Base de dados : LILACS
Pesquisa : D23.050.301.264.051 [Categoria DeCS]
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Fotocópia
Id: lil-284811
Autor: Rosemblatt Silber, Mario.
Título: Diferenciación linfocitaria / Linfocitary differentiation
Fonte: In: Palomo González, Iván; Ferreira Vigoroux, Arturo; Sepúlveda Carvajal, Cecilia; Rosemblatt Silber, Mario; Vergara Castillo, Ulises. Fundamentos de inmunología. Talca, Universidad de Talca, 1998. p.271-85, ilus.
Idioma: es.
Projeto: Universidad de Talca. Dirección de Investigación.
Descritores: Diferenciação Celular/imunologia
Linfócitos/citologia
-Antígenos de Diferenciação de Linfócitos B/imunologia
Antígenos de Diferenciação de Linfócitos T/imunologia
Linfócitos B/citologia
Linfócitos T/citologia
Limites: Seres Humanos
Responsável: CL1.1 - Biblioteca Central
CL1.1; QW504, F981


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Fotocópia
Id: lil-161675
Autor: Mengel, J; Campos-Neto, A.
Título: Terminal maturation of resting B cells induced by macrophage factors
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;29(2):229-37, Feb. 1996. graf, tab.
Idioma: en.
Resumo: Mouse splenic macrophages from BALB/c nude mice (purified by plastic adherence) or cloned macrophage hybridomas stimulated with jacalin (12.5 microg/ml), a D-Gal binding lectin, produce one or more B-cell stimulatory factors which cause splenic B cells from BALB/c or C3H/HeJ mice to secrete immunoglobulin in a polyclonal manner as detected by reverse protein A plaque assays. Jacalin-stimulated macrophage supernatants (JacSup) activate both normal and Percoll gradient-purified small high-density (resting) B cells. Supernatants from total or resting BALB/c spleen cells cultured for 7 days in the presence of JacSup (derived from splenic BALB/c nude mice macrophages) were assayed for immunoglobulin isotypes by ELISA. Resting B cells produce only IgG3 and IgM, whereas total B cells secrete IgG3 and IgM as well as IgG1, IgG2a, IgG2b and IgA. Resting and total B cells from BALB/c nude mice are also stimulated by macrophage supernatants to secrete immunoglobulin, thus indicating that this activity is likely to be T cell independent. Moreover, jacalin-stimulated macrophage supernatants did not induce spleen cells or purified B cells to proliferate. Fractionation of factor-rich supernatants on a Sephacryl S-200 column revealed that the factor activity is located in fractions corresponding to a molecular mass of 25-27 kDa. Taken together, these results suggest that upon the action of a macrophage factor(s) resting B cells undergo terminal differentiation without proliferation in the absence of T cells.
Descritores: Antígenos de Diferenciação de Linfócitos B/imunologia
Ativação de Macrófagos/imunologia
Lectinas/farmacologia
-Baço/citologia
CAMUNDONGOS ENDOGAMICOS CABATTOIRSH
Técnicas de Cultura de Células
Camundongos Endogâmicos BALB C
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME



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