Base de dados : LILACS
Pesquisa : D26.310 [Categoria DeCS]
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Id: biblio-1011088
Autor: Arnone, Marcelo; Takahashi, Maria Denise Fonseca; Carvalho, André Vicente Esteves de; Bernardo, Wanderley Marques; Bressan, Aline Lopes; Ramos, Andrea Machado Coelho; Terena, Aripuanã Cobério; Souza, Cacilda da Silva; Nunes, Daniel Holthausen; Bortoletto, Maria Cecília de Carvalho; Oliveira, Maria de Fátima Santos Paim de; Neffá, Jane Marcy; Fieri, Luciana Cristina; Azulay-Abulafia, Luna; Felix, Paulo Antônio Oldani; Magalhaes, Renata Ferreira; Romiti, Ricardo; Jaime, Tatiana Jerez.
Título: Diagnostic and therapeutic guidelines for plaque psoriasis - Brazilian Society of Dermatology
Fonte: An. bras. dermatol;94(2,supl.1):76-107, Mar.-Apr. 2019. tab, graf.
Idioma: en.
Resumo: Abstract: Psoriasis is a chronic inflammatory disease that affects 1.3% of the Brazilian population. The most common clinical manifestations are erythematous, scaling lesions that affect both genders and can occur on any anatomical site, preferentially involving the knees, elbows, scalp and genitals. Besides the impact on the quality of life, the systemic nature of the disease makes psoriasis an independent risk factor for cardiovascular disease, especially in young patients with severe disease. By an initiative of the Brazilian Society of Dermatology, dermatologists with renowned clinical experience in the management of psoriasis were invited to form a work group that, in a partnership with the Brazilian Medical Association, dedicated themselves to create the Plaque Psoriasis Diagnostic and Treatment Guidelines. The relevant issues for the diagnosis (evaluation of severity and comorbidities) and treatment of plaque psoriasis were defined. The issues generated a search strategy in the Medline-PubMed database up to July 2018. Subsequently, the answers to the questions of the recommendations were devised, and each reference selected presented the respective level of recommendation and strength of scientific evidence. The final recommendations for making up the final text were worded by the coordinators.
Descritores: Psoríase/diagnóstico
Psoríase/terapia
-Fototerapia/métodos
Psoríase/epidemiologia
Sociedades Médicas
Fatores de Tempo
Vitamina D/análise
Índice de Gravidade de Doença
Brasil
Comorbidade
Antralina/uso terapêutico
Metotrexato/uso terapêutico
Ciclosporina/uso terapêutico
Corticosteroides/uso terapêutico
Fármacos Dermatológicos/uso terapêutico
Dermatologia
Combinação de Medicamentos
Inibidores de Calcineurina/uso terapêutico
Anticorpos Monoclonais/uso terapêutico
Limites: Seres Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


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Id: lil-781364
Autor: Kontochristopoulos, George; Kouris, Anargyros; Chantzaras, Athanasios; Petridis, Athanasios; Yfantopoulos, John.
Título: Improvement of health-related quality of life and adherence to treatment with calcipotriol-betamethasone dipropionate gel in patients with psoriasis vulgaris
Fonte: An. bras. dermatol;91(2):160-166, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: Abstract BACKGROUND: Psoriasis is a common, chronic, recurrent, immune-mediated disorder of the skin and joints. It can have a significant negative impact on the physical, emotional and psychosocial wellbeing of affected patients. OBJECTIVES: To measure improvement in health-related QoL (HRQoL) in Greek patients with psoriasis vulgaris after a month of treatment with calcipotriol-betamethasone dipropionate gel; and evaluate adherence to treatment parameters. METHODS: The study included 394 psoriasis vulgaris patients from 16 private dermatological practices in Greece, all treated with calcipotriol-betamethasone dipropionate gel. They were evaluated at the first visit and after 4 weeks. Moreover, they completed the Dermatology Life Quality Index (DLQI), while other data such as disease severity, subjective symptoms and adherence, were collected. RESULTS: At week 4, the DLQI median was reduced by 3.5 points from the baseline (p<0.001; baseline and week 4 median: 4.5 and 1.0 respectively). Pruritus and sleep disorders also improved (p<0.001). Furthermore, 90.1% of the subjects fully adhered to treatment, with a 97.1% mean level of compliance. CONCLUSIONS: The convincing clinical results, with a distinct improvement in HRQoL, plus the high level of adherence due to its advantageous physical properties, make the calcipotriol-betamethasone dipropionate gel formulation an important, effective and well-tolerated topical therapy to treat psoriasis.
