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Id: biblio-1130509
Autor: Brunaldi, Vítor Ottoboni; Brunaldi, José Eduardo; Vollet-Filho, José Dirceu; Brunaldi, Mariangela Ottoboni; Ardengh, José Celso; Bagnato, Vanderlei Salvador; Dos-Santos, José Sebastião; Kemp, Rafael.
Título: Photodynamic therapy of extrahepatic cholangiocarcinoma using digital cholangioscopy / Terapia fotodinâmica em colangiocarcinoma extra-hepático utilizando colangioscopia digital
Fonte: ABCD arq. bras. cir. dig;33(1):e1490, 2020. graf.
Idioma: en.
Resumo: ABSTRACT Background: Cholangiocarcinoma is an aggressive neoplasm that usually requires palliative biliary drainage. Photodynamic therapy (PDT) has been described as a successful adjunct treatment to malignant biliary obstruction. Aim: To describe the use of digital cholangioscope to help provide laser light during biliary PDT session using locally developed light source. Method: Patient receives intravenous photosensitizer 24 h before the procedure. It starts with a regular duodenoscopy. After identification of the major papilla and retrograde cannulation, the digital cholangioscope is introduced into the common bile duct. Then, the cholangioscopic examination helps to identify the neoplastic stricture. Under direct visualization lighting catheter is advanced through the cholangioscope. Repositioning is recommended every centimeter to cover all strictured area. At the end of the procedure, a final cholangioscopy assesses the bile duct for the immediate result and adverse events. Result: This procedure was applied in one 82-year-old male due to obstructive jaundice in the last two months. EUS and ERCP revealed a severe dilation of the common bile duct associated with choledocholithiasis. Besides, was revealed dilation of hepatic duct up to a well-circumscribed hypoechoic solid mass measuring 1.8x2 cm compressing the common hepatic duct. The mass was deemed unresectable and the patient was referred for palliative treatment with PDT. He remained asymptomatic for three months. He perished due to complications 15 months after the PDT session. Conclusion: Digital cholangioscopy-guided biliary PDT is feasible and seems safe and effective as an adjunct modality in the palliation of extrahepatic cholangiocarcinoma.

RESUMO Racional: Colangiocarcinoma é neoplasia agressiva que geralmente exige drenagem biliar paliativa. A terapia fotodinâmica (TFD) tem sido descrita como tratamento adjunto bem-sucedido para tratar obstrução biliar maligna. Objetivo: Descrever o emprego do colangioscópio digital para ajudar a fornecer luz de laser durante sessão de TFD biliar usando fonte de luz desenvolvida localmente. Método: Paciente recebe fotossensibilizador intravenoso 24 h antes do procedimento que começa com duodenoscopia regular. Após a identificação da papila principal e da canulação retrógrada, o colangioscópio digital é introduzido no ducto biliar comum. Em seguida, o exame colangioscópico ajuda a identificar a estenose neoplásica. Sob visualização direta, o cateter de iluminação avança através do colangioscópio. Reposicionamento é feito a cada centímetro. Ao final colangioscopia avalia o ducto biliar quanto ao resultado imediato e a eventos adversos. Resultado: Este procedimento foi aplicado em um homem de 82 anos devido à icterícia obstrutiva nos últimos dois meses. EUS e CPRE revelaram dilatação grave do ducto biliar comum associada à coledocolitíase. Além disso, havia dilatação do ducto hepático até massa sólida hipoecóica bem circunscrita, medindo 1,8x2 cm, comprimindo o ducto hepático comum. Ela foi considerada irressecável e paciente encaminhado para tratamento paliativo com TFD que permaneceu assintomático por três meses. Morreu devido a complicações 15 meses após a sessão de TFD. Conclusão: A TFD biliar guiada por colangioscopia digital é viável e parece segura e eficaz como modalidade auxiliar na paliação de colangiocarcinoma extra-hepático.
Descritores: Fotoquimioterapia
Neoplasias dos Ductos Biliares/tratamento farmacológico
Neoplasias dos Ductos Biliares/diagnóstico por imagem
Endoscopia do Sistema Digestório
Colangiocarcinoma/tratamento farmacológico
Colangiocarcinoma/diagnóstico por imagem
-Ductos Biliares Intra-Hepáticos
Evolução Fatal
Limites: Humanos
Masculino
Idoso de 80 Anos ou mais
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: biblio-1282553
Autor: Braz, Maria Cleide Azevedo; Saguchi, André Hayato; Akisue, Eduardo; Lira, Adriana de Oliveira; Paiva, Sidnea Aparecida Freitas; Brugnera Junior, Aldo; Macedo, Mary Caroline Skelton; Michelotto, André Luiz da Costa; Araki, Ângela Toshie.
