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Id: biblio-887046
Autor: Ramos, Rogério Rodrigo; Paiva, Jeferson Leandro de; Gomes, José Paulo Franco dos Santos; Boer, Nagib Pezati; Godoy, José Maria Pereira de; Batigalia, Fernando.
Título: Photodynamic action of the red laser on Propionibacterium acnes
Fonte: An. bras. dermatol;92(5):622-625, Sept.-Oct. 2017. tab, graf.
Idioma: en.
Resumo: Abstract: Background: Photodynamic therapy is a therapeutic modality that has consolidated its activity in the photooxidation of organic matter, which arises from the activity of reactive oxygen species. Objective: To evaluate the effect of red laser 660nm with the photosensitizer methylene blue on Propionibacterium acnes in vitro. Method: The experimental design was distributed into four groups (1 - control group without the application of light and without photosensitizer, 2 - application of light, 3 - methylene blue without light, and 4 - methylene blue with light). Tests were subjected to red laser irradiation 660nm by four cycles of 5 minutes at 3-minute intervals. Results: It was evidenced the prominence of the fourth cycle (20 minutes) groups 2, 3 and 4. Study limitations: Despite the favorable results, the laser irradiation time photosensitizer associated with methylene blue were not sufficient to to completely inhibit the proliferation of bacteria. Conclusion: Further studies in vitro are recommended to enable the clinical application of this photosensitizer in photodynamic therapy.
Descritores: Fotoquimioterapia/métodos
Propionibacterium acnes/efeitos dos fármacos
Fármacos Fotossensibilizantes/farmacologia
Azul de Metileno/farmacologia
-Propionibacterium acnes/efeitos da radiação
Fatores de Tempo
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-887026
Autor: Torraca, Pedro de Freitas Silva; Murback, Nathalia Dias Negrão; Wiziack, Nayara de Castro; Freitas, Tânia Christina Marchesi de; França, Greicy Mara.
Título: Segmental lichen aureus: an uncommon presentation
Fonte: An. bras. dermatol;92(5):704-706, Sept.-Oct. 2017. graf.
Idioma: en.
Resumo: Abstract: Pigmented purpuric dermatoses are chronic vascular inflammatory conditions characterized by the presence of pigmented macules. Among its different presentations, lichen aureus is distinguished by the lichenoid conformation of its plaques and the predilection for lower limb involvement. Its segmented form is rare and difficult to control, especially in cases of symptomatic lesions. We report a rare case of segmental lichen aureus with six years of evolution associated with light itching. We also discuss the main therapeutic approaches to control the disease.
Descritores: Erupções Liquenoides/patologia
-Luz Solar
Betametasona/uso terapêutico
Fármacos Fotossensibilizantes/uso terapêutico
Erupções Liquenoides/terapia
Glucocorticoides/uso terapêutico
Metoxaleno/uso terapêutico
Limites: Seres Humanos
Feminino
Meia-Idade
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-887175
Autor: Akarsu, Sevgi; Fetil, Emel; Ozbagcivan, Ozlem; Gunes, Ali Tahsin.
Título: Blocking or enhancing effects of some basic emollients in UVA penetration
Fonte: An. bras. dermatol;93(2):238-241, Mar.-Apr. 2018. tab, graf.
Idioma: en.
Resumo: Abstract: Background: Topical agents used in combination with phototherapy or photochemotherapy may have both blocking or enhancing effects in ultraviolet rays. Objective: In this in vivo study, the effects of topical petrolatum, basis cream, glycerine, and olive oil on the transmission of ultraviolet A radiation were investigated. Methods: A test was performed to determine the minimal phototoxic dose on 29 volunteers with only psoralen plus ultraviolet A (PUVA) and then the same test was repeated with white petrolatum, basis cream, glycerine, olive oil, and sunscreen (0.3cc/25cm2). The effects of each agent on the minimal phototoxic dose were determined after 72 h. Results: When compared to pure PUVA, there was a statistically significant increase in the mean minimal phototoxic dose values by the application of white petrolatum (P = 0.011), but there was no significant increase or decrease in the mean minimal phototoxic dose values after the application of basis cream (P = 0.326), glycerine (P = 0.611) or olive oil (P = 0.799). Study limitations: Low number of patients Conclusion: The application of white petrolatum, which has a blocking effect, and also of basis cream immediately before PUVA therapy should not be recommended. Although we specify that glycerine and maybe olive oil can be used before photochemotherapy, there is a need for further research in larger series.
Descritores: Vaselina/farmacologia
Fotoquimioterapia/métodos
Terapia PUVA/métodos
Dermatopatias/tratamento farmacológico
Raios Ultravioleta
Fármacos Fotossensibilizantes/farmacologia
Emolientes/farmacologia
-Protetores Solares/farmacologia
Fatores de Tempo
Testes Cutâneos
Método Simples-Cego
Reprodutibilidade dos Testes
Resultado do Tratamento
Dermatite Fototóxica/prevenção & controle
Estatísticas não Paramétricas
Relação Dose-Resposta à Radiação
Azeite de Oliva/farmacologia
Glicerol/farmacologia
Limites: Seres Humanos
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-949933
Autor: Zhang, YunJie; Lin, Hui; Guo, XiaoJuan; Zou, XianBiao.
Título: A case series pilot study on the combination of 5-aminolevulinic acid and photodynamic therapy (ALA-PDT) for treatment of vitiligo
Fonte: An. bras. dermatol;93(4):539-545, July-Aug. 2018. tab, graf.
Idioma: en.
Projeto: National Science Fund for Distinguished Young Scholars.
Resumo: Abstract: Background: To study the effective therapeutic concentration, drug application duration, irradiation duration and irradiation dosage of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) for treating vitiligo and observe its clinical efficacy. Objective: To assess the clinical efficacy of ALA-PDT for treating vitiligo. Methods: ALA with different drug concentrations, drug application durations, irradiation durations and irradiation dosages were adopted to treat skin lesions caused by vitiligo to determine the effective drug concentration, drug application duration, irradiation duration and irradiation dosage for treating three vitiligo volunteers and observe the therapeutic results. Results: The clinical trial suggested that ALA at a drug concentration of 1.5%, drug application duration for 3 hours, irradiation dosage of 80mw/cm2 and irradiation duration for 20 min was effective in treating vitiligo. Under these parameters, ALA-PDT was effective to the three vitiligo volunteers, with mild pain and feeling of burning but no other adverse reaction during treatment. Study limitations: Due to the small sample size in this study for the effectiveness of PDT in treating vitiligo and the potential variations in the efficacy for treating the disease at different areas, further studies shall be conducted for confirmation. Conclusions: ALA with a drug concentration at 1.5%, drug application duration for 3 hours, irradiation dosage of 80 mw/cm2 and irradiation duration for 20 min is effective in treating vitiligo. Therefore, ALA-PDT is safe and effective in treating the disease, with minor adverse events, providing a new method for treating vitiligo in the future.
Descritores: Fotoquimioterapia/métodos
Vitiligo/tratamento farmacológico
Fármacos Fotossensibilizantes/administração & dosagem
Ácidos Levulínicos/administração & dosagem
-Projetos Piloto
Resultado do Tratamento
Limites: Seres Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1051385
Autor: Nuernberg, Marta Aparecida Alberton.
Título: Efeito do fotossensibilizador butyl azul de toluidina na terapia fotodinâmica antimicrobiana para o tratamento da periodontite experimental em ratos / Effects of butyl toluidine blue photosensitizer on antimicrobial photodynamic therapy for experimental periodontitis treatment in rats.
Fonte: Araçatuba; s.n; 2019. 80 p. ilus, tab.
Idioma: en.
Tese: Apresentada a Universidade Estadual Paulista "Julio de Mesquita Filho". Faculdade de Odontologia de Araçatuba para obtenção do grau de Doutor.
Resumo: O presente estudo avaliou pela primeira vez "in vivo" os efeitos de três concentrações do butyl azul de toluidina (BuTB) como agente fotossensibilizador na terapia fotodinâmica antimicrobiana (aPDT), como terapia coadjuvante a raspagem e alisamento radicular (RAR), para o tratamento de periodontite experimental (PE) em ratos. A PE foi induzida por meio da instalação de um fio de algodão ao redor do primeiro molar inferior esquerdo. Posteriormente os animais foram aleatoriamente distribuídos em 7 grupos com 15 animais cada, através de uma tabela gerada por computador, de acordo com os seguintes tratamentos: RAR (n=15) - RAR seguido de irrigação local de solução salina fisiológica; BuTB-0,1 (n=15) - RAR seguido de aplicação local de BuTB na concentração de 0,1 mg/mL; aPDT-0,1 (n=15) - RAR seguido da aplicação local de BuTB na concentração de 0,1 mg/mL e irradiação com laser de diodo (LD) de InGaAlP (660 nm, 40 mW, 60 s, 2,4 J); BuTB-0,5 (n=15) ­ RAR seguido de aplicação local de BuTB na concentração de 0,5 mg/mL; aPDT-0,5 (n=15) ­ RAR seguido da aplicação local de BuTB na concentração de 0,5 mg/mL e irradiação com LD; BuTB-2,0 (n=15) - RAR seguido de aplicação local de BuTB na concentração de 2 mg/mL; aPDT-2,0 (n=15) - RAR seguido da aplicação local de BuTB na concentração de 2 mg/mL e irradiação com LD. Decorridos 7, 15 e 30 dias pós-tratamento, 5 animais de cada grupo foram submetidos à eutanásia. A área de furca dos molares foi submetida às análises histológica, histométrica e dos padrões de imunomarcação para TGF-ß1, OCN e TRAP. Os dados foram submetidos à análise estatística (α = 5%). De acordo com a análise histométrica na região de furca, todos os grupos experimentais apresentaram menor perda óssea comparado ao grupo controle. Histologicamente, os espécimes do aPDT-0,5 apresentaram uma resposta inflamatória local mais branda e menos extensa, com melhor reestruturação tecidual em todos os períodos. Aos 30 dias observou-se resolução total da resposta inflamatória local, com presença de tecido conjuntivo denso. Alguns espécimes apresentavam trabéculas ósseas com contorno regular revestido com osteoblastos ativos, incluindo áreas de neoformação óssea. O tratamento com aPDT na concentração de 0,5 mg/mL resultou em padrões mais altos de imunomarcação de TGF-ß1 em todos os períodos e de OCN aos 30 dias. Diante dos resultados obtidos, todas as concentrações do novo fotossensibilizador BuTB trouxeram resultados adicionais ao tratamento da PE em relação a RAR. No entanto, a aPDT realizada com a concentração de 0,5 mg/mL resultou em benefícios adicionais na resposta inflamatória local e melhor reestruturação tecidual(AU)

The present study evaluated for the first time the effects of three concentrations of butyl toluidine blue (BuTB) as a photosensitizing agent on antimicrobial photodynamic therapy (aPDT), as adjuvant therapy to scaling and root planing (SRP), for the treatment of experimental periodontitis (EP) in rats. EP was induced by placing a cotton thread around the lower left first molar. Subsequently, the animals were randomly distributed into seven groups with 15 animals each, through a computer generated table, according to the following treatments: SRP (n = 15), SRP followed by local irrigation of physiological saline solution; BuTB-0.1 (n = 15), SRP followed by local application of 0.1 mg/mL BuTB; aPDT-0.1 (n = 15), SRP followed by local application of BuTB at 0.1 mg/mL concentration and irradiation with InGaAlP diode laser (DL) (660 nm, 40 mW, 60 s, 4 J); BuTB-0.5 (n = 15), SRP followed by local application of BuTB at 0.5 mg/mL concentration; aPDT-0.5 (n = 15), SRP followed by local application of BuTB at 0.5 mg/mL concentration and DL irradiation; BuTB-2.0 (n = 15), SRP followed by local application of BuTB at 2 mg/mL concentration; aPDT-2.0 (n = 15), SRP followed by local application of BuTB at 2 mg/mL concentration and DL irradiation. The animals (n=5) from each group were submitted to euthanasia at 7, 15 and 30 days post-treatment. The furcation area of the first lower molar was submitted to histological, histometric and immunohistochemical analyses to identify TGF-ß1, OCN and TRAP. The data were submitted to statistical analysis (α = 5%). According to the histometric analysis in the furcation region, all experimental groups presented lower bone loss compared to the control group. Histologically, the aPDT -0.5 specimens presented a milder and less extensive local inflammatory response, with better tissue remodeling in all periods. Total resolution of the local inflammatory response was observed at 30 days with presence of mature connective tissue. Some specimens presented bone trabeculae with a regular contour and active osteoblasts, including areas of bone neoformation. Treatment with aPDT-0.5 also resulted in higher immunolabelling patterns of TGFß1 at all periods and of OCN at 30 days. All concentrations of the new photosensitizer BuTB resulted in significant improvement for EP treatment in relation to SRP. However, aPDT combined with BuTB at 0.5 mg / mL showed the best benefits for inflammatory response and periodontal repair process(AU)
Descritores: Periodontite
Fotoquimioterapia
Raspagem Dentária
-Periodontite/tratamento farmacológico
Ratos Wistar
Fármacos Fotossensibilizantes
Limites: Animais
Ratos
Responsável: BR186.1 - Biblioteca Honório Monteiro
BR186.1


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Id: lil-781356
Autor: Ramos, Rogério Rodrigo; Kozusny-Andreani, Dora Inês; Fernandes, Adjaci Uchôa; Baptista, Mauricio da Silva.
Título: Photodynamic action of protoporphyrin IX derivatives on Trichophyton rubrum
Fonte: An. bras. dermatol;91(2):135-140, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Projeto: Fapesp; . REDOXOME.
Resumo: Abstract: BACKGROUND: Dermatophytes are filamentous keratinophilic fungi. Trichophyton rubrum is a prevalent infectious agent in tineas and other skin diseases. Drug therapy is considered to be limited in the treatment of such infections, mainly due to low accessibility of the drug to the tissue attacked and development of antifungal resistance in these microorganisms. In this context, Photodynamic Therapy is presented as an alternative. OBJECTIVE: Evaluate, in vitro, the photodynamic activity of four derivatives of Protoporphyrin IX by irradiation with LED 400 nm in T. rubrum. METHOD: Assays were subjected to irradiation by twelve cycles of ten minutes at five minute intervals. RESULT: Photodynamic action appeared as effective with total elimination of UFCs from the second irradiation cycle. CONCLUSION: Studies show that the photodynamic activity on Trichophyton rubrum relates to a suitable embodiment of the photosensitizer, which can be maximized by functionalization of peripheral groups of the porphyrinic ring.
Descritores: Fotoquimioterapia/métodos
Protoporfirinas
Trichophyton/efeitos dos fármacos
Fármacos Fotossensibilizantes/farmacologia
-Valores de Referência
Fatores de Tempo
Tinha/tratamento farmacológico
Contagem de Colônia Microbiana
Reprodutibilidade dos Testes
Análise de Variância
Arthrodermataceae/efeitos dos fármacos
Antifúngicos/farmacologia
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1038244
Autor: Galvão, Luiz Eduardo Garcia; Gonçalves, Heitor de Sá; Botelho, Karine Paschoal; Caldas, Juliana Chagas.
Título: Daylight photodynamic therapy - Experience and safety in treatment of actinic keratoses of the face and scalp in low latitude and high brightness region
Fonte: An. bras. dermatol;92(1):142-144, Jan.-Feb. 2017. graf.
Idioma: en.
Resumo: ABSTRACT Daylight photodynamic therapy has been used in countries with high latitudes during the summer for actinic keratoses treatment with reports of similar efficacy to conventional photodynamic therapy. We evaluate its safety in 20 patients in the city of Fortaleza, a local with low latitude and high brightness. Sixteen patients did not report any discomfort due to the procedure. Daylight photodynamic therapy is an easy application method with great tolerability by the patient and has the possibility of being performed throughout the year in these regions. It can mean a promising tool in the control of skin cancer.
Descritores: Fotoquimioterapia/métodos
Dermatoses do Couro Cabeludo/tratamento farmacológico
Luz Solar
Dermatoses Faciais/tratamento farmacológico
Ceratose Actínica/tratamento farmacológico
-Fatores de Tempo
Resultado do Tratamento
Fármacos Fotossensibilizantes/uso terapêutico
Relação Dose-Resposta à Radiação
Ácido Aminolevulínico/análogos & derivados
Ácido Aminolevulínico/uso terapêutico
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-886948
Autor: Wang, Qian; Jiang, Can; Liu, Wei; Chen, Jin; Lin, Xinyu; Huang, Xiangning; Duan, Xiling.
Título: A new optical intra-tissue fiber irradiation ALA-PDT in the treatment of acne vulgaris in rabbit model: improved safety and tolerability
Fonte: An. bras. dermatol;92(3):350-355, May-June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Background: Photodynamic therapy with topical aminolevulinic acid (ALA-PDT) has been suggested to be effective in treatment of acne vulgaris. However, adverse events occur during and after treatment. Objectives: To compare the efficacy and tolerability of optical intra-tissue fiber irradiation (OFI) ALA-PDT versus traditional ALA-PDT in treatment of acne vulgaris in rabbit models. Methods: Twenty-five rabbits of clean grade were used. Twenty rabbits were randomly selected to establish acne model and the other five were used as control. Rabbits in model group (40 ears) were further divided into four groups (10 ears/group): I, OFI-ALA-PDT with the head of optical fiber inserted into the target lesion (intra-tissue); II, traditional ALA-PDT group; III, OFI group; IV, blank control group without any treatment. Uncomfortable symptoms, adverse events, and effectiveness rates were recorded on post-treatment day 14, 30, and 45. Results: On post-treatment day 14, the effectiveness rate in OFI-ALA-PDT group was obviously higher than that of the other three groups (P<0.05). However, no improved effects were observed in OFI-ALA-PDT group on day 30 and 45. During the period of treatment, the frequencies of uncomfortable symptoms in ALA-PDT group were obviously higher than those in the other three groups (P<0.05). The adverse event rate in OFI-ALA-PDT group was obviously lower than that of the ALA-PDT group (P<0.05) Study limitations: The unblindness of the study and temporary animal models of acne induced may hamper the assessment and monitoring of the results, and future studies are still needed to clarify it further. Conclusion: The OFI-ALA-PDT group (intra-tissue irradiation) showed no improved efficacy on treating rabbit ear acne but had higher safety and better tolerability.
Descritores: Fotoquimioterapia/métodos
Fármacos Fotossensibilizantes/administração & dosagem
Acne Vulgar/terapia
Ácido Aminolevulínico/administração & dosagem
-Fotoquimioterapia/efeitos adversos
Distribuição Aleatória
Resultado do Tratamento
Fármacos Fotossensibilizantes/efeitos adversos
Modelos Animais de Doenças
Ácido Aminolevulínico/efeitos adversos
Limites: Animais
Coelhos
Responsável: BR1.1 - BIREME


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Id: biblio-887004
Autor: Zhang, Yunjie; Jiang, Shuang; Chen, Hongxia; Zou, Xianbiao.
Título: Hemoporfin-mediated photodynamic therapy for the treatment of port-wine stain birthmarks in pediatric patients
Fonte: An. bras. dermatol;92(4):559-561, July-Aug. 2017. tab, graf.
Idioma: en.
Projeto: Clinical Scientific Research Supporting Fund of Chinese PLA General Hospital.
Resumo: Abstract: Port-wine stain is a type of common congenital superficial telangiectasia in the dermal layer mostly occurring on the forehead, face, and neck. The affected skin shows abnormal red or purple lesions, which darken and thicken. Nodular changes may develop with advancing age. If untreated, port-wine stains scarcely regress, which can have serious lifelong psychological impact on patients and affect their quality of life. In this report, we focused on two cases of port-wine stain in pediatric patients; the youngest patient was only 1.5 years old. During and after treatment, Hemoporfin-mediated photodynamic therapy features fewer adverse reactions, short light protection period, easy nursing, and good efficacy.
Descritores: Fotoquimioterapia
Fármacos Fotossensibilizantes/uso terapêutico
Mancha Vinho do Porto/tratamento farmacológico
Hematoporfirinas/uso terapêutico
Limites: Seres Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1040745
Autor: Melo, Gleice K. A; Silva, Westerlly J; Pupin, Rayane C; Heckler, Rubiane F; Nonato, Lucimara M; Ítavo, Camila C. B. F; Ferreira, Valquíria B. N; Lemos, Ricardo A. A.
Título: Comparison of two collection methods to determine protodioscin concentrations in Brachiaria spp. and to monitor Brachiaria spp. poisoning / Comparação entre dois métodos de coleta para determinar as concentrações de protodioscina em Brachiaria spp. e monitorar a intoxicação por Brachiaria spp
Fonte: Pesqui. vet. bras = Braz. j. vet. res;39(9):710-714, Sept. 2019. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: The objective of this study was to evaluate the methods of collecting Brachiaria spp. (Simulated Grazing vs. Total Collection) for the determination of protodioscin concentrations and to monitor the intoxication in sheep susceptible and resistant to poisoning by Brachiaria spp. The collection of Brachiaria spp. was done through two different methods. The first one consisted in throwing a metallic square at 10 random picket points. The second was performed simulating, with the hands, the grazing behavior of sheep. The leaf blades obtained by the two methods were conditioned in a forced ventilation oven. The extraction and quantification of protodioscin from the dry milled plant material was done by reverse-phase high-performance liquid chromatography (HPLC). The collections were carried out at three stages of the life of experimental lamb (suckling, rearing, and finishing). The lambs were divided into resistant and susceptible to intoxication by Brachiaria spp. The criterion for a lamb to be considered sensitive was to present some clinical signs at some stage of its life. No significant differences were observed between the general averages of the two collections when the evaluation was done in the whole period. However, a significant difference was found at the onset of the clinical signs. The concentrations of protodioscin in this period were higher in Brachiaria spp. collected by the simulating grazing method. Both methodologies were efficient to determine the level of protodioscin in the pastures of Brachiaria spp. However, during the periods when the outbreaks occurred, the simulated grazing method was more reliable.(AU)

Objetivou-se avaliar dois métodos de coleta de Brachiaria spp. (Pastejo Simulado vs Coleta Total) para determinação das concentrações de protodioscina e efetuar o monitoramento da intoxicação em rebanhos sensíveis e resistentes à intoxicação por Brachiaria spp. Foram realizadas coletas de Brachiaria spp. através de duas metodologias. A primeira consistiu em fazer o lançamento de um quadrado metálico em 10 pontos aleatórios do piquete. A segunda foi realizada simulando com as mãos o comportamento de pastejo dos ovinos. As lâminas foliares obtidas pelas duas metodologias foram acondicionadas em estufa de ventilação forçada. O material seco e moído foi encaminhado para extração e quantificação da protodioscina por cromatografia líquida de alto desempenho (HPLC) de fase reversa. As coletas foram realizadas em três fases de vida dos cordeiros (cria, recria e terminação). Os cordeiros foram divididos em resistentes e sensíveis a intoxicação por Brachiaria spp. O critério para o ovino ser considerado sensível foi apresentar algum sinal clínico da intoxicação em alguma fase de sua vida. Não foram observadas diferenças significativas entre a média geral das duas coletas quando a avaliação foi feita no período total. Porém, foi observada diferença significativa no período de aparecimento dos casos. As concentrações de protodioscina neste período foram superiores pelo método do pastejo simulado. Ambas as metodologias mostraram-se eficientes para determinação da concentração da protodioscina nas pastagens de Brachiaria spp. No entanto, nos períodos em que ocorreram os surtos, o método do pastejo simulado foi mais fidedigno.(AU)
Descritores: Plantas Tóxicas
Saponinas/toxicidade
Fármacos Fotossensibilizantes
Brachiaria/toxicidade
Limites: Animais
Bovinos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice



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