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Id: biblio-1171766
Autor: de Oliveira Kelly M P; dos S Júlio Péricles D; Grisolia Alexéia B.
Título: Antimicrobial susceptibility profile of Pseudomonas spp. isolated from a swine slaughterhouse in Dourados, Mato Grosso do Sul State, Brazil / Antimicrobial susceptibility profile of Pseudomonas spp. isolated from a swine slaughterhouse in Dourados, Mato Grosso do Sul State, Brazil.
Fonte: Rev. argent. microbiol;45(1):57-60, mar. 2013.
Idioma: es.
Resumo: The present work sought to detect the presence of Pseudomonas spp. at different stages of an effluent treatment plant using the Australian system of stabilization ponds, and to determine the susceptibility of those isolates to different antimicrobials. Thirty-four isolates of Pseudomonas spp. derived from effluent treatment station water samples were collected near the transfer ducts between the ponds in November/2008 and december/2009. Among the Pseudomonas spp. isolates, 47.05

showed susceptibility to all antimicrobials tested, 20.58

were resistant to cefepime, and 24

showed intermediate resistance to streptomycin. No Pseudomonas spp. isolates were found in the final pond, or in post-treatment effluents. The Pseudomonas spp. isolates did not exhibit multiresistance to the antimicrobials tested.
Descritores: Matadouros
Pseudomonas/efeitos dos fármacos
Resistência Microbiana a Medicamentos
Sus scrofa/microbiologia
-Animais
Antibacterianos/farmacologia
Brasil
Eliminação de Resíduos Líquidos/métodos
Eliminação de Resíduos de Serviços de Saúde/métodos
Especificidade da Espécie
Estudos Retrospectivos
Microbiologia da Água
Pseudomonas/classificação
Pseudomonas/isolamento & purificação
Resíduos Industriais
Suínos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Águas Residuárias/microbiologia
Tipo de Publ: Artigo de Revista
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Research Support, Non-U.S. Gov't
Responsável: AR5.1 - Centro de Gestión del Conocimiento y las Comunicaciónes


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Id: lil-780802
Autor: Akturk, Hacer; Sutcu, Murat; Somer, Ayper; Aydın, Derya; Cihan, Rukiye; Ozdemir, Aslı; Coban, Asuman; Ince, Zeynep; Citak, Agop; Salman, Nuran.
Título: Carbapenem-resistant Klebsiella pneumoniae colonization in pediatric and neonatal intensive care units: risk factors for progression to infection
Fonte: Braz. j. infect. dis;20(2):134-140, Mar.-Apr. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Background Little is known about factors associated with carbapenem-resistant Klebsiella pneumoniae infections in pediatric patients, who are initally colonized with carbapenem-resistant Klebsiella pneumoniae. Materials and methods A retrospective case–control study was conducted involving pediatric and neonatal intensive care units throughout a five-year period (January 2010–December 2014). Clinical and microbiological data were extracted from Hospital Infection Control Committee reports and patients’ medical records. Risk factors were assessed in carbapenem-resistant Klebsiella pneumoniae colonized patients who developed subsequent systemic infection (cases) and compared to carbapenem-resistant Klebsiella pneumoniae colonized patients who did not develop infection (controls). Results Throughout the study period, 2.6% of patients admitted to neonatal intensive care units and 3.6% of patients admitted to pediatric intensive care units had become colonized with carbapenem-resistant Klebsiella pneumoniae. After a mean of 10.6 ± 1.9 days (median: 7 days, range: 2–38 days) following detection of colonization, 39.0% of the carbapenem-resistant Klebsiella pneumoniae colonized patients in pediatric intensive care units and 18.1% of carbapenem-resistant Klebsiella pneumoniae colonized patients in neonatal intensive care units developed systemic carbapenem-resistant Klebsiella pneumoniae infection. Types of systemic carbapenem-resistant Klebsiella pneumoniae infections included bacteremia (n = 15, 62.5%), ventilator-associated pneumonia (n = 4, 16.6%), ventriculitis (n = 2, 8.3%), intraabdominal infections (n = 2, 8.3%), and urinary tract infection (n = 1, 4.1%). A logistic regression model including parameters found significant