Título: Comparative in vitro study of intracanal Enterococcus faecalis reduction using photosensitizers in aPDT
Fonte: Braz. j. oral sci;20:e214034, jan.-dez. 2021. ilus.
Idioma: en.
Resumo: Aim: To compare Enterococcus faecalis reduction after antimicrobial photodynamic therapy (aPDT) used with methylene blue, toluidine blue, tannin, and curcumin as photosensitizers, an adjunct to endodontic chemomechanical preparation (CMP) in root canals of human teeth. Methods: A total of 120 single-rooted teeth were divided into 6 groups (n = 20): G1- CMP and 2.5% sodium hypochlorite (NaOCl); G2- CMP and saline solution; G3- CMP, 2.5% NaOCl, and aPDT with 0.005% methylene blue; G4- CMP, 2.5% NaOCl, and aPDT with 0.005% toluidine blue; G5- CMP, 2.5% NaOCl, and aPDT with 0.005% tannin; and G6- CMP, 2.5% NaOCl, and aPDT with 0.005% curcumin. A portable semiconductor laser was used (660 nm, 100 mW, 1.8 J, 180s) in groups 1, 2, 3, 4, 5, and a blue LED light-curing (420-480 nm, 1200 mV/cm2 ) in G6. For all groups, a 5 min pre-irradiation time was applied. Samples were collected before (initial collection), immediately after (intermediate collection) and 7 days after CMP (final collection) for colony-forming unit (CFU) counting. The Kruskal-Wallis test and analysis of variance (ANOVA) were performed (p < 0.05; 95% confidence interval). Results: In between-group comparisons, there was no significant difference observed in the number of CFUs at the initial (p >< 0.001) and final collections (p >< 0.001) for G2 and G3. In within-group comparisons, the number of CFUs showed a decreasing trend in G4 (p = 0.007) and G5 (p = 0.001). Conclusion: Photosensitizers promoted E. faecalis reduction, with better results for tannin and curcumin. Alternative photosensitizers should be the focus of further studies.>< 0.05; 95% confidence interval). Results: In between-group comparisons, there was no significant difference observed in the number of CFUs at the initial (p < 0.001) and final collections (p >< 0.001) for G2 and G3. In within-group comparisons, the number of CFUs showed a decreasing trend in G4 (p = 0.007) and G5 (p = 0.001). Conclusion: Photosensitizers promoted E. faecalis reduction, with better results for tannin and curcumin. Alternative photosensitizers should be the focus of further studies.>< 0.001) and final collections (p < 0.001) for G2 and G3. In within-group comparisons, the number of CFUs showed a decreasing trend in G4 (p = 0.007) and G5 (p = 0.001). Conclusion: Photosensitizers promoted E. faecalis reduction, with better results for tannin and curcumin. Alternative photosensitizers should be the focus of further studies>< 0.001) for G2 and G3. In within-group comparisons, the number of CFUs showed a decreasing trend in G4 (p = 0.007) and G5 (p = 0.001). Conclusion: Photosensitizers promoted E. faecalis reduction, with better results for tannin and curcumin. Alternative photosensitizers should be the focus of further studies
Descritores: Fotoquimioterapia
Taninos
Fármacos Fotossensibilizantes
Curcumina
Endodontia
Responsável: BR218.1 - Biblioteca Carlos Henrique Robertson Liberalli


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Id: biblio-1131614
Autor: Ozek, Dilay; Karaca, Emine Esra; Kemer, Ozlem Evren.
Título: Accelerated corneal cross-linking with hypo-osmolar riboflavin in thin keratoconic corneas: 2-year follow-up / Cross-linking corneano acelerado com riboflavina hiposmolar em córneas ceratocônicas finas: 2 anos de acompanhamento
Fonte: Arq. bras. oftalmol;83(4):277-282, July-Aug. 2020. tab.
Idioma: en.
Resumo: ABSTRACT Purpose: This study was performed to evaluate the outcomes of accelerated corneal cross-linking in keratoconic corneas with thinnest pachymetry values of <400 µm. Methods: The study included 28 eyes of 24 patients. The uncorrected and best-corrected visual acuities (logMAR), flattest and steepest keratometric readings, central corneal thickness at the thinnest point, corneal higher-order aberrations, and contrast sensitivity were assessed before and at 1, 3, 6, 12, and 24 months after corneal cross-linking. Result: The mean best-corrected visual acuity and contrast sensitivity increased (p=0.02, p=0.03, respectively), whereas the mean uncorrected visual acuity did not significantly differ (p>0.05) at 24 months after corneal cross-linking, compared with measurements before corneal cross-linking. Although the mean flattest keratometric reading showed no significant change (p=0.58), the mean steepest keratometric reading was reduced when compared with its value before corneal cross-linking (p=0.001). No change was observed in the mean central corneal thickness at the thinnest point at 24 months after corneal cross-linking, compared with its value before corneal cross-linking (p=0.12). Conclusion: Accelerated corneal cross-linking in keratoconic eyes with thin corneas could halt the progression of keratoconus in corneas thinner than 400 µm at 24 months after treatment.

RESUMO Objetivo: Este estudo foi realizado para avaliar os resultados do cross-linking corneano acelerado em córneas ceratocônicas com os valores mais baixos de paquimetria <400 µm. Métodos: O estudo incluiu 28 olhos de 24 pacientes. As acuidades visuais não corrigidas e melhor corrigidas (logMAR), leituras ceratométricas mais planas e íngremes, espessura corneana central no ponto mais fino, aberrações corneanas de mais alta ordem e a sensibilidade ao contraste foram avaliadas antes e em 1, 3, 6, 12 e 24 meses após a realização do do cross-linking. Resultados: A média da acuidade visual melhor corrigida e a sensibilidade ao contraste aumentaram (p=0,02, p=0,03, respectivamente), enquanto a média da acuidade visual não corrigida não diferiu significativamente (p>0,05) aos 24 meses após o cross-linking, comparada com medidas antes do procedimento. Embora a leitura da média da ceratometria mais plana não tenha apresentado alteração significativa (p=0,58), a leitura ceratométrica mais íngreme diminuiu quando comparada ao seu valor antes do cross-linking (p=0,001). Não foi observada alteração na média da espessura corneana central no ponto mais fino aos 24 meses após o cross-linking em comparação com seu valor antes do procedimento (p=0,12). Conclusão: O cross-linking corneano acelerado nos olhos ceratocônicos com córneas finas pode interromper a progressão do ceratocone nas córneas mais finas que 400 µm 24 meses após o tratamento.
Descritores: Fotoquimioterapia
Colágeno/uso terapêutico
Córnea
Topografia da Córnea
Reagentes para Ligações Cruzadas/uso terapêutico
-Riboflavina/uso terapêutico
Raios Ultravioleta
Seguimentos
Fármacos Fotossensibilizantes/uso terapêutico
Ceratocone/tratamento farmacológico
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: biblio-1135496
Autor: Fernandes, Maria Luiza da Matta Felisberto; Maia, Caroline Andrade; Santos, Alice Machado Carvalho; Vilela, Camila Rocha; Araujo, Felipe Ribeiro; Mohallen, Maria de Lourdes; Silveira, Lívio Barros; Fernandes, Alexandre Moreira.
Título: Antimicrobial Photodynamic Therapy in the Endodontic Treatment of Deciduous Teeth: In Vivo Pilot Study
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e5309, 2020. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To evaluate the Antimicrobial Photodynamic Therapy (aPDT) in infected deciduous teeth by quantifying the viable bacteria in root canal treatment. Material and Methods: Radicular canal cultures were collected (n= 10). Four intra-canal samples were collected at four different times in each of the sampled teeth, as follows: Time 1 (T1), baseline: After opening the pulp-chamber; Time 2 (T2): After application of aPDT; Time 3 (T3): After mechanical, chemical manipulation; Time 4 (T4): After a second application of aPDT. The aPDT was performed with a 4J/cm energy low-intensity diode, together with 0.005% methylene blue as a photosensitizer. The clinical specimens were taken to the laboratory for a bacteria count (colony forming units) and the results were statistically analyzed using the Friedman and Wilcoxon tests, with a significance level of α=0.05. Results: Statistical differences were seen between the numbers of bacteria at times T1-T2, T1-T3 and T1-T4 on the cultivated plates. However, no significant statistical differences were observed between the number of bacteria in samples T2-T3, T2-T4 and T3-T4. Conclusion: Antimicrobial photodynamic therapy can be a good co-adjuvant in root canal decontamination of necrotic primary teeth.
