínico
Neurologia
Fármacos Neuroprotetores
Córtex Pré-Frontal
Receptores de GABA
Receptores de Ácido Caínico
-Ratos
Ratos Sprague-Dawley
Limites: Animais
Ratos
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM
BR408.1; CD616.8, P963, 2004


  4 / 23 LILACS  
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Id: lil-670895
Autor: Brazilian Journal of Medical and Biological Research; Silva, G.A.P.; Kummerle, A.E.; Antunes, F.; Fraga, C.A.M.; Barreiro, E.J.; Zapata-Sudo, G.; Sudo, R.T..
Título: Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;46(3):263-269, 15/mar. 2013. graf.
Idioma: en.
Resumo: The N-acylhydrazone (NAH) analogues N-methyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-785) and N-benzyl 2-thienylidene 3,4-benzoylhydrazine (LASSBio-786) were prepared from 2-thienylidene 3,4-methylenedioxybenzoylhydrazine (LASSBio-294). The ability of LASSBio-785 and LASSBio-786 to decrease central nervous system activity was investigated in male Swiss mice. LASSBio-785 or LASSBio-786 (30 mg/kg, ip) reduced locomotor activity from 209 ± 26 (control) to 140 ± 18 (P < 0.05) or 146 ± 15 crossings/min (P < 0.05), respectively. LASSBio-785 (15 or 30 mg/kg, iv) also reduced locomotor activity from 200 ± 15 to 116 ± 29 (P < 0.05) or 60 ± 16 crossings/min (P < 0.01), respectively. Likewise, LASSBio-786 (15 or 30 mg/kg, iv) reduced locomotor activity from 200 ± 15 to 127 ± 10 (P < 0.01) or 96 ± 14 crossings/min (P < 0.01), respectively. Pretreatment with flumazenil (20 mg/kg, ip) prevented the locomotor impairment induced by NAH analogues (15 mg/kg, iv), providing evidence that the benzodiazepine (BDZ) receptor is involved. This finding was supported by the structural similarity of NAH analogues to midazolam. However, LASSBio-785 showed weak binding to the BDZ receptor. LASSBio-785 or LASSBio-786 (30 mg/kg, ip, n = 10) increased pentobarbital-induced sleeping time from 42 ± 5 (DMSO) to 66 ± 6 (P < 0.05) or 75 ± 4 min (P < 0.05), respectively. The dose required to achieve 50% hypnosis (HD50) following iv injection of LASSBio-785 or LASSBio-786 was 15.8 or 9.5 mg/kg, respectively. These data suggest that both NAH analogues might be useful for the development of new neuroactive drugs for the treatment of insomnia or for use in conjunction with general anesthesia.
Descritores: Hidrazinas/farmacologia
Hidrazonas/farmacologia
Hipnóticos e Sedativos/farmacologia
Atividade Motora/efeitos dos fármacos
Receptores de GABA/efeitos dos fármacos
Tiofenos/farmacologia
-Hidrazinas/química
Hidrazonas/química
Receptores de GABA/fisiologia
Tiofenos/química
Limites: Animais
Masculino
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  5 / 23 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: lil-665804
Autor: Dhakal, Radhika; Bajpai, Vivek K; Baek, Kwang-Hyun.
Título: Production of gaba (γ - aminobutyric acid) by microorganisms: a review
Fonte: Braz. j. microbiol;43(4):1230-1241, Oct.-Dec. 2012. ilus, tab.
Idioma: en.
Projeto: Systems and Synthetic Agro-biotech Center.
Resumo: GABA (γ-aminobutyric acid) is a four carbon non-protein amino acid that is widely distributed in plants, animals and microorganisms. As a metabolic product of plants and microorganisms produced by the decarboxylation of glutamic acid, GABA functions as an inhibitory neurotransmitter in the brain that directly affects the personality and the stress management. A wide range of traditional foods produced by microbial fermentation contain GABA, in which GABA is safe and eco-friendly, and also has the possibility of providing new health-benefited products enriched with GABA. Synthesis of GABA is catalyzed by glutamate decarboxylase, therefore, the optimal fermentation condition is mainly based on the biochemical properties of the enzyme. Major GABA producing microorganisms are lactic acid bacteria (LAB), which make food spoilage pathogens unable to grow and act as probiotics in the gastrointestinal tract. The major factors affecting the production of GABA by microbial fermentation are temperature, pH, fermentation time and different media additives, therefore, these factors are summarized to provide the most up-dated information for effective GABA synthesis. There has been a huge accumulation of knowledge on GABA application for human health accompanying with a demand on natural GABA supply. Only the GABA production by microorganisms can fulfill the demand with GABA-enriched health beneficial foods.
Descritores: Ácido gama-Aminobutírico/análise
Glutamato Descarboxilase/análise
Neurotransmissores
Receptores de GABA/análise
-Métodos
Estudos Retrospectivos
Tipo de Publ: Revisão
Responsável: BR32.1 - Serviço de Biblioteca e Informação Biomédica


