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Lampe, Elisabeth
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Id: biblio-841815
Autor: Almeida, Ricardo Wagner de; Mello, Francisco Campello do Amaral; Menegoy, Isabelle Vasconcelos; Santo, Márcia Paschoal do Espírito; Ginuíno, Cléber Ferreira; Sousa, Paulo Sérgio Fonseca de; Villar, Livia Melo; Lampe, Elisabeth; Lewis-Ximenez, Lia Laura.
Título: Detection and molecular characterisation of a diagnosis escape variant associated with occult hepatitis B virus in Brazil
Fonte: Mem. Inst. Oswaldo Cruz;112(7):485-491, July 2017. tab, graf.
Idioma: en.
Resumo: BACKGROUND Many studies have identified mutations in the hepatitis B surface antigen (HBsAg) as important factors limiting the ability of commercial serological assays to detect this viral antigen. However, an association between mutations in the HBsAg gene and the occurrence of occult HBV infection (OBI) in patients has not been established. OBJECTIVES To detect hepatitis B virus (HBV) DNA in patients with anti-HBc as a unique serological marker, a previously published, cost-effective TaqMan-based real-time polymerase chain reaction (PCR) test with minor groove binding probes was adapted for use in this study. The current study also aimed to investigate HBsAg mutations and genotypes of HBV in OBI at the Viral Hepatitis Ambulatory Clinic in Rio de Janeiro to determine any possible association. METHODS Intra-assay and inter-assay reproducibility were determined, and the mean coefficient of variation values obtained were 2.07 and 3.5, respectively. Probit analysis indicated that the 95% detection level was 25 IU/mL. The prevalence of OBI was investigated in 35 serum samples with an ‘anti-HBc alone’ profile from individuals who attended our clinic between 2011 and 2013. FINDINGS HBV DNA was detected in only one sample, resulting in an OBI rate of 2.9%. Nucleotide sequencing of the pre-S/S region was performed to genotype and analyse mutations within the HBsAg gene of this HBV DNA. The HBV in the OBI case was classified as sub-genotype A1, and a sequence analysis of the small S gene revealed 12 mutations in the major hydrophilic region compared to the consensus A1 sequence. Most of these mutations occurred in amino acid residues that have been reported as clinically relevant because they have been implicated in vaccine escape and/or inability to detect HBsAg by commercial serological assays. MAIN CONCLUSIONS Our study suggests the importance of specific HBsAg mutations, different from those in D, B, and C genotypes, in sub-genotype A1 HBV associated with OBI.
Descritores: DNA Viral/isolamento & purificação
DNA Viral/genética
Hepatite B/genética
Hepatite B/virologia
Antígenos de Superfície da Hepatite B/genética
-Sensibilidade e Especificidade
Reação em Cadeia da Polimerase em Tempo Real
Responsável: BR1.1 - BIREME


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Simón, Daniel
Lunge, Vagner Ricardo
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Id: biblio-894870
Autor: Pereira, Vagner Reinaldo Zingalli Bueno; Wolf, Jonas Michel; Luz, Camila Albani da Silva; Stumm, Gláucia Zuleide; Boeira, Thais da Rocha; Galvan, Josiane; Simon, Daniel; Lunge, Vagner Ricardo.
Título: Risk factors for hepatitis B transmission in South Brazil
Fonte: Mem. Inst. Oswaldo Cruz;112(8):544-550, Aug. 2017. tab.
Idioma: en.
