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Id: biblio-886195
Autor: Duzgun, Ozgul; Sarici, Inanc Samil; Gokcay, Serkan; Ates, Kivilcim Eren; Yılmaz, Mehmet Bertan.
Título: Effects of nivolumab in peritoneal carcinamatosis of malign melanoma in mouse model
Fonte: Acta cir. bras;32(12):1006-1012, Dec. 2017. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To evaluate the efficacy of nivolumab and comparison with dacarbazine (DTIC) on peritoneal carcinomatosis of malignant melanoma in mouse model. Methods: Mouse skin melanoma cells was injected under the capsule of the peritoneal surface in the left side of the abdomen. On postoperative day ten, mouses randomised into three groups. Group 1: Control, Group 2: HIPEC (Hyperthermic intraperitoneal chemotherapy) with DTIC and Group 3: HIPEC with Nivolumab. After the sacrification on postoperative day fifteen, peritoneum evaluated macroscopically and histopathologically by using peritoneal regression grading score (PRGS). Results: In the 15th day exploration, all animals developed extensive intraperitoneal tumor growth in Group 1. In Group 2 and Group 3 median tumor size was 0.7±0.3cm and 0.3±0.2cm respectively (p: 0.023). Peritoneal carcinomatosis index (PCI) were significantly lower in Group 3 than other groups (p: 0.019). The lowest total tumor nodules in group 3 was 4 ± 2. The PGRS score was found significantly lower in Group 3 than other groups (p: 0.03). Lymphocytic response rate was found higher in the Group 3. Conclusions: It has been found that nivolumab significantly better than DTIC on peritoneal metastases of malign melanoma in mouse models. Nivolumab treatment gives promising results with pathological evidence in the treatment of metastatic disease of malignant melanoma.
Descritores: Neoplasias Peritoneais/tratamento farmacológico
Peritônio/patologia
Melanoma/tratamento farmacológico
Anticorpos Monoclonais/farmacologia
Antineoplásicos/farmacologia
-Neoplasias Peritoneais/cirurgia
Neoplasias Peritoneais/patologia
Neoplasias Peritoneais/secundário
Peritônio/efeitos dos fármacos
Distribuição Aleatória
Análise de Regressão
Dacarbazina/uso terapêutico
Modelos Animais de Doenças
Avaliação Pré-Clínica de Medicamentos
Gradação de Tumores
Nivolumabe
Hipertermia Induzida
Melanoma/secundário
Anticorpos Monoclonais/uso terapêutico
Antineoplásicos/uso terapêutico
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Costa, Waldemar Silva
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Id: biblio-1054671
Autor: Osorio, Clarice Fraga Esteves Maciel; Costa, Waldemar Silva; Gallo, Carla Braga Mano; Sampaio, Francisco José Barcellos.
Título: Expression of stromal elements of prostatic adenocarcinoma in different gleason scores
Fonte: Acta cir. bras;34(10):e201901005, Oct. 2019. tab, graf.
Idioma: en.
Resumo: Abstract Purpose: To quantify and compare the expression of stromal elements in prostate adenocarcinoma of different Gleason scores with non-tumor area (control). Methods: We obtained 132 specimens from samples of prostate peripheral and transition zone. We analyzed the following elements of the extracellular matrix: collagen fibers, elastic system, smooth muscle fibers and blood vessels. The tumor area and non-tumor area (control) of the TMA (tissue microarray) were photographed and analyzed using the ImageJ software. Results: The comparison between the tumor area and the non-tumor area showed significant differences between stromal prostate elements. There was an increase of collagen fibers in the tumor area, mainly in Gleason 7. Elastic system fibers showed similar result, also from the Gleason 7. Blood vessels showed a significant increase occurred in all analyzed groups. The muscle fibers exhibited a different behavior, with a decrease in relation to the tumor area. Conclusions: There is a significant difference between the extracellular matrix in prostate cancer compared to the non-tumor area (control) especially in Gleason 7. Important modifications of the prostatic stromal elements strongly correlate with different Gleason scores and can contribute to predict the pathological staging of prostate cancer.
Descritores: Neoplasias da Próstata/patologia
Adenocarcinoma/patologia
Células Estromais/patologia
-Valores de Referência
Vasos Sanguíneos/patologia
Estudos Retrospectivos
Colágeno/análise
Análise Serial de Tecidos
Tecido Elástico/anatomia & histologia
Gradação de Tumores
Músculo Liso/patologia
Limites: Humanos
Masculino
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-1022835
Autor: Rojas, Pablo; Viviani, Paola; Montecinos, Viviana; Zhou, Yu Ting; Morales, Claudio; Godoy, Alejandro; Francisco, Ignacio San.
Título: Score genético predice agresividad del cáncer de próstata / Genetic score predicts aggressiveness of prostate cancer
Fonte: ARS med. (Santiago, En línea);43(2):17-24, 2018. Tab.
Idioma: es.
Resumo: Establecer un score genético utilizando los polimorfismos de nucleótido único (SNPs) del gen que codifica para Ribonucleasa L (RNASEL)y regiones cromosómicas 8q24 y 17q12-24 en combinación con el antígeno específico de la próstata (PSA) para predecir la agresividad del cáncer de próstata (CaP). Pacientes y métodos: hombres con CaP tratados con prostatectomía radical. Se analizaron variables clínicas y patológicas: edad al diagnóstico, PSA al diagnóstico, el volumen tumoral (TV) y extensión extracapsular (ECE) según el TNM (tumour, node and metastasis) (ECE ≥T3) y score de Gleason. Desarrollamos un modelo de puntaje genético usando regresión logística multivariable. Resultados: se incluyeron 86 pacientes sometidos a prostatectomía radical. Edad promedio fue de 62 ± 7,5 años. El promedio de PSA fue de 11,3 ± 10,6 ng/mL. Treinta y un pacientes (36 por ciento) tuvieron ECE. La mediana del TV fue de 3,8 cc. Un PSA ≥ 10 ng/mL se asoció con una mayor tasa de ECE (p <0,05) y TV más alto (p = 0,032). En el análisis univariable, los pacientes con > 1 SNP tienen mayor riesgo de ECE que los pacientes con ≤ 1 SNP (42 por ciento vs. 10,5 por ciento, p = 0,01), y los pacientes con ≥ 3 SNP tienen más TV que los pacientes con <3 SNP (60 por ciento vs. 32 por ciento, p = 0,015). Se crearon dos modelos de riesgo usando el número de SNP y PSA ≥ o <10 ng/mL para predecir ECE (sensibilidad 67 por ciento y especificidad 84 por ciento) y TV (sensibilidad 59 por ciento y especificidad 70 por ciento). Conclusiones: El score genético presentado en este estudio es una herramienta novedosa para predecir indicadores de agresividad del CaP, como ECE y TV.(AU)

To establish a genetic score using SNPs (from RNAsel and chromosomal regions 8q24 and 17q12-24) in combination with Prostate Specific Antigen (PSA) at diagnosis to predict aggressiveness of PCa (tumor volume (TV) and extracapsular extension (ECE)). Patients and methods: Men with PCa diagnosed by needle biopsy and treated with radical prostatectomy (RP). Clinical and pathological variables such as age at diagnosis, PSA at diagnosis, TV, extension of tumor according TNM (ECE ≥T3) and Gleason score where analyzed. We developed a genetic score model using Multivariate Logistic Regression. Results: We included 86 patients who underwent RP. Mean age 62 ± 7.5 years. Mean PSA was 11.3 ± 10.6 ng/mL. Thirty-one patients (36 percent) had ECE. Median TV was 3.8 cc. PSA ≥ 10 ng/mL was associated with increased rate of ECE (p <0.05) and higher TV (p = 0.032). In univariate analysis, patients with more than 1 SNP had a greater risk of ECE than patients with ≤ 1 SNP (42 percent vs. 10.5 percent, p = 0.01), and patients with ≥ 3 risk SNPs had more TV than patients with <3 SNPs risk (60 percent vs. 32 percent, p = 0.015). Two models of risk using the number of SNPs and PSA ≥ or <10 ng/mL to predict ECE (sensitivity 67 percent and specificity 84 percent) and TV (sensitivity 59 percent and specificity 70 percent) were created. Conclusions: Genetic score usingdescribed SNPs and preoperative PSA can predict aggressiveness of PCa, which would be useful to define a management with more information at diagnosis especially in localized cancers.(AU)
Descritores: Neoplasias da Próstata
Gradação de Tumores
-Antígeno Prostático Específico
Polimorfismo de Nucleotídeo Único
Limites: Humanos
Masculino
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Artigo Clássico
Responsável: CL10.1 - Biblioteca Biomédica


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Id: biblio-890736
Autor: Plzák, Jan; Kratochvil, Vít; Kešner, Adam; Šurda, Pavol; Vlasák, Aleš; Zvěřina, Eduard.
