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Id: biblio-828162
Autor: Zurita, Jeannete; Barba, Pedro; Ortega-Paredes, David; Mora, Marcelo; Rivadeneira, Sebastián.
Título: Local circulating clones of Staphylococcus aureus in Ecuador
Fonte: Braz. j. infect. dis;20(6):525-533, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT The spread of pandemic Staphylococcus aureus clones, mainly methicillin-resistant S. aureus (MRSA), must be kept under surveillance to assemble an accurate, local epidemiological analysis. In Ecuador, the prevalence of the USA300 Latin American variant clone (USA300-LV) is well known; however, there is little information about other circulating clones. The aim of this work was to identify the sequence types (ST) using a Multiple-Locus Variable number tandem repeat Analysis 14-locus genotyping approach. We analyzed 132 S. aureus strains that were recovered from 2005 to 2013 and isolated in several clinical settings in Quito, Ecuador. MRSA isolates composed 46.97% (62/132) of the study population. Within MRSA, 37 isolates were related to the USA300-LV clone (ST8-MRSA-IV, Panton-Valentine Leukocidin [PVL] +) and 10 were related to the Brazilian clone (ST239-MRSA-III, PVL−). Additionally, two isolates (ST5-MRSA-II, PVL−) were related to the New York/Japan clone. One isolate was related to the Pediatric clone (ST5-MRSA-IV, PVL−), one isolate (ST45-MRSA-II, PVL−) was related to the USA600 clone, and one (ST22-MRSA-IV, PVL−) was related to the epidemic UK-EMRSA-15 clone. Moreover, the most prevalent MSSA sequence types were ST8 (11 isolates), ST45 (8 isolates), ST30 (8 isolates), ST5 (7 isolates) and ST22 (6 isolates). Additionally, we found one isolate that was related to the livestock associated S. aureus clone ST398. We conclude that in addition to the high prevalence of clone LV-ST8-MRSA-IV, other epidemic clones are circulating in Quito, such as the Brazilian, Pediatric and New York/Japan clones. The USA600 and UK-EMRSA-15 clones, which were not previously described in Ecuador, were also found. Moreover, we found evidence of the presence of the livestock associated clone ST398 in a hospital environment.
Descritores: Infecções Estafilocócicas/microbiologia
Staphylococcus aureus/genética
Toxinas Bacterianas/genética
Exotoxinas/genética
Leucocidinas/genética
Antibacterianos/farmacologia
-Staphylococcus aureus/isolamento & purificação
Staphylococcus aureus/classificação
DNA Bacteriano
Testes de Sensibilidade Microbiana
Prevalência
Fatores de Virulência/genética
Equador
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Staphylococcus aureus Resistente à Meticilina/classificação
Staphylococcus aureus Resistente à Meticilina/genética
Tipagem de Sequências Multilocus
Genótipo
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1038370
Autor: Gong, Zongrong; Shu, Min; Xia, Qing; Tan, Shan; Zhou, Wei; Zhu, Yu; Wan, Chaomin.
Título: Portación nasal deStaphylococcus aureus y sus perfiles de resistencia a antibióticos en niños que viven en zonas de gran altitud del sudoeste de China / Staphylococcus aureus nasal carriage and its antibiotic resistance profiles in children in high altitude areas of Southwestern China
Fonte: Arch. argent. pediatr;115(3):274-277, jun. 2017.
Idioma: en; es.
Resumo: Antecedentes/Objetivo. Describir el perfil epidemiológico de la portación nasal de cepas de Staphylococcus aureus (S. aureus), su resistencia a antibióticos y la presencia de los genes de leucocidina de Panton-Valentine (LPV) y mecA en niños en edad escolar que viven en zonas de gran altitud del sudoeste de China. Métodos. En el estudio transversal, se analizaron hisopados nasales de estudiantes a fin de detectar S. aureus. Se realizó la prueba de la reacción en cadena de la polimerasa (RCP) para identificar los genes de LPV y mecA. Resultados. Del total de 314 niños, se detectó S. aureus en el 5,10% (16/314). La resistencia de las cepas aisladas a la penicilina, eritromicina, clindamicina, rifampicina y cefoxitina fue del 100%, 81,3%, 81,3%, 0,0% y 6,3%, respectivamente. Ninguna de las cepas mostró resistencia a la vancomicina. Se detectó la expresión del gen mecA en 3 cepas aisladas, y 10 cepas aisladas dieron resultado positivo para el gen de LPV. Conclusión. Se detectó S. Aureus en el 5,10% (16/314) de la población del estudio; el 0,96% (3 /314) presentó S. Aureus resistente a la meticilina (SARM). Además, se detectó la expresión de los genes de LPV y mecA en 10 y 3 cepas aisladas, respectivamente.

Background/Aim. To describe the epidemiological profile of nasal carriage of Staphylococcus aureus (S. aureus) strains, its antibiotic resistance and mecA and Panton Valentine leukocidin (PVL) genes presence, in school children residing in high altitude areas of Southwestern China. Methods. The cross sectional study screened nasal swabs taken from students for S. aureus. PCR was performed to identify mecA and PVL genes. Results. Of the total 314 children 5.10% (16/314) was detected S. aureus. The resistance of isolated strains to penicillin, erythromycin, clindamycin, rifampicin and cefoxitin was 100%, 81.3%, 81.3%, 0.0%, and 6.3% respectively. No strains demonstrated resistance to vancomycin; expression of mecA gene was detected in 3 isolates and 10 isolates were PVL-positive. Conclusion. S. aureus was detected in 5.10% (16/314) of the study population; 0.96% (3/314) had methicillin resistant S. aureus (MRSA); expression of the mecA and PVL genes were detected in 3 and 10 isolates respectively.
Descritores: Staphylococcus aureus/efeitos dos fármacos
Portador Sadio/microbiologia
Nariz/microbiologia
Altitude
-Staphylococcus aureus/isolamento & purificação
Staphylococcus aureus/genética
Proteínas de Bactérias/genética
Toxinas Bacterianas/genética
China
Estudos Transversais
Farmacorresistência Bacteriana
Proteínas de Ligação às Penicilinas/genética
Exotoxinas/genética
Leucocidinas/genética
Limites: Humanos
Masculino
Feminino
Criança
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-838248
Autor: Brizuela, Martín; Pérez, Guadalupe; Ruvinsky, Silvina; Sarkis, Claudia; Romero, Romina; Mastroianni, Alejandra; Casimir, Lidia; Venuta, María E; Gómez Bonduele, Verónica; Bologna, Rosa.
Título: Infección grave por Staphylococcus aureus meticilino sensible productor de leucocidina de Panton-Valentine: reportes de dos casos / Severe infection by methicillin sensitive Staphylococcus aureus producing Panton-Valentine leukocidin: reports of two cases
Fonte: Arch. argent. pediatr;114(4):e237-e240, ago. 2016. ilus.
Idioma: es.
Resumo: Staphylococcus aureus es uno de los principales agentes etiológicos de infecciones en niños provenientes de la comunidad y del ámbito hospitalario. La gravedad de estos cuadros se asocia a factores de virulencia, entre los que se encuentra la leucocidina de Panton-Valentine. Tanto Staphylococcus aureus resistente como sensible a la meticilina producen esta leucocidina, aunque con frecuencia variable. Presentamos a dos niños con infección grave por Staphylococcus aureus sensible a la meticilina productor de leucocidina de Panton-Valentine con complicaciones osteoarticulares y endovasculares. Es fundamental la sospecha diagnóstica, el tratamiento antibiótico adecuado y el manejo quirúrgico precoz para mejorar el abordaje de estas infecciones. Se debe mantener la vigilancia epidemiológica para detectar la frecuencia de las infecciones causadas por estas bacterias.

Staphylococcus aureus is a major etiologic agent of infections in children from the community and the hospital setting. The severity of these conditions is associated with virulence factors, including the Panton-Valentine leukocidin. Both methicillin resistant and sensitive Staphylococcus aureus produce this leukocidin although with varying frequency. We present two children with severe infection by sensitive Staphylococcus aureus producer of Panton-Valentine leukocidin with musculoskeletal and endovascular complications. It is essential the suspected diagnosis, appropriate antibiotic treatment and early surgical management to improve the approach of these infections. Epidemiological surveillance should be mantained to detect the frequency of infections caused by these bacteria.
Descritores: Infecções Estafilocócicas/diagnóstico
Infecções Estafilocócicas/microbiologia
Infecções Estafilocócicas/terapia
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/metabolismo
Toxinas Bacterianas/biossíntese
Exotoxinas/biossíntese
Leucocidinas/biossíntese
Meticilina/farmacologia
Antibacterianos/farmacologia
-Índice de Gravidade de Doença
Testes de Sensibilidade Microbiana
Limites: Humanos
Masculino
Feminino
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-838186
Autor: Karli, Arzu; Yanik, Keramettin; Paksu, Muhammet S; Sensoy, Gulnar; Aykanat, Alper; Yener, Nazik; Belet, Nursen; Ceyhan, Meltem.
Título: Infección diseminada por Staphylococcus aureus positivo para leucocidina de Panton-Valentine en un niño / Disseminated Panton-Valentine Leukocidin-Positive Staphylococcus aureus infection in a child
Fonte: Arch. argent. pediatr;114(2):e75-e77, abr. 2016. ilus.
Idioma: en; es.
Resumo: La leucocidina de Panton-Valentine (LPV) es una exotoxina producida por muchas cepas de Staphylococcus aureus, y un importante factor de virulencia. Una infección por S. aureus positivo para LPV deriva en infecciones rápidas y graves de partes blandas y neumonía necrosante en adolescentes sanos, y la tasa de mortalidad es elevada. Presentamos el caso de un paciente de 12 años hospitalizado por fiebre, dificultad respiratoria y coxalgia en el que se identificó neumonía necrosante con embolia pulmonar séptica, absceso del psoas, celulitis y osteomielitis. En el hemocultivo del paciente se aisló S. aureus sensible a la meticilina (SASM) positivo para LPV.

Panton-Valentine leukocidin (PVL) is an exotoxin that is produced by many strains of Staphylococcus aureus, and an important virulence factor. A PVL-positive S. aureus infection leads to rapid and severe infections of soft tissue and necrotizing pneumonia in healthy adolescents, and has a high mortality. This case report included a 12-year-old male patient who admitted for fever, respiratory distress and hip pain and was identified with necrotizing pneumonia with septic pulmonary embolism, psoas abscess, cellulitis and osteomyelitis. The PVL positive methicillin-sensitive S. aureus (MSSA) was isolated in the patient blood culture.
Descritores: Infecções Estafilocócicas/diagnóstico
Staphylococcus aureus
Toxinas Bacterianas/análise
Infecções Comunitárias Adquiridas
Exotoxinas/análise
Leucocidinas/análise
Limites: Humanos
Masculino
Criança
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-1016080
Autor: Oppermann, Tobias; Busse, Nadine; Czermak, Peter.
Título: Mannheimia haemolytica growth and leukotoxin production for vaccine manufacturing: a bioprocess review
Fonte: Electron. j. biotechnol;28:95-100, July. 2017. tab.
Idioma: en.
Resumo: Mannheimia haemolytica leukotoxin (LKT) is a known cause of bovine respiratory disease (BRD) which results in severe economic losses in the cattle industry (up to USD 1 billion per year in the USA). Vaccines based on LKT offer the most promising measure to contain BRD outbreaks and are already commercially available. However, insufficient LKT yields, predominantly reflecting a lack of knowledge about the LKT expression process, remain a significant engineering problem and further bioprocess optimization is required to increase process efficiency. Most previous investigations have focused on LKT activity and cell growth, but neither of these parameters defines reliable criteria for the improvement of LKT yields. In this article, we review the most important process conditions and operational parameters (temperature, pH, substrate concentration, dissolved oxygen level, medium composition and the presence of metabolites) from a bioprocess engineering perspective, in order to maximize LKT yields.
Descritores: Toxinas Bacterianas/biossíntese
Mannheimia haemolytica/metabolismo
Complexo Respiratório Bovino/microbiologia
Exotoxinas/biossíntese
-Temperatura
Oligoelementos
Carbono/metabolismo
Mannheimia haemolytica/patogenicidade
Aminoácidos/metabolismo
Concentração de Íons de Hidrogênio
Cinetina
Limites: Animais
Bovinos
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-840311
Autor: Oppermann, Tobias; Schwarz, Stefan; Busse, Nadine; Czermak, Peter.
Título: A fast and simple assay to quantify bacterial leukotoxin activity
Fonte: Electron. j. biotechnol;19(6):38-42, Nov. 2016. ilus.
Idioma: en.
Resumo: Background: Mannheimia haemolytica is the primary bacterial pathogen in causing bovine respiratory disease with tremendous annual losses in the cattle industry. The leukotoxin from M. haemolytica is the predominant virulence factor. Several leukotoxin activity assays are available but not standardized regarding sample preparation and cell line. Furthermore, these assays suffer from a high standard error, a prolonged time consumption and often complex sample pretreatments, which is important from the bioprocess engineering point of view. Results: Within this study, an activity assay based on the continuous cell line BL3.1 combined with a commercial available adenosine triphosphate viability assay kit was established. The leukotoxin activity was found to be strongly dependent on the sample preparation. Furthermore, the interfering effect of lipopolysaccharides in the sample could be successfully suppressed by adding polymyxin B. We reached a maximum relative P95 value of 14%, which is more than seven times lower compared to current available assays as well as a time reduction up to 88%. Conclusion: Ultimately, the established leukotoxin activity assay is simple, fast and has a high reproducibility. Critical parameters regarding the sample preparation were characterized and optimized making complex sample purification superfluous.
Descritores: Complexo Respiratório Bovino/microbiologia
Exotoxinas/análise
Mannheimia haemolytica/patogenicidade
Técnicas Microbiológicas
-Trifosfato de Adenosina
Lipopolissacarídeos
Polimixina B
Limites: Animais
Responsável: CL1.1 - Biblioteca Central


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Id: lil-741293
Autor: Bonesso, Mariana Fávero; Marques, Silvio Alencar; Camargo, Carlos Henrique; Fortaleza, Carlos Magno Castelo Branco; Cunha, Maria de Lourdes Ribeiro de Souza da.
Título: Community-associated methicillin-resistant Staphylococcus aureus in non-outbreak skin infections
Fonte: Braz. j. microbiol;45(4):1401-1407, Oct.-Dec. 2014. ilus, tab.
Idioma: en.
Projeto: São Paulo Research Foundation; . CAPES.
Resumo: The aim of this study was to determine the prevalence of Staphylococcus aureus and risk factors for the acquisition of MRSA (Methicillin Resistant Staphylococcus aureus) as the main cause of skin and soft tissue infections. S. aureus were characterized for the presence of PVL, TSST-1 and mecA genes. SCCmec typing was carried out in mecA positive strains and PFGE was performed only in these strains. During the study period, 127 outpatients attending a dermatology clinical the Botucatu Medical School, a regional tertiary hospital in Botucatu, Sao Paulo, Brazil, were diagnosed with active skin infections. A total 66 (56.9%) S. aureus strains were isolated. The methicillin resistance gene mecA was detected in seven (10.6%) S. aureus strains. The SCCmec types detected in the seven mecA-positive S. aureus strains were type Ia in one, type II in three, and type IV in three. The PVL gene was detected in 10 (15.1%) in sensitive strains. Pulsed field gel electrophoresis revealed non-clonal diversity among the isolates. The risk factors associated with MRSA acquisition in this study were previous ciprofloxacin use and working in a healthcare environment. The risk factors indicate plausible routes of CA-MRSA transmission among the subjects studied.
Descritores: Infecções Comunitárias Adquiridas/epidemiologia
Infecções Comunitárias Adquiridas/microbiologia
Surtos de Doenças
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Infecções Cutâneas Estafilocócicas/epidemiologia
Infecções Cutâneas Estafilocócicas/microbiologia
-Brasil
Proteínas de Bactérias/genética
Toxinas Bacterianas/genética
Eletroforese em Gel de Campo Pulsado
Enterotoxinas/genética
Exotoxinas/genética
Variação Genética
Leucocidinas/genética
Epidemiologia Molecular
Tipagem Molecular
Staphylococcus aureus Resistente à Meticilina/genética
Prevalência
Fatores de Risco
Pele/microbiologia
Superantígenos/genética
Limites: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Criança
Pré-Escolar
Feminino
Humanos
Lactente
Masculino
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-712957
Autor: Elisabeth, Paramythiotou; Maria, Souli; Irene, Galani; Helen, Giamarellou; Apostolos, Armaganidis.
Título: Success stories about severe pneumonia caused by Panton-Valentine leucocidin-producing Staphylococcus aureus
Fonte: Braz. j. infect. dis;18(3):341-345, May-June/2014. tab, graf.
Idioma: en.
Resumo: We describe three cases of community-acquired necrotizing pneumonia which were caused by Panton-Valentine leucocidin-producing strains of Staphylococcus aureus (one of them methicillin sensitive). All cases were successfully treated without any sequelae for the patients due to the prompt initiation of adequate antimicrobial therapy. High suspicion toward this fatal pathogen was the key to the successful outcome of the patients.
Descritores: Toxinas Bacterianas/biossíntese
Exotoxinas/biossíntese
Leucocidinas/biossíntese
Pneumonia Estafilocócica/diagnóstico
Staphylococcus aureus/metabolismo
-Infecções Comunitárias Adquiridas/diagnóstico
Infecções Comunitárias Adquiridas/microbiologia
Infecções Comunitárias Adquiridas/patologia
Necrose/microbiologia
Necrose/patologia
Pneumonia Estafilocócica/microbiologia
Pneumonia Estafilocócica/patologia
Índice de Gravidade de Doença
Limites: Adolescente
Adulto
Feminino
Humanos
Masculino
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-712433
Autor: Machuca, Mayra Alejandra; González, Clara Isabel; Sosa, Luis Miguel.
Título: Methicillin-resistant Staphylococcus aureus causes both c ommunity-associated and health care-associated infections in children at the Hospital Universitario de Santander / Staphylococcus aureus resistente a meticilina causante de infecciones comunitarias y de infecciones asociadas a la atención en salud en pacientes pediátricos del Hospital Universitario de Santander
Fonte: Biomédica (Bogotá);34(supl.1):163-169, abr. 2014. tab.
Idioma: en.
Resumo: Introduction: Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of infection in the pediatric population. Initially, MRSA was restricted to hospitals; however, outbreaks in the community among people without health care-related risk factors have been reported worldwide. Currently, MRSA is a frequent cause of both hospital and community-associated infections. Objective: To describe the relationships between the molecular characteristics of MRSA isolates (staphylococcal cassette chromosome mec (SCCmec) type and Panton-Valentine leukocidin (PVL) carriage) and the characteristics of infection (the origin and localization of infection) in pediatric patients at the Hospital Universitario de Santander in Bucaramanga, Colombia. Materials and methods: A total of 43 MRSA isolates were obtained from hospitalized pediatric patients. SCCmec typing (I-V), SCCmec IV subtyping and PVL carriage were determined and related to the clinical characteristics. Results: Among the MRSA isolates studied, SCCmec IVc was present in 77%, followed by 16% for SCCmec I and 2% for SCCmec IVa. Two isolates were not typeable (NT). PVL genes were carried by 88% of the MRSA isolates, including the SCCmec IVc/IVa and SCCmec I isolates. SCCmec IV caused both community-acquired infection (CAI) (47%) and nosocomial infection (HAI) (53%). SCCmec IV, PVL-positive MRSA was associated with both CAI (47%) and HAI (53%) and caused mostly SSTI and osteoarticular infection. Conclusions: These findings suggest that the presence of community-associated MRSA (CA-MRSA) (SCCmec IV and PVL positive) causes both health care-associated infection (HCAI) and nosocomial infection (HAI) in pediatric patients in Colombia.

Introducción. Staphylococcus aureus resistente a la meticilina (SARM) es un agente frecuente de infección en la población pediátrica. Aunque inicialmente las cepas de SARM estaban restringidas a los hospitales, se han reportado a nivel mundial brotes de infección por SARM en individuos sin factores de riesgo y, actualmente, SARM es una causa frecuente de infecciones hospitalarias y comunitarias. Objetivo. Describir la relación entre las características moleculares de aislamientos de SARM (casete cromosómico estafilocócico mec SCCmec y leucocidina Panton-Valentine) y el origen de la infección y su presentación clínica en pacientes pediátricos del Hospital Universitario de Santander en Bucaramanga, Colombia. Materiales y métodos. Se incluyeron 43 aislamientos de SARM obtenidos de niños hospitalizados. La clasificación del SCCmec (I-V) y la subclasificación del SCCmec-IV se realizaron en todos los aislamientos. Además, los genes de la leucocidina Panton-Valentine se detectaron mediante amplificación por PCR. Las características moleculares fueron asociadas con las características clínicas de cada paciente. Resultados. Entre los 43 SARM tipificados, el SCCmec-IVc fue el más frecuente con 77 %, seguido por el SCCmec-I con 16 % y el SCCmec-IVa con 2 %. Tres aislamientos no pudieron ser tipificados. Los genes de la leucocidina Panton Valentine se detectaron en 88 % de los SARM en aislamientos portadores del SCCmec-IVc/IVa y el SCCmec-I. Los SARM SCCmec-IV positivos para la leucocidina Panton-Valentine se asociaron con infecciones adquiridas en la comunidad (47 %) y en el hospital (53 %) con compromiso de piel y tejidos blandos, y en los casos más graves, con compromiso osteoarticular. Conclusiones. Estos resultados sugieren la presencia de cepas SARM-CO (SCCmec-IV positiva para PVL) causantes de infecciones adquiridas en la comunidad y en el medio hospitalario en pacientes pediátricos en Colombia.
Descritores: Infecções Comunitárias Adquiridas/microbiologia
Infecção Hospitalar/microbiologia
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Infecções Estafilocócicas/microbiologia
-Técnicas de Tipagem Bacteriana
Proteínas de Bactérias/genética
Toxinas Bacterianas/genética
Colômbia/epidemiologia
Infecções Comunitárias Adquiridas/epidemiologia
Infecção Hospitalar/epidemiologia
Farmacorresistência Bacteriana Múltipla
Exotoxinas/genética
Hospitais Universitários/estatística & dados numéricos
Leucocidinas/genética
Resistência a Meticilina/genética
Staphylococcus aureus Resistente à Meticilina/classificação
Staphylococcus aureus Resistente à Meticilina/genética
Infecções Estafilocócicas/epidemiologia
Centros de Atenção Terciária/estatística & dados numéricos
Limites: Adolescente
Criança
Pré-Escolar
Feminino
Humanos
Lactente
Recém-Nascido
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CO332 - Facultad de Medicina


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Asensi, Marise Dutra
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Id: lil-699818
Autor: Brust, Társis; Costa, Thaina Miranda da; Amorim, José Carlos; Asensi, Marise Dutra; Fernandes, Octavio; Aguiar-Alves, Fábio.
Título: Hospital-associated methicillin-resistant Staphylococcus aureus carrying the PVL gene outbreak in a Public Hospital in Rio de Janeiro, Brazil
Fonte: Braz. j. microbiol;44(3):865-868, July-Sept. 2013. ilus.
Idioma: en.
Resumo: Hospital associated methicillin-resist Staphylococcus aureus has long been associated to outbreaks in the hospital environment. In this work, we investigated an outbreak of Hospital associated methicillin-resist Staphylococcus aureus carrying the Panton-Valentine leukocidin gene, which occurred in a large community hospital in Rio de Janeiro, Brazil.
Descritores: Toxinas Bacterianas/genética
Infecção Hospitalar/epidemiologia
Surtos de Doenças
Exotoxinas/genética
Leucocidinas/genética
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Infecções Estafilocócicas/epidemiologia
-Brasil/epidemiologia
Portador Sadio/epidemiologia
Portador Sadio/microbiologia
Infecção Hospitalar/microbiologia
Eletroforese em Gel de Campo Pulsado
Genótipo
Hospitais Públicos
Epidemiologia Molecular
Tipagem Molecular
Staphylococcus aureus Resistente à Meticilina/genética
Cavidade Nasal/microbiologia
Infecções Estafilocócicas/microbiologia
Fatores de Virulência/genética
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde