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Id: biblio-959889
Autor: Calderón, Álvaro; Cuéllar, Diana.
Título: PET/CT 18F-FDG en carcinomatosis peritoneal: revisión de la fisiopatología y presentación de dos casos / PET/CT 18F-FDG in peritoneal carcinomatosis: A review of the pathophysiology and a presentation of two cases
Fonte: Rev. colomb. cancerol;22(2):92-95, abr.-jun. 2018. graf.
Idioma: es.
Resumo: Resumen La carcinomatosis peritoneal corresponde a la diseminación o extensión en la cavidad peritoneal de un cáncer originado en algún órgano o viscera del abdomen, generalmente asociado a tumores digestivos o ginecológicos. También puede presentarse en forma primaria en patologías como el mesotelioma y el adenocarcinoma primario peritoneal. Las imágenes anatómicas son el pilar de la evaluación de las siembras peritoneales, pero pequeños implantes neoplásicos pueden ser difíciles de detectar con TAC o resonancia magnética. El PET/CT 18F-FDG tiene el poder de mejorar la detección de las metástasis peritoneales. Está indicado en pacientes con marcadores tumorales elevados, con imágenes anatómicas negativas o no conclusivas y en pacientes seleccionados para citorreducción completa. Se suma a las imágenes convencionales en la detección y estadificación de la carcinomatosis peritoneal, y es una herramienta diagnóstica útil en el monitoreo de la respuesta a la terapia y en el seguimiento a largo plazo.

Abstract Peritoneal carcinomatosis is the dissemination or extension in the peritoneal cavity of a cancer originated in some organ or abdominal viscera, generally associated with digestive or gynaecological neoplasms. It can also occur in primary form, as in mesothelioma and primary peritoneal adenocarcinoma. Anatomical images are essential for the evaluation of peritoneal seeding, but small neoplastic implants can be difficult to detect with CT or MR imaging. PET/CT 18F-FDG can improve the detection of peritoneal metastases. It is indicated in patients with elevated tumour markers, with negative or inconclusive anatomical images, and in patients selected for complete debulking. PET/CT 18F-FDG adds to conventional images in the detection and staging of peritoneal carcinomatosis, and is a useful diagnostic tool in monitoring the response to therapy and in long-term follow-up.
Descritores: Neoplasias Peritoneais
Terapêutica
Fluordesoxiglucose F18
-Fármacos Gastrointestinais
Espectroscopia de Ressonância Magnética
Limites: Humanos
Tipo de Publ: Relatório Técnico
Responsável: CO40.1 - Biblioteca Médica


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Martínez, Jaime
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Id: lil-564558
Autor: Arroyo, Jorge; Almora, Yuan; Quino, Mariano; Martínez, Jaime; Condorhuamán, Martín; Flores, Marlene; Bonilla, Pablo.
Título: Efecto citoprotector y antisecretor del aceite de Copaifera officinalis en lesiones gástricas inducidas en ratas / Copaifera officinalis oil cytoprotector and antisecretory effects in induced gastric lesions in rats
Fonte: An. Fac. Med. (Perú);70(2):89-96, abr.-jun. 2009. ilus, tab, graf.
Idioma: es.
Resumo: Objetivos: Demostrar el efecto gastroprotector del aceite de Copaifera officinalis usando indometacina y ligadura de píloro en ratas. Diseño: Estudio preclínico. Lugar: Facultades de Medicina, de Farmacia y Bioquímica. Universidad Nacional Mayor de SanMarcos, Lima, Perú. Material biológico: Ratas y aceite de copaiba. Intervenciones: Se colectó el aceite de copaiba en Ucayali, Pucallpa. La citoproteccción fue evaluada con indometacina, considerando un grupo control normal, indometacina, grupos deaceite de copaiba y omeprazol. Las lesiones de la mucosa gástrica fueron calificadas como las compatibles con necrosis local (tejido no viable), hiperemia, enrojecimiento presente y hemorragia, empleando la escala de puntaje observacional; y la úlcera,según la escala de Macallister modificado. El ensayo de antisecreción fue realizado por el modelo de ligadura del píloro, en el que 24 ratas albinas fueron divididas al azar en 3 grupos; un control, otro de aceite de copaiba 40mg/kg y un tercero de omeprazol10 mg/kg. Después de 4 horas de ligazón, fueron sacrificados, extrayéndose los estómagos; con mucho cuidado se midió el volumen y se determinó el pH de la secreción gástrica, por potenciometría. Se realizó evaluación histopatológica segúnDevi. Principales medidas de resultados: Lesiones ulcerosas. Resultados: Losresultados indicaron 100 por ciento de efecto citoprotector con el aceite de copaiba y de 97,8 por ciento para el omeprazol (p menor que 0,0001), ratificado con los hallazgos histopatológicos; la disminución del volumen de secreción fue 79,4 por ciento para omeprazol y 42,8 por ciento para el aceite de copaiba (p menor que 0,001), con incremento del pH. Conclusiones: En condicionesexperimentales, el aceite de copaiba fue efectivo como agente gastroprotector enratas con inducción de úlcera gástrica.

Objetives: To determine the gastroprotector effect of Copaifera officinalis oil using indomethacin and pyloric ligature in rats. Design: Preclinical study. Setting: Faculties of Medicine, Pharmacy and Biochemistry, National University of San Marcos, Lima, Peru. Biological material: Rats and copaiba oil. Interventions: Copaiba oil was collected in Ucayali, Pucallpa. Cytoprotection was tested withindomethacin considering a normal control group, and indomethacin, copaibaand omeprazole groups. Using visual analogue scale mucosa gastric injuries were referred as those compatible with local necrosis (unviable tissue), hyperemia, flushing, and hemorrhage, and ulcers according to the modified MacallisterÆs scale. The anti-secretion trial used the pyloric ligature model. Twenty-four albino rats were randomized in three groups: control, copaiba oil 40 mg/kg and omeprazole 10 mg/kg, respectively. After 4 hours of linkage, they were sacrificed. Stomachs were removed, their volume measured carefully and gastric secretion pH determined by potentiometry. DevisÆs histopathological evaluation was used. Main outcome measures: Ulcerous injuries. Results: There was 100 per centcytoprotection with copaiba oil and 97,8 per cent with omeprazole (p minor that 0,0001), ratified by histological findings. Decrease in secretion volume was 79,4 per cent for omeprazole and 42,8 per cent for copaiba oil (p minor thet 0,0001) with pH increment. Conclusions: In experimental conditions copaiba oil was effective as gastroprotective agent in gastric ulcers-induced rats.
Descritores: Fármacos Gastrointestinais
Copaiva
Úlcera Gástrica
Limites: Humanos
Animais
Ratos
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Id: lil-564595
Autor: Sanvodal, Miguel; Ayala, Salomón; Oré, Raquel; Loli, Rudi; Huamán, Oscar.
Título: Estimulación de la actividad péptica del jugo gástrico, inducida por látex de Croton palanostigma (sangre de grado) / Croton palanostigma (cangre de grado) latex-induced gastric juice peptic activity stimulation
Fonte: An. Fac. Med. (Perú);69(3):164-167, jul.-sept. 2008. ilus, tab.
Idioma: es.
Resumo: Objetivo: Determinar si la administración del látex de Croton palanostigma (sangre de grado), vía digestiva, modifica la actividad péptica de la secreción gástrica. Diseño: Estudio experimental. Institución: Centro de Investigaciónde Bioquímica y Nutrición Alberto Guzmán Barrón, Facultad de Medicina, Universidad Nacional Mayor de San Marcos. Material biológico: Ratas albinas machos adultos y sangre de grado. Métodos: Se usó 50 ratas albinas machos adultos, entre 200 y 250 g de peso, que fueron distribuidas aleatoriamente en 5 grupos, a los que se administró por vía oro-gástrica, y en dosis única, como sigue: grupo I: 0,8 mL/kg de sangre de grado; grupo II: 0,8 mL/kg de sangre de grado neutralizada; grupo III: ranitidina 50 mg/kg; grupo IV: control, con solución salina 0,9 g % (sin histamina); grupo V: control con solución salina 0,9 g %. Se realizó ligadura pilórica, por laparotomía, con anestesia de éter etílico. Se utilizó histamina, aplicada por vía subcutánea, para estimular la secreción, excepto al grupo IV. Cuatro horas después, se extrajo el jugo gástrico, se midió el volumen, el pH por potenciometría y la actividad de la pepsina, por el método de Anson modificado, expresado como ug de tirosina/mL. Principales medidas de resultados: Modificación de la actividad péptica de la secreción gástrica. Resultados: El volumen del jugo gástrico fue significativamente menor en los grupos II y III; que en los otros, entre los que no hubo diferencia estadística. El pH del grupo III (con ranitidina) fue significativamente mayor que los otros, demostrando el efecto del fármaco. La actividad péptica fue: con sangre de grado 5,34 mas 1,04; sangre de grado neutralizada 2,69 mas 1,27; grupo ranitidina 2,57 mas 0,88; el control sin histamina 3,29 mas 0,94 y control con histamina 3,58 mas 1,18. La actividad péptica fue significativamente mayor (mas 49,2%) en el grupo con sangre de grado (p < 0,01) que en los otros grupos.

Objective: To determine if Croton palanostigma (sangre de grado) oral administration modifies gastric secretion peptic activity. Design: Experimental study. Institution: Alberto Guzman Barron Biochemistry and Nutrition Research Center, Faculty of Medicine, Universidad Nacional Mayor de San Marcos. Biologic material: Adult male albino rats and sangre de grado. Methods: Fifty 200 to 250 g adult male albino rats were randomly distributed in 5 groups according to sangre de grado oro-gastric one dose administration: group I: 0,8 mL/kg of sangre de grado; group II: 0,8 mL/kg of neutralized sangre de grado; group III: ranitidine 50 mg/kg; group IV: control group with saline solution 0,9 g % (without histamine); group V: control group with saline solution 0,9 g %. Pyloric ligature by laparotomy was done under ethylic ether anesthesia. Subcutaneously applied histamine was used to stimulate secretion, except to group IV. Four hours later, gastric juice was extracted, volume was measured, pH was determined by potentiometry and pepsin activity by modified Anson method, measured as tirosine ug/mL. Main outcome measures: Gastric secretion peptic activity modification. Results: Gastric juice volume was significantly lower in groups II and III, with no statistic difference in the other groups. Group III pH (with ranitidine) was significantly higher, showing the medicine effect. Peptic activity was as follows: 5,34 more 1,04 with sangre de grado; 2,69 more 1,27 with neutralized sangre de grado; 2,57 more 0,88 the ranitidine group; 3,29 more 0,94 control group without histamine and 3,58 more 1,18 control group with histamine. Peptic activity was significantly higher (more 49,2 %) in the sangre de grado group (p < 0,01). Conclusions: There was gastic peptic activity following the oro-gastric administration of Croton palanostigma (sangre de grado), with no pH variation.
Descritores: Fármacos Gastrointestinais
Croton
Suco Gástrico
Látex
Pepsina A
-Epidemiologia Experimental
Limites: Animais
Responsável: PE1.1 - Oficina Universitária de Biblioteca


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Texto completo SciELO Brasil
Texto completo
Id: biblio-1054674
Autor: Buanaim, Ronaldo Parisi; Pereira, José Aires; Campos, Fabio Guilherme; Kotze, Paulo Gustavo; Goto, Eduardo Felipe Kim; Mendonça, Roberta Laís Silva; Kanno, Danilo Toshio; Martinez, Carlos Augusto Real.
Título: Effects of anti-TNF-α in experimental diversion colitis
Fonte: Acta cir. bras;34(10):e201901004, Oct. 2019. graf.
Idioma: en.
Projeto: CNPq.
Resumo: Abstract Purpose: To evaluate the effects of infliximab on the inflammation of the colonic mucosa devoid from fecal stream. Methods: Twenty-four rats were submitted to a Hartmann's procedure. They remained for 12 weeks with the fecal derivation to development of diversion colitis on excluded colorectal stump. After this period, they were divided into 3 groups: one group received intervention with saline (2.0 mL / week), other group infliximab at doses of 5 mg/kg/week and the other 10 mg/kg/week for five consecutively weeks. Concluded the intervention period, the animals were euthanized to remove colon segments with and without fecal stream. Colitis was diagnosed by histological analysis and the degree of inflammation by validated score. The neutrophilic infiltrate was evaluated by tissue expression of myeloperoxidase identified by immunohistochemical. The tissue content of myeloperoxidase was measured by computer-assisted image analysis. Results: The inflammatory score was high in colonic segments without fecal stream. The intervention with infliximab reduced the inflammatory score in excluded colonic segments. The content of myeloperoxidase was reduced in colonic segments of animals treated with infliximab mainly in high concentrations. Conclusion: Intervention with infliximab reduced the inflammation and the neutrophil infiltrate in colonic segments devoid of the fecal stream.
Descritores: Fármacos Gastrointestinais/farmacologia
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Colite/tratamento farmacológico
Infliximab/farmacologia
-Fatores de Tempo
Processamento de Imagem Assistida por Computador
Trânsito Gastrointestinal/efeitos dos fármacos
Imuno-Histoquímica
Reprodutibilidade dos Testes
Ratos Wistar
Colite/patologia
Colo/efeitos dos fármacos
Colo/patologia
Peroxidase/análise
Infiltração de Neutrófilos/efeitos dos fármacos
Fezes
Mucosa Intestinal/efeitos dos fármacos
Mucosa Intestinal/patologia
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-887087
Autor: Campos, Sara; Coutinho, Inês; Cardoso, José Carlos; Portela, Francisco.
Título: Metastatic Crohn's disease despite infliximab therapy
Fonte: An. bras. dermatol;92(5,supl.1):104-106, 2017. graf.
Idioma: en.
Resumo: Abstract Metastatic Crohn's disease is a rare extraintestinal manifestation of Crohn's disease. It is characterized by polymorphic skin lesions formed by non-caseating granulomas located on anatomical sites distant from the gastrointestinal tract. We report a rare case of metastatic Crohn's disease, simultaneously displaying multiple clinically heterogeneous cutaneous lesions, in a patient with previously diagnosed Crohn's disease in remission due to anti-TNF-α use. This case highlights the need for high clinical suspicion and early biopsy in the setting of a patient with Crohn's disease and persistent skin lesions, even under biologic therapy. Furthermore, it reinforces the need of monitoring of the serum level of infliximab, increasing the dose in case it is low or undetectable.
Descritores: Fármacos Gastrointestinais/uso terapêutico
Doença de Crohn/complicações
Doença de Crohn/tratamento farmacológico
Eritema/etiologia
Infliximab/uso terapêutico
-Pele/patologia
Biópsia
Doença de Crohn/patologia
Eritema/patologia
Limites: Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1018350
Autor: Universidad Nacional de Asunciòn. Instituto de Investigaciones en Ciencias de la Salud.
Título: Investigaciòn en Ciencias de la Salud en el Paraguay / -.
Fonte: Asunciòn; El Instituto, EDUNA; 1996. 3 V p.
Idioma: es.
Descritores: Adolescente
Controle de Qualidade
Doença de Chagas/diagnóstico
Doença de Chagas/enfermagem
Doença de Chagas/imunologia
Doença de Chagas/prevenção & controle
Doença de Chagas/terapia
Doenças Transmissíveis/diagnóstico
Doenças Transmissíveis/enfermagem
Doenças Transmissíveis/imunologia
Doenças Transmissíveis/patologia
Doenças Transmissíveis/transmissão
Doenças da Glândula Tireoide/cirurgia
Doenças da Glândula Tireoide/diagnóstico
Doenças da Glândula Tireoide/prevenção & controle
Doenças da Glândula Tireoide/radioterapia
Doenças do Sistema Imunitário/enfermagem
Doenças do Sistema Imunitário/imunologia
Doenças do Sistema Imunitário/prevenção & controle
Fármacos Gastrointestinais/análise
Fármacos Gastrointestinais/efeitos adversos
Genética
Nefropatias/enfermagem
Nefropatias/prevenção & controle
Nefropatias/reabilitação
Nefropatias/virologia
Saúde Pública/educação
Saúde Pública
Síndrome de Imunodeficiência Adquirida/diagnóstico
Síndrome de Imunodeficiência Adquirida/imunologia
Síndrome de Imunodeficiência Adquirida/mortalidade
Síndrome de Imunodeficiência Adquirida/sangue
Responsável: PY2.1 - Centro de Documentación
SR 614.072 Un3i


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Texto completo SciELO Brasil
Souccar, Caden
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Id: lil-623956
Autor: Gamberini, Maria T; Skorupa, L. A; Souccar, Caden; Lapa, Antonio J.
Título: Inhibition of gastric secretion by a water extract from Baccharis triptera, Mart
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):137-139, 1991. graf, tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Baccharus triptera Mart, is a widespread Compositae used in Brazilian folk medicine to treat gastrointestinal disturbances, rheumatic disease, mild fever, diabetes and as an anti-helminthic. Water extract of small branches of the plant (WE) administered to mice and rats (0.1 to 2 g/Kg, p.o) did not alter spontaneous motor activity, sleeping time induced by barbiturates or the tailflick response in mice. The extract decreased by 40 por cento the number of writhings induced by 0.8 por cento scetic acid, i.p., but did not influence paw edema induced by carrageenan or dextran in rats WE (2g/Kg, p.o.) decreased the intestinal transit of charcoal in mice by 20//. Gastric secretion in pylorus ligated rats was reduced after treatment with WE (1 and 2 g/Kg. i.p. or intraduodenal and the gastric pH was raised. The extract (1 g/Kg, p.o.) prevented gastric ulcers induced in rats by immobilization at 4ºC, but not those induced by indomethacin (10 mg/Kg, s.c.). The results indicate that WE may relieve gastrointestinal disorders by reducing acid secretion and gastrointestinal hiperactivity. Neither analgesic nor anti-inflammatory activities were detectable. .
Descritores: Parassimpatolíticos/farmacologia
Fármacos Gastrointestinais/farmacologia
Extratos Vegetais/farmacologia
Mucosa Gástrica/efeitos dos fármacos
Mucosa Gástrica/metabolismo
Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Antidiarreicos/farmacologia
-Sono/efeitos dos fármacos
Brasil
Avaliação de Medicamentos
Limites: Animais
Masculino
Feminino
Camundongos
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1007484
Autor: Collia Avila, Karina; Graziano, Alfredo; Gutierrez, Alejandro; Lumi, Carlos Miguel.
Título: Capítulo 8. Indicaciones quirúrgicas en la urgencia / Chapter 8. Emergency indications in the emergency
Fonte: Rev. argent. coloproctología;28(1):68-74, Sept. 2017. graf, ilus, tab.
Idioma: es.
Conferência: Apresentado em: Congreso Argentino de Coloproctología, 42, Ciudad Autónoma de Buenos Aires, Sept. 2017.
Descritores: Procedimentos Cirúrgicos do Sistema Digestório/métodos
Colite Ulcerativa/cirurgia
Colite Ulcerativa/terapia
Procedimentos Cirúrgicos Eletivos
-Reoperação/métodos
Fármacos Gastrointestinais/uso terapêutico
Cuidados Pré-Operatórios
Colite Ulcerativa/epidemiologia
Morbidade
Mortalidade
Laparoscopia/métodos
Terapia Combinada
Tratamento de Emergência
Megacolo Tóxico
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Estudo Comparativo
Responsável: AR1.1 - Biblioteca Rafael Herrera Vegas


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Texto completo
Texto completo
Id: biblio-889409
Autor: Porwal, Amit; Dwivedi, Harinath; Pathak, Kamla.
Título: Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy
Fonte: Braz. J. Pharm. Sci. (Online);53(3):e00173, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT The limitations in absorption of drugs with narrow absorption window, or those unstable in the intestinal pH or those exhibiting low solubility at high pH are primary candidates for gastroretentive drug delivery systems (GRDDS). The delivery system has been widely explored for its commercial potential for a wide variety of therapeutic agents. GRDDS offer clinical therapeutics for acute and chronic management. Hypertension is a chronic disease that requires long term treatment and its management by patient compliant dosage forms would be clinically useful. Antihypertensives belonging to different classes have proved good candidates for the formulation of GRDDS. The review aims to discuss various GRDDS researched for antihypertensive drugs to increase the gastric residing time, bioavailability, henceforth to reduce the dose of the drug, dosing frequency and increase patient compliance. It also explores various marketed products and the patents filed/granted for GRRDS of antihypertensives. The GRDDS investigated include effervescent and non-effervescent floating drug delivery systems, swelling and expanding systems and bio/mucoadhesive systems. Many other systems that provided research platforms include high density systems, raft forming systems and osmotic delivery systems. In clinical context, wherein combination of antihypertensives is indicated, dual release delivery systems may also be explored.
Descritores: Sistemas de Liberação de Medicamentos
-Fármacos Gastrointestinais
Preparações Farmacêuticas
Anti-Hipertensivos/farmacologia
Tipo de Publ: Revisão
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Texto completo SciELO Cuba
Texto completo
Id: lil-779731
Autor: Ravelo Calzado, Yazmin; Molina Cuevas, Vivian; Carbajal Quintana, Daisy; Más Ferreiro, Rosa; Zamora Rodríguez, Zullyt.
Título: Gastroprotective effects of D-002 (beeswax alcohols) and Lyprinol® on experimentally-induced gastric ulceration in rats
Fonte: Rev. cuba. farm;49(3):0-0, jul.-set. 2015. tab.
Idioma: en.
Resumo: Introduction: D-002, a mixture of beeswax alcohols, has been effective in osteoarthritis models and for reducing osteoarthritis symptoms. Unlike the classic anti-inflammatory drugs, D-002 elicits gastroprotective rather than gastrotoxic effects. Lyprinol, used for ameliorating inflammation and arthritic symptoms, improves gastrointestinal dysfunction symptoms in osteoarthritis subjects. Both D-002 and Lyprinol inhibit cyclooxygenase and 5?lipoxygenase activities, and have been similarly effective for reducing inflammation experimentally. Objective: to compare the effects of D-002 and Lyprinol on gastric mucosa of normal and experimentally-induced ulcer rats. Methods: ulcer indexes were measured in normal rats and in rats with ethanol or pylorus ligation-induced ulcers, in which gastric volume and mucus secretion were also measured. Normal rats were randomized into a vehicle control, one acetic salicylic acid (150 mg/kg), three D-002, three Lyprinol groups; rats with ethanol-ulcers into a vehicle control, three D-002 and three Lyprinol-treated groups; and the experiment on pylorus ligation included a negative control and eight pylorus-ligated groups: one vehicle control, three D-002, three Lyprinol, one omeprazole 10 mg/kg. In all cases, D-002 and Lyprinol (50, 200 and 400 mg/kg) were given orally. Results: unlike D-002 and Lyprinol (50-400 mg/kg), acetic salicylic acid increased ulcer indexes and the incidence of ulcers versus the vehicle control. Single oral doses of D-002 (50-400 mg/kg) or Lyprinol (200 and 400 mg/kg) decreased significantly (p<0.01) and in a similar way ulcer indexes versus the ethanol-positive control. D-002 and Lyprinol (50-400 mg/kg) lowered significantly (p<0.01) and comparably ulcer indexes in rats with pylorus ligation versus the positive controls. D-002 (200 and 400 mg/kg) decreased gastric volume and increased gastric mucus secretion versus the positive control whereas only Lyprinol 400 mg/kg increased the gastric mucus secretion but without modifying the gastric volume. Omeprazole significantly reduced ulcer index (p<0.05) and gastric volume (p< 0.01), with no change in mucus secretion. Conclusion: D-002 and Lyprinol did not show gastrotoxic effects and similar efficacy in protecting against ethanol and pylorus ligation-induced gastric ulceration in rats(AU)

Introducción: el Dâ€'002, una mezcla de alcoholes de la cera de abejas, efectivo en modelos de osteoartritis y para reducir los síntomas de la misma. A diferencia de los medicamentos antiinflamatorios clásicos el Dâ€'002 produce efectos gastroprotectores más que efectos gastrotóxicos. El Lyprinol, usado para disminuir la inflamación y los síntomas artríticos, mejora los síntomas de disfunción gastrointestinal en sujetos con dicha enfermedad. Dâ€'002 y Lyprinol inhiben las actividades de cyclooxigenasa y 5â€'lipooxigenasa, y son similarmente efectivos para reducir la inflamación en modelos experimentales. Objetivo: comparar los efectos del Dâ€'002 y el Lyprinol sobre la mucosa gástrica de ratas normales y de ratas con úlcera gástrica inducida experimentalmente. Métodos: se determinó el índice de úlcera en ratas normales y en ratas con úlceras gástricas inducidas por etanol e inducidas por ligadura de píloro, en las cuales se midió el volumen gástrico y la secreción de mucus. Las ratas normales se distribuyeron en un grupo control (vehículo), uno con ácido acetil salicílico (150 mg/kg), tres con Dâ€'002 y tres con Lyprinol; las ratas con úlcera inducida por etanol en un grupo control (vehículo), tres con Dâ€'002 y tres con Lyprinol; y el experimento con ligadura de píloro en un grupo control (vehículo), tres Dâ€'002, tres Lyprinol y uno con omeprazol (10 mg/kg). En todos los casos, el Dâ€'002 y el Lyprinol (50, 200 y 400 mg/kg) se administraron por vía oral. Resultados: el ácido acetil salicílico, no el Dâ€'002 ni el Lyprinol (50â€'400 mg/kg), incrementó el índice de úlceras y la incidencia de úlceras comparadas con el grupo control. Dosis orales únicas de Dâ€'002 (50â€'400 mg/kg) o Lyprinol (200 y 400 mg/kg) redujeron significativa (p<0,01) y similarmente el índice de úlceras comparado con el grupo control positivo con úlceras por etanol. El Dâ€'002 y el Lyprinol (50â€'400 mg/kg) redujeron significativamente (p<0,01) y comparablemente el índice de úlceras en ratas con ligadura de píloro comparado con el grupo control positivo. El Dâ€'002 (200 y 400 mg/kg) redujo el volumen gástrico e incrementó la secreción de mucus gástrico respecto al grupo control positivo; mientras solo el Lyprinol 400 mg/kg aumentó la secreción de mucus gástrico pero sin modificar el volumen gástrico. El omeprazol redujo significativamente el índice de úlcera (p<0,05) y el volumen gástrico (p<0,01), sin modificar la secreción de mucus. Conclusiones: el Dâ€'002 y el Lyprinol no presentaron efectos gastrotóxicos, y protegieron con eficacia similar de las úlceras gástricas inducidas por etanol y por ligadura del píloro en ratas(AU)
Descritores: Úlcera Gástrica/complicações
Fármacos Gastrointestinais/uso terapêutico
Aspirina/efeitos adversos
Etanol/toxicidade
Limites: Ratos
Responsável: CU1.1 - Biblioteca Médica Nacional



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