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Pesquisa : D20.215.784.500.350 [Categoria DeCS]
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Id: biblio-974328
Autor: Yang, Guodong; Li, Peng; Meng, Lifen; Xv, Keyi; Dong, Faming; Qiu, Yan; He, Lei; Lin, Lin.
Título: Diversity and communities of culturable endophytic fungi from different tree peonies (geoherbs and non-geoherbs), and their biosynthetic potential analysis
Fonte: Braz. j. microbiol;49(supl.1):47-58, 2018. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: Abstract To know more about the potential roles of endophytic fungi in the formation mechanism of Daodi medicinal material, diversity and communities of culturable endophytic fungi in three types of tree peonies were investigated. Endophytic fungi of three types of tree peonies were isolated and identified. The diversity was analyzed. Bayesian trees constructed by MrBayes 3.2.6 after phylogenetic analysis of the ITS sequences. The endophytic fungi potential for synthesis of natural products was assessed by means of detecting NRPS and PKS gene sequences. In total, 364 endophytic fungi isolates representing 26 genera were recovered from Paeonia ostii 'Feng Dan', Paeonia ostii 'Luoyang Feng Dan', and Paeonia suffruticosa 'Luoyang Hong'. More culturable endophytic fungi appeared in P. suffruticosa 'Luoyang Hong' (206) compared with P. ostii 'Feng Dan' (60) and P. ostii 'Luoyang Feng Dan' (98). The fungal community of P. ostii 'Feng Dan' had the highest richness and diversity. PKSs and NRPS detection rates of endophytic fungi from P. ostii 'Feng Dan' are both the highest among the three types of tree peonies. Results indicate that endophytic fungus is an important factor of Daodi Cortex Moutan forming, and endophytic fungi in peony are related to genuineness of Cortex Moutan.
Descritores: Produtos Biológicos/metabolismo
Paeonia/microbiologia
Biodiversidade
Endófitos/isolamento & purificação
Fungos/isolamento & purificação
-Filogenia
Medicamentos de Ervas Chinesas/metabolismo
Paeonia/classificação
Paeonia/crescimento & desenvolvimento
Paeonia/metabolismo
Endófitos/classificação
Endófitos/crescimento & desenvolvimento
Endófitos/genética
Fungos/classificação
Fungos/crescimento & desenvolvimento
Fungos/genética
Responsável: BR1.1 - BIREME


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Id: lil-792409
Autor: Zhang, Jing; Shen, Juan; Yin, Weiwei; Wei, Xiaoyu; Wu, Ligao; Liu, Hao.
Título: The intervention research on treatment by Xianchen to rabbits model of chemotherapeutic phlebitis
Fonte: Acta cir. bras;31(8):549-556, Aug. 2016. tab, graf.
Idioma: en.
Projeto: Natural Science Foundation of Anhui; . Innovation Plan of Bengbu Medical College.
Resumo: ABSTRACT PURPOSE: To develop a chemotherapeutics induced phlebitis and explore the effects of Xianchen on the phlebitis treatment. METHODS: Forty-eight rabbits were divided into two series. Phlebitis model induced by vincristine was established at each series. The first series had 24 rabbits, which were divided into four groups (6 hours, 12 hours, 18 hours, 24 hours) after vincristine infusion. The grades of phlebitis through visual observation and histopathological examination were observed. The second series had also 24 rabbits. Interventions were performed 12 hours after vincristine infusion. These rabbits were randomly divided into four groups, according to treatment: Hirudoid (bid), Xianchen (daily), Xianchen (tid), Xianchen (five times a day). Four days after intervention, the venous injury through visual observation and histopathological examination were evaluated. RESULTS: Series 1: Phlebitis appeared 12 hours after infusion of vincristine through visual observation. There was a significant difference (p<0.05) between 6 hours and 24 hours, 6 hours and 18 hours through visual observation. However, the inflammation happened 6 hours after infusion, the loss of venous endothelial cells demonstrated differences among four groups through histopathological evaluation (p<0.05). There were significant differences (p<0.05) after 4 days among the intervention groups through visual observation, the effects of Xianchen group (five times a day) were better than Xianchen group (tid) (p<0.01). The treatment of edema demonstrated differences among groups through histopathological evaluation (p<0.05), Xianchen (five times a day) better relieved the degree of edema (p<0.05). CONCLUSIONS: The study showed that inflammatory reaction of phlebitis appeared early. Xianchen can treat vincristine induced phlebitis, as well as Hirudoid. It is particularly effective in the treatment of edema, and there is a remarkable dose-response relationship.
Descritores: Flebite/tratamento farmacológico
Medicamentos de Ervas Chinesas/administração & dosagem
Extratos Vegetais/administração & dosagem
Edema/tratamento farmacológico
Fitoterapia/métodos
Anti-Inflamatórios/administração & dosagem
-Flebite/induzido quimicamente
Flebite/prevenção & controle
Vincristina
Infusões Intravenosas
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Medicina Tradicional Chinesa/métodos
Limites: Animais
Coelhos
Responsável: BR1.1 - BIREME


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Id: lil-731217
Autor: Novaretti, Marcia Cristina Zago; Santos, Edzangela de Vasconcelos; Quitério, Ligia Maria; Daud-Gallotti, Renata Mahfuz.
Título: Sobrecarga de trabalho da Enfermagem e incidentes e eventos adversos em pacientes internados em UTI / Nursing workload and occurrence of incidents and adverse events in ICU patients / Sobrecarga de trabajo de Enfermería y los incidentes y eventos adversos en pacientes hospitalizados en la UCI
Fonte: Rev. bras. enferm;67(5):692-699, Sep-Oct/2014. tab.
Idioma: pt.
Projeto: Fapesp.
Resumo: Estudo prospectivo, tipo coorte que visou identificar a influência da sobrecarga de trabalho da Enfermagem na ocorrência de incidentes sem lesão e eventos adversos em 399 pacientes internados em Unidades de Terapia Intensiva (UTI). Para coleta de dados, foi aplicado um questionário estruturado e feita análise de prontuários. Nessas admissões, aproximadamente 78% dos incidentes sem lesão e eventos adversos em pacientes foram relacionados à esfera da Enfermagem. Essas ocorrências foram atribuídas à sobrecarga de trabalho, aumentaram o número de dias de internação e o risco de óbito dos pacientes estudados. É fundamental que os gerentes de enfermagem atuem no processo de gestão de pessoas no âmbito hospitalar, evitando a sobrecarga de trabalho e proporcionando, consequentemente, aumento da segurança do paciente.

This prospective cohort study aimed to identify the influence of nursing work overload on the occurrence of incidents without injury and adverse events in 399 patients hospitalized in Intensive Care Units (ICU). For data collection, a structured questionnaire was administered and an analysis of medical records was performed. In these admissions, approximately 78% of incidents without injury and adverse events in patients were related to the sphere of Nursing. These occurrences were attributed to overwork, increased the number of days of hospitalization and the risk of death of patients. It is essential that nursing managers work on the staff hospital management avoiding work overload to contribute for patient safety.

