Base de dados : LILACS
Pesquisa : D27.505.954.248.179 [Categoria DeCS]
Referências encontradas : 97 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 10 ir para página                        

  1 / 97 LILACS  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-1011405
Autor: Farooq, Umar; Naz, Sadia; Shams, Afshan; Raza, Yasir; Ahmed, Ayaz; Rashid, Umer; Sadiq, Abdul.
Título: Isolation of dihydrobenzofuran derivatives from ethnomedicinal species Polygonum barbatum as anticancer compounds
Fonte: Biol. Res;52:1, 2019. tab, graf.
Idioma: en.
Projeto: Higher Education Commission (HEC); . Higher Education Commission; . Higher Education Commission.
Resumo: BACKGROUND: Ethnomedicinally, the family Polygonaceae is famous for the management of cancer. Various species of this family have been reported with anticancer potentials. This study was designed to isolate anticancer compounds from ethnomedicinally important species Polygonum barbatum. METHODS: The column chromatography was used for the isolation of compounds from the solvent fraction of P. barbatum. The characterization of isolated compounds was performed by various spectroscopic techniques like UV, IR, mass spectrometry and 1D-2D NMR spectroscopy. Keeping in view the ethnomedicinal importance of the family, genus and species of P barbatum, the isolated compounds (1-3) were screened for anticancer potentials against oral cancer (CAL-27) and lungs cancer (NCI H460) cell lines using MTT assay. Active compound was further investigated for apoptosis by using morphological changes and flow cytometry analysis. In vivo anti-angiogenic study of the isolated compounds was also carried using chorioallantoic membrane assay. Docking studies were carried out to explore the mechanism of anticancer activity. RESULTS: Three dihydrobenzofuran derivatives (1-3) have been isolated from the ethyl acetate fraction of P. barbatum. The structures of isolated compounds were elucidated as methyl (2S,3S)-2-(3,4-dimethoxyphenyl)-4-((E)-3-ethoxy-3-oxoprop-1-en-1-yl)-7-methoxy-2,3-dihydrobenzo-furan-3-carboxylate (1), (E)-3-((2S,3S)-2-(3,4-dimethoxyphenyl)-7-methoxy-3-(methoxy carbonyl)-2,3-dihydrobenzofuran-4-yl)acrylic acid (2) and (2S,3 S)-4-((E)-2-carboxyvinyl)-2-(3,4-dimethoxyphenyl)-7-hydroxy-2,3-dihydrobenzofuran-3-carboxylic acid (3). The compound 1 was found to be more potent with IC50 of 48.52 ± 0.95 and 53.24 ± 1.49 against oral cancer cells as compared to standard drug (IC50 = 97.76 ± 3.44 µM). Both compound also inhibited lung cancer cells but at higher concentrations. Morphological and flow cytometry analysis further confirms that compound 1 induces apoptosis after 24 to 48 h treatment. In antiangiogenesis assay, compounds 1, 2 and 3 exhibited IC50 values of 8.2 ± 1.1,13.4 ± 1.1 and 57.7 ± 0.3 µM respectively. The docking studies revealed that the compounds under study have the potential to target the DNA and thymidylate synthase (TS). CONCLUSION: Based on its overwhelming potency against the tested cell lines and in angiogenesis assay, compound 1 can be further evaluated mechanistically and can be developed as anticancer drug candidate.
Descritores: Benzofuranos/farmacologia
Carcinoma de Células Escamosas/tratamento farmacológico
Apoptose/efeitos dos fármacos
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Polygonum/química
Proliferação de Células/efeitos dos fármacos
Antineoplásicos Fitogênicos/farmacologia
-Benzofuranos/isolamento & purificação
Benzofuranos/química
Carcinoma de Células Escamosas/patologia
Carcinoma Pulmonar de Células não Pequenas/patologia
Polygonum/classificação
Linhagem Celular Tumoral
Antineoplásicos Fitogênicos/isolamento & purificação
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


