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Pesquisa : D27.505.696.706 [Categoria DeCS]
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Id: biblio-1001146
Autor: Ermis, Esra; Celik, Sevim Karakas; Solak, Nilgun; Genc, Gunes Cakmak; Dursun, Ahmet.
Título: The role of GNLY gene polymorphisms in psoriasis pathogenesis
Fonte: An. bras. dermatol;94(2):198-203, Mar.-Apr. 2019. tab, graf.
Idioma: en.
Projeto: Unit of Scientific Research Projects of Bulent Ecevit University.
Resumo: Abstract BACKGROUND: Psoriasis is a systemic inflammatory disorder that involves complex pathogenic interactions between the innate and adaptive immune systems. The most accepted mechanism in the etiopathogenesis of psoriasis is the induction of inflammation with keratinocyte hyperproliferation. Granulysin (GNLY) is a cytolytic antimicrobial peptide (AMP) that is secreted together with granzyme and perforin from the granules of human cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. It has been immunohistochemically proven that the expression of granulysin is increased in lesions of psoriasis. OBJECTIVE: This study aimed to investigate the relationship between psoriasis disease and granulysin gene polymorphisms. METHODS: GNLY rs7908 and rs10180391 polymorphisms were studied by PCR-RFLP in 100 psoriasis patients under treatment in the Dermatology Polyclinic of Bulent Ecevit University. In addition, 100 healthy individuals with similar age and sex distribution were used as a control group. RESULTS: In the control group, GNLY rs7908 CC genotype was significantly higher than in psoriasis patients (P= 0.031; OR= 0.305; Cl= 0.305 (0.121 - 0.773). In our study, the genotype distributions in patients and control groups were GNLY rs7908 (SNP) GG (51%, 37%), GC (41%, 44%), CC (8%, 19%); GNLY rs10180391 (SNP) from the CC (41%, 44%), CT (42%, % 41), TT (17%, 15%). STUDY LIMITATIONS: The study only included Turkish patients. CONCLUSION: Our findings showed that GNLY rs7908 CC genotype and C allele had a protective effect against psoriasis and decreased the disease severity (according to PASI score), whereas rs10180391 SNP did not show any effective role in psoriasis pathogenesis.
Descritores: Polimorfismo Genético/genética
Psoríase/genética
Antígenos de Diferenciação de Linfócitos T/genética
-Psoríase/etiologia
Índice de Gravidade de Doença
Estudos de Casos e Controles
Expressão Gênica
Substâncias Protetoras
Alelos
Genótipo
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-837659
Autor: Onalan, Ali Kemal; Tuncal, Salih; Kilicoglu, Sibel; Celepli, Salih; Durak, Esra; Kilicoglu, Bulent; Devrim, Erdinc; Barlas, Aziz Mutlu; Kismet, Kemal.
Título: Effect of silymarin on oxidative stress and liver histopathology in experimental obstructive jaundice model
Fonte: Acta cir. bras;31(12):801-806, Dec. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the effect of silymarin on oxidative stress and hepatic injury induced by obstructive jaundice in an experimental model. METHODS: Thirty Wistar-Albino type female rats were divided into 3 groups each including 10 rats. Only laparotomy was performed in group 1. Bile duct ligation was performed in group 2. In group 3, bile duct ligation was performed and orogastic silymarin 300 mg/kg/day dose was given for seven days. At the end of seven days, rats were sacrificed. The blood and liver tissue samples were taken to be examined biochemically and histopathologically. RESULTS: The plasma and liver levels of malondialdehyde were significantly lower in silymarin group than in the bile duct ligated group. Although liver levels of GSH were significantly higher in silymarin group than in the bile duct ligated group, there was no significant difference between the plasma GSH levels of these groups. In silymarin group; the enlargement of hepatocytes, dilatation of canaliculi and the edema were regressed. CONCLUSION: Silymarin diminished the harmful effects of obstructive jaundice on liver.
Descritores: Silimarina/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Icterícia Obstrutiva/complicações
Fígado/patologia
Antioxidantes/farmacologia
-Ductos Biliares
Distribuição Aleatória
Ratos Wistar
Substâncias Protetoras/farmacologia
Icterícia Obstrutiva/patologia
Glutationa/sangue
Ligadura
Malondialdeído/sangue
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: lil-785016
Autor: Asghari, Ahmad; Akbari, Ghasem; Meghdadi, Afshin; Mortazavi, Pejman.
Título: Protective effect of metformin on testicular ischemia/reperfusion injury in rats
Fonte: Acta cir. bras;31(6):411-416tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the protective effect of metformin on testicular ischemia/reperfusion (I/R) injury in rats. METHODS: Eighteen adult male Wistar rats were randomly divided into three experimental groups (n=6), as follows: Sham, I/R, and Metformin. 1-hour ischemia was induced by the left testicular artery and vein clipping followed by 7 days of reperfusion. Metformin (100 mg/kg) was administrated orally for 7 days via oral gavage after ischemic period. At the end of trial, the left testis was removed for histological analysis and oxidative stress measurement. RESULTS: I/R reduced superoxide dismutase (SOD) activities and testicular Johnsen's scores accompanied by an elevation in malondialdehyde (MDA) and myeloperoxidase (MPO) levels in comparison with the sham group (P < 0.05). Compared to I/R group, metformin restored testicular Johnsen's scores, SOD activity, MDA and MPO levels (P < 0.05). CONCLUSION: Metformin has a protective effect against I/R injury on the testis.
Descritores: Testículo/irrigação sanguínea
Traumatismo por Reperfusão/prevenção & controle
Substâncias Protetoras/farmacologia
Metformina/farmacologia
-Superóxido Dismutase/metabolismo
Testículo/metabolismo
Traumatismo por Reperfusão/metabolismo
Distribuição Aleatória
Ratos Wistar
Peroxidase/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais
Malondialdeído/metabolismo
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-777094
Autor: Zhou, Jiang-qiao; Qiu, Tao; Zhang, Lu; Chen, Zhong-bao; Wang, Zhi-shun; Ma, Xiao-xiong; Li, Dongyu.
Título: Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model
Fonte: Acta cir. bras;31(3):176-182, Mar. 2016. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Hubei Natural Science Foundation; . bureau of public health of Hubei Province; . Wuhan Municipal Science and Technology Bureau.
Resumo: ABSTRACT PURPOSE: To investigate the potential effects of pretreatment with allopurinol on renal ischemia/reperfusion injury (IRI) in a rat model. METHODS: Twenty four rats were subjected to right kidney uninephrectomy were randomly distributed into the following three groups (n=8): Group A (sham-operated group); Group B (ischemic group) with 30 min of renal ischemia after surgery; and Group C (allopurinol + ischemia group) pretreated with allopurinol at 50 mg/kg for 14 days. At 72 h after renal reperfusion, the kidney was harvested to assess inflammation and apoptosis. RESULTS: Pretreatment with allopurinol significantly improved renal functional and histological grade scores following I/R injury (p<0.05). Compared with Group B, the expression levels of caspase-3 and Bax were markedly reduced in Group C, meanwhile, whereas expression of bcl-2 was clearly increased (p<0.05). A newly described marker of inflammation, High Mobility Group Box 1(HMGB1), showed reduced expression in Group C (p<0.05). CONCLUSION: Pretreatment with allopurinol had a protective effect on kidney ischemia/reperfusion injury, which might be related to the inhibition of HMGB1 expression.
Descritores: Traumatismo por Reperfusão/prevenção & controle
Alopurinol/farmacologia
Precondicionamento Isquêmico/métodos
Substâncias Protetoras/farmacologia
Proteína HMGB1/efeitos dos fármacos
Rim/irrigação sanguínea
-Superóxido Dismutase/efeitos dos fármacos
Nitrogênio da Ureia Sanguínea
Traumatismo por Reperfusão/metabolismo
Distribuição Aleatória
Ratos Sprague-Dawley
Apoptose/efeitos dos fármacos
Peroxidase/metabolismo
Proteína HMGB1/metabolismo
Modelos Animais de Doenças
Inflamação/metabolismo
Rim/patologia
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-777089
Autor: Arslan, Aynur; Kuyrukluyildiz, Ufuk; Binici, Orhan; Cetin, Nihal; Balci, Mecdi Gurhan; Kuzucu, Mehmet; Yilmaz, Adnan; Altuner, Durdu; Coban, Taha Abdulkadir.
Título: Can thiamine pyrophosphate prevent desflurane induced hepatotoxicity in rats?
Fonte: Acta cir. bras;31(3):168-175, Mar. 2016. graf.
Idioma: en.
Projeto: Erzincan University Scientific Research Projects Department.
Resumo: ABSTRACT PURPOSE : To investigate the effects of thiamine pyrophosphate (TPP) against desflurane induced hepatotoxicity. METHODS : Thirty experimental animals were divided into groups as healthy (HG), desflurane control (DCG) , TPP and desflurane group (TDG). 20 mg/kg TPP was injected to intraperitoneally TDG. After one hour of TPP administration, desflurane was applied for two hours. After 24 hours, liver tissues of the animals killed with decapitation were removed. The oxidant/antioxidant levels and ALT, AST and LDH activities were measured. The histopathological examinations were performed in the liver tissues for all rats. RESULTS : Notwithstanding the levels of oxidants and liver enzymes were significantly increased (p<0.0001), antioxidant levels were significantly decreased in DCG (p<0.0001). On contrary to the antioxidant parameters were increased (p<0.05) the oxidant parameters and liver enzymes were decreased in TDG (p<0.0001). Whereas multiple prominent, congestion, hemorrhage and dilatation were observed in sinusoids and lymphocyte-rich inflammation results in the centrilobular and portal areas of liver tissue in DCG, these findings were observed less frequently in TDG. CONCLUSİON : Thiamine pyrophosphate prevented liver oxidative damage induced with desflurane and may be useful in prophylaxis of desflurane induced hepatotoxicity.
Descritores: Tiamina Pirofosfato/uso terapêutico
Anestésicos Inalatórios/efeitos adversos
Substâncias Protetoras/farmacologia
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Isoflurano/análogos & derivados
-Aspartato Aminotransferases/efeitos dos fármacos
Aspartato Aminotransferases/metabolismo
Ratos Wistar
Peroxidase/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Alanina Transaminase/efeitos dos fármacos
Alanina Transaminase/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Glutationa/efeitos dos fármacos
Glutationa/metabolismo
Isoflurano
L-Lactato Desidrogenase/efeitos dos fármacos
L-Lactato Desidrogenase/metabolismo
Fígado/enzimologia
Fígado/patologia
Malondialdeído/metabolismo
Óxido Nítrico/metabolismo
Limites: Animais
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-777088
Autor: Kaya, Kürşat; Ciftci, Osman; Cetin, Aslı; Tecellioğlu, Mehmet; Başak, Neşe.
Título: Beneficial effects of glucan against cisplatin side effects on the nervous system in rats 1
Fonte: Acta cir. bras;31(3):198-205, Mar. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, βg was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and βg were given together at the same doses. RESULTS: CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, βg treatment largely prevented oxidative and histopathological negative effects of CP. CONCLUSIONS: Cisplatin has severe neurotoxic effects in rats and βg supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that βg might be useful against CP toxicity in patients with cancer in terms of nervous system.
Descritores: Encéfalo/efeitos dos fármacos
Encefalopatias/prevenção & controle
Cisplatino/efeitos adversos
beta-Glucanas/farmacologia
Antineoplásicos/efeitos adversos
-Encéfalo/metabolismo
Encéfalo/patologia
Encefalopatias/induzido quimicamente
Encefalopatias/patologia
Distribuição Aleatória
Córtex Cerebral/efeitos dos fármacos
Córtex Cerebral/metabolismo
Córtex Cerebral/patologia
Cisplatino/metabolismo
Ratos Sprague-Dawley
Estresse Oxidativo
Substâncias Protetoras/farmacologia
Modelos Animais
Antineoplásicos/metabolismo
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-837712
Autor: Gao, Wenwei; Zhao, Bo; Liu, Lian; Yuan, Quan; Wu, Xiaojing; Xia, Zhongyuan.
Título: Myocardial ischemic post-conditioning protects the lung against myocardial ischemia/reperfusion-induced damage by activating GSK-3
Fonte: Acta cir. bras;32(5):376-387, May 2017. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Natural Science Foundation of Hubei Province.
Resumo: Abstract Purpose: To investigate whether modulating GSK-3β could attenuate myocardial ischemia reperfusion injury (MIRI) induced acute lung injury (ALI) and analyze the underlying mechanism. Methods: Male SD rats were subjected to MIRI with or without myocardial ischemic post-conditioning in the presence or absence of GSK-3β inhibitor. GSK-3β inhibitor was injected peritoneally 10min before MIRI. Lung W/D weight ratio, MPO, PMNs, histopathological changes, TUNEL, Bax, Bcl-2, IL-6, IL-8, IL-10, GSK-3β, and caspase-3 were evaluated in the lung tissues of all rats. Results: After MIRI, lung injury was significantly increased manifested as significant morphological changes and increased leukocytes in the interstitial capillaries, Lung W/D ratio, MPO, and PMN in BALF, which was associated with enhanced inflammation evidenced by increased expressions of IL-6, IL-8 and reduced expression of IL-10. MIRI significantly increased cell apoptosis in the lung as increased levels of apoptotosis, Bax, cleaved caspase-3, and reduced expression of Bcl-2 was observed, which was concomitant with reduced p-GSK-3β. All these changes were reversed/prevented by ischemic post-conditioning, while these beneficial effects of ischemic post-conditioning were abolished by GSK-3β inhibition. Conclusion: Myocardial ischemia reperfusion injury induces acute lung injury by induction of inflammation and cell apoptosis. Ischemic post-conditioning protects the lung from ALI following MIRI by increasing p-GSK-3β.
Descritores: Traumatismo por Reperfusão Miocárdica/prevenção & controle
Substâncias Protetoras/metabolismo
Lesão Pulmonar Aguda/prevenção & controle
Pós-Condicionamento Isquêmico/métodos
Glicogênio Sintase Quinase 3 beta/metabolismo
-Distribuição Aleatória
Regulação para Baixo
Interleucinas/metabolismo
Ratos Sprague-Dawley
Apoptose/efeitos dos fármacos
Peroxidase/metabolismo
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Substâncias Protetoras/farmacologia
Marcação In Situ das Extremidades Cortadas
Modelos Animais
Ativação Enzimática
Proteína X Associada a bcl-2/metabolismo
Caspase 3/metabolismo
Lesão Pulmonar Aguda/enzimologia
Glicogênio Sintase Quinase 3 beta/antagonistas & inibidores
Glicogênio Sintase Quinase 3 beta/farmacologia
Inflamação/metabolismo
Infarto do Miocárdio/patologia
Neutrófilos/enzimologia
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-837690
Autor: Oliveira, Rita de Cássia Silva de; Brito, Marcus Vinicius Henriques; Ribeiro Júnior, Rubens Fernando Gonçalves; Oliveira, Leonam Oliver Durval; Monteiro, Andrew Moraes; Brandão, Fernando Mateus Viegas; Cavalcante, Lainy Carollyne da Costa; Gouveia, Eduardo Henrique Herbster; Henriques, Higor Yuri Bezerra.
Título: Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats
Fonte: Acta cir. bras;32(3):229-235, Mar. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion. Results: Statistical differences were observed in MDA levels between I/R group with all groups (p<0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p<0.05), both in plasma and renal tissue. Conclusion: Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.
Descritores: Tramadol/farmacologia
Traumatismo por Reperfusão/prevenção & controle
Estresse Oxidativo/efeitos dos fármacos
Precondicionamento Isquêmico/métodos
Substâncias Protetoras/farmacologia
Isquemia/prevenção & controle
Rim/irrigação sanguínea
-Fatores de Tempo
Traumatismo por Reperfusão/metabolismo
Distribuição Aleatória
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Terapia Combinada/métodos
Estresse Oxidativo/fisiologia
Isquemia/metabolismo
Rim/metabolismo
Malondialdeído/análise
Limites: Animais
Masculino
Tipo de Publ: Estudos de Validação
Responsável: BR1.1 - BIREME


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Castiglia, Yara Marcondes Machado
Carvalho, Lidia Raquel de
Módolo, Norma Sueli Pinheiro
Vianna, Pedro Thadeu Galväo
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Id: biblio-837689
Autor: Lemos Neto, Sylvio Valença de; Vianna, Isabela Galvão; Castiglia, Yara Marcondes Machado; Golim, Marjorie de Assis; Souza, Aparecida Vitória Gonçalves de; Carvalho, Lídia Raquel de; Deffune, Elenice; Nascimento Junior, Paulo do; Módolo, Norma Sueli Pinheiro; Vianna, Pedro Thadeu Galvão.