Resumo: BACKGROUND Hepatitis B virus (HBV) infection is a major public health problem in Brazil. Several risk factors are involved in HBV infection and their identification by a rational and essential approach is required to prevent the transmission of this infection in Brazil. OBJECTIVES To evaluate risk factors associated with HBV infection in South Brazil. METHODS A total of 260 patients with HBV and 260 controls from Caxias do Sul (state of Rio Grande do Sul, Brazil) participated in this study. All participants were given a standard questionnaire to yield the sociodemographic information and to identify HBV risk factors. HBV infection was detected by HBsAg test in all participants. FINDINGS HBV infection in these cases was strongly associated with history of a family member HBV-infected, mainly mother [odds ratio (OR) = 4.86; 95% confidence intervals (CI): 1.69-13.91], father (OR = 5.28; 95% CI: 1.58-17.71), and/or siblings (OR = 22.16; 95% CI: 9.39-52.25); sharing personal objects (OR = 1.40; 95% CI: 1.37-2.38); and having history of blood transfusion (OR = 2.05; 95% CI: 1.10-2.84). CONCLUSIONS HBV infection was strongly associated with having a family member infected with hepatitis B, sharing personal objects, and having history of blood transfusion.
Descritores: Vírus da Hepatite B/imunologia
Hepatite B Crônica/diagnóstico
Hepatite B Crônica/transmissão
Hepatite B Crônica/epidemiologia
Anticorpos Anti-Hepatite B/sangue
Antígenos de Superfície da Hepatite B/sangue
-Fatores Socioeconômicos
Brasil/epidemiologia
Estudos de Casos e Controles
Saúde da Família
Reação Transfusional
Limites: Adolescente
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-913758
Autor: Klein, Gisleyne; Botelho, Tatiani Karini Rensi; Cordova, Caio Mauricio Mendes de; Livramento, Andréa do.
Título: High prevalence of HBV carriers among waste collectors in the largest landfill in Latin America
Fonte: Rev. patol. trop;47(1):5-10, març. 2018. tab.
Idioma: en.
Resumo: Hepatitis B virus (HBV) is a serious public health problem. Some professions are at an increased risk for HBV infection, such as recyclable waste collectors. In this study, the aim was to evaluate the prevalence of HBV carriers and vaccination coverage among waste collectors in the largest landfill in the Rio de Janeiro metropolitan area, as well as to determine the association between risk factors and HBV infection in the studied population. In this study 73 participants answered a questionnaire on their socio-demographic variables and occupational exposure to waste. All of the subjects in the study were tested for HBsAg and their vaccination cards were evaluated in order to assess their HBV vaccination status. The vaccination coverage among the individuals who had a vaccination card was 57.4%. The overall prevalence of HBsAg was 12.3%. The prevalence of HBsAg was significantly higher among men (p = 0.002). However, no statistical differences were found in the prevalence of HBsAg between individuals with a history of occupational accidents involving sharp edges and non-injured individuals (p = 0.267). The results of this study demonstrate the need to strengthen prevention measures and increase HBV vaccination among waste collectors.
Descritores: Hepatite B
-Coletores
Vírus da Hepatite B
Antígenos de Superfície da Hepatite B
Responsável: BR816.9


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Id: biblio-845857
Autor: Toscano, Ana Luiza de Castro Conde; Corrêa, Maria Cássia Mendes.
Título: Evolution of hepatitis B serological markers in HIV coinfected patients: a case study
Fonte: Rev. saúde pública = J. public health;51:24, 2017. tab.
Idioma: en.
Resumo: ABSTRACT OBJECTIVE To describe the evolution of serological markers among HIV and hepatitis B coinfected patients, with emphasis on evaluating the reactivation or seroreversion of these markers. METHODS The study population consisted of patients met in an AIDS Outpatient Clinic in São Paulo State, Brazil. We included in the analysis all HIV-infected and who underwent at least two positive hepatitis B surface antigen serological testing during clinical follow up, with tests taken six months apart. Patients were tested with commercial kits available for hepatitis B serological markers by microparticle enzyme immunoassay. Clinical variables were collected: age, sex, CD4+ T-cell count, HIV viral load, alanine aminotransferase level, exposure to antiretroviral drugs including lamivudine and/or tenofovir. RESULTS Among 2,242 HIV positive patients, we identified 105 (4.7%) patients with chronic hepatitis B. Follow up time for these patients varied from six months to 20.5 years. All patients underwent antiretroviral therapy during follow-up. Among patients with chronic hepatitis B, 58% were hepatitis B “e” antigen positive at the first assessment. Clearance of hepatitis B surface antigen occurred in 15% (16/105) of patients with chronic hepatitis B, and 50% (8/16) of these patients presented subsequent reactivation or seroreversion of hepatitis B surface antigen. Among hepatitis B “e” antigen positive patients, 57% (35/61) presented clearance of this serologic marker. During clinical follow up, 28.5% (10/35) of those who initially cleared hepatitis B “e” antigen presented seroreversion or reactivation of this marker. CONCLUSIONS Among HIV coinfected patients under antiretroviral therapy, changes of HBV serological markers were frequently observed. These results suggest that frequent monitoring of these serum markers should be recommended.
Descritores: Antígenos E da Hepatite B/sangue
Antígenos de Superfície da Hepatite B/sangue
Vírus da Hepatite B/imunologia
Hepatite B Crônica/imunologia
Infecções por HIV/complicações
-Biomarcadores/sangue
Linfócitos T CD4-Positivos
Coinfecção
Antígenos E da Hepatite B/imunologia
Antígenos de Superfície da Hepatite B/imunologia
Hepatite B Crônica/complicações
Soroconversão
Carga Viral
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-778998
Autor: Pereira, Camila V; Tovo, Cristiane Valle; Grossmann, Thiago K; Mirenda, Henrique; Dal-Pupo, Bruna B; Almeida, Paulo RL de; Mattos, Angelo A de.
Título: Efficacy of entecavir and tenofovir in chronic hepatitis B under treatment in the public health system in southern Brazil
Fonte: Mem. Inst. Oswaldo Cruz;111(4):252-257, Apr. 2016. tab.
Idioma: en.
Resumo: There are about 350 million hepatitis B virus (HBV) carriers worldwide and chronic HBV is considered a major public health problem. The objective of the present study was to assess the effectiveness of the nucleos(t)ide analogues tenofovir (TDF) and entecavir (ETV) in the treatment of chronic HBV. A cross-sectional study was carried out from March-December 2013, including all patients with chronic HBV, over 18 years of age, undergoing therapy through the public health system in southern Brazil. Only the data relating to the first treatments performed with TDF or ETV were considered. Retreatment, co-infection, transplanted or immunosuppressed patients were excluded. Six hundred and forty patients were evaluated, of which 336 (52.5%) received TDF and 165 (25.8%) ETV. The other 139 (21.7%) used various combinations of nucleos(t)ide analogues and were excluded. The negativation of viral load was observed in 87.3% and 78.8% and the negativation of hepatitis B e antigen was achieved in 79% and 72% of those treated with ETV or TDF, respectively. Negativation of hepatitis B surface antigen was not observed. There was no occurrence of adverse effects. This is a real-life study demonstrating that long-term treatment with ETV and TDF is both safe and effective.
Descritores: Antivirais/uso terapêutico
Guanina/análogos & derivados
Hepatite B Crônica/tratamento farmacológico
Tenofovir/uso terapêutico
-Estudos Transversais
DNA Viral
Guanina/uso terapêutico
Antígenos E da Hepatite B/imunologia
Antígenos de Superfície da Hepatite B/imunologia
Vírus da Hepatite B/imunologia
Saúde Pública
Resultado do Tratamento
Carga Viral
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-776471
Autor: Ding, Feng; Miao, Xi-Li; Li, Yan-Xia; Dai, Jin-Fen; Yu, Hong-Gang.
