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Pesquisa : E02.095.465 [Categoria DeCS]
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Id: biblio-997947
Autor: Alvarenga, Nelson; Burgos, Christa; Villalba, Iris; Giménez, Vivian; Carpinelli, María Mercedes; Sotelo, Pablo H; Cáceres, Andrea; Langjahr, Patricia.
Título: Extractos vegetales de tres especies del género Baccharis inducen la proliferación de células mononucleares humanas / Plant extracts of three species of the genus Baccharis induce human mononuclear cells proliferation
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);16(2):12-20, Ago. 2018. ilus.
Idioma: es.
Resumo: Las plantas de uso en medicina tradicional constituyen una fuente importante de compuestos con actividad inmunomoduladora; entre ellas las especies del género Baccharis, conocidas popularmente como "Jaguareteka´a" en nuestro país, son ampliamente empleadas. En este estudio se evaluó la actividad inmunomoduladora de extractos metanólicos de tres especies del género Baccharis (B. trimera, B. notosergilay B. punctulata) sobre la proliferación de células mononucleares humanas de sangre periférica. Los extractos de las tres especies estudiadas estimularon la proliferación de las células mononucleares. Específicamente, el extracto de B. notosergila estimuló la proliferación celular a todas las concentraciones probadas (5, 10, 25 y 50 µg/mL), mientras que los extractos de B. trimera y B. punctulata mostraron este efecto a 5 y 10 µg/mL. Además, por presentar mayor inducción de la proliferación, se realizó un fraccionamiento con diferentes solventes del extracto metanólico de B. notosergila y B. punctulata. La fracción de acetato de etilo de ambos extractos vegetales aumentó la proliferación celular, sugiriendo que compuestos de polaridad media son los responsables de esta actividad. Estos resultados demuestran que los extractos de B. trimera, B. notosergila y B. punctulata poseen actividad inmunomoduladora sobre células mononucleares humanas y servirán de base a otros estudios para determinar el o los componentes activos de los extractos sobre el sistema inmune(AU)

Plants used in traditional medicine are an important source of compounds with immunomodulatory activity. Species of the genus Baccharis, popularly known as "Jaguareteka'a" in our country, are used in folk medicine for the treatment of liver, gastrointestinal, inflammatory and infectious diseases. In this study, we evaluated the immunomodulatory activity of methanolic extracts of three species of the genus Baccharis (B. trimera, B. notosergila and B. punctulata) on the proliferation of human peripheral blood mononuclear cells. Extracts of the three species studied stimulated the proliferation of mononuclear cells. The extract of B. notosergila stimulated cell proliferation at all concentrations tested, while extracts of B. trimera and B. punctulata stimulated at 5 and 10 µg/mL. In addition, we carried out a separation with different solvents of the methanolic extract of B. notosergila and B. punctulata. The ethyl acetate fraction of both plant extracts induced the proliferation of immune cells. These results show that the extracts of B. trimera, B. notosergila and B. punctulata had immunomodulatory activity on human mononuclear cells. Future work will be required to identify the components responsible for the activity on the immune system(AU)
Descritores: Células Sanguíneas/efeitos dos fármacos
Extratos Vegetais/farmacologia
Baccharis
Proliferação Celular/efeitos dos fármacos
Imunomodulação/efeitos dos fármacos
-Plantas Medicinais
Linfócitos/efeitos dos fármacos
Sobrevivência Celular
Responsável: PY3.1 - Biblioteca


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Id: biblio-977831 LILACS-Express
Autor: Fernandes, Eduardo Vignoto; Estanislau, Celio; Venancio, Emerson José.
Título: Moderate intensity physical exercise: psychoneuroimmunological aspects / Exercício físico de intensidade moderada: aspectos psiconeuroimunológicos / Ejercicio físico de intensidad moderada: aspectos psiconeuroinmunológicos
Fonte: Rev. bras. med. esporte;24(5):395-398, Sept.-Oct. 2018. graf.
Idioma: en.
Resumo: The literature presents several instances of interaction between the nervous system (NS) and the immune system (IS). These interactions are promoted by several molecules, such as cytokines and hormones, with modulating action for both the NS and IS. In this sense, the two systems may influence each other: changes in behavior may be accompanied by alterations in the IS (e.g., immunosuppression) and immunological disorders, such as infections, may modulate behavior (e.g., anxiety and depression). Considering that chronic stress, in addition to affecting behavior, also modulates the IS and that there is evidence that moderate intensity physical exercise (PE) protects physical and mental health, the objective of this review is to explore the influence of moderate-intensity PE on behavior and immunity. Level of Evidence V; Expert opinion.

A literatura apresenta diversas instâncias de interação entre o sistema nervoso (SN) e o sistema imunológico (SI). Essas interações são promovidas por diversas moléculas, como citocinas e hormônios com ação moduladora tanto para o SN quanto o SI. Nesse sentido, os dois sistemas podem ter influência mútua: as alterações do comportamento podem ser acompanhadas por alterações do SI (por exemplo, imunossupressão), e distúrbios imunológicos como infecções, podem modular o comportamento (por exemplo, ansiedade e depressão). Considerando que o estresse crônico, além de afetar o comportamento, modula o SI e que há evidências de que o exercício físico (EF) de intensidade moderada ajuda a proteger a saúde física e mental, o objetivo da presente revisão é explorar a influência do EF de intensidade moderada sobre o comportamento e a imunidade. Nível de Evidência V; Opinião do especialista.

La literatura presenta diversas instancias de interacción entre el sistema nervioso (SN) y el sistema inmune (SI). Estas interacciones son promovidas por diversas moléculas, como citosinas y hormonas, con acción moduladora tanto para el SN como para el SI. En este sentido, los dos sistemas pueden influenciarse mutuamente: los cambios en el comportamiento pueden ser acompañados por alteraciones en el SI (inmunosupresión) y los disturbios inmunológicos, como infecciones, pueden modular el comportamiento (ej. ansiedad y depresión). Considerando que el estrés crónico, además de impactar el comportamiento, también modula el SI y que hay evidencias de que el ejercicio físico (EF) de intensidad moderada es un protector para la salud física y mental, el objetivo de la presente revisión es explotar la influencia del EF de intensidad moderada en el comportamiento y la inmunidad. Nivel de Evidencia V; Opinión del especialista.
Descritores: Condicionamento Físico Animal/fisiologia
Estresse Psicológico/prevenção & controle
Psiconeuroimunologia
Exercício/fisiologia
Imunomodulação
Sistema Imunitário/fisiologia
-Hidrocortisona
Ratos Sprague-Dawley
Depressão/prevenção & controle
Limites: Seres Humanos
Animais
Masculino
Feminino
Idoso
Camundongos
Ratos
Adulto Jovem
Tipo de Publ: Revisão
Responsável: BR14.1 - Biblioteca Central


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Id: lil-623779
Autor: Normier, G; Pinel, A. M; Domzig, W; Dussourd D'Hinterland, L.
Título: Immunomodulation by microbial ribosomes
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.2):163-172, 1987. graf, ilus.
Idioma: en.
Conferência: Apresentado em: International Symposium on Immunomodulators: Biology and Therapeutic Applications, Rio de Janeiro, Apr. 26-30, 1987.
Resumo: Over the past twenty years, many authors have reported evidence of the immunoprotective capacity of ribosomes isolated from bacteria, fungi and parasites. Since 1971 we have explored the protective capacity of ribosomes isolated from a large variety of microorganisms responsible for human and animal diseases. More recently, using monoclonal antibodies raised against ribosomes and then selected for their ability to confer passive immunity to mice, we have studied the mechanism of the protection induced by ribosomes. These studies, in parallel with the development of a technology for the large scale production of ribosomes, have allowed us to achieve a new regard for ribosomal vaccines for use in human. The general concept of ribosomal vaccines in presented and examples of two such vaccines are described with data on the specific protection that they induce in mice against experimental infections with Klebsiella peneumoniae, Streptococcus pneumoniae, S. pyogenes and Haemophilus influenzae for the first one, and against Candida albicans type A and type B for the second one. Because of their high immunogenicity and their innocuity these vaccines represent a decisive improvement over classical microbial vaccines.
Descritores: Ribossomos/genética
Rodopsinas Microbianas/uso terapêutico
Imunomodulação/genética
-Fatores Imunológicos
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-623767
Autor: Ablin, Richard J; Polgar, Janos; Gonder, Maurice J.
Título: Endogenous and exogenously-induced immunomodulation of tumour-host responsiveness
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.2):81-93, 1987. tab, graf.
Idioma: en.
Conferência: Apresentado em: International Symposium on Immunomodulators: Biology and Therapeutic Applications, Rio de Janeiro, Apr. 26-30, 1987.
Projeto: U. S. National Institute of Health; . U. S. National Institutes of Health. National Cancer Institute. International Cancer Research Data Bank Programme.
Resumo: In spite of the availability of multiple effector mechanisms of the immune system to combat tumour growth and metastases, their impairment frequently accompanies the appearance of cancer. Factors contributing to this impairment may be related to properties of the host and/or the tumour itself and may be with respect to their origin -endogenous or exogenour. Based on the unique biological behavior of prostate cancer (PCa), and its apparent escape from immune surveillance in the presence of tumour immuno genicity, continuing investigation of endogenous and exogenous factors thought to be relevant to its pathogenesis have been made. For this purpose further studies of the suggested role of human seminal plasma (SePl) and the synthetic oestrogen, diethylstiboestrol (DES), as representative endogenous and exogenous immunomodulatory factors (IMF) of tumour-host responsiveness, together with evaluation of human prostatic tissue extracts and leuprolide (the luteinizing-hormone-releasing-hormone proposed as an alternate to DES therapy) have been made by evaluating their effect on the lytic activity of natural killer (NK) cells. SePl and prostate extracts significantly suppressed NK cell lysis. Physicochemical studies suggest SePl and prostate IMF to be associated with high and low molecular weight macromolecules; and implicate the participation of transglutaminase and prostaglandins. Comparative study of therapeutic levels of DES vs. leuprolide on NK cell lysis demonstrated significant suppression by DES vs. a negligible effect of leuprolide. Metastases are highly prevalent in PCa, and contribute significantly to its morbidity and mortality. Further knowledge of the range of effects of endogenous and exogenous IMF on effector mechanisms of tumour-host responsiveness, to include suppression of NK cells, and elucidation of their nature, may contribute toward our understanding of the unique biological behavior of tumours of the prostate, in addition to improvement in their clinical management.
Descritores: Neoplasia Residual
Imunomodulação/efeitos dos fármacos
Imunomodulação/imunologia
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-623765
Autor: Plotnikoff, Nicholas P; Miller, Gerald C; Nimeh, Nadim F; Wybran, Joseph.
Título: Methionine enkephalin: immunomodulator in normal volunteers, cancer and AIDS patients
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.2):67-73, 1987. tab, graf.
Idioma: en.
Conferência: Apresentado em: International Symposium on Immunomodulators: Biology and Therapeutic Applications, Rio de Janeiro, Apr. 26-30, 1987.
Resumo: Clinical studies of the immunological effects of methionine enkephalin in normal volunteers, cancer, and AIDS patients are summarized. The major immunology changes seen were increases in T cell subsets, natural killer activity, as well as mitogen blastogenesis. Clinically, the cancer and ARC patients did not develop infections.
Descritores: Encefalina Metionina/imunologia
Encefalina Metionina/uso terapêutico
Imunomodulação/imunologia
-Síndrome de Imunodeficiência Adquirida/terapia
Voluntários Saudáveis/classificação
Neoplasias
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: lil-623764
Autor: Ader, Robert.
Título: The immunomodulatory effects of behavior
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.2):53-65, 1987. graf.
Idioma: en.
Conferência: Apresentado em: International Symposium on Immunomodulators: Biology and Therapeutic Applications, Rio de Janeiro, Apr. 26-30, 1987.
Resumo: Evidence is presented indicating that behavioral conditioning techniques can be used to suppress and enhance antibody- and cell-mediated immune responses. Application of conditioning techniques in the pharmacotherapy of autoimmune disease in New Zeland mice resulted in a delay in the onset of lupus using a cumulative dose of immunosuppressive drug that was not, by itself, sufficient to alter the course of the autoimmune disease. Convesely, behavioral studies in lupus-proneMrl lpr (lpr and Mrl +/+ mice suggest further that immune status can influence behavior and that such behavior may serve to correct and immunologic dysregulation. Theses data are interpreted to indicate behavior can serve an immunomodulatory function.
Descritores: Imunomodulação/fisiologia
Imunomodulação/imunologia
-Comportamento/fisiologia
Limites: Seres Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1001577
Autor: Zhang, Yang; Liu, Yang; Yang, Xiudong; Cui, Hao; Xu, Xiaoxiao; Mao, Liping; Zhou, Hongli.
Título: Antioxidant and immunomodulatory activities of Oviductus ranae in mice
Fonte: Braz. J. Pharm. Sci. (Online);54(4):e17751, 2018. tab, graf.
Idioma: en.
Resumo: Oviductus ranae (OR) is a traditional Chinese medicine, which was first recorded in the Compendium of Materia Medica in the Ming Dynasty. OR contains high amounts of proteins and elicits therapeutic effects on neurasthenia, insomnia, and respiratory symptoms, which are related to oxidative stress and immunodeficiency. This study aimed to obtain the potential of OR for the development of functional food possessing antioxidant and immune-enhancement functions in the same dose. In antioxidant evaluation, OR can significantly decrease malondialdehyde and protein carbonyls (P < 0.05, P < 0.01) and significantly increase total superoxide dismutase and glutathione in a dose-dependent manner (P< 0.05, P < 0.01) against ethanol-induced oxidative stress in mice at 0.1, 1.0, and 3.0 g/kg BW. In immunomodulatory evaluation, OR could significantly enhance the phagocytosis of liver macrophages (P < 0.05, P < 0.01), delayed-type hypersensitivity response (P < 0.05, P < 0.01), hemolytic activity (P < 0.05), antibody-producing cells (P < 0.05), and natural killer cell activity (P < 0.05) in the same dose range described in antioxidant evaluation compared with those in the normal control. OR slightly influenced lymphocyte proliferation, peritoneal macrophage phagocytosis, and immune organ indices in mice. Thus, 3.0 g/kg BW OR showed potential for the development of functional food with antioxidant and immune-enhancement activities
Descritores: Medicina Tradicional Chinesa/instrumentação
Antioxidantes/análise
-Alimento Funcional/análise
Imunomodulação
Limites: Animais
Masculino
Camundongos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: lil-670462
Autor: Machado, Cíntia de Vasconcellos; Telles, Paloma Dias da Silva; Nascimento, Ivana Lucia Oliveira.
Título: Immunological characteristics of mesenchymal stem cells
Fonte: Rev. bras. hematol. hemoter;35(1):62-67, 2013.
Idioma: en.
Resumo: Although bone marrow is the main source, mesenchymal stem cells have already been isolated from various other tissues, such as the liver, pancreas, adipose tissue, peripheral blood and dental pulp. These plastic adherent cells are morphologically similar to fibroblasts and have a high proliferative potential. This special group of cells possesses two essential characteristics: self-renewal and differentiation, with appropriate stimuli, into various cell types. Mesenchymal stem cells are considered immunologically privileged, since they do not express costimulatory molecules, required for complete T cell activation, on their surface. Several studies have shown that these cells exert an immunosuppressive effect on cells from both innate and acquired immunity systems. Mesenchymal stem cells can regulate the immune response in vitro by inhibiting the maturation of dendritic cells, as well as by suppressing the proliferation and function of T and B lymphocytes and natural killer cells. These special properties of mesenchymal stem cells make them a promising strategy in the treatment of immune mediated disorders, such as graft-versus-host disease and autoimmune diseases, as well as in regenerative medicine. The understanding of immune regulation mechanisms of mesenchymal stem cells, and also those involved in the differentiation of these cells in various lineages is primordial for their successful and safe application in different areas of medicine.
Descritores: Doenças Autoimunes/terapia
Células-Tronco
Diferenciação Celular
Imunomodulação
Células Mesenquimais Estromais/imunologia
Sistema Imunitário
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM


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Id: lil-784133
Autor: Fonte Galindo, Luis; Baldriche Acosta, Jessica; Sarracent Pérez, Jorge; Hernández Barrios, Yisel; Fong González, Annia.
Título: Regulación por helmintos de las respuestas inmunitarias del hospedero / Helminth regulation of host immune responses
Fonte: Rev. cuba. med. trop;68(1):0-0, abr. 2016. ilus.
Idioma: es.
Resumo: Introducción: durante las últimas dos décadas se ha producido una rápida acumulación de conocimientos sobre la inmunología de las helmintosis. La información ahora disponible permite un mejor entendimiento de los mecanismos defensivos del hombre contra la infección por helmintos. Otra área del saber sobre la inmunología de las helmintosis, la relacionada con la regulación de las respuestas inmunitarias del hospedero ejercida por el parásito, con sus muy disímiles implicaciones clínicas y epidemiológicas, también se ha beneficiado de la expansión cognoscitiva de los últimos años. Objetivos: revisar lo publicado sobre las evidencias, mecanismos y consecuencias de la regulación de las respuestas inmunitarias del hospedero ejercida por los helmintos. Métodos: con el auxilio de diferentes buscadores electrónicos, se realiza una revisión de los artículos sobre helmintos, helmintosis y regulación de las respuestas inmunitarias del hospedero publicados durante el período 1995-2015. Algunas monografías y artículos originales fechados con anterioridad al intervalo mencionado también fueron consultados. Resultados: se expone y analiza, y hasta donde es posible se sistematiza, la información colectada sobre los temas seleccionados. Conclusiones: datos epidemiológicos, clínicos y experimentales evidencian que los helmintos logran modular las respuestas inmunitarias de sus respectivos hospederos y con ello sobrevivir en aquellos. Adicionalmente, la modulación de las respuestas inmunitarias del hospedero tiene importantes consecuencias clínicas y epidemiológicas que, en aras de una práctica médica de mejor calidad, deben ser conocidas por los profesionales relacionados con el diagnóstico, tratamiento y control de estas parasitosis(AU)

Introduction: the last two decades have witnessed a swift accumulation of knowledge about the immunology of helminthiases. The information now available allows to better understand human defense mechanisms against helminth infection. Another area of knowledge about the immunology of helminthiases which has also benefited from such recent expansion of knowledge is the regulation of host immune responses by the parasite, with its great variety of clinical and epidemiological implications. Objectives: review publications about the evidence, mechanisms and consequences of the regulation of host immune responses by helminths. Methods: using various search engines, a review was conducted of papers about helminths, helminthiasis and regulation of host immune responses published from 1995 to 2015. Several monographs and original papers dated before that period were also consulted. Results: the information gathered about the topics selected is presented, analyzed and whenever possible systematized. Conclusions: epidemiological, clinical and experimental data show that helminths can modulate the immune responses of their hosts and thus survive within them. Additionally, modulation of host immune responses has important clinical and epidemiological consequences which should be known by professionals related to the diagnosis, treatment and control of these parasitic diseases in order to improve the quality of medical practice(AU)
Descritores: Interações Hospedeiro-Patógeno/imunologia
Imunomodulação
Helmintíase/imunologia
Limites: Seres Humanos
Masculino
Feminino
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-909784
Autor: Caraballo, Luis.
Título: El incremento de las enfermedades alérgicas y su impacto en salud pública / The increase of allergic diseases and their impact on public health
Fonte: Medicina (Bogotá);40(1(120)):25-30, Ene-Mar, 2018.
Idioma: es.
Resumo: IntroducciónLa frecuencia de las enfermedades alérgicas y otras enfermedades crónicas no infecciosas ha aumentado durante los últimos años en la mayoría de los países donde se tienen registros epidemiológicos y varias de ellas se han convertido en problemas de salud pública. Estos pro-cesos tienen un componente inmunológico importante y para explicar su incremento se han propuesto varias hipótesis, algunas relacionadas con los cambios ambientales derivados del desarrollo económico y los avances de la medicina y salud pública y sus repercusiones sobre la maduración y la homeostasis del sistema inmunológico. Los enfoques, investigaciones, publicaciones e informes sobre este problema pueden servir de ejemplo para valorar las rela-ciones entre la comunidad científica y los gobiernos y en particular entre los investigadores colombianos y las entidades gubernamentales de salud pública

AbstractFrequency of allergic and other chronic non-infectious diseases has increased in recent years in most countries where epidemiological records are available and several of them have be-come public health problems. These processes have an important immunological component and to explain their increase, several hypotheses have been proposed, some related to envi-ronmental changes derived from economic development and advances in medicine and public health and their repercussions on the maturation and homeostasis of the immune system. The approaches, research, publications and reports on this problem can serve as an example to assess the relationships between the scientifi c community and governments and in particular between Colombian researchers and government public health entities.
Descritores: Sistema Imunitário
-Helmintos
Imunomodulação
Responsável: CO102



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