Título: Endoscopic endonasal approach for mass resection of the pterygopalatine fossa
Fonte: Clinics;72(9):554-561, Sept. 2017. tab, graf.
Idioma: en.
Projeto: Ministry of Health of the Czech Republic.
Resumo: OBJECTIVES: Access to the pterygopalatine fossa is very difficult due to its complex anatomy. Therefore, an open approach is traditionally used, but morbidity is unavoidable. To overcome this problem, an endoscopic endonasal approach was developed as a minimally invasive procedure. The surgical aim of the present study was to evaluate the utility of the endoscopic endonasal approach for the management of both benign and malignant tumors of the pterygopalatine fossa. METHOD: We report our experience with the endoscopic endonasal approach for the management of both benign and malignant tumors and summarize recent recommendations. A total of 13 patients underwent surgery via the endoscopic endonasal approach for pterygopalatine fossa masses from 2014 to 2016. This case group consisted of 12 benign tumors (10 juvenile nasopharyngeal angiofibromas and two schwannomas) and one malignant tumor. RESULTS: No recurrent tumor developed during the follow-up period. One residual tumor (juvenile nasopharyngeal angiofibroma) that remained in the cavernous sinus was stable. There were no significant complications. Typical sequelae included hypesthesia of the maxillary nerve, trismus, and dry eye syndrome. CONCLUSION: The low frequency of complications together with the high efficacy of resection support the use of the endoscopic endonasal approach as a feasible, safe, and beneficial technique for the management of masses in the pterygopalatine fossa.
Descritores: Neoplasias Nasofaríngeas/cirurgia
Angiofibroma/cirurgia
Fossa Pterigopalatina/cirurgia
Cirurgia Endoscópica Transanal/métodos
Neurilemoma/cirurgia
-Imagem por Ressonância Magnética/métodos
Carcinoma/cirurgia
Carcinoma/patologia
Carcinoma/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
Neoplasias Nasofaríngeas/patologia
Neoplasias Nasofaríngeas/diagnóstico por imagem
Neoplasias Nasais/cirurgia
Neoplasias Nasais/patologia
Neoplasias Nasais/diagnóstico por imagem
Reprodutibilidade dos Testes
Estudos Retrospectivos
Seguimentos
Resultado do Tratamento
Angiofibroma/patologia
Angiofibroma/diagnóstico por imagem
Embolização Terapêutica/métodos
Fossa Pterigopalatina/patologia
Fossa Pterigopalatina/diagnóstico por imagem
Gradação de Tumores
Neurilemoma/patologia
Neurilemoma/diagnóstico por imagem
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-889036
Autor: Zhang, X; Song, Y; Song, N; Zhang, L; Wang, Y; Li, D; Wang, Z; Qu, X; Liu, Y.
Título: Rankl expression predicts poor prognosis in gastric cancer patients: results from a retrospective and single-center analysis
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(3):e6265, 2018. tab, graf.
Idioma: en.
Projeto: National Science and Technology Major Project; . Science and Technology Plan Project; . Chinese National Foundation of National Sciences; . Liaoning BaiQianWan Talents Program.
Resumo: The receptor activator of nuclear factor κB ligand (RANKL)/RANK pathway plays an important role in the prognosis of several solid tumor types, but its role in gastric cancer prognosis has been poorly characterized. A total of 116 gastric cancer patients who underwent surgical resection were enrolled in this study. Expressions of RANKL and RANK in gastric cancer tissues were detected using immunohistochemical staining. Thirty-eight patients (33%) showed a high level of RANKL expression and 61 patients (53%) showed a high level of RANK expression. There was a positive correlation between expressions of RANKL and RANK (P=0.014, r=0.221). A high level of RANKL expression indicated shorter overall survival (OS) (P=0.008), and was associated with a higher pathological tumor/lymph node/metastasis (pTNM) stage (P=0.035), while no significant correlation was detected between RANK expression and clinicopathological parameters. RANKL also predicted poor prognosis in patients with high RANK expression (P=0.008) and Bormann's type III/IV (P=0.002). Furthermore, RANKL expression correlated with pTNM stage according to high RANK expression (P=0.009), while no significance was found in patients with low RANK expression (P=1.000). Together, our results revealed that high expression of RANKL could predict worse outcomes in gastric cancer especially combined with RANK detection, and thereby this pathway could be a useful prognostic indicator of gastric cancer.
