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Pesquisa : D27.505.519.562.906 [Categoria DeCS]
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Texto completo SciELO Brasil
Colombari, E
Texto completo
Id: lil-512758
Autor: Ogihara, C. A; Schoorlemmer, G. H. M; Colombari, E; Sato, M. A.
Título: Changes in sodium appetite evoked by lesions of the commissural nucleus of the tractus solitarius
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;42(6):561-566, June 2009. ilus, graf.
Idioma: en.
Resumo: Ablation of the area postrema/caudal nucleus of the tractus solitarius (NTS) complex increases sodium intake, but the effect of selective lesions of the caudal NTS is not known. We measured depletion-induced sodium intake in rats with electrolytic lesions of the commissural NTS that spared the area postrema. One day after the lesion, rats were depleted of sodium with furosemide (10 mg/kg body weight, sc) and then had access to water and a sodium-deficient diet for 24 h when 1.8 percent NaCl was offered. Water and saline intakes were measured for 2 h. Saline intake was higher in lesioned than in sham-lesioned rats (mean ± SEM: 20 ± 2 vs 11 ± 3 mL/2 h, P < 0.05, N = 6-7). Saline intake remained elevated in lesioned rats when the tests were repeated 6 and 14 days after the lesion, and water intake in these two tests was increased as well. Water intake seemed to be secondary to saline intake both in lesioned and in sham-lesioned rats. A second group of rats was offered 10 percent sucrose for 2 h/day before and 2, 7, and 15 days after lesion. Sucrose intake in lesioned rats was higher than in sham-lesioned rats only 7 days after lesioning. A possible explanation for the increased saline intake in rats with commissural NTS lesions could be a reduced gastrointestinal feedback inhibition. The commissural NTS is probably part of a pathway for inhibitory control of sodium intake that also involves the area postrema and the parabrachial nucleus.
Descritores: Apetite/fisiologia
Ingestão de Líquidos/fisiologia
Cloreto de Sódio na Dieta/administração & dosagem
Núcleo Solitário/lesões
-Furosemida/farmacologia
Ratos Wistar
Inibidores de Simportadores de Cloreto de Sódio e Potássio/farmacologia
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-414720
Autor: Cavalcante-Lima, H. R; Badauê-Passos Júnior, D; De-lucca Júnior, W; Lima, H. R. C; Costa-e-Sousa, R. H; Olivares, E. L; Cedraz-Mercez, P. L; Reis, R. O; Medeiros, M. A; Côrtes, W. S; Reis, L. C.
Título: Chronic excitotoxic lesion of the dorsal raphe nucleus induces sodium appetite
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;38(11):1669-1675, Nov. 2005. ilus.
Idioma: en.
Projeto: Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro.
Resumo: We determined if the dorsal raphe nucleus (DRN) exerts tonic control of basal and stimulated sodium and water intake. Male Wistar rats weighing 300-350 g were microinjected with phosphate buffer (PB-DRN, N = 11) or 1 æg/0.2 æl, in a single dose, ibotenic acid (IBO-DRN, N = 9 to 10) through a guide cannula into the DRN and were observed for 21 days in order to measure basal sodium appetite and water intake and in the following situations: furosemide-induced sodium depletion (20 mg/kg, sc, 24 h before the experiment) and a low dose of dietary captopril (1 mg/g chow). From the 6th day after ibotenic acid injection IBO-DRN rats showed an increase in sodium appetite (12.0 ± 2.3 to 22.3 ± 4.6 ml 0.3 M NaCl intake) whereas PB-DRN did not exceed 2 ml (P < 0.001). Water intake was comparable in both groups. In addition to a higher dipsogenic response, sodium-depleted IBO-DRN animals displayed an increase of 0.3 M NaCl intake compared to PB-DRN (37.4 ± 3.8 vs 21.6 ± 3.9 ml 300 min after fluid offer, P < 0.001). Captopril added to chow caused an increase of 0.3 M NaCl intake during the first 2 days (IBO-DRN, 33.8 ± 4.3 and 32.5 ± 3.4 ml on day 1 and day 2, respectively, vs 20.2 ± 2.8 ml on day 0, P < 0.001). These data support the view that DRN, probably via ascending serotonergic system, tonically modulates sodium appetite under basal and sodium depletion conditions and/or after an increase in peripheral or brain angiotensin II.
Descritores: Ácido Ibotênico/toxicidade
Agonistas de Aminoácidos Excitatórios/toxicidade
Apetite/efeitos dos fármacos
Ingestão de Líquidos/efeitos dos fármacos
Núcleos da Rafe/efeitos dos fármacos
Sódio na Dieta
-Apetite/fisiologia
Tampões (Química)
Captopril/farmacologia
Furosemida/farmacologia
Ingestão de Líquidos/fisiologia
Inibidores da Enzima Conversora de Angiotensina/farmacologia
Inibidores de Simportadores de Cloreto de Sódio e Potássio/farmacologia
Fosfatos
Ratos Wistar
Fatores de Tempo
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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