Base de dados : LILACS
Pesquisa : D23.125.320 [Categoria DeCS]
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Fotocópia
Id: lil-462811
Autor: Figuera, Lourdes; Kalale, Heidi; Marchán, Edgar.
Título: Relación entre la helmintiasis intestinal y el estado nutricional-hematológico en niños de una escuela rural en el estado Sucre Venezuela / Relantionship between intestinal helminthiasis and Nutritional-haematologic status on rural schoolchildren at Sucre state Venezuela
Fonte: Kasmera;34(1):14-24, ene.-jun. 2006. tab.
Idioma: es.
Resumo: Se realizó una evaluación parasitológica, nutricional y hematológica en 103 niños de ambos sexos, entre 4-12 años de una escuela rural en Santa Fe, estado Sucre, Venezuela, durante el período enero-marzo 2003. Las muestras de heces se analizaron mediante un examen al fresco, Willis-Malloy y Kato-Katz cuantitativo. El estado nutricional se determinó utilizando la combinación de los índices antropométricos. Los parámetros hematológicos fueron evaluados por los métodos clásicos, y el grado de eosinofilia se expresó en valores absolutos de eosinófilos. 93,2 por ciento de los escolares estaban parasitados, presentando elevado poliparasitismo (83,3 por ciento). La prevalencia de helmintos intestinales fue de 82, por ciento, destacando la asociación de Trichuris trichiura y Ascaris lumbricoides (69,4 por ciento) y predominando una intensidad de infestación leve. De los individuos con desnutrición, el 91,2 por ciento (31/34) tenían helmintiasis. En 97,6 por ciento de los escolares infestados por helmintos se encontró eosinofilia (p<0,001). Del 23,3 por ciento de los niños con anemia, 83,3 por ciento (20/24) presentaron helmintiasis. El 88,8 por ciento de los niños con helmintiasis intestinal pertenecían al estrato socioeconómico V. Estos hallazgos sugieren que la población escolar evaluada habita en una zona hiperendémica de helmintos, consistente con el estrato socioeconómico encontrado. Adicionalmente, se estableció que la eosinofilia en estos escolares es un factor asociado a la helmintiasis intestinal
Descritores: Ascaris lumbricoides
Fatores Quimiotáticos de Eosinófilos
Fenômenos Fisiológicos da Nutrição Infantil
Helmintíase
Intestinos
Serviços de Saúde Escolar
Trichuris
-Parasitologia
Pediatria
Venezuela
Limites: Humanos
Masculino
Feminino
Criança
Tipo de Publ: Estudo Comparativo
Responsável: VE1.1 - Biblioteca Humberto Garcia Arocha


  2 / 8 LILACS  
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Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-402192
Autor: Weller, C. L; Jose, P. J; Williams, T. J.
Título: Selective suppression of leukocyte recruitment in allergic inflammation
Fonte: Mem. Inst. Oswaldo Cruz;100(supl.1):153-160, Mar. 2005.
Idioma: en.
Resumo: Allergic diseases result in a considerable socioeconomic burden. The incidence of allergic diseases, notably allergic asthma, has risen to high levels for reasons that are not entirely understood. With an increasing knowledge of underlying mechanisms, there is now more potential to target the inflammatory process rather than the overt symptoms. This focuses attention on the role of leukocytes especially Th2 lymphocytes that regulate allergic inflammation and effector cells where eosinophils have received much attention. Eosinophils are thought to be important based on the high numbers that are recruited to sites of allergic inflammation and the potential of these cells to effect both tissue injury and remodelling. It is hoped that future therapy will be directed towards specific leukocyte types, without overtly compromising essential host defence responses. One obvious target is leukocyte recruitment. This necessitates a detailed understanding of underlying mechanisms, particularly those involving soluble che-moattractants signals and cell-cell adhesion molecules.
Descritores: Quimiocinas/imunologia
Fatores Quimiotáticos de Eosinófilos/imunologia
Eosinófilos/imunologia
Inflamação/imunologia
Hipersensibilidade Respiratória/imunologia
-Quimiocinas/biossíntese
/imunologia
THTEMEFOS CELLS/imunologia
Limites: Animais
Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Revisão
Responsável: BR1.1 - BIREME


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Fotocópia
Id: lil-288062
Autor: Gennaro, Mónica de.
Título: Eosinofilias en pediatría / Hypereosinophilia in children
Fonte: Arch. argent. alerg. inmunol. clín;31(supl.2):60-9, 2000. tab.
Idioma: es.
Descritores: Eosinófilos/fisiologia
Eosinofilia/etiologia
-Hiperplasia Angiolinfoide com Eosinofilia/etiologia
Fatores Quimiotáticos de Eosinófilos
Eosinófilos
Eosinófilos/imunologia
Síndrome de Eosinofilia-Mialgia
Eosinofilia/diagnóstico
Eosinofilia/fisiopatologia
Mediadores da Inflamação
Eosinofilia Pulmonar
Programas de Autoavaliação
Síndrome Hipereosinofílica/diagnóstico
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Adolescente
Tipo de Publ: Revisão
Responsável: AR144.1 - CIBCHACO - Centro de Información Biomedica del Chaco


  4 / 8 LILACS  
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Texto completo SciELO Brasil
Texto completo
Id: lil-202035
Autor: Teixeira, Mauro M; Williams, Timothy J; Hellewell, Paul G.
Título: Description of an in vivo model for assessment of eosinophil chemoattractants in the mouse
Fonte: Mem. Inst. Oswaldo Cruz;92(supl.2):211-4, Dec. 1997. tab, graf.
Idioma: en.
Conferência: Apresentado em: New perspectives in eosinophils, Rio de Janeiro, 1996.
Resumo: Chemokines (chemoattractant cytokines) induce potent and selective chemotaxis of leukocyte subsets in vitro. Here, we review briefly the chemokines shown to induce eosinophil chemotaxis in vitro and describe a novel model for the study of the ability of chemokines to stimulate eosinophil migration in vivo. Eosinophils were purified from the blood of mice over-expressing the IL-5 gene and labelled with 111In. Only the C-C chemokines, eotaxin and MIP-1 alpha, but not RANTES, MCP-1, MCP-3, MIP-1ß. KC and MIP-2, effectively induced the recruitment of 111In-eosinophils in mouse skin. We suggest that this mouse model will be useful in assessing the role of endogenously-generated chemokines in mediating eosinophil migration to sites of allergic inflammation in vivo.
Descritores: Quimiocinas/fisiologia
Eosinófilos
Proteínas Quimioatraentes de Monócitos/fisiologia
-Movimento Celular/fisiologia
Fatores Quimiotáticos de Eosinófilos
Hipersensibilidade/fisiopatologia
Inflamação/fisiopatologia
Proteínas Inflamatórias de Macrófagos
Limites: Animais
Camundongos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


  5 / 8 LILACS  
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Texto completo SciELO Brasil
Texto completo SciELO Brasil
Texto completo
Texto completo
Id: lil-202034
Autor: Oliveira, Sandra H. P; Faccioli, Lúcia H; Ferreira, Sérgio H; Cunha, Fernando Q.
Título: Participation of interleukin-5, interleukin-8 and leukotriene B4 in eosinophil accumulation in two different experimental models
Fonte: Mem. Inst. Oswaldo Cruz;92(supl.2):205-10, Dec. 1997. graf.
Idioma: en.
Conferência: Apresentado em: New perspectives in eosinophils, Rio de Janeiro, 1996.
Resumo: There are several experimental models descibing in vivo eosinophil (EO) migration, including injection of a large volume of saline (SAL) or Sephadex beads (SEP). The aim of this study was to investigate the mechanisms involved in the EO migration in these two models. Two consecutive injections of SAL given 48 hr apart, induced a selective recruitment of EO into peritoneal cavity of rats, which peaked 48 hr after the last injection. SEP, when injected, promoted EO accumulation in rats. The phenomenom was dose-related and peaked 48 hr after injection. To investigate the mediators involved in this process we showed that BW A4C, MK 886 and dexamethasone (DXA) inhibited the EO migration induced by SAL and SEP. To investigate the source of the EO chemotactic factor we showed that mast cells, macrophages (MO), but not lymphocytes, incubated in vitro in presence of SAL released a factor which induced EO migration. With SEP, only mast cells release a factor that induced EO migration, which was inhibited by BW A4C, MK 886 and DXA. Furthermore, the chemotactic activity of SAL-stimulated mast cells was inhibited by antisera against IL-5 and IL-8 (interleukin). SAL-stimulated MO were only inhibited by anti-IL-8 antibodies as well as SEP-stimulated mast cells. These results suggest that the EO migration induced by SAL may be dependent on resident mast cells and MO mediated by LTB4, IL-5 and IL-8. SEP-induced EO migration was dependent on mast cells and may be mediated by LTB4 and IL-8. Furthermore, IL-5 and IL-8 induced EO migration, which was also dependent on resident cells and mediated by LTB4. In conclusion, EO migration induced by SAL is dependent on mast cells and MO, whereas that induced by SEP is dependent on mast cells alone. Stimulated mast cells release LTB4, IL-5 and IL-8 while MO release LTB4 and IL-8. The IL-5 and and IL-8 release by the SAL or SEP-stimulated resident cells may act in an autocrine fashion, thus potentiating LTB4 release.
Descritores: Movimento Celular/efeitos dos fármacos
Eosinófilos/fisiologia
Interleucina-5
Interleucina-8
Leucotrieno B4
-Fatores Quimiotáticos de Eosinófilos
Macrófagos
Mastócitos/efeitos dos fármacos
Limites: Animais
Ratos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


  6 / 8 LILACS  
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Texto completo SciELO Brasil
Alves, Alessandra C
Cordeiro, Renato S. B
Texto completo
Id: lil-202033
Autor: Alves, Alessandra C; Pires, Ana Lucia A; Lagente, Vincent; Cordeiro, Renato S. B; Martins, Marco A; Silva, Patricia M. R. e.
Título: Effect of selective phosphodiesterase inhibitors on the rat eosinophil chemotactic response in vitro
Fonte: Mem. Inst. Oswaldo Cruz;92(supl.2):201-4, Dec. 1997. tab, graf.
Idioma: en.
Conferência: Apresentado em: New perspectives in eosinophils, Rio de Janeiro, 1996.
Resumo: In the present study, we have performed a comparative analysis of the effect of selective inhibitors of phosphodiesterase (PDE) type III, IV and V on eosinophil chemotaxis triggered by platelet activating factor (PAF) and leukotriene B4 (LTB4) in vitro. The effect of the analogues N6-2'-O-dibutyryladenosine 3':5' cyclic monophosphate (Bt2 cyclic AMP) and N2-2'-O-dibutyrylguanosine 3':5' cyclic monophosphate (Bt2 cyclic GMP) has also been determined. The eosinophils were obtained from the peritoneal cavity of naive Wistar rats and purified in discontinuous Percoll gradients to 85-95 per cent purity. We observed that pre-incubation of eosinophils with the PDE type IV inhibitor rolipram suppressed the chemotactic response triggered by PAF and LTB4 in association with an increase in the intracellular levels of cyclic AMP. In contrast, neither zaprinast (type V inhibitor) nor type III inhibitors milrinone and SK&F 94836 affected the eosinophil migration. Only at the highest concentration tested did the analogue Bt2 cyclic AMP suppress the eosinophil chemotaxis, under conditions where Bt2 cyclic GMP was ineffective. We have concluded that inhibition of PDE IV, but not PDE III or V, was able to block the eosinophil chemotaxis in vitro, suggesting that the suppresive activity of selective PDE IV inhibitors on tissue eosinophil accumulation may, at least, be partially dependent on their ability to directly inhibit the eosinophil migration.
Descritores: Fatores Quimiotáticos de Eosinófilos
Técnicas In Vitro
Inibidores de Fosfodiesterase
-Movimento Celular/efeitos dos fármacos
Leucotrieno B4
Fator de Ativação de Plaquetas
Limites: Animais
Ratos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


  7 / 8 LILACS  
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Fotocópia
Id: lil-153019
Autor: Barriga, Omar O.
Título: The eosinophils in parasitic infections
Fonte: Parasitol. día;19(1/2):44-56, ene.-jun. 1995. ilus.
Idioma: en.
Resumo: Local and peripheal eosinophilia is a common feature of many helminth infections that present large, non-phagocytable surfaces to the inmune system. The effect of the eosinophils on these organisms has been studied in the last 18 years using schistosoma mansoni, trichinella spiralis, and other helminths as models. The early infection causes a nonspecific inflammation rich in macrophages, lymphocytes and neutrophils that sets the stage for a subsequent inmune response. The predominant effector elements of the inmune response are anaphylactic antibodies, mast cells, and eosinophils. Mast cell products attract eosinophils and concentrate antibodies and complement-covered parasites by their Fc and/or C3c receptors and release oxygen radicals and/or preformed proteins on the helmith surface. The radicals alter molecules of the parasite and the proteins disrupt its tegument or cuticle. Occasionally, they may harm host cells. Eosinophils also phagocytize and harm extracellular trypanosoma cruzi and may play a role in the damage to the host heart tissue. The eosinophil response is regulated by eosinophilopoietic factors (interleukines [IL] 3 and 5, and granulocyte macrophage colony-stimulating factor) eosinophilotactic factors (C5a from complement, eosinophil chemotactic factor of anaphylaxis [ECF-A], histamine, platelet stimulating factor, and other ECFs from mast cells and basophils, and ECF from parasites), and eosinophiloactivating factors (IL-5 from Th2 lymphocytes, tumor necrosis factor from macrophages, antibodies, and complement components). Other phagocytic cells (macrophages and neutrophils) also exhibit important anti-helminthic activities
Descritores: Eosinofilia/parasitologia
Sistema Imunitário/parasitologia
Doenças Parasitárias/imunologia
-Artrópodes
Infecções por Cestoides/imunologia
Fatores Quimiotáticos de Eosinófilos/imunologia
Controle de Infecções
Infecções por Nematoides/imunologia
Infecções por Protozoários/imunologia
Infecções por Trematódeos/imunologia
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Fotocópia
Id: lil-83193
Autor: Martins, M. A; Etienne, A; Soulard, C; Domingo, M. T; Braquet, P.
Título: Chemotactic effect of PAF-acether on peritoneal eosinophils from normal rats
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;22(9):1151-4, 1989. ilus.
Idioma: en.
Conferência: Apresentado em: Annual Meeting of the Federaçäo de Sociedades de Biologia Experimental, 4, Caxambu, June 28-July 2, 1989.
Resumo: The chemotactic activity of PAF-acether was compared with that of tetrapeptide eosinophil chemotactic factors of anaphylaxis (ECF-A, Ala-Gly-Ser Glu and Val-Gly-Ser-Glu) using eosinophils obtained from the peritoneal cavity of normal rats. Cells were isolated by separation over discontinuous metrizamide gradients which resulted in eosinophil suspensions of 80 to 90% purity. PAF-acether produced 7-fold greater than the maximal activity obtained with the ECF-A-tetrapeptides. BN 52021 and WEB 2086 inhibited PAF-acether-induced eosinophil chemotaxis in a dose-dependent manner, suggesting that this phenomenon is mediated by specific PAF-acether receptors
Descritores: Eosinófilos/fisiologia
Fator de Ativação de Plaquetas/antagonistas & inibidores
Fatores Quimiotáticos de Eosinófilos/farmacologia
Técnicas In Vitro
Cavidade Peritoneal/citologia
-Azepinas/farmacologia
Movimento Celular
Quimiotaxia
Lactonas/farmacologia
Ratos Endogâmicos
Triazinas/farmacologia
Limites: Ratos
Animais
Masculino
Tipo de Publ: Estudo Comparativo
Responsável: BR26.1 - Biblioteca Central



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