Título: Mutations in the S gene and in the overlapping reverse transcriptase region in chronic hepatitis B Chinese patients with coexistence of HBsAg and anti-HBs
Fonte: Braz. j. infect. dis;20(1):1-7, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: Abstract Background The mechanism underlying the coexistence of hepatitis B surface antigen and antibodies to HBsAg in chronic hepatitis B patients remains unknown. Aims This research aimed to determine the clinical and virological features of the rare pattern. Methods A total of 32 chronic hepatitis B patients infected by HBV genotype C were included: 15 carrying both HBsAg and anti-HBs (group I) and 17 solely positive for HBsAg (group II). S gene and reverse transcriptase region sequences were amplified, sequenced and compared with the reference sequences. Results The amino acid variability within major hydrophilic region, especially the “a” determinant region, and within reverse transcriptase for regions overlapping the major hydrophilic region in group I is significantly higher than those in group II. Mutation sI126S/T within the “a” determinant was the most frequent change, and only patients from group I had the sQ129R, sG130N, sF134I, sG145R amino acid changes, which are known to alter immunogenicity. Conclusions In chronic patients, the concurrent HBsAg/anti-HBs serological profile is associated with an increased aa variability in several key areas of HBV genome. Additional research on these genetic mutants are needed to clarify their biological significance for viral persistence.
Descritores: Anticorpos Anti-Hepatite B/sangue
Antígenos de Superfície da Hepatite B/sangue
Vírus da Hepatite B/genética
Hepatite B Crônica/genética
Hepatite B Crônica/imunologia
DNA Polimerase Dirigida por RNA/genética
Proteínas do Envelope Viral/genética
-China
DNA Viral
Genótipo
Vírus da Hepatite B/imunologia
Mutação
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Limites: Adulto
Feminino
Seres Humanos
Masculino
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-772787
Autor: Cruz, Helena Medina.
Título: Avaliação do desempenho de testes rápidos na detecção de marcadores do vírus da hepatite B / Evaluation of the performance of rapid tests for detection of hepatitis B virus markers.
Fonte: Rio de Janeiro; s.n; 2014. xvii,100 p. ilus, graf, tab, mapas.
Idioma: pt.
Tese: Apresentada a Instituto Oswaldo Cruz para obtenção do grau de Mestre.
Resumo: O uso de testes rápidos (TR) para detecção de marcadores de infecção pelo vírus da hepatite B (HBV) pode ser uma ferramenta para aumentar o acesso ao diagnóstico em áreas de difícil acesso. O objetivo deste estudo foi avaliar o desempenho de TRs na detecção de marcadores do HBV para fins de diagnóstico e estudos epidemiológicos. Um painel de referência com amostras de soro de pacientes com infecção pelo HBV e indivíduos saudáveis foi confeccionado para avaliação dos testes rápidos na detecção do HBsAg. Após, amostras de soro, sangue total e saliva foram obtidas de indivíduos de três grupos: i) alta endemicidade, ii) Baixa prevalência, e iii) alta vulnerabilidade para aquisição do HBV, e foram empregadas para avaliação dos TRs de detecção de HBsAg, anti-HBs e anti-HBe. Cinco TR foram avaliados: Vikia HBsAg® (Biomérieux, França), HBsAg teste rápido (Doles, Brasil), e do fabricante Wama (Brasil), os testes: Imuno- Rápido HBsAg®, Imuno-rápido anti-HBsAg® e Imuno-rápido anti-HBeAg®. Amostras de soro foram avaliadas em todos os TR, saliva foi avaliada nos TR para a detecção do HBsAg e sangue total somente no TR Vikia HBsAg®. Os resultados dos TR foram comparados com os obtidos em testes imunoenzimáticos comerciais (EIE) para detecção de HBsAg e anti-HBs e teste de eletroquimioluminescencia (ECLIA) para detecção de anti-HBe. Os TR para detecção de HBsAg tiveram sua repetitividade e reprodutibilidade em amostras de soro e saliva avaliadas, assim como a determinação de reação cruzada a outras infecções. O Vikia HBsAg® apresentou melhor concordância, utilizando amostras de soro no painel de referencia (98,68 por cento) e no total dos grupos de diferentes perfis (96,08 por cento), sendo melhor no grupo i (95,81 por cento). Os diferentes TR para detecção do HBsAg utilizando amostras de soro apresentaram concordância acima de 93 por cento no painel de referência e 87 por cento nos grupos de diferentes perfis...

Nos dois cenários, houve aumento da sensibilidade dos TRs para detecção do HBsAg de acordo com a presença do HBV DNA. O TR Vikia HBsAg® apresentou concordância em amostras de sangue total de 72,72 por cento, exceto no grupo ii, onde não foi possível detectar amostras HBsAg verdadeiro positivas. Os TR para HBsAg apresentaram baixos valores de concordância em amostras de saliva (45,65 por cento), somente o Imuno-rápido HBsAg® conseguiu detectar um maior número de amostras verdadeiro positivos (n=34). Os TR para detecção de anti-HBs e anti-HBe apresentaram concordâncias iguais a 54,73 por cento e 56,89 por cento, respectivamente. O Imuno-rápido anti-HBs® apresentou melhores valores de sensibilidade em amostras com altos títulos de anti-HBs e naquelas obtidas de indivíduos com anti-HBc e anti-HBs reagente. Os TR para HBsAg apresentaram excelente repetitividade e reprodutibilidade (concordância igual à 100 por cento) em amostras de soro e saliva. Não foram observados resultados HBsAg falso positivo ou negativo em amostras reativas para Dengue, porém resultados discordantes foram observados em todos os TRs avaliados em amostras com sorologia reativa para HCV, HIV e Treponema pallidum. Conclui-se que, TR para detecção do HBsAg podem ser empregados no diagnóstico da infecção em amostras de soro, enquanto os TR para detecção de anti-HBe e anti-HBs apresentam baixo desempenho para uso diagnóstico. Palavras-chave: Teste rápido, HBsAg, anti-HBs, anti-Hbe...
Descritores: Antígenos de Superfície da Hepatite B
Hepatite B/diagnóstico
Hepatite B/patologia
Vírus da Hepatite B/crescimento & desenvolvimento
-Biomarcadores
Limites: Seres Humanos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


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Id: lil-771923
Autor: BHATE, Prasad; SARAF, Naimish; PARIKH, Pathik; INGLE, Meghraj; PHADKE, Aniruddha; SAWANT, Prabha.
Título: CROSS SECTIONAL STUDY OF PREVALENCE AND RISK FACTORS OF HEPATITIS B AND HEPATITIS C INFECTION IN A RURAL VILLAGE OF INDIA
Fonte: Arq. gastroenterol;52(4):321-324, Oct.-Dec. 2015. tab.
Idioma: en.
Resumo: Background - Hepatitis B virus and hepatitis C virus are among the principal causes of severe liver disease. There is limited data of epidemiology of Hepatitis B in community, more so in rural population. Objective - To find the prevalence of hepatitis B and C infection in community and study the risk factors for their transmission. Methods - This was a community based cross sectional study. A total of 1833 randomly selected subjects from a rural area were interviewed for risk factors for transmission and tested for markers of hepatitis B and hepatitis C infection. All the positive card tests were confirmed by ELISA. Results - Out of 2400 subjects, rate for participation was 76.38%. None of the subjects was positive for anti hepatitis C virus antibody. Point prevalence for HBsAg positivity was 0.92. Being healthcare worker and having tattoo were significantly associated with HBsAg positive results. Nose and ear piercing was reported by almost. History of blood or blood product transfusion, I/V drug abuse, multiple sexual partners, unsafe Injections, hemodialysis and any h/o surgery was not associated with HBsAg positivity. Conclusion - Health care workers are at high risk for transmission of hepatitis B. Educating common people regarding mode of transmission of Hepatitis B and C will help to reduce their transmission.

Contexto - O vírus da hepatite B e o vírus da hepatite C estão entre as principais causas de doença grave do fígado. Há dados limitados de epidemiologia da hepatite B na comunidade observada, mais ainda na população rural. Objetivo - Encontrar a prevalência de infecção de hepatite B e C em uma comunidade da India e pesquisar os fatores de risco para sua transmissão. Métodos - Feito estudo de corte transversal em uma comunidade. Um total de 1833 sujeitos selecionados aleatoriamente em uma área rural foram entrevistados para fatores de risco para transmissão e testados para marcadores da infecção por hepatite B e C. Todos os testes positivos de cartão foram confirmados por ELISA. Resultados - Dos 2400 pacientes objetivados houve uma taxa de participação de 76.38%. Nenhum dos indivíduos foi positivo para anticorpo anti vírus da hepatite C. A prevalência pontual para a positividade do HBsAg foi de 0,92. Ser trabalhador na área de saúde e ter tatuagem foram significativamente associados com resultados positivos de HBsAg. "Piercing" em nariz e orelha foram relatados por quase todos. História de transfusão de sangue ou uso de hemoderivados, abuso de drogas via endovenosa, múltiplos parceiros sexuais, injeções inseguras, hemodiálise e história prévia de cirurgia, não estiveram associadas à positividade do HBsAg. Conclusão - Os trabalhadores de saúde estão em alto risco para a transmissão de hepatite B. Educar pessoas comuns sobre o modo de transmissão de hepatite B e C ajudará a reduzir a sua transmissão.
Descritores: Hepacivirus/imunologia
Vírus da Hepatite B/imunologia
Hepatite B/epidemiologia
Hepatite C/epidemiologia
-Estudos Transversais
Ensaio de Imunoadsorção Enzimática
Anticorpos Anti-Hepatite B/sangue
Antígenos de Superfície da Hepatite B/sangue
Hepatite B/diagnóstico
Anticorpos Anti-Hepatite C/sangue
Hepatite C/diagnóstico
Índia/epidemiologia
Prevalência
Fatores de Risco
População Rural
Estudos Soroepidemiológicos
Limites: Adolescente
Adulto
Criança
Pré-Escolar
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Martinelli, Ana de Lourdes Candolo
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Id: lil-767824
Autor: Melo, Laura Valdiane Luz; Silva, Marcondes Alves Barbosa da; Perdoná, Gleici da Silva Castro; Nascimento, Margarida Maria Passeri; Secaf, Marie; Monteiro, Rosane Aparecida; Martinelli, Ana de Lourdes Candolo; Passos, Afonso Dinis Costa.
Título: Epidemiological study of hepatitis B and C in a municipality with rural characteristics: Cássia dos Coqueiros, State of São Paulo, Brazil
Fonte: Rev. Soc. Bras. Med. Trop;48(6):674-681, Nov.-Dec. 2015. tab, graf.
Idioma: en.
Resumo: Abstract: INTRODUCTION: Hepatitis B and C viral infections remain an important cause of global morbidity and mortality. Studies have been conducted in population groups of large cities, leaving gaps in the knowledge regarding the situation in small municipalities. We aimed to measure the prevalence of hepatitis B and C markers and presence of infection-associated factors. METHODS: All inhabitants of Cássia dos Coqueiros aged ≥18 years who agreed to participate in the research were included. We collected blood as well as information via a questionnaire between March 2011 and December 2013. Univariate and multivariate analyses were conducted. RESULTS: Among the 1,001 participants, 41 (4.1%) participants had a serological profile of hepatitis B viral exposure, and only one (0.1%) participant was considered a virus carrier. The frequency of isolated antibody to hepatitis B virus surface antigen (anti-HBs) markers was 17.8% for the overall population. In the multivariate analysis, hepatitis B virus (HBV) infection was associated with age, birth outside the State of São Paulo, history of hepatitis, ≥2 sexual partners in the last 6 months, and tattoos. Four (0.4%) participants had a serological profile of hepatitis C viral exposure. However, after confirmation using viral ribonucleic acid (RNA) evaluation, only one (0.1%) individual remained positive. CONCLUSIONS: The positivity rates for hepatitis B and C were low, despite greater sexual freedom and the recent emergence of illicit drugs, as observed by the health personnel working in Cássia dos Coqueiros.
Descritores: Hepatite B/epidemiologia
Hepatite C/epidemiologia
-Brasil/epidemiologia
Métodos Epidemiológicos
Anticorpos Anti-Hepatite B/sangue
Antígenos do Núcleo do Vírus da Hepatite B/sangue
Antígenos de Superfície da Hepatite B/sangue
Vírus da Hepatite B/imunologia
Anticorpos Anti-Hepatite C/sangue
População Rural
Fatores Socioeconômicos
População Urbana
Limites: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Seres Humanos
Masculino
Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Bordin, José Orlando
Silva, Antonio Eduardo Benedito
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Id: lil-763325
Autor: Narciso-Schiavon, Janaína Luz; Schiavon, Leonardo de Lucca; Carvalho-Filho, Roberto José de; Emori, Christine Takemi; Maryia, Fernando Akio; Bordin, José Orlando; Silva, Antonio Eduardo Benedito; Ferraz, Maria Lucia Gomes.
Título: Clinical and epidemiological profile of female blood donors with positive serology for viral hepatitis B
Fonte: Rev. Soc. Bras. Med. Trop;48(5):524-531, Sept.-Oct. 2015. tab, graf.
Idioma: en.
Resumo: ABSTRACTINTRODUCTION:Since women are frequently the minority among blood donors worldwide, studies evaluating this population usually reflect male features. We assessed the features of female blood donors with positive serology for HBV and compared them with those of men.METHODS The study comprised consecutive blood donors referred to a specialized liver disease center to be evaluated due to HBsAg- and/or anti-HBc-positive tests.RESULTS: The study encompassed 1,273 individuals, 219 (17.2%) of whom were referred due to positive HBsAg test and 1,054 (82.8%) due to reactive anti-HBc test. Subjects' mean age was 36.8±10.9 years, and 28.7% were women. Female blood donors referred for positive HBsAg screening tests demonstrated higher prevalence of healthcare workers (9.3% vs 2.5%) and lower prevalence of sexual risk behaviors (15.1% vs 41.1%) and alcohol abuse (1.9% vs 19.8%) compared to men. Women had lower ALT (0.6 vs 0.8×ULN), AST (0.6 vs 0.8×ULN), direct bilirubin (0.2 vs 0.3mg/dL), and alkaline phosphatase (0.5 vs 0.6×ULN) levels and higher platelet count (223,380±50,293 vs 195,020±53,060/mm3). Women also had a higher prevalence of false-positive results (29.6% vs 17.0%). No differences were observed with respect to liver biopsies. Female blood donors referenced for reactive anti-HBc screening tests presented similar clinical, epidemiological, and biochemical characteristics to those reported for positive HBsAg screening tests and similarly had a higher prevalence of false-reactive results.CONCLUSIONS: Compared to men, female blood donors with positive HBsAg and/or anti-HBc screening tests demonstrated higher prevalence of professional risk and false-positive results and reduced alteration of liver chemistry.
Descritores: Doadores de Sangue/estatística & dados numéricos
Hepatite B/epidemiologia
-Brasil/epidemiologia
Métodos Epidemiológicos
Reações Falso-Positivas
Anticorpos Anti-Hepatite B/sangue
Antígenos do Núcleo do Vírus da Hepatite B/sangue
Antígenos de Superfície da Hepatite B/sangue
Vírus da Hepatite B/imunologia
Hepatite B/diagnóstico
Imunoglobulina M/sangue
Fatores Sexuais
Limites: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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