  2 / 97 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Chile
Texto completo
Id: biblio-1019499
Autor: Wang, Xiaomin; Peng, Peike; Pan, Zhiqiang; Fang, Zhaoqin; Lu, Wenli; Liu, Xiaomei.
Título: Psoralen inhibits malignant proliferation and induces apoptosis through triggering endoplasmic reticulum stress in human SMMC7721 hepatoma cells
Fonte: Biol. Res;52:34, 2019. tab, graf.
Idioma: en.
Projeto: National Natural Science Foundation of China.
Resumo: BACKGROUND: Psoralen is a coumarin-like and coumarin-related benzofuran glycoside, which is a commonly used traditional Chinese medicine to treat patients with kidney and spleen-yang deficiency symptom. Psoralen has been reported to show estrogen-like activity, antioxidant activity, osteoblastic proliferation accelerating activity, antitumor effects and antibacterial activity. However, the antitumor mechanism of psoralen is not fully understood. This study aimed to investigate the therapeutic efficacy of psoralen in human hepatoma cell line SMMC7721 and the mechanism of antitumor effects. RESULTS: Psoralen inhibited proliferation of SMMC7721 in a dose- and time-dependent manner, and promoted apoptosis. Further, psoralen activated the ER stress signal pathway, including the expansion of endoplasmic reticulum, increasing the mRNA levels of GRP78, DDIT3, ATF4, XBP1, GADD34 and the protein levels of GDF15, GRP78, IRE1α, XBP-1s in a time-dependent manner. Psoralen induces cell cycle arrest at G1 phase by enhancing CyclinD1 and reducing CyclinE1 expression. Moreover, TUDC couldn't inhibit the psoralen-induced ER stress in SMMC7721 cells. CONCLUSIONS: Psoralen can inhibit the proliferation of SMMC7721 cells and induce ER stress response to induce cell apoptosis, suggesting that psoralen may represent a novel therapeutic option for the prevention and treatment hepatocellular carcinoma.
Descritores: Carcinoma Hepatocelular/tratamento farmacológico
Proliferação de Células/efeitos dos fármacos
Estresse do Retículo Endoplasmático/efeitos dos fármacos
Ficusina/farmacologia
Neoplasias Hepáticas/tratamento farmacológico
Antineoplásicos Fitogênicos/farmacologia
-Transdução de Sinais/efeitos dos fármacos
Proteínas Serina-Treonina Quinases/farmacologia
Apoptose/efeitos dos fármacos
Carcinoma Hepatocelular/patologia
Linhagem Celular Tumoral
Ficusina/uso terapêutico
Ficusina/química
Neoplasias Hepáticas/patologia
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


  3 / 97 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-731298
Autor: Francisco, Adriana Amorim; Kinjo, Mirian Hiromi; Bosco, Caroline de Souza; Silva, Renata Luana 
da; Mendes, Edilaine de Paula Batista; Oliveira, Sonia Maria Junqueira Vasconcellos.
Título: Association between perineal trauma and pain in primiparous women / Associación entre el trauma perineal y dolór em primíparas / Associação entre trauma perineal 
e dor em primíparas
Fonte: Rev. Esc. Enferm. USP;48(spe):39-44, 08/2014. tab.
Idioma: en.
Resumo: Objective To identify the association between perineal trauma and pain in 473 primiparous women. Method Cross-sectional study in which pain was measured by the numerical pain scale (0 to 10 - 0 being no pain and 10 maximal pain). Results The prevalence and mean intensity of pain were 33.0% and 4.7 points (standard deviation = 2.0) in the numeric scale, respectively. Episiotomy represented the most frequent trauma (46.7%). The occurrence and intensity of the pain were associated with perineal trauma and postpartum time. Having perineal trauma tripled the chance of pain. Each hour elapsed following the birth reduced the chance of pain by 4.8%. Conclusion Primiparous women are subject to a high frequency of perineal trauma, with episiotomy being the most prominent. Perineal pain affects approximately one-third of primiparous women and is associated with the postpartum time and perineal traumas. .

Objetivo Identificar la asociación entre el trauma y el dolor perineal en 473 primíparas. Método Estudio transversal, en el que el dolor se midió por medio de la escala numérica del dolor (0 a 10; 0 = ningún dolor y 10 = dolor máximo). Resultados La prevalencia y el promedio de intensidad del dolor fueron 33,0% y 4,7 (Desviación Estándar = 2,0) puntos en la escala, respectivamente. La episiotomía fue el trauma más frecuente (46,7%). La ocurrencia y la intensidad del dolor se asociaron con el trauma y el tiempo del postparto. Tener trauma perineal triplica la probabilidad de tener dolor. Cada hora transcurrida después del nacimiento reduce la posibilidad de dolor en 4,8%. Conclusión Las primíparas están sujetas a altas tasas de trauma perineal, especialmente episiotomía. El dolor perineal afecta aproximadamente a un tercio de las primíparas y se asocia con el tiempo de postparto y el traumatismo perineal.

