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Id: biblio-1293292
Autor: Guzmán, Catherine; Parra, Genoveva; Bozzo, Rodrigo; Pinochet, María José; Moreno, Marcela; Cofré, Fernanda; Valenzuela, José Luis; Jorquera, Rodrigo; Palomino, María Angélica.
Título: Prevalencia de aspergilosis broncopulmonar alérgica en niños con fibrosis quística / Prevalence of bronchopulmonary aspergillosis in children with cystic fibrosis
Fonte: Neumol. pediátr. (En línea);16(2):81-84, 2021. ilus, tab.
Idioma: es.
Resumo: La aspergilosis broncopulmonar alérgica (ABPA) es una reacción de hipersensibilidad secundaria al Aspergillus fumigatus (Af) que complica la evolución en fibrosis quística (FQ). Existen pocos estudios pediátricos de su prevalencia publicados en el mundo y en Chile se desconoce. El objetivo de este trabajo fue estimar la prevalencia de ABPA en niños con FQ en un hospital de referencia, explorar factores de riesgo y describir los criterios diagnósticos, tratamiento y evolución. Se incluyeron retrospectivamente los niños con FQ atendidos en un hospital terciario en Santiago de Chile (Hospital Roberto del Río) entre los años 2011 a 2019, se identificaron aquellos con diagnóstico de ABPA. Se registraron criterios diagnósticos según la Cystic Fibrosis Foundation, presencia de factores de riesgo, tratamientos recibidos y efectos adversos. De 65 pacientes con FQ atendidos en este período, la prevalencia de ABPA fue del 12%. El promedio de edad al diagnóstico fue ± 11 años (5-17 años), predominando la edad adolescente y el género masculino. El 50% cumplieron con los criterios clásicos, el 87,5% usaron antibióticos y el 62,5% corticoides inhalados. La respuesta favorable al tratamiento inicial con corticoides y antifúngico vía oral fue 62,5%, con una exacerbación al momento del estudio. El 25% se comportaron como refractario y el 12,5% respondieron a tratamiento con pulsos de metilprednisolona. El 37,5% presentaron eventos adversos relacionados a corticoides. La prevalencia de ABPA observada es comparable a las series publicadas. Se necesitan trabajos prospectivos para conocer la prevalencia nacional y su tendencia a lo largo de los años, identificando factores de riesgo.

Allergic bronchopulmonary aspergillosis (ABPA) is a hypersensitivity response to Aspergillus fumigatus (Af) and worsens outcome in children with cystic fibrosis (CF). Its prevalence varies in the literature, but we do not know it in Chile. The aim of the study was to know the prevalence of ABPA in children with CF and to describe risk factors, diagnostic criteria, treatment and outcome. We included all patients with CF seen in a tertiary hospital in Santiago, Chile (Hospital Roberto del Río), between 2011 and 2019; ABPA cases (CF Foundation diagnostic criteria) were identified for the estimation of the prevalence. Risk factors, diagnostic criteria and treatment were recorded, as proposed by the Cystic Fibrosis Foundation. A total of 65 patients with CF were identified in the study period, with a prevalence of 12% (8 cases). Mean age at diagnosis ± 11 years (5-17), more frequent in adolescence and male. CF Foundation criteria diagnostic were identified in 50% of cases, with high frequency of antibiotic use (87,5%) and inhaled steroids (62,5%). Positive oral steroids and antifungal treatment response was 62,5%. Refractary response was 25% and 12,5% needed intravenous metilprednisolone pulses. A 37,5% of cases presented adverse effects to steroids. Prevalence of ABPA is comparable to literature. A prospective study is needed to identified national prevalence and trends, identifying risks factors.
Descritores: Aspergilose Broncopulmonar Alérgica/epidemiologia
Fibrose Cística/epidemiologia
-Aspergilose Broncopulmonar Alérgica/diagnóstico
Aspergilose Broncopulmonar Alérgica/tratamento farmacológico
Aspergillus fumigatus
Chile
Prevalência
Fatores de Risco
Fibrose Cística/complicações
Hospitais Pediátricos/estatística & dados numéricos
Antifúngicos/uso terapêutico
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Brasil
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Id: biblio-1278587
Autor: Rodrigues, D K B; Bonfietti, L X; Garcia, R A; Araujo, M R; Rodrigues, J S; Gimenes, V M F; Melhem, M S C.
