Base de dados : LILACS
Pesquisa : D27.505.519.593.249.500 [Categoria DeCS]
Referências encontradas : 5 [refinar]
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Texto completo SciELO Brasil
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Id: biblio-844207
Autor: Madureira, Pedro; Rodrigues, Mariana; Serrano, Edite; Vítor, Artur Bonito; Brito, Iva.
Título: Intracardiac thrombosis in Behçet's disease: a life threatening event / Trombose intracardíaca na doença de Behçet: evento com risco de vida
Fonte: Rev. bras. reumatol;57(1):85-87, Jan.-Feb. 2017. graf.
Idioma: en.
Descritores: Embolia Pulmonar/diagnóstico por imagem
Trombose/diagnóstico por imagem
Síndrome da Veia Cava Superior/diagnóstico por imagem
Síndrome de Behçet/diagnóstico por imagem
Antibacterianos/uso terapêutico
Anticoagulantes/uso terapêutico
-Embolia Pulmonar/fisiopatologia
Embolia Pulmonar/tratamento farmacológico
Trombose/fisiopatologia
Trombose/tratamento farmacológico
Varfarina/uso terapêutico
Síndrome da Veia Cava Superior/fisiopatologia
Síndrome da Veia Cava Superior/tratamento farmacológico
Prednisolona/uso terapêutico
Diagnóstico por Imagem
Colchicina/análogos & derivados
Colchicina/uso terapêutico
Síndrome de Behçet/fisiopatologia
Síndrome de Behçet/tratamento farmacológico
Resultado do Tratamento
Moduladores de Tubulina/uso terapêutico
Limites: Humanos
Masculino
Adulto Jovem
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-889042
Autor: Freitas, SCMP; Tavares, ER; Silva, BMO; Meneghini, BC; Kalil-Filho, R; Maranhão, RC.
Título: Lipid core nanoparticles resembling low-density lipoprotein and regression of atherosclerotic lesions: effects of particle size
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(3):7090, 2018. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Particles are usually polydispersed and size is an important feature for lipid-based drug delivery systems in order to optimize cell-particle interactions as to pharmacologic action and toxicity. Lipid nanoparticles (LDE) with composition similar to that of low-density lipoprotein carrying paclitaxel were shown to markedly reduce atherosclerosis lesions induced in rabbits by cholesterol feeding. The aim of this study was to test whether two LDE fractions, one with small (20-60 nm) and the other with large (60-100 nm) particles, had different actions on the atherosclerotic lesions. The two LDE-paclitaxel fractions, prepared by microfluidization, were separated by density gradient ultracentrifugation and injected (4 mg/body weight, intravenously once a week) into two groups of rabbits previously fed cholesterol for 4 weeks. A group of cholesterol-fed animals injected with saline solution was used as control to assess lesion reduction with treatment. After the treatment period, the animals were euthanized for analysis. After treatment, both the small and large nanoparticle preparations of LDE-paclitaxel had equally strong anti-atherosclerosis action. Both reduced lesion extension in the aorta by roughly 50%, decreased the intima width by 75% and the macrophage presence in the intima by 50%. The two preparations also showed similar toxicity profile. In conclusion, within the 20-100 nm range, size is apparently not an important feature regarding the LDE nanoparticle system and perhaps other solid lipid-based systems.
Descritores: Paclitaxel/administração & dosagem
Aterosclerose/tratamento farmacológico
Moduladores de Tubulina/administração & dosagem
Nanopartículas/administração & dosagem
Lipídeos/administração & dosagem
Lipoproteínas LDL/efeitos dos fármacos
-Tamanho da Partícula
Quimioterapia Combinada
Limites: Animais
Masculino
Coelhos
Responsável: BR1.1 - BIREME


  3 / 5 LILACS  
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Maranhäo, Raul C
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Id: lil-794635
Autor: Shiozaki, Afonso A; Senra, Tiago; Morikawa, Aleksandra T; Deus, Débora F; Paladino-Filho, Antonio T; Pinto, Ibraim MF; Maranhão, Raul C.
Título: Treatment of patients with aortic atherosclerotic disease with paclitaxel-associated lipid nanoparticles
Fonte: Clinics;71(8):435-439, Aug. 2016. tab.
Idioma: en.
Resumo: OBJECTIVE: The toxicity of anti-cancer chemotherapeutic agents can be reduced by associating these compounds, such as the anti-proliferative agent paclitaxel, with a cholesterol-rich nanoemulsion (LDE) that mimics the lipid composition of low-density lipoprotein (LDL). When injected into circulation, the LDE concentrates the carried drugs in neoplastic tissues and atherosclerotic lesions. In rabbits, atherosclerotic lesion size was reduced by 65% following LDE-paclitaxel treatment. The current study aimed to test the effectiveness of LDE-paclitaxel on inpatients with aortic atherosclerosis. METHODS: This study tested a 175 mg/m2 body surface area dose of LDE-paclitaxel (intravenous administration, 3/3 weeks for 6 cycles) in patients with aortic atherosclerosis who were aged between 69 and 86 yrs. A control group of 9 untreated patients with aortic atherosclerosis (72-83 yrs) was also observed. RESULTS: The LDE-paclitaxel treatment elicited no important clinical or laboratory toxicities. Images were acquired via multiple detector computer tomography angiography (64-slice scanner) before treatment and at 1-2 months after treatment. The images showed that the mean plaque volume in the aortic artery wall was reduced in 4 of the 8 patients, while in 3 patients it remained unchanged and in one patient it increased. In the control group, images were acquired twice with an interval of 6-8 months. None of the patients in this group exhibited a reduction in plaque volume; in contrast, the plaque volume increased in three patients and remained stable in four patients. During the study period, one death unrelated to the treatment occurred in the LDE-paclitaxel group and one death occurred in the control group. CONCLUSION: Treatment with LDE-paclitaxel was tolerated by patients with cardiovascular disease and showed the potential to reduce atherosclerotic lesion size.
Descritores: Doenças da Aorta/tratamento farmacológico
Colesterol/uso terapêutico
Paclitaxel/uso terapêutico
Aterosclerose/tratamento farmacológico
Moduladores de Tubulina/uso terapêutico
Nanopartículas/uso terapêutico
-Aorta Torácica/efeitos dos fármacos
Doenças da Aorta/diagnóstico por imagem
Fatores de Tempo
Triglicerídeos/sangue
Angiografia
Colesterol/sangue
Reprodutibilidade dos Testes
Resultado do Tratamento
Sistemas de Liberação de Medicamentos
Aterosclerose/diagnóstico por imagem
Emulsões Gordurosas Intravenosas/uso terapêutico
Tomografia Computadorizada Multidetectores
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Ensaio Clínico Controlado
Responsável: BR1.1 - BIREME


  4 / 5 LILACS  
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Id: lil-772151
Autor: Monteiro, Mariana Raquel; Kandratavicius, Ludmyla; Peixoto-Santos, Jose Eduardo; Scandiuzzi, Renata Caldo; Carlotti Júnior, Carlos Gilberto; Assirati Júnior, João Alberto; Leite, João Pereira.
Título: Beta-tubulin expression In the hippocampus Of patients with mesial temporal lobe epilepsy / Expressão de beta-tubulina no hipocampo de pacientes com epilepsia do lobo temporal mesial / Expresión de beta-tubulina en el hipocampo de los pacientes con epilepsia del lóbulo temporal mesial
Fonte: J. epilepsy clin. neurophysiol;21(3), set. 2015. ilus, tab.
Idioma: pt.
Resumo: Introduction: The neuronal loss and abnormal mossy fibers sprouting are frequently observed in patients with mesial temporal lobe epilepsy (MTLE). Beta-tubulin, a cytoskeleton protein, is critical for the maintenance of the neuritic structure. Objective: Considering the axonal reorganization in patients with MTLE, our objective was to analyze the beta-tubulin expression in the hippocampus of these patients. Methods: We evaluated the hippocampus of 38 MTLE patients and seven control cases. Histological sections were submitted to neo-Timm histochemistry to evaluate the sprouting of mossy fiber, and to immunohis- tochemistry for neuronal density evaluation (NeuN) and beta-tubulin expression. Results: The MTLE group showed lower neuronal density than the control group in the granular layer (GL), hilus, CA4, CA3, CA1, and presubiculum. The MTLE group showed higher gray value on the neo-Timm staining when compared to the control group in GL, IML, and outer mo- lecular layer (OML), and sprouting of thicker mossy fibers in the IML. When compared to the control group, group MTLE showed higher beta-tubulin expression in GL and lower expression in CA3 region. The aberrant sprouting of mossy fibers correlated inversely with the beta-tubulin expression in several subs of the hippocampal formation. Conclusions: The differential expression of beta-tubulin in the regions CA3 and GL of the MTLE group, as well as its correlation with neuronal loss and the mossy fiber sprouting, suggests a possible role of this protein in the neuropathological changes that occur in the hippocampus in chronic cases of MTLE.

Introdução: A perda neuronal e o brotamento anormal de fibras musgosas são observados com frequência em pacientes com epilepsia do lobo temporal mesial (ELTM). A beta-tubulina, uma proteína do citoesqueleto, é essencial para a manutenção da estrutura neurítica. Objetivo: Considerando a reorganização axonal nos pacientes com ELTM, nosso objetivo foi analisar a expressão de beta-tubulina no hipo- campo desses pacientes. Métodos: Foram avaliados 38 hipocampos de pacientes com ELTM e sete casos controle. Cortes histológicos foram submetidos à histoquímica de neo-Timm para avaliação do neobrotamento de fibras musgosas e à imuno-histoquímica para avaliações da densidade neuronal (NeuN) e da expressão de beta-tubulina. Resultados: O grupo ELTM apresentou menor densidade neuronal do que o grupo controle na camada granular (CG), hilo, CA4, CA3, CA1 e no pró-subículo. O grupo ELTM apresentou maior valor de cinza na coloração neo-Timm com relação ao grupo controle na CG, CMI e camada molecular externa (CME) e neobrotamento mais espesso de fibras musgosas na CMI. O grupo ELTM apresentou maior expressão de beta-tubulina na CG e menor expressão na região de CA3, quando comparado ao grupo controle. O neobrotamento aberrante de fibras musgosas correlacionou-se inversamente com a expressão de beta-tubulina em diversos subcampos da formação hipocampal. Conclusões: A expressão diferencial da beta-tubulina nas regiões da CA3 e CG do grupo ELTM, assim como suas correlações com a perda neuronal e o neobrotamento de fibras musgosas sugerem uma possível participação dessa proteína nas alterações neuropatológicas que ocorrem no hipocampo nos casos crônicos de ELTM.

Introducción: La pérdida neuronal y la brotación anormal de fibras musgosas se observan con frecuencia en los pacientes con epilepsia del lóbulo temporal mesial (ELTM). La beta-tubulina, una proteína del citoesqueleto, es crítica para el mantenimiento de la estructura neurítica. Objetivo: Teniendo en cuenta la reorganización axonal en pacientes con ELTM, nuestro objetivo fue analizar la expresión de beta-tubulina en el hipocampo de estos pacientes. Métodos: Se evaluó el hipocampo de 38 pacientes con ELTM y siete casos de control. Cortes histológicos fueron sometidos a la histoquímica neo-Timm para evaluar la brotación de fibras musgosas, y a inmunohistoquímica para la evaluación de la densidad neuronal (NeuN) y la expresión de beta-tubulina. Resultados: El grupo ELTM mostró una menor densidad neuronal que el grupo control en la capa granular (CG), hilo, CA4, CA3, CA1 y pró-subículo. El grupo ELTM mostró mayor valor de gris en la tinción neo-Timm en comparación con el grupo control en CG, CMI y en la capa externa molecular (CME), y la brotación de fibras musgosas más gruesas en la CMI. El grupo ELTM mostró una mayor expresión de beta- tubulina en CG y expresión más baja en la región CA3, cuando se compara con el grupo control. La brotación aberrante de fibras musgosa está inversamente correlacionada con la expresión de beta-tubulina en varios subcampos de la formación del hipocampo. Conclusiones: La expresión diferencial de beta-tubulina en las regiones CA3 y CG del grupo ELTM, así como su correlación con la pérdida neuronal y el surgimiento de fibras musgosas, sugiere un posible papel de esta proteína en los cambios neuropatológicos que se producen en el hipocampo en los casos crónicos de ELTM.
Descritores: Citoesqueleto
Epilepsia
Hipocampo
Moduladores de Tubulina
Limites: Humanos
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: lil-666049
Autor: Dagger, Francehuli; Valdivieso, Elizabeth; Marcano, Ana K; Ayesta, Carlos.
Título: Regulatory volume decrease in Leishmania mexicana: effect of anti-microtubule drugs
Fonte: Mem. Inst. Oswaldo Cruz;108(1):84-90, Feb. 2013. ilus, graf, tab.
Idioma: en.
Projeto: FONACIT.
Resumo: The trypanosomatid cytoskeleton is responsible for the parasite's shape and it is modulated throughout the different stages of the parasite's life cycle. When parasites are exposed to media with reduced osmolarity, they initially swell, but subsequently undergo compensatory shrinking referred to as regulatory volume decrease (RVD). We studied the effects of anti-microtubule (Mt) drugs on the proliferation of Leishmania mexicana promastigotes and their capacity to undergo RVD. All of the drugs tested exerted antiproliferative effects of varying magnitudes [ansamitocin P3 (AP3)> trifluoperazine > taxol > rhizoxin > chlorpromazine]. No direct relationship was found between antiproliferative drug treatment and RVD. Similarly, Mt stability was not affected by drug treatment. Ansamitocin P3, which is effective at nanomolar concentrations, blocked amastigote-promastigote differentiation and was the only drug that impeded RVD, as measured by light dispersion. AP3 induced 2 kinetoplasts (Kt) 1 nucleus cells that had numerous flagella-associated Kts throughout the cell. These results suggest that the dramatic morphological changes induced by AP3 alter the spatial organisation and directionality of the Mts that are necessary for the parasite's hypotonic stress-induced shape change, as well as its recovery.
Descritores: Citoesqueleto/efeitos dos fármacos
Leishmania mexicana/efeitos dos fármacos
Moduladores de Tubulina/farmacologia
-Clorpromazina/farmacologia
Leishmania mexicana/crescimento & desenvolvimento
Macrolídeos/farmacologia
Maitansina/análogos & derivados
Maitansina/farmacologia
Paclitaxel/farmacologia
Trifluoperazina/farmacologia
Limites: Animais
Camundongos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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