 .

Objetivo Identificar a associação entre trauma perineal e dor em 473 primíparas. Método Estudo transversal, no qual dor foi mensurada por meio da escala numérica de dor (0 a 10 – sendo 0 ausência de dor e 10 dor máxima). A prevalência e a média de intensidade de dor foram 33,0% e 4,7 (Desvio Padrão = 2,0) pontos na escala numérica, respectivamente. Resultados A episiotomia foi o trauma mais frequente (46,7%). A ocorrência e a intensidade da dor foram associadas ao trauma perineal e ao tempo de pós-parto. Ter trauma perineal triplicou a chance de dor. Cada hora decorrida depois do parto reduziu a chance de dor em 4,8%. Conclusão As primíparas estão sujeitas a elevada frequência de trauma perineal, sobretudo episiotomia. A dor perineal afeta, aproximadamente, um terço das primíparas e está associada ao tempo de pós-parto e aos traumas locais. .
Descritores: Antineoplásicos Fitogênicos/administração & dosagem
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Neoplasias da Mama/tratamento farmacológico
Carcinoma Intraductal não Infiltrante/tratamento farmacológico
Paclitaxel/administração & dosagem
Paclitaxel/análogos & derivados
Taxoides
-Neoplasias da Mama/cirurgia
Carcinoma Intraductal não Infiltrante/cirurgia
Floxuridina/administração & dosagem
Infusões Intra-Arteriais
Acetato de Medroxiprogesterona/administração & dosagem
Terapia Neoadjuvante
Limites: Feminino
Humanos
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


  4 / 97 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Cuba
Texto completo
Id: biblio-960662
Autor: Cardona Echeverry, Andrés Hernán; Uribe Yunda, Diego Fernando; Cortés-Mancera, Fabian Mauricio.
Título: Actividad antitumoral de la curcumina asociada a la regulación de mecanismos epigenéticos: implicaciones en la vía Wnt/-catenina / Antitumor activity of curcumin associated with regulation of epigenetic mechanisms: implications for the Wnt/-catenin pathway
Fonte: Rev. cuba. plantas med;21(4), oct.-dic. 2016. ilus, tab.
Idioma: es.
Resumo: Introducción: la curcumina es el principal compuesto polifenólico bioactivo de la planta Curcuma longa. Esta molécula ha mostrado efectos antioxidantes, anti-inflamatorios y anticancerígenos en diferentes modelos experimentales. Como parte de su actividad benéfica en células tumorales, se le ha asociado con la regulación de mecanismos epigenéticos, modulando así diferentes vías de señalización, entre ellas la vía Wnt/ß-catenina, la cual juega un papel fundamental en el desarrollo de cáncer. Objetivos: describir los avances científicos en el estudio de la actividad anti-cancerígena de la curcumina en relación a la modulación de mecanismos epigenéticos y su implicación en la vía Wnt/ß-catenina. Métodos: se realizó una búsqueda sistemática en las bases de datos PubMed, Google Scholar, Scopus y ScienceDirect, utilizando los siguientes criterios de búsqueda: curcumina, epigenética, Wnt/ß-catenina y cáncer. Se incluyeron artículos con importancia científica entre los años 2001-2016, que exploraran la actividad inhibitoria de la curcumina sobre la maquinaria epigenética y/o que evidenciaran un efecto regulador sobre alteraciones en la vía Wnt/ß-catenina. Resultados: se encontró en la literatura una creciente evidencia que involucra a la curcumina con la inhibición de la actividad de enzimas ADN metiltransferasas, acetiltransferasas y desacetilasas de histonas, y por ende en la regulación de alteraciones epigenéticas. Esto lleva a la re-expresión de genes silenciados en diversos tipos de cáncer, lo cual le confiere una actividad antitumoral asociada a la regulación de vías de señalización. En este contexto, se ha demostrado que la curcumina actúa sobre componentes de la vía Wnt/ß-catenina e incluso regula su actividad mediante la desmetilación de antagonistas de Wnt. Conclusiones: este manuscrito discute los potenciales efectos quimiopreventivos de la curcumina asociados con restauración de los mecanismos epigenéticos y la vía de señalización Wnt/ß-catenina(AU)

