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Id: biblio-1040162
Autor: Dias, Fernando José; Arias, Alain; Borie, Eduardo; Lezcano, Maria Florencia; Arellano-Villalón, Manuel; Fuentes, Ramón.
Título: Comparison of morphological quantitative characteristics of the newly formed alveolar bone after the application of demineralized bone matrix and cortical bone allografts / Comparación de las características morfológicas cuantitativas del hueso alveolar recién formado después de la aplicación de matriz ósea desmineralizada y aloinjertos de hueso cortical
Fonte: Int. j. morphol;37(4):1509-1516, Dec. 2019. graf.
Idioma: en.
Resumo: The allografts were used to obtain sufficient alveolar bone tissue for proper dental implant placement. The objective of the present study was to evaluate the morphological and quantitative characteristics (cellular and collagen densities) of the newly formed alveolar bone with the application of cortical bone (CB) and demineralized bone matrix (DBM) allografts. Six samples of alveolar bone tissue from 5 patients (50 ± 6.3 years) were obtained after 6 months of application of the allografts and immediately before the placement of the dental implants. The samples were fixed (buffered formaldehyde, pH7.2), decalcified (EDTA 10 %) and histologically processed (HE and Picro-Sirius) for histologic analysis. Morphological analysis revealed presence of osteocytes and trabeculae in neoformed bone tissue near the allografts and absence of inflammatory and allergic cells; the remnants of CB were located mainly in the periphery of the bone tissue and the remnants of DBM were more incorporated into the tissue. Osteogenitor cells were observed around the remaining material. The cell density was not modified in newly formed bone tissue with the application of both allografts as compared to mature bone tissue. The density of the type I and III collagens present in the osteoids interspersed with the remainder of the materials showed a tendency to increase in the samples treated with DBM. It was concluded that by the histological characteristics observed both grafts were biocompatible, however the bone treated with DBM presented better incorporation and a tendency of increase of the collagen content in the remnant region of the allografts.

Los aloinjertos son utilizados para obtener tejido óseo alveolar apropiado para la colocación correcta del implante dental. El objetivo de este trabajo fue evaluar las características morfológicas y cuantitativas (densidades celulares y de colágeno) del hueso alveolar recién formado con la aplicación de aloinjertos de hueso cortical (CB) y matriz desmineralizada de hueso (DBM). Seis muestras de tejido óseo alveolar fueron obtenidas de 5 pacientes (50 ± 6,3 años) después de 6 meses de aplicación de los aloinjertos e inmediatamente antes de la colocación de los implantes dentales. Las muestras fueron fijadas (formaldehído tamponado, pH 7,2), descalcificadas (EDTA al 10%) y procesadas histológicamente (HE y Picro-Sirius) para el análisis histológico. El análisis morfológico reveló la presencia de osteocitos y trabéculas en el tejido óseo neoformado cerca de los aloinjertos y la ausencia de células inflamatorias y alérgicas; los remanentes de CB se ubicaron principalmente en la periferia del tejido óseo y los remanentes de DBM se incorporaron más en el tejido. Se observaron células osteogenitoras alrededor del material restante. La densidad celular no se modificó en el tejido óseo recién formado con la aplicación de ambos aloinjertos en comparación con el tejido óseo maduro. La densidad de los colágenos de tipo I y III presentes en los osteoides intercalados con el resto de los materiales mostró una tendencia a aumentar en las muestras tratadas con DBM. Se concluyó que, debido a las características histológicas observadas, ambos injertos fueron biocompatibles, sin embargo, el hueso tratado con DBM presentó una mejor incorporación y una tendencia al aumento del contenido de colágeno en la región remanente de los aloinjertos.
Descritores: Matriz Óssea/transplante
Processo Alveolar/anatomia & histologia
Processo Alveolar/cirurgia
Aloenxertos
-Materiais Biocompatíveis
Regeneração Óssea
Transplante Ósseo
Substitutos Ósseos
Processo Alveolar/crescimento & desenvolvimento
Osso Cortical/transplante
Limites: Seres Humanos
Masculino
Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-840303
Autor: Silva, Henrique Celestino Lima e; Cheim Junior, Adonai Peixoto; Moreno, Roberto; Miranda, Sérgio Luis de.