Descritores: Psoríase/tratamento farmacológico
Qualidade de Vida
Calcitriol/análogos & derivados
Betametasona/análogos & derivados
Fármacos Dermatológicos/uso terapêutico
Adesão à Medicação/estatística & dados numéricos
-Psoríase/patologia
Fatores de Tempo
Índice de Gravidade de Doença
Calcitriol/uso terapêutico
Betametasona/uso terapêutico
Estudos Prospectivos
Inquéritos e Questionários
Resultado do Tratamento
Estatísticas não Paramétricas
Combinação de Medicamentos
Adesão à Medicação/psicologia
Géis
Grécia
Limites: Seres Humanos
Masculino
Feminino
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Tipo de Publ: Estudo Multicêntrico
Responsável: BR1.1 - BIREME


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Id: biblio-839364
Autor: Lima, Glaura C; Silva, Emilia V; Magalhães, Pérola de O; Naves, Janeth S.
Título: Efficacy and safety of a four-drug fixed-dose combination regimen versus separate drugs for treatment of pulmonary tuberculosis: a systematic review and meta-analysis
Fonte: Braz. j. microbiol;48(2):198-207, April.-June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Introduction: Tuberculosis, particularly multi-drug-resistant tuberculosis, is a major cause of morbidity and mortality worldwide. To the best of our knowledge, however, no study to date has assessed the combined use of the four available drugs for tuberculosis treatment, which is an issue of great clinical relevance. Objective: To determine whether the four-drug fixed-dose combination is safer or more effective than separate drugs for treatment of pulmonary tuberculosis. Methods: A systematic review of the literature was performed in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Results: In pooled results from five randomized controlled trials with 3502 patients across Africa, Asia, and Latin America, four-drug fixed-dose combination therapy was no better than separate drugs therapy in terms of culture conversion after 2 and 6 months of treatment. There were no significant differences between the groups in overall incidence of adverse effects. However, the meta-analytic measure (log odds ratio) revealed that separate drugs treatment had a 1.65 [exp (0.5) = 1.65] increased chance of gastrointestinal adverse effects compared to four-drug fixed-dose combination treatment. Conclusions: The reviewed studies showed that four-drug fixed-dose combination therapy provides greater patient comfort by reducing the number of pills and the incidence of gastrointestinal adverse effects, as well as simplifying pharmaceutical management at all levels.
Descritores: Tuberculose Pulmonar/tratamento farmacológico
Antituberculosos/efeitos adversos
Antituberculosos/uso terapêutico
-Américas
Ensaios Clínicos Controlados Aleatórios como Assunto
Resultado do Tratamento
África
Combinação de Medicamentos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/patologia
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia
América Latina
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Amorim, Rosa Beatriz
Carvalho, Lidia Raquel de
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Id: lil-795999
Autor: Ramalho, Gualter Lisboa; Vane, Matheus Fachini; Lima, Luciana Cavalcanti; Vane, Lucas Fachini; Amorim, Rosa Beatriz; Domingues, Maria Aparecida; Moraes, José Mariano Soares de; Carvalho, Lídia Raquel de; Tanaka, Pedro Paulo; Vane, Luiz Antonio.
Título: Noradrenaline and dobutamine effects on the volume expansion with normal saline in rabbits subjected to hemorrhage
Fonte: Acta cir. bras;31(9):621-628, Sept. 2016. graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effects of dobutamine (DB), noradrenaline (NA), and their combination (NADB), on volume retention in rabbits submitted to hemorrhage. METHODS: Thirty six rabbits were randomly divided into 6 groups: SHAM, Control, Saline, DB, NA, DB+NA. All the animals, except for SHAM, were subjected to hemorrhage of 25% of the calculated blood volume. Control animals were replaced with their own blood. The other groups received NSS 3 times the volume withdrawn. The intravascular retention, hematocrit, diuresis, central venous pressure, mean arterial pressure, NGAL, dry-to-wet lung weight ratio (DTWR) and the lung and kidney histology were analyzed. RESULTS: Replacement with NSS and NA, DB or NA+DB did not produce differences in the intravascular retention. After hemorrhage, the animals presented a significant decrease in the MAP and CVP, which were maintained until volume replacement. Regarding NGAL, dry-to-wet-lung-weight ratio, lung and kidney histology, there were no statistical differences between the groups. CONCLUSION: The use of noradrenaline, dobutamine or their combination did not increase the intravascular retention of volume after normal saline infusion.
Descritores: Volume Sanguíneo/efeitos dos fármacos
Cloreto de Sódio/administração & dosagem
Norepinefrina/administração & dosagem
Agonistas Adrenérgicos beta/administração & dosagem
Dobutamina/administração & dosagem
Hemorragia/fisiopatologia
-Fatores de Tempo
Infusões Intravenosas
Distribuição Aleatória
Combinação de Medicamentos
Hematócrito
Rim/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Limites: Animais
Coelhos
Responsável: BR1.1 - BIREME


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Id: lil-785019
Autor: Silva, Sérgio Ribeiro da; Silva Neto, José Dias da; Schnaider, Taylor Brandão; Veiga, Daniela Francescato; Novo, Neil Ferreira; Mesquita Filho, Marcos; Ferreira, Lydia Masako.
Título: The use of a biocompatible cement in endodontic surgery. A randomized clinical trial 1
Fonte: Acta cir. bras;31(6):422-427graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the clinical applicability of Pozzolana Biologic Silva cement (PBS(r)) in endodontic surgery. METHODS: Persistent apical periodontitis was diagnosed in 30 teeth of 12 patients by cone-beam computed tomography (CT). All patients had 2 or 4 affected teeth and underwent endodontic surgery with root-end filling. Patients with 2 affected teeth had one tooth (control) treated with mineral trioxide aggregate (MTA-Angelus(r)) as a root-end filling material, and the other tooth treated with PBS (experiment). When the patient had four affected teeth, two of them were treated with MTA and two with PBS. Six months after surgery, all patients were assessed by CT scan. Between-group comparisons of measurements were performed using the Wilcoxon test. RESULTS: Periradicular tissue regeneration was observed in all cases. Significant within-group differences in long axes of the lesion were found in the bucco-palatal direction (PBS group, p=0.0012; MTA group, p=0.024) and coronal-apical direction (PBS group, p=0.0007; MTA group, p=0.0015) between pre- and postoperative measurements. CONCLUSIONS: Pozzolana Biologic Silva cement can be used in the treatment of persistent periradicular lesions. The clinical use of PBS as a root-end filling material may be an alternative to MTA. PBS has additives, which provide enhanced strength.
Descritores: Óxidos/uso terapêutico
Periodontite Periapical/cirurgia
Materiais Biocompatíveis/uso terapêutico
Compostos de Cálcio/uso terapêutico
Compostos de Alumínio/uso terapêutico
Cimentos Dentários/uso terapêutico
-Apicectomia/métodos
Periodontite Periapical/diagnóstico por imagem
Período Pós-Operatório
Regeneração/fisiologia
Raiz Dentária/cirurgia
Raiz Dentária/diagnóstico por imagem
Estudos Prospectivos
Combinação de Medicamentos
Tomografia Computadorizada de Feixe Cônico
Limites: Seres Humanos
Adolescente
Adulto
Meia-Idade
Adulto Jovem
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: lil-783795
Autor: Gandini, Marco; Cerri, Simona; Pregel, Paola; Giusto, Gessica; Vercelli, Cristina; Iussich, Selina; Tursi, Massimiliano; Farca, Anna Maria.