Introduction: Curcumin is the main bioactive polyphenolic compound in the plant Curcuma longa. This molecule has displayed antioxidant, anti-inflammatory and anti-cancer activity in various experimental models. Its beneficial effect on tumor cells has been associated with the regulation of epigenetic mechanisms, modulating various signaling pathways, among them the Wnt/-catenin pathway, which plays a fundamental role in cancer development. Objectives: Describe the scientific progress achieved in the study of the anti-cancer activity of curcumin in relation to the modulation of epigenetic mechanisms and its implication for the Wnt/?-catenin pathway. Methods: A systematic search was conducted in the databases PubMed, Google Scholar, Scopus and ScienceDirect, using the search terms curcumin, epigenetics, Wnt/?-catenin and cancer. Papers were included which had scientific relevance, had been published between 2001 and 2016, explored the inhibitory activity of curcumin on the epigenetic machinery and/or presented evidence of a regulatory effect on alterations in the Wnt/?-catenin pathway. Results: Growing evidence was found in the literature associating curcumin with inhibition of the activity of the enzymes histone deacetylases, acetyltransferases and DNA methyltransferases, and therefore regulation of epigenetic alterations. This leads to re-expression of silenced genes in various cancer types, granting it antitumor activity associated with the regulation of signaling pathways. In this context, it has been proved that curcumin acts upon components of the Wnt/?-catenin pathway and even regulates their activity through demethylation of Wnt antagonists. Conclusions: The paper discusses the potential chemopreventive effects of curcumin associated with restoration of epigenetic mechanisms and the Wnt/-catenin signaling pathway(AU)
Descritores: Curcumina/uso terapêutico
Epigenômica
Antineoplásicos Fitogênicos/uso terapêutico
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


  5 / 97 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-949359
Autor: Shi, Qingbin; Cai, Xiuying; Shi, Guixiang; Lv, Xingle; Yu, Jinping; Wang, Feng.
Título: Interleukin-4 protects from chemotherapy-induced peripheral neuropathy in mice modal via the stimulation of IL-4/STAT6 signaling
Fonte: Acta cir. bras;33(6):491-498, June 2018. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Methods: The mouse model of vincristine-induced peripheral neuropathy and interleukin (IL)-4 knockout mice were utilized to investigate the possible role of IL-4 signaling pathway in vincristine-induced peripheral neuropathy. Vincristine induced increased sensitivity to mechanical stimulation was measured by von Frey hair test 7 and 14 days after intraperitoneal administration of 0.1 mg/kg vincristine in mice. Relative expression levels of cytokines were detected by quantitative real-time PCR. STAT6 expression following vincristine treatment was assessed with western blotting. Results: We discovered that IL-4/STAT6 signaling was down-regulated in vincristine-treated mice. Deletion of IL-4 in mice increased the sensitivity to mechanical allodynia. IL-4 knockout mice also produced more pro-inflammatory cytokines, including IL-1β and TNF-α. Notably, co-administration of exogenous recombination IL-4 significantly prevented vincristine-induced mechanical allodynia. Conclusion: Anti-inflammatory cytokine IL-4 protects rodent model from vincristine-induced peripheral neuropathy via the stimulation of IL-4/STAT6 signaling and inhibition of the pro-inflammatory cytokines.
Descritores: Vincristina/efeitos adversos
Interleucina-4/farmacologia
Doenças do Sistema Nervoso Periférico/prevenção & controle
Fator de Transcrição STAT6/efeitos dos fármacos
Anti-Inflamatórios/farmacologia
Antineoplásicos Fitogênicos/efeitos adversos
-Fatores de Tempo
Regulação para Baixo/efeitos dos fármacos
Western Blotting
Reprodutibilidade dos Testes
Citocinas/análise
Citocinas/efeitos dos fármacos
Resultado do Tratamento
Camundongos Knockout
Doenças do Sistema Nervoso Periférico/induzido quimicamente
Doenças do Sistema Nervoso Periférico/metabolismo
Fármacos Neuroprotetores
Modelos Animais de Doenças
Fator de Transcrição STAT6/análise
Reação em Cadeia da Polimerase em Tempo Real
Hiperalgesia/induzido quimicamente
Hiperalgesia/tratamento farmacológico
Camundongos Endogâmicos C57BL
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  6 / 97 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: biblio-989062
Autor: Mammadov, Renad; Suleyman, Bahadir; Altuner, Durdu; Demirci, Elif; Cetin, Nihal; Yilmaz, Adnan; Baykal, Huseyin; Alpcan, Hilal; Turumtay, Emine Akyuz; Suleyman, Halis.
Título: Effect of ethyl acetate extract of usnea longissima on esophagogastric adenocarcinoma in rats
Fonte: Acta cir. bras;34(3):e201900305, 2019. graf.
Idioma: en.
Resumo: Abstract Purpose: To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG). Methods: The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats. Results: EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue. Conclusion: This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.
Descritores: Neoplasias Gástricas/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Adenocarcinoma/tratamento farmacológico
Usnea/química
Acetatos/uso terapêutico
Antineoplásicos Fitogênicos/uso terapêutico
-Ratos Wistar
Neoplasias Experimentais/tratamento farmacológico
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


  7 / 97 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-796978
Autor: Faria, Luiza Dib Batista Bugiato; Anjos, Carlos Henrique dos; Fernandes, Gustavo dos Santos; Carvalho, Igor Fernando da Silva.
Título: Pneumatosis intestinalis after etoposide-based chemotherapy in a patient with metastatic small cell lung cancer: successful conservative management of a rare condition / Pneumatose intestinal após quimioterapia com etoposídeo em paciente com câncer de pulmão de pequenas células: sucesso com conduta conservadora em uma condição rara
Fonte: Einstein (Säo Paulo);14(3):420-422, July-Sept. 2016. graf.
Idioma: en.
Resumo: ABSTRACT A 69-year-old male patient, smoker, was diagnosed with small cell lung cancer metastatic to lung, liver and central nervous system. He received chemotherapy with carboplatin AUC 5 on day 1 and etoposide 100mg/m2 on days 1, 2 and 3. During the first cycle, the patient presented with febrile neutropenia and abdominal distension. Chest, abdomen and pelvis computed tomography scan was performed and detected gas dissecting the wall of sigmoid colon extending to the mesosigmoid. Patient had no abdominal pain, nausea, vomiting, and on physical examination he had no peritoneal irritation, tachycardia or hemodynamic instability compatible with perforation or acute abdomen. Therefore, the radiological finding was interpreted as pneumatosis intestinalis caused by chemotherapy with etoposide. Pneumatosis resolved after continuous oxygen therapy. The second cycle was administered after a complete resolution of the clinical condition and etoposide dose was reduced by 30%. The patient experienced a remarkable evolution.

RESUMO Paciente do gênero masculino, 69 anos, fumante, diagnosticado com câncer de pulmão de pequenas células, metastático para pulmão, fígado e sistema nervoso central. Foi administrada quimioterapia com carboplatina AUC 5 no dia 1 e etoposídeo 100mg/m2 nos dias 1, 2 e 3. Durante o primeiro ciclo, o paciente apresentou neutropenia febril e distensão abdominal. Tomografias de tórax, abdome e pelve detectaram gás dissecando a parede do cólon sigmoide, com extensão para o mesossigmoide. O paciente não apresentava dor abdominal, náusea, vômito e não tinha sinais de irritação peritoneal, taquicardia ou instabilidade hemodinâmica compatíveis com perfuração ou abdome agudo. O achado radiológico foi interpretado como pneumatose intestinal causada por etoposídeo. A resolução do quadro ocorreu após suplementação de oxigênio. O segundo ciclo foi administrado após resolução completa do quadro, com redução da dose do quimioterápico em 30%. O paciente evoluiu de forma bastante satisfatória.
Descritores: Pneumatose Cistoide Intestinal/induzido quimicamente
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Etoposídeo/efeitos adversos
Neoplasias Pulmonares/tratamento farmacológico
Antineoplásicos Fitogênicos/efeitos adversos
-Oxigenoterapia
Pneumatose Cistoide Intestinal/terapia
Carcinoma Pulmonar de Células não Pequenas/secundário
Etoposídeo/uso terapêutico
Neoplasias Pulmonares/secundário
Antineoplásicos Fitogênicos/uso terapêutico
Limites: Humanos
Masculino
Idoso
Responsável: BR1.1 - BIREME


  8 / 97 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-623976
Autor: Zhou, Jun.
Título: Bioactive glycosides from Chinese medicines
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):231-234, 1991. ilus.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Glycosides are the bioactive components of many famous Chinese medicines. Here reported are some bioactive glycosides we discovered from Chinese medicines in recent years. (1) Pheolic glycosides from Chinese medicines: Gastrodia elata, acontium austroynanense and Helicia erratica, three bioactive phenolic glycosides were discovered and two of them have been developed into new drugs. (2) Terpenoidal glycosides: a) Monoterpenoid: the sweroside from Swertia mollensis has been developed intro an anti-hepatitis drug; b) Diterpenoid: Phlomis betonicoides contains sweet glycoides; c) Triterpenoid: many biologically active triterpenoid glycosides were isolated from Panax plants and Siraitia grosvenorii. (3) Steroidal glycosides: a) C21-steroid: Cynanchum otophyllum and C. atratrum contain anti-epilepsy and-tumor glycosides; b) C27-steroid Hemostatic saponins were found in Paris polyphylla.
Descritores: Saponinas/isolamento & purificação
Esteroides/isolamento & purificação
Esteroides/farmacologia
Edulcorantes/isolamento & purificação
Terpenos/isolamento & purificação
Terpenos/farmacologia
Medicamentos de Ervas Chinesas/química
Glicosídeos/uso terapêutico
Hepatite/tratamento farmacológico
Antineoplásicos Fitogênicos/isolamento & purificação
-Anticonvulsivantes/isolamento & purificação
Limites: Humanos
Animais
Responsável: BR1.1 - BIREME


  9 / 97 LILACS  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-623942
Autor: Oliveira, Marilda Meirelles de.
Título: Antitumor activity of chemical modified natural compounds
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):61-65, 1991. ilus, graf.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Search of new activity substances starting from chemotherapeutic agents, continously appears in international literature. Perhaps this search has been done more frequently in the field of anti-tumor chemotherapy on account of the unsuccess in saving advanced stage patients. The new point in this matter during the last decade was computer aid in planning more rational drugs. In near future "the accessibility of supercomputers and emergence of computer net systems, willopen new avenues to rational drug design" (Portoghese, P. S. J. Med. Chem. 1989, 32, 1). Unknown pharmacological active compounds synthetized by plants can be found even without this eletronic devices, as tradicional medicine has pointed out in many contries, and give rise to a new drug. These compounds used as found in nature or after chemical modifications have produced successful experimental medicaments as FAA, "flavone acetic acid" with good results as inibitors of slow growing animal tumors currently in preclinical evaluation for human treatment. In this lecture some international contributions in the field of chemical modified compounds as antineoplasic drugs will be examined, particularly those done by Brazilian researches.
Descritores: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/síntese química
Antineoplásicos Fitogênicos/química
-Brasil
Ensaios de Seleção de Medicamentos Antitumorais
Desenho de Fármacos
Avaliação de Medicamentos
Antineoplásicos
Limites: Humanos
Animais
Responsável: BR1.1 - BIREME


  10 / 97 LILACS  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo SciELO Brasil
Texto completo
Id: lil-623941
Autor: Xu, Ren-Sheng; Tang, Zong-Jian; Feng, Sheng-Chu; Yang, Yi-Ping; Lin, Wen-Han; Zhong, Qiong-Xing; Zhong, Yi.
Título: Studies on bioactive components from Chinese medicinal plants
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):55-59, 1991. ilus, tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Several novel bioactive components isolated from Chinese medicinal plants will be presented. These include novel maytansinoid tumor, inhibitors, some new ent-kaurane and rosane diterpenoids from Mallotus anomalus Meer et Chun (Euphorbiaceae), as well asnovel insecticide, stemona alkaloids from Stemona parviflora C. H. Wright (Stemonaceae). Both are native plants of Hainan island, Chine. 2D NMR techniques such as mono and hetero-COSY, NOESY, COLOC as well as H-NMR line broadening effect were utilized for structure elucidation. The separation techniques, struture elucidations and bioassay results will be reported.
Descritores: Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/química
Inseticidas/isolamento & purificação
Inseticidas/química
-Antitussígenos/isolamento & purificação
Antitussígenos/química
Medicamentos de Ervas Chinesas/uso terapêutico
Antineoplásicos
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/uso terapêutico
Limites: Animais
Camundongos
Responsável: BR1.1 - BIREME



página 1 de 10 ir para página                        
   


Refinar a pesquisa
  Base de dados : Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde