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Id: biblio-1284403
Autor: Baharuddin, Aifaa Akmal; Roosli, Rushduddin Al Jufri; Zakaria, Zainul Amiruddin; Tohid, Siti Farah Md.
Título: Dicranopteris linearis: a potential medicinal plant with anticancer properties / Dicranopteris linearis: una planta medicinal potencial con propiedades anticancerígenas
Fonte: Bol. latinoam. Caribe plantas med. aromát;20(1):28-37, 2021. ilus, tab.
Idioma: en.
Projeto: Ministry of Higher Education Malaysia.
Resumo: Several investigations have demonstrated Dicranopteris linearis (Burm.f.) Underw. (Gleicheniaceae) plant extracts possess numerous health-promoting properties. This review is aimed to summarize and highlight the potential possess by D. linearisto be developed into future pharmacological entity especially as anticancer agent. This study used several electronic search engines to compile and integrate a number of scientific publications related with D. linearis. Scientifically, D. linearishas been reported to have antinociceptive, anti-inflammatory, antipyretic, chemopreventive and antioxidant properties which can be linked to its potential to treat various kinds of ailments including inflammatory-related diseases and cancer. A number of scientific evidences related with anticancer studies suggested the ability of D. linearis-based phytochemicals to act as potent anticancer lead compounds. In conclusion, D. linearis has the potential to be developed into potent anticancer agent as depicted by a number of isolated phytochemicals which can work synergistically to contribute to its anticancer properties.

Varias investigaciones han demostrado que los extractos de la planta Dicranopteris linearis (Burm.f.) Underw. (Gleicheniaceae) poseen numerosas propiedades promotoras de la salud. El objetivo de esta revisión es resumir y resaltar el potencial que posee D. linearispara convertirse en una entidad farmacológica futura, especialmente como agente anticancerígeno. Este estudio utilizó varios motores de búsqueda electrónicos para compilar e integrar una serie de publicaciones científicas relacionadas con D. linearis. Científicamente, se ha informado que D. linearis tiene propiedades antinociceptivas, antiinflamatorias, antipiréticas, quimiopreventivas y antioxidantes que pueden estar vinculadas a su potencial para tratar varios tipos de dolencias, incluidas las enfermedades asociadas a inflamación y el cáncer. Una serie de evidencias científicas relacionadas con los estudios anticancerosos sugirieron la capacidad de los fitoquímicos basados en D. linearis para actuar como potentes compuestos anticancerígenos. En conclusión, D. linearis tiene el potencial de convertirse en una fuente de potentes agentes anticancerígeno, como se describe en una serie de fitoquímicos aislados que pueden actuar de forma sinérgica para contribuir a sus propiedades anticancerígenas.
Descritores: Plantas Medicinais
Extratos Vegetais/uso terapêutico
Traqueófitas/química
Antineoplásicos/uso terapêutico
-Extratos Vegetais/química
Compostos Fitoquímicos
Antineoplásicos/química
Antioxidantes
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1091448
Autor: Almaguer-Flores, Argelia; González-Alva, Patricia.
Título: Antibacterial Activity of Homeopathic Medications Lycopodium clavatum and Arsenicum album Against Periodontal Bacteria / Evaluación antibacteriana de los medicamentos homeopáticos sobre bacterias periodontales
Fonte: Odovtos (En línea);20(2):71-79, May.-Aug. 2018. tab.
Idioma: en.
Resumo: Abstract There are several controversies regarding the efficacy of homeopathic substances; however, these remedies are used in many countries for the treatment of various pathological conditions. The purpose of this study was to evaluate the in vitro antibacterial activity of two homeopathic tinctures Arsenicum album (mineral extract) and Lycopodium clavatum (plant extract) on the periodontal bacteria Actinomyces israelii, Streptococcus sanguinis, Prevotella intermedia, Aggregatibacter actinomycetemcomitans and Phorphyromonas gingivalis (P. gingivalis). Materials and methods: Equal numbers of bacteria were seeded on agar plates containing enriched media with the homeopathic solutions at 1dH and 1cH dilutions. After 7 days of incubation under anaerobic conditions, colony forming units (CFUs) were counted. The antibacterial effect was calculated based on the total number of CFUs observed on non-tincture containing agar, and on the tincture containing plates. Results: No visible growth of any of the strains was observed on the plates containing Arsenicum album at any of the dilutions tested. In contrast, when Lycopodium clavatum at 1cH dilution was tested, only P. gingivalis was susceptible to this compound. Conclusions: The results suggest that the mineral extract tincture had a greater antibacterial activity than the plant extract tincture, also Lycopodium clavatum preparation could be an effective inhibitor of periodontal pathogens bacteria such as P. gingivalis.