Título: Direct intraperitoneal resuscitation with lidocaine, methylene blue and pentoxiphylline combination does not decreases inflammation after intestinal ischemia-reperfusion injury in rats
Fonte: Acta cir. bras;31(5):333-337, May 2016. graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effects of an intraperitoneal solution of methylene blue (MB), lidocaine and pentoxyphylline (PTX) on intestinal ischemic and reperfusion injury METHODS: Superior mesenteric artery was isolated and clamped in 36 adult male Sprague Dawley rats. After 60 minutes, clamp was removed and a group received intraperitoneally UNITO solution (PTX 25mg/kg + lidocaine 5mg/kg + MB 2mg/kg), while the other group was treated with warm 0.9% NaCl solution. Rats were euthanized 45 min after drug administration. Lung and bowel were collected for histological evaluation (using Park's score) and determination of myeloperoxidase (MPO) and malondialdehyde (MDA) levels. RESULTS: Control samples showed lymphoplasmocytic infiltrate and crypt necrosis of villi. MPO and MDA measurements shown no differences between treated and control groups. CONCLUSION: The combination of lidocaine, methylene blue and pentoxyphylline administered intraperitoneally at the studied dose, did not decreased histological lesion scores and biochemical markers levels in intestinal ischemia/reperfusion injury.
Descritores: Pentoxifilina/uso terapêutico
Traumatismo por Reperfusão/tratamento farmacológico
Intestinos/irrigação sanguínea
Lidocaína/uso terapêutico
Azul de Metileno/uso terapêutico
Anti-Inflamatórios/uso terapêutico
-Pentoxifilina/administração & dosagem
Distribuição Aleatória
Peroxidase/metabolismo
Modelos Animais
Combinação de Medicamentos
Sinergismo Farmacológico
Inflamação/prevenção & controle
Inflamação/tratamento farmacológico
Infusões Parenterais
Intestinos/enzimologia
Lidocaína/administração & dosagem
Pulmão/irrigação sanguínea
Pulmão/metabolismo
Malondialdeído/metabolismo
Azul de Metileno/administração & dosagem
Anti-Inflamatórios/administração & dosagem
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-886229
Autor: Chen, Yunfeng; Zeng, Yiming; Zhang, Yin.
Título: A study on reducing the absorption of lidocaine from the airway in cats
Fonte: Acta cir. bras;32(8):662-672, Aug. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To determine if the combination of lidocaine with epinephrine or gamma globulin would decrease the rate or reduce the amount of local absorption of lidocaine through the airway. Methods: Twenty adult male cats were randomly and evenly distributed into four groups: 1) Group LG: lidocaine administered with gamma globulin; 2) Group LS: lidocaine administered with physiological saline); 3) Group LE: lidocaine administered with epinephrine; 4) Group C: control group. Invasive blood pressure, heart rate, and concentration of lidocaine were recorded before and after administration. Results: The peak of plasma concentrations appeared difference (Group LG: 1.39 ± 0.23 mg/L; Group LS: 1.47 ± 0.29 mg/L and Group LE: 0.99 ± 0.08 mg/L). Compared to Group C, there were significant differences in the average heart rate of Groups LG, LS, and LE (P < 0.05). The average systolic blood pressures were significantly different when each group was compared to Group C (P < 0.05). The biological half-life, AUC0-120, peak time, and half-life of absorption among the three groups have not presented statistically significant differences (P > 0.05). Conclusion: Administering lidocaine in combination with gamma globulin through airway causes significant decrease the rate and reduce the amount of local absorption of lidocaine in cats.
Descritores: gama-Globulinas/farmacocinética
Epinefrina/farmacocinética
Agonistas Adrenérgicos beta/farmacocinética
Absorção pelo Trato Respiratório/efeitos dos fármacos
Anestésicos Locais/farmacocinética
Lidocaína/farmacocinética
-Valores de Referência
Fatores de Tempo
Traqueia/efeitos dos fármacos
Pressão Sanguínea/efeitos dos fármacos
Broncoscopia/métodos
gama-Globulinas/administração & dosagem
Epinefrina/administração & dosagem
Distribuição Aleatória
Reprodutibilidade dos Testes
Agonistas Adrenérgicos beta/administração & dosagem
Combinação de Medicamentos
Frequência Cardíaca/efeitos dos fármacos
Anestésicos Locais/administração & dosagem
Anestésicos Locais/sangue
Lidocaína/administração & dosagem
Lidocaína/sangue
Limites: Animais
Masculino
Gatos
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-797977
Autor: Lei, Lei; Shao, Meiying; Yang, Yan; Mao, Mengying; Yang, Yingming; Hu, Tao.
