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Id: biblio-1046565
Autor: Moreno, Andréia de Haro; Possebon, Lucas; Sant'Anna, Moniele; Souza, Helena Ribeiro; Pilon, Melina Misuzaki Iomasa; Girol, Ana Paula.
Título: Avaliação da atividade antimicrobiana e citotoxicidade hemolítica em diferentes extratos vegetais / Evaluation of antimicrobial activity and hemolytic cytotoxicity in different plant extracts
Fonte: Arch. Health Sci. (Online);25(1):11-12, 23/04/2018.
Idioma: pt.
Resumo: Introdução: A busca por novos agentes terapêuticos tem incentivado as pesquisas com plantas medicinais, pois muitas delas podem apresentar propriedade antimicrobiana e conhecer o potencial citotóxico dos extratos é fundamental para garantir a segurança durante o uso. Objetivo: Avaliar a atividade antimicrobiana e a citotoxicidade hemolítica de Arctium lappa (bardana), Equisetum arvense (cavalinha), Mikania glomerata (guaco), Morus nigra (amora) e Plantago major (tanchagem), amplamente consumidos pela população na forma de chás medicinais. Material e Métodos: Os extratos etanólicos fora preparados a 20% por percolação. Na avaliação antimicrobiana foi utilizada a técnica de difusão em disco, empregando as bactérias Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Proteus mirabilis, Klebsiella pneumoniae, Acinetobactersp, Enterococcus sp e Salmonella sp. O ensaio de citotoxicidade baseou-se na exposição dos extratos a 5%, 25%, 50%, 75% e 100% em suspensão de hemácias a 37ºC por 30 minutos, seguido de centrifugação e visualização do grau de hemólise. Resultados: Todos os extratos apresentaram inibição de crescimento microbiano, principalmente sobre Acinetobacter sp (amora), Enterococcus sp (amora e cavalinha), K. pneumoniae(amora, bardana e guaco), P. aeruginosa (cavalinha, tanchagem, bardana e guaco) e Salmonellasp (amora e bardana). No ensaio de citotoxicidade, o grau de hemólise foi classificado como baixo para tanchagem e bardana (5%) e médio para cavalinha, guaco e amora (25%) nas concentrações testadas. Conclusão: Os resultados mostram o potencial antimicrobiano dos extratos de amora, bardana, cavalinha, guaco e tanchagem contra bactérias Gram negativas e a baixa citotoxicidade hemolítica confirma a segurança no uso dos mesmos como agentes terapêuticos.
Descritores: Extratos Vegetais/análise
Antibacterianos
Noxas/análise
Responsável: BR13.3 - Biblioteca das Faculdades de Odontologia e Nutrição


  2 / 2312 LILACS  
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Id: biblio-959211
Autor: Berlowitz, Ilana; Ghasarian, Christian; Walt, Heinrich; Mendive, Fernando; Alvarado, Vanessa; Martin-Soelch, Chantal.
Título: Conceptions and practices of an integrative treatment for substance use disorders involving Amazonian medicine: traditional healers' perspectives
Fonte: Rev. bras. psiquiatr;40(2):200-209, Apr.-June 2018. tab, graf.
Idioma: en.
Projeto: Swiss National Science Foundation.
Resumo: Objective: The harmful use of psychoactive substances represents one of today's largest public health problems. Yet, in spite of its global relevance, current treatment for substance use disorders (SUDs) is still not entirely successful. The purpose of this study was to investigate alternative treatments and conceptions from traditional Amazonian medicine adapted to SUDs. Methods: We conducted semi-structured interviews with 13 practicing experts at a well-established addiction treatment center in the Peruvian Amazon and performed qualitative content analysis on the collected data. Main categories were deductively defined and corresponding subcategories inductively developed. Results: Our findings revealed characteristic features and consequences, causes and antecedents, and treatment methods of SUDs as the main categories. Overall, concepts of disease etiology bore resemblance with contemporary biopsychosocial models of SUDs. The Amazonian therapeutic means however differed markedly from current Western ones. The main methods involved dietary retreats, healing ceremonies, and purging rituals. The integral application of Amazonian methods, as well as their traditional implementation according to prescribed ritual protocols, were emphasized by the experts as crucial for efficacy and safety of treatment delivery. Conclusion: We suggest further scientific attention to these therapies, including clinical studies, for which our results provide conceptual underpinnings. Findings from this research expand the cross-cultural understanding of SUDs and, in the long run, may enhance its treatment options.