Título: Off-label use of rhBMP-2 as bone regeneration strategies in mandibular ameloblastoma unicystic / Utilização off-label das rhBMP-2 como estratégia de regeneração do tecido ósseo em ameloblastoma mandibular
Fonte: Einstein (Säo Paulo);15(1):92-95, Jan.-Mar. 2017. graf.
Idioma: en.
Resumo: ABSTRACT Jawbone reconstruction after tumor resection is one of the most challenging clinical tasks for maxillofacial surgeons. Osteogenic, osteoinductive, osteoconductive and non-antigenic properties of autogenous bone place this bone as the gold standard for solving problems of bone availability. However, the need for a second surgical site to harvest the bone graft increases significantly both the cost and the morbidity associated with the reconstructive procedures. Bone grafting gained an important tool with the discovery of bone morphogenetic proteins in 1960. Benefit of obtaining functional and real bone matrix without need of second surgical site seems to be the great advantage of use bone morphogenetic proteins. This study analyzed the use of rhBMP-2 in unicystic ameloblastoma of the mandible, detailing its structure, mechanisms of cell signaling and biological efficacy, in addition to present possible advantages and disadvantages of clinical use of rhBMP-2 as bone regeneration strategy.

RESUMO A reconstrução óssea dos maxilares após ressecções tumorais é uma das tarefas mais difíceis para o cirurgião maxilofacial. As propriedades osteogênicas, osteoindutoras, osteocondutoras e não antigênicas do osso autógeno o colocam como o padrão-ouro para a solução de problemas de disponibilidade óssea. Entretanto a coleta do enxerto ósseo necessita de um segundo sítio cirúrgico, aumentando significativamente o custo e a morbidade associados ao procedimento reconstrutivo. A enxertia óssea ganhou uma excelente ferramenta com a descoberta das proteínas ósseas morfogenéticas na década de 1960. O benefício da obtenção de matriz óssea verdadeira e funcional, sem a necessidade de um segundo sítio cirúrgico, parece ser a grande vantagem do uso das proteínas ósseas morfogenéticas. Neste contexto, o objetivo deste estudo foi analisar a utilização da rhBMP-2 na regeneração óssea de ameloblastoma mandibular unicístico, detalhando sua estrutura, seus mecanismos de sinalização celular e sua eficácia biológica, além de apresentar potenciais vantagens e desvantagens da utilização clínica das rhBMP-2, enquanto estratégia regenerativa.
Descritores: Regeneração Óssea/efeitos dos fármacos
Ameloblastoma/cirurgia
Neoplasias Mandibulares/cirurgia
Fator de Crescimento Transformador beta
Transplante Ósseo/métodos
Proteína Morfogenética Óssea 2/uso terapêutico
Uso Off-Label
-Proteínas Recombinantes/uso terapêutico
Radiografia Panorâmica
Ameloblastoma/tratamento farmacológico
Ameloblastoma/diagnóstico por imagem
Neoplasias Mandibulares/tratamento farmacológico
Neoplasias Mandibulares/diagnóstico por imagem
Tomografia Computadorizada por Raios X
Reprodutibilidade dos Testes
Resultado do Tratamento
Substitutos Ósseos/uso terapêutico
Fotografias
Limites: Seres Humanos
Masculino
Adolescente
Responsável: BR1.1 - BIREME


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Id: lil-674974
Autor: Skorepa, Guillermo; Tejada, Gonzalo; Carboni Biso, Martin.
Título: Osteotomías proximales aditivas de tibia usando sustituto óseo. Estudio comparativo / Tibial proximal adding osteotomy using bone substitutes. Comparative study
Fonte: Artrosc. (B. Aires);19(4):173-177, dic. 2012.
Idioma: es.
Resumo: Objetivos: demostrar la relación del uso del sustituto óseo con un menor tiempo de consolidación y la menor agresión al paciente. Material y Métodos: Estudio retrospectivo y comparativo, de dos grupos de pacientes. Grupo A: 13 pacientes (8 hombres y 5 mujeres) con gonartrosis medial y genu varo, tratados con osteotomías de apertura sin sustituto óseo, edad media 53 años. Grupo B: 15 pacientes (12 hombres y 3 mujeres) con osteotomías de apertura con la utilización de sustituto óseo, edad media 48 años. Ambas osteotomías se realizaron con placas tipo Puddu no bloqueadas. Se tomaron radiografías en el postoperatorio inmediato y cada 15 días, para tener un seguimiento de la consolidación en ambos grupos. Resultados: En el grupo que se utilizó el sustituto óseo, el tiempo de consolidación fue menor con un promedio de 35 días acortando el tiempo de reinserción a las actividades cotidianas. Conclusion: El uso de sustituto óseo en osteotomía de apertura logra conseguir una consolidación pronta, acortando los tiempos de rehabilitación y de reinserción laboral. Tipo de Estudio: Terapéutico. Nivel de evidencia IV.
Descritores: Articulação do Joelho/cirurgia
Osteotomia/métodos
Substitutos Ósseos/uso terapêutico
Tíbia/cirurgia
-Estudos Retrospectivos
Seguimentos
Osteoartrite do Joelho/cirurgia
Procedimentos Cirúrgicos Minimamente Invasivos/métodos
Limites: Adulto
Meia-Idade
Tipo de Publ: Estudo Comparativo
Responsável: AR337.1 - Biblioteca A.A.O.T.


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Id: lil-731436
Autor: Chahla, Jorge; Arroquy, Damian; Gomez Rodriguez, Gustavo; Vilaseca, Tomas; Guiñazu, Jorge; Nazur, Gabriel; Carboni, Martin.
Título: Osteotomía valguizante tibial alta: comparación de resultados con el uso de aloinjerto y sustituto óseo / High tibial osteotomy. Allograft versus bone substitute
Fonte: Artrosc. (B. Aires);21(3):89-94, sept. 2014. ilus, tab, graf.
Idioma: es.
Resumo: Introducción: El relleno de la brecha producido por una osteotomía tibial proximal valguizante de apertura (OTA), se encuentra en constante discusión, dado los resultados dispares obtenidos por los distintos autores. El objetivo del siguiente trabajo fue comparar los resultados tanto radiológicos como clínicos con el uso de sustituto óseo y aloinjerto. Materiales y Método: Entre 2009 y 2012, se realizaron 34 OTA. La muestra fue dividida en dos grupos, 15 pacientes en los cuales se había utilizado sustituto óseo (SO) y 19 pacientes en los que se colocó aloinjerto óseo estructural (AI). El grado de artrosis fue estadificado preoperatoriamente según la clasificación de Ahlbãck e intraoperatoriamente estadificamos las lesiones de cartílago según la clasificación de Outerbridge. El análisis clínico se realizó mediante la Escala de la Sociedad de Rodilla (Knee Society Score) y la Escala de Oxford. El seguimiento del tiempo de consolidación, eje anatómico, eje mecánico y mantenimiento de la corrección (diferencia en milímetros) se realizó mediante radiografías con un seguimiento mínimo de un año. Resultados: La unión ósea ocurrió en la totalidad de las osteotomías, siendo el tiempo de consolidación ósea de 4,3 meses (50 días – 6 meses) en el grupo SO y de 3,2 meses (40 días – 5 meses) en el grupo AI (p=0,7). Se obtuvo una mejoría promedio del Knee Score y del Knee function de 20,3 y de 14,8 puntos respectivamente en el grupo SO y de 21,3 y 19,1 puntos en el grupo AI. La evaluación con el Oxford Score evidencio una mejoría promedio en el grupo SO de 21 puntos y de 29 puntos en el grupo AI. Por lo referido anteriormente no encontramos diferencias significativas entre ambos grupos en la evaluación funcional de los pacientes. Tuvimos dos casos descriptos de perdida de corrección que ocurrieron en el grupo SO, a diferencia del grupo AI en el que no apareció ninguna perdida de corrección no siendo esta una diferencia estadísticamente significativa (p=0,09). Conclusión: Ambos materiales tienen resultados clínicos e índices de consolidación comparables, pero con un mayor riesgo de pérdida de corrección de las osteotomías con sustituto óseo. Nivel de Evidencia: IV

Introduction: Given the disparate results obtained by different authors concerning the material to fill the bone gap produced by an opening high tibial osteotomy (HTO) the decision remains controversial. Good and very good results have been reported with bone substitute wedges and allograft, which avoid the inconveniences of autologous grafts use. The purpose of this study was to compare both radiological and clinical results using allograft and bone substitute. Material and Methods: We retrospectively analyzed 34 opening wedge HTO filled with allograft or bone substitute (from 2009 to 2012). We divided the sample into two groups: BS (Bone substitute) group was conformed by 15 patients and the AG (Allograft) group with 19 patients. The degree of osteoarthritis was staged preoperatively and intraoperatively we stratified condral lesions according to the classification of Ahlbãck and Outerbridge respectively. The clinical analysis was performed using the Knee Society Score and Oxford Knee Score. We analyzed time to consolidation, anatomical and mechanical axis and loss of correction (measured in millimeters) using X-rays. Results: Union occurred in every osteotomy, mean time was of 4,3 months in the BS group and 3,2 months in the AG group (p: 0,7). The knee society score (Knee Score and Knee function) were 20,3 and 14,8 points respectively in the BS group, and 21,3 and 19,1 in the AG group. The evaluation with the Oxford Score was 21 points in the BS group and 29 in the AG Group. As mentioned above, we did not found significant differences between groups in the functional assessment of patients. We had two cases of loss of correction in the BS group, and none in the AG group (p = 0.09). Conclusion: The results shows that there was no statistical difference between the two groups for overall complications. However, clinical results filling with bone substitute was less tolerated and increased the risk of loss of correction. Level of Evidence: IV
Descritores: Aloenxertos
Articulação do Joelho/cirurgia
Osteoartrite do Joelho/cirurgia
Osteotomia
Substitutos Ósseos
Tíbia/cirurgia
-Estudos Retrospectivos
Resultado do Tratamento
Limites: Adulto
Meia-Idade
Responsável: AR337.1 - Biblioteca A.A.O.T.


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Id: lil-794503
Autor: Cardoso, Camila L; Curra, Cláudia; Santos, Pâmela L; Rodrigues, Maria F. M; Ferreira-Júnior, Osny; de Carvalho, Paulo S. P.
Título: Current considerations on bone substitutes in maxillary sinus lifting / Consideraciones actuales sobre sustitutos óseos en elevación del seno maxilar
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);9(2):102-107, ago. 2016.
Idioma: en.
Projeto: São Paulo Research Foundation.
Resumo: The procedure of maxillary sinus lifting using autogenous bone was considered the reference standard choice for oral rehabilitation in cases of severe atrophic maxilla. However, it is not always a viable option, due to the limitations or morbidity caused by grafting techniques. This has led to the development of bone substitutes, which have been elaborated and improved. Choosing the best biomaterial becomes difficult due to the wide variety of bone substitutes. The aim of this article is to present some of these materials that are reported in the current scientific literature for maxillary sinus lifting.

El procedimiento de elevación del seno maxilar utilizando hueso autógeno se consideraba la opción estándar de oro para la rehabilitación oral en casos de maxilar atrófico grave. Sin embargo, no siempre es una opción viable, debido a las limitaciones o a la morbilidad causada por técnicas de injerto, lo que justifica la existencia de sustitutos óseos que han sido elaborados y mejorados. En cuanto a la amplia variedad de sustitutos óseos, se hace difícil la mejor elección de biomaterial. El objetivo de este informe es presentar una variedad de sustitutos óseos respetados en la literatura científica actual, usados en la elevación del seno maxilar.
Descritores: Materiais Biocompatíveis
Substitutos Ósseos
Levantamento do Assoalho do Seio Maxilar
-Polímeros
Cerâmica
Transplante Ósseo
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: CL58.1 - Biblioteca


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Id: lil-792600
Autor: DOI, Kazuya; KUBO, Takayasu; MAKIHARA, Yusuke; OUE, Hiroshi; MORITA, Koji; OKI, Yoshifumi; KAJIHARA, Shiho; TSUGA, Kazuhiro.
Título: Osseointegration aspects of placed implant in bone reconstruction with newly developed block-type interconnected porous calcium hydroxyapatite
Fonte: J. appl. oral sci;24(4):325-331, July-Aug. 2016. tab, graf.
Idioma: en.
Projeto: Japan Society for the Promotion of Science.
Resumo: ABSTRACT Artificial bone has been employed to reconstruct bone defects. However, only few reports on implant placement after block bone grafting exist. Objectives The purpose of this study was to evaluate the osseointegration of dental implant in bone reconstructions with interconnected porous calcium hydroxyapatite (IP-CHA). Material and Methods The IP-CHA cylinders (D; 4.3 mm, H; 10.0 mm) were placed into bone sockets in each side of the femurs of four male dogs. The IP-CHA on the right side was a 24-week sample. Twelve weeks after placement, a titanium implant was placed into a socket that was prepared in half of the placed IP-CHA cylinder on the right side. On the left side, another IP-CHA cylinder was placed as a 12-week sample. After another 12 weeks, the samples were harvested, and the bone regeneration and bone-implant contact (BIC) ratios were measured. Results New bone formation area was superior in the 24-week IP-CHA compared with the 12-week IP-CHA. BIC was not significantly different between IP-CHA and the parent sites. Osseointegration was detected around the implant in IP-CHA-reconstructed bone. Conclusion Our preliminary results suggest that IP-CHA may be a suitable bone graft material for reconstructing bones that require implant placement.
Descritores: Osseointegração/efeitos dos fármacos
Transplante Ósseo/métodos
Durapatita/farmacologia
Substitutos Ósseos/farmacologia
Implantação Dentária Endo-Óssea/métodos
-Propriedades de Superfície
Fatores de Tempo
Titânio/química
Teste de Materiais
Microscopia Eletrônica de Varredura
Reprodutibilidade dos Testes
Planejamento de Prótese Dentária
Implantes Experimentais
Fêmur/cirurgia
Limites: Animais
Masculino
Cães
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-779903
Autor: RAHMAN, Mohammad Zeshaan; SHIGEISHI, Hideo; SASAKI, Kazuki; OTA, Akira; OHTA, Kouji; TAKECHI, Masaaki.
Título: Combined effects of melatonin and FGF-2 on mouse preosteoblast behavior within interconnected porous hydroxyapatite ceramics - in vitro analysis
Fonte: J. appl. oral sci;24(2):153-161, Mar.-Apr. 2016. graf.
Idioma: en.
Projeto: Ministry of Education, Culture, Sports, Science and Technology.
Resumo: ABSTRACT Objective Biocompatible materials such as interconnected porous hydroxyapatite ceramics (IP-CHA) loaded with osteogenic cells and bioactive agents are part of an evolving concept for overcoming craniofacial defects by use of artificial bone tissue regeneration. Amongst the bioactive agents, melatonin (MEL) and basic fibroblast growth factor (FGF-2) have been independently reported to induce osteoblastic activity. The present in vitro study was undertaken to examine the relationship between these two bioactive agents and their combinatory effects on osteoblastic activity and mineralization in vitro. Material and Methods Mouse preosteoblast cells (MC3T3-E1) were seeded and cultured within cylindrical type of IP-CHA block (ø 4x7 mm) by vacuum-assisted method. The IP-CHA/MC3T3 composites were subjected to FGF-2 and/or MEL. The proliferation assay, alkaline phosphatase enzyme activity (ALP), mRNA expressions of late bone markers, namely Osteocalcin (OCN) and Osteopontin (OPN), and Alizarin Red staining were examined over a period of 7 days. Results FGF-2 mainly enhanced the proliferation of MC3T3-E1 cells within the IP-CHA constructs. MEL mainly induced the mRNA expression of late bone markers (OCN and OPN) and showed increased ALP activity of MC3T3 cells cultured within IP-CHA construct. Moreover, the combination of FGF-2 and MEL showed increased osteogenic activity within the IP-CHA construct in terms of cell proliferation, upregulated expressions of OCN and OPN, increased ALP activity and mineralization with Alizarin Red. The synergy of the proliferative potential of FGF-2 and the differentiation potential of MEL showed increased osteogenic activity in MC3T3-E1 cells cultured within IP-CHA constructs. Conclusion These findings indicate that the combination of FGF-2 and MEL may be utilized with biocompatible materials to attain augmented osteogenic activity and mineralization.
