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Id: lil-623939
Autor: Camargo, J. L. V. de.
Título: Medium-term protocols for in vivo evaluation of chemical modifiers of carcinogenesis
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):47-50, 1991. ilus, tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Cancer development is a long-term multistep process which allows interventional measure before the clincial disease emerges. the detection of natural substances which can block the process of carcinogenesis is a important as the identification of anti-tumoral drugs since they might be used in chemoprevention of cancer in high-risk groups. In vivo rodent models of chemical caecinogenesis have been used to study plant-derived inhibitors of carcinofenesis such as indols, coumarins, isothiocyanates, flavones, phenols and allyl-sulfides. Since the standard in vivo rodent bioassay is prolonged and expensive, shorter reliable protocols are needed. Two in vivo medium-term protocols for evaluation of modifiers of carcinogenesis are presented, one related to liver and the other to bladder cancer. Both protocols use rats, last 8 and 36 weeks and are based on the two-step concept of carcinogenesis: initiation and promotion. The protocols use respectively the development of altered foci of hepatocytes expressing immunochistochemically the placental form of gluthation S-transferase and the appearence of pre-neoplastic urothelium and papillomas as the "end-points". the use of these protocols for detection of plantpderived inhibitors of carcinogenesis appear warranted.
Descritores: Anticarcinógenos/isolamento & purificação
Anticarcinógenos/uso terapêutico
Anticorpos Antineoplásicos
-Plantas Medicinais/química
Ensaios de Seleção de Medicamentos Antitumorais
Limites: Animais
Responsável: BR1.1 - BIREME


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Id: biblio-951937
Autor: Gürten, Berna; Yenigül, Elçin; Sezer, Ali Demir; Malta, Seyda.
Título: Complexation and enhancement of temozolomide solubility with cyclodextrins
Fonte: Braz. J. Pharm. Sci. (Online);54(2):e17513, 2018. tab, graf, ilus.
Idioma: en.
Projeto: TUBITAK.
Resumo: ABSTRACT Temozolomide is a poorly soluble anti-cancer drug used in the treatment of some brain cancers. Following literature reports about the enhancement of solubility and stability for these kinds of drugs upon complexation with cyclodextrins, we aimed to form an inclusion complex between temozolomide and the different types of cyclodextrins (CDs) to enhance its solubility. In this study, three different cyclodextrins (ß -CD, hydroxyl-ß-CD and γ-CD) were used, and changes in solubility was measured by UV-Vis Spectroscopy and HPLC. Morphological changes upon complexation were shown by the Scanning Electron Microscope (SEM), and weight loss profiles with respect to temperatures which were unique to the compounds were shown by Thermogravimetric Analysis. Changes in heat release profiles were shown by Differential Scanning Calorimeter (DSC). Drug solubility was measured to be increased to around 25% for 1:1 molar ratio for all used CD complexations. Changes of morphology, heat release and weight loss profiles are consistent with the formation of an inclusion complex between CDs and temozolomide. In this study, success was shown in the enhancement of temozolomide solubility upon complexation with different types of CDs. It has been demonstrated that cyclodextrins can be used as complexing agents for poorly soluble anti-cancer drugs, increasing their solubility and hence drug availability
Descritores: Solubilidade
Anticarcinógenos/análise
Ciclodextrinas/efeitos adversos
-Preparações Farmacêuticas
Microscopia Eletrônica de Varredura/métodos
Responsável: BR1.1 - BIREME


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Id: biblio-894176
Autor: Lazcano-Pérez, Fernando; Zavala-Moreno, Ariana; Rufino-González, Yadira; Ponce-Macotela, Martha; García-Arredondo, Alejandro; Cuevas-Cruz, Miguel; Gómez-Manzo, Saúl; Marcial-Quino, Jaime; Arreguín-Lozano, Barbarín; Arreguín-Espinosa, Roberto.
Título: Hemolytic, anticancer and antigiardial activity of Palythoa caribaeorum venom
Fonte: J. venom. anim. toxins incl. trop. dis;24:12, 2018. graf, ilus.
Idioma: en.
Projeto: PAPIIT; . Consejo Nacional de Ciencia y Tecnología (CONACyT).
Resumo: Cnidarian venoms and extracts have shown a broad variety of biological activities including cytotoxic, antibacterial and antitumoral effects. Most of these studied extracts were obtained from sea anemones or jellyfish. The present study aimed to determine the toxic activity and assess the antitumor and antiparasitic potential of Palythoa caribaeorum venom by evaluating its in vitro toxicity on several models including human tumor cell lines and against the parasite Giardia intestinalis. Methods: The presence of cytolysins and vasoconstrictor activity of P. caribaeorum venom were determined by hemolysis, PLA2 and isolated rat aortic ring assays, respectively. The cytotoxic effect was tested on HCT-15 (human colorectal adenocarcinoma), MCF-7 (human mammary adenocarcinoma), K562 (human chronic myelogenous leukemia), U251 (human glyoblastoma), PC-3 (human prostatic adenocarcinoma) and SKLU-1 (human lung adenocarcinoma). An in vivo toxicity assay was performed with crickets and the antiparasitic assay was performed against G. intestinalis at 24 h of incubation. Results: P. caribaeorum venom produced hemolytic and PLA2 activity and showed specific cytotoxicity against U251 and SKLU-1 cell lines, with approximately 50% growing inhibition. The venom was toxic to insects and showed activity against G. intestinalis in a dose-dependent manner by possibly altering its membrane osmotic equilibrium. Conclusion: These results suggest that P. caribaeorum venom contains compounds with potential therapeutic value against microorganisms and cancer.(AU)
Descritores: Giardíase/terapia
Giardia lamblia/parasitologia
Venenos de Cnidários/antagonistas & inibidores
Venenos de Cnidários/toxicidade
-Anticarcinógenos
Ratos Wistar
Venenos de Cnidários/uso terapêutico
Hemolíticos
Limites: Animais
Masculino
Ratos
Responsável: BR33.1 - Divisão Técnica de Biblioteca e Documentação


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Id: biblio-889436
Autor: Anastácio, Lucas de Barros; Delmaschio, Camila Rocha; Oliveira, Danielle Aparecida; Chequer, Farah Maria Drumond.
Título: Synthetic phosphoethanolamine: the state of the art of scientific production
Fonte: Braz. J. Pharm. Sci. (Online);53(4):e17034, 2017. tab.
Idioma: en.
Resumo: ABSTRACT Cancer is a multifactorial disease and a serious public health problem. Currently, alternative drug treatments for cancer are actively being sought, which is the case of synthetic phosphoethanolamine (PHOS-S), a compound that could possibly have anticarcinogenic effects. To analyze the available scientific evidence to evaluate the anticarcinogenic effects of in vivo and in vitro PHOS-S. A systematic literature review of scientific articles aimed at evaluating the anticarcinogenic potential of PHOS-S, in vivo and in vitro, using the databases PubMed, ScienceDirect, SciElo, CAPES Portal and LILACS. The selected papers suggest a possible anticarcinogenic effect of PHOS-S by inhibiting tumor growth by inducing apoptosis and cell cycle blockade as well as cytotoxic potential against leukemia cells. However, a possible stimulatory effect of tumor growth was also observed. Although some of the evaluated studies indicated a possible anticarcinogenic effect of PHOS-S, the limitations of these studies must be evaluated. Most were performed by the same research group, and in the scientific literature, we identified only preclinical studies (in cells or in animals). No human study has been published. Thus, more studies are needed to confirm the anticarcinogenic capacity of PHOS-S.
Descritores: Anticarcinógenos/análise
Atividades Científicas e Tecnológicas
Neoplasias/tratamento farmacológico
-Bases de Dados Bibliográficas/estatística & dados numéricos
Antineoplásicos/análise
Tipo de Publ: Técnicas In Vitro
Revisão
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1007491
Autor: Mostacero-León, José; De La Cruz-Castillo, Anthony J; Peláez-Peláez, Freddy; Alarcón-Rojas, Narda M; Alva-Calderón, Roger; Charcape-Ravelo, Manuel.
Título: Plantas utilizadas para el tratamiento del cáncer expendidas en los principales mercados de la provincia de Trujillo, Perú, 2016 ­ 2017 / Plants used for the treatment of cancer expanded in the main markets of the province of Trujillo, Peru, 2016 - 2017
Fonte: Bol. latinoam. Caribe plantas med. aromát;18(1):81-94, ene. 2019. tab, ilus, graf, mapas.
Idioma: es.
Resumo: Between 2016 and 2017, we conducted structured interviews with herbalists in market stands in the providence of Trujillo, La Libertad, Peru in order to create a catalog of plants with anticarcinogenic properties. Herbalists shared information about species they use in cancer treatment, including common names, part of the plant used, methods of preparation, plant state, and frequency and method of administration as medicine. We combined this information with the Shannon-Wiener diversity and evenness index to complete a quantitative analysis of the anticarcinogenic species. Our results demonstrate that 46 different species representing 24 genera and 19 families are locally used in cancer treatment, with a Shannon-Wiener index of 3.6 and 0.9 respectively. Our catalog thus represents a great variety of species and source of potentially useful knowledge for fighting cancer.

Con el objetivo de registrar las plantas con propiedades anticancerígenas distribuidas en la provincia de Trujillo, La Libertad, durante el 2016 y 2017, realizamos entrevistas estructuradas a hierbateros con puesto de venta en los mercados de abastos, quienes brindaron información sobre las especies usadas para el tratamiento del cáncer, detallando nombres vulgares, parte del vegetal utilizado, formas de preparación, estado de la plantas, frecuencia y forma de administración; así mismo aplicando los índices de diversidad Shannon- Wiener y Equidad se hizo el análisis cuantitativo de los datos encontrados. Se evidenció que para el tratamiento del cáncer se usan 46 especies, representadas 24 géneros y 19 familias; valor que refleja un Índice de Diversidad y de Equidad de 3.6 y 0.9 respectivamente, indicando que existe una gran variedad de especies y un conocimiento potencialmente valioso para combatir esta enfermedad.
Descritores: Plantas Medicinais
Anticarcinógenos/uso terapêutico
Neoplasias/prevenção & controle
-Peru
Inquéritos e Questionários
Etnobotânica
Medicina Tradicional
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-964309
Autor: Becho, Juliana Raso Marques; Machado, Hussen; Guerra, Martha de Oliveira.
Título: Rutina: estrutura, metabolismo e potencial farmacológico / Rutin: estructure, metabolism and pharmacological potency
Fonte: Rev. interdisciplin. estud. exp. anim. hum. (impr.);1(1):21-25, mar.2009. ilus, tab.
Idioma: en.
Resumo: Os Flavonóides são substâncias naturais amplamente distribuídas no Reino Vegetal. Há um interesse crescente na investigação dessas substâncias, devido ao volume de evidência dos benefícios que eles proporcionam para a saúde. A Rutina é um flavonol glicosídico pertencente a uma importante classe de Flavonóides, sendo extensamente encontrados na natureza, em frutas, vegetais e bebidas como chá e vinho. Pouco se sabe sobre a farmacocinética e biodisponibilidade da rutina, e estes mecanismos tem sido foco de muita controvérsia. Apesar disso, a Rutina apresenta grande importância terapêutica por melhorar a resistência e permeabilidade dos vasos capilares, atividades antioxidante, antiinflamatória, anticarcinogênica dentre outras, razão que levou à realização da presente revisão.

Flavonoids are natural products widely distributed in the vegetable kingdom. There has been increasing interest in research of flavonoids, due to growing evidence of the health benefits of them. Rutin is a glycoside flavonol which belongs to an important class of flavonoids, being extensively found in the nature in fruit, vegetable and beverages, such as tea and wine. About the pharmacokinetics and bioavailability of Rutin, little is stil know, and tis mechanisms have been a matter of much controversy. Dispite it, Rutin presents a therapeutical importance due to improve resistance and permeability of capillaries vessels, antioxidante, antiinflamatory, anticarcinogenic and other important activities. Reason that led to the completion of this review.
Descritores: Rutina/farmacologia
Rutina/farmacocinética
Anticarcinógenos/uso terapêutico
-Disponibilidade Biológica
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: biblio-951869
Autor: Hajmalek, Monireh; Goudarzi, Masoumeh; Ghaffari, Solmaz; Attar, Hossein; Mazlaghan, Mehrnoosh Ghanbari.
Título: Development and validation of a HPTLC method for analysis of Sunitinib malate
Fonte: Braz. j. pharm. sci;52(4):595-601, Oct.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT A simple high performance thin layer chromatography (HPTLC) has been developed and validated for determination of sunitinib malate and possible impurities. The samples were applied in forms of bands on an aluminum TLC plate pre-coated with silica gel and were separated using dichloromethane: methanol: toluene: ammonia solution as the mobile phase. Sunitinib malate was thoroughly separated from impurities including E-isomer, sunitinib N-oxide and impurity B with a retention factor (RF) of 0.35±0.02. Quantitative analysis of sunitinib was carried out using a mobile phase consisting of dichloromethane:methanol:ammonia solution, RF value was 0.53±0.02 for Z isomer. Detection was performed densitometrically in absorbance mode at 430 nm. This method was found to produce sharp, symmetrical, and well resolved peaks. Linear relationship with the coefficients of determination > 0.99 was achieved over the concentration range of 27.34 to 437.5 ng/spot. This method provides robust, replicable and accurate results with acceptable sensitivity.
Descritores: Cromatografia/classificação
Anticarcinógenos/análise
Estudos de Validação
-Cromatografia Líquida de Alta Pressão
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-971955
Autor: Lima, Daisy Jereissati Barbosa.
Título: Estudo da atividade anticâncer da marinobufagenina: um bufadienolídeo extraído de anfíbiosda espécie rhinella marina.
Fonte: Fortaleza; s.n; 2016. 92 p. ilus, tab.
Idioma: pt.
Tese: Apresentada a Universidade Federal do Ceará para obtenção do grau de Mestre.
Resumo: O câncer é uma complexa doença de origem genética, considerada uma das principais causas de morte por doença no mundo. A utilização de substâncias derivadas de produtos naturais tem crescido com o passar dos anos, constituindo uma importante fonte no arsenal terapêutico.Os bufadienolídeos são esteróides cardioativos de24 carbonos, isolados de extratosde glândulasde sapos da família Bufonidae. Essas moléculaspossuem grande variedade de atividades biológicas,incluindo atividadeanticâncer. Os bufadienolídeos tem demonstradocomportamento antiproliferativoemvárias linhagens de células cancerígenas humanas por induzirmortee parada do ciclo celular.A marinobufagenina, umbufadienolídeoextraído do anfíbio Rhinella marina,foi escolhida para determinamos o seu padrão citotóxico e mecanismo de ação. Apesar de demonstrar alta citotoxicidade em células tumorais humanas, a amostranão apresentou citotoxicidade para linhagens murinas. Experimentos in vitro foram realizados utilizando-se a linhagem de adenocarcinoma de próstata PC3. As célulasforam tratadas comdiferentes concentrações da amostramarinobufagenina (0,37, 0,75e 1,5μM)por 24 horas...

Cancer is a complex genetic disease, considered one of the leading causes of death in the world. The use of substances derived from natural products has grown over the years and is an important source forthe therapeutic arsenal. Bufadienolides, a group ofcardioactive steroids with a24 carbonstructures are commonly found inglands of toadsfromBufonidae family.These moleculesahave wide range of biological activities, including anti-cancer effects. Bufadienolides haveshown anti-proliferative effect on various human cancer cell lines by inducing death and cell cycle arrest.Marinobufagenin, abufodienolideextracted fromRhinella marinatoad especies was chosen to determine itsstandard cytotoxic and mechanism of action.Despite showinghigh cytotoxicity in human tumor cells, the sample showed no cytotoxicity to murine strains. In vitro experiments were performed using the PC3 prostateadenocarcinoma lineage. Cells were incubated with different concentrations of marinobufagenin (0.37, 0.75 and 1.5 mM) for 24 hours...
Descritores: Anticarcinógenos
Ciclo Celular
Morte Celular
Adenocarcinoma
Limites: Seres Humanos
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde
BR6.1


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Id: biblio-964190
Autor: Prieto González, Elio A; Spitalnik, Silvina Ruth.
Título: Procarcinógenos y anticarcinógenos en la dieta / Procarcinogens and anticarcinogens in the diet
Fonte: Rev. argent. cancerol;43(3):26-36, 2015.
Idioma: es.
Resumo: La cantidad de información disponible acerca de las relaciones entre nutrición y cáncer es desmesuradamente grande, y también, de difícil interpretación y de aun mucho más compleja implementación práctica
Descritores: Anticarcinógenos
Dieta
Nutrição em Saúde Pública
Neoplasias
Responsável: AR423.1 - Biblioteca


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Id: biblio-912197
Autor: Ysmodes Nastasi, Tíndara Paola.
Título: Efecto de un extracto hidroalcohólico de Uncaria tomentosa (Uña de gato) (Willd. Ex Roem. & Schult) sobre las subpoblaciones de células dendríticas, moléculas accesorias (HLA-DR y CD86) y citoquinas Th1/Th2/Th17 e IL-12 provenientes de células mononucleares de sangre periférica de pacientes con cáncer de mama / Effect of a hydroalcoholic extract of Uncaria tomentosa (Cat's Claw) (Willd. Ex Roem. & Schult) on subpopulations of dendritic cells, accessory molecules (HLA-DR and CD86) and Th1 / Th2 / Th17 and IL-12 cytokines from of peripheral blood mononuclear cells from patients with breast cancer.
Fonte: Lima; s.n; 2013. 61 p.
Idioma: en.
Tese: Apresentada a Universidad Peruana Cayetano Heredia para obtenção do grau de Especialista.
Resumo: Uncaria tomentosa (Una de gato) (Willd. Ex Roem. & Schult) es una liana de la Amazonía peruana y es utilizada por la medicina tradicional por sus propiedades inmunomoduladores y antiinflamatorias. El presente estudio utilizó ensayos in vitro para investigar los efectos inmunomoduladores de un extracto hidroalcohólico de Uncaria tomentosa con 5,03% de alcaloides oxindólicos pentacíclicos (UG-POA) sobre el inmunofenotipo de subpoblaciones de células dendríticas (DC), citoquinas Th1, Th2, Th17 y IL-12 a partir del cultivo de las células mononucleares de sangre periférica (PBMC) de pacientes con cáncer de mama de estadío II y controles sanas. En todos los bioensayos se utilizaron concentraciones de UG-POA entre 50 ­ 1000 µg/mL. Resultados: demostramos que UG-POA no altera las subpoblaciones y sus moléculas accesorias de DC; sin embargo, en los controles sanos se observó una disminución del porcentaje de DCm (mieloides) y un aumento de HLA-DR y CD86 a 1000 µg/mL. La medición de citoquinas demuestra que UG-POA incrementa en ambos grupos las respuestas Th1 (IFN-γ y IL-2), Th2 (IL-4) y Th17 (IL-17). IL-12 solo fue inmunomodulada en el grupo de controles sanos produciéndose un incremento de IL- 12p70 y una disminución de IL-12p40. Conclusiones: A las concentraciones de 500 ­ 1000 µg/mL UG-POA tiene un efecto positivo sobre la respuesta inmune antitumoral y resulta un producto natural promisorio para el uso preventivo y alternativo en terapias anticancerígenas.
Descritores: Citocinas
Anticarcinógenos
Unha-de-Gato
Fatores Imunológicos
-Técnicas In Vitro
Extratos Vegetais
Medicina Tradicional
Limites: Seres Humanos
Responsável: BR1.1 - BIREME



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