Descritores: Neoplasias Gástricas/metabolismo
Adenocarcinoma/metabolismo
Ligante RANK/metabolismo
Proteínas de Neoplasias/metabolismo
-Prognóstico
Neoplasias Gástricas/cirurgia
Neoplasias Gástricas/mortalidade
Neoplasias Gástricas/patologia
Imuno-Histoquímica
Adenocarcinoma/cirurgia
Adenocarcinoma/mortalidade
Adenocarcinoma/patologia
Regulação Neoplásica da Expressão Gênica
China/epidemiologia
Estudos Retrospectivos
Estatísticas não Paramétricas
Gradação de Tumores
Estadiamento de Neoplasias
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-841446
Autor: Bolaños Morera, Pamela; Chacón Araya, Carolina.
Título: Escala patológica de Gleason para el cáncer de próstata y sus modificaciones / Pathological scale of Gleason for prostate cancer and its modifications
Fonte: Med. leg. Costa Rica;34(1):237-243, ene.-mar. 2017. tab, ilus.
Idioma: es.
Resumo: Resumen:El sistema de puntuación o escala de Gleason es una herramienta ampliamente utilizada en la actualidad debido a su adecuada orientación pronóstica y de tratamiento en la evaluación del adenocarcinoma prostático. Dicha escala ha sufrido diversas modificaciones desde sus inicios en los años sesenta así como en los últimos años, las cuales buscan facilitar y homogenizar los criterios patológicos de cada una de sus categorías.

Summary:The Gleason scoring system is a tool widely used today due to its adequate prognostic and treatment orientation in the evaluation of prostatic adenocarcinoma. This scale has suffered several modifications since its beginnings in the sixties as well as in recent years, which seek to facilitate and homogenize the pathological criteria of each of its categories.
Descritores: Neoplasias da Próstata/classificação
Gradação de Tumores/métodos
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Id: biblio-994785
Autor: Hashmi, Atif Ali; Hashmi, Shumaila Kanwal; Irfan, Muhammad; Asif, Huda; Nisar, Laila; Naeem, Maheen; Khan, Erum Yousuf; Baloch, Samina; Faridi, Naveen.
Título: Prognostic utility of epidermal growth factor receptor (EGFR) expression in prostatic acinar adenocarcinoma
Fonte: Appl. cancer res;39:1-8, 2019. ilus, tab.
Idioma: en.
Resumo: Background: Epidermal growth factor receptor (EGFR) is potential prognostic biomarker expressed in many human cancers. Prognostic significance of EGFR immunohistochemical expression has not been established in prostatic acinar adenocarcinoma, therefore we aimed to evaluate the frequency of expression of EGFR in prostatic adenocarcinoma and its association with other prognostic parameters. Methods: The study included 123 cases of biopsy proven prostatic acinar adenocarcinoma treated at Liaquat National hospital, Karachi from January 2013 till December 2017. Paraffin blocks of all cases were retrieved; sections were cut and stained with haematoxylin and eosin. Pathologic characteristics including tumor quantification, WHO grade group, gleason score, perineural and lymphovascular invasion were evaluated. EGFR immunohistochemistry (IHC) was performed on all tissue blocks. Results: Mean age of the patients included in the study was 69.05±8.68years. High gleason scores i.e. 8 & 9 were noted in 22% (27 cases) and 22.8% (28 cases) respectively. Similarly, 22.8% (28 cases) showed WHO grade group 5. 52.8% (65 cases) had > 50% tissue involvement by carcinoma and perineural invasion was seen in 37.4% (46 cases). Positive EGFR expression was noted in 18.7% (23 cases), while 81.3% (100 cases) showed negative EGFR expression. Significant association of EGFR expression was noted with gleason score (p-value = < 0.001), WHO grade (p = < 0.001), tumor quantification (p =0.007) and perineural invasion (p = < 0.001). Moreover, significant association of EGFR expression was also seen with disease recurrence and Her2neu over expression. Patients with low gleason scores (score 6 and 7) and lower grade group (1, 2 & 3) were less likely to have positive EGFR expression as compared to patients with high gleason score (score 9) and higher grade group (5). Similarly, patients with perineural invasion were more likely to have positive EGFR expression. Conclusion: We found a relatively low EGFR expression in our patients with prostatic adenocarcinoma; however, its association with poor prognostic parameters like high gleason score, higher grade group, perineural invasion, higher tissue involvement by cancer and disease recurrence signifies its importance as a prognostic parameter in prostatic acinar adenocarcinoma (AU)
Descritores: Prognóstico
Neoplasias da Próstata/genética
Imuno-Histoquímica
Receptores ErbB
Carcinoma de Células Acinares
Genes erbB-1
Gradação de Tumores
Limites: Humanos
Masculino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR30.1 - Biblioteca


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Id: biblio-994774
Autor: Picanço-Albuquerque, C G; Vidotto, T; Pereira, C S; Saggioro, F P; Jamaspishvili, T; Berman, D M; Squire, J A; Reis, R B.
