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Pesquisa : D20.215.784.500 [Categoria DeCS]
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Id: lil-796000
Autor: Brandão, Marcelo Luiz; Reis, Paulo Roberto Melo; Araújo, Lilhian Alves de; Araújo, Ana Carolina Vicente; Santos, Maisa Helena de Abreu Silva; Miguel, Marina Pacheco.
Título: Evaluation of wound healing treated with latex derived from rubber trees and Aloe Vera extract in rats
Fonte: Acta cir. bras;31(9):570-577, Sept. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To compare the use of latex derivative and Aloe vera extract to wound healing. METHODS: Twenty one rats were randomly divided into three groups and each one had a wound made by incision. The treatment consisted in: derivative of latex (GL), Aloe vera extract (GA) and saline solution (GC). The wound area was measured on the 7th, 14th and 21st days and macroscopic and microscopic evaluation were done. RESULTS: The comparison between the measurements of the wounds presented statistical difference in GC and GA from the 7th day of evaluation and GL from the 14th day. The extent of the wound was significantly smaller by the 7th day in GL. Histologically, in GL, the neovascularization was significant on the 7th, 14th and 21st days. On the 21st day the scar was large and little mature. In GA and GC, the findings were similar on the 7th, 14th and 21st days with a slight better organization of skin and collagen on the 21st in GA. CONCLUSIONS: Statistical analysis did not allow for the definition of the best topical agent. The latex had the highest angiogenesis, but a possible foreign body granuloma. Aloe vera has revealed a healing process adequated temporally in histology.
Descritores: Cicatrização/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Hevea/química
Aloe/química
Látex/uso terapêutico
Fitoterapia
-Cloreto de Sódio/administração & dosagem
Distribuição Aleatória
Ratos Wistar
Avaliação Pré-Clínica de Medicamentos
Látex/química
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  2 / 2282 LILACS  
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Lima, Sonia Oliveira
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Id: lil-795998
Autor: Figueiredo, Maria Bernadete Galrão de Almeida; Santana, Vanessa Rocha de; Nardelli, Maria Júlia; Nogueira, Matheus de Souza; Azevedo, Danilo Xavier; Santana, Danillo Primo Andrade; Figueiredo, Ana Galrão de Almeida; Duarte, Ívison Xavier; Albuquerque Junior, Ricardo Luiz Cavalcanti de; Lima, Sônia Oliveira.
Título: The effect of the aqueous extract Peumus boldus on the proliferation of hepatocytes and liver function in rats submitted to expanded hepatectomy
Fonte: Acta cir. bras;31(9):608-614, Sept. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To assess the effect of aqueous extract of Peumus Boldus (AEPB) on the liver proliferative response after parcial hepatectomy of 70% (PH) in rodents. METHODS: Twenty Wistar rats were divided in two groups: AEPB100 (whose rats received 100mg/Kg of AEPB, once a day, orally, in 4 days prior to the first surgical procedure) and Vehicle (whose rats were treated similarly with distilled water). Both groups underwent PH. After 24 hours the remaining livers were removed for studying the proliferation of hepatocytes by Ki-67 and 2mL of blood were collected for serological assessment: cholesterol, glucose, triglycerides, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and total, direct and indirect bilirubin. All data were analyzed by Gaussian distribution. Statistically significant differences between mean values were analyzed using T Student's test. Non-Gaussian data were analyzed using Mann-Whitney's test. RESULTS: The liver of all these rats presented positive staining of Ki-67, indicating liver proliferation. Laboratory results showed no significant difference in serum values between the analyzed groups. The analysis of Ki-67 was significantly more positive in AEPB100 group than in Vehicle group. CONCLUSION: Aqueous extract of Peumus Boldus acute administration exerts significant positive effect on liver regeneration after 24h in rats that underwent parcial hepatectomy, while maintaining unchanged hepatic function.
Descritores: Extratos Vegetais/farmacologia
Hepatócitos/efeitos dos fármacos
Peumus/química
Hepatectomia/métodos
Fígado/fisiologia
Regeneração Hepática/efeitos dos fármacos
-Ratos Wistar
Folhas de Planta/química
Hepatócitos/metabolismo
Modelos Animais de Doenças
Fígado/efeitos dos fármacos
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


  3 / 2282 LILACS  
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Id: lil-795995
Autor: Nascimento, Vitor Hugo Nunes do; Lima, Carla dos Santos; Paixão, Jorge Tadeu Campos; Freitas, Jofre Jacob da Silva; Kietzer, Katia Simone.
Título: Antioxidant effects of açaí seed ( Euterpe oleracea ) in anorexia-cachexia syndrome induced by Walker-256 tumor
Fonte: Acta cir. bras;31(9):597-601, Sept. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To assess antioxidant effects of açaí seed extract on anorexia-cachexia induced by Walker-256 tumor. METHODS: A population of 20 lab rats were distributed into four groups (n=5): Control Group (CG), which only received tumor inoculation. Experimental Group-100 (EG-100), with animals submitted to tumor inoculation and treated with seed extract in a 100 mg / ml concentration through gavage. Experimental Group-200 (EG-200), with animals submitted to tumor inoculation and treated with seed extract in a 200 mg / ml concentration. Placebo Group (GP), which received tumor inoculation and ethanol-water solution. We analyzed proteolysis, lipid peroxidation, tumor diameter and weight. RESULTS: Lipid peroxidation was representative only in the cerebral cortex, where there was more oxidative stress in rats treated with the extract (p = 0.0276). For proteolysis, there was less muscle damage in untreated rats (p = 0.0312). Only tumor diameter in treated rats was significantly lower (p = 0.0200) compared to untreated ones. CONCLUSIONS: The açaí seed extract showed no beneficial effect on the general framework of the cachectic syndrome in lab rats. However, some anticarcinogenic effects were observed in the tumor diameter and weight.
Descritores: Sementes/química
Caquexia/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Anorexia/tratamento farmacológico
Euterpe/química
Antioxidantes/farmacologia
-Síndrome
Caquexia/etiologia
Extratos Vegetais/farmacologia
Carcinoma 256 de Walker/complicações
Peroxidação de Lipídeos/efeitos dos fármacos
Anorexia/etiologia
Córtex Cerebral/enzimologia
Análise de Variância
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Ratos Wistar
Estresse Oxidativo/efeitos dos fármacos
Neoplasias Experimentais/complicações
Antioxidantes/análise
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  4 / 2282 LILACS  
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Id: lil-792410
Autor: Baracho, Nilo César do Vale; Monteiro, Natália Fechus; Borges, Manuela Guedes; Arguelho, Raíssa Robles de Moura.
Título: Effect of aqueous extract of the Vigna angularis in rats subjected to an experimental model of moderate chronic kidney disease
Fonte: Acta cir. bras;31(8):527-532, Aug. 2016. graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effect of the aqueous extract of the Vigna angularis, popularly known as "Azuki beans", in rats subjected to an experimental model of moderate chronic kidney disease. METHODS: Thirty rats underwent two surgeries - Ormrod and Miller (1980) - to obtain Moderate Chronic Kidney Disease (CKD-M). The animals were randomized into 3 groups. Group 1 (Control): distilled water. Group 2 (Azuki): Vigna angularis 5% aqueous extract. Group 3 (Treatment): 10mg/kg of enalapril maleate. The rats received their respective treatments for 14 days. RESULTS: The treatment with azuki beans produced an increase in urine output from the second day until the end of the experiment compared to the Control groups (p<0.01) and Treatment (p<0.05). The treatment with azuki also produced significant reductions in the levels of glucose, triglycerides, VLDL, uric acid, Alanine aminotransferase (p<0.05), urea and serum creatinine (p<0.01), besides having produced a significant increase in the levels of HDL when compared to the Control group. CONCLUSION: Treatment with Azuki beans produced improvements in the parameters of renal function and significantly reduced glucose levels, triglycerides, VLDL, alanine aminostransferase, uric acid and creatinine, besides having produced a significant increase in the levels of HDL in rats submitted to a model of moderate chronic kidney disease.
Descritores: Extratos Vegetais/uso terapêutico
Insuficiência Renal Crônica/tratamento farmacológico
Vigna/química
Fitoterapia
-Triglicerídeos/sangue
Ureia/sangue
Distribuição Aleatória
Ratos Wistar
Creatinina/sangue
Avaliação Pré-Clínica de Medicamentos
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  5 / 2282 LILACS  
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Id: lil-792409
Autor: Zhang, Jing; Shen, Juan; Yin, Weiwei; Wei, Xiaoyu; Wu, Ligao; Liu, Hao.
Título: The intervention research on treatment by Xianchen to rabbits model of chemotherapeutic phlebitis
Fonte: Acta cir. bras;31(8):549-556, Aug. 2016. tab, graf.
Idioma: en.
Projeto: Natural Science Foundation of Anhui; . Innovation Plan of Bengbu Medical College.
Resumo: ABSTRACT PURPOSE: To develop a chemotherapeutics induced phlebitis and explore the effects of Xianchen on the phlebitis treatment. METHODS: Forty-eight rabbits were divided into two series. Phlebitis model induced by vincristine was established at each series. The first series had 24 rabbits, which were divided into four groups (6 hours, 12 hours, 18 hours, 24 hours) after vincristine infusion. The grades of phlebitis through visual observation and histopathological examination were observed. The second series had also 24 rabbits. Interventions were performed 12 hours after vincristine infusion. These rabbits were randomly divided into four groups, according to treatment: Hirudoid (bid), Xianchen (daily), Xianchen (tid), Xianchen (five times a day). Four days after intervention, the venous injury through visual observation and histopathological examination were evaluated. RESULTS: Series 1: Phlebitis appeared 12 hours after infusion of vincristine through visual observation. There was a significant difference (p<0.05) between 6 hours and 24 hours, 6 hours and 18 hours through visual observation. However, the inflammation happened 6 hours after infusion, the loss of venous endothelial cells demonstrated differences among four groups through histopathological evaluation (p<0.05). There were significant differences (p<0.05) after 4 days among the intervention groups through visual observation, the effects of Xianchen group (five times a day) were better than Xianchen group (tid) (p<0.01). The treatment of edema demonstrated differences among groups through histopathological evaluation (p<0.05), Xianchen (five times a day) better relieved the degree of edema (p<0.05). CONCLUSIONS: The study showed that inflammatory reaction of phlebitis appeared early. Xianchen can treat vincristine induced phlebitis, as well as Hirudoid. It is particularly effective in the treatment of edema, and there is a remarkable dose-response relationship.
Descritores: Flebite/tratamento farmacológico
Medicamentos de Ervas Chinesas/administração & dosagem
Extratos Vegetais/administração & dosagem
Edema/tratamento farmacológico
Fitoterapia/métodos
Anti-Inflamatórios/administração & dosagem
-Flebite/induzido quimicamente
Flebite/prevenção & controle
Vincristina
Infusões Intravenosas
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Medicina Tradicional Chinesa/métodos
Limites: Animais
Coelhos
Responsável: BR1.1 - BIREME


  6 / 2282 LILACS  
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Czeczko, Nicolau Gregori
Malafaia, Osvaldo
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Id: lil-785021
Autor: Scheibe, Christian Lamar; Ribas-Filho, Jurandir Marcondes; Czeczko, Nicolau Gregori; Malafaia, Osvaldo; Barboza, Luiz Eduardo Durães; Ribas, Fernanda Marcondes; Wendler, Eduardo; Torres, Orlando; Lovato, Fernanda Christo; Scapini, João Guilherme Seifert.
Título: Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats
Fonte: Acta cir. bras;31(6):402-410tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effect of Schinus terebinthifolius Raddi (aroeira) and Orbignya phalerata Mart. (babassu) in the healing process of cecorrhaphy in rats. METHODS : Fifty four rats were used, distributed into three groups randomly: aroeira, babassu and control, which were divided into three subgroups (six animals) according to the time of the deaths (7, 14, 21 days). All underwent the same surgical procedure, cecotomy and cecorrhaphy. The animals in group aroeira and babassu received daily dose of 100 mg/kg of hydroalcoholic extract and 50 mg/kg of aquous extract respectively, by gavage. The control group received only saline solution. The parameters evaluated were: macroscopic changes, ,resistance test to air insufflations and histological changes. RESULTS : All animals showed good healing without infection. All groups presented adhesions between cecum and neighboring organs. The resistance test insufflating of atmospheric air showed progressive increase of pressure according to the days in the aroeira group, and decrease in babassu group, without significant difference. Microscopy showed significant difference in the polymorphonuclear, hyperemia, angiogenesis, fibroblast proliferation and collagen histological variables in the 14th day. CONCLUSION : Hydroalcoholic extract of aroeira and the aqueous extract of babassu favored the healing process in cecorrhaphy in rats.
Descritores: Extratos Vegetais/farmacologia
Ceco/cirurgia
Anacardiaceae
Arecaceae
Fitoterapia
Anti-Inflamatórios/farmacologia
-Período Pós-Operatório
Distribuição Aleatória
Doenças do Ceco/prevenção & controle
Aderências Teciduais
Aderências Teciduais/etiologia
Ratos Wistar
Modelos Animais
Neutrófilos/efeitos dos fármacos
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  7 / 2282 LILACS  
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Id: lil-785013
Autor: Takhtfooladi, Mohammad Ashrafzadeh; Asghari, Ahmad; Hoseinzadeh, Hesam aldin; Mokhtari, Farahnaz.
Título: Effect of Otostegia persica extract on ischemia/reperfusion induced renal damage in diabetic rats. A biochemical study
Fonte: Acta cir. bras;31(6):417-421tab.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effect of Otostegia persica (O. persica) extract on renal damage induced by ischemia/reperfusion (I/R) in diabetic rats. METHODS: Forty-eight rats were subjected to right nephrectomy; then, they were allocated into six groups: Sham; Diabetic sham; I/R; Diabetic I/R; I/R+O. persica; Diabetic I/R+O. persica. Diabetes was induced by streptozotocin (200 mg/kg, i.p.). O. persica (300 mg/kg/day, p.o) was administered for 2 weeks. On the 15th day, ischemia was induced in left kidney for 60 min, followed by reperfusion for 24h. Renal functional and biochemical markers were estimated. RESULTS: I/R in both normal and diabetic rats, induced a significant elevation in serum levels of urea and creatinine (p<0.05). Renal I/R induced a significant increase of malondialdehyde, myeloperoxidase and nitric oxide concentrations associated with significant reduction in superoxide dismutase and catalase activities in comparison with the sham group (p<0.05). Diabetic rats that underwent renal I/R exhibited a significant increase in all the studied parameters with a reduction in the antioxidant enzymes as compared to nondiabetic rats (p<0.05). These deleterious effects associated with renal I/R were improved by the treatment with O. persica (p<0.05). CONCLUSION: Otostegia persica pretreatment protected the renal injury from ischemia-reperfusion in diabetic rats.
Descritores: Extratos Vegetais/farmacologia
Traumatismo por Reperfusão/complicações
Lamiaceae
Diabetes Mellitus Experimental/complicações
Antioxidantes/farmacologia
-Superóxido Dismutase/metabolismo
Ureia/sangue
Glicemia/efeitos dos fármacos
Traumatismo por Reperfusão/metabolismo
Catalase/metabolismo
Ratos Wistar
Peroxidase/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Creatinina/sangue
Modelos Animais
Hipoglicemiantes/farmacologia
Rim/efeitos dos fármacos
Peróxidos Lipídicos/metabolismo
Nefrectomia/efeitos adversos
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  8 / 2282 LILACS  
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Id: biblio-1048605
Autor: Ahmadi, Asghar; Salehi, Ali; Dadmehr, Aliakbar; Ghodarzi, Sara; Sadighara, Parisa; Samarghandian, Saeed; Farkhondeh, Tahereh.
Título: The effect of banana leaf package on the shelf life of rainbow trout fillet in comparison with plastic bag s / O efeito da embalagem de folha de bananeira na vida de prateleira do filé de truta arco-íris em comparação com sacos de plástico
Fonte: Biosci. j. (Online);35(2):503-508, mar./apr. 2019. tab.
Idioma: en.
Resumo: The aim of this study was to evaluate the effect of banana leaf extract on the quality and shelf life of rainbow trout compared to plastic bags at freezing temperature for 40 days. For evaluating this propose, the antioxidant activity of banana leaf extract was assessed. In addition, the shelf life of fish filets was determined by measuring thiobarbituric acid (TBA) and pHof fish. The banana leaves extract showed the highest content of vitamin E (5.8 ± 0.61 mg /g) and carotenoids (12.8 ± 0.1 mg /g). The potential of Cu (II) reduction the extract was 1.76 ± 0.09. The magnitude of modification in TBA and pH of the packed fish with banana leaves were less than the control samples. The present study demonstrated that the use of banana leaf extract will retard lipid oxidation in fish. fillet during freezing storage that may due to its strong antioxidant properties.

O objetivo deste estudo foi avaliar o efeito do extrato de folhas de bananeira sobre a qualidade e vida de prateleira da truta arco-íris comparada a sacolas plásticas na temperatura de congelamento por 40 dias. Para avaliar essa proposta, foi determinada a atividade antioxidante do extrato de folhas de bananeira. Além disso, a vida de prateleira dos filés de peixe foi determinada medindo o ácido tiobarbitúrico (TBA) e o pH do peixe. O extrato de folhas de bananeira apresentou o maior teor de vitamina E (5,8 ± 0,61 mg/g) e carotenóides (12,8 ± 0,1 mg/g). O potencial de redução de Cu (II) no extrato foi de 1,76 ± 0,09. A magnitude da modificação no TBA e pH do peixe embalado com folhas de bananeira foi menor que as amostras controle. O presente estudo demonstrou que o uso de extrato de folhas de bananeira é capaz de retardar a oxidação lipídica no filé de peixe durante o armazenamento de congelamento, devido às suas fortes propriedades antioxidantes.
Descritores: Extratos Vegetais
Oncorhynchus mykiss
Musa
Prazo de Validade de Produtos
Antioxidantes
-Embalagem de Produtos
Congelamento
Responsável: BR396.1 - Biblioteca Central


  9 / 2282 LILACS  
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Id: lil-778496
Autor: Bezerra, Andréia Gomes; Negri, Giuseppina; Duarte-Almeida, Joaquim Maurício; Smaili, Soraya Soubhi; Carlini, Elisaldo Araújo.
Título: Phytochemical analysis of hydroethanolic extract of Turnera diffusa Willd and evaluation of its effects on astrocyte cell death / Análise fitoquímica do extrato hidroetanólico de Turnera diffusa Willd e avaliação de seus efeitos na morte de astrócitos
Fonte: Einstein (Säo Paulo);14(1):56-63, Jan.-Mar. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective To evaluate the phytochemical composition of hydroethanolic extracts from powdered aerial parts of Turnera diffusa Willd (Turneraceae; T. diffusa), as well as its toxicity in astrocytes. Methods Chemical analyses of hydroethanolic extract from powdered aerial parts ofT. diffusa were carried out using HPLC-DAD-ESI-MS/MS.In vitro assays using astrocytes culture were performed to evaluate cell death. Results Flavone-C, O-diglycosides, such as, luteolin-8-C-[6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside, apigenin-8-C-[6-deoxy-2-O-rhamnosyl]-xylo-hexos-3-uloside and apigenin-7-O-6”-p-coumaroylglucoside were the main compounds found in this hydroethanolic extract. Concentration time-effect demonstrated the toxicity of this extract at a concentration of 1,000µg/mL in astrocyte culture, after 6 and 24 hours of incubation. Conclusion In phytochemical analyses, important antioxidants (mainly flavonoids) were observed. T. diffusa extracts presented cytotoxic effect in high concentrations, leading to increased cell death in astrocyte culture.

RESUMO Objetivo Avaliar a composição fitoquímica do extrato hidroetanólico das partes aéreas de Turnera diffusa Willd (Turneraceae; T. diffusa) e sua toxicidade em astrócitos. Métodos Análises químicas do extrato hidroetanólico de partes aéreas de T. diffusa foram feitas por HPLC-DAD-ESI-MS/MS. Os ensaiosin vitro utilizaram culturas de astrócitos para avaliar morte celular. Resultados Flavonas-C, O-diglicosídeos, como, luteolina-8-C-[6-deoxi-2-O-raminosil]-xilo-hexos-3-ulosideo, apigenina-8-C-[6-deoxi-2-O-raminosil]-xilo-hexos-3-ulosideo e apigenina-7-O-6”-p-cumaroilglucosídeo foram os principais constituintes encontrados neste extrato hidroetanólico. Uma curva tempo-concentração demonstrou toxicidade desse extrato na concentração de 1.000µg/mL, na cultura de astrócitos após 6 e 24 horas de incubação. Conclusão Nas análises fitoquímicas, importantes antioxidantes, sobretudo flavonoides, foram observados. Extratos de T. diffusa apresentaram efeitos citotóxicos em altas concentrações, ocasionando aumento de morte celular em cultura de astrócitos.
Descritores: Extratos Vegetais/química
Astrócitos/efeitos dos fármacos
Turnera/química
Antioxidantes/química
-Extratos Vegetais/toxicidade
Astrócitos/química
Cromatografia Líquida de Alta Pressão/métodos
Morte Celular/efeitos dos fármacos
Espectrometria de Massas por Ionização por Electrospray/métodos
Flavonas/análise
Flavonas/toxicidade
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


  10 / 2282 LILACS  
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Amorim, Elias
Malafaia, Osvaldo
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Id: lil-781328
Autor: Amorim, Elias; Saad Junior, Roberto; Salgado Filho, Natalino; Melo, George Castro Figueira de; Silva, Gyl Eanes Barros; Santos, Rennan Abud Pinheiro; Marchi, Danilo Dallago de; Carli, Ricardo Comunello de; Malafaia, Osvaldo; Ribas-Filho, Jurandir.
Título: The effects of aqueous extract of babassu (Orbignya phalerata) on the pleura and lung parenchyma in rats
Fonte: Acta cir. bras;31(4):243-249, Apr. 2016. tab.
Idioma: en.
Resumo: PURPOSE: To evaluate macro and microscopically, changes following the use of the aqueous extract of babassu (Orbignya phalerata) in the lung parenchyma and pleura of rats. METHODS: Sixty adult male rats with average weight of 350 g, were randomized into two groups of 30 animals (experimental and control) further divided into sub-groups of 10 to be sacrificed at 48 h, 72 h and 21 days. The substance was injected into the right pleura of the animals. RESULTS: There was intense pleuropulmonary macroscopic reaction with statistically significant differences between groups respectively (p<0.05, p<0.02, p<0.03). Microscopically, no statistically significant difference was evident (p>0.05). CONCLUSION: The aqueous extract of babassu (Orbignya phalerata) was found to be highly irritating to the pleura and lung of rats, evidenced macroscopically by numerous adhesions and inflammation while no major changes were evident microscopically.
Descritores: Pleura/efeitos dos fármacos
Extratos Vegetais/farmacologia
Pleurodese/métodos
Arecaceae/química
Pulmão/efeitos dos fármacos
-Pleura/patologia
Pneumonia/induzido quimicamente
Fatores de Tempo
Cicatrização
Distribuição Aleatória
Reprodutibilidade dos Testes
Modelos Animais de Doenças
Pulmão/patologia
Anti-Inflamatórios/farmacologia
Limites: Animais
Masculino
Ratos
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME



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