  6 / 23 LILACS  
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Id: lil-556273
Autor: Hobaika, Adriano Bechara de Souza; Fantini, Cristiana Nunes Coelho; Figueiredo, Carolina Lamac; Santos, Pedro Ribeiro; Alves, Nilo Garonci.
Título: Monitorização dos níveis de consciência em anestesiologia / Consciousness level monitorization in anesthesia
Fonte: Rev. méd. Minas Gerais;17(1/2):54-59, jan.-jun. 2007. tab, ilus.
Idioma: pt.
Resumo: A anestesia geral é o conjunto de vários estados fisiológicos, incluindo o estado de inconsciência. O receptor do ácido gama-aminobutírico, subtipo A, tem se revelado importante alvo de drogas anestésicas, na medida em que contribuiu para indução de sedação e inconsciência. O anestesiologista deve ter conhecimento dos mecanismos de ação dos fármacos na transmissão do sistema gabaérgico e saber utilizar os meios disponíveis para monitorizar a consciência do paciente anestesiado. Nesse contexto, os aparelhos que processam os sinais do eletroencefalograma têm se mostrado muito úteis na motorização da inconsciência.
Descritores: Anestesia Geral
Estado de Consciência
-GABAérgicos
Eletroencefalografia
Monitorização Intraoperatória
Receptores de GABA
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR21.1 - Biblioteca J Baeta Vianna- Campus Saúde UFMG


  7 / 23 LILACS  
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Id: lil-403683
Autor: Brito, Vinicius Nahime de.
Título: Estudo do gene da subunidade alfa-1 do receptor tipo A do Estudo do gene da subunidade alfa-1 do receptor tipo A do ácido gama-aminobutírico (GABRA1) e avaliação eletroencefalográfica em meninas com puberdade precoce dependente de gonadotrofinas / Study of the gamma-aminobutyric acid type A receptor alpha-1 subunit gene (GABRA1) and electroencephalographic analysis in girls with gonadotropin-dependent precocious puberty.
Fonte: São Paulo; s.n; 2005. [75] p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Medicina para obtenção do grau de Doutor.
Resumo: O ácido gama-aminobutírico (GABA) está envolvido no mecanismo da puberdade. A subunidade alfa-1 do receptor GABAA, codificada pelo gene GABRA1 é implicada na atividade inibitória do GABA em neurônios de GnRH. Estudamos o GABRA1 em meninas com puberdade precoce dependente de gonadotrofinas idiopática. 31 meninas com puberdade precoce (19,4 por cento familiar) e 73 controles foram selecionados. 23 meninas (2 com epilepsia) realizaram eletroencefalograma e alterações foram vistas em 6 casos (26 por cento) indicando disfunção neurológica subclínica em 4 casos. Identificamos 7 polimorfismos no GABRA1 e mutações funcionais não foram identificadas. Alterações do GABRA1 provavelmente não estão envolvidas na etiologia da puberdade precoce nesta casuística / The gamma-aminobutyric acid (GABA) is involved in the mechanism of puberty. GABAA receptor subunit 1, encoded by GABRA1 gene is implicated in the inhibitory activity of the GABA on GnRH neurons. We studied GABRA1 in girls with idiopathic gonadotropin-dependent precocious puberty. 31 girls with precocious puberty (19.4 per cent familial) and 73 controls were selected. 23 girls (2 with epilepsy) were submitted to electroencephalogram (EEG). EEG revealed abnormalities in 6 patients (26 per cent) suggesting a subclinical neurological dysfunction in 4 cases. We identified 7 polymorphisms in GABRA1 and no functional mutations were identified. GABRA1 mutations or polymorphisms are not likely to be involved in precocious puberty etiology in this patients...
Descritores: Puberdade Precoce/etiologia
Receptores de GABA/genética
-Adolescente
Eletroencefalografia/métodos
Polimorfismo Genético
Mulheres
Limites: Seres Humanos
Feminino
Adolescente
Adulto
Responsável: BR66.1 - Divisão de Biblioteca e Documentação
BR66.1; W4.DB8, B877eg, FM-2


  8 / 23 LILACS  
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Id: lil-384013
Autor: Paladini, Alejandro C.
Título: Descubrimiento de nuevas sustancias activas en la ansiedad, el estrés y el sueño / Discovery of new active substances in the anxiety, stress and dream
Fonte: Bol. Acad. Nac. Med. B.Aires;80(2):265-279, jul.-dic. 2002. ilus, tab, graf.
Idioma: es.
Conferência: Apresentado em: Sesión Pública Ordinaria, Buenos Aires, 7 oct. 2002.
Descritores: Ansiedade
Benzodiazepinas
Hipnose Anestésica/métodos
Receptores de GABA
Estresse Fisiológico
Sono
Valeriana
-Experimentação Animal
Camundongos
Neurotransmissores
Plantas Medicinais
Responsável: AR1.1 - Biblioteca Rafael Herrera Vegas


  9 / 23 LILACS  
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Id: lil-319818
Autor: Donoso, A. O; Seltzer, A. M; Navarro, C. E; Cabrera, R. J; López, F. J; Negro-Vilar, A.
Título: Regulation of luteinizing hormone-releasing hormone and luteinizing hormone secretion by hypothalamic amino acids
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;27(4):921-932, Apr. 1994.
Idioma: en.
Resumo: 1. The present review discusses the proposed roles of the amino acids glutamate and GABA in the central regulation of luteinizing hormone-releasing hormone (LHRH) and in luteinizing hormone (LH) secretion. 2. Descriptions of the mechanisms of action of these neurotransmitters have focused on two diencephalic areas, namely, the preoptic-anterior hypothalamic area where the cell bodies of LHRH neurons are located, and the medial basal hypothalamus which contains the nerve endings of the LHRH system. Increasing endogenous GABA concentration by drugs, GABA agonists, or blockade of glutamatergic neurotransmission by selective antagonists in rats and non-human primates prevents ovulation and pulsatile LH release, and blunts the LH surges induced by estrogen or an estrogen-progesterone combination. In contrast, glutamate and different glutamate agonists such as NMDA, AMPA and kainate, can increase LHRH/LH secretion. 3. The simultaneous enhancement of glutamatergic activity and a decrease of GABAergic tone may positively influence the maturation of the pituitary-gonadal system in rats and non-human primates. Administration of glutamate receptor agonists has been shown to significantly advance the onset of puberty. Conversely, glutamate antagonists or increased endogenous GABA levels may delay the onset of puberty. The physiological regulation of LHRH/LH secretion may thus involve a GABA-glutamate interaction and a cooperative action of the various types of ionotropic glutamate receptors. 4. The inhibitory actions of GABA on LH release and ovulation may be exerted at the level of afferent nerve terminals that regulate LHRH secretion. A likely candidate is noradrenaline, as suggested by the synaptic connections between noradrenergic nerve terminals and GABAergic interneurons in the preoptic area. Recent experiments have provided complementary evidence for the physiological balance between inhibitory and excitatory transmission resulting in modulation of the action of noradrenaline to evoke LHRH release.
Descritores: Ácido gama-Aminobutírico/fisiologia
Glutamatos
Hormônio Liberador de Gonadotropina
Hipotálamo
Hormônio Luteinizante
-Ácido gama-Aminobutírico/farmacologia
Antagonistas de Aminoácidos Excitatórios
Antagonistas GABAérgicos
Glutamatos
Hormônio Liberador de Gonadotropina
Hipotálamo/efeitos dos fármacos
Hormônio Luteinizante
Norepinefrina
Receptores de GABA
Receptores de Glutamato
Maturidade Sexual
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR1.1 - BIREME


  10 / 23 LILACS  
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Texto completo SciELO Brasil
Silva, Ana Elizabete
Texto completo
Id: lil-309227
Autor: Silva, Ana Elizabete; Vayego-Lourenço, Sheila Adami; Fett-Conte, Agnes Cristina; Goloni-Bertollo, Eny Maria; Varella-Garcia, Marileila.
Título: Tetrasomy 15q11-q13 identified by fluorescence in situ hybridization in a patient with autistic disorder
Fonte: Arq. neuropsiquiatr;60(2A):290-294, June 2002. ilus.
Idioma: en.
Projeto: FUNDUNESP; . National Cancer Institute.
Resumo: We report a female child with tetrasomy of the 15q11-q13 chromosomal region, and autistic disorder associated with mental retardation, developmental problems and behavioral disorders. Combining classical and molecular cytogenetic approaches by fluorescence in situ hybridization technique, the karyotype was demonstrated as 47,XX,+mar.ish der(15)(D15Z1++,D15S11++,GABRB3++,PML-). Duplication of the 15q proximal segment represents the most consistent chromosomal abnormality reported in association with autism. The contribution of the GABA receptor subunit genes, and other genes mapped to this region, to the clinical symptoms of the disease is discussed
Descritores: Transtorno Autístico
Aberrações Cromossômicas
Cromossomos Humanos
Hibridização in Situ Fluorescente
-Cromossomos Humanos Par 11
Cromossomos Humanos Par 13
Cromossomos Humanos Par 15
Análise Citogenética
Cariotipagem
Receptores de GABA
Trissomia
Limites: Seres Humanos
Feminino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME



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