Descritores: Extratos Vegetais/uso terapêutico
Transtornos Relacionados ao Uso de Substâncias/tratamento farmacológico
Fitoterapia
-Peru
Plantas Medicinais
Terapias Complementares
Entrevistas como Assunto
Floresta Úmida
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


  3 / 2312 LILACS  
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Quevedo, Joäo
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Id: biblio-959251
Autor: Valvassori, Samira S; Borges, Cenita; Bavaresco, Daniela V; Varela, Roger B; Resende, Wilson R; Peterle, Bruna R; Arent, Camila; Budni, Josiane; Quevedo, João.
Título: Hypericum perforatum chronic treatment affects cognitive parameters and brain neurotrophic factor levels
Fonte: Rev. bras. psiquiatr;40(4):367-375, Oct.-Dec. 2018. graf.
Idioma: en.
Resumo: Objective: To evaluate the effects of Hypericum perforatum (hypericum) on cognitive behavior and neurotrophic factor levels in the brain of male and female rats. Methods: Male and female Wistar rats were treated with hypericum or water during 28 days by gavage. The animals were then subjected to the open-field test, novel object recognition and step-down inhibitory avoidance test. Nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and glial cell-line derived neurotrophic factor (GDNF) levels were evaluated in the hippocampus and frontal cortex. Results: Hypericum impaired the acquisition of short- and long-term aversive memory in male rats, evaluated in the inhibitory avoidance test. Female rats had no immediate memory acquisition and decreased short-term memory acquisition in the inhibitory avoidance test. Hypericum also decreased the recognition index of male rats in the object recognition test. Female rats did not recognize the new object in either the short-term or the long-term memory tasks. Hypericum decreased BDNF in the hippocampus of male and female rats. Hypericum also decreased NGF in the hippocampus of female rats. Conclusions: The long-term administration of hypericum appears to cause significant cognitive impairment in rats, possibly through a reduction in the levels of neurotrophic factors. This effect was more expressive in females than in males.
Descritores: Extratos Vegetais/farmacologia
Cognição/efeitos dos fármacos
Hypericum
Lobo Frontal/metabolismo
Hipocampo/metabolismo
Fatores de Crescimento Neural/análise
-Extratos Vegetais/administração & dosagem
Distribuição Aleatória
Fatores Sexuais
Resultado do Tratamento
Ratos Wistar
Modelos Animais
Reconhecimento Fisiológico de Modelo/efeitos dos fármacos
Relação Dose-Resposta a Droga
Lobo Frontal/efeitos dos fármacos
Hipocampo/efeitos dos fármacos
Locomoção/efeitos dos fármacos
Memória/efeitos dos fármacos
Fatores de Crescimento Neural/efeitos dos fármacos
Limites: Animais
Masculino
Feminino
Responsável: BR1.1 - BIREME


  4 / 2312 LILACS  
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Id: biblio-1054685
Autor: Hou, Bao; Cai, Weiwei; Chen, Ting; Zhang, Zhixuan; Gong, Haifeng; Yang, Wei; Qiu, Liying.
Título: Vaccarin hastens wound healing by promoting angiogenesis via activation of MAPK/ERK and PI3K/AKT signaling pathways in vivo
Fonte: Acta cir. bras;34(12):e201901202, 2019. graf.
Idioma: en.
Projeto: Wuxi Science and Technology Development Fund 2018; . Jiangnan University Youth Fund 2018.
Resumo: Abstract Purpose To explore the potential role and unclear molecular mechanisms of vaccarin in wound healing. Methods Rats' skin excision model to study the effects of vaccarin on wound healing in vivo . Hematoxylin and eosin staining was performed to evaluate Histopathologic characteristics. Immunohistochemistry was employed to assess the effects of vaccarin in accelerating angiogenesis. Western blot was used to evaluate relative protein expressed levels. Results Vaccarin could significantly promote wound healing and endothelial cells and fibroblasts proliferation in the wound site. Immunohistochemistry and Western blot studies showed that the nodal proteins and receptor (bFGFR) related to angiogenesis signaling pathway were activated, and the microvascular density in the wound site was markedly higher than that in the control group. Conclusions The present study was the first to demonstrate that vaccarin is able to induce angiogenesis and accelerate wound healing in vivo by increasing expressions of p-Akt, p-Erk and p-bFGFR. This process is mediated by MAPK/ERK and PI3K/AKT signaling pathways.
