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Pesquisa : D12.776.543.750.792 [Categoria DeCS]
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Id: lil-402196
Autor: Holzhausen, M; Spolidorio, L. C; Vergnolle, N.
Título: Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
Fonte: Mem. Inst. Oswaldo Cruz;100(supl.1):177-180, Mar. 2005. ilus.
Idioma: en.
Resumo: Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.
Descritores: Periodontite/enzimologia
/fisiologia
RECEPTOR, PAR-TEMEFOS/fisiologia
Receptores Ativados por Proteinase/fisiologia
-Infecções por Bacteroidaceae/enzimologia
Inflamação/enzimologia
Inflamação/fisiopatologia
Porphyromonas gingivalis
Periodontite/fisiopatologia
Receptores Ativados por Proteinase/metabolismo
Limites: Seres Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Revisão
Responsável: BR1.1 - BIREME


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Id: lil-402195
Autor: Vergnolle, Nathalie.
Título: Protease-activated receptors and inflammatory hyperalgesia
Fonte: Mem. Inst. Oswaldo Cruz;100(supl.1):173-176, Mar. 2005. ilus.
Idioma: en.
Resumo: Recent advances in basic science pointed to a role for proteinases, through the activation of proteinase-activated receptors (PARs) in nociceptive mechanisms. Activation of PAR1, PAR2 and PAR4 either by proteinases or by selective agonists causes inflammation inducing most of the cardinal signs of inflammation: swelling, redness, and pain. Sub-inflammatory doses of PAR2 agonist still induced hyperalgesia and allodynia while PAR2 has been shown to be implicated in the generation of hyperalgesia in different inflammatory models. In contrast, sub-inflammatory doses of PAR1 increases nociceptive threshold, inhibiting inflammatory hyperalgesia, thereby acting as an analgesic agent. PARs are present and functional on sensory neurons, where they participate either directly or indirectly to the transmission and/or inhibition of nociceptive messages. Taken together, the results discussed in this review highlight proteinases as signaling molecules to sensory nerves. We need to consider proteinases and the receptors that are activated by proteinases as important potential targets for the development of analgesic drugs in the treatment of inflammatory pain.
Descritores: Hiperalgesia/enzimologia
Inflamação/enzimologia
Neurônios Aferentes/enzimologia
Receptores Ativados por Proteinase/fisiologia
-Hiperalgesia/fisiopatologia
Inflamação/fisiopatologia
Receptores Ativados por Proteinase/metabolismo
Limites: Animais
Seres Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME



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