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Id: biblio-1089101
Autor: Angarita Sierra, Teddy; Montañez Méndez, Alejandro; Toro Sánchez, Tatiana; Rodríguez Vargas, Ariadna.
Título: A case of envenomation by the false fer-de-lance snake Leptodeira annulata (Linnaeus, 1758) in the department of La Guajira, Colombia / Un caso de envenenamiento por mordedura de una serpiente falsa cabeza de lanza, Leptodeira annulata (Linnaeus, 1758), en el departamento de La Guajira, Colombia
Fonte: Biomédica (Bogotá);40(1):20-26, ene.-mar. 2020. graf.
Idioma: en.
Resumo: Envenomations by colubrid snakes in Colombia are poorly known, consequently, the clinical relevance of these species in snakebite accidents has been historically underestimated. Herein, we report the first case of envenomation by opisthoglyphous snakes in Colombia occurred under fieldwork conditions at the municipality of Distracción, in the department of La Guajira. A female biologist was bitten on the index finger knuckle of her right hand when she tried to handle a false fer-de-lance snake (Leptodeira annulata). Ten minutes after the snakebite, the patient started to have symptoms of mild local envenomation such as edema, itching, and pain in the wound. After 40 minutes, the edema reached its maximum extension covering the dorsal surface of the right hand and causing complete loss of mobility. The clinical treatment focused on pain and swelling control. No laboratory tests were performed. The patient showed good progress with the total regression of the edema 120 hours after the snake-bite accident and complete recovery of the movement of the limb in one week. Venomous bites of "non-venomous snakes" (opisthoglyphous colubrid snakes) must be considered as a significant public health problem because patients lose their work capability during hours or even days and they are forced to seek medical assistance to treat the envenomation manifestations.

Los envenenamientos por colúbridos en Colombia son poco conocidos, por lo que la relevancia clínica de estas especies de serpientes en los accidentes ofídicos ha sido históricamente subestimada. Se presenta el primer caso de envenenamiento por una serpiente opistoglifa en Colombia, ocurrido bajo condiciones de trabajo de campo en el municipio de Distracción, departamento de La Guajira. Una bióloga fue mordida en el nudillo del dedo índice de la mano derecha cuando trató de manipular una falsa cabeza de lanza o falsa mapanare (Leptodeira annulata). Diez minutos después de la mordedura de la serpiente, la paciente presentó síntomas de envenenamiento local leve, como edema, picazón y dolor en la herida. Después de 40 minutos, el edema alcanzó su extensión máxima, cubriendo la superficie dorsal de la mano derecha y causando la pérdida completa de la movilidad. El tratamiento clínico se centró en el control del dolor y la inflamación. No se hicieron pruebas de laboratorio. La paciente tuvo una buena evolución, con la regresión total del edema 120 horas después del accidente ofídico y la normalización de los movimientos de la extremidad a la semana. Las mordeduras venenosas de serpientes "no venenosas" (serpientes colúbridas opistoglifas) deben considerarse un problema de salud pública importante, ya que los pacientes pierden la capacidad de trabajo durante horas o días y se ven obligados a buscar asistencia médica para contrarrestar las manifestaciones locales de envenenamiento.
Descritores: Mordeduras de Serpentes
-Venenos
Colômbia
Colubridae
Edema
Tipo de Publ: Relatos de Casos
Responsável: CO42.1 - Biblioteca Nacional de Salud José Celestino Mutis


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Id: biblio-1392158
Autor: Berrouet, MC; Zuluaga, M; Castaño, M.
Título: Manifestaciones cardiovasculares y síndrome compartimental asociado a mordedura por Phoneutria spp: Reporte de un caso / Cardiovascular manifestations and compartment syndrome associated with bite by Phoneutria spp: case report / Manifestações cardiovasculares e síndrome compartimental associadas à mordida de Phoneutria spp: Relato de caso
Fonte: Medicina UPB;41(2):161-165, julio-diciembre 2022. ilus.
Idioma: es.
Resumo: Se describen las características sobre el phoneutrismo a propósito de un caso. El phoneutrismo es el término con el que se conoce al accidente ocasionado por la mordedura de la araña phoneutria spp, la cual tiene una relevancia clínica dada por las características tóxicas de su veneno. Se presenta un caso de mordedura de la araña phoneutria spp de un paciente atendido en un hospital de alta complejidad de la ciudad de Medellín, Colombia, con manifestaciones cardiovasculares y hallazgos compatibles con un síndrome compartimental, lo cual es inusual en este tipo de arañas, por lo que se necesitó vigilancia en unidad de alta dependencia y fasciotomía cutánea. En Colombia este tipo de accidentes no son de reporte obligatorio, por tanto existe un alto riesgo de subregistro. Lo llamativo de este caso está en las manifestaciones cardiovasculares y la presencia de síndrome compartimental que no se ha descrito en la literatura con este subespecie de arañas.

The characteristics of phoneutrism are described in relation to a case. Phoneutrism is the term with which the accident caused by the bite of the phoneutria spp spider is known, which has clinical relevance given by the toxic characteristics of its venom. We present a case of a bite by the phoneutria spp spider in a patient treated at a high-complexity hospital in the city of Medellín, Colombia, with cardiovascular manifestations and findings compatible with compartment syndrome, which is unusual in this type of spiders, and required surveillance in a high dependency unit and cutaneous fasciotomy. In Colombia reporting this type of accident is not mandatory; therefore, there is a high risk of underreporting. What is striking about this case is the cardiovascular manifestations and the presence of compartment syndrome that has not been described in the literatura with this genre of spiders.

As características do fonutrismo são descritas em um relatório de um caso. Fonutrismo é o termo usado para descrever o acidente causado pela mordida da aranha Phoneutria spp, que é clinicamente relevante devido às características tóxicas de seu veneno. Apresentamos um caso de mordida de aranha por uma aranha Phoneutria em um paciente tratado em um hospital de alta complexidade na cidade de Medellín, Colômbia, com manifestações cardiovasculares e achados compatíveis com a síndrome compartimental, o que é incomum neste tipo de aranha, exigindo vigilância em uma unidade de alta de-pendência e fasciotomia cutânea. Na Colômbia, este tipo de acidente não é obrigatório, portanto, há um alto risco de subnotificação. O que é impressionante neste caso são as manifestações cardiovasculares e a presença da síndrome compartimental, que não foi descrita na literatura com esta subespécie de aranha.
Descritores: Aranhas
-Venenos
Peçonhas
Mordeduras e Picadas
Fasciotomia
Limites: Humanos
Animais
Tipo de Publ: Relatos de Casos
Responsável: CO101.1 - BCdeS - Biblioteca Ciencias de la Salud


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Id: biblio-1371844
Autor: Hormazábal A, Nicolás; Yzoard A, Marcia; Bustos B, Raúl; Müller-Ramírez, Claudio.
Título: Estudio retrospectivo de pacientes intoxicados admitidos en la unidad de cuidados intensivos pediátricos de un hospital en Chile / Retrospective study of poisoned patients admitted to a hospital's pediatric intensive care unit in Chile
Fonte: Arch. argent. pediatr;120(4):257-263, Agosto 2022. tab.
Idioma: en; es.
Resumo: Introducción. Las intoxicaciones pediátricas son un problema de salud pública a nivel mundial. El objetivo de este estudio fue caracterizar las intoxicaciones pediátricas que fueron atendidas en la unidad de cuidados intensivos pediátricos (UCIP) de un hospital en Chile. Población y métodos. Se revisaron las fichas clínicas de pacientes diagnosticados con intoxicación e ingresados a la UCIP entre los años 2013 y 2017. Resultados. Un total de 105 casos fueron identificados, lo que representa un 3 % del total de ingresos registrados en el período estudiado. La mediana de edad de los pacientes resultó ser de 10 años. El 73,3 % de los casos correspondieron a pacientes de sexo femenino. El 51 % de los casos se asociaron a intoxicaciones intencionales y el 83 % fue causado por exposición a medicamentos. Los medicamentos identificados con mayor frecuencia fueron los antidepresivos (11,2 %), analgésicos no esteroides (10,7 %). La ingesta fue la vía de exposición más común (93 %). El promedio de estadía de los pacientes en UCIP fue de 1,3 días. Dos pacientes ingresaron en la UCI: uno requirió intubación y otro hemodiálisis. Se determinaron relaciones estadísticamente significativas entre el sexo del paciente y la circunstancia de exposición, y entre la condición psiquiátrica del paciente y el número de sustancias tóxicas ingeridas. Conclusión. La mayoría de las intoxicaciones atendidas en la UCIP fueron intencionales y correspondieron a pacientes de sexo femenino, a quienes se les asoció alguna patología psiquiátrica. Los grupos de medicamentos identificados con mayor frecuencia fueron los antidepresivos y los antiinflamatorios no esteroides.

Introduction. Pediatric poisoning is a public health problem worldwide. The objective of this study was to establish the characteristics of pediatric cases of poisoning seen at the pediatric intensive care unit (PICU) of a hospital in Chile. Population and methods. The medical records of patients diagnosed with poisoning and admitted to the PICU between 2013 and 2017 were reviewed. Results. A total of 105 cases were identified, who account for 3% of all admissions recorded in the study period. Patients' median age was 10 years. In total, 73.3% of cases were female patients; 51% of cases were associated with intentional poisoning; and 83% were caused by drug exposure. The most common drugs identified were antidepressants (11.2%) and non-steroidal anti-inflammatory drugs (10.7%). Intake was the most frequent route of exposure (93%). The average length of stay in the PICU was 1.3 days. One patient required intubation and another required hemodialysis in the PICU. Statistically significant relationships were established between patient sex and the circumstance of exposure and between the patient's psychiatric condition and the number of toxic substances ingested. Conclusion. Most poisoning cases seen at the PICU were intentional and occurred in female patients, who had a psychiatric condition. The most common drugs identified were antidepressants and non-steroidal antiinflammatory drugs.
Descritores: Venenos
-Unidades de Terapia Intensiva Pediátrica
Chile/epidemiologia
Estudos Retrospectivos
Hospitais
Anti-Inflamatórios
Antidepressivos
Limites: Humanos
Recém-Nascido
Lactente
Pré-Escolar
Criança
Adolescente
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: lil-784928
Autor: Márquez Gómez, Marco Antonio; Gómez Díaz, Graciela María.
Título: Accidente ofídico en el departamento de Sucre, Colombia / Ophidic accident in the department of Sucre, Colombia
Fonte: NOVA publ. cient;13(24):39-46, July-Dec. 2015.
Idioma: es.
Resumo: Objetivo: Describir el comportamiento del accidente ofídico en el departamento de Sucre. Métodos: Se realizó un estudio descriptivo y retrospectivo, en el cual se analizaron 803 reportes de accidentes ofídicos notificados al sistema de vigilancia epidemiologia del departamento de Sucre, durante los años 2007 a 2012, la información fue suministrada por la dirección de salud pública de la secretaria de salud del departamento de Sucre, en formato Excel©, descargada directamente del aplicativo SIVIGILA. Los datos obtenidos se analizaron estadísticamente empleando medidas de tendencia central. Resultados: En el 48.2% de los casos, el género Bothrops se identificó como el agente agresor y en el 83.9% de los casos la mordedura se localizó en las extremidades del paciente. En 356 casos equivalentes al 44% el paciente no fue hospitalizado o no se consignó esta información en la ficha. En el tratamiento de los casos hospitalizados se empleó un promedio de 4.3 ± 4.5 viales por paciente; estos datos son consistentes con el protocolo para casos leves registrados (n=450), pero al revisar los casos individuales se encontró que 228 pacientes solo recibieron entre 1 y 3 ampollas. En 84 casos solo se administró un vial.

Objective: Describe the behavior of ophidic accident in the department of Sucre. Methods: A descriptive, retrospective study was done from 2007 to 2012, in this study, 803 cases of snakebites were reported to the surveillance system of the epidemiology department of Sucre. In this department, the snakebite accidents occurs along the entire year, mainly affecting men 15 to 44 years. Those affected come from all municipalities in the department and around the rural area, and it is mainly engaged in agriculture and domestic work; however, the town of Sincelejo accounts for 28.8% of all notifications. Results: In 48.2% of cases, the genus Bothrops was identified as the offending agent and in 83.9% of cases, the bite was found in the patient's limbs. In 356 cases or 44% the patients were hospitalized or the information of this records were not found. The treatment of hospitalized cases averaged 4.3 ± 4.5 shots were used per patient; This data is consistent with the protocol for registered mild cases (n = 450), but reviewing individual cases; then, it was found that 228 patients received only 1 to 3 ampoules. In 84 cases only one shot was administered.
Descritores: Mordeduras de Serpentes
-Venenos
Toxicologia
Mortalidade
Limites: Humanos
Responsável: CO332 - Facultad de Medicina


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Id: biblio-954750
Autor: Anjolette, Fernando A. P; Leite, Flávia P; Bordon, Karla C. F; Azzolini, Ana Elisa C. S; Pereira, Juliana C; Pereira-Crott, Luciana S; Arantes, Eliane C.
Título: Biological characterization of compounds from Rhinella schneideri poison that act on the complement system
Fonte: J. venom. anim. toxins incl. trop. dis;21:25, 31/03/2015. graf.
Idioma: en.
Projeto: FAPESP; . NAP-TOXAN-USP; . CNPq.
Resumo: Background The skin secretions of toads of the family Bufonidae contain biogenic amines, alkaloids, steroids (bufotoxins), bufodienolides (bufogenin), peptides and proteins. The poison of Rhinella schneideri, formerly classified as Bufo paracnemis, presents components that act on different biological systems, including the complement system. The aim of this study was to isolate and examine the activity ofRhinella schneideri poison (RsP) components on the complement system.Methods The components active on the complement system were purified in three chromatographic steps, using a combination of cation-exchange, anion-exchange and gel filtration chromatography. The resulting fractions were analyzed by SDS-PAGE and screened for their activity in the hemolytic assay of the classical/lectin complement pathways. Fractions active on the complement system were also assessed for their ability to generate C3 fragments evaluated by two dimensional immunoelectrophoresis assay, C3a and C5a by neutrophil chemotaxis assay and SC5b-9 complex by ELISA assay.Results The fractionation protocol was able to isolate the component S5 from theRsP, as demonstrated by SDS-PAGE and the RP-FPLC profile. S5 is a protein of about 6000 Da, while S2 presents components of higher molecular mass (40,000 to 50,000 Da). Fractions S2 and S5 attenuated the hemolytic activity of the classical/lectin pathways after preincubation with normal human serum. Both components stimulated complement-dependent neutrophil chemotaxis and the production of C3 fragments, as shown by two-dimensional immunoelectrophoresis. S2 showed a higher capacity to generate the SC5b- 9 complex than the other fractions. This action was observed after the exposure of normal human serum to the fractions.Conclusions This is the first study to examine the activity of RsP components on the complement system. Fractions S2 and S5 reduced the complement hemolytic activity, stimulated complement-dependent neutrophil chemotaxis and stimulated the production of C3 fragments, indicating that they were able to activate the complement cascade. Furthermore, fraction S2 was also able to generate the SC5b-9 complex. These components may be useful tools for studying dysfunction of the complement cascade.(AU)
Descritores: Venenos
Produtos Biológicos
Bufonidae
Quimiotaxia
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Bochner, Rosany
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Id: biblio-954778
Autor: Bochner, Rosany.
Título: Paths to the discovery of antivenom serotherapy in France
Fonte: J. venom. anim. toxins incl. trop. dis;22:20, 2016.
Idioma: en.
Resumo: The current study presents a descriptive chronological survey of the articles published by Césaire Auguste Phisalix and Albert Calmette on snake poison, with the aim of shedding a light on the areas of research and reasoning followed by these scientists, leading up to their simultaneous discovery of antivenom serotherapy in 1894. The path taken by Phisalix is revealed in 15 articles that demonstrate the motivation of a naturalist and the way he confronted the puzzle of immunity against snake venom. In the case of Calmette, two articles preceded the discovery; microbiology was his theoretical base and the Pasteurian spirit of solving health problems his driving force. These two researchers followed distinct paths, mobilized by different motivations, but produced one single result. It is incontestable that the discovery of antivenom serotherapy was the work of two groups of researchers who deserve equal recognition, but who, in fact, did not receive it. Following the discovery both Calmette and Phisalix returned to their previous motivations. Calmette put the discovery into practice and began to produce antivenom serum in Lille. He came to be generally considered as the sole discoverer of antivenom serotherapy and was the recipient of a number of prestigious prizes. Phisalix, on the other hand, received little recognition and returned to his original interests, devoting himself to research on natural immunity. In Brazil, the discovery of antivenom serum therapy had a profound impact on the work of Vital Brazil Mineiro da Campanha, a researcher known worldwide for his scientific discoveries and for the evidence of the specificity of antivenom serums.(AU)
Descritores: Venenos
Antivenenos
Inquéritos e Questionários
Soro
-Microbiologia
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1249451
Autor: Paumgartten, Francisco José Roma.
Título: On the health risks of "hidden poisons on our table", good agricultural practices, pesticide residues in food, and dietary exposure assessments / Sobre os riscos para a saúde dos "venenos ocultos na nossa mesa", boas práticas agrícolas, resíduos de pesticidas nos alimentos e avaliação de exposição alimentar / Sobre los riesgos de salud de "los venenos escondidos en nuestra mesa", buenas prácticas agrícolas, residuos de pesticidas en la comida y evaluación de la exposición dietética
Fonte: Cad. Saúde Pública (Online);37(5):e00062221, 2021.
Idioma: en.
Descritores: Praguicidas/toxicidade
Venenos
Resíduos de Praguicidas/análise
Resíduos de Praguicidas/toxicidade
-Brasil
Exposição Dietética
Limites: Humanos
Tipo de Publ: Comentário
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-954815
Autor: Melani, Rafael D; Nogueira, Fabio C. S; Domont, Gilberto B.
Título: It is time for top-down venomics
Fonte: J. venom. anim. toxins incl. trop. dis;23:44, 2017. graf, ilus.
Idioma: en.
Projeto: National Council for Scientific and Technological Development; . FAPERJ; . National Council for Scientific and Technological Development.
Resumo: The protein composition of animal venoms is usually determined by peptide-centric proteomics approaches (bottom-up proteomics). However, this technique cannot, in most cases, distinguish among toxin proteoforms, herein called toxiforms, because of the protein inference problem. Top-down proteomics (TDP) analyzes intact proteins without digestion and provides high quality data to identify and characterize toxiforms. Denaturing top-down proteomics is the most disseminated subarea of TDP, which performs qualitative and quantitative analyzes of proteoforms up to ~30 kDa in high-throughput and automated fashion. On the other hand, native top-down proteomics provides access to information on large proteins (> 50 kDA) and protein interactions preserving non-covalent bonds and physiological complex stoichiometry. The use of native and denaturing top-down venomics introduced novel and useful techniques to toxinology, allowing an unprecedented characterization of venom proteins and protein complexes at the toxiform level. The collected data contribute to a deep understanding of venom natural history, open new possibilities to study the toxin evolution, and help in the development of better biotherapeutics.(AU)
Descritores: Peptídeos
Venenos/imunologia
Toxicologia
Proteômica
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-954807
Autor: Mata, Élida Cleyse Gomes da; Mourão, Caroline Barbosa Farias; Rangel, Marisa; Schwartz, Elisabeth Ferroni.
Título: Antiviral activity of animal venom peptides and related compounds
Fonte: J. venom. anim. toxins incl. trop. dis;23:3, 2017. tab, graf.
Idioma: en.
Projeto: CAPES; . CAPES; . CAPES.
Resumo: Viruses exhibit rapid mutational capacity to trick and infect host cells, sometimes assisted through virus-coded peptides that counteract host cellular immune defense. Although a large number of compounds have been identified as inhibiting various viral infections and disease progression, it is urgent to achieve the discovery of more effective agents. Furthermore, proportionally to the great variety of diseases caused by viruses, very few viral vaccines are available, and not all are efficient. Thus, new antiviral substances obtained from natural products have been prospected, including those derived from venomous animals. Venoms are complex mixtures of hundreds of molecules, mostly peptides, that present a large array of biological activities and evolved to putatively target the biochemical machinery of different pathogens or host cellular structures. In addition, non-venomous compounds, such as some body fluids of invertebrate organisms, exhibit antiviral activity. This review provides a panorama of peptides described from animal venoms that present antiviral activity, thereby reinforcing them as important tools for the development of new therapeutic drugs.(AU)
Descritores: Antivirais
Peptídeos
Venenos
-Produtos Biológicos
Fauna Marinha/análise
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-954847
Autor: Calvete, Juan J; Petras, Daniel; Calderón-Celis, Francisco; Lomonte, Bruno; Encinar, Jorge Ruiz; Sanz-Medel, Alfredo.
Título: Protein-species quantitative venomics: looking through a crystal ball
Fonte: J. venom. anim. toxins incl. trop. dis;23:27, 2017. graf, ilus.
Idioma: en.
Resumo: In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term "protein species" is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics "Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts" published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflects the authors' view of the immediate future in this direction for the proteomic analysis of venoms, particularly of snakes.(AU)
Descritores: Venenos/análise
Proteoma
Proteômica
-Serpentes
Espectrometria de Massas
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice



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