in univariate analysis of carbapenem resistant Klebsiella pneumoniae colonization and carbapenem resistant Klebsiella pneumoniae infection groups revealed underlying metabolic disease (OR: 10.1; 95% CI: 2.7–37.2), previous carbapenem use (OR: 10.1; 95% CI: 2.2–40.1), neutropenia (OR: 13.8; 95% CI: 3.1–61.0) and previous surgical procedure (OR: 7.4; 95% CI: 1.9–28.5) as independent risk factors for carbapenem-resistant Klebsiella pneumoniae infection in patients colonized with carbapenem-resistant Klebsiella pneumoniae. Out of 24 patients with carbapenem resistant Klebsiella pneumoniae infection, 4 (16.6%) died of carbapenem-resistant Klebsiella pneumoniae sepsis. Conclusion Asymptomatic colonization with carbapenem-resistant Klebsiella pneumoniae in intensive care units of pediatric departments should alert health care providers about forthcoming carbapenem-resistant Klebsiella pneumoniae infection. Those carbapenem-resistant Klebsiella pneumoniae colonized patients at risk of developing infection due to carbapenem-resistant Klebsiella pneumoniae may be targeted for interventions to reduce subsequent infection occurence and also for timely initiation of empirical carbapenem-resistant Klebsiella pneumoniae active treatment, when necessary.
Descritores: Infecções por Klebsiella/microbiologia
Carbapenêmicos/farmacologia
Infecção Hospitalar/microbiologia
Farmacorresistência Bacteriana
Klebsiella pneumoniae/efeitos dos fármacos
Antibacterianos/farmacologia
-Reto/microbiologia
Infecções por Klebsiella/epidemiologia
Unidades de Terapia Intensiva Neonatal
Infecção Hospitalar/epidemiologia
Métodos Epidemiológicos
Progressão da Doença
Resistência beta-Lactâmica
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Klebsiella pneumoniae/isolamento & purificação
Limites: Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Id: lil-789481
Autor: Pereira, Jussyêgles Niedja da Paz; Rabelo, Marcelle Aquino; Lima, Jailton Lobo da Costa; Neto, Armando Monteiro Bezerra; Lopes, Ana Catarina de Souza; Maciel, Maria Amélia Vieira.
Título: Phenotypic and molecular characterization of resistance to macrolides, lincosamides and type B streptogramin of clinical isolates of Staphylococcus spp. of a university hospital in Recife, Pernambuco, Brazil
Fonte: Braz. j. infect. dis;20(3):276-281, May.-June 2016. tab, graf.
Idioma: en.
Resumo: Abstract Introduction There is a mechanism of macrolide resistance in Staphylococcus spp. which also affects the lincosamides and type B streptogramins characterizing the so-called MLSB resistance, whose expression can be constitutive (cMLSB) or inducible (iMLSB) and is encoded mainly by ermA and ermC genes. The cMLSB resistance is easily detected by susceptibility testing used in the laboratory routine, but iMLSB resistance is not. Therapy with clindamycin in cases of infection with isolated iMLSB resistance may fail. Objective To characterize the phenotypic (occurrence of cMLSB and iMLSB phenotypes) and molecular (occurrence of ermA and ermC genes) profiles of MLSB resistance of clinical isolates of susceptible and methicillin-resistant Staphylococcus aureus and CNS (coagulase-negative Staphylococcus) from patients of a university hospital, in Pernambuco. Methods The antimicrobial susceptibility of 103 isolates was determined by the disk diffusion technique in Mueller–Hinton agar followed by oxacillin screening. The iMLSB phenotype was detected by D test. Isolates with cMLSB and iMLSB phenotypes were subjected to polymerase chain reaction (PCR) for the detection of ermA and ermC genes. Results The cMLSB and iMLSB phenotypes were respectively identified in 39 (37.9%) and five (4.9%) isolates. The iMLSB phenotype was found only in four (10.8%) methicillin-susceptible S. aureus and one (4.5%) methicillin-resistant S. aureus. In the 44 isolates subjected to PCR, four (9.1%) only ermA gene was detected, a lower frequency when compared to only ermC 17 (38.6%) gene and to one (2.3%) isolate presenting both genes. Conclusion In the Staphylococcus spp. analyzed, the ermC gene was found more often than the ermA, although the iMLSB phenotype had been less frequent than the cMLSB. It was important to perform the D test for its detection to guide therapeutic approaches.
Descritores: Staphylococcus/efeitos dos fármacos
Staphylococcus/genética
Macrolídeos/farmacologia
Estreptogramina B/farmacologia
Farmacorresistência Bacteriana Múltipla/genética
Lincosamidas/farmacologia
-Fenótipo
Brasil
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Genes Bacterianos/genética
Hospitais Universitários
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-828149
Autor: Fraga, Edmir Geraldo; Nicodemo, Antonio Carlos; Sampaio, Jorge Luiz Mello.
Título: Antimicrobial susceptibility of Brazilian Clostridium difficile strains determined by agar dilution and disk diffusion
Fonte: Braz. j. infect. dis;20(5):476-481, Sept.-Oct. 2016. tab, graf.
Idioma: en.
Resumo: Abstract Clostridium difficile is a leading cause of diarrhea in hospitalized patients worldwide. While metronidazole and vancomycin are the most prescribed antibiotics for the treatment of this infection, teicoplanin, tigecycline and nitazoxanide are alternatives drugs. Knowledge on the antibiotic susceptibility profiles is a basic step to differentiate recurrence from treatment failure due to antimicrobial resistance. Because C. difficile antimicrobial susceptibility is largely unknown in Brazil, we aimed to determine the profile of C. difficile strains cultivated from stool samples of inpatients with diarrhea and a positive toxin A/B test using both agar dilution and disk diffusion methods. All 50 strains tested were sensitive to metronidazole according to CLSI and EUCAST breakpoints with an MIC90 value of 2 μg/mL. Nitazoxanide and tigecycline were highly active in vitro against these strains with an MIC90 value of 0.125 μg/mL for both antimicrobials. The MIC90 were 4 μg/mL and 2 μg/mL for vancomycin and teicoplanin, respectively. A resistance rate of 8% was observed for moxifloxacin. Disk diffusion can be used as an alternative to screen for moxifloxacin resistance, nitazoxanide, tigecycline and metronidazole susceptibility, but it cannot be used for testing glycopeptides. Our results suggest that C. difficile strains from São Paulo city, Brazil, are susceptible to metronidazole and have low MIC90 values for most of the current therapeutic options available in Brazil.
Descritores: Antibacterianos/farmacologia
-Valores de Referência
Tiazóis/farmacologia
Brasil
Ensaio de Imunoadsorção Enzimática
Vancomicina/farmacologia
Contagem de Colônia Microbiana/métodos
Reprodutibilidade dos Testes
Infecções por Clostridium/microbiologia
Teicoplanina/farmacologia
Fluoroquinolonas/farmacologia
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão/métodos
Carga Bacteriana
Moxifloxacina
Tigeciclina
Metronidazol/farmacologia
Minociclina/análogos & derivados
Minociclina/farmacologia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


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Id: biblio-1039190
Autor: Chamon, Raiane Cardoso; Ribeiro, Sthefanie da Silva; Costa, Thaina Miranda da; Nouér, Simone Aranha; Santos, Katia Regina Netto dos.
Título: Complete substitution of the Brazilian endemic clone by other methicillin-resistant Staphylococcus aureus lineages in two public hospitals in Rio de Janeiro, Brazil
Fonte: Braz. j. infect. dis;21(2):185-189, Mar.-Apr. 2017. tab.
Idioma: en.
Resumo: Abstract Staphylococcus aureus is an important cause of bloodstream infections. Therefore, the main purpose of this work was to characterize a collection of 139 S. aureus isolates from bloodstream infections in two public hospitals in relation to their antimicrobial susceptibility profile, staphylococcal cassette chromosome mec types, and clonal relationship. Methicillin resistance and resistance to other 12 agents were accessed by the disk diffusion test. Minimum inhibitory concentration to mupirocin was also determined. The SCCmec types were accessed by multiplex PCR, and the clonal relationship was determined by pulsed field gel electrophoresis method and restriction modification system characterization. Besides, multilocus sequence typing was performed for representative methicillin-resistant S. aureus isolates. The military hospital showed a dissemination of the New York/Japan (USA100/ST5/CC5/SCCmecII) lineage associated to multidrug resistance, including mupirocin resistance, and the teaching hospital presented polyclonal and non-multidrug resistant MRSA isolates. Complete substitution of the Brazilian endemic clone by other lineages was found in both hospitals. These findings can highlight differences in policy control and prevention of infections used in the hospitals and a change in the epidemiological profile of MRSA in Brazilian hospitals, with the replacement of BEC, a previously well-established clone, by other lineages.
Descritores: Infecções Estafilocócicas/microbiologia
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Antibacterianos/farmacologia
-Brasil
DNA Bacteriano/genética
Técnicas de Tipagem Bacteriana
Mupirocina/farmacologia
Eletroforese em Gel de Campo Pulsado
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Staphylococcus aureus Resistente à Meticilina/genética
Tipagem de Sequências Multilocus
Genótipo
Hospitais Públicos
Limites: Humanos
Tipo de Publ: Estudo Multicêntrico
Responsável: BR1.1 - BIREME


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Id: biblio-888893
Autor: Chaudhary, Manu; Mir, Mohd Amin; Ayub, Shiekh Gazalla.
Título: Safety and efficacy of a novel drug elores (ceftriaxone + sulbactam + disodium edetate) in the management of multi-drug resistant bacterial infections in tertiary care centers: a post-marketing surveillance study
Fonte: Braz. j. infect. dis;21(4):408-417, July-Aug. 2017. tab.
Idioma: en.
Resumo: Abstract Objective: In India, Elores (CSE-1034: ceftriaxone + sulbactam + disodium edetate) was approved as a broad spectrum antibiotic in year 2011 and is used for management of Extended Spectrum Beta Lactamases/Metallo Beta lactamases infections in tertiary care centers. The objective of this study was to investigate the efficacy of this drug in patients with Extended Spectrum Beta Lactamases/Metallo Beta lactamases infections and identify the incidence of adverse events in real clinical settings. Methods: This Post Marketing Surveillance study was conducted at 17 centers across India and included 2500 patients of all age groups suffering from various bacterial infections and treated with Elores (CSE1034). Information regarding demographic, clinical and microbiological parameters, dosage and treatment duration, efficacy and adverse events (AEs) associated with the treatment were recorded. Results: A total of 2500 patients were included in the study and efficacy was evaluated in 2487 patients. In total, 409 AEs were reported in 211 (8.4%) patients. The major AEs reported were vomiting (3.0%), pain at injection site (2.5%), nausea (2.3%), redness at site (1.96%), thrombophlebitis (1.4%). Of total reported AEs, 40 (5.3%) AEs were reported in pediatric, 310 (20.6%) in adult, and 59 (23.6%) in geriatric group. No AE belonging to grade IV or V was reported in any patient. In terms of efficacy, 1977 (79.4%) patients were cured, 501 (20.1%) patients showed clinical improvement and 5 (0.2%) patients were complete failure. The treatment duration varied from 5 to 7 days in different patients depending on the infection type. Conclusion: In this post-marketing surveillance study, CSE-1034 was found to be an effective and safe option against Pip tazo and meropenem in management of patients with multi-drug resistant (MDR) bacterial infections under routine ward settings.
Descritores: Infecções por Bactérias Gram-Positivas/microbiologia
Infecções por Bactérias Gram-Negativas/microbiologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
-Ceftriaxona/administração & dosagem
Ceftriaxona/efeitos adversos
Sulbactam/administração & dosagem
Sulbactam/efeitos adversos
Infecções por Bactérias Gram-Positivas/tratamento farmacológico
Infecções por Bactérias Gram-Negativas/tratamento farmacológico
Ácido Edético/administração & dosagem
Ácido Edético/efeitos adversos
Farmacorresistência Bacteriana
Combinação de Medicamentos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Bactérias Gram-Negativas/classificação
Bactérias Gram-Positivas/classificação
Índia
Antibacterianos/administração & dosagem
Antibacterianos/efeitos adversos
Antibacterianos/química
Limites: Humanos
Criança
Adulto
Idoso
Responsável: BR1.1 - BIREME


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Timenetsky, Jorge
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Id: biblio-1039197
Autor: Carvalho, Suzi P de; Almeida, Jéssica B de; Andrade, Yasmin M F S; Silva, Lucas S C da; Oliveira, Arianne C de; Nascimento, Flávia S; Campos, Guilherme B; Oliveira, Márcio V; Timenetsky, Jorge; Marques, Lucas M.