Título: Exopolysaccharide dispelled by calcium hydroxide with volatile vehicles related to bactericidal effect for root canal medication
Fonte: J. appl. oral sci;24(5):487-495, Sept.-Oct. 2016. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: ABSTRACT Objective: Enterococcus faecalis is the dominant microbial species responsible for persistent apical periodontitis with ability to deeply penetrate into the dentin. Exopolysaccharides (EPS) contribute to the pathogenicity and antibiotic resistance of E. faecalis. Our aim was to investigate the antimicrobial activity of calcium hydroxide (CH), camphorated parachlorophenol (CMCP), and chlorhexidine (CHX) against E. faecalis in dentinal tubules. Material and Methods: Decoronated single-canal human teeth and semicylindrical dentin blocks were incubated with E. faecalis for 3 weeks. Samples were randomly assigned to six medication groups for 1 week (n=10 per group): CH + 40% glycerin-water solution (1:1, wt/vol); CMCP; 2% CHX; CH + CMCP (1:1, wt/vol); CH + CMCP (2:3, wt/vol); and saline. Bacterial samples were collected and assayed for colony-forming units. After dentin blocks were split longitudinally, confocal laser scanning microscopy was used to assess the proportion of viable bacteria and EPS production in dentin. Results: CMCP exhibited the best antimicrobial activity, while CH was the least sensitive against E. faecalis (p<0.05). CHX showed similar antimicrobial properties to CH + CMCP (1:1, wt/vol) (p>0.05). CH combined with CMCP inhibited EPS synthesis by E. faecalis, which sensitized biofilms to antibacterial substances. Moreover, increasing concentrations of CMCP decreased EPS matrix formation, which effectively sensitized biofilms to disinfection agents. Conclusion: The EPS matrix dispelled by CH paste with CMCP may be related to its bactericidal effect; the visualization and analysis of EPS formation and microbial colonization in dentin may be a useful approach to verify medicaments for antimicrobial therapy.
Descritores: Polissacarídeos Bacterianos/química
Irrigantes do Canal Radicular/farmacologia
Veículos Farmacêuticos/farmacologia
Hidróxido de Cálcio/farmacologia
Enterococcus faecalis/efeitos dos fármacos
Dentina/efeitos dos fármacos
Antibacterianos/farmacologia
-Fatores de Tempo
Cânfora/farmacologia
Contagem de Colônia Microbiana
Clorofenóis/farmacologia
Reprodutibilidade dos Testes
Estatísticas não Paramétricas
Microscopia Confocal
Biofilmes/efeitos dos fármacos
Cavidade Pulpar/efeitos dos fármacos
Cavidade Pulpar/microbiologia
Dentina/microbiologia
Combinação de Medicamentos
Viabilidade Microbiana/efeitos dos fármacos
Limites: Seres Humanos
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-787546
Autor: GUERREIRO-TANOMARU, Juliane Maria; VÁZQUEZ-GARCÍA, Fernando Antonio; BOSSO-MARTELO, Roberta; BERNARDI, Maria Inês Basso; FARIA, Gisele; TANOMARU FILHO, Mario.
Título: Effect of addition of nano-hydroxyapatite on physico-chemical and antibiofilm properties of calcium silicate cements
Fonte: J. appl. oral sci;24(3):204-210tab, graf.
Idioma: en.
Projeto: São Paulo Research Foundation; . São Paulo Research Foundation.