Resumen Se necesita un mayor número de estudios in vitro e in vivo para validar estos resultados.
Descritores: Streptococcus sanguis/efeitos dos fármacos
Actinomyces/efeitos dos fármacos
Arsenicum Album/antagonistas & inibidores
Lycopodium clavatum/antagonistas & inibidores
Aggregatibacter actinomycetemcomitans/efeitos dos fármacos
Porphyromonas gingivalis/efeitos dos fármacos
Prevotella intermedia/efeitos dos fármacos
-Extratos Vegetais/análise
Ação Farmacodinâmica do Medicamento Homeopático
Homeopatia
Tipo de Publ: Estudo Comparativo
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Id: biblio-1249171
Autor: Amparo, Tatiane Roquete; Rodrigues, Ivanildes Vasconcelos; Seibert, Janaína Brandão; Almeida, Tamires Cunha; Cabral, Vivette Appolinário Rodrigues; Vieira, Paula Melo de Abreu; Brandão, Geraldo Célio; Oliveira, Mauro Lúcio Gonçalves de; Silva, Glenda Nicioli da; Santos, Orlando David Henrique dos; Vieira Filho, Sidney Augusto; Teixeira, Luiz Fernando Medeiros; Souza, Gustavo Henrique Bianco de.
Título: Antibacterial substances from leaves of Protium spruceanum (Burseraceae): in vitro and in silico evaluation
Fonte: Braz. J. Pharm. Sci. (Online);56:e18474, 2020. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa de Minas Gerais.
Resumo: Due to the increase of bacterial resistance, the search for new antibiotics is necessary and the medicinal plants represent its most important source. The aim of this study was to evaluate the antibacterial property of extract and fractions from Protium spruceanum leaves, against pathogenic bacteria. By means of diffusion and microdilution assays, the crude extract was active against the nine bacteria tested being the hydromethanolic fraction the most active. During phytochemical procedures, procyanidin (1) and catechin (2) were identified as the main antibacterial constituents of this fraction. In silico results obtained using PASSonline tool indicated 1 and 2 as having good potential to interact with different targets of currently used antibiotics. These results no indicated potential to none DNA effect and indicated the cell wall as mainly target. Electrophoresis result supported that had no DNA damage. Cell wall damage was confirmed by propidium iodide test that showed increased membrane permeability and by cell surface deformations observed in scanning electronic microscopy. The in vitro assays together with the in silico prediction results establish the potential of P. spruceanum as source of antibacterial compounds that acts on important bacterial targets. These results contribute to the development of natural substances against pathogenic bacteria and to discovery of new antibiotics.
Descritores: Plantas Medicinais/efeitos adversos
Técnicas In Vitro/métodos
Extratos Vegetais/análise
Catequina
Antibacterianos/análise
-Simulação por Computador
Microscopia Eletrônica de Varredura/métodos
Folhas de Planta/classificação
Burseraceae/classificação
Compostos Fitoquímicos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1055379
Autor: Hussein, Elsayed Alsaied Masoud; Mohammad, Ali Al-Hajry; Harraz, Farid Abourageh; Ahsan, Mohd Faisal.
Título: Biologically Synthesized Silver Nanoparticles for Enhancing Tetracycline Activity Against Staphylococcus aureus and Klebsiella pneumoniae
Fonte: Braz. arch. biol. technol;62:e19180266, 2019. tab, graf.
Idioma: en.
Projeto: Deanship of Scientific Research, Najran University.
Resumo: Abstract Phytochemical content of plant extracts can be used effectively to reduce the metal ions to nanoparticles in one-step green synthesis process. In this study, six plant extracts were used for the synthesis of silver nanoparticles (AgNPs). Biologically synthesized AgNPs was characterized using UV-Vis Spectrophotometer, Field Emission Scanning Electron Microscope (FE-SEM), X-ray diffraction (XRD), Energy Dispersive X-ray spectroscopy (EDX) and Fourier Transform Infrared (FTIR) spectroscopy. The individual and combined effects of AgNPs and tetracycline against S. aureus and K. pneumoniae were assessed. Ginger, onion and sidr extracts supported AgNPs formation while arak, garlic and mint extracts failed to convert the silver ions to AgNPs. The present findings revealed significant differences between the tested plant extracts in supporting AgNPs synthesis. AgNPs synthesized by ginger showed the highest individual and combined activity against tested strains followed by AgNPs prepared by sidr then that synthesized by onion. AgNPs significantly enhanced tetracycline activity (p≤0.05) against S. aureus and K. pneumoniae. The results of this study demonstrated that the combination of tetracycline and biologically synthesized AgNPs presented a useful therapeutically method for the treatment of bacterial infection and counterattacking bacterial resistance.
Descritores: Prata/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Tetraciclina/biossíntese
Extratos Vegetais/biossíntese
Klebsiella pneumoniae/efeitos dos fármacos
-Espectrometria por Raios X/instrumentação
Difração de Raios X/instrumentação
Espectrofotômetros/métodos
Espectroscopia de Infravermelho com Transformada de Fourier/instrumentação
Responsável: BR1.1 - BIREME


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Coelho, Humberto Eustáquio
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Id: biblio-1012003
Autor: Magalhães, Fernanda Oliveira; Uber-Bucek, Elizabeth; Ceron, Patricia Ibler Bernardo; Name, Thiago Fellipe; Coelho, Humberto Eustáquio; Barbosa, Claudio Henrique Gonçalves; Carvalho, Tatiane; Groppo, Milton.
Título: Chronic treatment with hydroalcoholic extract of Plathymenia reticulata promotes islet hyperplasia and improves glycemic control in diabetic rats / Tratamento crônico com extrato hidroalcoólico de Plathymenia reticulata promove hiperplasia de ilhotas e controle glicêmico em ratos diabéticos
Fonte: Einstein (Säo Paulo);17(3):eAO4635, 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objective: To investigate the anti-hyperglycemic effects of Plathymenia reticulata hydroalcoholic extract and related changes in body weight, lipid profile and the pancreas. Methods: Diabetes was induced in 75 adult male Wistar rats via oral gavage of 65mg/Kg of streptozotocin. Rats were allocated to one of 8 groups, as follows: diabetic and control rats treated with water, diabetic and control rats treated with 100mg/kg or 200mg/kg of plant extract, and diabetic and control rats treated with glyburide. Treatment consisted of oral gavage for 30 days. Blood glucose levels and body weight were measured weekly. Animals were sacrificed and lipid profile and pancreatic tissue samples analyzed. Statistical analysis consisted of ANOVA, post-hoc Tukey-Kramer, paired Student's t and χ2 tests; the level of significance was set at 5%. Results: Extract gavage at 100mg/kg led to a decrease in blood glucose levels in diabetic rats in the second, third (198.71±65.27 versus 428.00±15.25) and fourth weeks (253.29±47.37 versus 443.22±42.72), body weight loss (13.22±5.70 versus 109.60±9.95) and lower cholesterol levels (58.75±3.13 versus 80.11±4.01) in control rats. Extract gavage at 200mg/Kg led to a decrease in glucose levels on the fourth week in diabetic rats, body weight loss in the second, third and fourth weeks in control rats, and lower cholesterol levels in diabetic and control rats. Islet hyperplasia (p=0.005) and pancreatic duct dilation (p=0.047) were observed in diabetic and control rats. Conclusion: Plathymenia extract reduced blood glucose levels in diabetic rats, and body weight in control rats, and promoted pancreatic islet hyperplasia in diabetic and control rats.

RESUMO Objetivo: Avaliar o efeito anti-hiperglicêmico do extrato hidroalcoólico de Plathymenia reticulata, alterações no peso, lipídeos e efeito sobre o pâncreas. Métodos: O diabetes foi induzido pela administração de estreptozotocina 65mg/kg, em 75 ratos Wistar adultos machos, divididos em 8 grupos diferentes: ratos diabéticos e controle + água, ratos diabéticos e controle + 100mg/kg ou 200mg/kg de extrato, ratos diabéticos e controle + gliburida. O tratamento foi realizado por gavagem (oral) por 30 dias. Níveis de glicose e peso foram verificados semanalmente. Os animais foram sacrificados, e amostras de lipídeos e do pâncreas foram analisadas. A análise estatística incluiu ANOVA, post-hoc Tukey-Kramer, teste t de Student pareado e teste do χ2, com nível de significância de 5%. Resultados: O extrato 100mg/kg promoveu redução nos níveis de glicose sanguínea em ratos diabéticos na segunda, terceira (198,71±65,27 versus 428,00±15,25) e quarta semanas (253,29±47,37 versus 443,22±42,72), perda de peso (13,22±5,70 versus 109,60±9,95) e diminuição do colesterol (58,75±3,13 versus 80,11±4,01) em ratos controle. Com extrato de 200mg/kg, houve redução dos níveis de glicose na quarta semana, nos ratos diabéticos; de peso na segunda, terceira e quarta semanas, nos ratos controle; e de colesterol nos animais diabéticos e controle. Ocorreram hiperplasia de ilhotas (p=0,005) e dilatação dos ductos pancreáticos (p=0,047) em ratos diabéticos e controles. Conclusão: O extrato de Plathymenia reduziu os níveis de glicose em ratos diabéticos e de peso em ratos controle, além de ter promovido hiperplasia de ilhotas pancreáticas em diabéticos e controles.
Descritores: Extratos Vegetais/farmacologia
Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/farmacologia
Fabaceae
-Glicemia/análise
Peso Corporal/efeitos dos fármacos
Colesterol
Ratos Wistar
Estreptozocina
Folhas de Planta
Diabetes Mellitus Experimental/induzido quimicamente
Modelos Animais de Doenças
Hiperplasia/patologia
Fitoterapia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Torres, Orlando Jorge Martins
Moura, Roberto Soares de
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Id: biblio-949248
Autor: Torres, Orlando Jorge Martins; Santos, Orlando José dos; Moura, Roberto Soares de; Serra, Humberto Oliveira; Ramos, Vanisse Portela; Melo, Syomara Pereira da Costa; Loureiro, Carlos Manoel Bulcão.
Título: Activity of orbignya phalerata and euterpe edules in the prevention and treatment of peptic ulcer in rats / Atividade de orbignya phalerata e euterpe edules na prevenção e tratamento da úlcera péptica em ratos
Fonte: ABCD arq. bras. cir. dig;31(3):e1390, 2018. tab.
Idioma: en.
Resumo: ABSTRACT Background: Peptic ulcer is considered a public health problem associated with loss of quality of life. Does not exist optimal therapeutic regimen. The search for alternative treatments using foods or plants that may assist in gastric protection may become marked in this population because of their easy access and low cost. Aim: To study the antiulcerogenic activity of extracts of Orbignya phalerata (babaçu) and Euterpe edules (juçara) in Wistar rats after induction of peptic ulcer, compared with Omeprazole. Method: Forty Wistar rats were distributed into four groups: group I, II, III, IV (10 rats each) subjected to extract of Orbignya phalerata, Euterpe edules, Omeprazole and ethanol, respectively. Each group of 10 rats was divided into subgroups of five for prophylaxis and therapeutic study. Results: The pre-treatment with juçara extract has provided a significant protection against peptic ulcer induced by ethanol. In the prophylactic subgroup, Omeprazole resulted in protection. In addition to protection against peptic ulcer, inflammation and neocapillarization were also variables with a statistical significance in the prophylaxis subgroups using omeprazole and juçara. In the therapeutic subgroup, omeprazole, juçara and babaçu were statistically different as for protection against the presence of inflammation and the healing of ulcers. Conclusion: The extracts of juçara and babaçu behaved as the omeprazole, evidencing the therapeutic activity of these extracts.

RESUMO Racional: A úlcera péptica é considerada problema de saúde pública, associada a perda na qualidade de vida. Não existe esquema terapêutico ideal. A busca de tratamentos alternativos, com uso de alimentos ou plantas que possam ajudar na proteção gástrica, torna-se viável à população, por ser de fácil acesso e baixo custo. Objetivo: Estudar a atividade antiulcerogênica dos extratos de Orbignya phalerata (babaçu) e Euterpe edules (juçara) em ratos Wistar após indução de úlcera péptica e comparar com omeprazol. Método: Quarenta ratos Wistar foram distribuídos em quatro grupos: grupo I, II, III, IV (10 ratos) submetidos ao extrato de Orbignya phalerata, Euterpe edules, omeprazol e álcool etílico, respectivamente. Cada grupo de 10 ratos foi dividido em subgrupos de cinco para estudar a profilaxia e tratamento. Resultados: O pré-tratamento com extrato de juçara forneceu proteção significativa contra a ulceração péptica induzida pelo etanol, assim como o omeprazol. Além da proteção contra úlcera péptica, inflamação e neocaplilarização também foram variáveis com significância estatística nos subgrupos profilaxia do omeprazol e da juçara. No subgrupo terapêutico, o omeprazol, juçara e babaçu teve diferença estatística para proteção contra a presença de inflamação e cicatrização de úlcera. Conclusão: Os extratos de juçara e babaçu se comportaram como omeprazol, evidenciando o poder terapêutico desses extratos.
Descritores: Úlcera Péptica/prevenção & controle
Extratos Vegetais/uso terapêutico
Arecaceae
Fitoterapia
-Ratos Wistar
Euterpe
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1290640
Autor: Córdova-Guerrero, Iván; Aragon-Martínez, Othoniel H; Díaz-Rubio, Laura; Franco-Cabrera, Santiago; Serafín-Higuera, Nicolas A; Pozos-Guillén, Amaury; Soto-Castro, Tely A; Martínez-Morales, Flavio; Isiordia-Espinoza, Mario.
Título: Actividad antibacteriana y antifúngica de un extracto de Salvia apiana frente a microorganismos de importancia clínica / Antibacterial and antifungal activity of Salvia apiana against clinically important microorganisms
Fonte: Rev. argent. microbiol;48(3):217-221, set. 2016. graf..
Idioma: es.
Resumo: Debido a la gran problemática mundial de la resistencia bacteriana a los antibióticos, es necesaria la búsqueda continua de nuevas moléculas con características antimicrobianas. Este estudio evaluó el efecto antibacteriano y antifúngico de un extracto hexánico proveniente de la raíz de Salvia apiana. Los extractos de salvia a las concentraciones de 27; 13,5; 6,8 y 3,4mg/ml causaron inhibición del crecimiento de Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis y Candida albicans. Sin embargo, no presentaron efecto significativo sobre Escherichia coli y Candida tropicalis al compararse con los valores del vehículo en las valoraciones de difusión en pozo. Se demostró que S. apiana tiene un efecto antimicrobiano significativo sobre patógenos de gran importancia clínica, lo que abre el campo para continuar evaluando a esta lamiácea en vistas a su posible empleo en el futuro como un agente terapéutico

Due to the great global concern regarding bacterial resistance to antibiotics, an ongoing search for new molecules having antibacterial activity is necessary. This study evaluated the antibacterial and anticandidal effects of a hexane extract from the root of Salvia apiana. Salvia extracts at concentrations of 27, 13.5, 6.8 and 3.4mg/ml caused growth inhibition of Staphylococcus aureus, Streptococcus pyogenes, Enterococcus faecalis and Candida albicans. However, no significant effect was observed on Escherichia coli and Candida tropicalis in comparison to vehicle. It was here demonstrated for the first time that Salvia apiana has an important antimicrobial effect on human pathogens of great clinical value, thus opening the field to continue the evaluation of this lamiaceous plant for its future use as a therapeutic agent
Descritores: Extratos Vegetais/análise
Extratos Vegetais/uso terapêutico
Produtos com Ação Antimicrobiana
Descoberta de Drogas
Antibacterianos/análise
Antifúngicos/análise
-Staphylococcus aureus/efeitos dos fármacos
Streptococcus pyogenes/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Enterococcus faecalis/efeitos dos fármacos
Tipo de Publ: Ensaio Clínico
Estudo de Avaliação
Responsável: AR635.1 - FCVyS - Servicio de Información y Documentación


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Id: biblio-1283173
Autor: Santana, Paula Andrea; Jara-Gutiérrez, Carlos; Mellado, Marco; Forero, Juan Carlos; Guzmán, Fanny; Barriga, Andrés; Albericio, Fernando; Álvarez, Claudio Andrés.
Título: Effects of elderflower extract enriched with polyphenols on antioxidant defense of salmon leukocytes
Fonte: Electron. j. biotechnol;52:13-20, July. 2021. tab, graf, ilus.
Idioma: en.
Resumo: BACKGROUND: In fish farming, the plant extracts containing antioxidant compounds have been added to the diet for enhancing pathogen resistance. In vitro studies evaluating the antioxidant effect of herbal extracts on fish cell models have focused on ROS production and the respiratory burst mechanism. However, the effects on enzymatic antioxidant defense on salmon leukocytes have not been evaluated. This study aims to evaluate the enzymatic antioxidant defense and ROS-induced cell damage in Salmon Head Kidney-1 (SHK-1) cell line exposed to polyphenol-enriched extract from Sambucus nigra flowers. RESULTS: Firstly, the Total Reactive Antioxidant Power (TRAP) assay of elderflower polyphenol (EP) was evaluated, showing 459 and 489 times more active than gallic acid and butyl hydroxy toluene (BHT), respectively. The toxic effect of EP on salmon cells was not significant at concentrations below 120 mg/ mL and no hemolysis activity was observed between 20 and 400 mg/mL. The treatment of SHK-1 cell line with EP decreased both the lipid peroxidation and protein oxidation induced by H2O2, which could be associated with decreasing oxidative stress in the SHK-1 cells since the GSH/GSSG ratio increased when only EP was added. CONCLUSIONS: These results suggest that plant extracts enriched with polyphenols could improve the enzymatic antioxidant defense of salmon leukocytes and protect the cells against ROS-induced cell damage
Descritores: Salmão
Extratos Vegetais/farmacologia
Sambucus nigra/química
Polifenóis/farmacologia
-Peroxidação de Lipídeos
Sequestradores de Radicais Livres
Espécies Reativas de Oxigênio
Aquicultura
Estresse Oxidativo
Salmo salar
Resistência à Doença
Leucócitos
Antioxidantes
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1141905
Autor: Rós, Adriana de Souza; Santos, Carlos Henrique Marques dos; Dourado, Doroty Mesquita; Silva-Neto, Moisés Soares da; Caldeira, Isabela; Furtado, Leandro de Oliveira.
Título: Can stryphnodendron adstringens extract improve the results of fistulotomy followed by primary sphincteroplasty in the treatment of transsphincteric fistulae? / Extrato de stryphnodendron adstringens pode melhorar os resultados da fistulotomia seguida por esfincteroplastia primária no tratamento de fístulas transesfincterianas?
Fonte: ABCD arq. bras. cir. dig;33(3):e1540, 2020. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background: There is still a need for progress in the treatment of transsphincteric anal fistulae and the use of herbal medicines seems promising. Aim: To evaluate the efficacy of Stryphnodendron adstringens associated with fistulotomy and primary sphincteroplasty in the treatment of transsphincteric fistulae in rats. Methods: Thirty Wistar rats were used, which were submitted to transsphincteric fistulas with steel wire 0; after 30 days a treatment was performed according to the group. Group A (n=10) was submitted to fistulotomy; group B (n=10), fistulotomy followed by primary sphincteroplasty with "U" stitch with polyglactin 911 4-0; group C(n=10) , similar to group B, but with the interposition between the muscular stumps of hemostatic sponge soaked in Stryphnodendron adstringens extract. Euthanasia was performed after 14 days, resecting a segment of the anal canal for histological analysis, which aimed to evaluate the closure of the fistula, the area of separation of the muscle cables, the inflammatory process and the degree of fibrosis. Results: No animal had a remaining fistulous tract. About the spacing between the muscle cables, an average of 106.3 µm2 was observed in group A, 82.8 µm2 in group B and 51.8 µm2 in group C (p<0.05). There was no difference between the groups regarding the inflammatory process and, in relation to fibrosis, in group A there was a mean of 0.6, in group B 0.7 and in group C 0.2 (p<0.05). Conclusions: Stryphnodendron adstringens extract was able to allow less spacing between muscle cables in rats submitted to fistulotomy followed by primary sphincteroplasty, in addition to providing less local fibrosis.

RESUMO Racional: Há ainda necessidade de avanço no tratamento das fístulas transesfincterianas e o uso de fitoterápicos parece promissor. Objetivo: Avaliar a eficácia da Stryphnodendron adstringens associada à fistulotomia e esfincteroplastia primária no tratamento de fístulas transesfincterianas em ratos. Métodos: Utilizou-se 30 ratos Wistar submetidos à confecção de fístulas transesfincterianas com fio de aço 0; após 30 dias realizou-se tratamento de acordo com o grupo. O grupo A (n=10) foi submetido à fistulotomia; o grupo B (n=10) fistulotomia seguida de esfincteroplastia primária com ponto em "U" com poliglactina 911 4-0; o grupo C (n=10), semelhante ao grupo B, porém com a interposição entre os cotos musculares de esponja hemostática embebida em extrato de Stryphnodendron adstringens. Realizou-se eutanásia após 14 dias, ressecando-se segmento do canal anal para análise histológica, que objetivou avaliar o fechamento da fístula, a área de afastamento dos cabos musculares, o processo inflamatório e o grau de fibrose. Resultados: Nenhum animal apresentou trajeto fistuloso remanescente. Quanto ao afastamento entre os cabos musculares observou-se média 106,3 µm2 no grupo A, 82,8 µm2 no grupo B e 51,8 µm2 no grupo C (p<0,05). Não houve diferença entre os grupos quanto ao processo inflamatório e, em relação à fibrose; no grupo A observou-se média 0,6, no grupo B 0,7 e no grupo C 0,2 (p<0,05). Conclusões: O extrato de Stryphnodendron adstringens foi capaz de permitir menor afastamento entre os cabos musculares em ratos submetidos à fistulotomia seguida por esfincteroplastia primária, além de proporcionar menor fibrose local.
Descritores: Procedimentos Cirúrgicos do Sistema Digestório
Extratos Vegetais/uso terapêutico
Fístula Retal/cirurgia
Fabaceae/química
-Canal Anal/cirurgia
Resultado do Tratamento
Ratos Wistar
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1253101
Autor: Tsai, Wen-Che; Chang, Hung-Chi; Yin, Hsin-Yi; Huang, Meng-Chieh; Chandra Agrawal, Dinesh; Wen, Hsiao-Wei.
Título: The protective ability and cellular mechanism of Koelreuteria henryi Dummer flower extract against hydrogen peroxide-induced cellular oxidative damage
Fonte: Electron. j. biotechnol;47:89-99, sept. 2020. ilus, tab, graf.
Idioma: en.
Resumo: BACKGROUND: Koelreuteria henryi Dummer is an indigenous plant in Taiwan. The species has been used in traditional folk medicine for the promotion of liver functions and for treating malaria and urethritis. The present study investigated the antioxidant activity of the flower extract of Koelreuteria henryi Dummer. The extraction conditions were optimized by the contents of total phenolic acids and total flavonoids, and antioxidant activity assays. Moreover, an in vitro study for investigating antioxidant activity of K. henryi flower extract was demonstrated by hydrogen peroxide (H2O2)-induced apoptosis. RESULTS: K. henryi flower extracted for 150 min showed high contents of total phenolic acids and total flavonoids. In an in vitro model, L929 cells were pretreated with K. henryi flower extract, and then treated with H2O2 to induce oxidative damage. Results demonstrated that H2O2-induced apoptosis was inhibited by the treatment of 200 µg/ml K. henryi flower extract through the mitochondria-mediated pathway and mitogen-activated protein kinase (MAPK) pathway. The caspase 8/9 activity and expression of p-p38 and pERK were repressed by K. henryi flower extract. In addition, the prevention of H2O2-induced apoptosis by K. henryi flower extract activated the nuclear factor-erythroid 2-related factor (Nrf2) stress response pathway to transcript heme oxygenase 1 (HO-1). Also, K. henryi flower extract prevented H2O2-induced apoptosis through HO-1 production, as evident by the use of HO-1 inhibitor. CONCLUSIONS: The present study demonstrated that K. henryi flower extract could inhibit the H2O2-induced apoptosis in L929 cells through the activation of the Nrf2/HO-1 pathway.
Descritores: Extratos Vegetais/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Sapindaceae/química
Antioxidantes/farmacologia
-Flavonoides/análise
Western Blotting
Apoptose
Flores/química
Heme Oxigenase-1
Fator 2 Relacionado a NF-E2
Caspase 8
Peróxido de Hidrogênio
Responsável: CL1.1 - Biblioteca Central



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