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Id: biblio-990051
Autor: ElSawy, Naser A; Alkushi, Abdullah G; Alasmari, Wardah Abdullah Mohammed; Sinna, Mustafa M; Header, Eslam A; Elmadbouly, Mohammad A; Sakran, Ashraf Mohamed Elsayed Ali.
Título: Does oregano protect against testicular toxicity produced by ethylene glycol in adult male albino rat? / ¿El orégano protege contra la toxicidad testicular producida por etilenglicol en ratas macho albinas adultas?
Fonte: Int. j. morphol;37(1):358-362, 2019. tab, graf.
Idioma: en.
Resumo: SUMMARY: Origanum vulgare Linn has traditionally been used as a diuretic and antispasmodic. Therefore, we investigated the active extract of Origanum vulgare for possible andrological effect and preventive effects against testicular damage using ethylene glycol rat model of testicular damage, to rationalize its medicinal use. Male Wistar rats received lithogenic treatment comprising of 0.75 % ethylene glycol injection twice with one day interval, then in drinking water, active extract of Origanum vulgare treatment (20 mg/kg) was given for 3 weeks to prevent toxic damage including loss of body weight gain and appetite, Following oral administration of EGME, a rapid decrease in testis weight associated with testicular cell damage was observed. Origanum vulgare treatment (20 mg/kg) prevented as well as reversed toxic changes including loss of body weight gain.

RESUMEN: Origanum vulgare Linn se ha usado tradicionalmente como diurético y antiespasmódico. Por lo tanto, investigamos el extracto activo de Origanum vulgare por su posible efecto andrológico y efectos preventivos contra el daño testicular utilizando el modelo de rata de etilenglicol de daño testicular. El objetivo del estudio fue racionalizar su uso medicinal. Su utilizaron ratas Wistar macho que recibieron un tratamiento litogénico de una inyección de etilenglicol al 0,75 %, dos veces con un intervalo de un día, y luego se administró en agua potable. Se administró el extracto activo del tratamiento con Origanum vulgare (20 mg / kg) durante 3 semanas con el objetivo de prevenir el daño tóxico, la pérdida de peso corporal y el apetito. Tras la administración oral de EGME, se observó una rápida disminución del peso de los testículos asociada al daño de las células testiculares. El tratamiento con Origanum vulgare (20 mg / kg) logró prevenir y revertir las alteraciones tóxicas, incluyendo la pérdida de peso corporal.
Descritores: Testículo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
Origanum/química
Etilenoglicóis/toxicidade
-Doenças Testiculares/prevenção & controle
Testículo/patologia
Ratos Wistar
Substâncias Protetoras
Limites: Animais
Masculino
Ratos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-954058
Autor: Karagoz, Mehmet Ali; Doluoglu, Omer Gokhan; Ünverdi, Hatice; Resorlu, Berkan; Sunay, Mehmet Melih; Demirbas, Arif; Karakan, Tolga; Aydin, Arif.
Título: The protective effect of Papaverine and Alprostadil in rat testes after ischemia and reperfusion injury
Fonte: Int. braz. j. urol;44(3):617-622, May-June 2018. graf.
Idioma: en.
Resumo: ABSTRACT Objective: To investigate the effect of papaverine and alprostadil on testicular torsion-detorsion injury in rats. Materials and Methods: A total of 40 male Wistar-Albino rats were used in this study. Four hours of right testicular torsion was applied to each group, excluding sham oper- ated group. The torsion-detorsion (T/D), T/D + papaverine and T/D + alprostadil groups received saline, papaverine and alprostadil at the same time as surgical detorsion, respectively. At 14 days after the surgical detorsion, ischaemic changes and the degree of damage were evaluated with Cosentino scoring and the Johnson tubular biopsy score (JTBS). Results: JTBS was determined as 8.8±2.7 in the Sham group, 5.08±1.9 in the T/D+papaverine group, 5.29±2.3 in the T/D +alprostadil group and 2.86±1.9 in the TD group. The JTBS was determined to be statistically significantly high in both the T/D + papaverine group and the T/D + alprostadil group compared to the T/D group (p=0.01, p=0.009). In the T/D + papaverine group, 3 (43%) testes were classified as Cosentino 2, 3 (43%) as Cosentino 3 and 1 (14%) as Cosentino 4. In the T/D +alprostadil group, 5 (50 %) testes were classified as Cosentino 2, 3 (30 %) as Cosentino 3 and 2 (20%) as Cosentino 4. Conclusion: The present study indicated that spermatic cord administration of alprostadil and papaverine showed a protective effect against ischemia/reperfusion injury after right-side testes torsion and histological changes were decreased after testicular ischemia reperfusion injury.
Descritores: Papaverina/uso terapêutico
Torção do Cordão Espermático/prevenção & controle
Testículo/irrigação sanguínea
Vasodilatadores/farmacologia
Alprostadil/farmacologia
Isquemia/prevenção & controle
-Papaverina/farmacologia
Torção do Cordão Espermático/patologia
Testículo/patologia
Vasodilatadores/uso terapêutico
Biópsia
Índice de Gravidade de Doença
Alprostadil/uso terapêutico
Traumatismo por Reperfusão/prevenção & controle
Distribuição Aleatória
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Substâncias Protetoras/uso terapêutico
Substâncias Protetoras/farmacologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-950754
Autor: Ortiz, Gustavo; Salica, Juan P; Chuluyan, Eduardo H; Gallo, Juan E.
Título: Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?
Fonte: Biol. Res;47:1-9, 2014. ilus, tab.
Idioma: en.
Resumo: Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell damage that affects the retinal circulation. In turn, this causes hypoxia leading to release of vascular endothelial growth factor (VEGF) to induce the angiogenesis process. Alpha-1 antitrypsin (AAT) is the most important circulating inhibitor of serine proteases (SERPIN). Its targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, proteinase 3 (PR-3) and plasminogen activator (PAI). AAT modulates the effect of protease-activated receptors (PARs) during inflammatory responses. Plasma levels of AAT can increase 4-fold during acute inflammation then is so-called acute phase protein (APPs). Individuals with low serum levels of AAT could develop disease in lung, liver and pancreas. AAT is involved in extracellular matrix remodeling and inflammation, particularly migration and chemotaxis of neutrophils. It can also suppress nitric oxide (NO) by nitric oxide sintase (NOS) inhibition. AAT binds their targets in an irreversible way resulting in product degradation. The aim of this review is to focus on the points of contact between multiple factors involved in diabetic retinopathy and AAT resembling pleiotropic effects that might be beneficial.
Descritores: Inibidores de Serino Proteinase/uso terapêutico
alfa 1-Antitripsina/uso terapêutico
Retinopatia Diabética/tratamento farmacológico
-Hipóxia Celular
Inibidores de Serino Proteinase/metabolismo
Movimento Celular/fisiologia
Quimiotaxia/fisiologia
alfa 1-Antitripsina/metabolismo
NF-kappa B/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Mediadores da Inflamação/antagonistas & inibidores
Óxido Nítrico Sintase/antagonistas & inibidores
Substâncias Protetoras/metabolismo
Receptores Ativados por Proteinase/metabolismo
Retinopatia Diabética/fisiopatologia
Radicais Livres
Inflamação/metabolismo
Anti-Inflamatórios/metabolismo
Anti-Inflamatórios/uso terapêutico
Neutrófilos/fisiologia
Limites: Humanos
Animais
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-843455
Autor: Koçarslan, Aydemir; Koçarslan, Sezen; Aydin, Mehmet Salih; Gunay, Şamil; Karahan, Mahmut Alp; Taşkın, Abdullah; Üstunel, Murat; Aksoy, Nurten.
Título: Intraperitoneal administration of silymarin protects end organs from multivisceral ischemia/reperfusion injury in a rat model
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);31(6):434-439, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To determine whether intraperitoneal silymarin administration has favorable effects on the heart, lungs, kidney, and liver and on oxidative stress in a rat model of supraceliac aorta ischemia/reperfusion injury. Methods: Thirty male Wistar albino rats were divided equally into three groups: sham, control, and silymarin. The control and silymarin groups underwent supraceliac aortic occlusion for 45 min, followed by a 60 min period of reperfusion under terminal anesthesia. In the silymarin group, silymarin was administered intraperitoneally during ischemia at a dose of 200 mg/kg. Rats were euthanized using terminal anesthesia, and blood was collected from the inferior vena cava for total antioxidant capacity, total oxidative status, and oxidative stress index measurement. Lungs, heart, liver and kidney tissues were histologically examined. Results: Ischemia/reperfusion injury significantly increased histopathological damage as well as the total oxidative status and oxidative stress index levels in the blood samples. The silymarin group incurred significantly lesser damage to the lungs, liver and kidneys than the control group, while no differences were observed in the myocardium. Furthermore, the silymarin group had significantly lower total oxidative status and oxidative stress index levels than the control group. Conclusion: Intraperitoneal administration of silymarin reduces oxidative stress and protects the liver, kidney, and lungs from acute supraceliac abdominal aorta ischemia/reperfusion injury in the rat model.
Descritores: Aorta Abdominal
Silimarina/administração & dosagem
Traumatismo por Reperfusão/tratamento farmacológico
Estresse Oxidativo
Substâncias Protetoras/administração & dosagem
-Traumatismo por Reperfusão/patologia
Ratos Wistar
Modelos Animais de Doenças
Injeções Intraperitoneais
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-897929
Autor: Oliveira, Granville G de; Oliveira, Samer A H de; Botelho, Paulo Henrique H; Oliveira, Marcos Aurelio Barboza de; Bian, Ka; Murad, Ferid.
Título: Tadalafil: protective action against the development of multiple organ failure syndrome
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);32(4):312-317, July-Aug. 2017. tab, graf.
Idioma: en.
Projeto: Brazilian Federal Senate.
Resumo: Abstract Introduction: Multiple organ failure syndrome (MOFS) is a pathology associated to unspecified and severe trauma, characterized by elevated morbidity and mortality. The complex inflammatory MOFS-related reactions generate important ischemia-reperfusion responses in the induction of this syndrome. Nitric oxide elevation, through the activation of cyclic guanosine monophosphate (cGMP), has the potential of counteracting the typical systemic vasoconstriction, and platelet-induced hypercoagulation. Tadalafil would possibly act protectively by reducing cGMP degradation with consequent diffuse vasodilatation, besides reduction of platelet-induced hypercoagulation, thus, preventing multiple organ failure syndrome development. Methods: The experimental protocol was previously approved by an institution animal research committee. Experimental MOFS was induced through the stereotaxic micro-neurosurgical bilateral anterior hypothalamic lesions model. Groups of 10 Wistar rats were divided into: a) Non-operated control; b) Operated control group; c) 2 hours after tadalafil-treated operated group; d) 4 hours after tadalafil-treated operated group; e) 8 hours after post-treated operated group. The animals were sacrificed 24 hours after the neurosurgical procedure and submitted to histopathologic examination of five organs: brain, lungs, stomach, kidneys, and liver. Results: The electrolytic hypothalamic lesions resulted in a full picture of MOFS with disseminated multiple-organs lesions, provoked primarily by diffusely spread micro-thrombi. The treatment with tadalafil 2 hours after the micro-neurosurgical lesions reduced the experimental MOFS lesions development, in a highly significant level (P<0.01) of 58.75%. The treatment with tadalafil, 4 hours after the micro-neurosurgically-induced MOFS lesions, also reduced in 49.71%, in a highly significant level (P<0.01). Finally, the treatment with tadalafil 8 hours after the neurosurgical procedure resulted in a statistically significant reduction of 30.50% (P<0.05) of the experimentally-induced MOFS gravity scores. Conclusion: The phosphodiesterase 5 inhibitor, tadalafil, in the doses and timing utilized, showed to protect against the experimentally-induced MOFS.
Descritores: Substâncias Protetoras/uso terapêutico
Inibidores da Fosfodiesterase 5/uso terapêutico
Tadalafila/uso terapêutico
Insuficiência de Múltiplos Órgãos/prevenção & controle
-Trombose/induzido quimicamente
Trombose/reabilitação
Hipotálamo Anterior/lesões
Técnicas Estereotáxicas
Ratos Wistar
Progressão da Doença
Substâncias Protetoras/administração & dosagem
Modelos Animais de Doenças
Período Pré-Operatório
Inibidores da Fosfodiesterase 5/administração & dosagem
Tadalafila/administração & dosagem
Insuficiência de Múltiplos Órgãos/classificação
Insuficiência de Múltiplos Órgãos/etiologia
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: biblio-958430
Autor: Wang, Longfei; Li, Yong; Lin, Shenglan; Pu, Zhiqiang; Li, Haiping; Tang, Zhili.
Título: Protective effects of baicalin on experimental myocardial infarction in rats
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);33(4):384-390, July-Aug. 2018. tab, graf.
Idioma: en.
Resumo: Abstract Objective: This study aimed to investigate the protective effects of baicalin on myocardial infarction in rats and explore the related mechanisms. Methods: Fifty Sprague Dawley rats were randomly divided into the control, model, and low-, medium- and high-dose baicalin groups. The latter 3 groups were intraperitoneally injected with baicalin, with a dose of 12.5, 25 and 50 mg/kg, respectively. Then, the myocardial infarction model was established. The hemodynamic of rats was tested, the serum lactate dehydrogenase (LDH), creatine kinase-MB (CK-MB), prostacyclin (PGI2) and thromboxane A2 (TXA2) were determined, the myocardial superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected, and the myocardial B-cell lymphoma-2 (Bcl-2) and Bcl-2 associated X (Bax) protein expressions were determined. Results: Compared with the model group, in the high-dose baicalin group the ST segment height and LVEDP were significantly decreased (P<0.05), the LVSP was significantly increased (P<0.05), the serum LDH, CK-MB and TXA2 levels were significantly decreased (P<0.05), the PGI2 level was significantly increased (P<0.05), the myocardial SOD level was significantly increased (P<0.05), and the myocardial MDA level was significantly decreased (P<0.05); the myocardial Bcl-2 protein level was significantly increased, and the Bax protein level was significantly decreased (P<0.05). Conclusion: Baicalin has protective effects on myocardial infarction in rats. The possible mechanisms may be related to its resistance to oxidative stress, and up-regulation of Bcl-2 protein expression and down-regulation of Bax protein expression in myocardial tissue.
Descritores: Flavonoides/farmacologia
Substâncias Protetoras/farmacologia
Infarto do Miocárdio/prevenção & controle
-Valores de Referência
Superóxido Dismutase/análise
Tromboxano A2/sangue
Ensaio de Imunoadsorção Enzimática
Distribuição Aleatória
Reprodutibilidade dos Testes
Cromatografia Líquida de Alta Pressão
Epoprostenol/sangue
Resultado do Tratamento
Ratos Sprague-Dawley
Genes bcl-2
Creatina Quinase Forma MB/sangue
Proteína X Associada a bcl-2/análise
Hemodinâmica/efeitos dos fármacos
L-Lactato Desidrogenase/sangue
Malondialdeído/análise
Limites: Animais
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1013463
Autor: Valente, Acrisio Sales; Lustosa, Gustavo Porto; Mota, Lia Alves Martins; Lima, Adriano; Mesquita, Fernando Antônio de; Gondim, Aloísio; Rodrigues, Fábio Alércio; Pompeu, Ronald Guedes; Branco, Klébia Castelo.
Título: Comparative analysis of myocardial protection with htk solution and hypothermic hyperkalemic blood solution in the correction of acyanogenic congenital cardiopathies - a randomized study
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);34(3):271-278, Jun. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Objective: The goal of the present study was to compare the myocardial protection obtained with histidine-tryptophan-ketoglutarate (HTK) cardioplegic solution (Custodiol®) and with intermittent hypothermic blood solution. Methods: Two homogenous groups of 25 children with acyanotic congenital heart disease who underwent total correction with mean aortic clamping time of 60 minutes were evaluated in this randomized study. Troponin and creatine kinase-MB curves, vasoactive-inotropic score, and left ventricular function were obtained by echocardiogram in each group. The values were correlated and presented through graphs and tables after adequate statistical treatment. Results: It was observed that values of all the studied variables varied over time, but there was no difference between the groups. Conclusion: We conclude that in patients with acyanotic congenital cardiopathies submitted to total surgical correction, mean aortic clamping time around one hour, and cardiopulmonary bypass with moderate hypothermia, the HTK crystalloid cardioplegic solution offers the same myocardial protection as the cold-blood hyperkalemic cardioplegic solution analyzed, according to the variables considered in our study model.
Descritores: Soluções Cardioplégicas/uso terapêutico
Cardiopatias Congênitas/cirurgia
-Cloreto de Potássio/uso terapêutico
Procaína/uso terapêutico
Valores de Referência
Fatores de Tempo
Troponina/análise
Ecocardiografia
Método Duplo-Cego
Estudos Prospectivos
Reprodutibilidade dos Testes
Análise de Variância
Função Ventricular Esquerda
Resultado do Tratamento
Estatísticas não Paramétricas
Substâncias Protetoras/uso terapêutico
Creatina Quinase Forma MB/análise
Duração da Cirurgia
Glucose/uso terapêutico
Cardiopatias Congênitas/fisiopatologia
Manitol/uso terapêutico
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-950794
Autor: Hafez, Mohamed M; Al-Harbi, Naif O; Al-Hoshani, Ali Rashed; Al-hosaini, Khaled A; Al Shrari, Shakir D; Al Rejaie, Salim S; Sayed-Ahmed, Mohamed M; Al-Shabanah, Othman A.
Título: Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats
Fonte: Biol. Res;48:1-10, 2015. graf, tab.
Idioma: en.
Projeto: KSU.
Resumo: BACKGROUND: Carbon tetrachloride (CCl4) induces hepatotoxicity in animal models, including the increased blood flow and cytokine accumulation that are characteristic of tissue inflammation. The present study investigates the hepato-protective effect of rutin on CCl4-induced hepatotoxicity in rats. RESULTS: Forty male Wistar rats were divided into four groups. Group I (control group) received 1 mL/kg of dimethyl sulfoxide intragastrically and 3 mL/kg olive oil intraperitoneally twice a week for 4 weeks. Group II received 70 mg/ kg rutin intragastrically. Groups III and IV received CCl4 (3 mL/kg, 30 % in olive oil) intraperitoneally twice a week for 4 weeks. Group IV received 70 mg/kg rutin intragastrically after 48 h of CCl4 treatment. Liver enzyme levels were determined in all studied groups. Expression of the following genes were monitored with real-time PCR: interleukin-6 (IL-6), dual-specificity protein kinase 5 (MEK5), Fas-associated death domain protein (FADD), epidermal growth factor (EGF), signal transducer and activator of transcription 3 (STAT3), Janus kinase (JAK), B-cell lymphoma 2 (Bcl2) and B-cell lymphoma-extra-large (Bcl-XL). The CCl4 groups showed significant increases in biochemical markers of hepatotoxicity and up-regulation of expression levels of IL-6, Bcl-XL, MEK5, FADD, EGF, STAT3 and JAK compared with the control group. However, CCl4 administration resulted in significant down-regulation of Bcl2 expression compared with the control group. Interestingly, rutin supplementation completely reversed the biochemical markers of hepatotoxicity and the gene expression alterations induced by CCl4. CONCLUSION: CCl4 administration causes alteration in expression of IL-6/STAT3 pathway genes, resulting in hepatotoxicity. Rutin protects against CCl4-induced hepatotoxicity by reversing these expression changes.
Descritores: Rutina/farmacologia
Transdução de Sinais/efeitos dos fármacos
Interleucina-6/metabolismo
Fator de Transcrição STAT3/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
-Aspartato Aminotransferases/sangue
Tetracloreto de Carbono
Biomarcadores
Expressão Gênica/efeitos dos fármacos
Ratos Wistar
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Substâncias Protetoras/farmacologia
MAP Quinase Quinase 5/metabolismo
Alanina Transaminase/sangue
Fator de Crescimento Epidérmico/metabolismo
Proteína bcl-X/metabolismo
Janus Quinases/metabolismo
Proteína de Domínio de Morte Associada a Fas/metabolismo
Reação em Cadeia da Polimerase em Tempo Real
Fígado/efeitos dos fármacos
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1132199
Autor: Afarani, Maral Soltani; Mohammadi, Mohammad; Shokri, Maryam Monsef; Mohammadzadeh, Sara.
Título: Investigation of Protective Effect of Matricaria Chamomilla L. Extract on Methotrexate-Induced Hepatotoxicity in Wistar Rat
Fonte: Braz. arch. biol. technol;63:e20180626, 2020. tab, graf.
Idioma: en.
Resumo: Abstract Methotrexate (MTX) was shown to cause oxidative stress and liver damage. The objective was to investigate the possible protective effects of Matricaria Chamomilla L. (chamomile) extract with anti-oxidant and anti-inflammatory properties on the methotrexate-induced liver toxicity. Twenty four Wistar rats were divided into four groups. MTX group was injected intraperitoneally on days 7 and 14 with 20 mg/kg methotrexate. Groups CE200 (chamomile extract 200 mg/kg/day) and CE300 (chamomile extract 300 mg/kg/day) received the same dose of methotrexate added with chamomile extract orally for 15 days at 200 mg/kg and 300 mg/kg respectively and the last group was healthy control group. Results of biochemical analyses indicated serum liver biomarkers (aminotransferases), alkaline phosphatase (ALP), albumin, and liver content of anti-oxidant enzymes (catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px)), reduced glutathione (GSH) and total anti-oxidant capacity (TAC) significantly increased (P <0.05-0.001) to normal in the CE treated groups compared to those of the MTX group. Serum bilirubin and hepatic malondialdehyde (MDA) levels significantly increased (P ˂0.001) in MTX group compared to those of the control group and decreased in CE200 and CE300 groups compared to those of the MTX group. Histopathological study showed inflammatory damage, necrotic cells and lipid infiltration in MTX group. In the groups treated with the chamomile extract, a significant improvement was observed in liver tissue in response to increased dose of the extract. In conclusion, chamomile extract administration could have a protective role in methotrexate-induced liver toxicity in rats through improving anti-oxidant defense system.
Descritores: Extratos Vegetais/uso terapêutico
Metotrexato/toxicidade
Substâncias Protetoras/uso terapêutico
Matricaria/química
Fígado/efeitos dos fármacos
-Ratos Wistar
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1132265
Autor: Altuner, Durdu; Kaya, Tuğba; Suleyman, Halis.
Título: The Protective Effect of Lercanidipine on Indomethacin-Induced Gastric Ulcers in Rats
Fonte: Braz. arch. biol. technol;63:e20190311, 2020. tab, graf.
Idioma: en.
Projeto: Scientific Research Projects Unit of Erzincan Binali Yıldırım University.
Resumo: Abstract Nonsteroidal anti-inflammatory drugs (NSAID) are among the aggressive factors causing gastric ulcer. They cause oxidative damage in the gastric tissue and lead to intracellular calcium deposition. Lercanidipine is a calcium channel blocker derived from the third generation dihydropyridine. The aim of this study is to analyse the effect of lercanidipine on indomethacin-induced gastric ulcers. A total of 24 albino Wistar male rats were divided into four groups; those who received indomethacin 25 mg/kg (IND), 5 mg mg/kg lercanidipine +25 mg/kg indomethacin (LC-5), 10 mg/kg lercanidipine+25mg/kg indomethacin (LC-10) and healthy rats who received 0.5 mL distilled water. Six hours after the application of indomethacin, the animals were sacrificed by high dose thiopental sodium. The stomachs of the animals were excised to perform a macroscopic analysis and the ulcerous region was measured on millimeter paper. All the stomachs were subjected to a biochemical analysis. Macroscopic analysis revealed hyperaemia on the gastric surface of the indomethacin group. Ulcerous tissues formed by oval, circular or irregular mucosal defects in varying diameters and depths were observed on the whole surface of the stomach. Hyperaemia was lower and ulcerous region was smaller in groups LC-5 and LC-10 compared to IND group. Malondialdehyde and myeloperoxidase levels were significantly lower and total glutathione and cyclooxygenase-1 activity were higher in groups LC-5 and LC-10. Lercanidipine did not change the cyclooxygenase-2 activity. Lercanidipine in doses 10 mg/kg is more effective compared to 5 mg/kg. Lercanidipinine can be useful in the treatment of NSAID-induced gastric damage.
Descritores: Úlcera Gástrica/prevenção & controle
Di-Hidropiridinas/uso terapêutico
Substâncias Protetoras/uso terapêutico
-Úlcera Gástrica/induzido quimicamente
Indometacina
Ratos Wistar
Modelos Animais de Doenças
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME



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