Título: Cyclosporine A attenuates apoptosis and necrosis after ischemia-reperfusion-induced renal injury in transiently hyperglycemic rats
Fonte: Acta cir. bras;32(3):203-210, Mar. 2017. tab.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effects of cyclosporine A on renal ischemia-reperfusion injury during transient hyperglycemia in rats. Methods: In a model of ischemia-reperfusion-induced renal injury and transiently induced hyperglycemia by intraperitoneal injection of glucose, 2.5 g.kg-1, Wistar rats were anesthetized with either isoflurane or propofol and received intravenous cyclosporine A, 5 mg.kg-1, five minutes before reperfusion. Comparison groups were isoflurane and propofol sham groups and isoflurane and propofol ischemia-reperfusion-induced renal injury. Renal tubular cell viability was quantitatively assessed by flow cytometry after cell culture and classified as early apoptosis, necrotic cells, and intact cells. Results: Early apoptosis was significantly higher in isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury when compared to both cyclosporine A treated and sham groups. Necrosis percentage was significantly higher in propofol-anesthetized animals subjected to renal ischemia-reperfusion injury. The percentage of intact cells was lower in both, isoflurane and propofol anesthetized animals subjected to renal ischemia-reperfusion injury. Conclusion: In a model of ischemia-reperfusion-induced renal injury, cyclosporine A, 5 m.kg-1, administered five minutes before renal reperfusion in rats with acute-induced hyperglycemia under either isoflurano or propofol anesthesia, attenuated early apoptosis and preserved viability in renal tubular cells, regardless of the anesthetic used.
Descritores: Traumatismo por Reperfusão/prevenção & controle
Ciclosporina/farmacologia
Apoptose/efeitos dos fármacos
Substâncias Protetoras/farmacologia
Hiperglicemia/fisiopatologia
Rim/efeitos dos fármacos
-Pré-Medicação
Fatores de Tempo
Traumatismo por Reperfusão/complicações
Distribuição Aleatória
Propofol/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Anestésicos Intravenosos/farmacologia
Anestésicos Inalatórios/farmacologia
Citometria de Fluxo
Isquemia/prevenção & controle
Isoflurano/farmacologia
Rim/irrigação sanguínea
Rim/patologia
Necrose/prevenção & controle
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-837686
Autor: Brito, Marcus Vinicius Henriques; Yasojima, Edson Yuzur; Percário, Sandro; Ribeiro Júnior, Rubens Fernando Gonçalves; Cavalcante, Lainy Carollyne da Costa; Monteiro, Andrew Moraes; Couteiro, Rodrigo Paracampo; Rodrigues, Ivone Aline da Silva; Santos, Hellen Aparecida Geyer dos.
Título: Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats
Fonte: Acta cir. bras;32(3):211-218, Mar. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the effects of hypertonic saline solution associated to remote ischemic perconditioning in renal ischemia/reperfusion injury in rats. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Hypertonic saline solution group (HSS) treated with hypertonic saline solution (4ml/kg); remote ischemic perconditioning + Hypertonic saline solution group (Per+HSS) with both treatments. After reperfusion, blood samples were collected for BUN and creatinine serum levels analyzes. TBARS were evaluated in plasma and renal tissue to assess oxidative stress. Kidney histopathological examination were performed. Results: Per+HSS group showed a lower degree of renal dysfunction in relation to I/R group, whereas the technique of remote ischemic perconditioning isolated or associated with saline solution significantly reduced oxidative stress and histological damage. Conclusion: Remote ischemic perconditioning associated or not to saline solution promoted reduction of acute renal injury induced by ischemia/reperfusion.
Descritores: Solução Salina Hipertônica/farmacologia
Traumatismo por Reperfusão/prevenção & controle
Precondicionamento Isquêmico/métodos
Substâncias Protetoras/farmacologia
Isquemia/prevenção & controle
Rim/irrigação sanguínea
-Tiobarbitúricos/análise
Fatores de Tempo
Nitrogênio da Ureia Sanguínea
Distribuição Aleatória
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Estresse Oxidativo
Creatinina/sangue
Rim/fisiopatologia
Rim/patologia
Rim/química
Testes de Função Renal
Necrose
Limites: Animais
Masculino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME



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