Descritores: Fotoquimioterapia/instrumentação
Dente Decíduo
Necrose da Polpa Dentária/diagnóstico por imagem
Terapia com Luz de Baixa Intensidade/instrumentação
-Brasil/epidemiologia
Projetos Piloto
Estatísticas não Paramétricas
Dente não Vital/diagnóstico
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-1135527
Autor: Catão, Maria Helena Chaves de Vasconcelos; Batista, Ana Luzia Araújo.
Título: In Vitro Evaluation of the Antibacterial Effect of Photodynamic Therapy with Methylene Blue
Fonte: Pesqui. bras. odontopediatria clín. integr;20:e4980, 2020. tab.
Idioma: en.
Resumo: Abstract Objective: To evaluate, in vitro, the effect of photodynamic therapy (PDT) compared to laser therapy and the use of a photosensitizer alone. Material and Methods: The following therapies were used: PDT, laser therapy and photosensitizer alone. For PDT, methylene blue (MB) at different concentrations and red laser InGaAlP 660nm were used. For the use of low-power laser (LPL) alone, red laser InGaAlP 660 nm and infrared laser AsGaAl, 830 nm, both in continuous emission were used. Standard ATCC strains of Staphylococcus aureus (S. aureus), Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa) species were used. The antibacterial effect of PDT was quantified by the diameter of the inhibition halos. Results: PDT (LPL 660 nm, 320 J/cm2) with MB at concentration of 50 µg/mL showed antibacterial efficacy only when tested against S. aureus and E. coli strains, as well as with the isolated use of MB at the same concentration. Using LPL alone, whether red or infrared, with different dosimetry, no antibacterial effect was observed. In none of the therapeutic modalities used, P. aeruginosa inactivation was observed. Conclusion: Antibacterial effects of PDT (LPL 660 nm + MB 50 µg/mL) were observed for S. aureus and E. coli, as well as with the isolated use of MB (50 µg/mL). For P. aeruginosa, no antibacterial effect with any of the protocols recommended in the study was observed.
Descritores: Fotoquimioterapia/instrumentação
Técnicas In Vitro
Terapia com Luz de Baixa Intensidade/instrumentação
Azul de Metileno
Antibacterianos/imunologia
-Staphylococcus aureus
Brasil
Estatísticas não Paramétricas
Tipo de Publ: Estudo Comparativo
Estudo de Avaliação
Responsável: BR1264.1 - Biblioteca Setorial Prof Alberto M Campos


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Id: biblio-892937
Autor: Pereira, Nalisson Marques; Feitosa, Luciano Santos; Navarro, Ricardo Scarparo; Kozusny-Andreani, Dora Inés; Carvalho, Naacia Marques Pereira.
Título: Use of photodynamic inactivation for in vitro reduction of prevalent bacteria in Fournier's Gangrene
Fonte: Int. braz. j. urol;44(1):150-155, Jan.-Feb. 2018. tab, graf.
Idioma: en.
Resumo: ABSTRACT Fournier's Gangrene (FG) is an infectious disease caused by several synergic microbes, with high morbidity and mortality rates; therefore, the search for new less invasive and mutilating treatments, with faster recovery, has been proposed. Surgical intervention, the use of several systemic and topic antibiotics, and hyperbaric oxygen therapy are currently the best approach for the treatment of these patients. The use of Photodynamic Inactivation (PDI) aims to lower morbidity and mortality, by reducing bacterial microbiota and speeding wound healing. In the present study, viable bacteria were separated in four groups: Group L-/F- (no irradiation with red laser and absence of methylene blue photosensitizer), Group L-/F+ (no irradiation with red laser and presence of methylene blue), Group L+/F- (irradiation with red laser and absence of methylene blue) and L+/F+ (irradiation with red laser associated to methylene blue). In all groups, exposure time to treatment was 5, 10 and 15 minutes. The concentration of methylene blue photosensitizer was 0.1mg/L, and the dose of red laser (660nm wave length) was 176.9mW/cm2. Following irradiation, the reduction of number of bacteria was evaluated, and the results were expressed in colony forming units (CFU) and as exponential reduction. As the main results, in the L+/F+ group, there were no Clostridium perfringens and Staphylococcus aureus CFUs and there was a reduction of Escherichia coli that was not observed in the other groups.
