Base de dados : LILACS
Pesquisa : D20.777 [Categoria DeCS]
Referências encontradas : 51 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 6 ir para página                

  1 / 51 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Id: lil-724550
Autor: Durand Velazco, José Carlos.
Título: Estudio del perfil lipídico y tejido cardiovascular en ratas alimentadas con grasa Light / Study of lipid profile and cardiovascular tissue in rats fed with fat Light.
Fonte: Lima; s.n; 2013. 70 p. ilus, tab, graf.
Idioma: es.
Tese: Apresentada a Universidad Nacional Mayor de San Marcos. Facultad de Medicina para obtenção do grau de Maestría.
Resumo: OBJETIVO: Determinar los efectos deletéreos de los ácidos grasas constituyentes del aceite y/o grasa denominada comercialmente "Light" sobre el perfil lipídico y tejido cardiovascular de ratas albinas sometidas a dietas con requerimientos normales durante 45 días de experimentación. MATERIAL y METODOS: Se trabajó con 30 ratas machos de 21 días de edad, de raza Wistar, distribuidas en tres grupos. Se les proporcionó dietas con energía y proteínas de acuerdo a sus requerimientos durante 45 días. El primer grupo recibió como fuente de ácidos grasas los provenientes de Aceite Vegetal de Cocina (dieta A), el segundo grupo Aceite Vegetal de Cocina denominada "Light" (dieta B) y el tercer grupo Margarina Vegetal denominada "Light" (dieta C). RESULTADOS: Se registró un incremento de peso en los tres grupos y hubo diferencias significativas en la composición corporal (p<0.05) en el grupo alimentado con Margarina Vegetal "Light" (dieta C) comparados con los otros dos grupos (dietas A y B). En los animales alimentados con ácidos grasas constituyentes de la Margarina "Light" (Dieta C) se encontró histológicamente en las fibras musculares una reducción de los paquetes musculares en relación con los otros grupos de Animales, presentando significancia estadística (p<0.01), de igual forma se presentó Disminución de la capa media (compuesta de músculo liso) y luz de la arteria con significancia estadística (p<0.01). En relación a los componentes del perfil lipídico, en los animales alimentados con la dieta A (Colesterol Total, Triglicéridos, Colesterol HDL, Colesterol LDL y Colesterol VLDL), también se presentaron cambios con significancia estadística (p<0.05). CONCLUSIONES: Ratas alimentadas con dietas que incluían ácidos grasas provenientes de la grasa tipo Margarina Vegetal "Light" (Dieta C), presentaron trastornos en la composición corporal, variaciones en el perfil lipídico, con discreto foco degenerativo y reducción del paquete muscular cardíaco.

OBJECTIVE: To determine the deleterious effect of fatty acids included in commercially called 'Light' oil and/or fats upon the lipid profile and cardiovascular tissue in albino rats who received diet complying with the normal requirement during 45 days. MATERIAL AND METHODS: We carried out the trial in 30 male Wistar rats aged 21 days old. The animals were divided in three groups. They received a diet complying with energy and protein requirements during 45 days. The first group received vegetable cooking oil (diet A) as a source of fatty acids, the second group received 'Light' cooking vegetable oil (diet B), and the third group received 'Light' vegetable margarine (diet C). RESULTS: Weight gain was observed in the three groups, and there were significant differences in the body composition (p<0.05) in the group of animals receiving 'Light' vegetable margarine (diet C), compared with the other two groups (diets A and B).Histological studies in the animals that received fatty acids included in 'Light' margarine (diet C) there was a reduction in muscle bundles compared to the other groups, with statistical significance (p<0.01), and also there was a reduction in the media layer (with smooth muscle) and in the arterial lumen, also with statistical significance (p<0.01). With respect to the lipid profile (total cholesterol, HDL-LDL-, and VLDL-cholesterol), the animals that received diet A also had statistically significant changes (p<0.05). CONCLUSIONS: Rats fed with diets containing fatty acids derived from 'Light' vegetable margarine (diet C) had changes in their body composition, in the lipid profile, and mild degenerative changes and a reduction in cardiac muscle mass.
Descritores: Alimentos Formulados
Experimentação Animal
Extratos de Tecidos
Lipídeos/análise
Sistema Cardiovascular/anatomia & histologia
Substitutos da Gordura
-Epidemiologia Experimental
Estudos Longitudinais
Estudos Prospectivos
Limites: Masculino
Animais
Ratos
Responsável: PE13.1 - Oficina de Biblioteca, Hemeroteca y Centro de Documentación
PE13.1; MG, QU, 86, D98, ej.1. 010000094144; PE13.1; MG, QU, 86, D98, ej.2. 010000094145


  2 / 51 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-886265
Autor: Andrade, Paulo Henrique Muleta; Portugal, Luciane Canderolo; Rondon, Eric Schmidt; Kadri, Monica Cristina Toffoli; Matos, Maria de Fátima Cepa.
Título: Effect of powdered shells treatment of the snail Megalobulimus lopesi on wounds of diabetic rats
Fonte: Acta cir. bras;33(2):185-196, Feb. 2018. graf.
Idioma: en.
Resumo: Abstract Purpose: To analyzed the healing effect of the powdered shell of the Megalobulimus lopesi snail on wounds of diabetic rats, since in non-diabetic rats the powdered shell presented healing potential. Methods: Seventy-two Wistar rats (Rattus norvegicus albinus) were divided into three groups: Control group (GC.diab), no therapeutic intervention on the wound; Vehicle's Control group, topical via, in diabetic rats (GCvt.diab): Powder Shell Group (PC) applied topically (GPCvt.diab): Experimental group was administered topically shortly after wound dressing and once a day during the experimental period (3, 7, 14 and 21 days) the composition containing the powdered shell of the snail. The following variables related to the healing potential were analyzed: macroscopic one, where the capacity of reduction of the wound area was evaluated; histological analysis in HE, angiogenic activity, morphometric analysis (re-epithelization), leukocyte inflammatory infiltrate; leukocyte count and also differentiation in peripheral blood. Results: The topical application in wounds of diabetic rats presented healing activity, accelerating wound closure, stimulating angiogenesis and being pro-inflammatory in the early and anti-inflammatory stages in the final times of the healing process. Conclusion: The topical administration of the powdered shell on wounds of diabetic patients becomes a therapeutic option of low cost, with ease in the administration and access as well.
Descritores: Caramujos
Extratos de Tecidos/farmacologia
Cicatrização/efeitos dos fármacos
Diabetes Mellitus Experimental/fisiopatologia
Exoesqueleto/química
Anti-Inflamatórios/farmacologia
-Pós
Extratos de Tecidos/administração & dosagem
Administração Tópica
Ratos Wistar
Modelos Animais de Doenças
Reepitelização
Anti-Inflamatórios/administração & dosagem
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  3 / 51 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-889106
Autor: Jasso-Villagomez, EI; Garcia-Lorenzana, M; Almanza-Perez, JC; Fortis-Barrera, MA; Blancas-Flores, G; Roman-Ramos, R; Prado-Barragan, LA; Alarcon-Aguilar, FJ.
Título: Beetle (Ulomoides dermestoides) fat improves diabetes: effect on liver and pancreatic architecture and on PPARgamma expression
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(6):e7238, 2018. tab, graf.
Idioma: en.
Projeto: CONACyT; . PROMEP-SEP.
Resumo: Ulomoides dermestoides is a beetle traditionally consumed to treat diabetes. In this study, we performed a composition analysis of U. dermestoides to obtain the principal fractions, which were used to assess the effect on glycemia, liver and pancreatic architecture, and PPARγ and GLUT4 expression. Normal mice and alloxan-induced diabetic mice were administered fractions of chitin, protein or fat, and the acute hypoglycemic effect was evaluated. A subacute study involving daily administration of these fractions to diabetic mice was also performed over 30 days, after which the liver and pancreas were processed by conventional histological techniques and stained with hematoxylin and eosin to evaluate morphological changes. The most active fraction, the fat fraction, was analyzed by gas chromatography-mass spectrometry (GC-MS), and PPARγ and GLUT4 mRNA expressions were determined in 3T3-L1 adipocytes. The protein and fat fractions exhibited hypoglycemic effects in the acute as well as in the 30-day study. Only the fat fraction led to elevated insulin levels and reduced glycemia, as well as lower intake of water and food. In the liver, we observed recovery of close hepatic cords in the central lobule vein following treatment with the fat fraction, while in the pancreas there was an increased density and percentage of islets and number of cells per islet, suggesting cellular regeneration. The GC-MS analysis of fat revealed three fatty acids as the major components. Finally, increased expression of PPARγ and GLUT4 was observed in 3T3-L1 adipocytes, indicating an antidiabetic effect.
Descritores: Pâncreas/efeitos dos fármacos
Extratos de Tecidos/uso terapêutico
Besouros/química
Corpo Adiposo/química
Hipoglicemiantes/uso terapêutico
Fígado/efeitos dos fármacos
-Pâncreas/metabolismo
Pâncreas/patologia
Extratos de Tecidos/isolamento & purificação
RNA Mensageiro/efeitos dos fármacos
RNA Mensageiro/metabolismo
Regulação da Expressão Gênica
PPAR gama/efeitos dos fármacos
PPAR gama/metabolismo
Diabetes Mellitus Experimental/metabolismo
Diabetes Mellitus Experimental/patologia
Diabetes Mellitus Experimental/tratamento farmacológico
Transportador de Glucose Tipo 4/efeitos dos fármacos
Transportador de Glucose Tipo 4/metabolismo
Hipoglicemiantes/isolamento & purificação
Fígado/metabolismo
Fígado/patologia
Cromatografia Gasosa-Espectrometria de Massas
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  4 / 51 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-761841
Autor: Vargas Sánchez, Paula K; Delgado Mejía, Edgar; Torres Rodríguez, Carolina.
Título: Effect of a new remineralizing biomaterial on the color of dental enamel
Fonte: Acta odontol. latinoam;27(1):3-8, July 2014. tab, graf.
Idioma: en.
Resumo: El objetivo de este trabajo fue describir el efecto de la composición de una sustancia remineralizante (SRM) y de la presión osmótica sobre el color dental mediante espectrofotometría. Se tomaron 104 premolares y molares humanos repartidos aleatoriamente en 2 grupos, cada uno de 52 especímenes. El grupo 1 se trató con la sustancia remineralizante SRM 55 (agente remineralizante 1) mezcla de 50 por ciento - 50 por ciento de mineral de grano fino y otro mineral de grano grueso y el grupo 2 se trató con la sustancia remineralizante SRM 91(agente remineralizante 2) contienen los mismos minerales en proporción 90 por ciento - 10 por ciento. A su vez cada grupo se dividió en 2 subgrupos, cada uno de 26 especímenes que se almacenaron así: Un subgrupo en saliva sintética con presión osmótica isotónica (PI) y el otro con presión osmótica hipotónica (PH). Se tomaron registros iniciales y finales con el espectrofotómetro Vita Easy Shade®. Con las lecturas se calcularon losparámetros de color (L*; a*; b*) y los índices de blanqueamiento (WIC; WIO; W). Los cambios de color (ΔL; ΔA; ΔB; yΔE) y los índices de blanqueamiento se compararon y se trataron todos mediante un análisis descriptivo. Las variables ΔA, ΔL, ΔB, ΔE e índice de blanqueamiento W se trataron con ANOVA y los índices WIC y WIO con un análisis de varianza no paramétrico Kruskal Wallis. Los resultados indican que la combinación A2 (SRM 91 y PI) afectó las variables ΔB y ΔE. La combinación B1 (SRM 55 Y PH) afectó las variables ΔA, ΔB y el índice de blanqueamiento WIO. Solamente SRM 91afectó la variable ΔL. La presión osmótica de la saliva y la sustancia remineralizante afectan el color del esmalte dental...
Descritores: Esmalte Dentário
Materiais Biocompatíveis/farmacologia
Remineralização Dentária/métodos
-Cor
Casca de Ovo/química
Espectrofotometria/métodos
Extratos de Tecidos/farmacologia
Fosfatos/farmacologia
Pressão Osmótica
Profilaxia Dentária/instrumentação
Saliva Artificial
Soluções Hipotônicas/química
Soluções Isotônicas/química
Limites: Humanos
Masculino
Adolescente
Adulto
Animais
Feminino
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Responsável: AR29.1 - Biblioteca


  5 / 51 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Brandäo, Lucinda Giampietro
Abrao, Emiliana Pereira
Texto completo
Id: lil-703647
Autor: Maruyama, Sandra Regina; Castro-Jorge, Luiza Antunes; Ribeiro, Jose Marcos Chaves; Gardinassi, Luiz Gustavo; Garcia, Gustavo Rocha; Brandao, Lucinda Giampietro; Rodrigues, Aline Rezende; Okada, Marcos Ituo; Abrao, Emiliana Pereira; Ferreira, Beatriz Rossetti; Fonseca, Benedito Antonio Lopes da; Miranda-Santos, Isabel Kinney Ferreira de.
Título: Characterisation of divergent flavivirus NS3 and NS5 protein sequences detected in Rhipicephalus microplus ticks from Brazil
Fonte: Mem. Inst. Oswaldo Cruz;109(1):38-50, 02/2014. tab, graf.
Idioma: en.
Projeto: FAPESP; . FAPESP; . FAPESP; . FAPESP; . FAPESP; . FAPESP; . CNPq; . CNPq; . CNPq; . CNPq; . CNPq.
Resumo: Transcripts similar to those that encode the nonstructural (NS) proteins NS3 and NS5 from flaviviruses were found in a salivary gland (SG) complementary DNA (cDNA) library from the cattle tick Rhipicephalus microplus. Tick extracts were cultured with cells to enable the isolation of viruses capable of replicating in cultured invertebrate and vertebrate cells. Deep sequencing of the viral RNA isolated from culture supernatants provided the complete coding sequences for the NS3 and NS5 proteins and their molecular characterisation confirmed similarity with the NS3 and NS5 sequences from other flaviviruses. Despite this similarity, phylogenetic analyses revealed that this potentially novel virus may be a highly divergent member of the genus Flavivirus. Interestingly, we detected the divergent NS3 and NS5 sequences in ticks collected from several dairy farms widely distributed throughout three regions of Brazil. This is the first report of flavivirus-like transcripts in R. microplus ticks. This novel virus is a potential arbovirus because it replicated in arthropod and mammalian cells; furthermore, it was detected in a cDNA library from tick SGs and therefore may be present in tick saliva. It is important to determine whether and by what means this potential virus is transmissible and to monitor the virus as a potential emerging tick-borne zoonotic pathogen.
Descritores: Flavivirus/química
RNA Viral/isolamento & purificação
Rhipicephalus/virologia
Proteínas não Estruturais Virais/química
-Brasil
Sequência Conservada/genética
Flavivirus/classificação
Flavivirus/isolamento & purificação
Biblioteca Gênica
Interações Hidrofóbicas e Hidrofílicas
Filogenia
Reação em Cadeia da Polimerase
RNA Helicases/química
Alinhamento de Sequência/estatística & dados numéricos
Análise de Sequência de Proteína/métodos
Serina Endopeptidases/química
Extratos de Tecidos/análise
Transcriptoma/genética
Limites: Animais
Bovinos
Tipo de Publ: Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  6 / 51 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-685490
Autor: Memorias do Instituto Oswaldo Cruz; Rochael, Natalia Cadaxo; Lima, Luize Goncalves; Oliveira, Sandra Maria Pereira de; Barcinski, Marcello Andre; Saraiva, Elvira Maria; Monteiro, Robson Queiroz; Pinto-da-Silva, Lucia Helena.
Título: Leishmania amazonensis exhibits phosphatidylserine-dependent procoagulant activity, a process that is counteracted by sandfly saliva
Fonte: Mem. Inst. Oswaldo Cruz;108(6):679-685, set. 2013. graf.
Idioma: en.
Resumo: Leishmania parasites expose phosphatidylserine (PS) on their surface, a process that has been associated with regulation of host's immune responses. In this study we demonstrate that PS exposure by metacyclic promastigotes of Leishmania amazonensis favours blood coagulation. L. amazonensis accelerates in vitro coagulation of human plasma. In addition, L. amazonensis supports the assembly of the prothrombinase complex, thus promoting thrombin formation. This process was reversed by annexin V which blocks PS binding sites. During blood meal, Lutzomyia longipalpis sandfly inject saliva in the bite site, which has a series of pharmacologically active compounds that inhibit blood coagulation. Since saliva and parasites are co-injected in the host during natural transmission, we evaluated the anticoagulant properties of sandfly saliva in counteracting the procoagulant activity of L. amazonensis . Lu. longipalpis saliva reverses plasma clotting promoted by promastigotes. It also inhibits thrombin formation by the prothrombinase complex assembled either in phosphatidylcholine (PC)/PS vesicles or in L. amazonensis . Sandfly saliva inhibits factor X activation by the intrinsic tenase complex assembled on PC/PS vesicles and blocks factor Xa catalytic activity. Altogether our results show that metacyclic promastigotes of L. amazonensis are procoagulant due to PS exposure. Notably, this effect is efficiently counteracted by sandfly saliva.
Descritores: Coagulação Sanguínea/fisiologia
Leishmania/metabolismo
Fosfatidilserinas/metabolismo
Psychodidae/parasitologia
Saliva/metabolismo
-Anticoagulantes/metabolismo
Cisteína Endopeptidases
Fator V/antagonistas & inibidores
Fator X/antagonistas & inibidores
Fator Xa/antagonistas & inibidores
Insetos Vetores/parasitologia
Proteínas de Neoplasias/antagonistas & inibidores
Tempo de Tromboplastina Parcial
Fosfatidilcolinas/metabolismo
Psychodidae/metabolismo
Trombina/antagonistas & inibidores
Extratos de Tecidos/metabolismo
Limites: Animais
Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  7 / 51 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-681750
Autor: Mendoza M., Dary L; Saavedra, Stephanie.
Título: Composición química y capacidad anti-irritante de extractos de cuerpo entero de Ulomoides dermestoides (Coleoptera, Tenebrionidae) / Chemical composition and anti-irritant capacity of whole body extracts of Ulomoides dermestoides (Coleoptera, Tenebrionidae)
Fonte: Vitae (Medellín);20(1):41-48, ene.-abr. 2013. ilus, tab.
Idioma: en.
Resumo: Background: In traditional medicine of Central and South America, the tenebrionid beetle Ulomoides dermestoides is used as an a phrodisiac, for the treatment of inflammatory diseases and cancer. Recently was reported cytotoxic and genotoxic properties of non-polar extract of U. dermestoides; also anti-inflammatory and immunomodulatory activity of aqueous whole body extract of beetle was reported, it suggests the existence of components with potential pharmacology use. On the other hand, it is necessary to identify those polar and non-polar extracts of U. dermestoides with anti-irritant properties for the membranes and blood vessels, which will be used in subsequence biological test and clinical assays. Objectives: The purpose of this research was to identify the chemical composition of methanolic and hexanic extracts of U. dermestoides, and to assess their anti-irritant capacity. Methods: The extracts were obtained from adult beetles of U. dermestoides. The chemical composition of the extracts was determined by gas chromatography-mass spectrometry (GC-MS) and the anti-irritant effect of each extract was evaluated by means of a modified assay of irritation of the chorioallantoic membrane (CAM) of fertilized chicken eggs (HET-CAM); the results were expressed as irritation index (IR). Results: Six common compounds were identified in both extracts: limonene, myristic, palmitic, estearic, oleic, and linoleic fatty acids. But in the alone methanolic extract were found: 1-pentadecanol, alpha-pinene, beta-phellandrene and alpha-terpinene, whereas in the hexanic extract were found: 2-methyl-p-benzoquinone, 2,4-dihidroxy-1-ethylbenzene, 2,5-dimethyl-quinone, saturated and unsaturated hydrocarbons and alcohols. The methanolic extract of U. dermestoides showed potential anti-irritant effect in the HET-CAM test (IR = 3.09 ± 0.11), similar to that observed with Nimesulida (IR = 2.05 ± 0.14)...
Descritores: Besouros
Extratos de Tecidos
Responsável: CO56.3 - Biblioteca


  8 / 51 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Costa Rica
Texto completo
Id: lil-637653
Autor: Chinchilla-Carmona, Misael; Guerrero Bermúdez, Olga Marta; Tamayo-Castillo, Giselle; Sittenfeld Appel, Ana; Jiménez-Somarribas, Alberto; Valerio-Campos, Idalia.
Título: Concentración natural de compuestos antimaláricos en artrópodos tropicales (in vitro)
Fonte: Rev. biol. trop;56(2):473-485, jun. 2008. tab.
Idioma: es.
Resumo: Natural concentration of antimalaric components in Tropical arthropods (in vitro). Alcohol, hexane and dichlorometane extracts of 751 samples of Costa Rican arthropods were studied for the presence of antimalaric components. With Plasmodium berghei we set an in vitro model in which the effect of the extract was determined by staining of the parasites with cresil brilliant blue. Active extracts at concentration of 50 mg or less, were considered positive. Promissory extracts were found in the orders Lepidoptera (24.1%), Coleoptera (32.8%), Hemiptera (38.5%) and Polydesmida (81.3%). Since most of the Lepidoptera samples were in the immature stages, the relation with the host plant was analyzed. Cannaceae, Flacourtiaceae, Crisobalanaceae, Lauraceae, Fagaceae, Ulmaceae, Rosaceae, Asteraceae, Rubiaceae, Lauraceae and Caprifoliaceae were related with the Lepidoptera larvae, and an antimalaric effect has been reported in most of these families. In the orders Polydesmida, Opiliones and Blattodea, the extract from adults also had some important effect, probably because all of them fed on plants. Polydesmida and Opiliones have chemical substances that probably serve as defensive purposes; these chemicals could also have some antiparasitic effect. Therefore, the detection of antimalaric components in arthropod species led to the identification of plants with promissory antimalaric components. Rev. Biol. Trop. 56 (2): 473-485. Epub 2008 June 30.

Extractos alcohólicos, hexánicos y diclorometánicos de 751 muestras de artrópodos fueron estudiados por la presencia de actividad antimalárica. En este trabajo se empleó un modelo murino usando el Plasmodium berghei, modelo que es biológicamente similar a la malaria humana. El estudio fue realizado determinando el efecto del extracto sobre el parásito por la inclusión o no del colorante azul de cresil brillante. Estimando como positivos aquellos extractos cuya actividad antimalárica se mostró en concentraciones no mayores de 50 mg, se encontró que los órdenes más promisorios fueron Lepidoptera (24.1%), Polydesmida (81.3%), Blattodea (25%) y Opiliones, entre otros. Las formas inmaduras de Lepidoptera fueron las más positivas, por lo que se analizaron las plantas hospederos de donde se alimentaban dichos organismos. Las familias de estas plantas eran Malvaceae, Acanthaceae, Rutaceae, Myrtaceae, Solanaceae, Fabaceae, Urticaceae, Anacardiaceae, Rosaceae, Asteraceae, Rubiaceae, Lauraceae y Caprifoliaceae. Especies de casi todas estas familias han sido reportadas con actividad antimalárica. En el caso de los órdenes Polydesmida, Opiliones y Blattodea, cuyas formas adultas presentaron alguna actividad contra P. berghei, encontramos que todos esos grupos se alimentan también de plantas. En el caso de Opiliones sus especies son predadores de lepidópteros, coleópteros, hemípteros fitófagos y otros artrópodos, además de que producen sustancias de defensas tales como alcoholes, cetonas y quinonas, entre otros, todo lo cual podría explicar la actividad encontrada. Algunas especies del Orden Polydesmida, también secretan ciertas sustancias químicas, las cuales podrían tener un efecto antiparasitario. Así, a través de este trabajo en artrópodos hemos llegado a identificar fuentes vegetales potenciales para componentes antimaláricos.
Descritores: Antimaláricos/farmacologia
Artrópodes/química
Comportamento Alimentar/fisiologia
Malária/tratamento farmacológico
Extratos Vegetais/farmacologia
Extratos de Tecidos/farmacologia
-Antimaláricos/isolamento & purificação
Artrópodes/classificação
Artrópodes/fisiologia
Modelos Animais de Doenças
Extratos de Tecidos/isolamento & purificação
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


  9 / 51 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
Id: lil-632169
Autor: Salamanca-Gómez, Fabio.
Título: Parásitos y autoinmunidad / Parasites and Autoimmunity
Fonte: Gac. méd. Méx;140(5):565-566, sep.-oct. 2004.
Idioma: es.
Descritores: Doenças Autoimunes/terapia
Parasitos
Extratos de Tecidos/uso terapêutico
Limites: Animais
Humanos
Responsável: MX1.1 - CENIDSP - Centro de Información para Decisiones en Salud Pública


  10 / 51 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-623119
Autor: Maluf, Fernando C.; Smaletz, Oren; Herchenhorn, Daniel.
Título: Castration-resistant prostate cancer: systemic therapy in 2012
Fonte: Clinics;67(4):389-394, 2012.
Idioma: en.
Resumo: Prostate cancer is the most common non-cutaneous neoplasm in the male population worldwide. It is typically diagnosed in its early stages, and the disease exhibits a relatively indolent course in most patients. Despite the curability of localized disease with prostatectomy and radiation therapy, some patients develop metastatic disease and die. Although androgen deprivation is present in the majority of patients with metastatic prostate cancer, a state of androgen resistance eventually develops. Castration-resistant prostate cancer, defined when there is progression of disease despite low levels of testosterone, requires specialized care, and improved communication between medical and urologic oncologists has been identified as a key component in delivering effective therapy. Despite being considered a chemoresistant tumor in the past, the use of a prostate-specific antigen has paved the way for a new generation of trials for castration-resistant prostate cancer. Docetaxel is a life-prolonging chemotherapy that has been established as the standard first-line agent in two phase III clinical trials. Cabazitaxel, a novel taxane with activity in cancer models resistant to paclitaxel and docetaxel, is the only agent that has been compared to a chemotherapy control in a phase III clinical trial as a second-line therapy; it was found to prolong the overall survival of patients with castration-resistant prostate cancer previously treated with docetaxel when compared to mitoxantrone. Other agents used in this setting include abiraterone and sipuleucel-T, and novel therapies are continually being investigated in an attempt to improve the outcome for patients with castration-resistant prostate cancer.
Descritores: Antagonistas de Androgênios/uso terapêutico
Antineoplásicos/uso terapêutico
Orquiectomia
Neoplasias da Próstata/tratamento farmacológico
-Androstenóis/uso terapêutico
Ensaios Clínicos como Assunto
Progressão da Doença
Medicina Baseada em Evidências
Neoplasias da Próstata/cirurgia
Taxoides/uso terapêutico
Extratos de Tecidos/uso terapêutico
Limites: Humanos
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Revisão
Responsável: BR1.1 - BIREME



página 1 de 6 ir para página                
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde