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Texto completo SciELO Saúde Pública
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Id: lil-733149
Autor: Gomes, Renata Machado dos Santos; Oliveira, Valdir de Castro.
Título: International cooperation Brazil-Cuba-Haiti: the role of community radios in strengthening social mobilization in the public health context in Haiti / Cooperação internacional Brasil-Cuba-Haiti: o papel das rádios comunitárias no fortalecimento da mobilização social no âmbito da saúde pública no Haiti
Fonte: Ciênc. saúde coletiva;20(1):199-208, 01/2015.
Idioma: en.
Resumo: The present article investigates the role of Haitian community radios in strengthening social mobilization, with the aim of supporting the actions undertaken in the field of public health in Haiti, based on the development of the Workshop for community radios, as part of the Tripartite Cooperation Brazil-Cuba-Haiti. The qualitative methodology is justified because of the study content, an analysis of documents and direct observation, through a case study presented at the Workshop held in the department of Hinches, in Haiti. This meeting was held in the context of the Working Group on Tripartite Communication, under the responsibility of the Health Channel/Fiocruz, in partnership with the Department for Health Promotion and Environmental Prevention of the Ministry of Health and Population of Haiti (DPSPE/MSPP/Haiti), with a proposal to better structure a network of multipliers in health promotion.

O presente artigo investiga o papel das rádios comunitárias haitianas no fortalecimento da mobilização social com a finalidade de subsidiar as ações empreendidas no campo da saúde pública no Haiti a partir da construção e do desenvolvimento da Oficina para rádios comunitárias, no âmbito da Cooperação Tripartite Brasil-Cuba-Haiti. A metodologia de cunho qualitativo justifica-se pelo teor do estudo, de análise de documentos e da observação direta, mediante estudo de caso a partir da Oficina, realizada no departamento de Hinches, no Haiti. O encontro foi realizado no âmbito do Grupo de Trabalho de Comunicação da Tripartite, sob a responsabilidade do Canal Saúde/Fiocruz, em parceria com o Departamento de Promoção da Saúde e Prevenção do Meio Ambiente do Ministério da Saúde e População do Haiti (DPSPE/MSPP/Haiti), com a proposta de estruturar uma rede de multiplicadores de promoção da saúde.
Descritores: Antioxidantes/farmacologia
Fígado/patologia
Ácidos Fosfóricos/farmacologia
Compostos de Tungstênio/farmacologia
-Doença Aguda
Administração Oral
Tetracloreto de Carbono
Modelos Animais de Doenças
Glutationa/metabolismo
Testes de Função Hepática
Fígado/efeitos dos fármacos
Necrose/induzido quimicamente
Necrose/tratamento farmacológico
Necrose/fisiopatologia
Estresse Oxidativo/efeitos dos fármacos
Ratos Wistar
Tioacetamida
Limites: Animais
Feminino
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-1001588
Autor: Shah, Rehmat; Subhan, Fazal; Sultan, Syed Muhammad; Ali, Gowhar.
Título: Short-term oral administration of risperidone induces pancreatic damage and hyperamylasemia in Sprague-dawley rats
Fonte: Braz. J. Pharm. Sci. (Online);54(4):e17841, 2018. graf.
Idioma: en.
Resumo: Risperidone is an atypical antipsychotic acting mainly as a dopamine D2 and serotonin 5-HT2 receptors antagonist prescribed in the treatment of schizophrenia and various affective disorders. Risperidone has been reported to be associated with weight gain, panreatitis and type 2 diabetes mellitus. Various mechanisms of risperidone-induced toxicities have been reported but the histology of tissues especially pancreas has never been studied. Therefore, the current study was designed to elucidate the toxic effects of chronic administration of risperidone on pancreas, liver and kidneys. Animals (rats) of either gender were divided into two groups, the risperidone and control groups. Risperidone was administered in a dose of 2.5 mg/kg/d for three weeks. The controls received acidified saline only. Both the groups received restricted diet (20 g/12 h). The body weight and level of random blood sugar (RBS) were measured on a weekly basis. The levels of lipase and amylase were determined at the conclusion of the experiment. At the end of the experiment, the tissues were dissected out for histopathological evaluation. Risperidone showed no weight gain, hyperglycemia or rise in the level of lipase (P> 0.05); however, the level of amylase was raised (***P<0.05). Histological examination under light microscope showed no hepatotoxicity, nephrotoxicity but did show damage to the pancreas. The findings of this study indicated that the incidence of adverse effects associated with risperidone could be prevented/alleviated/delayed by allowing restricted diet.
