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Id: lil-584310
Autor: Fuentes Valdés, Edelberto; Corona Mancebo, Sixto; Martín González, Miguel.
Título: Cambio de estadio clínico en el cáncer pulmonar no microcítico / Clinical stage change in nonmicrocyst pulmonary cancer
Fonte: Rev. cuba. cir;49(3), jul.-sep. 2010.
Idioma: es.
Resumo: El cambio de estadio clínico del carcinoma pulmonar no microcítico al comparar los períodos pre y posoperatorio puede repercutir negativamente a la hora de definir las estrategias terapéuticas. El objetivo del presente estudio fue evaluar la magnitud de dichos cambios y su efecto sobre el paciente. Se realizó un estudio retrospectivo con una base de datos prospectiva de 259 pacientes tratados entre enero de 2002 y diciembre de 2007. Se excluyeron enfermos con tratamiento neoadyuvante, intervenciones por recidiva o paliativas y neoplasias de células pequeñas. Las variables estudiadas fueron los factores tumor (T), nódulos (N) y metástasis (M), posición y localización del tumor y pulmón afectado. El coeficiente de concordancia permitió evaluar la magnitud del cambio y la prueba de ji al cuadrado, la asociación entre dos variables. Valores de p < 0,05 se consideraron significativos. . El factor T cambió en 91 pacientes (35,1 por ciento), con más frecuencia en lesiones de lóbulos superiores (p = 0,04). La posición no se asoció al cambio (p = 0,110). El factor N se modificó en 50 casos (19,3 por ciento). Se asociaron al cambio: localización lobular (p = 0,001), pulmón afectado (p = 0,002) y factor T (p = 0,013). El cambio del factor M ocurrió en 11 pacientes (4,2 por ciento) y no se asoció a la posición (p = 0,120), localización (p = 0,225) o factor T (p = 0,339). El coeficiente de concordancia fue bajo (κ = 0,381; p < 0,001), debido a que el cambio ocurrió en el 49,03 por ciento de los pacientes. CONCLUSIONES. El cambio de estadio clínico fue de magnitud apreciable y, por tanto, tiene el potencial de inducir a la práctica de tratamientos inadecuados, tanto médicos como quirúrgicos(AU)

INTRODUCTION. Change of clinical stage of non-microcyst pulmonary cancer in comparing the pre-postoperative and postoperative periods may to have negative repercussions on the definition of therapeutical strategies. The aim of present paper was to assess the magnitude of such changes and its effect on the patient. METHODS. A retrospective study was conducted with a prospective database of 259 patients treated from January, 2002 to December, 2007. Patients with neoadjuvant therapy, palliative interventions or relapse and small cells neoplasms were excluded. The study variables were: tumor factors (T), nodules (N) and metastasis (M), tumor position and location and involved lung. Agreement coefficient allowed assessing the change magnitude and the Chi² test, the association between the two variables. RESULTS. T factor changed in 91 patients (35,1 percent) more frequent in superior lobules lesions (p = 0,04). Position wasn't associated with the change (p = 0,110). N factor was modified in 50 cases (19,3 percent). Associated with change were: lobular location (p = 0,001), involved lung (p = 0,002) and T factor (p = 0,013). The change in T factor happened in 11 patients (4,2 percent) and wasn't associated with the position (p = 0,120), location (p = 0,225) or T factor (p = 0,339). Agreement coefficient was low (κ = 0,381; p < 0,001), because of the change occurred in the 49,03 percent of patients. CONCLUSIONS. The change in clinical stage was of a significant magnitude and thus, has the potential to induce to inappropriate medical and surgical treatments practice(AU)
Descritores: Carcinoma Pulmonar de Células não Pequenas/etiologia
Neoplasias Pulmonares/epidemiologia
Estadiamento de Neoplasias
Limites: Seres Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


  2 / 2034 LILACS  
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Id: biblio-985132
Autor: Monteiro, Nonato Mendonça Lott; Rodrigues, Karla Emília de Sá; Vidigal, Paula Vieira Teixeira; Oliveira, Benigna Maria de.
Título: Carcinoma adrenal em crianças: estudo longitudinal em minas gerais, brasil / Adrenal carcinoma in children: longitudinal study in minas gerais, brazil
Fonte: Rev. Paul. Pediatr. (Ed. Port., Online);37(1):20-26, Jan.-Mar. 2019. tab.
Idioma: pt.
Resumo: RESUMO Objetivo: Analisar as características clínicas, laboratoriais e histopatológicas e o percurso até o estabelecimento do diagnóstico e do tratamento de pacientes com carcinoma de suprarrenal (CSR). Métodos: Estudo retrospectivo com 13 pacientes tratados no serviço de oncologia pediátrica do Hospital das Clínicas da Universidade Federal de Minas Gerais (HC-UFMG) entre 2004 e 2015. Resultados: A idade ao diagnóstico variou de 1,0 a 14,8 anos (mediana: 2,0 anos). As manifestações de hipercortisolismo foram identificadas em todos os casos, e as de virilização, em todas as meninas. Todos os pacientes preencheram os critérios de Weiss para diagnóstico histopatológico de CSR. A imuno-histoquímica foi realizada em 61,5% dos casos. A maioria dos pacientes apresentou doença em estádio I (76,9%). Todos foram submetidos à ressecção tumoral total. Dois pacientes (estádios III e IV) receberam quimioterapia associada ao mitotano. O único óbito observado foi do paciente com doença em estádio IV. A probabilidade de sobrevida global para todo o grupo aos 5,0 anos foi de 92,3±7,4%. A mediana de tempo entre o início dos sintomas e o diagnóstico foi de 9,5 meses, e de 6,0 meses entre a primeira consulta e o início do tratamento. Conclusões: A baixa idade ao diagnóstico, o predomínio de casos com doença localizada e a ressecção tumoral completa - com apenas um caso de ruptura de cápsula tumoral - são possivelmente a explicação para a evolução favorável da população estudada. O longo percurso entre o início dos sintomas e o diagnóstico sugere a importância da capacitação dos pediatras para o reconhecimento precoce dos sinais e dos sintomas do CSR.

ABSTRACT Objective: To analyze clinical, laboratory and histopathological features and the path to diagnosis establishment and treatment of patients with adrenal carcinoma (AC). Methods: Retrospective study with 13 patients assisted at the pediatric oncology service of Hospital das Clínicas, Universidade Federal de Minas Gerais, Brazil, between 2004 and 2015. Results: Age at diagnosis ranged from 1.0 to 14.8 years (median: 2.0 years). Manifestations of hypercortisolism were identified in all cases and virilization in all girls. All patients met the Weiss criteria to AC histopathological diagnosis. Immunohistochemistry was performed in 61.5% of the cases. Most patients had stage I disease (76.9%). All subjects were submitted to total tumor resection. Two patients (stages III and IV disease) received chemotherapy associated to mitotane. The only death case was that of a patient with stage IV disease. The probability of overall survival for the entire group up to 5.0 years was 92.3±7.4%. The median time between the onset of symptoms and diagnosis was 9.5 months, and 6.0 months between first visit and start of treatment. Conclusions: Low age at diagnosis, predominance of cases with localized disease and complete tumor resection - with only one case of tumor capsule rupture - can possibly explain the favorable evolution of the studied population. The long period between onset of symptoms and diagnosis highlights the importance of training pediatricians for early recognition of AC signs and symptoms.
Descritores: Antineoplásicos/uso terapêutico
-Avaliação de Processos e Resultados (Cuidados de Saúde)
Brasil/epidemiologia
Carcinoma/mortalidade
Carcinoma/patologia
Carcinoma/terapia
Estudos Retrospectivos
Neoplasias das Glândulas Suprarrenais/mortalidade
Neoplasias das Glândulas Suprarrenais/patologia
Neoplasias das Glândulas Suprarrenais/terapia
Glândulas Suprarrenais/patologia
Adrenalectomia/métodos
Adrenalectomia/estatística & dados numéricos
Síndrome de Cushing/diagnóstico
Síndrome de Cushing/etiologia
Detecção Precoce de Câncer
Tempo para o Tratamento/estatística & dados numéricos
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Feminino
Lactente
Pré-Escolar
Criança
Adolescente
Responsável: BR1.1 - BIREME