Título: Community-acquired methicillin-resistant Staphylococcus aureus carrying SCCmec type IV and V isolated from healthy children attending public daycares in northeastern Brazil
Fonte: Braz. j. infect. dis;21(4):464-467, July-Aug. 2017. tab.
Idioma: en.
Resumo: Abstract Nasal colonization with methicillin-resistant Staphylococcus aureus (MRSA) have increasingly been reported in healthy communities. This study aimed to assess the rate of S. aureus in general and MRSA in particular from nasal secretion of children in daycare centers in Vitória da Conquista, Brazil. The isolates were identified based on morphology, biochemical tests and by PCR. Detection of virulence genes, biofilm production, and susceptibility test by disk diffusion agar were performed. MRSA isolates were characterized by spa, SCCmec, and multilocus sequence typing (MLST). S. aureus were recovered from 70 (47.3%) of 148 children. Among the 11 MRSA strains (15.7%), two SCCmec types (IV and V) were detected. MLST identified four STs related to three clonal complexes (CC): 5, 45, and 398. Four spa types were found circulating in this setting. Resistance of S. aureus isolates to ampicillin, erythromycin, ciprofloxacin, clindamycin, and tetracycline was 80%, 32.8%, 7.1%, 7.1% and 4.3%, respectively. One isolate presented intermediate resistance to vancomycin detected by Etest methodology. All strains were biofilm producers. The virulence genes seb, sec, spa, and pvl were detected in some isolates. This study revealed a high rate of children carrying MRSA among healthy attendees in daycare centers in Vitória da Conquista, Brazil.
Descritores: Infecções Estafilocócicas/microbiologia
Creches
Nariz/microbiologia
-Infecções Comunitárias Adquiridas/microbiologia
Biofilmes/crescimento & desenvolvimento
Fatores de Virulência
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Staphylococcus aureus Resistente à Meticilina/isolamento & purificação
Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos
Staphylococcus aureus Resistente à Meticilina/patogenicidade
Genótipo
Antibacterianos/farmacologia
Limites: Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Responsável: BR1.1 - BIREME


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Id: biblio-1039226
Autor: Gutiérrez, Camila; Zenis, Javier; Legarraga, Paulette; Cabrera-Pardo, Jaime R; García, Patricia; Bello-Toledo, Helia; Opazo-Capurro, Andrés; González-Rocha, Gerardo.
Título: Genetic analysis of the first mcr-1 positive Escherichia coli isolate collected from an outpatient in Chile
Fonte: Braz. j. infect. dis;23(3):203-206, May-June 2019. graf.
Idioma: en.
Projeto: Fondecyt.
Resumo: ABSTRACT Global dissemination of mcr-like genes represents a serious threat to public health since it jeopardizes the effectiveness of colistin, an antibiotic used as a last-resort treatment against highly antibiotic-resistant bacteria. In 2017, a mcr-1-positive isolate of Escherichia coli was found in Chile for the first time. Herein we report the genetic features of this strain (UCO-457) by whole-genome sequencing (WGS) and conjugation experiments. The UCO-457 strain belonged to ST4204 and carried a 285 kb IncI2-type plasmid containing the mcr-1 gene. Moreover, this plasmid was transferred by conjugation to an E. coli J53 strain at high frequency. The isolate harbored the cma, iroN, and iss virulence genes and did carry resistance genes to trimethoprim/sulfamethoxazole and fluoroquinolones. Other antibiotic resistance determinants such as β-lactamases-encoding genes were not detected, making the isolate highly susceptible to these antibiotics. Our results revealed that such susceptible isolates could be acting as platforms to disseminate plasmid-mediated colistin resistance. Based on this evidence, we consider that mcr-like prevalence deserves urgent attention and should be examined not only in highly resistant bacteria but also in susceptible isolates.
Descritores: Proteínas de Escherichia coli/genética
Escherichia coli/genética
Infecções por Escherichia coli/microbiologia
-Pacientes Ambulatoriais
Chile
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Antibacterianos/farmacologia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Lage, Andrey Pereira
Lobato, Zélia Inês Portela
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Id: biblio-1122160
Autor: Serpa, Maysa; Nascimento, Juliana Amália Fonte Bôa do; Alves, Mirian Fátima; Guedes, Maria Isabel Maldonado Coelho; Reis, Adrienny Trindade; Heinemann, Marcos Bryan; Lage, Andrey Pereira; Lobato, Zélia Inês Portela; Dorneles, Elaine Maria Seles.
Título: Antimicrobial resistance in bacteria isolated from pigs with respiratory clinical signs in Brazil / Resistência a antimicrobianos em bactérias isoladas de suínos com sinais clínicos respiratórios no Brasil
Fonte: Braz. J. Vet. Res. Anim. Sci. (Online);57(1):e160956, 2020. ilus, mapas, tab.
Idioma: en.
Projeto: Coordination for the Improvement of Higher Education Personnel (CAPES).
Resumo: Antimicrobial resistance is a current and important issue to public health, and it is usually associated with the indiscriminate use of antimicrobials in animal production. This study aimed to evaluate the antimicrobial susceptibility profile in bacterial isolates from pigs with clinical respiratory signs in Brazil. One hundred sixty bacterial strains isolated from pigs from 51 pig farms in Brazil were studied. In vitro disk-diffusion method was employed using 14 antimicrobial agents: amoxicillin, penicillin, ceftiofur, ciprofloxacin, enrofloxacin, chlortetracycline, doxycycline, oxytetracycline, tetracycline, erythromycin, tilmicosin, florfenicol, lincomycin, and sulfadiazine/trimethoprim. The majority of isolates were resistant to at least one antimicrobial agent (98.75%; 158/160), while 31.25% (50/160) of the strains were multidrug resistant. Streptococcus suis and Bordetella bronchiseptica were the pathogens that showed higher resistance levels. Haemophilus parasuis showed high resistance levels to sulfadiazine/trimethoprim (9/18=50%). We observed that isolates from the midwestern and southern regions exhibited four times greater chance of being multidrug resistant than the isolates from the southeastern region studied. Overall, the results of the present study showed a great level of resistance to lincomycin, erythromycin, sulfadiazine/trimethoprim, and tetracycline among bacterial respiratory pathogens isolated from pigs in Brazil. The high levels of antimicrobial resistance in swine respiratory bacterial pathogens highlight the need for the proper use of antimicrobials in Brazilian pig farms.(AU)

A resistência antimicrobiana é uma questão atual e muito importante para a saúde pública, geralmente associada ao uso indiscriminado de antimicrobianos na produção animal. Diante disso, foi investigado o perfil de sensibilidade-antimicrobiana em isolados bacterianos de suínos com sinais clínicos respiratórios no Brasil. Foram estudadas 96 isolados provenientes de 51 granjas de suínos do Brasil. O método de disco-difusão foi empregado usando 14 antimicrobianos: amoxicilina, penicilina, ceftiofur, ciprofloxacina, enrofloxacina, clortetraciclina, doxiciclina, oxitetraciclina, tetraciclina, eritromicina, tilmicosina, florfenicol, lincomicina e sulfadiazina/trimetoprim. Streptococcus suis e Bordetella bronchiseptica foram os patógenos que apresentaram maiores níveis de resistência. Haemophilus parasuis apresentou altos níveis de resistência à sulfadiazina/trimetoprim (9/18=50%). Observou-se que isolados das regiões Centro-Oeste e Sul apresentaram quatro vezes mais chance de serem multirresistentes do que os isolados da região Sudeste. A maioria foi resistente a pelo menos um agente antimicrobiano (98,75%; 158/160) e 31,25% (50/160) das estirpes isoladas eram multirresistentes. No geral, os resultados do presente estudo mostraram grande nível de resistência à lincomicina, eritromicina, sulfadiazina/trimetoprim e tetraciclina entre patógenos respiratórios bacterianos isolados de suínos no Brasil. Os altos níveis de resistência antimicrobiana em patógenos bacterianos respiratórios em suínos reforçam a necessidade do uso criterioso de antimicrobianos na suinocultura brasileira.(AU)
Descritores: Suínos
Bordetella bronchiseptica
Farmacorresistência Bacteriana Múltipla
-Streptococcus
Brasil/epidemiologia
Pasteurella multocida
Actinobacillus pleuropneumoniae
Haemophilus parasuis
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão/veterinária
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-619654
Autor: Martins, Renata Gusson Angelune.
Título: Avaliação do perfil de sensibilidade a antimicrobianos de Stenotrophomonas maltophilia, Complexo Burkholderia cepacia, Burkholderia gladioli e Achromobacter xylosoxidans subsp. xylosoxidans obtidos de amostras respiratórias de pacientes portadores de fibrose cística / Evaluation of antibiotic susceptibility of Stenotrophomonas maltophilia, Burkholderia cepacia complex, Burkholderia gladioli and Achromobacter xylosoxidans subsp. xylosoxidans recovered from respiratory samples from cystic fibrosis patients.
Fonte: São Paulo; s.n; 2011. [178] p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a São Paulo(Estado) Secretaria da Saúde. Coordenadoria de Controle de Doenças. Programa de Pós Graduação em Ciências para obtenção do grau de Mestre.
Resumo: Fibrose Cística (FC) é uma doença autossômica recessiva causada por mutações no canal de cloreto CFTR e caracterizada por uma extensa gama de sinais e sintomas clínicos. Devido a alterações na composição eletrolítica da camada de líquido periciliar, uma série de fatores converge para o estabelecimento de infecção e inflamação pulmonar crônicas. Stenotrophomonas matophilia (SM), Complexo Burkholderia cepacia (CBc), Burkholderia gladioli (Bg) e Achromobacter xylosoxidans subsp. xylosoxidans (Ax) são bacilos Gram-negativos não fermentadores frequentemente isolados de culturas de amostras respiratórias de pacientes com FC e intrinsecamente resistentes a diversas classes de antimicrobianos. O presente estudo buscou avaliar o perfil de sensibilidade destes microrganismos isolados de amostras respiratórias de pacientes fibrocísticos atendidos no Instituto da Criança do HC-FMUSP. Um total de 781 amostras foi obtido entre junho de 2003 a junho de 2004 e setembro de 2006 a setembro de 2007. Deste total, foram isoladas 57 cepas (7,3%) de SM (23 no primeiro e 34 no segundo períodos), 34 cepas (4,4%) de CBc (22 no primeiro e 12 no segundo períodos), 8 cepas (1%) de Bg (5 no primeiro e 3 no segundo períodos) e 23 ( 2,9%) de Ax (17 no primeiro e 6 no segundo períodos). Os isolados foram submetidos ao teste de disco-difusão (DD) frente a 22 anitimicrobianos. A verificação da Concentração Inibitória Mínima (CIM) foi realizada pelo método da diluição em ágar e teste epsilométrico. Pesquisou-se, fenotipicamente, a produção de beta-lactamases do tipo Beta-Lactamase de Espectro Estendido (ESBL) e Metalo-Beta-Lactamase (MBL). Minociclina foi a droga mais ativa, inibindo 100% das cepas estudadas. Sulfametoxazol-trimetoprim ainda apresenta um bom desempenho contra SM, porém, verificou-se resistência de 10,5%. Levofloxacina inibiu 96% das cepas de SM. Piperacilina-tazobactam foi ativa contra 100% das cepas do gênero Burkholderia e Ax. Notou-se diferenças importantes entre...
Descritores: Achromobacter denitrificans
Burkholderia gladioli
Fibrose Cística
Stenotrophomonas maltophilia
Testes de Sensibilidade Microbiana
-Eletroforese em Gel de Ágar
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Limites: Humanos
Masculino
Feminino
Responsável: BR91.2 - Centro de Documentação
BR91.2; W4, M386av, 2011



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