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Pesquisa : D23.050.161 [Categoria DeCS]
Referências encontradas : 343 [refinar]
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Id: biblio-1283791
Autor: González Bonet, Ileana; Romero Elías, María Jacqueline; Morales Mejías, Erik; Valdez Moyano, Eliana; Cofré Loyola, Cecilia; Manques Maldonado, Belarmino; Rojas Rubio, Armando.
Título: Patrón EPIYA en cepas de Helicobacter pylori CagA positivas en pacientes del Hospital Regional de Talca / EPIYA pattern in Helicobacter pylori CagA positive strains in patients of the Regional Hospital of Talca
Fonte: Rev. méd. Maule;33(1):8-13, jun. 2017. tab.
Idioma: es.
Resumo: BACKGROUND: The clinical outcome of Helicobacter pylori (H. pylori) infection has been related to the presence of CagA protein. This protein is highly polymorphic and its oncogenic ability depends on the number and type of tyrosine phosphorylation sites in the EPIYAs repeat sequences (A, B, C and D). AIM: To determine the EPIYA patterns of the CagA gene in H. pylori strains and its relationship with gastrointestinal pathology in infected patients of the Regional Hospital of Talca. MATERIAL AND METHODS: The strains were isolated from gastric biopsies and characterized by bacteriological and molecular methods. Gastrointestinal pathology was characterized by histopathological analysis. For the determination of the presence of the cagA gene and the EPIYAs standards, the conventional PCR technique was used. RESULTS: 138 DNA samples from H. pylori strains were analyzed. 92.0% (127/138) of the isolates carried the cagA gene, of which 66 (52.0%) corresponded to the EPIYA-ABC pattern, 43 (33.8%) to the EPIYA-ABCC pattern and 21 16.5%) to the EPIYA-ABCCC phosphorylation pattern. 50.4% (64/127) of cagA positive strains isolated from dyspeptic patients in the Maule region have more than two C sites of phosphorylation. The number of EPIYAs C motifs was associated with the presence of more severe histopathological damage in the gastric mucosa.
Descritores: Neoplasias Gástricas/microbiologia
Neoplasias Gástricas/patologia
Helicobacter pylori/genética
Infecções por Helicobacter/microbiologia
Infecções por Helicobacter/patologia
Motivos de Aminoácidos
-Neoplasias Gástricas/epidemiologia
Proteínas de Bactérias/genética
Biópsia
DNA Bacteriano/genética
DNA Bacteriano/química
Chile/epidemiologia
Epidemiologia Descritiva
Endoscopia do Sistema Digestório
Infecções por Helicobacter/epidemiologia
Comissão de Ética
Análise de Sequência de DNA
Antígenos de Bactérias/genética
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: CL1.1 - Biblioteca Central


