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  1 / 96 LILACS  
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Id: biblio-829664
Autor: Hassan, Ehssan Ahmed; Abdel-Rahman, Mohamed Ahmed; Ibrahim, Mohamed Moussa; Soliman, Maha Farid Mohamed.
Título: In vitro antischistosomal activity of venom from the Egyptian snake Cerastes cerastes
Fonte: Rev. Soc. Bras. Med. Trop;49(6):752-757, Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract INTRODUCTION: We studied the potential in vitro antischistosomal activity of Cerastes cerastes venom on adult Schistosoma mansoni worms. METHODS: Live specimens of the horned viper snake, C. cerastes were collected from the Aswan Governorate (Egypt). Venom was collected from snakes by manual milking. Worms of S. mansoni were obtained from infected hamsters by perfusion and isolated from blood using phosphate buffer. Mortality rates of worms were monitored after 3 days of exposure to snake venom at LC50 and various sublethal concentrations (10, 5, 2.5µg/ml). Scanning electron microscopy was used to investigate tegumental changes in treated worms after exposure to LC50 doses of venom. RESULTS: The LC50 of C. cerastes venom was 21.5µg/ml. The effect of C. cerastes venom on Schistosoma worms varied according to their sex. The mortality rate of male and female worms after 48-h exposure was 83.3% and 50%, respectively. LC50 of C. cerastes venom induced mild to severe tegumental damage in Schistosoma worms in the form of destruction of the oral sucker, shrinkage and erosion of the tegument, and loss of some tubercle spines. CONCLUSIONS: The present study demonstrated that C. cerastes venom exerts potential in vitro antischistosomal activity in a time and dose-dependent manner. These results may warrant further investigations to develop novel schistosomicidal agents from C. cerastes snake venom.
Descritores: Schistosoma mansoni/efeitos dos fármacos
Esquistossomicidas/farmacologia
Venenos de Víboras/farmacologia
-Schistosoma mansoni/ultraestrutura
Esquistossomicidas/isolamento & purificação
Fatores de Tempo
Microscopia Eletrônica de Varredura
Cricetinae
Relação Dose-Resposta a Droga
Egito
Dose Letal Mediana
Limites: Animais
Masculino
Feminino
Responsável: BR1.1 - BIREME


  2 / 96 LILACS  
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Teles, Horácio Manuel Santana
Carvalho, Maria Esther de
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Id: lil-325026
Autor: Teles, Horacio Manuel Santana; Carvalho, Maria Esther de; Ferreira, Cláudio Santos; Zacharias, Fabiana; Lima, Valquíria Rosa de; Fadel, Maria Lucia Condino.
Título: Schistosomiasis mansoni in Bananal (State of Säo Paulo, Brazil). I. Efficiency of diagnostic and treatment procedures
Fonte: Mem. Inst. Oswaldo Cruz;97(suppl.1):181-186, Oct. 2002. mapas, tab.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, 8, Recife, Dec. 2-5, 2001.
Resumo: Bananal is an important focus of Schistosoma mansoni in the State of Säo Paulo. Accordingly, programmed active search for human cases, annual coproscopic surveys and treatment of infected cases were started in 1998, aiming at producing a sharp prevalence rate drop by the year 2000. S. mansoni eggs were searched for in two Kato-Katz slides per patient. Cases were followed up according to the routine of the local Family Health Program. In 1998, 130 samples out of 3,860 showed S. mansoni eggs; in 1999, 105 out of 3,550, and in 2000, 64 out of 3,528. Prevalence rates were 3.4 percent, 2.9 percent, and 1.8 percent, and average egg-counts 59, 64, and 79 eggs per gram of feces respectively. Prevalence rates decreased steadily after treatment, but persistently positive cases showed no significant decrease in parasite burdens. Egg count variation depended on sex and age bracket. Persistent residual cases admittedly preclude the eradication of this infection by only searching for and treating carriers. In addition, resistance to therapy and low sensitivity of fecal examinations, can not be ignored. Moderate to heavy worm burdens, frequently associated with hepatomegaly elsewhere, produced no serious cases in Bananal
Descritores: Esquistossomose mansoni
-Oxamniquine
Contagem de Ovos de Parasitas
Schistosoma mansoni
Esquistossomicidas
População Urbana
Esquistossomose mansoni
Brasil
Prevalência
Fezes
Limites: Animais
Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Criança
Adulto
Pessoa de Meia-Idade
Adolescente
Responsável: BR1.1 - BIREME


  3 / 96 LILACS  
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Id: biblio-1089296
Autor: Matos-Rocha, T J; Lima, M C Alves de; Veras, D L; Santos, A F; Silva, A L; Almeida Júnior, A S A; Pitta-Galdino, M R; Pitta, I R; Pitta, M G R; Alves, L C; Brayner, F A.
Título: In Vivo Study of Schistosomicidal Action of (Z) 1 (2 chloro 6 fluoro-benzyl) 5 thioxo 4 (2 4 6 trimethoxy-benzylidene) imidazolidin 2 one
Fonte: Braz. j. biol;80(1):187-189, Feb. 2020. tab.
Idioma: en.
Descritores: Esquistossomicidas
Imidazolidinas
-Schistosoma mansoni
Limites: Animais
Responsável: BR1.1 - BIREME


  4 / 96 LILACS  
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Araújo, Neusa
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Id: lil-623967
Autor: Araújo, Neusa; Kohn, Anna; Katz, Naftale.
Título: Activity of the artemether in experimental schistosomiasis mansoni
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):185-188, 1991. tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: The action of the ether artemisinin (artemether) on Shistosoma mansoni in mice and the hansters experimentally infected with the LE strain was studied. In mice, the drugs showed high schistosomicidal activity using a single intramuscular dose of 100 mg/Kg/day. By the oral route, this dose showed a low activity. Mice treated with a single intramuscular dose of 200 mg/Kg/day, and examined 15 days after treatment, presented 100% alteration of the oogram; when examined 45 days after treatment, the oogram was normal. With doses of 100 mg/Kg/day, i.m., during 3 or 5 consecutive days, the death rate of mice was very high. Morphologic analysis of the worms collected by perfusion of mice treated with a single dose of 100 mg/Kg/day, i.m., detected a marked decrease in the length of male and female forms, degenerative alterations in the parenchyma and in the reproductive system of the females, with reduction of vitellinic material and in ovary volume; the intestinal contents presented a marked despigmentation. In the male worms signifcant alteration was not apparent by optical microscopy.
Descritores: Schistosoma mansoni/efeitos dos fármacos
Esquistossomicidas/uso terapêutico
Sesquiterpenos/uso terapêutico
Esquistossomose mansoni/parasitologia
-FRUCTOKINASESABBREVIATIONS AS TOPIC
Limites: Animais
Cobaias
Responsável: BR1.1 - BIREME


  5 / 96 LILACS  
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Id: lil-623563
Autor: Doenhoff, M. J.
Título: The immune-dependence of chemotherapy in experimental schistosomiasis
Fonte: Mem. Inst. Oswaldo Cruz;84(supl.1):31-37, 1989.
Idioma: en.
Conferência: Apresentado em: Simpósio Internacional de Esquistossomose, 2, Apresentado em: Reunião Nacional de Esquistossomose2, Belo Horizonte, 22-27 out. 1989.
Resumo: Experimental evidence indicates that immune effector mechanisms can enhance the activity of schistosomicidal drugs. Praziquantel, oxamniquine, hycanthone and antimony were less effective against Schistosoma mansoni infections in mice immunosuppressed by T cell-deprivation, than against comparable infection in normal mice. The schistosomicidal activities of praziquantel, oxamniquine and antimony have been experimentally enhanced by the synergistic action of immune sera. In passive serum transfer experiments a s. mansoni antigen of Mr 27 kD with non-specific esterase activity was identified as a potentially sensitive target for the antibodies that interact with praziquantel. Indirect immunofluorescence indicated that this antigen was exposed on the worm surface as a result of praziquantel treatment.
Descritores: Schistosoma mansoni/imunologia
Esquistossomicidas/uso terapêutico
Esquistossomose mansoni/tratamento farmacológico
Anticorpos Anti-Helmínticos/imunologia
Soros Imunes/administração & dosagem
-Praziquantel/uso terapêutico
Tolerância Imunológica
Limites: Animais
Cobaias
Coelhos
Responsável: BR1.1 - BIREME


  6 / 96 LILACS  
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Id: lil-623717
Autor: Bina, José Carlos.
Título: Influência da terapêutica específica na prevenção e reversão das formas graves da esquistossomose / Influence of specific therapy on prevention and reversal of severe forms of schistosomiasis
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):331-332, 1987. tab.
Idioma: pt.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Baço/patologia
Esquistossomose mansoni/prevenção & controle
Esquistossomose mansoni/tratamento farmacológico
-Esquistossomicidas/uso terapêutico
Avaliação de Medicamentos
Limites: Humanos
Responsável: BR1.1 - BIREME


  7 / 96 LILACS  
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Beçak, Willy
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Id: lil-623701
Autor: Almeida, Terezinha M. B; Silva, Luiz C. da; Almeida, Vagner F; Beçak, Willy.
Título: Study of the in vitro cell proliferation of lymphocytes from Manson's Schistosomiasis patients treated with praziquantel
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):243-243, 1987.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Esquistossomicidas/uso terapêutico
Esquistossomicidas/farmacologia
Esquistossomose mansoni/patologia
-Esquistossomose mansoni/tratamento farmacológico
Linfócitos/patologia
Limites: Humanos
Responsável: BR1.1 - BIREME


  8 / 96 LILACS  
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Id: lil-623682
Autor: Brindley, Paul J; Sher, Alan.
Título: Anti-schistosomal drugs: observations on the mechanism of drug resistance to hycanthone, and on the involvement of host antibodies in the mode of action of praziquantel
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):157-161, 1987. graf.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Resumo: This paper reports recent observations from our laboratory dealing with the anti-schistosome drugs hycanthone (HC) and praziquantel (PZQ). In particular, we discuss a laboratory model of drug resistance to HC in Schistosoma mansoni and show that drug sensitive and resistant lines of the parasite can be differentiated on the basis of restriction fragment length polymorphisms using homologous ribosomal gene probes. In addition, we summarize data demonstrating that effective chemotherapy of S. mansoni infection with PZQ in mice requires the presence of host anti-parasite antibodies. These antibodies bind to PZQ treated worms and may be involved in an antibody-dependent cellular cytotoxicity reactions which result in the clearance of worms from the vasculature.
Descritores: Esquistossomicidas/provisão & distribuição
Esquistossomicidas/uso terapêutico
Esquistossomicidas/farmacologia
Responsável: BR1.1 - BIREME


  9 / 96 LILACS  
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Id: lil-623680
Autor: Bruce, John I; Dias, Luiz Candido de Souza; Yung-San, Liang; Coles, Gerald C.
Título: Drug resistance in Schistosomiasis: a review
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):143-150, 1987. tab.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Projeto: FAPESP; . United States of America. National Institutes of Health. National Institute of Allergy and Infectious Diseases.
Resumo: Drug resistance associated with the treatment of human schistosomiasis appears to be an emerging problem requiring more attention from the scientific community than the subject currently receives. Drug-resistant strains of Schistosoma mansoni have been isolated by various investigators as a result of laboratory experimentation or from a combination of field and laboratory studies. Review of this data appears to indicate that the lack of susceptibility observed for some of the isolated strains cannot be ascribed solely to previous administration of antischistosome drugs and thus further studies are required to elucidate this phenomena. Strains of S. mansoni have now been identified from Brazil which are resistant to oxamniquine, hycanthone and niridazole; from Puerto Rico which are resistant to hycanthone and oxamniquine; and from Kenya which are resistant to niridazole and probably oxamniquine. Strains derived by in vitro selection and resistant to oxamniquine and possibly to oltipraz are also available. All of these strains are currently maintained in the laboratory in snails and mice, thus providing for the first time an opportunity for indepth comparative studies. Preliminary data indicates that S. haematobium strains resistant to metrifonate may be occurring in Kenya. This problem could poise great difficulty in the eventual development of antischistosomal agents. Biomphalaria glabrata from Puerto Rico and Brazil were found to be susceptible to drug-resistant S. mansoni from each country.
Descritores: Esquistossomicidas/uso terapêutico
Resistência a Medicamentos/efeitos dos fármacos
Anti-Helmínticos/farmacologia
-Schistosoma mansoni
Esquistossomose mansoni/transmissão
Responsável: BR1.1 - BIREME


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Id: lil-623658
Autor: Paraense, W. Lobato.
Título: Control of Schistosomiasis mansoni: an outlook from current expectation
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):1-12, 1987.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Esquistossomicidas/uso terapêutico
Caramujos/parasitologia
Esquistossomose mansoni/prevenção & controle
Esquistossomose Japônica/prevenção & controle
-Trematódeos
Brasil
Educação em Saúde
Japão
Responsável: BR1.1 - BIREME



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