Descritores: Osteoblastos/efeitos dos fármacos
Fator 2 de Crescimento de Fibroblastos/farmacologia
Durapatita/farmacologia
Substitutos Ósseos/farmacologia
Melatonina/farmacologia
-Fatores de Tempo
Teste de Materiais
Calcificação Fisiológica/efeitos dos fármacos
Microscopia Eletrônica de Varredura
Diferenciação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Reprodutibilidade dos Testes
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Proliferação Celular/efeitos dos fármacos
Fosfatase Alcalina/análise
Limites: Animais
Camundongos
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Ponzoni, Deise
Puricelli, Edela
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Id: lil-779902
Autor: ABREU, Maíra Cavallet de; PONZONI, Deise; LANGIE, Renan; ARTUZI, Felipe Ernesto; PURICELLI, Edela.
Título: Effects of a buried magnetic field on cranial bone reconstruction in rats
Fonte: J. appl. oral sci;24(2):162-170, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Projeto: Rio Grande do Sul Research Foundation.
Resumo: ABSTRACT The understanding of bone repair phenomena is a fundamental part of dentistry and maxillofacial surgery. Objective The present study aimed to evaluate the influence of buried magnetic field stimulation on bone repair in rat calvaria after reconstruction with autogenous bone grafts, synthetic powdered hydroxyapatite, or allogeneic cartilage grafts, with or without exposure to magnetic stimulation. Material and Methods Ninety male Wistar rats were divided into 18 groups of five animals each. Critical bone defects were created in the rats’ calvaria and immediately reconstructed with autogenous bone, powdered synthetic hydroxyapatite or allogeneic cartilage. Magnetic implants were also placed in half the animals. Rats were euthanized for analysis at 15, 30, and 60 postoperative days. Histomorphometric analyses of the quantity of bone repair were performed at all times. Results These analyses showed significant group by postoperative time interactions (p=0.008). Among the rats subjected to autogenous bone reconstruction, those exposed to magnetic stimulation had higher bone fill percentages than those without magnetic implants. Results also showed that the quality of bone repair remained higher in the former group as compared to the latter at 60 postoperative days. Conclusions After 60 postoperative days, bone repair was greater in the group treated with autogenous bone grafts and exposed to a magnetic field, and bone repair was most pronounced in animals treated with autogenous bone grafts, followed by those treated with powdered synthetic hydroxyapatite and allogeneic cartilage grafts.
Descritores: Regeneração Óssea/fisiologia
Transplante Ósseo/métodos
Terapia de Campo Magnético/métodos
Campos Magnéticos
-Crânio/cirurgia
Fatores de Tempo
Distribuição Aleatória
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Durapatita/uso terapêutico
Substitutos Ósseos/uso terapêutico
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Volpon, José Batista
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Id: lil-754991
Autor: Cimatti, Bruno; Engel, Edgard Eduard; Nogueira-Barbosa, Marcello Henrique; Frighetto, Paulo Donato; Volpon, José Batista.
Título: Physical and mechanical characterization of a porous cement for metaphyseal bone repair
Fonte: Acta ortop. bras;23(4):197-201, Jul-Aug/2015. tab, fig.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: OBJECTIVE: Macroporous cement with mechanical properties similar to cancellous bone may improve the treatment of large bone defects in relation to solid acrylic cement. The aim of this study was to compare physical and mechanical characteristics of a polymethyl methacrylate (PMMA) based porous cement with cancellous bone. METHODS: Compressive strength and pore size, interconnectivity, and distribution of cylindrical porous PMMA cement samples containing 10% (G1), 20% (G2) or 30% (G3) effervescent components were analyzed. Results were compared to bovine cancellous bone (G4) and solid PMMA (G5) samples. RESULTS: Scanning electron microscopy (SEM) of all experimental samples (G1 - G3) revealed a random distribution and a wide size variation of pores ranging from 50 µm to 3 mm. Micro-CT showed that G2 have high porosity and lower interconnectivity of pores. No significant differences in yield strength and Young's modulus were observed among G1, G2 and G3. G4 samples were slightly stronger and less elastic than the other groups. Solid PMMA is extremely strong and inelastic. CONCLUSIONS: PMMA based porous cement met the expected characteristics. High porosity with large and interconnected pores may allow for bone ingrowth. Strength and elasticity similar to cancellous bone may enhance mechanical stimuli to bone remodeling. Observational Descriptive Study.