  2 / 343 LILACS  
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Texto completo SciELO Chile
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Id: biblio-961436
Autor: Wormwood, Tracy; Parra, Álvaro; Bresky, Gustavo; Madariaga, Juan A; Häberle, Sergio; Flores, Jacqueline; Bernal, Giuliano.
Título: Prevalencia de cepas cagA-positivo en la región de Coquimbo, determinada mediante nested-qPCR en muestras fecales / Frequency of CagA-positive Helicobacter pylori strains in 160 patients subjected to endoscopy
Fonte: Rev. méd. Chile;146(5):596-602, mayo 2018. tab, graf.
Idioma: es.
Projeto: CORFO.
Resumo: Background: Helicobacter pylori is the most significant pathogen associated with gastric diseases, including gastric cancer. Infected patients with strains that are CagA-positive generally have worse outcomes than those infected with CagA-negative strains. Patients infected with CagA-positive strains have a higher risk for developing gastric cancer. Aim: To determine the prevalence of CagA-positive H. pylori strains in fecal samples of patients from the Coquimbo Region of Chile, using a non-invasive, nested-qPCR method. Material and Methods: We evaluated 160 patients with gastrointestinal symptoms subjected to an upper gastrointestinal endoscopy. DNA was extracted from fecal samples and tested for the presence of H. pylori using nested-qPCR for the ureC gene, and subsequently compared with the results of histology-Giemsa stain from the patients' endoscopic biopsies. When H. pylori was found, the presence of CagA-positive strains was determined via nested-qPCR. Results: The histology-Giemsa stain was positive for H. pylori infection in 123 patients (76.9%), while the analysis of fecal samples detected H. pylori in 129 patients (80.6%). The sensitivity and specificity of nested-qPCR to detect the bacterium was 96.7 and 73.0% respectively. Among patients with the infection, 25% had CagA-positive strains. Conclusions: In this sample of patients, there is a low prevalence of CagA-positive H. pylori strains.
Descritores: Gastropatias/microbiologia
Proteínas de Bactérias/genética
DNA Bacteriano/genética
Helicobacter pylori/genética
Infecções por Helicobacter/diagnóstico
Fezes/microbiologia
Antígenos de Bactérias/genética
-Gastropatias/diagnóstico
Proteínas de Bactérias/isolamento & purificação
Reação em Cadeia da Polimerase
Endoscopia do Sistema Digestório
Sensibilidade e Especificidade
Antígenos de Bactérias/isolamento & purificação
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
Texto completo
Id: lil-776532
Autor: Wambier, Carlos Gustavo; Wambier, Sarah Perillo de Farias; Furini, Renata Bazan; Simão, João Carlos Lopes; Frade, Marco Andrey Cipriani; Foss, Norma Tiraboschi.
Título: Factors associated with seropositivity for APGL-Iamong household contacts of leprosy patients
Fonte: Rev. Soc. Bras. Med. Trop;49(1):83-89, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Resumo: Abstract: INTRODUCTION: Leprosy is mainly transmitted among family members who share genetic and ambient factors. The clinical form of leprosy in the index case and kinship could be risk factors for leprosy transmission. High antibody levels in household contacts (HC) in the absence of neural or skin lesions may characterize latent infection. This study aimed to evaluate the association between seropositivity for anti-phenolic glycolipid-I immunoglobulin M antibodies (APGL-I) in HC and the clinical classification of the index case and to analyze the association between APGL-I positivity with other factors such as age, kinship, and gender. METHODS: We performed a survey among 320 HC of 120 leprosy patients who were evaluated and followed-up in a leprosy outpatient clinic of a university hospital. All HC underwent complete skin examination, peripheral nerve palpation, skin sensory tests, and serologic tests for the detection and quantification of APGL-I. RESULTS: The overall seropositivity rate was 20%, and was greatly affected by kinship. APGL-I seropositivity was higher in siblings (41%), followed by parents (28%), spouses (26%), other (19%), and offspring (14%). Independent risk factors for seropositivity were being siblings (OR 3.3) and being a HC of an index case with indeterminate leprosy (OR 5.3). APGL-I seropositivity was associated with index cases with a bacillary index of 4 (88%; p<.001). Seropositivity among HC was not significantly associated with their gender and age. There was no statistical difference in the seropositivity rates of HC of index patients with paucibacillary and multibacillary leprosy. CONCLUSIONS: Strict evaluation and follow-up of HC with positive results for APGL-I is recommended. Special attention should be paid during the screening of siblings of the index cases, HC of patients with a high bacillary index, and HC of patients with indeterminate leprosy.
Descritores: Imunoglobulina M/sangue
Glicolipídeos/sangue
Hanseníase/diagnóstico
Hanseníase/transmissão
Anticorpos Antibacterianos/sangue
Antígenos de Bactérias/sangue
-Ensaio de Imunoadsorção Enzimática
Características da Família
Fatores de Risco
Busca de Comunicante
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