  3 / 2034 LILACS  
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Id: biblio-949949
Autor: Amorim, Gustavo Moreira; Corbellini, João Paulo Niemeyer; Quintella, Danielle Carvalho; Cuzzi, Tullia; Ramos-e-Silva, Márcia.
Título: Evaluation of the Cutaneous Lymphoma International Prognostic Index in patients with early stage mycosis fungoides
Fonte: An. bras. dermatol;93(5):680-685, Sept.-Oct. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: Mycosis fungoides (MF) is the most common subtype of cutaneous T-cell lymphoma. TNMB system is the staging method used in MF, and it not only guides therapeutic management, but represents the main prognostic factor. In order to improve the prognostic evaluation, the Cutaneous Lymphoma International Prognostic Index (CLIPi) was proposed. Objective: To evaluate the performance of CLIPi score for prognostic analysis in patients with early stage MF. Methods: This is a retrospective cross-sectional observational study, with exploratory analysis. The outcome variables were disease progression and related death. Results: One hundred and two patients were stratified according to CLIPi score, being the majority classified as low risk. Patients with intermediate or high risk presented disease progression more frequently than those with low risk (PR: 1.2 / p = 0.004 / 95%CI: 1.0 - 1.6). The same did not occur with the variable related death. In addition, survival rates were not consistent with risk stratification. Study Limitations: Small sample and its retrospective analysis. Conclusions: Since CLIPi score was proposed, four other studies that we could consult showed conflicting results, similar to the present study. Further studies are necessary for a recommendation of its use.
Descritores: Neoplasias Cutâneas/patologia
Micose Fungoide/patologia
-Prognóstico
Neoplasias Cutâneas/mortalidade
Brasil/epidemiologia
Estudos Transversais
Taxa de Sobrevida
Estudos Retrospectivos
Seguimentos
Linfoma Cutâneo de Células T/mortalidade
Linfoma Cutâneo de Células T/patologia
Micose Fungoide/mortalidade
Síndrome de Sézary/patologia
Progressão da Doença
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Estudo Observacional
Responsável: BR1.1 - BIREME


  4 / 2034 LILACS  
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Id: biblio-949925
Autor: Steglich, Raquel Bissacotti; Cardoso, Silvana; Gaertner, Maria Helena da Costa Naumann; Coelho, Karina Munhoz de Paula Alves; Cestari, Tania Ferreira; Franco, Selma Cristina.
Título: Differences in the diagnosis of primary cutaneous melanoma in the public and private healthcare systems in Joinville, Santa Catarina State, Brazil
Fonte: An. bras. dermatol;93(4):507-512, July-Aug. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: Cutaneous melanoma accounts for up to 80% of deaths caused by skin cancer. Diagnostic suspicion and access to medical care and early intervention in suspected cases is vital to the patient's prognosis. Objectives: To compare demographic and histopathological characteristics of primary cutaneous melanoma diagnosed in the public healthcare system (Sistema Único de Saúde SUS) and the private system in Joinville, Santa Catarina State, Brazil. Methods: This cross-sectional retrospective study analyzed primary cutaneous melanoma cases recorded from 2003 to 2014 in the resident population of Joinville. Ethical approval was obtained from the local Research Ethics Committee. Results: 893 cases of primary cutaneous melanoma were identified. Patients in the private system were mostly younger, while there were more elderly patients in the public healthcare system (p <0.001). There was no statistically significant association between type of care (public/private) and gender or presence of multiple primary cutaneous melanomas. Histological diagnosis of superficial spreading melanoma was more common in patients treated in private healthcare, while nodular melanoma was more frequent in patients in the public healthcare system (p <0.001). Mean Breslow depth in patients treated in private healthcare was 1.35mm, compared to 2.72mm in the public system (p <0.001). Study limitations: This was a retrospective study using secondary databases. Conclusions: thin cutaneous melanoma (in situ cutaneous melanoma and Breslow T1) showed the strongest association with the private healthcare system, while thick cutaneous melanoma was more frequent in the public system (Breslow category T3 and T4) (p <0.001).
Descritores: Neoplasias Cutâneas/diagnóstico
Melanoma/diagnóstico
-Prognóstico
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/terapia
Neoplasias Cutâneas/epidemiologia
Brasil/epidemiologia
Estudos Transversais
Estudos Retrospectivos
Setor Público/estatística & dados numéricos
Setor Privado/estatística & dados numéricos
Melanoma/patologia
Melanoma/terapia
Melanoma/epidemiologia
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Feminino
Recém-Nascido
Lactente
Pré-Escolar
Criança
Adolescente
Adulto
Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