Descritores: Cimentos para Ossos
Neoplasias Ósseas
Transplante Ósseo
Substitutos Ósseos
Polimetil Metacrilato
Responsável: BR1.1 - BIREME


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Id: biblio-954243
Autor: Cantín, Mario; Olate, Sergio; Sol, Mariano del.
Título: Mandibular trabecular structures in alveolar ridge preservation using different grafting materials after tooth extraction / Estructura trabecular mandibular en preservación de reborde alveolar utilizando diferentes materiales de injerto después de la exodoncia
Fonte: Int. j. morphol;36(3):1143-1148, Sept. 2018. tab, graf.
Idioma: en.
Projeto: Universidad de La Frontera.
Resumo: The aim was to describe the star volume analysis in ridge preservation using different grafting materials. Bilateral extraction of the first mandibular molars of sixteen male rabbits was performed, divided at random into four groups (n= 4 in each group) according to graft, using: blood clot (G1), xenograft (G2), pure phase beta-tricalcium phosphate (G3) and biphasic calcium phosphate (60 % HA / 40 % beta-TCP) (G4). Rabbits were euthanized at 4, 6, or 8 wk post-extraction; the trabecular bone structures was evaluated by star volume analysis. The Levene test was used to analyze variance, as was the independent sample t-test. A P-value of < 0.001 was used to establish a statistically significant. The star volume analysis of the mandibular trabecula shows that the marrow space star volume (V*m.space) was higher than the trabecular star volume (V*tr). At 6-week post-extraction, new trabecular bone was evident. At 8-week post-extraction V*tr increase in all groups and the V*m.space diminish, suggesting coarsening of the internal architecture. In G2, some trabecular bone was observed in the central region. In G3, most of the socket regions were occupied by newly formed and loose trabecular bone and in the G4, the sockets were almost entirely filled with trabecular bone. Star volume analysis is adequate to analysis of bone patterns formation using bone substitutes.

El objetivo de esta investigación fue describir el volumen estrella en preservación alveolar utilizando diferentes injertos óseos. La exodoncia bilateral del primer molar mandibular de 16 conejos machos fue realizada, dividiéndolos en 4 grupos (n= 4 en cada grupo) de acuerdo al injerto utilizado, siendo: coágulo sanguíneo (G1), xenoinjerto (G2), beta-tricalcio fosfato puro (G3) y fosfato de calcio bifásico (60 % HA / 40 % beta-TCP) (G4). Los conejos fueron sometidos a eutanasia a las 4, 6 u 8 semanas post exodoncia; el trabeculado óseo fue evaluado por medio del volumen estrella. La prueba de Levene fue utilizado para el análisis de varianza y luego la prueba t-test para muestras independientes. El valor de P menor a 0.001 fue establecido como significancia estadística. El análisis del volumen estrella del trabeculado mostró que el espacio medular de volumen estrella (V*m.space) fue mayor que trabeculado (V*tr). A 6 semanas post exodoncia, nuevo trabeculado óseo fue evidente. A las 8 semanas post exodoncia V*tr aumenta en todos los grupos y el V*m.space disminuye, sugiriendo un engrosamiento de la arquitectura interna. En el grupo G2, algún trabeculado óseo fue observado en la región central. En el G3, la mayoría del alveolo fue ocupado por nuevo hueso y perdió trabeculado óseo y en G4, el alveolo fue ocupado casi enteramente por hueso trabecular. El análisis de volumen estrella es adecuado para analizar el modelo de formación ósea utilizando sustitutos óseos.
Descritores: Transplante Ósseo/métodos
Alvéolo Dental/anatomia & histologia
Alvéolo Dental/cirurgia
Aumento do Rebordo Alveolar
-Extração Dentária
Cicatrização
Substitutos Ósseos
Mandíbula/anatomia & histologia
Limites: Animais
Coelhos
Responsável: CL1.1 - Biblioteca Central



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