  4 / 343 LILACS  
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Texto completo SciELO Brasil
Lana, Francisco Carlos Felix
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Id: lil-782101
Autor: Fabri, Angélica da Conceição Oliveira Coelho; Carvalho, Ana Paula Mendes; Vieira, Nayara Figueiredo; Bueno, Isabela de Caux; Rodrigues, Rayssa Nogueira; Monteiro, Thayenne Barrozo Mota; Correa-Oliveira, Rodrigo; Duthie, Malcolm S; Lana, Francisco Carlos Félix.
Título: Integrative literature review of the reported uses of serological tests in leprosy management
Fonte: Rev. Soc. Bras. Med. Trop;49(2):158-164, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: Abstract: An integrative literature review was conducted to synthesize available publications regarding the potential use of serological tests in leprosy programs. We searched the databases Literatura Latino-Americana e do Caribe em Ciências da Saúde, Índice Bibliográfico Espanhol em Ciências da Saúde, Acervo da Biblioteca da Organização Pan-Americana da Saúde, Medical Literature Analysis and Retrieval System Online, Hanseníase, National Library of Medicine, Scopus, Ovid, Cinahl, and Web of Science for articles investigating the use of serological tests for antibodies against phenolic glycolipid-I (PGL-I), ML0405, ML2331, leprosy IDRI diagnostic-1 (LID-1), and natural disaccharide octyl-leprosy IDRI diagnostic-1 (NDO-LID). From an initial pool of 3.514 articles, 40 full-length articles fulfilled our inclusion criteria. Based on these papers, we concluded that these antibodies can be used to assist in diagnosing leprosy, detecting neuritis, monitoring therapeutic efficacy, and monitoring household contacts or at-risk populations in leprosy-endemic areas. Thus, available data suggest that serological tests could contribute substantially to leprosy management.
Descritores: Testes Sorológicos/métodos
Glicolipídeos/sangue
Hanseníase/diagnóstico
Anticorpos Antibacterianos/sangue
Mycobacterium leprae/imunologia
Antígenos de Bactérias/sangue
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


  5 / 343 LILACS  
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Araujo, Sergio
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Id: biblio-829660
Autor: Antunes, Douglas Eulálio; Ferreira, Gabriela Porto; Nicchio, Mariana Vitorino Candeiro; Araujo, Sergio; Cunha, Ana Carolina Rodrigues da; Gomes, Rafaela Resende; Costa, Adeilson Viera da; Goulart, Isabela Maria Bernardes.
Título: Number of leprosy reactions during treatment: clinical correlations and laboratory diagnosis
Fonte: Rev. Soc. Bras. Med. Trop;49(6):741-745, Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract INTRODUCTION: The occurrence of leprosy reactions, a common event during treatment, may be mostly related to the action of multidrug therapy on Mycobacterium leprae. The clinical and laboratory monitoring of patients with reactions is important, since collecting data that assists in predicting the risk of reactions may help to prevent disability. METHODS: This was a sectional study, in order to correlate clinical and laboratory diagnosis with the number of reactions during treatment. Spearman's correlation was used to verify the degree of association between the assessed variables. RESULTS: This study was conducted with 211 patients with leprosy reactions during treatment of M. leprae. The borderline tuberculoid group was the most prevalent clinical form (74/211; 35.1%) and the type one reaction showed the highest frequency (136/211; 64.5%). It was observed that 73.5% (155/211) of reactions occurred within 3 months of the initiation of multidrug therapy. The diagnostic values, including the bacterial indices (BIs) of dermal smears (r = 0.21, p < 0.05) and skin biopsies (r = 0.20; p < 0.05), showed a positive correlation with the number of reactions during treatment. CONCLUSIONS: This research showed a positive correlation between bacillary load markers and the number of leprosy reactions. This study provided scientific support to future research aiming to elucidate the influence of antigenic load on the number of leprosy reactions during treatment.
Descritores: Hansenostáticos/administração & dosagem
Hanseníase/tratamento farmacológico
Anticorpos Antibacterianos/sangue
Mycobacterium leprae/efeitos dos fármacos
Antígenos de Bactérias/sangue
-Fatores de Tempo
Estudos Transversais
Estatísticas não Paramétricas
Quimioterapia Combinada
Hansenostáticos/efeitos adversos
Hanseníase/microbiologia
Mycobacterium leprae/imunologia
Limites: Humanos
Tipo de Publ: Estudo Observacional
Responsável: BR1.1 - BIREME


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Id: biblio-1246768
Autor: Vega Lopez, Francisco.
Título: El papel de los antigenos proteicos de Mycobacterium leprae en la inmunologia de la lepra / ?
Fonte: In: Mocotela Ruiz, Ernesto; Rodriguez, Obdulia; Vega Lopez, Francisco. Topicos em dermatologia. s.l, s.n, 1995. p.44.
Idioma: es.
Descritores: Antígenos de Bactérias/imunologia
Dermatopatias/epidemiologia
Hanseníase/epidemiologia
Hanseníase/imunologia
Hanseníase/terapia
México/epidemiologia
Saúde da População Rural
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
[{"text": "BR191.1", "_a": "06157/s"}]


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Id: biblio-1246767
Autor: Rodriguez, Obdulia.
Título: Estado actual de la lepra en Mexico / ?
Fonte: In: Mocotela Ruiz, Ernesto; Rodriguez, Obdulia; Vega Lopez, Francisco. Topicos em dermatologia. s.l, s.n, 1995. p.38-41.
Idioma: es.
Descritores: Antígenos de Bactérias/imunologia
Dermatopatias/epidemiologia
Hanseníase/epidemiologia
Hanseníase/imunologia
Hanseníase/terapia
México/epidemiologia
Saúde da População Rural
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
[{"text": "BR191.1", "_a": "06157/s"}]


  8 / 343 LILACS  
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Id: biblio-1236392
Autor: Vega-Lopes, Francisco; Macotela-Ruiz, Ernesto.
Título: Importancia de los antigenos proteicos de Mycobacterium leprae. Uso potencial para el desarrollo de una vacuna contra la lepra / ?.
Fonte: s.l; s.n; 1991. 9 p.
Idioma: es.
Descritores: Antígenos de Bactérias
Hanseníase
Imunoterapia/métodos
Mycobacterium leprae
Vacinas
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
[{"text": "BR191.1", "_a": "06243/s"}]


  9 / 343 LILACS  
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Id: biblio-1236368
Autor: Polito, Darlene Silva.
Título: Estudo imunohistoquimico em biopsias de pele de doentes hansenianos multibacilares apos alta terapeutica / ?.
Fonte: Sao Paulo; s.n; 1998. 110 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Universidade de Sao Paulo. Faculdade de Medicina para obtenção do grau de Doctor.
Resumo: Doentes com hanseniase virchowiana podem apresentar surtos reacionais tipo 2 apos alta terapeutica. A presenca de antigenos do Mycobacterium leprae nos macrofagos e a sua liberacao abrupta sao apontados como importante fator no desencadeamento das reacoes. No presente trabalho e realizada a pesquisa de antigenos do Mycobacterium leprae na pele de 64 doentes com hanseniase virchowiana apos alta terapeutica, com o intuito de verificar a utilizacao pratica de metodo como indicador laboratorial do aparecimento de surto reacional tipo 2 apos alta. E empregada tecnica imunohistoquimica com anticorpos anti-bacilo de Calmette-Guerin. Os doentes sao submetidos a tres diferentes esquemas terapeuticos, por periodos variaveis de dois a 34 anos.
Descritores: Anticorpos Antibacterianos/imunologia
Antígenos de Bactérias/isolamento & purificação
Biópsia/métodos
Hanseníase/diagnóstico
Hanseníase/epidemiologia
Hanseníase/prevenção & controle
Imuno-Histoquímica/métodos
Mycobacterium leprae
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
[{"text": "BR191.1", "_a": "WC335.500", "_b": "P759e"}]


  10 / 343 LILACS  
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Id: biblio-1236367
Autor: Polito, Darlene Silva.
Título: Estudo imunohistoquimico em biopsias de pele de doentes hansenianos multibacilares apos alta terapeutica / ?.
Fonte: Sao Paulo; s.n; 1998. 110 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Universidade de Sao Paulo para obtenção do grau de Doctor.
Resumo: Doentes com hanseniase virchowiana podem apresentar surtos reacionais tipo 2 apos alta terapeutica. A presenca dos antigenos do Mycobacterium leprae nos macrofafos e a sua liberacao abrupta sao apontados como importante fator no desencadeamento das reacoes. No presente trabalho e realizada a pesquisa de antigenos do Mycobacterium leprae na pele de 64 doentes com hanseniase virchowiana apos alta terapeutica, com o intuito de verificar a utilizacao pratica do metodo como indicador laboratorial do aparecimento de surto reacional tipo 2 apos alta. E empregada tecnica imunohistoquimica com anticorpos anti-bacilo de Calmette-Guerin. Os doentes sao submetidos a tres diferentes esquemas terapeuticos, por periodos variaveis de dois a 34 anos
Descritores: Anticorpos Antibacterianos/imunologia
Antígenos de Bactérias
Biópsia/métodos
Hanseníase/diagnóstico
Hanseníase/epidemiologia
Hanseníase/imunologia
Hanseníase/prevenção & controle
Imuno-Histoquímica/métodos
Mycobacterium leprae
Responsável: BR191.1 - Biblioteca e Centro de Documentação Luiza Keffer
[{"text": "BR191.1", "_a": "335.500", "_b": "P759e"}]



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