Base de dados : LILACS
Pesquisa : D23.050.301.264.894.108 [Categoria DeCS]
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Id: lil-600998
Autor: Martins Filho, Olindo Assis.
Título: Special features of quantification of CD8+CD38+ T-cells by flow cytometry does not represent a good biomarker to monitor the reactivation of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation
Fonte: Rev. bras. hematol. hemoter;33(4):253-254, 2011.
Idioma: en.
Descritores: Linfócitos T
Antígenos CD8
Infecções por Citomegalovirus
Transplante de Células-Tronco Hematopoéticas
ADP-Ribosil Ciclase 1
Aloenxertos
Citometria de Fluxo
Tipo de Publ: Comentário
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM


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Id: biblio-999996
Autor: Guerra Cevallos, Verónica; Núñez-González, Solange; Ochoa, Estefanía; Félix, Camilo; Simancas Racines, Daniel.
Título: Imnuno-Oncología: Recuento Histórico y Fundamentos Básicos / Imnuno-Oncology: Historical Recount and Basic Fundamentals
Fonte: Oncol. (Guayaquil) = Oncol. (Guayaquil);28(1):62-72, 30 de Abril 2018.
Idioma: es.
Resumo: El sistema inmune cumple un rol fundamental en la defensa contra microorganismos y células anómalas. Históricamente, el concepto de vigilancia inmunológica se fundamenta en el control de múltiples funciones incluyendo la regulación de células cancerígenas a través de diversos mecanismos, en los cuales están involucrados: células, moléculas y tejidos del sistema inmune. El objetivo de analizar la respuesta inmune frente al cáncer, es entender los mecanismos de presentación del antígeno y los mecanismos desencadenados por el sistema adaptativo e innato que participan en la destrucción del tumor a expensas de un proceso inflamatorio agudo que podría llevar al control o destrucción del cáncer. La propuesta de esta revisión es resumir y esquematizar los aspectos cardinales de los diferentes procesos inmunológicos que participan en la fisiopatología de las enfermedades malignas, así como los mecanismos que emplea el sistema inmune para la defensa del cáncer.

The Inmune System plays an essential role in the defense of the organism against microorganisms and alters cells. Historically, the concept of immune surveillance its based in the control of multiple functions including the regulation of cancer cells through diverse mechanisms such as cells, molecules and tissue from the immune system. Therefore, it is important to understand the mechanisms of antigen presentation and other mechanisms of the innate and adaptive system which participate in the defense of the organism against the tumor. This process is enhancing by an inflammatory acute process that could lead to the control or de destruction of the tumor. The purpose of this review is to develop the cardinal aspects of the immunologic process that take part in the defense against malignant diseases, and also to explain its mechanisms.
Descritores: Sistema Imunitário
Imunidade
Formação de Anticorpos
-Antígenos CD4
Antígenos CD8
Antígenos
Limites: Humanos
Tipo de Publ: Revisão
Responsável: EC104.1 - Biblioteca


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Id: lil-752085
Autor: Graça, Carla Renata; Kouyoumdjian, João Aris.
Título: Expressão de antígenos MHC classe I e de células CD4 e CD8 na polimiosite e dermatomiosite / MHC class I antigens, CD4 and CD8 expressions in polymyositis and dermatomyositis
Fonte: Rev. bras. reumatol;55(3):203-208, May-Jun/2015. tab, graf.
Idioma: pt.
Resumo: Objetivo: Analisar as frequências de expressão dos antígenos de complexo principal de histocompatibilidade classe I (MHC-I) e células CD4 e CD8 no músculo esquelético na polimiosite (PM) e dermatomiosite (DM). Métodos: Estudo retrospectivo de 34 casos de PM, oito casos de DM e 29 controles com miopatias não inflamatórias. Resultados: Os antígenos MHC-I expressaram-se no sarcolema e/ou sarcoplasma em 79,4% dos casos de PM, 62,5% dos casos de DM e 27,6% dos controles (a expressão de CD4 foi observada em 76,5%, 75% e 13,8%, respectivamente). Quando os antígenos de MHC-I foram coexpressados com CD4, houve elevada suspeita de PM/DM (principalmente PM). Em 14,3% dos casos de PM/DM, observou-se a expressão isolada dos antígenos MHC-I, sem células inflamatórias. Conclusão: A expressão dos antígenos MHC-I e a positividade do CD4 podem aumentar a suspeita diagnóstica de PM/DM. Não foi observado infiltrado celular em 14,3% dos casos. .

Objective: To analyze the frequencies of the expression of major histocompatibility complex class I (MHC-I) antigens, and CD4 and CD8 cells in skeletal muscle in polymyositis (PM) and dermatomyositis (DM). Methods: This was a retrospective study of 34 PM cases, 8 DM cases, and 29 control patients with non-inflammatory myopathies. Results: MHC-I antigens were expressed in the sarcolemma and/or sarcoplasm in 79.4% of PM cases, 62.5% of DM cases, and 27.6% of controls (CD4 expression was observed in 76.5%, 75%, and 13.8%, respectively). There was a high suspicion of PM/DM (mainly PM) in participants in whom MHC-I antigens and CD4 were co-expressed. In 14.3% of PM/DM cases, we observed MHC-I antigens expression alone, without inflammatory cells. Conclusion: MHC-I antigens expression and CD4 positivity might add to strong diagnostic suspicion of PM/DM. No cellular infiltration was observed in approximately 14.3% of such cases. .
Descritores: Antígenos CD4/biossíntese
Antígenos CD8/biossíntese
Dermatomiosite/metabolismo
Antígenos de Histocompatibilidade Classe I/biossíntese
Polimiosite/metabolismo
-Antígenos CD4/análise
Antígenos CD8/análise
Dermatomiosite/imunologia
Antígenos de Histocompatibilidade Classe I/análise
Músculo Esquelético/química
Polimiosite/imunologia
Estudos Retrospectivos
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-233708
Autor: Didoli, G; Revelli, S; Davila, H; Ferro, M. E; Romero-Piffiguer, M; Bottasso, O.
Título: Administration of interferon-gama to pregnant rats reverses the depressed adjuvant-induced arthritis of their chronically Trypanosoma cruzi-infected offspring
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;32(6):753-60, Jun. 1999. ilus.
Idioma: en.
Resumo: We demonstrated that administration of interferon gamma (IFN-gama) to the inbred "l" strain of pregnant rats conferred partial resistance on their offspring to challenge with Trypanosoma cruzi. We now examine if this intervention also modifies the reportedly immunodepressed cellular responses which occur during chronic infection. Offspring were born to mothers undergoing one of the following procedures during gestation: subcutaneous injections of recombinant rat IFN-gama, 50,000 IU/rat, five times/week for 3 weeks, which was started on the day of mating (IFN-Mo); infection with 106 trypomastigotes of T. cruzi at 7, 14, and 21 days after mating plus IFN-gama treatment as given to the former group (TcIFN-Mo); the same protocol except that physiological saline was injected instead of IFN-gama (Tc-Mo); injection of physiological saline only (control-Mo). All offspring groups (N = 8-10/group) were infected at weaning and were assessed 90 days later for their adjuvant-induced arthritic response or levels of major T cell subsets in spleen and lymph nodes. TcIFN-Mo and IFN-Mo offspring showed a reestablished arthritic response, which remained within the range seen in controls. Immunolabeling studies on parallel groups of 90-day-infected offspring showed that the inverse CD4/CD8 cell ratio that is usually seen in lymphoid organs from these chronically infected rats (median 0.61) appeared to have recovered in the TcIFN-Mo and IFN-Mo groups (median 1.66 and 1.78, respectively) and was not different from uninfected controls (1.96). These studies indicate that early stimulation with IFN-gama is able to reverse the immunosuppressive state that is usually present during the chronic period of the experimental infection.
Descritores: Artrite Experimental/imunologia
Doença de Chagas/imunologia
Interferon gama/farmacologia
-Antígenos CD8
Antígenos de Diferenciação de Linfócitos T
Doença Crônica
Adjuvante de Freund
Linfonodos/citologia
Ratos Endogâmicos
Baço/citologia
Linfócitos T
Limites: Animais
Masculino
Feminino
Gravidez
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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