Estudio de cohorte prospectivo que tuvo como objetivo identificar la influencia de la carga de trabajo de enfermería en la ocurrencia de incidentes sin lesión y los eventos adversos en 399 pacientes ingresados en Unidades de Cuidados Intensivos (UCI). Para la recolección de datos, se administró un cuestionario estructurado y realizó el análisis de los registros en prontuarios. En estos ingresos, aproximadamente el 78% de los incidentes sin lesión y los eventos adversos en los pacientes estaban relacionados con el ámbito de la Enfermería. Estos hechos fueron atribuidos al exceso de trabajo, aumentaran el número de días de hospitalización y el riesgo de muerte de los pacientes. Es esencial que los responsables de enfermería que actúan en el proceso de gestión de las personas en los hospitales, eviten el exceso de trabajo y por lo tanto proporcionar una mayor seguridad de los pacientes.
Descritores: Medicamentos de Ervas Chinesas/farmacologia
Hepatócitos/efeitos dos fármacos
-Apoptose/efeitos dos fármacos
CASPASE ABATTOIRS
Caspases/metabolismo
Divisão Celular/efeitos dos fármacos
Linhagem Celular
Ativação Enzimática/efeitos dos fármacos
Hepatócitos/citologia
Cirrose Hepática/tratamento farmacológico
Fitoterapia
Salvia miltiorrhiza
Limites: Animais
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-623976
Autor: Zhou, Jun.
Título: Bioactive glycosides from Chinese medicines
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):231-234, 1991. ilus.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Glycosides are the bioactive components of many famous Chinese medicines. Here reported are some bioactive glycosides we discovered from Chinese medicines in recent years. (1) Pheolic glycosides from Chinese medicines: Gastrodia elata, acontium austroynanense and Helicia erratica, three bioactive phenolic glycosides were discovered and two of them have been developed into new drugs. (2) Terpenoidal glycosides: a) Monoterpenoid: the sweroside from Swertia mollensis has been developed intro an anti-hepatitis drug; b) Diterpenoid: Phlomis betonicoides contains sweet glycoides; c) Triterpenoid: many biologically active triterpenoid glycosides were isolated from Panax plants and Siraitia grosvenorii. (3) Steroidal glycosides: a) C21-steroid: Cynanchum otophyllum and C. atratrum contain anti-epilepsy and-tumor glycosides; b) C27-steroid Hemostatic saponins were found in Paris polyphylla.
Descritores: Saponinas/isolamento & purificação
Esteroides/isolamento & purificação
Esteroides/farmacologia
Edulcorantes/isolamento & purificação
Terpenos/isolamento & purificação
Terpenos/farmacologia
Medicamentos de Ervas Chinesas/química
Glicosídeos/uso terapêutico
Hepatite/tratamento farmacológico
Antineoplásicos Fitogênicos/isolamento & purificação
-Anticonvulsivantes/isolamento & purificação
Limites: Seres Humanos
Animais
Responsável: BR1.1 - BIREME


