Base de dados : LILACS
Pesquisa : D13.695.578 [Categoria DeCS]
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Id: lil-618054
Autor: Macêdo, D. S; Araújo, D. P; Sampaio, L. R. L; Vasconcelos, S. M. M; Sales, P. M. G; Sousa, F. C. F; Hallak, J. E; Crippa, J. A; Carvalho, A. F.
Título: Animal models of prenatal immune challenge and their contribution to the study of schizophrenia: a systematic review
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(3):179-186, Mar. 2012. ilus, tab.
Idioma: en.
Resumo: Prenatal immune challenge (PIC) in pregnant rodents produces offspring with abnormalities in behavior, histology, and gene expression that are reminiscent of schizophrenia and autism. Based on this, the goal of this article was to review the main contributions of PIC models, especially the one using the viral-mimetic particle polyriboinosinic-polyribocytidylic acid (poly-I:C), to the understanding of the etiology, biological basis and treatment of schizophrenia. This systematic review consisted of a search of available web databases (PubMed, SciELO, LILACS, PsycINFO, and ISI Web of Knowledge) for original studies published in the last 10 years (May 2001 to October 2011) concerning animal models of PIC, focusing on those using poly-I:C. The results showed that the PIC model with poly-I:C is able to mimic the prodrome and both the positive and negative/cognitive dimensions of schizophrenia, depending on the specific gestation time window of the immune challenge. The model resembles the neurobiology and etiology of schizophrenia and has good predictive value. In conclusion, this model is a robust tool for the identification of novel molecular targets during prenatal life, adolescence and adulthood that might contribute to the development of preventive and/or treatment strategies (targeting specific symptoms, i.e., positive or negative/cognitive) for this devastating mental disorder, also presenting biosafety as compared to viral infection models. One limitation of this model is the incapacity to model the full spectrum of immune responses normally induced by viral exposure.
Descritores: Modelos Animais de Doenças
Polinucleotídeos
Efeitos Tardios da Exposição Pré-Natal/imunologia
Esquizofrenia/imunologia
-Esquizofrenia/etiologia
Limites: Animais
Feminino
Camundongos
Gravidez
Ratos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: lil-63830
Autor: Castagnino, Juan Miguel.
Título: Electroforesis de proteínas: principios y evolución de las técnicas para su estudio / Electrophoresis of proteins: principles and evolution of the technics for its study
Fonte: Acta bioquím. clín. latinoam;22(1):33-49, mar. 1988. ilus.
Idioma: es.
Conferência: Apresentado em: Curso Internacional Sobre Proteinas Plasmáticas, 1, La Plata, 16-18 jul. 1987.
Descritores: Eletroforese das Proteínas Sanguíneas/métodos
Proteínas/análise
-Corantes
Eletroforese em Gel de Poliacrilamida
Imunoeletroforese
Focalização Isoelétrica
Misturas Anfolíticas
Polinucleotídeos/análise
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco



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