Título: Antifungal susceptibility profile of Candida clinical isolates from 22 hospitals of São Paulo State, Brazil
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;54(9):e10928, 2021. graf.
Idioma: en.
Projeto: FAPESP.
Resumo: This study aimed to evaluate the frequency of cryptic Candida species from candidemia cases in 22 public hospitals in São Paulo State, Brazil, and their antifungal susceptibility profiles. During 2017 and 2018, 144 isolates were molecularly identified as 14 species; C. parapsilosis (32.6%), C. albicans (27.7%), C. tropicalis (14.6%), C. glabrata (9.7%), C. krusei (2.8%), C. orthopsilosis (2.8%), C. haemulonii var. vulnera (2.1%), C. haemulonii (1.4%), C. metapsilosis (1.4%), C. dubliniensis (1.4%), C. guilliermondii (1.4%), C. duobushaemulonii (0.7%), C. kefyr (0.7%), and C. pelliculosa (0.7%). Poor susceptibility to fluconazole was identified in 6.4% of C. parapsilosis isolates (0.12 to >64 µg/mL), 50% of C. guilliermondii (64 µg/mL), 66.6% of C. haemulonii var. vulnera (16-32 µg/mL), and C. duobushaemulonii strain (MIC 64 µg/mL). Our results corroborated the emergence of C. glabrata in Brazilian cases of candidemia as previously reported. Importantly, we observed a large proportion of non-wild type C. glabrata isolates to voriconazole (28.6%; <0.015 to 4 µg/mL) all of which were also resistant to fluconazole (28.6%). Of note, C. haemulonii, a multidrug resistant species, has emerged in the Southeast region of Brazil. Our findings suggested a possible epidemiologic change in the region with an increase in fluconazole-resistant species causing candidemia. We stress the relevance of routine accurate identification to properly manage therapy and monitor epidemiologic trends.
Descritores: Candida
Antifúngicos/farmacologia
-Brasil
Testes de Sensibilidade Microbiana
Farmacorresistência Fúngica
Hospitais
Responsável: BR1.1 - BIREME


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Id: biblio-1002152
Autor: Alvarez-Moreno, Carlos Arturo.
Título: Antifungal stewardship: consensus on the diagnosis, treatment, and prevention of Candida spp. disease is a fundamental step in the road map to achieve it / Administración de antifungicos: consenso sobre diagnostico, tratamiento y prevención de enfermedad porCandida spp, como paso fundamental en la vía para alcanzar el éxito terapéutico
Fonte: Infectio;23(3):213-214, July-Sept. 2019.
Idioma: en.
Resumo: Antimicrobial resistance is a major public health problem and a principal threat to contemporary medicine. A fundamental principle of controlling antimicrobial resistance are antimicrobial drug stewardship programs, which seeks to preserve the future effectiveness of antimicrobials and improve patient outcome; thus, the selection of the optimal antimicrobial drug regimen, dose, route of administration, and duration of therapy are key to limit inappropriate antimicrobial usage and avoiding unnecessary prescribing, including discontinuing antibiotic therapy if it is not required. However, within the context of stewardship programs, insufficient attention has been given to fungal infections. Furthermore, the importance of the accurate and timely diagnosis of fungal infections in overwhelming antimicrobial resistance has been absent from policy discussions. On the other hand, all serious fungal infections need appropriate antifungal therapy for successful patient outcome. Only a few classes of antifungal drugs are available, so the emergence of resistance to single drug classes and now multidrug resistance threatens the appropriate patient management. Azole resistance among Candida and Aspergillus species is one of the greatest challenges to clinical success, followed by echinocandin and multidrug resistance among some Candida species, especially Candida glabrata. Recently, Candida auris, a cryptic species uncommon in most hospitals around the world, including Colombia, has appeared as an emerging species and a global threat capable of developing resistance to multiple antifungals and with great potential for nosocomial transmission.