Descritores: Fotoquimioterapia
Fármacos Fotossensibilizantes/uso terapêutico
Gangrena de Fournier/microbiologia
Gangrena de Fournier/terapia
Azul de Metileno/uso terapêutico
-Staphylococcus aureus/isolamento & purificação
Técnicas In Vitro
Clostridium perfringens/isolamento & purificação
Escherichia coli/isolamento & purificação
Responsável: BR1.1 - BIREME


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Id: biblio-994591
Autor: Peru. Instituto de Evaluación de Tecnologías en Salud e Investigación.
Título: Guía de práctica clínica para el diagnóstico y tratamiento de la degeneración macular relacionada a la edad: guía en versión extensa / Clinical practice guideline for the diagnosis and treatment of age-related macular degeneration: long version guide.
Fonte: Lima; Seguro Social de Salud (EsSalud); 2019. [1-72] p.
Idioma: es.
Resumo: Brindar recomendaciones y puntos de buenas prácticas clínicas basadas en evidencia para el adecuado diagnóstico y tratamiento de los pacientes con degenaración macular relacionada con la edad (DMRE), contestando a las siguientes preguntas: a) En personas mayores de 50 años, ¿cómo se debería diagnosticar y clasificar la DMRE? b) En personas con DMRE, ¿qué intervenciones deben usarse para prevenir la progresión de la enfermedad? c) En personas con DMRE exudativa, ¿se debería utilizar antiangiogénicos para el tratamiento de la enfermedad? d) En personas con DMRE exudativa, ¿se debería utilizar la terapia fotodinámica como tratamiento adyuvante? e) En personas con DMRE exudativa, ¿se debería utilizar corticoides intravítreos como tratamiento adyuvante? f) En personas con DMRE, ¿cuál es la mejor estrategia de seguimiento de la enfermedad?
Descritores: Degeneração Macular Exsudativa/tratamento farmacológico
Degeneração Macular/classificação
Degeneração Macular/diagnóstico
Degeneração Macular/tratamento farmacológico
-Fotoquimioterapia
Corticosteroides/uso terapêutico
Inibidores da Angiogênese/uso terapêutico
Degeneração Macular Exsudativa/prevenção & controle
Degeneração Macular Exsudativa/terapia
Degeneração Macular/terapia
Limites: Humanos
Idoso
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: biblio-950729
Autor: Matei, Clara; Tampa, Mircea; Caruntu, Constantin; Ion, Rodica-Mariana; Georgescu, Simona-Roxana; Dumitrascu, Georgiana Roxana; Constantin, Carolina; Neagu, Monica.
Título: Protein microarray for complex apoptosis monitoring of dysplastic oral keratinocytes in experimental photodynamic therapy
Fonte: Biol. Res;47:1-9, 2014. ilus, graf.
Idioma: en.
Projeto: Research Projects.
Resumo: BACKGROUND: Photodynamic therapy is an alternative treatment of muco-cutaneous tumors that uses a light source able to photoactivate a chemical compound that acts as a photosensitizer. The phthalocyanines append to a wide chemical class that encompasses a large range of compounds; out of them aluminium-substituted disulphonated phthalocyanine possesses a good photosensitizing potential. RESULTS: The destructive effects of PDT with aluminium-substituted disulphonated phthalocyanine are achieved by induction of apoptosis in tumoral cells as assessed by flow cytometry analysis. Using protein microarray we evaluate the possible molecular pathways by which photodynamic therapy activates apoptosis in dysplastic oral keratinocytes cells, leading to the tumoral cells destruction. Among assessed analytes, Bcl-2, P70S6K kinase, Raf-1 and Bad proteins represent the apoptosis related biomolecules that showed expression variations with the greatest amplitude. CONCLUSIONS: Up to date, the intimate molecular apoptotic mechanisms activated by photodynamic therapy with this type of phthalocyanine in dysplastic human oral keratinocytes are not completely elucidated. With protein microarray as high-throughput proteomic approach a better understanding of the manner in which photodynamic therapy leads to tumoral cell destruction can be obtained, by depicting apoptotic molecules that can be potentially triggered in future anti-tumoral therapies.
Descritores: Fotoquimioterapia
Lesões Pré-Cancerosas/tratamento farmacológico
Neoplasias Bucais/tratamento farmacológico
Queratinócitos/efeitos dos fármacos
Apoptose/efeitos dos fármacos
Análise Serial de Proteínas
-Compostos Organometálicos/uso terapêutico
Lesões Pré-Cancerosas/patologia
Radiossensibilizantes/uso terapêutico
Neoplasias Bucais/patologia
Queratinócitos/patologia
Proteínas Proto-Oncogênicas c-bcl-2/análise
Proteínas Proto-Oncogênicas c-raf/análise
Proteínas Quinases S6 Ribossômicas 70-kDa/análise
Linhagem Celular Tumoral
Proteína de Morte Celular Associada a bcl/análise
Citometria de Fluxo
Indóis/uso terapêutico
Limites: Humanos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Chile
Texto completo
Id: biblio-1056495
Autor: Guiñez-Coelho, Marcial; Letelier-Sepúlveda, Gabriela.
Título: Especificidad y Sensibilidad de Sistema ICDAS TM versus Índice COPD en la Detección de Caries / Specificity and Sensitivity of the ICDAS TM System versus the DMFT Index in Caries Detection
Fonte: Int. j. odontostomatol. (Print);14(1):12-18, mar. 2020. tab, graf.
Idioma: es.
Resumo: RESUMEN: La caries dental no tratada es la enfermedad crónica más frecuente en adultos y la caries no tratada en dientes temporales es la décima enfermedad crónica más frecuente. En Chile los adultos presentan un COPD promedio entre 3,76 - 22,16, pero los estudios no son en población representativa y no existen estudios comparativos entre ceod/ COPD e ICDASTM. A nivel mundial, su prevalencia puede alcanzar el 100 % de la población estudiada. Se buscará evaluar si existen diferencias en la sensibilidad y especificidad en la detección de caries utilizando ICDASTM y ceod/COPD. Se realizó una revisión sistemática cualitativa realizando una búsqueda sobre los índices de caries ceod/COPD y sistema ICDASTM, tanto en Chile como a nivel mundial, en las bases de datos Medline, ClinicalKey y SciELO encontrando 3.581, de ellos, 21 se leyeron por completo y 14 cumplieron nuestros criterios. La sensibilidad y especificidad es mayor con ICDASTM que con el índice ceod/COPD y entrega hasta un 43 % más información al detectar lesiones no cavitadas, pero necesita de mayor tiempo para su realización y más recursos al utilizar luz, aire comprimido y una profilaxis previa al examen. Capacitaciones previas, conocimientos y experiencia en ICDASTM son fundamentales para el mejor resultado, estudios demostraron que mientras mayor experiencia, la sensibilidad y especificidad aumentaba a diferencia del índice ceod/COPD. Se deben realizar más estudios comparativos entre ambos índices e incluir ICDASTM en niños por su capacidad de detectar lesiones no cavitadas las cuales son las más prevalentes en dientes temporales.

ABSTRACT: Untreated dental caries is the most frequent chronic disease in adults and untreated caries in primary teeth is the tenth most frequent chronic disease. In Chile, adults have an average DMFT between 3.76-22.16, but the studies are not in a representative population and there are no comparative studies between dmft/DMFT and ICDASTM. Worldwide, its prevalence can reach 100 % of the population studied. The objective of the study was to evaluate if there are differences in the sensitivity and specificity in the detection of caries using ICDASTM and dmft/DMFT. A qualitative systematic review was done, carrying out a search on the dmft/DMFT index and the ICDASTM system, both in Chile and worldwide, in the Medline, ClinicalKey and SciELO databases, finding 3,581, of which, 21 were read completely and 14 met the inclusion and exclusion criteria. The sensitivity and specificity is greater with ICDASTM than with the dmft/DMFT index and delivers up to 43 % more information when detecting non-cavitated lesions, but it needs more time for its realization and more resources because it needs to use light, compressed air and prophylaxis before the examination. Previous training, knowledge and experience in ICDASTM are fundamental for the best results. Studies showed that the greater the experience, the sensitivity and specificity increased, unlike the dmft/DMFT index. More comparative studies should be conducted between both indexes and include ICDASTM in children for their ability to detect non-cavitated lesions, which are the most prevalent in temporary teeth.
Descritores: Fotoquimioterapia/métodos
Índice CPO
Cárie Dentária/diagnóstico por imagem
-Fatores de Tempo
Fármacos Fotossensibilizantes
Suscetibilidade à Cárie Dentária
Limites: Humanos
Masculino
Feminino
Pré-Escolar
Criança
Adolescente
Adulto
Pessoa de Meia-Idade
Tipo de Publ: Revisão Sistemática
Responsável: CL1.1 - Biblioteca Central


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Fotocópia
Consolaro, Alberto
Silva, Léa Assed Bezerra da
Texto completo
Id: biblio-1178040
Autor: Silva, Raquel Assed Bezerra da; Oliveira, Daniela Silva Barroso de; Oliveira, Katharina Morant Holanda de; Pucinelli, Carolina Maschietto; Nelson Filho, Paulo; Consolaro, Alberto; Novaes Jr, Arthur Belém; Silva, Lea Assed Bezerra da.
Título: Photosensitizers and exposure times to light showed tissue compatibility in isogenic mice / Fotossensibilizadores e tempo de exposição a luz em relação a compatibilidade de tecidos em ratos isogênicos
Fonte: Braz. dent. sci;24(2):1-12, 2021. tab, ilus.
Idioma: en.
Resumo: Objective: The aim of this study was to evaluate the subcutaneous tissue response after different protocols to photodynamic therapy (PDT). In Phase 1, were tested the diode laser (used for 1min) associated to the photosensitizer phenothiazine chloride solution (PCS) in different concentrations. In Phase 2 ­ the diode laser and LED were tested associated to two different photosensitizers, PCS and Curcumin, in different exposure times of light application. Material and Methods: After 7, 21 and 63-days the animals were euthanized and the subcutaneous tissue processed to histological analysis. Qualitative and semi-quantitative descriptions of the inflammatory process and immunohistochemical technique were performed. The obtained data were analyzed by Kruskal-Wallis and Dunn's post-test (α= 0.5). Results: On Phase 1, the tissue response was very similar among the groups. For the inflammatory infiltrate, PCS with concentration of 10mg/mL exhibited the most intense reaction (p > 0.05). On Phase 2, at 7-days period, the analyzed parameters presented small magnitude and after 21 and 63-days, all the parameters demonstrated tissue compatibility. Conclusion: Both photosensitizers presented proper tissue compatibility regardless the different concentrations used on Phase 1 and different durations of light exposure on Phase 2 (AU)

Objetivo: Este estudo avaliou a resposta do tecido subcutâneo após terapia fotodinâmica, utilizando na Fase 1 - laser diodo por 1min e solução fotossensibilizadora de cloreto de fenotiazina (CF) em diferentes concentrações e Fase 2 - laser diodo e LED e dois fotossensibilizadores, CF e Curcumina, em diferentes tempos de exposição da aplicação de luz. Material e Métodos: Após 7, 21 e 63 dias, foram realizadas descrições qualitativas e semiquantitativas do processo inflamatório e técnica de imunoistoquímica. Os dados foram analisados pelo pós-teste de Kruskal-Wallis e Dunn (α = 0,5). Resultados: Na Fase 1, a resposta do tecido foi muito semelhante. O infiltrado inflamatório, na concentração de 10 mg / mL, exibiu reação mais intensa (p > 0,05). Na Fase 2, aos 7 dias, os parâmetros analisados apresentaram pequena magnitude. Aos 21 e 63 dias, todos os parâmetros demonstraram compatibilidade com o tecido. Conclusão: Ambos os fotossensibilizadores apresentaram compatibilidade de tecido adequada, independentemente das diferentes concentrações utilizadas na Fase 1 e diferentes durações de exposição à luz na Fase 2 (AU)
Descritores: Fotoquimioterapia
Ratos Endogâmicos
Curcumina
Tela Subcutânea
Limites: Animais
Camundongos
Tipo de Publ: Estudo Comparativo
Responsável: BR243.1 - Serviço Técnico de Biblioteca e Documentação



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