  5 / 2034 LILACS  
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Id: lil-584335
Autor: García Rodríguez, Miguel Emilio.
Título: Estadificación y valoración mediastínica del cáncer del pulmón / Staging and mediastinal assessment of lung cancer
Fonte: Rev. cuba. cir;49(4):82-93, oct.-dic. 2010.
Idioma: es.
Resumo: El cáncer de pulmón se considera la más letal de las neoplasias, tanto en los hombres como en las mujeres, y supera la suma de todas las muertes por cáncer de colon, próstata y mama. En el momento del diagnóstico más del 40 por ciento de los pacientes tienen una enfermedad localmente avanzada, en la que las posibilidades de curación son escasas y la supervivencia a los 5 años es de apenas un 15 por ciento. La estadificación de la enfermedad, así como la valoración mediastínica es crucial para realizar un tratamiento correcto, establecer pronósticos y realizar investigaciones que conlleven a una conducta adecuada ante estos pacientes. Con el objetivo de actualizar el tema se realizó una revisión en varias bases de datos en inglés: Pubmed, Medline y Ebsco, utilizando las palabras clave: lung cancer staging, mediastinal lymphonode excision y lung carcinoma(AU)

The lung cancer is considered the most lethal of neoplasias both in men and women and it is the highest figure of all death by colon, prostate and breast deaths. At diagnosis more than the 40 percent of patients have a locally advanced disease with scarce possibilities of cure and the 5-years survival is hardly of a 15 percent. Disease's staging as well as the mediastinal assessment is crucial to a proper diagnosis, to establish prognoses and the carry out researches leading to a appropriate behavior in these cases. The objective of present paper was to update on this subject authors made search in some databases in English language: Pubmed, Medline and Ebsco, using lung cancer staging, mediastinal lymphonode excision and lung carcinoma as key words(AU)
Descritores: Estadiamento de Neoplasias/métodos
Neoplasias Pulmonares/patologia
Neoplasias do Mediastino/secundário
-Invasividade Neoplásica
Limites: Seres Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


  6 / 2034 LILACS  
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Id: biblio-1038278
Autor: Suzuki, Nathalie Mie; Saraiva, Maria Isabel Ramos; Capareli, Gabriela Cunha; Castro, Luiz Guilherme Martins.
Título: Histologic review of melanomas by pathologists trained in melanocytic lesions may change therapeutic approach in up to 41 9% of cases
Fonte: An. bras. dermatol;93(5):752-754, Sept.-Oct. 2018. tab, graf.
Idioma: en.
Resumo: Abstract: Melanoma Guidelines of the Brazilian Dermatology Society recommend histologic review by pathologists trained in melanocytic lesions whenever possible. Out of 145 melanoma cases identified at a private clinic in São Paulo/Brazil, 31 that had been submited to histologic review were studied to evaluate whether revision had led to change in therapeutic approach.. Differences in original/reviewed reports were found in 58.1% (n=18) of the reports, leading to changes in therapeutic approach in 41.9% (n=13). Change in diagnosis was observed in 6 out of 31 (19,3%) cases. These findings suggest that second opinion by pathologists trained in melanocytic lesions is likely to show significant differences from the original report.
Descritores: Patologia Clínica/normas
Patologistas
Melanócitos/patologia
Melanoma/patologia
-Encaminhamento e Consulta
Brasil
Variações Dependentes do Observador
Estudos Retrospectivos
Técnicas Histológicas/métodos
Técnicas Histológicas/normas
Dermatologia/normas
Dermatologistas
Melanoma/diagnóstico
Melanoma/terapia
Estadiamento de Neoplasias/classificação
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


  7 / 2034 LILACS  
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Id: biblio-973636
Autor: Ruiz-Rivero, Juncal; Horcajada-Reales, Celia; Tardío, Juan C; Borbujo-Martínez, Jesús Manuel.
Título: Multiple spider telangiectasias in a breast cancer patient on T-DM1 treatment
Fonte: An. bras. dermatol;93(6):938-939, Nov.-Dec. 2018. graf.
Idioma: en.
Descritores: Telangiectasia/etiologia
Neoplasias da Mama/tratamento farmacológico
Erupção por Droga/etiologia
Trastuzumab/efeitos adversos
Antineoplásicos Imunológicos/efeitos adversos
-Telangiectasia/patologia
Neoplasias da Mama/química
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico
Erupção por Droga/patologia
Receptor ErbB-2
Trastuzumab/uso terapêutico
Antineoplásicos Imunológicos/uso terapêutico
Maitansina/análogos & derivados
Maitansina/efeitos adversos
Maitansina/uso terapêutico
Estadiamento de Neoplasias
Limites: Seres Humanos
Feminino
Meia-Idade
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


  8 / 2034 LILACS  
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Id: biblio-1038300
Autor: Germano, Andressa; Cardili, Leonardo; Carapeto, Fernando Cintra Lopes; Landman, Gilles.
Título: BRAFV600E and KIT immunoexpression in early-stage melanoma
Fonte: An. bras. dermatol;94(4):458-460, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: Abstract: Melanoma is widely known as the most lethal skin cancer. Specific tumor-related mortality can be significantly reduced if diagnosis and treatment are properly performed during initial phases of the disease. The current search for biomarkers in early-stage melanomas is a high-priority challenge for physicians and researchers. We aimed to assess the immunoexpression of BRAFV600E and KIT in a case series consisting of 44 early-stage melanomas. Formalin-fixed paraffin-embedded samples were systematically evaluated using a semi-quantitative method based on scores of percentage and intensity for immunostained tumor cells. We observed significant concordance between BRAFV600E and KIT immunoexpression in thin invasive melanomas. Our findings corroborate previous evidence showing abnormal expression of proteins associated with MAPK intracellular signaling pathway in early-stage melanomas.
Descritores: Neoplasias Cutâneas/patologia
Proteínas Proto-Oncogênicas c-kit/análise
Proteínas Proto-Oncogênicas B-raf/análise
Melanoma/patologia
-Imuno-Histoquímica
Estudos Retrospectivos
Progressão da Doença
Proteínas Proto-Oncogênicas c-kit/genética
Proteínas Quinases Ativadas por Mitógeno/análise
Proteínas Proto-Oncogênicas B-raf/genética
Mutação
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


  9 / 2034 LILACS  
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Id: lil-792425
Autor: Sehitoglu, Ibrahim; Bedir, Recep; Cure, Erkan; Cure, Medine Cumhur; Yuce, Suleyman; Dilek, Nursel.
Título: Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma
Fonte: An. bras. dermatol;91(4):430-435, July-Aug. 2016. tab, graf.
Idioma: en.
Resumo: Abstract: Background: c-Kit is a proto-oncogene that encodes tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker, providing information on platelet function and diameter. Objective: To investigate c-Kit expression and intensity in patients with Kaposi's sarcoma (KS) and to investigate the relation between Ki-67 proliferation and MPV. Methods: A total of 32 patients, diagnosed with classic cutaneous KS, were included in this study. We reevaluated the histopathological reports with the preparations, confirmed the diagnosis and then determined the patients' histopathological stages. c-Kit expression and Ki-67 proliferation were investigated immunohistochemically in KS cases, while MPV in all cases was checked. Results: Although c-Kit expression was detected in 22 cases (68.8%), it was not expressed in 10 cases (31.2%). We detected 8 cases with + (25%), 6 with ++ (18.8%) and 8 with +++ (25%). Ki-67 expression was 5.0% (min-max 1.0-20.0). Relapse was observed in 5 cases (15.6%) out of 32. There was positive correlation between c-Kit expression and MPV (rs=0.598, p<0.001), and between c-Kit intensity and MPV (rs=0.588, p<0.001). Conclusion: c-Kit is highly positive in KS. c-Kit positivity indicates a high risk of tumor growth, invasion and relapse. Furthermore, c-Kit expression stimulates megakaryocytes to release young and large thrombocytes into the periphery. Thus, high MPV, c-Kit expression and immunostaining intensity indicate high invasion and relapse in KS subjects.
Descritores: Sarcoma de Kaposi/patologia
Neoplasias Cutâneas/patologia
Proteínas Proto-Oncogênicas c-kit/análise
Antígeno Ki-67/análise
Volume Plaquetário Médio
-Valores de Referência
Plaquetas/patologia
Imuno-Histoquímica
Biomarcadores Tumorais
Fatores Sexuais
Estatísticas não Paramétricas
Recidiva Local de Neoplasia/patologia
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


  10 / 2034 LILACS  
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Id: biblio-838029
Autor: Wakiyama, Thweicyka Pinheiro; França, Maria Laura Marconi; Carvalho, Larissa Pierri; Marques, Mariangela Esther Alencar; Miot, Hélio Amante; Schmitt, Juliano Vilaverde.
Título: Initial basal cell carcinomas diagnosed in the National Campaign for Skin Cancer Prevention are smaller than those identified by the conventional medical referral system
Fonte: An. bras. dermatol;92(1):26-29, Jan.-Feb. 2017. tab, graf.
Idioma: en.
Resumo: Abstract: BACKGROUND: Basal cell carcinoma is the malignant tumor most often diagnosed in the National Campaign for Skin Cancer Prevention (NCSCP). Little is known about the profile of these lesions compared to the profile of lesions diagnosed by conventional routes of public dermatological care. OBJECTIVE: To identify if basal cell carcinomas identified in prevention campaigns and referred to surgery are smaller than those routinely removed in a same medical institution. METHODS: Cross-sectional study including tumors routed from 2011-2014 campaigns and 84 anatomopathological reports of outpatients. RESULTS: The campaigns identified 223 individuals with suspicious lesions among 2,531 examinations (9%), with 116 basal cell carcinomas removed. Anatomopathological examinations revealed that the primary lesions identified in the national campaigns were smaller than those referred to surgery by the conventional routes of public health care (28 [13-50] x 38 [20-113] mm2, p <0.01). On the other hand, after a mean follow-up of 15.6 ± 10.3 months, 31% of cases identified in campaigns showed new basal cell carcinoma lesions. STUDY LIMITATIONS: Retrospective study and inaccuracies in the measurements of the lesions. CONCLUSIONS: The NCSCP promotes an earlier treatment of basal cell carcinomas compared to patients referred to surgery by the conventional routes of public health care, which can result in lower morbidity rates and better prognosis.
Descritores: Neoplasias Cutâneas/diagnóstico
Carcinoma Basocelular/diagnóstico
Programas de Rastreamento
-Encaminhamento e Consulta
Neoplasias Cutâneas/patologia
Neoplasias Cutâneas/epidemiologia
Brasil/epidemiologia
Carcinoma Basocelular/patologia
Carcinoma Basocelular/epidemiologia
Estudos Transversais
Estudos Retrospectivos
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Feminino
Idoso
Responsável: BR1.1 - BIREME



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