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Pesquisa : D20.215.784.500.350 [Categoria DeCS]
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Id: biblio-1343489
Autor: Wang, Hong; Zhao, Chen-Yu; Zhu, Yong; Zhou, Ji-Pu; Yin, Wen; Li, Zhi-Yong; Yang, Xue-Qing; Qiu, Xin-Ping.
Título: The study of Yangyinyiqi mixture anti bleomycin-induced pulmonary fibrosis on rats by intervening matrix metalloproteinase-9 and tissue inhibitors of matrix metallopreoteinases-1 / El estudio de la mezcla Yangyinyiqi en fibrosis pulmonar inducida por anti-bleomicina en ratas por intervención en la matriz metaloproteinasa-9 e inhibidores de tejido de matriz metaloproteinasa-1
Fonte: Bol. latinoam. Caribe plantas med. aromát;20(3):315-323, may. 2021. ilus, tab.
Idioma: en.
Resumo: To investigate effectsof Yangyinyiqi Mixture on pulmonary fibrosis caused by bleomycin. SD ratswere divided randomly into: model group(distilled water,1 mL·0.1 kg-1), dexamethasone acetate group (dexamethasone acetate, the dosage was reduced gradually), low-dose group (Yangyinyiqi Mixture, 11 g·kg-1), moderate-dose group (Yangyinyiqi Mixture, 22 g·kg-1), high-dose group (Yangyinyiqi Mixture, 44 g·kg-1) and control group (distilled water, 1 mL·0.1 kg-1). Yangyinyiqi Mixture and dexamethasone acetate were intragastrically administrated. Lung tissue was collected for histopathological examination. Compared with control group, collagen markedly increased and HYP content significantly increased on 7th day in model group (p<0.01). On 28th day, collagen was diffusely deposited, alveolar was destroyed, and HYP content significantly increased (p<0.01). Compared with model group, bleomycin-induced suffering injury caused MMP-9 expression levels to rapidly increase (7and 14 days, p<0.01). TIMP-1 markedly increased (7and 14 days, p<0.01) and stayed at a high level to28th day. Yangyinyiqi Mixture exerted an effect against pulmonary fibrosis, which could involved prevention of collagen deposition through inhibitingMMP-9 and TIMP-1 expression.

El trabajo investiga los efectos de la mezcla Yangyinyiqi sobre la fibrosis pulmonary causada por bleomicina. Ratas SD se dividieron aleatoriamente en: grupo modelo (agua destilada, 1 mL·0.1 kg-1), grupo acetate de dexametasona (acetate de dexametasona, la dosis se redujo gradualmente), grupo de dosis baja (mezcla Yangyinyiqi, 11 g·kg-1), grupo de dosis moderada (mezcla Yangyinyiqi, 22 g·kg-1), grupo de dosis alta (mezcla Yangyinyiqi, 44 g·kg-1) y grupo control (agua destilada, 1 Ml·0.1 kg-1). La mezcla de Yangyinyiqi y el acetate de dexametasona se administraron por vía intragástrica. Se recolectó tejido pulmonary para examen histopatológico. En comparación con el grupo control, el colágeno aumentó notablemente y el contenido de HYP aumentó significativamente el séptimo día en el grupo modelo (p<0.01). El día 28, el colágeno se depositó difusamente, se produjo destrucción alveolar y el contenido de HYP aumento significativamente (p<0.01). En comparación con el grupo modelo, la lesión inducida por bleomicina causó que los niveles de expression de MMP-9 aumentaron rápidamente (7 y 14 días, p<0.01). TIMP-1 aumentó notablemente (7 y 14 días, p<0.01) y se mantuvo en un nivel alto hasta el día 28. La mezcla Yangyinyiqi ejerció un efecto contra la fibrosis pulmonary, lo que podría implicar la prevención del deposito de colágenio mediante la inhibición de la expression de MMP-9 y TIMP-1.
Descritores: Fibrose Pulmonar/tratamento farmacológico
Medicamentos de Ervas Chinesas/administração & dosagem
Inibidores Teciduais de Metaloproteinases/metabolismo
Metaloproteinase 9 da Matriz/metabolismo
-Bleomicina
Dexametasona/administração & dosagem
Western Blotting
Ratos Sprague-Dawley
Metaloproteinase 1 da Matriz
Modelos Animais de Doenças
Hidroxiprolina/análise
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1089352
Autor: Li, Rong; He, Miaoqing; Wu, Bing; Zhang, Peng; Zhang, Qinbin; Chen, Yangmei.
Título: SAD-B modulates epileptic seizure by regulating AMPA receptors in patients with temporal lobe epilepsy and in the PTZ-induced epileptic model
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;53(4):e9175, 2020. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China that funded our work.
Resumo: α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are the predominant mediators of glutamate-induced excitatory neurotransmission. It is widely accepted that AMPA receptors are critical for the generation and spread of epileptic seizure activity. Dysfunction of AMPA receptors as a causal factor in patients with intractable epilepsy results in neurotransmission failure. Brain-specific serine/threonine-protein kinase 1 (SAD-B), a serine-threonine kinase specifically expressed in the brain, has been shown to regulate AMPA receptor-mediated neurotransmission through a presynaptic mechanism. In cultured rat hippocampal neurons, the overexpression of SAD-B significantly increases the frequency of miniature excitatory postsynaptic currents (mEPSCs). Here, we showed that SAD-B downregulation exerted antiepileptic activity by regulating AMPA receptors in patients with temporal lobe epilepsy (TLE) and in the pentylenetetrazol (PTZ)-induced epileptic model. We first used immunoblotting and immunohistochemistry analysis to demonstrate that SAD-B expression was increased in the epileptic rat brain. Subsequently, to explore the function of SAD-B in epilepsy, we used siRNA to knock down SAD-B protein and observed behavior after PTZ-induced seizures. We found that SAD-B downregulation attenuated seizure severity and susceptibility in the PTZ-induced epileptic model. Furthermore, we showed that the antiepileptic effect of SAD-B downregulation on PTZ-induced seizure was abolished by CNQX (an AMPA receptor inhibitor), suggesting that SAD-B modulated epileptic seizure by regulating AMPA receptors in the brain. Taken together, these findings suggest that SAD-B may be a potential and novel therapeutic target to limit epileptic seizures.
Descritores: Medicamentos de Ervas Chinesas/uso terapêutico
Proteínas Serina-Treonina Quinases/metabolismo
Receptores de AMPA/metabolismo
Agonistas de Aminoácidos Excitatórios/metabolismo
Epilepsia do Lobo Temporal/tratamento farmacológico
-Pentilenotetrazol
Ratos Sprague-Dawley
Epilepsia do Lobo Temporal/induzido quimicamente
Limites: Humanos
Animais
Masculino
Feminino
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1284301
Autor: Tan, Li; Li, Xiao-Xu; Chu, Xi-Ying; Li, Yan; Wan, Li-Jing.
Título: Impact of Kuntai Capsules on LIF, IGF-1 and EGF expression in the implantation window of endometrium in mice / Impacto de cápsulas de Kuntai en la expresión de LIF, IGF-1 y EGF en la ventana de implantación de endometrio en ratones
Fonte: Bol. latinoam. Caribe plantas med. aromát;19(6):591-600, 2020. tab, ilus.
Idioma: en.
Resumo: To investigate the influence of Kuntai capsules on the expression level of leukemia inhibitory factor (LIF), insulin-like growth factor-I (IGF-1)and epidermal growth factor (EGF) during the mouse's implantation window of superovulation period and controlled ovarian hyperstimulation period. 90 female mice were randomly divided into six groups in control, superovulation and controlled ovarian hyperstimulation (COH) conditions. The RNA expression of EGF, LIF and IGF-1 in the endometrium on the 4th day of pregnancy was detected, and the relative expression was compared. mRNA expression of these three factors in endometrium was significantly lower in superovulation and COH groups than control group (p<0.001). mRNA expression of these three factors in endometrium remained obviously lower in superovulation plus kuntai capsule group and COH plus kuntai capsule group than control group (p<0.01). mRNA expression of these three factors in endometrium was lower in control group than in the NS plus kuntai capsule group (p<0.05). Kuntai capsule cannot completely reverse the endometrial damages caused by superovulation and COH. Thus Kuntai capsule could partially improve a mouse's endometrial receptivity during the implantation window.

Para investigar la influencia de las cápsulas de Kuntai en el nivel de expresión del factor inhibidor de la leucemia (LIF), el factor de crecimiento similar a la insulina I (IGF-1) y el factor de crecimiento epidérmico (EGF) durante la ventana de implantación del ratón del período de superovulación y la hiperestimulación ovárica controlada período, se dividieron aleatoriamente 90 ratones hembra en seis grupos en condiciones de control, superovulación e hiperestimulación ovárica controlada (COH). Se detectó la expresión de ARN de EGF, LIF e IGF-1en el endometrio al cuarto día de embarazo, y se comparó la expresión relativa. La expresión de ARNm de estos tres factores en el endometrio fue significativamente menor en los grupos de superovulación y COH que en el grupo control (p<0,001). La expresión de ARNm de estos tres factores en el endometrio permaneció más baja en el grupo de cápsulas de superovulación más Kuntai y en el grupo de cápsulas de COH más Kuntai respecto del grupo control (p<0,01). La expresión de ARNm de estos tres factores en el endometrio fue menor en el grupo control que en el grupo de cápsula NS más Kuntai (p<0,05). La cápsula de Kuntai no pudo revertir completamente los daños endometriales causados por la superovulación y la COH. Por lo tanto, se sugiere que la cápsula de Kuntai podría mejorar parcialmente la receptividad endometrial de un ratón durante la ventana de implantación.
Descritores: Indução da Ovulação/métodos
Somatomedinas/efeitos dos fármacos
Medicamentos de Ervas Chinesas/farmacologia
Fator de Crescimento Epidérmico/efeitos dos fármacos
Fator Inibidor de Leucemia/efeitos dos fármacos
-Implantação do Embrião
Superovulação
Somatomedinas/genética
Somatomedinas/metabolismo
Cápsulas
Reação em Cadeia da Polimerase/métodos
Eletroforese
Fator de Crescimento Epidérmico/genética
Fator de Crescimento Epidérmico/metabolismo
Fator Inibidor de Leucemia/genética
Fator Inibidor de Leucemia/metabolismo
Limites: Animais
Feminino
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950773
Autor: Bae, Seunghee; Jung, Younjung; Choi, Yeong Min; Li, Shunhua.
Título: Effects of Er-Miao-San extracts on TNF-alpha-indueed MMP-1 expression in human dermal fibroblasts
Fonte: Biol. Res;48:1-8, 2015. graf.
Idioma: en.
Projeto: Korean Health Technology R& D Project; . Ministry of Health & Welfare.
Resumo: BACKGROUND: Various health benefits have been attributed to Er-Miao-San (EMS), a traditional Chinese herbal formulation that contains equal amounts of cortex phellodendri (Phellodendron amurense Ruprecht) and rhizoma atractylodis (Atractylodes lancea D.C). However, its effect on the anti-inflammatory activity in human dermal fibroblasts (HDFs) and the mechanism underlying this effect are unknown. RESULTS: This study investigated the effects of EMS on TNF-α-induced MMP-1 expression in HDFs. Our data show that EMS inhibited TNF-α-induced MMP-1 expression in a concentration-dependent manner. Interestingly, EMS maintained IkB content without inhibiting the phosphorylation of MAPKs, which are well-established upstream kinases of NF-kB. Moreover, EMS reduced the level of nuclear p65 protein in HDFs. Luciferase assay revealed that EMS inhibits the transcriptional activity of NF-kBbystabilizing IkB. Our results show that EMS exerts its anti-inflammatory effect by inhibiting NF-kB-regulated genes such as IL-1ß and IL-8. Moreover, EMS effectively inhibited TNF-α-induced expression of MMP-1 via the NF-kBpathway. CONCLUSIONS: Taken together, our data suggest that EMS could potentially be used as an anti-inflammatory and anti-aging treatment.
Descritores: Envelhecimento/efeitos dos fármacos
Medicamentos de Ervas Chinesas/farmacologia
Extratos Vegetais/farmacologia
Derme/citologia
Metaloproteinase 1 da Matriz/biossíntese
Fibroblastos/efeitos dos fármacos
-Transdução de Sinais/efeitos dos fármacos
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Indução Enzimática/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Interleucina-8/efeitos dos fármacos
Interleucina-8/metabolismo
NF-kappa B/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Proteínas Quinases Ativadas por Mitógeno/efeitos dos fármacos
Interleucina-1beta/efeitos dos fármacos
Interleucina-1beta/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Fibroblastos/enzimologia
Anti-Inflamatórios/administração & dosagem
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1137304
Autor: Yin, Shijie; Feng, Zhiqiang; Mo, Ansheng; Ding, Yi; Wu, Jun.
Título: Effect of shenfu injection on isolated empty beating hearts from miniature pigs
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);35(4):484-489, July-Aug. 2020. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . National Natural Science Foundation of Guangxi.
Resumo: Abstract Objective: To investigate the effect of Shenfu (SF) injection on donor heart preservation. Methods: Twelve pigs were randomly divided into SF group (n=6) and control group (n=6). After eight hours of perfusion, the differences in hemoglobin, the expression of Bcl-2 and BAX, and changes in the myocardial ultrastructure were compared to illustrate the effects of SF injection in heart preservation. Results: The differences in free hemoglobin between the SF group and the control group were statistically significant (P=0.001), and there was significant interaction of groups with times (P=0.019), but the perfusion time may not be associated with the hemoglobin concentration (P=0.616). According to Western blotting analysis, the expression of Bcl-2 was higher in the SF group than in the control group, while the expression of BAX was not different between the two groups. As to ultrastructural changes, both groups exhibited mitochondrial swelling and myofilament lysis, but the degree of damage in the SF group was smaller. Conclusion: Our study suggests that the application of SF injection for heart preservation may protect against cardiomyocytes and erythrocytes apoptosis, and Bcl-2 protein may play a role in these physiological processes.
Descritores: Medicamentos de Ervas Chinesas
Transplante de Coração
-Suínos
Porco Miniatura
Doadores de Tecidos
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: biblio-896349
Autor: He, Jianxin; Si, Xiaoshui; Ji, Mingxia; Huang, Jing; Zheng, Wenjuan; Wang, Jiao; Wang, Junfeng; Zhu, Lijun.
Título: Effect of rhubarb on extravascular lung water in patients with acute respiratory distress syndrome
Fonte: Rev. Assoc. Med. Bras. (1992);63(5):435-440, May 2017. tab, graf.
Idioma: en.
Resumo: Summary Objective: The aim of this study was to evaluate the effect of rhubarb on extravascular lung water (EVLW) in patients with acute respiratory distress syndrome (ARDS). Method: A total of 80 patients with ARDS were randomly divided into a treatment group (40 cases) and control group (40 cases). Patients in the treatment group received rhubarb (30.0 g/d) and patients in the control group received conventional therapy for seven consecutive days. Extravascular lung water index (EVLWI) and pulmonary vascular permeability index (PVPI) were determined using pulse contour cardiac output (PiCCO) technology, and the oxygenation index was measured by blood gas analysis at baseline and on days 3, 5 and 7 after treatment. Results: The oxygenation index was higher and the levels of EVLWI and PVPI were lower after treatment in the two groups; however, these indexes showed significant differences on the 5th and 7th days after rhubarb treatment compared with the results in the control group (p<0.05). Conclusion: Rhubarb can decrease EVLWI and PVPI, and improve oxygenation in patients with ARDS.
Descritores: Síndrome do Desconforto Respiratório/tratamento farmacológico
Rheum/química
Medicamentos de Ervas Chinesas/uso terapêutico
Água Extravascular Pulmonar/efeitos dos fármacos
-Oxigênio/fisiologia
Edema Pulmonar/tratamento farmacológico
Síndrome do Desconforto Respiratório/fisiopatologia
Fatores de Tempo
Gasometria
Permeabilidade Capilar/efeitos dos fármacos
Permeabilidade Capilar/fisiologia
Débito Cardíaco/efeitos dos fármacos
Débito Cardíaco/fisiologia
Água Extravascular Pulmonar/fisiologia
Reprodutibilidade dos Testes
Análise de Variância
Resultado do Tratamento
Pulmão/efeitos dos fármacos
Pulmão/fisiopatologia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Adulto Jovem
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-950844
Autor: Geng, Wenjia; Wei, Ribao; Liu, Shuwen; Tang, Li; Zhu, Hanyu; Chen, Pu; Wu, Jie; Zhang, Xueguang; Zhu, Fei; Yin, Zhong; Chen, Xiangmei.
Título: Shenhua Tablet inhibits mesangial cell proliferation in rats with chronic anti-Thy-1 nephritis
Fonte: Biol. Res;49:1-10, 2016. ilus, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . China Postdoctoral Science Foundation; . National Natural Science Foundation of China.
Resumo: BACKGROUND: In China, mesangial proliferative glomerulonephritis (MsPGN) is one of the most common kidney diseases. In this study, we treated a rat model of chronic anti-Thy-1 MsPGN with Shenhua Tablet and evaluated whether the tablet was able to protect the kidney function. Thirty-six Wistar rats were randomly divided into six groups: (1) Sham surgery (Sham); (2) anti-Thy-1 nephritis model (Thy-1); (3) anti-Thy-1 nephritis model + irbesartan-treated (Irb); (4) anti-Thy-1 nephritis model + low-dose of Shenhua Tablet (SHL); (5) anti-Thy-1 nephritis model + medium-dose of Shenhua Tablet (SHM); (6) anti-Thy-1 nephritis model + high-dose of Shenhua Tablet (SHH). RESULTS: Thirteen weeks after drug treatment, urinary proteins were quantified and renal pathological changes were thoroughly examined at the time point of 24 h. Meanwhile, the expression levels of p-Erk1/2, cyclin D1 and p21 at the renal cortex were also tested. The levels of urinary proteins and total cholesterol in the blood were significantly reduced in rats treated with any drug tested in this study. The level of triglyceride was significantly reduced in all three Shenhua Tablet-treated groups. Renal pathomorphological scores were significantly improved in groups of Irb, SHM and SHH. Mesangial cell proliferation was significantly inhibited in any drug-treated group. p-Erk1/2 and cyclin D1 were downregulated whereas p21 was upregulated in the renal cortex. CONCLUSIONS: Our study indicated that Shenhua Tablet is able to inhibit the abnormal proliferation of mesangial cells and to prevent kidney damage, which is likely associated with downregulation of p-Erk1/2 and reduced activity of its downstream target-cyclin D1.
Descritores: Medicamentos de Ervas Chinesas/farmacologia
Glomerulonefrite Membranoproliferativa/tratamento farmacológico
Proliferação de Células/efeitos dos fármacos
Células Mesangiais/efeitos dos fármacos
Isoanticorpos
-Fatores de Tempo
Albumina Sérica/análise
Medicamentos de Ervas Chinesas/uso terapêutico
Glomerulonefrite Membranoproliferativa/patologia
Doença Crônica
Reprodutibilidade dos Testes
Ratos Wistar
Proteína Quinase 1 Ativada por Mitógeno/análise
Ciclina D1/análise
Computadores de Mão
Quinases Ativadas por p21/análise
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-950867
Autor: Hwan-Hee, Jang; Su-Yeon, Cho; Mi-Ju, Kim; Jung-Bong, Kim; Sung-Hyen, Lee; Mee-Young, Lee; Young-Min, Lee.
Título: Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model
Fonte: Biol. Res;49:1-11, 2016. ilus, graf.
Idioma: en.
Projeto: National Institute of Agricultural Science of Rural Development Administration.
Resumo: BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-α and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an ovalbumin (OVA)-induced BALB/c mouse model. SE-A treatment significantly reduced the number of airway eosinophils, IL-4 and IL-13 levels, mucus production, and inflammatory infiltration, as compared with the corresponding levels in the untreated, OVA-induced mice, and had similar effects to dexamethasone CONCLUSIONS: Salvia plebeia ethanol extract ameliorated the induced inflammatory response in RAW 264.7 and BEAS-2B cells, with more effective inhibition noted for SE-A than for SE-R. SE-A treatment was effective in improving the histopathological changes in the lungs of asthma model mice via modulation of eosinophils and Th2 cytokines. These results suggest that SE-A can be considered as a therapeutic agent that can potentially relieve asthma
Descritores: Asma/tratamento farmacológico
Medicamentos de Ervas Chinesas/farmacologia
Antiasmáticos/farmacologia
Anti-Inflamatórios/farmacologia
-Asma/induzido quimicamente
Ensaio de Imunoadsorção Enzimática
Células Cultivadas
Ovalbumina
Lipopolissacarídeos/farmacologia
Reprodutibilidade dos Testes
Citocinas/análise
Citocinas/efeitos dos fármacos
Componentes Aéreos da Planta/química
Modelos Animais de Doenças
Etanol/farmacologia
Reação em Cadeia da Polimerase em Tempo Real
Células RAW 264.7
Pulmão/efeitos dos fármacos
Pulmão/fisiologia
Camundongos Endogâmicos BALB C
Óxido Nítrico/análise
Limites: Animais
Feminino
Camundongos
Tipo de Publ: Estudo de Avaliação
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1136296
Autor: Jin, Lairun; Xu, Yan; Yuan, Hui.
Título: Effects of four types of integrated Chinese and Western medicines for the treatment of COVID-19 in China: a network meta-analysis
Fonte: Rev. Assoc. Med. Bras. (1992);66(6):771-777, June 2020. tab, graf.
Idioma: en.
Resumo: SUMMARY OBJECTIVE Various integrated Chinese and Western medicines might be beneficial for the treatment of Coronavirus disease 2019 (COVID-19). This study aims to evaluate the efficacy of lung computed tomography (CT) of four integrated Chinese and Western medicines in the treatment of COVID-19 using network meta-analysis (NMA). METHODS Multiple databases were consulted to find randomized controlled trials of four different types of integrated Chinese and Western medicines for the treatment of COVID-19. NMA was conducted on the data using Stata (13.0) software. The odds ratio (OR) was calculated. The studies included in this paper were divided into a control group (Western medicine) and an observation group (one of four integrated Chinese and Western medicines). RESULTS 5 eligible publications were identified. A total of 598 cases were included in the study, and the results showed that the four types of integrated Chinese and Western medicines (symptomatic and supportive care with Qingfei Touxie Fuzheng, Lianhua Qingke, and Xuebijing) were significantly superior (P < 0.05) to symptomatic and supportive care alone, except for symptomatic and supportive care with Lianhua Qingwen. The combination of symptomatic and supportive care with Lianhua Qingke had the highest probability of being the most clinically efficacious intervention, with a surface under the cumulative ranking (SUCRA) curve of 85.7. CONCLUSIONS A combination of symptomatic and supportive care with Lianhua Qingke is the best option among the four integrated Chinese and Western medicines considered for the treatment of COVID-19.

RESUMO OBJETIVO Vários medicamentos chineses e ocidentais integrados podem ser benéficos para o tratamento da COVID-19. O objetivo deste estudo é avaliar a eficácia da tomografia computadorizada (TC) de pulmão de quatro medicamentos chineses e ocidentais integrados para o tratamento da COVID-19 usando uma meta-análise em rede (NMA). MÉTODOS Vários bancos de dados foram consultados para encontrar ensaios clínicos randomizados de quatro tipos diferentes de medicamentos chineses e ocidentais integrados para o tratamento da COVID-19. A NMA foi realizada nos dados usando o software Stata (13.0). O odds ratio (OR) foi calculado. Os estudos incluídos neste artigo foram divididos em um grupo de controle (medicina ocidental) e um grupo de observação (um dos quatro medicamentos chineses e ocidentais integrados). RESULTADOS 5 publicações elegíveis foram identificadas. Um total de 598 casos foram incluídos no estudo, e os resultados mostraram que os quatro tipos de medicamentos chineses e ocidentais integrados (tratamento sintomático e de suporte com Qingfei Touxie Fuzheng, Lianhua Qingke e Xuebijing) foram significativamente superiores (P <0,05) a somente cuidados sintomáticos e de suporte, exceto cuidados sintomáticos e de suporte com Lianhua Qingwen. A combinação de cuidados sintomáticos e de suporte com Lianhua Qingke teve a maior probabilidade de ser a intervenção clinicamente mais eficaz, com uma superfície abaixo da curva de classificação cumulativa (SUCRA) de 85,7. CONCLUSÕES Uma combinação de tratamento sintomático e de suporte com Lianhua Qingke é a melhor opção entre os quatro medicamentos integrados chineses e ocidentais considerados para o tratamento de COVID-19.
Descritores: Pneumonia Viral/terapia
Medicamentos de Ervas Chinesas
Infecções por Coronavirus/tratamento farmacológico
Infecções por Coronavirus/terapia
Coronavirus
Pandemias
-China
Infecções por Coronavirus
Metanálise em Rede
Betacoronavirus
Limites: Humanos
Tipo de Publ: Metanálise
Responsável: BR1.1 - BIREME


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Id: lil-731288
Autor: Melo, Maykon Diego; Egry, Emiko Yoshikawa.
Título: Social determinants of hospitalizations for ambulatory care sensitive conditions in Guarulhos, São Paulo / Los determinantes sociales de las hospitalizaciones por condiciones sensibles a la atención primaria en guarulhos, são paulo / Determinantes sociais das Internações por Condições Sensíveis à Atenção Primária em Guarulhos, São Paulo
Fonte: Rev. Esc. Enferm. USP;48(spe):129-136, 08/2014. tab.
Idioma: en.
Resumo: The study goals present an overview of Hospitalizations for Ambulatory Care Sensitive Conditions (ACSC) in Guarulhos, SP, from 2008 to 2012. This is an ecological study based on secondary data obtained from the Brazilian Hospital Information System, and supported by the Praxical Theory of Intervention of Collective Health Nursing. Applied descriptive statistics for analysis. It was observed that Guarulhos shows an upward trend in hospitalizations by ACSC (20% increase), the most frequent causes of heart failure (11.8%), cerebrovascular disease (10.6%) and angina (9.7%), most frequently in the age group ≥ 65years old, for both sexes. The results are similar to other Brazilian studies, but their analysis should extrapolate the biological limits and the supply of healthcare resources, focusing on the social determinants of the health-disease process.


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El estudio tuvo como objetivo proporcionar una visión general de las Hospitalizaciones por Condiciones Sensibles a la Atención Primaria (ICSAP) en Guarulhos, SP, en el período 2008-2012. Se trata de un estudio ecológico a partir de datos secundarios obtenidos a través del Sistema de Información Hospitalaria, y apoyado por la Teoría de Intervención Práxica de la Enfermería en Salud Colectiva. Se aplicó la estadística descriptiva para el análisis. Se observó que Guarulhos muestra una tendencia al alza en las hospitalizaciones por ICSAP (aumento del 20%), las causas más frecuentes de insuficiencia cardiaca (11,8%), enfermedad cerebrovascular (10,6%) y la angina (9,7% ), con mayor frecuencia en el grupo de edad ≥ 65 años para ambos sexos. Los resultados son similares a otros estudios brasileños, pero su análisis debe extrapolar los límites biológicos y el suministro de los recursos sanitarios, centrándose en los determinantes sociales del proceso salud-enfermedad.
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Objetivo Apresentar o panorama das Internações por Condições Sensíveis à Atenção Primária (ICSAP) no município de Guarulhos, SP, no período de 2008 a 2012. Método Estudo ecológico, com dados secundários obtidos via Sistema de Informações Hospitalares, sustentado pela Teoria de Intervenção Práxica da Enfermagem em Saúde Coletiva. Empregou-se estatística descritiva para análise. Resultados Observou-se que Guarulhos apresenta trajetória crescente nas internações por ICSAP (aumento de 20%), sendo as causas mais frequentes a insuficiência cardíaca (11,8%), as doenças cerebrovasculares (10,6%) e a angina (9,7%), com maior frequência na faixa etária ≥ 65 anos, para ambos os sexos. Conclusão Os resultados encontrados assemelham-se a outros estudos brasileiros, porém sua análise deve extrapolar os limites biológicos e a oferta de recursos assistenciais, atentando para as determinações sociais do processo saúde-doença. .
Descritores: Medicamentos de Ervas Chinesas/uso terapêutico
Fitoterapia
Lesões Pré-Cancerosas/tratamento farmacológico
Neoplasias Gástricas/tratamento farmacológico
-Mucosa Gástrica/irrigação sanguínea
Mucosa Gástrica/efeitos dos fármacos
Mucosa Gástrica/patologia
Hexosaminas/metabolismo
Malondialdeído/metabolismo
Lesões Pré-Cancerosas/irrigação sanguínea
Lesões Pré-Cancerosas/patologia
Ratos Wistar
Neoplasias Gástricas/irrigação sanguínea
Neoplasias Gástricas/patologia
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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