La resistencia a los antimicrobianos es un importante problema de salud pública y una de las principales amenazas para la medicina contemporánea. Un principio fundamental del control de la resistencia a los antimicrobianos son los programas de administración de medicamentos antimicrobianos, que buscan preservar la eficacia futura de los antimicrobianos y mejorar el resultado de los pacientes; por lo tanto, la selección del régimen óptimo de medicamentos antimicrobianos, la dosis, la vía de administración y la duración de la terapia son clave para limitar el uso inapropiado de antimicrobianos y evitar la prescripción innecesaria, incluyendo la interrupción de la terapia antibiótica si no es necesaria. Sin embargo, en el contexto de los programas de administración, no se ha prestado suficiente atención a las infecciones fúngicas. Además, la importancia del diagnóstico preciso y oportuno de las infecciones fúngicas en la abrumadora resistencia a los antimicrobianos ha estado ausente de los debates políticos. Por otra parte, todas las infecciones fúngicas graves necesitan un tratamiento antifúngico adecuado para que el paciente tenga éxito. Sólo se dispone de unas pocas clases de fármacos antifúngicos, por lo que la aparición de la resistencia a clases de fármacos individuales y ahora la resistencia a múltiples fármacos amenaza el tratamiento adecuado de los pacientes. La resistencia a los azoles entre las especies de Candida y Aspergillus es uno de los mayores retos para el éxito clínico, seguido de la resistencia a las equinocandinas y a los múltiples fármacos entre algunas especies de Candida, especialmente Candida glabrata. Recientemente, Candida auris, una especie críptica poco común en la mayoría de los hospitales del mundo, incluyendo Colombia, ha aparecido como una especie emergente y una amenaza global capaz de desarrollar resistencia a múltiples antifúngicos y con gran potencial de transmisión nosocomial.
Descritores: Terapêutica
Candida
Antifúngicos
-Aspergillus
Efetividade
Resistência Microbiana a Medicamentos/efeitos dos fármacos
Equinocandinas
Limites: Humanos
Tipo de Publ: Editorial
Responsável: CO359.1 - ACIN - Asociación Colombiana de Infectologia


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Texto completo SciELO Chile
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Id: biblio-902586
Autor: Radich R, Jasna; Álvarez Z, Carlos; Valenzuela R, Ana; Castillo H, Felipe; Moraga V, Francisco; Castillo A, Jorge.
Título: Rol de la cirugía en el manejo de la infección invasora por Saprochaete capitata / Role of surgery in Saprochaete capitata (S. capitata) sepsis in a patient with acute myeloid leukemia
Fonte: Rev. méd. Chile;145(8):1067-1071, ago. 2017. graf.
Idioma: es.
Resumo: Saprochaete capitata (S. capitata) fungal sepsis is a severe condition with a clinical presentation that is similar to other yeast originated fungal sepsis. It is observed in patients with hematological malignancies such as acute myeloid leukemia and neutropenia. We report a 23 year old male presenting with cough, fever and malaise. A bone marrow biopsy led to the diagnosis of acute myeloid leukemia. During the first cycle of chemotherapy the patient presented fever: blood cultures were positive for Klebsiella pneumoniae. Despite antimicrobial treatment, fever persisted; a computed tomography showed a focal splenic lesion; a left exudative pleural effusion appeared. A Matrix Assisted Laser Desorption Ionization-Time of Flight mass spectrometry identified the presence of S. capitata. After multiple antifungal treatments and pleural cavity cleansing by means of videothoracoscopy and laparoscopic splenectomy, the infection resolved and the patient completed his chemotherapy.
Descritores: Leucemia Mieloide Aguda/microbiologia
Fungemia/cirurgia
Dipodascus/isolamento & purificação
-Pleurisia/microbiologia
Pleurisia/patologia
Esplenectomia/métodos
Esplenopatias/cirurgia
Esplenopatias/microbiologia
Esplenopatias/patologia
Drenagem/métodos
Resultado do Tratamento
Fungemia/patologia
Fungemia/tratamento farmacológico
Antifúngicos/uso terapêutico
Limites: Humanos
Masculino
Adulto Jovem
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-952125
Autor: Jana, Abhishek; Thomas, Jimcy; Ghosh, Pratiti.
Título: P-glycoprotein expression in oral lichen planus
Fonte: Braz. oral res. (Online);31:e95, 2017. tab, graf.
Idioma: en.
Resumo: Abstract: Oral lichen planus (OLP) is a stress induced inflammatory condition with malignant potency. The mdr1 (multidrug resistance) is a stress gene overexpressed in cancerous conditions and its translated form, the p-glycoprotein efflux transporter is usually overexpressed with chemotherapy, leading to chemoresistance. OLP, a lesion with carcinogenic potency, is broadly classified into the asymptomatic reticular form and the aggressive erosive form. The objective of the study was to verify the expression level of p-glycoprotein in antifungal-treated and untreated reticular OLP, in untreated erosive OLP and erosive OLP patients treated with corticosteroid. Semi-quantitative reverse transcriptase polymerase chain reaction (SQ-RTPCR) and ELISA were performed on biopsy tissue samples to evaluate the mdr1 mRNA and protein expression of p-glycoprotein, respectively. The present study shows for the first time that mdr1 mRNA as well as its translated form p-glycoprotein are overexpressed in OLP subjects compared to healthy individuals. This overexpression is significantly higher in erosive than in reticular OLP patients, further confirming that the erosive form has higher risk for multidrug resistance. A higher expression is also observed in corticosteroid-treated erosive cases than similar untreated ones. The gradation of expression is in conformity with severity of the disease.
Descritores: Corticosteroides/uso terapêutico
Líquen Plano Bucal/metabolismo
Líquen Plano Bucal/tratamento farmacológico
Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo
Antifúngicos/uso terapêutico
-Pele/patologia
Biópsia
Índice de Gravidade de Doença
Ensaio de Imunoadsorção Enzimática
Análise de Variância
Líquen Plano Bucal/patologia
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Farmacorresistência Fúngica Múltipla
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-1247693
Autor: Dantas, Juliana Borges de Lima; Campos, Elisângela de Jesus; Martins, Gabriela Botelho.
Título: Avaliação in vitro do potencial erosivo e cariogênico de antifúngicos tópicos / In vitro evaluation of erosive and cariogenic potential of topical antifungal agents
Fonte: Rev. Ciênc. Méd. Biol. (Impr.) = J. med. biol. sci;17(3):315-321, nov 19, 2018. tab, ilus.
Idioma: pt.
Resumo: Introdução: a candidíase é uma infecção fúngica oportunista, causada pela proliferação e disseminação de espécies de Candida, que pode acometer a cavidade oral. Dentre os antifúngicos mais utilizados e de uso tópico, a nistatina é considerada o medicamento de primeira escolha. Objetivo: avaliar as propriedades físico-químicas de diferentes marcas de nistatina disponíveis no mercado, incluindo o pH, a acidez total titulável (ATT) e a determinação de sólidos solúveis totais (SST). Metodologia: trata-se de um estudo experimental in vitro, constituído por uma amostra de oito diferentes marcas de nistatina em suspensão oral de uso tópico. Foi analisado o potencial erosivo e cariogênico dessas soluções mediante a determinação de pH, ATT e SST (°Brix). Resultados: no tocante ao pH, verificou-se que a média obtida foi de 6,05 (± 0,66). Dois dos medicamentos analisados (marcas A e H) apresentaram pH abaixo do crítico para a dissolução do esmalte dental. Quanto à ATT das soluções, os valores variaram de 1,9 a 14,53 mL para atingir o pH neutro, indicando que as marcas B, C e E podem levar mais tempo para ser neutralizadas em razão da quantidade de solução necessária. A análise do °Brix revelou que a marca H apresentou o maior teor de açúcares em sua composição (44,9%). Conclusão: a formulação de nistatina da marca H apresentou pH endógeno mais crítico e percentual de sólidos solúveis totais elevado, sendo, portanto, a medicação com maior fator de risco para o desenvolvimento de cárie e erosão dentária, devendo ser consideradas as doses e frequências de uso, bem como os hábitos de higiene oral do paciente

