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Id: biblio-841153
Autor: ZHOU, Yang; LONG, Hu; YE, Niansong; LIAO, Lina; YANG, Xin; JIAN, Fan; WANG, Yan; LAI, Wenli.
Título: The effect of capsaicin on expression patterns of CGRP in trigeminal ganglion and trigeminal nucleus caudalis following experimental tooth movement in rats
Fonte: J. appl. oral sci;24(6):597-606, Nov.-Dec. 2016. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . National Natural Science Foundation of China; . National Natural Science Foundation of China.
Resumo: ABSTRACT Objectives The aim of this study was to explore the effect of capsaicin on expression patterns of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) and trigeminal subnucleus caudalis (Vc) following experimental tooth movement. Material and Methods Male Sprague-Dawley rats were used in this study and divided into small-dose capsaicin+force group, large-dose capsaicin+force group, saline+force group, and no force group. Closed coil springs were used to mimic orthodontic forces in all groups except for the no force group, in which springs were inactivated. Capsaicin and saline were injected into periodontal tissues. Rats were euthanized at 0 h, 12 h, 1 d, 3 d, 5 d, and 7 d following experimental tooth movement. Then, TG and Vc were obtained for immunohistochemical staining and western blotting against CGRP. Results Immunohistochemical results indicated that CGRP positive neurons were located in the TG, and CGRP immunoreactive fibers were distributed in the Vc. Immunohistochemical semiquantitative analysis and western blotting analysis demonstrated that CGRP expression levels both in TG and Vc were elevated at 12 h, 1 d, 3 d, 5 d, and 7 d in the saline + force group. However, both small-dose and large-dose capsaicin could decrease CGRP expression in TG and Vc at 1 d and 3 d following experimental tooth movement, as compared with the saline + force group. Conclusions These results suggest that capsaicin could regulate CGRP expression in TG and Vc following experimental tooth movement in rats.
Descritores: Técnicas de Movimentação Dentária/métodos
Núcleo Inferior Caudal do Nervo Trigêmeo/efeitos dos fármacos
Capsaicina/farmacologia
Peptídeo Relacionado com Gene de Calcitonina/efeitos dos fármacos
Gânglio Trigeminal/efeitos dos fármacos
Fármacos do Sistema Sensorial/farmacologia
-Valores de Referência
Fatores de Tempo
Núcleo Inferior Caudal do Nervo Trigêmeo/química
Dor Facial
Imuno-Histoquímica
Cloreto de Sódio
Distribuição Aleatória
Peptídeo Relacionado com Gene de Calcitonina/análise
Western Blotting
Gânglio Trigeminal/química
Reprodutibilidade dos Testes
Ratos Sprague-Dawley
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME



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