Resumo: ABSTRACT Objective Mineral Trioxide Aggregate (MTA) is a calcium silicate cement composed of Portland cement (PC) and bismuth oxide. Hydroxyapatite has been incorporated to enhance mechanical and biological properties of dental materials. This study evaluated physicochemical and mechanical properties and antibiofilm activity of MTA and PC associated with zirconium oxide (ZrO2) and hydroxyapatite nanoparticles (HAn). Material and Methods White MTA (Angelus, Brazil); PC (70%)+ZrO2 (30%); PC (60%)+ZrO2 (30%)+HAn (10%); PC (50%)+ZrO2 (30%)+HAn (20%) were evaluated. The pH was assessed by a digital pH-meter and solubility by mass loss. Setting time was evaluated by using Gilmore needles. Compressive strength was analyzed by mechanical test. Samples were radiographed alongside an aluminum step wedge to evaluate radiopacity. For the antibiofilm evaluation, materials were placed in direct contact with E. faecalis biofilm induced on dentine blocks. The number of colony-forming units (CFU mL-1) in the remaining biolfilm was evaluated. The results were submitted to ANOVA and the Tukey test, with 5% significance. Results There was no difference in pH levels of PC+ZrO2, PC+ZrO2+HAn (10%) and PC+ZrO2+HAn (20%) (p>0.05) and these cements presented higher pH levels than MTA (p<0.05). The highest solubility was observed in PC+ZrO2+HAn (10%) and PC+ZrO2+HAn (20%) (p<0.05). MTA had the shortest initial setting time (p<0.05). All the materials showed radiopacity higher than 3 mmAl. PC+ZrO2 and MTA had the highest compressive strength (p<0.05). Materials did not completely neutralize the bacterial biofilm, but the association with HAn provided greater bacterial reduction than MTA and PC+ZrO2 (p<0.05) after the post-manipulation period of 2 days. Conclusions The addition of HAn to PC associated with ZrO2 harmed the compressive strength and solubility. On the other hand, HAn did not change the pH and the initial setting time, but improved the radiopacity (HAn 10%), the final setting time and the E. faecalis antibiofilm activity of the cement.
Descritores: Óxidos/química
Zircônio/química
Enterococcus faecalis/efeitos dos fármacos
Silicatos/química
Durapatita/química
Compostos de Cálcio/química
Compostos de Alumínio/química
Biofilmes/efeitos dos fármacos
Nanopartículas/química
-Óxidos/farmacologia
Solubilidade
Fatores de Tempo
Zircônio/farmacologia
Bismuto/farmacologia
Bismuto/química
Teste de Materiais
Contagem de Colônia Microbiana
Análise de Variância
Enterococcus faecalis/crescimento & desenvolvimento
Silicatos/farmacologia
Durapatita/farmacologia
Compostos de Cálcio/farmacologia
Compostos de Alumínio/farmacologia
Força Compressiva
Cimentos Dentários/farmacologia
Cimentos Dentários/química
Combinação de Medicamentos
Concentração de Íons de Hidrogênio
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-951926
Autor: María, Espinosa Bosch; Fuensanta, Sánchez Rojas; Catalina, Bosch Ojeda.
Título: Determination of compatibility and stability of haloperidol and morphine mixtures used in palliative care
Fonte: Braz. J. Pharm. Sci. (Online);54(2):e17352, 2018. tab, graf.
Idioma: en.
Projeto: Consejería de Igualdad Salud y Políticas Sociales.
Resumo: Abstract With the aim of controlling various symptoms, possible to use mixtures of different drugs within infusion devices. This should take into account the compatibility of the mixture. Factors influence the compatibility and stability of the mixtures are: drug type, concentration, solvent, temperature and light. When evaluating the compatibility of the mixtures for infusion for subcutaneous via is important to consider infusion devices used and the conditions of light and temperature should simulate as far as possible the conditions in practice assistance. There are diverse studies that analyze the compatibility of drug mixtures, but there are still many possible combinations of drugs for which evidence is not available. The objective of this work is to study the compatibility and stability of several mixtures of haloperidol and morphine that can be used in solution for subcutaneous infusion.
Descritores: Haloperidol/análise
Morfina/análise
-Cuidados Paliativos/classificação
Combinação de Medicamentos
Estabilidade de Medicamentos
Responsável: BR1.1 - BIREME



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