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Id: biblio-975977
Autor: Sepehrimanesh, Masood; Samimi, Nastaran; Koohi-Hosseinabadi, Omid; Mokhtari, Maral; Amiri-Zadeh, Saeed; Farjam, Mojtaba.
Título: Effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat / Efeitos do extrato de Cupressus sempervirens na cicatrização de colite ulcerativa induzida por ácido acético em ratos
Fonte: J. coloproctol. (Rio J., Impr.);38(4):309-313, Oct.-Dec. 2018. tab, graf.
Idioma: en.
Projeto: Fasa University of Medical Sciences.
Resumo: ABSTRACT Ulcerative colitis is a chronic inflammatory condition of the colon with an unknown etiology. In this study, we aimed to evaluate the therapeutic effects of Cupressus sempervirens extract on the healing of acetic acid-induced ulcerative colitis in rat. Fifty-five male rats divided into five equal treatment groups were used for this study and received the following treatments: Group 1, 250 mg/kg asacol; Group 2, 1 ml gel base (carboxymethyl cellulose); Group 3, 0.5% gel form of C. sempervirens extract; Group 4, 1% gel form of C. sempervirens extract, and; Group 5, considered as negative control and received 1 ml of normal saline. Body weight changes, histopathological and antioxidant changes in the colon tissue were evaluated. Significant weight gain was observed in rats that received 1% gel extract of C. sempervirens. Significant superoxide dismutase activity was also detected in 0.5 and 1% gel extract groups compared to C. sempervirens extract, Asacol and in 1% gel extract groups compared to the gel base group. Furthermore, both gel extract groups had significant lower total antioxidant capacity compared to Asacol group. Several histopathological lesions including inflammation, ulceration, crypt disarray, and goblet cell depletion were detected in the different groups, however, the mean rank of pathological changes showed no significant difference among the five groups. In summary, our results showed that hydroalcoholic extracts of C. sempervirens leaves produces healing effects in acetic acid induced ulcerative colitis.

RESUMO A colite ulcerativa é uma doença inflamatória crônica do cólon com uma etiologia desconhecida. O objetivo deste estudo foi avaliar os efeitos terapêuticos do extrato de Cupressus sempervirens na cicatrização de colite ulcerativa induzida por ácido acético em ratos. Cinquenta e cinco ratos machos divididos em cinco grupos de tratamento iguais foram utilizados para este estudo e receberam os seguintes tratamentos: Grupo 1: 250 mg/kg de asacol; Grupo 2: 1 mL de gel base (carboximetilcelulose); Grupo 3: extrato de C. sempervirens a 0,5% em gel; Grupo 4: extrato de C. sempervirens a 1% em gel e; Grupo 5: considerado controle negativo que recebeu 1 mL de solução salina normal. Alterações no peso corporal, alterações histopatológicas e antioxidantes no tecido do cólon foram avaliadas. Ganho de peso significativo foi observado em ratos que receberam extrato em gel de C. sempervirens a 1%. Atividade significativa de superóxido dismutase também foi detectada em grupos de extrato em gel de 0,5 e 1% em comparação com o extrato de C. sempervirens, Asacol e em grupos de extrato em gel a 1% em comparação com o grupo base de gel. Além disso, ambos os grupos de extrato em gel apresentaram capacidade antioxidante total significativamente menor em comparação ao grupo Asacol. Várias lesões histopatológicas, incluindo inflamação, ulceração, desarranjo da cripta e depleção de células caliciformes foram detectadas nos diferentes grupos; no entanto, a classificação média de alterações patológicas não apresentou diferença significativa entre os cinco grupos. Em resumo, nossos resultados mostraram que extratos hidroalcoólicos de folhas de C. sempervirens produzem efeitos cicatrizantes em colite ulcerativa induzida por ácido acético.
Descritores: Colite Ulcerativa
Cupressus australis/uso terapêutico
Colo/patologia
Antioxidantes
-Cicatrização/efeitos dos fármacos
Extratos Vegetais
Limites: Animais
Ratos
Responsável: BR545.3 - Biblioteca ICBS


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Id: biblio-951809
Autor: Paz, Jorge Enrique Wong; Contreras, Carolina Rubio; Munguía, Abigail Reyes; Aguilar, Cristóbal Noé; Inungaray, María Luisa Carrillo.
Título: Phenolic content and antibacterial activity of extracts of Hamelia patens obtained by different extraction methods
Fonte: Braz. j. microbiol;49(3):656-661, July-Sept. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Hamelia patens, is a plant traditionally used to treat a variety of conditions among the Huastec people of Mexico. The objective of this study is to characterize the phenolic content and critically examine the antimicrobial activity of leaf extracts H. patens, obtained by maceration, Soxhlet and percolation, using ethanol as 70% solvent. Phenolic compounds are characterized by liquid chromatography, coupled to a High Resolution Mass Spectrometry, and the antimicrobial activity was studied from the inhibitory effect of each extract for Escherichia coli, Staphylococcus aureus, Salmonella typhi and S. paratyphi, and by the Minimum Bactericidal Concentration, the percentage of activity and the Index of Bacterial Susceptibility of each extract. The phenolic compound identified in different concentrations in the three extracts was epicatechin. The extracts obtained by the three methods had antimicrobial activity, however, there was no significant difference (p < 0.05) between the Minimum Bactericidal Concentration of the extracts obtained by maceration, percolation and Soxhlet. The results of this study contribute to the body of knowledge on the use of extracts in controlling microorganisms with natural antimicrobials.
Descritores: Fenóis/isolamento & purificação
Fenóis/farmacocinética
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacocinética
Hamelia/química
Fracionamento Químico/métodos
Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
-Fenóis/química
Staphylococcus aureus/efeitos dos fármacos
Extratos Vegetais/química
Testes de Sensibilidade Microbiana
Escherichia coli/efeitos dos fármacos
México
Antibacterianos/química
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-974327
Autor: Souza, Juliana Leitzke Santos de; Guimarães, Victoria Burmann da Silva; Campos, Angela Diniz; Lund, Rafael Guerra.
Título: Antimicrobial potential of pyroligneous extracts - a systematic review and technological prospecting
Fonte: Braz. j. microbiol;49(supl.1):128-139, 2018. tab, graf.
Idioma: en.
Projeto: CAPES; . FAPERGS.
Resumo: Abstract Pyroligneous extract is applied in diverse areas as an antioxidant, an antimicrobial, and an anti-inflammatory agent. The discovery of new cost-effective antimicrobial agents of natural origin remains a challenge for the scientific community. This study aimed to conduct a systematic review and a technological forecasting of the existent evidence regarding the use of pyroligneous extract as a potential antimicrobial agent. Studies were identified through an investigation of various electronic databases: PubMed, SciFinder, Web of Science, Scopus, Scielo, Google scholar, and ProQuest. Patents were searched through INPI, Google patents, Espacenet, Patents online, USPTO, and WIPO. The literature on antimicrobial activity of pyroligneous extract are limited given the short duration of studies and variability in study design, use of pyroligneous preparations, and reports on results. However, evidence suggests the potential of pyroligneous extract as a natural antimicrobial agent. The most studied activity was the role of PE as a food preservative. However, pyroligneous extracts are also effective against pathogenic bacteria in the oral microflora and treatment of candidal infections. Further research is needed using standardized preparations of pyroligneous extracts to determine their long-term effectiveness and ability as antimicrobial agents.
Descritores: Madeira/química
Extratos Vegetais/farmacologia
Conservantes de Alimentos/farmacologia
Anti-Infecciosos/farmacologia
-Bactérias/efeitos dos fármacos
Extratos Vegetais/química
Conservantes de Alimentos/química
Fungos/efeitos dos fármacos
Anti-Infecciosos/química
Limites: Seres Humanos
Animais
Responsável: BR1.1 - BIREME


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Id: biblio-1039032
Autor: Ahmed, Muhammad; Azmat, Aisha; Khan, Salahuddin.
Título: Acute hypotensive and diuretic activities of Berberis vulgaris root bark aqueous extract in normal rats
Fonte: Braz. J. Pharm. Sci. (Online);53(4):e17077, 2017. tab, graf.
Idioma: en.
Resumo: The aim of this study is to investigate the effectiveness of intravenous administration of Berberis vulgaris root bark aqueous extract (BRBD) on the cardiovascular and renal functions of healthy normotensive rats. The different doses of BRBD 1, 10 and 20 mg/kg were administered intravenously (i.v) in normal rats. Blood pressure, diuretic activity and serum renal profile were analyzed. Intravenous injection of BRBD at the different doses of 1, 10 and 20 mg/kg showed a dose-dependent reduction in mean arterial blood pressure (P<0.001). At different doses of 1, 10 and 20 mg/kg, the hypotensive effect remained for more than one hour. Single dose administration of BRBD at doses of 10 and 20 mg/kg caused a significant increase in urine output (P<0.001) as compared to the control rats. Serum renal profile test (albumin, Urea, Uric Acid, creatinine and BUN) did not show any significant alteration. The authors conclude that the BRBD is a potent hypotensive and possesses diuretic potential
Descritores: Extratos Vegetais/efeitos adversos
Berberis vulgaris/efeitos adversos
Administração Intravenosa/instrumentação
-Casca de Planta
Pressão Arterial/efeitos dos fármacos
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1039037
Autor: Erhirhie, Earnest Oghenesuvwe; Ilodigwe, Emmanuel Emeka.
Título: Sub-chronic toxicity evaluation of Dryopteris filix-mas (L. ) schott, leaf extract in albino rats
Fonte: Braz. J. Pharm. Sci. (Online);55:e18107, 2019. tab, graf.
Idioma: en.
Resumo: This study evaluated the acute and sub-chronic toxicities of ethanol leaf extract of Dryopteris filix-mas. Acute toxicity and phytochemical tests on ethanol leaf extract were determined. In sub-chronic toxicity test, animals were treated with 62.5, 125, 250 and 500 mg/kg of extract every day for 90 days. Blood samples were collected via retro-orbital puncture for baseline studies and at 31, 61 and 91st days for determination of hematological, kidney and liver function parameters. Liver and kidneys were harvested for histopathology analyses on 91st day. Also, a 28 day recovery study was carried out to determine reversibility in toxicological effects. Phytochemical screening revealed the presence of tannins, phenols, flavonoids, saponins, steroids, alkaloids, terpenoids, reducing sugar and cardiac glycosides. Acute toxicity test did not show toxicity or death at 5000 mg/kg. There was significant (p<0.005) reduction in white blood cell and lymphocyte counts, significant (p<0.05) increase in some liver and kidney biomarkers as well as alterations in liver and kidney histo-architecture on 91st days in animals that were treated with 250 and 500 mg/kg extract. However, toxicities observed on 91st day were reversible in recovery studies. The leaf extract of Dryopteris filix-mas may be hepatotoxic and nephrotoxic when used for long periods
Descritores: Extratos Vegetais/análise
Toxicidade Aguda/efeitos adversos
Dryopteris/toxicidade
Testes de Toxicidade Subcrônica/instrumentação
-Etanol/toxicidade
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1039042
Autor: Rabiei, Zahra; Setorki, Mahbubeh.
Título: Effect of ethanol Adiantum capillus-veneris extract in experimental models of anxiety and depression
Fonte: Braz. J. Pharm. Sci. (Online);55:e18099, 2019. tab, graf.
Idioma: en.
Resumo: Depression is one of the most common psychiatric disorders with a prevalence of 15%-25%. Monoamine aminotransferases, in particular, norepinephrine, serotonin, and dopamine, change in the brain of depressed people. Adiantum capillus-veneris is one of the species of the maidenhair fern genus that have traditionally been used to treat cough, cold symptoms, and local hair loss.In this experimental study, white male rats weighing 250-300 g were assigned to 5 groups of 10 each; group 1: Receiving normal saline; groups 2-4: Receiving A.capillus-veneris extract at 50, 100, and 200 mg/kg, respectively; and group 5: Receiving fluoxetine at 10 mg/kg. Chronic unpredictable stress (CUS) was induced by 3-week exposure to chronic stress. The forced swim test and plus maze were used to assess depression and anxiety, respectively. Malondialdehyde (MDA) levels and antioxidant capacity in the serum and brain were measured. Treatment with A.capillus-veneris extract at 200 mg/kg significantly reduced the duration of immobility. In the group given extract at 200 mg/kg, a significant increase in the number of open arm entries was observed when compared to the control group. A.capillus-veneris extract at 50, 100, and 200 mg/kg resulted in a significant increase in the time spent in the open arm. A.capillus-veneris extract reduced MDA levels and increased antioxidant levels of serum and brain in rat. A.capillus-veneris has significant antidepressant and anti-anxiety effects in rat, probably due to its antioxidant and anti-inflammatory activities.
Descritores: Ansiedade/diagnóstico
Extratos Vegetais/efeitos adversos
Adiantum/classificação
Depressão/diagnóstico
-Estresse Oxidativo/fisiologia
Antioxidantes/administração & dosagem
Limites: Animais
Masculino
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-907045
Autor: Bonilla Rivera, Pablo Enrique; Fernández Rebaza, Gustavo Adolfo; Bustamante Peñaloza, Luis Enrique; Casas Martel, Luby Evelyn; Cirineo Rodríguez, Mishell Xiomi; Hinostroza Lorenzo, Mónica Lucero; Villar Melendez, Heidy Cristina; Yupanqui Gallegos, Briggitte Marylin.
Título: Determinacion estructural de flavonoides en el extracto etanolico de cladodios de Opuntia ficus-indica (L.) Mill. "Tuna Verde" / Structural identification of flavonoids in ethanolic extract of Opuntia ficus-indica (L.) Mill. "Tuna Verde" cladodes
Fonte: Rev. peru. med. integr;2(4):835-840, 2017. ilus, tab, graf.
Idioma: es.
Resumo: Objetivos: Determinar estructuralmente los flavonoides encontrados en el extracto etanólico de cladodios de Opuntia ficus-indica (L.) Mill. "Tuna Verde". Materiales y métodos: Se preparó el extracto etanólico de cladodios de Opuntia ficus-indica (L.) Mill. Luego se detectaron sus componentes mediante un tamizaje fitoquímico. A través de cromatografía en capa fina se aislaron los compuestos fenólicos tipo flavonoides. Finalmente, usando espectroscopia UV/Vis se propuso la posible estructura de los flavonoides encontrados. Resultados: El tamizaje fitoquímico mostró presencia de compuestos fenólicos, flavonoides y glicósidos. Se propuso cinco estructuras químicas de compuestos fenólicos, todas con un núcleo en común: flavona, mediante las lecturas en el espectrofotómetro UV/Vis y por comparación con lo publicado por TJ Mabry. Conclusión: Se determinó la posible estructura química de cinco flavonoides presentes en el extracto etanólico de cladodios de Opuntia ficus-indica (L.) Mill. "Tuna Verde".
Descritores: Flavonoides
Extratos Vegetais/uso terapêutico
Opuntia/química
Compostos Fitoquímicos
-Peru
Análise Espectral
Cromatografia
Limites: Seres Humanos
Tipo de Publ: Técnicas In Vitro
Responsável: BR1.1 - BIREME


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Id: biblio-907030
Autor: Gamarra, Vidal; Fuertes, César; Chávez, Nadia; Contreras, Dennis; Goya, Eri; Huamantumba, Kelly; Retuerto, Fernando; Ruiz Pacco, Gustavo.
Título: Metabolitos en las hojas de Erythroxylum coca Lam y Erithroxylum novogranatense (Morris) Hieron y evaluacón de sus propiedades biológicas mediante bioensayos / Metabolites detected in Erythroxylum coca Lam y Erythroxylum novogranatense (Morris) Hieron leaves and evaluation of their biological activities by bioessay
Fonte: Rev. peru. med. integr;2(4):828-834, 2017. tab, graf.
Idioma: es.
Resumo: Objetivo: Realizar el screening fitoquímico y determinar la actividad antioxidante y antibacteriana de los flavonoides y alcaloides aislados de extractos etanólicos de las hojas de Erythroxylum coca Lam y Erythroxylum novogranatense (Morris) Hieron. Materiales y Métodos: La capacidad antioxidante de los flavonoides y alcaloides aislados fue evaluada mediante el ensayo de DPPH, utilizando como control positivo a la vitamina C, y la actividad antibacteriana mediante el cálculo del halo de inhibición (mm) ante S. epidermidis, P. aeruginosa, S. aureus y E. coli. Resultados: Los alcaloides de E. coca presentaron mayor actividad antibacteriana frente a S. epidermidis y P. aeruginosa, y los flavonoides de E. novogranatense tuvieron mayor actividad frente a S. epidermidis, P. aeruginosa y S. aureus. E. novogranatense mostroun EC50 de 271,20 µg/mL para extracto crudo y 250,29 µg/mL para flavonoides, mientras que E. coca presento un EC50 de 172,59 µg/mL para extracto crudo y 611,29 µg/mL para flavonoides. Conclusión: En ambas especies se identificaron alcaloides (cocaína y benzoilecgonina), flavonoides (chalconas y flavonoles), fenoles y carbohidratos. Los flavonoides de Erythroxylum novogranatense (Morris) Hieron, y el extracto de Erythroxylum coca Lam presentaron mayor actividad antioxidante. El extracto de Erythroxylum coca Lam mostro mayor actividad antibacteriana frente a S. aureus, S. epidermidis y E. coli, excepto para P. aeruginosa. Los alcaloides de Erythroxylum coca Lam, exhibieron buena actividad frente a S. epidermidis y P. aeruginosa; excepto para E. coli, donde Erythroxylum novogranatense (Morris) Hieron tuvo mejor desempeño. Los flavonoides aislados de Erythroxylum novogranatense (Morris) Hieron mostraron actividad frente a S. epidermidis.
Descritores: Flavonoides
Coca
Alcaloides
Compostos Fitoquímicos
Antibacterianos
Antioxidantes
-Peru
Bioensaio
Extratos Vegetais
Programas de Rastreamento
Limites: Seres Humanos
Tipo de Publ: Técnicas In Vitro
Responsável: BR1.1 - BIREME


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Id: biblio-906542
Autor: Mayhuasca Ysuhuaylas, Olinda; Arroyo Acevedo, Jorge; Franco Quino, César.
Título: Efecto antiinflamatorio de la emulsión dérmica del extracto etanólico de Peperomia choroniana D. CD. (ipitanki) en edema auricular inducido por xilol en ratones / Anti-inflammatory effect of a dermal emulsion obtained from an ethanolic extract of Peperomia choroniana D. CD. (Ipitanki) on xylene-induced edema in mice
Fonte: Rev. peru. med. integr;2(4):817-822, 2017. ilus, tab.
Idioma: es.
Resumo: Objetivo: Evaluar el efecto antiinflamatorio de la emulsión dérmica del extracto etanólico de Peperomia choroniana en edema auricular inducido por xilol en ratones. Materiales y Métodos: Estudio Experimental. Se elaboró una emulsión dérmica del extracto etanólico de partes aéreas de Peperomia choroniana, la que se aplicó en ratones Swiss a quienes se les indujo inflamación con Xilol. Se formaron seis grupos de seis ratones cada uno. El grupo I recibió Crema Base; el grupo II, Dexametasona crema 0.05%; el grupo III, diclofenaco gel 1%; los grupos IV, V y VI; emulsión dérmica del extracto etanólico de Peperomia choroniana a las concentraciones de 0.1%, 0.5% y 1% respectivamente. Posterior a ello, se midió los indicadores de edema auricular de ratones (diferencia de peso), inflamación cualitativa, temperatura auricular y se realizo un estudio histopatológico. Resultados: Se encontró efecto antiinflamatorio en las emulsiones dérmicas de Peperomia choroniana al 0.5% (54.6%) y al 1% (51.1%); así­ mismo, la emulsión dérmica al 0.5% redujo significativamente (p<0.05) la temperatura auricular. El estudio histopatológico mostró escaso infiltrado inflamatorio e incremento de fibroblastos en los grupos tratados con la emulsión a diferentes concentraciones. Conclusiones: La emulsión dérmica de Peperomia choroniana al 0.5% posee efecto antiinflamatorio tópico superior al diclofenaco gel 1% pero inferior a la dexametasona crema 0.05% en la reducción de la inflamación y temperatura localizada.
Descritores: Extratos Vegetais/uso terapêutico
Peperomia
Anti-Inflamatórios
-Peru
Plantas Medicinais
Medicina Tradicional
Limites: Animais
Camundongos
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1039045
Autor: Nassima, Boumghar; Nassima, Behidj; Riadh, Ksouri.
Título: Antimicrobial and antibiofilm activities of phenolic compounds extracted from Populus nigra and Populus alba buds (Algeria)
Fonte: Braz. J. Pharm. Sci. (Online);55:e18114, 2019. tab, graf.
Idioma: en.
Resumo: The interest of this work is the discovery of new antimicrobial agents of plant origin to inhibit the formation of microbial biofilms. The present research was conducted to identify and quantify the phenolic compounds extracted from Populus nigra and Populus alba buds harvested in the area of Tizi-Ouzou (Algeria), and to evaluate their antimicrobial and antibiofilm activity. High performance liquid chromatography (HPLC) was performed to identify the phenolic compounds in the ethyl acetate fraction of P. nigra and the methanolic extracts of P. nigra and P. alba. The antimicrobial activity of the crude extracts and the fractions of these two species was tested against 11 microorganisms, using the disk diffusion method, while the antibiofilm effect of certain extracts was carried out in a 96-well microplate and on a biomaterial (catheter). HPLC analysis revealed the presence of 10 bioactive compounds. The main phenolic compounds identified in the three extracts were p-coumaric acid, ellagic acid, and Kaempferol. This study was able to demonstrate that the extracts of P. nigra and P. alba buds have interesting antimicrobial properties, with diameters ranging from 6.6 to 21.3 mm. In addition, extracts of P. nigra exhibited antibiofilm effects greater than 70%. Our results provide evidence for the antimicrobial and antibiofilm potential of bud extracts from both poplar species. Thus, these results will pave the way for further research on these two plants.
Descritores: Extratos Vegetais
Biofilmes/classificação
Populus/anatomia & histologia
Anti-Infecciosos/farmacocinética
-Cromatografia Líquida de Alta Pressão/instrumentação
Argélia/etnologia
Compostos Fenólicos/análise
Polifenóis/farmacocinética
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas



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