Introduction: candidiasis is an opportunistic fungal infection caused by the proliferation and spread of Candida species that can affect the oral cavity. Among the most commonly used topical antifungal agents, nystatin is considered the first choice drug. Methodology: to evaluate the physical and chemical properties of different brands of nystatin available in the market, including pH, titratable acidity and determination of total soluble solids. Results: Regarding pH, it was verified that the mean obtained was 6.05 (± 0.66). Two of the analyzed drugs (A and H) presented pH below that considered critical for the dissolution of dental enamel. As for the titratable total acidity of the solutions, values ranged from 1.9 to 14.53 mL to reach neutral pH, indicating that the B, C and E marks may take longer to neutralize because of the amount of solution required. The analysis of ° Brix revealed that the H mark had the highest sugar content in its composition (44.9%). Conclusion: Nystatin brand H presented the worst indices in terms of endogenous pH and total sugar percentage, being therefore the medication with the highest risk factor for the development of caries and dental erosion.
Descritores: Erosão Dentária/induzido quimicamente
Candidíase Bucal/tratamento farmacológico
Cariogênicos/análise
Nistatina/efeitos adversos
Antifúngicos/efeitos adversos
Tipo de Publ: Estudo de Avaliação
Responsável: BR342.1 - Biblioteca Universitária de Saúde


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Id: biblio-1292499
Autor: Souza, Ana Clara de; Paula, Claudete Rodrigues; Ruiz, Luciana da Silva; Margarido, Paulo Francisco Ramos; Auler, Marcos Ereno; Lorenzi, Noely Paula Cristina; Moreira, Debora; Santos, Rennan Luiz Oliveira dos; Tacla, Maricy; Crosato, Edgard Michel; Domaneschi, Carina.
Título: Relation between CANDIDA species isolated from vaginal mucosa and lesions caused by high-risk human papillomavirus hpv for cervical cancer
Fonte: Rev. patol. trop;50(3), 2021. ilus.
Idioma: en.
Resumo: This study characterized and related yeasts of the genus Candida isolated from vaginal mucous membranes of women with lesions caused by high-risk HPV for cervical cancer. Forty-two women treated at the Lower Genital Tract Pathology Clinic of the University of São Paulo Medical School Hospital of Clinics were examined, with 30 high-grade (G1) uterine lesions with a mean age of 36.5 years ± 11. 1 and 12 with low grade (G2) uterine lesions with a mean age of 34.7 years ± 15.5. Clinical conditions and laboratory data on HPV were collected from patients' medical records; the socio-demographic data obtained from an appropriate questionnaire. For the study of association between the variables, Odds Ratio analysis was used from the STATA 13.1 program. Patients G1 had a higher prevalence for diabetes and the results indicated 27% prevalence of Candida spp. in vaginal mucosa, in G2 this was 33% in vaginal mucosa. Among the species found in vaginal mucosa of patients, Candida albicans was the most isolated with 88%, followed by C. tropicalis (8%) and C. glabrata (4%). The strains of C. albicans isolated from mucosa presented sensitivity to all antifungal agents tested, unlike the C. tropicalis strain isolated in G2 in vaginal mucosa, which presented a resistance profile to fluconazole. Thus, monitoring and supervision through clinical and laboratory testing of HPV patients is important, reinforcing the need for care, treatment and prevention of HPV-related infections and Candida spp.
Descritores: Papillomaviridae
Candida albicans
Neoplasias do Colo do Útero
Membrana Mucosa
Antifúngicos
Limites: Humanos
Feminino
Tipo de Publ: Relatos de Casos
Responsável: BR15.1 - Biblioteca de Ciências Biomédicas


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Id: biblio-1281778
Autor: Ialea, Darío Emmanuel; Soler, Cecilia Noemí; Faur, María Sol; Viadaña, Julieta; Manzur, Lucía; Palano, María Agustina; Puebla, María Florencia.
Título: Histoplasmosis: informe de un caso / Histoplasmosis: a case report
Fonte: Rev. Asoc. Odontol. Argent;109(1):59-63, ene.-abr. 2021. ilus.
Idioma: es.
Resumo: Objetivo: Describir el diagnóstico y el tratamiento interdisciplinario de un caso clínico de histoplasmosis. Caso clínico: Un paciente masculino de 39 años, con antecedentes de consumo de drogas, alcohol, tabaquismo crónico y VIH+ sin adherencia al tratamiento, acudió al Servicio de Odontología por una interconsulta del Servicio de Clínica Médica para la evaluación de lesiones erosivas en paladar duro y blando, reborde alveolar anterior, dorso lingual y lesión tumoral en encía anterosuperior. El diagnóstico definitivo se obtuvo por medio del análisis de muestras de biopsia transbronquial, lavado broncoalveolar y biopsia de lesión en piel. El paciente recibió tratamiento sistémico con antimicóticos (anfotericina B e itraconazol según esquema) y tratamiento local con colutorio de clorhexidina al 0,12% y 100.000 UI de nistatina en suspensión. Al momento del alta, presentaba una considerable mejoría de su estado general y de las lesiones orales, con disminución de sintomatología dolorosa. Se indicó turno para control a los 7 días de forma ambulatoria, al cual el paciente no asistió. El abordaje interdisciplinario y el análisis de los diferentes aspectos socioeconómicos, culturales, ambientales y sistémicos del paciente facilitaron el diagnóstico temprano de la enfermedad (AU)

Aim: To describe the diagnosis and interdisciplinary treatment of a clinical case of histoplasmosis. Clinical case: 39-year-old male patient with a history of drug abuse, alcohol, and chronic smoking, HIV+ without treatment compliance, attends the dental department referred by the medical department for the diagnosis of erosive lesions in the hard and soft palate, anterior alveolar ridge, lingual dorsum and tumor lesion in the anterosuperior gingiva. The definitive diagnosis was obtained by the analysis of transbronchial biopsy, bronchoalveolar lavage and skin lesion biopsy. The patient received systemic treatment with antifungals (amphotericin b, itraconazole according to protocol), and local treatment with 0.12% chlorhexidine mouthwash and 100,000 IU nystatin suspension. At the time of medical discharge, the patient presented a considerable improvement in his general condition and of the oral lesions with a reduced pain. A 7 days recall was prescribed, however the patient failed to attend. The interdisciplinary approach to the patient and the analysis of the different socio-economic, cultural, environmental and systemic aspects of the patient facilitates the early diagnosis of the disease (AU)
Descritores: Manifestações Bucais
HIV
Assistência Odontológica para Doentes Crônicos
Histoplasmose
-Argentina
Biópsia
Anfotericina B
Nistatina
Imunossupressão/efeitos adversos
Itraconazol
Lavagem Broncoalveolar
Unidade Hospitalar de Odontologia
Diagnóstico Precoce
Mucosa Bucal/lesões
Antifúngicos
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: AR29.1 - Biblioteca


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Texto completo SciELO Chile
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Id: biblio-1058709
Autor: Penna R, Maximiliano; Barahona A, Luis; Ruz M, Paula; Valdés P, Constanza.
Título: Rinosinusitis fúngica invasiva aguda: actualización en pacientes adultos y pediátricos / Acute invasive fungal rhinosinusitis: update in adults and pediatric patients
Fonte: Rev. otorrinolaringol. cir. cabeza cuello;79(3):366-373, set. 2019. graf.
Idioma: es.
Resumo: RESUMEN La rinosinusitis fúngica invasiva aguda (RSFIA) es una enfermedad poco frecuente caracterizada por una infiltración fúngica de la submucosa y vasos sanguíneos de las cavidades nasal y paranasal. Afecta a pacientes con grados variables de inmunosupresión, destacando entre estas patologías subyacentes la diabetes mellitus y las neoplasias malignas hematológicas. Presenta una alta tasa de mortalidad, pudiendo reducirse significativamente si el diagnóstico y el tratamiento se realizan precozmente. Este artículo tiene por objetivo presentar una revisión actualizada de la literatura respecto a la presentación clínica, microbiología, factores de riesgos, métodos diagnósticos, tratamiento y pronóstico de la RSFIA, tanto en adultos como en niños.

ABSTRACT Acute invasive fungal rhinosinusitis (AIFS) is a rare disease characterized by fungal infiltration of the submucosa and blood vessels of the nasal y paranasal cavities. It affects almost exclusively patients with different degrees of immunosuppression, with underlying pathologies such as diabetes mellitus and hematological malignancies. AIFS has a high mortality rate, but it can be significantly reduced if the diagnosis and treatment are carried out early in the course of disease. This article aims to present an updated literature review regarding clinical presentation, microbiology, risk factors, diagnostic methods, treatment and prognosis of AIFS, both in adults and children.
Descritores: Sinusite/microbiologia
Rinite/microbiologia
-Sinusite/diagnóstico
Sinusite/mortalidade
Sinusite/terapia
Rinite/diagnóstico
Rinite/mortalidade
Rinite/terapia
Antifúngicos/uso terapêutico
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CL30.1 - Biblioteca


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Id: biblio-1001611
Autor: Department of Physiological SciencesSilva, Diego Romário; Department of Physiological SciencesRosalen, Pedro Luiz; Freires, Irlan Almeida; Department of Physiological SciencesSardi, Janaína de Cássia Orlandi; Lima, Rennaly Freitas; Department of Physiological SciencesLazarini, Josy Goldoni; Costa, Tereza Karla Vieira Lopes da; Pereira, Jozinete Vieira; Godoy, Gustavo Pina; Costa, Edja Maria Melo de Brito.
Título: Anadenanthera Colubrina vell Brenan: anti-Candida and antibiofilm activities, toxicity and therapeutical action
Fonte: Braz. oral res. (Online);33:e023, 2019. tab, graf.
Idioma: en.
Projeto: National Council for Scientific and Technological Development (CNPq).
Resumo: Abstract: We evaluated the antifungal and antibiofilm potential of the hydroalcoholic extract of bark from Anadenanthera colubrina (vell.) Brenan, known as Angico, against Candida spp. Antifungal activity was evaluated using the microdilution technique through the Minimum Inhibitory and Fungicide Concentrations (MIC and MFC). The antibiofilm potential was tested in mature biofilms formed by Candida species and analyzed through the counting of CFU/mL and scanning electron micrograph (SEM). In vivo toxicity and therapeutic action was evaluated in the Galleria mellonella model. The treatment with the extract, in low doses, was able to reduce the growth of planktonic cells of Candida species. MIC values range between 19.5 and 39 µg/mL and MFC values range between 79 and 625 µg/mL. In addition was able to reduce the number of CFU/mL in biofilms and to cause structural alteration and cellular destruction, observed via SEM. A. colubrina showed low toxicity in the in vivo assay, having not affected the viability of the larvae at doses below 100mg/kg and high potential in the treatment of C. albicans infection. Considering its high antifungal potential, its low toxicity and potential to treatment of infections in in vivo model, A. colubrina extract is a strong candidate for development of a new agent for the treatment of oral candidiasis.
Descritores: Candida/efeitos dos fármacos
Extratos Vegetais/farmacologia
Biofilmes/efeitos dos fármacos
Fabaceae/química
Antifúngicos/farmacologia
-Fatores de Tempo
Microscopia Eletrônica de Varredura
Contagem de Colônia Microbiana
Testes de Sensibilidade Microbiana
Nistatina/farmacologia
Reprodutibilidade dos Testes
Análise de Variância
Responsável: BR1.1 - BIREME



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