Título: PTEN loss in Gleason grade 7 prostate tumors exhibits intratumoral heterogeneity and is associated with unfavorable pathological features
Fonte: Appl. cancer res;39:1-6, 2019. ilus, tab.
Idioma: en.
Resumo: Background: PTEN loss is observed in 20­30% of prostate cancers and is associated with a poor outcome, but clinical details of the impact of this biomarker are unclear for intermediate grade tumors. Methods: We investigated 43 radical prostatectomy-derived grade 7 prostate tumors from the Clinics Hospital of Ribeirão Preto. Tissue microarray (TMA) blocks were constructed and PTEN copy number status was determined for all patients through fluorescence in situ hybridization (FISH). To determine the presence of PTEN protein loss in our study cohort, we performed immunohistochemistry (IHC) in TMA sections. We then developed an automated algorithm in HALO™ to identify regions of PTEN protein loss in whole prostate scanned sections from ten patients with known PTEN deletion status by FISH. Clinical analyses were conducted to determine the associations between PTEN loss and patient outcome. All statistical analyses were conducted in R v3.4.3 with P-values below 0.05 being considered statistically significant. Results: In this study of 43 grade 7 tumors, we found PTEN deletions by FISH in 18.9% of tumors, and PTEN protein loss by IHC in 16.3% of tumors. Both techniques were highly concordant and complementary. Clinical analysis demonstrated that PTEN deletion by FISH was significantly associated with positive margin invasion (P = 0.04) and Gleason score upgrade (P = 0.001). Digital image analysis of ten representative tumors demonstrated distinct intratumoral heterogeneity for PTEN protein loss in four tumors. Conclusions: This study shows that PTEN loss in Gleason grade 7 tumors can be heterogeneous and that a systematic analysis of this biomarker using a combination of FISH, IHC, and digital imaging may identify patients with a greater risk of poor outcome (AU)
Descritores: Prostatectomia
Neoplasias da Próstata/classificação
Imuno-Histoquímica
Hibridização in Situ Fluorescente
Heterogeneidade Genética
PTEN Fosfo-Hidrolase
Gradação de Tumores
Limites: Masculino
Feminino
Responsável: BR30.1 - Biblioteca


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Id: biblio-971942
Autor: Aquino, Ranniere Gurgel Furtado de.
Título: Perfil anatomopatológico dos carcinomas ductais em um serviço de referência de Fortaleza de2005 a 2014: correlação com a idade e com as metástases axilares.
Fonte: Fortaleza; s.n; 2016. 60 p. ilus, tab, graf.
Idioma: pt.
Tese: Apresentada a Universidade Federal do Ceará para obtenção do grau de Mestre.
Resumo: O câncer de mama é o que mais acomete mulheres no mundo; e suas características morfológicas, a despeito da atual classificação molecular, ainda fornecem informações importantes sobre comportamento desta doença. No intuito de padronizar a classificação morfológica do câncer de mama e de refinar a aplicabilidade clínica dos laudos anatomo patológicos, foi proposta a classificação do grau histológico de Scarff-Bloom-Richardson que, posteriormente, foi modificada pelo grupo de Nottingham, onde os tumores recebem graus 1, 2 e 3 de acordo com os achados estruturais e celulares. Em 1991, seu valor prognóstico foi demonstrado pela primeira veze, desde então, diversos estudos a validaram, o que a tornou um sistema de classificação recomendado mundialmente. O objetivo deste estudo foi conhecer o perfil anatomo patológico dos carcinomas ductais de pacientes tratadas na Maternidade Escola Assis Chateubriant, correlacionando com a faixa etária e com as metástases axilares.Foram estudados 302 casos de carcinoma ductal de pacientes do serviço de Mastologia da Universidade Federal do Ceará -UFC, no período de 2005 a 2014, tendo como ponto de corte a idade: ≤ 50 anos e acima de 50 anos. Foram analisadas as características morfológicas: maior diâmetro do tumor, presença de metástase axilar e grau histológico. Em seguida, foram determinados os graus histológico, tubular e nuclear e o índice mitótico na metástase axilar para comparação com os achados do tumor primário. A idade média das pacientes foi 55,6 anos. O tamanho médio dos tumores foi 3,4 cm. 40% dos tumores possuíam diâmetro ≤2cm e 60% > 2cm...

Breast cancer is the most common cancer in women world wide, and its morphological characteristics, despite the current molecular classification, also provide important information about the pattern of this disease. In order to standardize the morphological classification of breast cancer and to refine the clinical applicability of anatomo pathological reports, the histological grade of Scarff-Bloom-Richardson (SBR) system was proposed, which, later was modified by Nottingham group, in which tumors are graded 1, 2 and 3 according to the structural and cellular findings. In 1991, its prognostic value was demonstrated for the first timeand, since then, several studies have validated it, which has made it a classification system recommended world wide. The aim ofthis study was to understand the pathological profile of ductal carcinomas of the Maternidade Escola Assis Chateubriant, correlating with age and with axillary metastases. They studied 302 cases of ductal carcinoma patients from Mastology service of Universidade Federal do Ceará -UFC in the period 2005-2014, aged ≤ 50 years and above 50 years. The following morphological characteristics were analyzed: larger diameter of the tumor, axillary metastasis and histological grade. Itwas determinate histological grade, tubular grade, nuclear grade and mitotic index in axillary metastasis to compare with primary tumor. The average age of patients was 55.6 years. The average tumor size was 3.4 cm. 40 % of the tumors have diameter ≤ 2cm and 60% > 2cm...
Descritores: Neoplasias da Mama
Gradação de Tumores
Carcinoma Ductal de Mama
Distribuição por Idade
Limites: Humanos
Responsável: BR6.1 - BCS - Biblioteca de Ciências da Saúde
BR6.1


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Id: biblio-905717
Autor: Acuña, J; Marió, C; Anguita, C; Orellana, S; Vergara, C; Avillo, V; Badilla, S; Novoa, C; Leyton, R.
Título: Correlación del score de gleason en biopsia prostática con el de pieza operatoria. ¿Cuál es nuestro porcentaje de upgrading? / Correlation between Gleason Score of prostate biopsy and prostatectomy specimen. ¿How high is our upgrading rate?
Fonte: Rev. chil. urol;82(1):16-21, 2017. graf.
Idioma: es.
Resumo: Introducción. El cáncer de próstata es el segundo cáncer más prevalente del mundo y ocupa el quinto lugar en mortalidad en hombres. El score de Gleason es el factor pronósticos más importante. Sin embargo, numerosos estudios han reportado diferencias entre el score de Gleason de la biopsia prostática y el obtenido de la pieza operatoria. Es por este motivo que el objetivo del presente estudio, es evaluar la concordancia entre el score de Gleason de la biopsia prostática transrectal comparado con el de la pieza operatoria de la prostatectomia radical.(AU)

Introduction. Prostate cancer is the second most prevalent cancer in the world, and occupies the fifth place in mortality among men. Gleason score (GS) is the most important prognostic factor. However, a number of studies have reported differences between the GS of the trans rectal biopsy and the prostatectomy specimen. That is the reason of the this study, our objective is to evaluate concordance between Gleason scores, of the biopsy and the prostatectomy specimen.(AU)
Descritores: Gradação de Tumores
-Prostatectomia
Limites: Masculino
Tipo de Publ: Relatos de Casos
Responsável: CL10.1 - Biblioteca Biomédica



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