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Id: lil-623974
Autor: Zhou, Bing-Nan.
Título: Some progress on the chemistry of natural bioactive terpenoids form Chinese medicinal plants
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):219-226, 1991. ilus, graf.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: (1) Pseudolaric acids - Novel diterpenes, Pseudolaric acid A, B, C and D were isolated from Pseudolarix kaempferi Gorden (pinaceae). Their structures were assigned by spectroscopic data and chemical correlations. In the contineous studies, the absolute configurations, the conformations in the solutions, the framentation mechanisms of MS and assigments of all NMR spectral signals were also reported. They showed the antifungal and cytotoxic activities. (2) Daphnane diterpenes - In the further studies on the plants of Thymelaeaceae, besides 10 known diterpenes, 16 new daphnane diterpenes were isolated from Daphne genkwa, D. tangutica, D. giraldii, Wikstroemie chamaedaphne. They showed the antifertilities activities. (3) Tripterygium diterpenes 14 new diterpenes were isolated from Triperygium wilfordii, T. regeli and T. hypoglaucum. Some of them showed the antitumor activities. The CD spectra showed that A/B ring of all compoundshave trans configuration as same as tripdiolide and triptolide determined by X-ray diffraction (4) Pregnane glycosides from Marsdenia koi - Two new pregnane glycosides marsdenikoiside A and marsdenikoiside B which can terminate the early pregnancy were isolated from Marsdeia koi. Their structures were elucidated by hydrolysis and spectroscopic methods.
Descritores: Relação Estrutura-Atividade
Medicamentos de Ervas Chinesas/química
Anticoncepcionais/isolamento & purificação
Anticoncepcionais/uso terapêutico
Diterpenos/isolamento & purificação
/química
FRUITTEMEFOS/química
-Espectroscopia de Ressonância Magnética
Estrutura Molecular
Conformação Molecular
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-623964
Autor: Zhu, Xing-Zu.
Título: Development of natural products as drugs acting on central nervous system
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):173-175, 1991.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: We have recenty studied several natural product constituents which have effects on the CNS. (1) Tetrahydropalmatine (THP) and its analogues were isolated from Corydalis ambigua and various species of Stephania. (+)-THP and (-)-THP posses not only analgesic activity, but also exert sedative-tranquillizing and hypnotic actions. Results of receptor binding assay and their pre-and post-synaptic effects on dopaminergic system indicate that (-)-THP and (-)-stepholidine are dopamine receptor antagonists while (+)-THP is a selective dopamine depletor. (2) 3-Acetylaconitine (AAC) is an alkaloid isolated from Aconitum flavum. The relative potency of analgesic action of AAC was 5.1-35.6 and 1250-3912 times that of morphine and aspirin, respectively. The analgesic effect of AAC was antagonized by naloxone, but was eliminated by reserpine. In monkeys, after AAC was injected for 92 days, no abstinence syndrome was seen after sudden AAC withdrawal or when challenged with nalorphine. (3) Huperzine A (Hup-A) is an alkaloid isolated from Huperzia serrata which was found to be a selective ChE inhibitor and could improve learning and retrieval process. Preliminary clinical studies showed that Hup-A improve short-and long-term memory in patients of cerebral arteriosclerosis with memory impairment. (4) Ranamargarin is a new tetradecapeptide isolated from the skin of the Chines frog Rana margaratae. This peptide may mainly act on NK-1 receptor.
Descritores: Medicamentos de Ervas Chinesas/farmacologia
Depressores do Sistema Nervoso Central/farmacologia
Fármacos do Sistema Nervoso Central/farmacologia
Transtornos da Memória/tratamento farmacológico
-Dados de Sequência Molecular
Sequência de Aminoácidos
Avaliação de Medicamentos
Avaliação Pré-Clínica de Medicamentos
Limites: Seres Humanos
Animais
Responsável: BR1.1 - BIREME


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Id: lil-623962
Autor: Wang, Bin-Ji.
Título: The research on radioprotective agents in Chinese materia medica
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):165-167, 1991. tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: A series of studies has been carried out in the field of traditional medicine for searching radio-protective agents. According to the theory of traditional Chinese medicine, may prescriptions were tested with experimental animals. Some of them could raise the survival rate of dogs irradiated with lethal dose of Pi-rays by 30-40%. Some symptoms of radiation sickness could be improved. More than one thousand kinds of Chinese herbs were screened. Some of them have pronounced radioprotectice activities. A series of bioactive components wee isolated from these herbs. The mechanism of radiation protection were studied. Having the capability of hemopoietic system and immune system may be the characteristics of these Chinese herbs.
Descritores: Lesões Experimentais por Radiação/prevenção & controle
Protetores contra Radiação/isolamento & purificação
Protetores contra Radiação/farmacologia
-Medicamentos de Ervas Chinesas/farmacologia
Avaliação de Medicamentos
Avaliação Pré-Clínica de Medicamentos
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: lil-623941
Autor: Xu, Ren-Sheng; Tang, Zong-Jian; Feng, Sheng-Chu; Yang, Yi-Ping; Lin, Wen-Han; Zhong, Qiong-Xing; Zhong, Yi.
Título: Studies on bioactive components from Chinese medicinal plants
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):55-59, 1991. ilus, tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Several novel bioactive components isolated from Chinese medicinal plants will be presented. These include novel maytansinoid tumor, inhibitors, some new ent-kaurane and rosane diterpenoids from Mallotus anomalus Meer et Chun (Euphorbiaceae), as well asnovel insecticide, stemona alkaloids from Stemona parviflora C. H. Wright (Stemonaceae). Both are native plants of Hainan island, Chine. 2D NMR techniques such as mono and hetero-COSY, NOESY, COLOC as well as H-NMR line broadening effect were utilized for structure elucidation. The separation techniques, struture elucidations and bioassay results will be reported.
Descritores: Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/química
Inseticidas/isolamento & purificação
Inseticidas/química
-Antitussígenos/isolamento & purificação
Antitussígenos/química
Medicamentos de Ervas Chinesas/uso terapêutico
Antineoplásicos
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/uso terapêutico
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME


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Id: lil-623932
Autor: Matos, F. J. A; Machado, M. I. L; Alencar, J. W; Matos, M. E. O; Craveiro, A. A.
Título: Plants used in traditional medicine of China and Brazil
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):13-16, 1991.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Eventhough the rationale behind the use of medicinal plantes in Brazil and Chine is different, twenty four species are used in both countries. Scientific name, vulgar name and uses in both countries along with their chemical constituents are listed.
Descritores: Medicamentos de Ervas Chinesas/uso terapêutico
Medicina Tradicional Chinesa/métodos
-Plantas/química
Brasil
China
Responsável: BR1.1 - BIREME


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Id: biblio-889068
Autor: Jiao, Yang; Wu, Yan; Du, Dong.
Título: Polydatin inhibits cell proliferation, invasion and migration, and induces cell apoptosis in hepatocellular carcinoma
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(4):e6867, 2018. graf.
Idioma: en.
Projeto: Innovative Research Program; . Science and Technology Program.
Resumo: Polydatin, a small molecule from Polygonum cuspidatum, has many biological functions, particularly anti-cancer effects. However, the anti-cancer effects of polydatin in hepatocellular carcinoma (HCC) have not been examined yet. In the present study, MTT assay, BrdU assay, transwell invasion assay, and wound healing assay were performed to determine cell proliferation, invasion and migration. Flow cytometry and TUNEL assay were used to measure cell apoptosis. Quantitative real-time PCR and western blotting assays were used to determine mRNA and protein expression levels. Xenograft experiment was performed to determine the in vivo anti-tumor effect of polydatin. Immunostaining was performed to analyze the expression of caspase-3 and Ki-67. Our results showed that polydatin inhibited cell proliferation in a concentration-dependent and time-dependent manner in the HCC cell lines. Polydatin also induced cell apoptosis in a concentration-dependent manner possibly via increasing the caspase-3 activity, and up-regulating the protein expression of caspase-3, caspase-9, Bax, and down-regulating the protein expression of Bcl-2. In addition, polydatin treatment had an inhibitory effect on cell proliferation, invasion and migration in HCC cell lines. Polydatin treatment also suppressed the Wnt/beta-catenin signaling activities in HCC cells. Polydatin treatment significantly reduced tumor growth in nude mice inoculated with HepG2 cells, suppressed the expression of Ki-67, and increased caspase-3 expression and TUNEL activity. Our data indicated the important role of polydatin for the suppression of HCC progression.
Descritores: Estilbenos/farmacologia
Movimento Celular/efeitos dos fármacos
Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/tratamento farmacológico
Proliferação Celular/efeitos dos fármacos
Glucosídeos/farmacologia
Neoplasias Hepáticas Experimentais/tratamento farmacológico
-Medicamentos de Ervas Chinesas
Western Blotting
Carcinoma Hepatocelular/patologia
Linhagem Celular Tumoral
Reação em Cadeia da Polimerase em Tempo Real
Citometria de Fluxo
Neoplasias Hepáticas Experimentais/patologia
Camundongos Endogâmicos BALB C
Camundongos Nus
Invasividade Neoplásica
Limites: Animais
Masculino
Camundongos
Responsável: BR1.1 - BIREME



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