Descritores: Cicatrização/efeitos dos fármacos
Extratos Vegetais/farmacologia
Fosfatidilinositol 3-Quinases/efeitos dos fármacos
Quinases de Proteína Quinase Ativadas por Mitógeno/efeitos dos fármacos
Caryophyllaceae/química
Indutores da Angiogênese/farmacologia
-Fatores de Tempo
Imuno-Histoquímica
Extratos Vegetais/química
Transdução de Sinais
Western Blotting
Reprodutibilidade dos Testes
Ratos Sprague-Dawley
Fosfatidilinositol 3-Quinases/análise
Quinases de Proteína Quinase Ativadas por Mitógeno/análise
Células Endoteliais/efeitos dos fármacos
Proliferação de Células/efeitos dos fármacos
Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/análise
Receptor Tipo 1 de Fator de Crescimento de Fibroblastos/efeitos dos fármacos
Fibroblastos/efeitos dos fármacos
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1054675
Autor: Rocha, Keyla Borges Ferreira; Oliveira, Cláudia Nunes; Azevedo, Ítalo Medeiros; Macedo, Robson de; Medeiros, Aldo Cunha.
Título: Effect of Arrabidaea chica extract against chemically induced breast cancer in animal model
Fonte: Acta cir. bras;34(10):e201901001, Oct. 2019. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: Abstract Purpose: To examine the effects of Arrabidaa chica (Bignoniacea) extract, a native plant of the Amazon known as crajiru, on a 7,12-dimethyl-1,2-benzanthracene (DMBA)-induced breast cancer model in Wistar rats. Methods: We compared the response of breast cancer to the oral administration of A. chica extract (ACE) for 16 weeks, associated or not with vincristine. Groups: normal control; DMBA (50mg/kg v.o,) without treatment; DMBA+ACE (300 mg/kg); DMBA+vincristine. 500μg/kg injected i.p; DMBA+ACE+Vincristine 250μg/kg i.p. Imaging by microPET and fluorescence, biochemistry, oxidative stress, hematology and histopathology were used to validate the treatments. Results: All animals survived. A gradual weight gain in all groups was observed, with no significant difference (p>0.05). The oral administration of ACE and ACE+vincristine 50% significantly reduced breast tumors incidence examined with PET-18FDG and fluorescence (p<0.001). Significant reduction of serum transaminases, oxidative stress and hematological toxicity were observed in these groups. Antioxidant enzyme levels in breast tissue were significantly higher compared to the DMBA and DMBA+vincristine groups. Conclusion: These results demonstrate for the first time that ACE positively influences the treatment of DMBA-induced breast cancer in animal model, inducing a reduction in oxidative stress and chemotherapy toxicity, meaning that ACE may have clinical implication in further studies.
Descritores: Neoplasias da Mama/tratamento farmacológico
Extratos Vegetais/farmacologia
Carcinoma/tratamento farmacológico
Bignoniaceae/química
Neoplasias Experimentais/tratamento farmacológico
Antineoplásicos/farmacologia
-Vincristina/farmacologia
Neoplasias da Mama/patologia
Neoplasias da Mama/diagnóstico por imagem
Carcinógenos
Carcinoma/patologia
Carcinoma/diagnóstico por imagem
Catalase/análise
Resultado do Tratamento
Ratos Wistar
Fluordesoxiglucose F18
9,10-Dimetil-1,2-benzantraceno
Glutationa Peroxidase/análise
Antineoplásicos/uso terapêutico
Limites: Animais
Feminino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-886240
Autor: Estevão, Lígia Reis Moura; Simões, Ricardo Santos; Cassini-Vieira, Puebla; Canesso, Maria Cecilia Campos; Barcelos, Lucíola da Silva; Rachid, Milene Alvarenga; Câmara, Cláudio Augusto Gomes da; Evêncio-Neto, Joaquim.
Título: Schinus terebinthifolius Raddi ( Aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice
Fonte: Acta cir. bras;32(9):726-735, Sept. 2017. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigated the inflammatory, angiogenic and fibrogenic activities of the Schinus terebinthifolius Raddi leaves oil (STRO) on wound healing. Methods: The excisional wound healing model was used to evaluate the effects of STRO. The mice were divided into two groups: Control, subjected to vehicle solution (ointment lanolin/vaseline base), or STRO- treated group, administered topically once a day for 3, 7 and 14 days post-excision. We evaluated the macroscopic wound closure rate; the inflammation was evaluated by leukocytes accumulation and cytokine levels in the wounds. The accumulation of neutrophil and macrophages in the wounds were determined by assaying myeloperoxidase and N-acetyl-β-D-glucosaminidase activities. The levels of TNF-α, CXCL-1 and CCL-2 in wound were evaluated by ELISA assay. Angiogenesis and collagen fibers deposition were evaluated histologically. Results: We observed that macroscopic wound closure rate was improved in wounds from STRO-group than Control-group. The wounds treated with STRO promoted a reduction in leucocyte accumulation and in pro-inflammatory cytokine. Moreover, STRO treatment increased significantly the number of blood vessels and collagen fibers deposition, as compared to control group. Conclusion: Topical application of STRO display anti-inflammatory and angiogenic effects, as well as improvement in collagen replacement, suggesting a putative use of this herb for the development of phytomedicines to treat inflammatory diseases, including wound healing.
Descritores: Cicatrização/efeitos dos fármacos
Óleos Vegetais/uso terapêutico
Extratos Vegetais/uso terapêutico
Anacardiaceae/química
Indutores da Angiogênese/uso terapêutico
Inflamação/tratamento farmacológico
-Fatores de Tempo
Imuno-Histoquímica
Colágeno/análise
Folhas de Planta/química
Tela Subcutânea/efeitos dos fármacos
Tela Subcutânea/patologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  7 / 2312 LILACS  
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Rizzo, José Angelo
Solé, Dirceu
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Id: biblio-830735
Autor: Peixoto, Décio Medeiros; Rizzo, José Angelo; Schor, Deborah; Silva, Almerinda Rêgo; Oliveira, Dinaldo Cavalcanti de; Solé, Dirceu; Sarinho, Emanuel.
Título: Use of honey associated with Ananas comosus (Bromelin) in the treatment of acute irritative cough / Uso do mel de abelha associado ao Ananas comosus (Bromelin) no tratamento da tosse irritativa aguda
Fonte: Rev. paul. pediatr;34(4):412-417, Oct.-Dec. 2016. tab.
Idioma: en.
Resumo: Abstract Objective: To evaluate the immediate improvement rate of irritative cough in patients treated with the combination of Ananas comosus extract and honey (Bromelin®) compared with the use of honey alone (placebo group). Methods: Pragmatic, double-blind, randomized, parallel-group study with children aged between 2 and 15 years, with irritative cough for at least 24hours. The double-blind assessment of cough was through the number of observed coughing episodes and intensity score for a period of 10minutes of observation. The decrease of one point in the mean total score was considered as a therapeutic effect. Results: There was a reduction in coughing episodes in both groups, as well as in the cough score after 30minutes of drug or honey administration. The change in clinical score above two points, which could indicate marked improvement, occurred in five patients in the bromelin group and only in one in the placebo group, but without significant difference. There were no adverse events. Conclusions: The immediate improvement rate of irritative cough was similar in patients treated with combination of Ananas comosus extract and honey (Bromelin®) compared with the use of honey alone (placebo group). It is possible that honey has a therapeutic effect on mucus and cough characteristics (Clinical Trials: NCT01356693).

Resumo Objetivo: Avaliar a taxa de melhoria imediata da tosse irritativa em pacientes tratados com associação do extrato do Ananas comosus em mel de abelha (Bromelin®) e compará-la com a de uso do mel isolado (grupo placebo). Métodos: Estudo pragmático da vida real, duplo-cego, randômico, de grupos paralelos, em crianças, entre dois e 15 anos, com tosse irritativa havia pelo menos 24 horas. A avaliação da tosse foi duplo-cega foi feita por meio da avaliação do número de episódios observáveis e do escore de intensidade de tosse durante o período de 10 minutos de observação. A redução de um ponto na média do escore total foi considerada como efeito terapêutico. Resultados: Em ambos os grupos houve redução do número de episódios de tosse, assim como do escore de tosse após 30 minutos de administração do medicamento ou do mel. A mudança de escore clínico superior a dois, que poderia indicar melhoria acentuada, ocorreu em cinco pacientes do grupo com bromelina e em apenas um do placebo, mas sem diferença significante. Não ocorreram eventos adversos. Conclusões: A taxa de melhoria imediata da tosse irritativa foi similar entre pacientes tratados com associação do extrato do Ananas comosus em mel de abelha (Bromelin®) e com o uso do mel isolado (grupo placebo). É possível que haja um efeito terapêutico do mel nas características do muco e da tosse (Clinical Trials: NCT01356693).
Descritores: Extratos Vegetais/uso terapêutico
Tosse/terapia
Ananas
Mel
Fitoterapia
-Método Duplo-Cego
Doença Aguda
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Ensaio Clínico Pragmático
Responsável: BR1.1 - BIREME


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Id: biblio-886257
Autor: Goret, Ceren Canbey; Goret, Nuri Emrah; Kiraz, Asli; Ozkan, Omer Faruk; Karaayvaz, Muammer.
Título: The effect of pycnogenol on lymphatic nodes and adhesion during in a peritoneal adhesion model in rats
Fonte: Acta cir. bras;33(2):134-143, Feb. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effects of pycnogenol on peritoneal adhesions and additionally to investigate the immunohistochemical effects of free oxygen radicals and reactive lymph nodes detected in the adhesive tissue that was sampled surrounding the cecum on intra-abdominal adhesions. Methods: Twenty-seven Wistar Albino rats were divided into three groups. In group 1 (sham), laparotomy was performed and stitched up. In group 2 (control), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered 2 cc of saline. In group 3 (experimental), after laparotomy was performed, punctate hemorrhage was induced by cecal abrasion in the cecum and each rat was intraperitoneally administered a sterile Pycnogenol derivative. The rats in all groups were re-laparotomized on postoperative day 7; samples were obtained from the peritoneal tissue surrounding the cecum, and the rats were sacrificed. Results: In group 3, there was a statistically significant difference in terms of inflammation, lymph node size, and free oxygen radicals; these parameters tended to increase. In terms of fibrosis evaluated using H&E and MT, there was no significant difference between groups 2 and 3. Conclusions: No positive outcomes indicating that pycnogenol reduces intra-abdominal adhesions were obtained. However, it caused severe inflammation in the tissue. Moreover, a significant increase in lymph node size was detected secondary to inflammation. Additionally, in immunohistochemical analyses conducted to detect oxidative stress, pycnogenol increased the production of free oxygen radicals in the tissue.
Descritores: Doenças Peritoneais/prevenção & controle
Peritônio/cirurgia
Flavonoides/uso terapêutico
Aderências Teciduais/prevenção & controle
-Doenças Peritoneais/etiologia
Peritônio/patologia
Complicações Pós-Operatórias
Flavonoides/efeitos adversos
Imuno-Histoquímica
Extratos Vegetais
Aderências Teciduais/etiologia
Aderências Teciduais/patologia
Espécies Reativas de Oxigênio/metabolismo
Ratos Wistar
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais de Doenças
Radicais Livres/análise
Inflamação/induzido quimicamente
Inflamação/patologia
Laparotomia
Linfonodos/efeitos dos fármacos
Linfonodos/patologia
Anti-Inflamatórios/uso terapêutico
Antioxidantes/uso terapêutico
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


  9 / 2312 LILACS  
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Id: biblio-989071
Autor: Souza Neto Júnior, José de Castro; Estevão, Lígia Reis de Moura; Ferraz, Adriana Aparecida; Simões, Ricardo Santos; Vieira, Marcela Gabriela Feitosa; Evêncio-Neto, Joaquim.
Título: Ointment of Ximenes americana promotes acceleration of wound healing in rats
Fonte: Acta cir. bras;34(3):e201900307, 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the healing potential of the Ximenia americana hydroalcoholic extract in 10% cream in excisional wound models in rats. Methods: Sixty male adults Wistar rats were submitted to skin and subcutaneous tissue surgery in the right and left thoracic regions, divided into three experimental groups: Standard submitted to treatment with only the base vehicle, Treated wounds treated with hydroalcoholic extract of X. americana applied on 10%, Lanette base and Control, untreated wounds. The treatment was performed daily and the wounds evaluated microscopically by the quantification of fibroblasts, collagen fibers and blood vessels. Results: The histomorphometric analysis showed a significant increase in the number of fibroblasts, collagen fibers and blood vessels in the treated group. Conclusion: The topical action of the cream based on Ximenia americana shows angiogenic effects and improves the replacement of collagen, suggesting its use for the development of herbal remedy in the treatment of cutaneous wound healing.
Descritores: Cicatrização/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Olacaceae/química
-Pomadas
Ratos Wistar
Modelos Animais de Doenças
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  10 / 2312 LILACS  
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Id: biblio-989062
Autor: Mammadov, Renad; Suleyman, Bahadir; Altuner, Durdu; Demirci, Elif; Cetin, Nihal; Yilmaz, Adnan; Baykal, Huseyin; Alpcan, Hilal; Turumtay, Emine Akyuz; Suleyman, Halis.
Título: Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Fonte: Acta cir. bras;34(3):e201900305, 2019. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.
Descritores: Neoplasias Gástricas/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Adenocarcinoma/tratamento farmacológico
Usnea/química
Acetatos/uso terapêutico
Antineoplásicos Fitogênicos/uso terapêutico
-Ratos Wistar
Neoplasias Experimentais/tratamento farmacológico
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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