Descritores: Pâncreas/efeitos dos fármacos
Administração Oral
Risperidona/efeitos adversos
-Antipsicóticos
Antagonistas dos Receptores de Dopamina D2
Limites: Animais
Masculino
Feminino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-951930
Autor: Haseeb, Muhammad Tahir; Bashir, Sajid; Hussain, Muhammad Ajaz; Ashraf, Muhammad Umer; Erum, Alia; Naeem-ul-Hassan, Muhammad.
Título: Acute toxicity study of a polysaccharide based hydrogel from linseed for potential use in drug delivery system
Fonte: Braz. J. Pharm. Sci. (Online);54(2):e17459, 2018. tab.
Idioma: en.
Resumo: ABSTRACT Linseed hydrogel (LSH) was evaluated by acute toxicity for its potential application in oral drug delivery design. White albino mice and rabbits were divided in four groups (I-IV) and different doses of LSH (1, 2 and 5 g/kg body weight) were given except to the control group (I) that was left untreated. Rabbits were monitored for eye irritation, acute dermal toxicity and primary dermal irritation, whereas, body weight, food and water consumption, hematology and clinical biochemistry, gross necropsy and histopathology of vital organs were scrutinized in mice. LSH was considered safe after eye irritation test as no adverse signs or symptoms were seen in the eye. In dermal toxicity and irritation study, skin of treated rabbits was found normal in color without any edema or erythema. After oral administration, there was no sign of any abnormalities in treated group animals (II-IV). The hematology and clinical biochemistry of treated group animals was comparable with the control group. Histopathology of vital organs has not shown any lesion or abnormalities. In the light of these outcomes, it can be concluded that LSH is not a hazardous biomaterial and could be incorporated as an excipient in oral and dermal preparations.
Descritores: Polissacarídeos
Linho/classificação
Hidrogel de Polietilenoglicol-Dimetacrilato/análise
Liberação Controlada de Fármacos
-Administração Oral
Testes de Toxicidade Aguda/métodos
Hematologia
Limites: Animais
Masculino
Feminino
Coelhos
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-951908
Autor: Rahman, Mohammad Akhlaquer; Mujahid, Mohammad.
Título: Development of self-nanoemulsifying tablet (SNET) for bioavailability enhancement of sertraline
Fonte: Braz. J. Pharm. Sci. (Online);54(1):e17232, 2018. tab, graf.
Idioma: en.
Resumo: The purpose of the study was to combine the advantages of self-nanoemulsifying drug delivery systems and tablets as a conventional dosage form. Self-nanoemulsifying drug delivery system (SNEDDS) was prepared to enhance the solubility and thus oral bioavailability of sertraline. Aqueous titration method was used to prepare the liquid SNEDDS; ternary phase diagrams were constructed and based on smaller droplet size (24.8 nm), minimum viscosity (153.63 cP) and polydispersity index (0.182), higher percentage transmittance (95%) and in vitro drug release (97%), an optimum system was designated. Liquid SNEDDS was transformed into free-flowing powder by solid adsorption technique followed by compression into tablets. In vitro release of sertraline from liquid and solid SNEDDS was found to be highly significant compared to plain sertraline (p<0.01). Pharmacokinetic studies after oral administration of liquid and solid SNEDDS in rats showed about 6-and 5-fold increased absorption of sertraline compared to the aqueous suspension of sertraline. These studies demonstrate that the solid SNEDDS are promising strategies for successful delivery of poorly water-soluble drug like sertraline
Descritores: Comprimidos/análise
Disponibilidade Biológica
Sertralina/farmacologia
-Solubilidade
Administração Oral
Emulsificantes
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Simöes, Cláudia Maria Oliveira
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Id: biblio-839460
Autor: Cárdenas, Paola Andrea; Kratz, Jadel Müller; Hernández, Aura; Costa, Geison Modesti; Ospina, Luis Fernando; Baena, Yolima; Simões, Cláudia Maria Oliveira; Jimenez-Kairuz, Álvaro; Aragon, Marcela.
Título: In vitro intestinal permeability studies, pharmacokinetics and tissue distribution of 6-methylcoumarin after oral and intraperitoneal administration in Wistar rats
Fonte: Braz. J. Pharm. Sci. (Online);53(1):e16081, 2017. tab, graf.
Idioma: en.
Projeto: CAPES.
Resumo: ABSTRACT 6-Methylcoumarin (6MC) is a semisynthetic coumarin with important in vitro and in vivo anti-inflammatory activity. In order to continue the pre-clinical characterization of this molecule, in vitro intestinal permeability, plasma profile and tissue distribution after oral administration in rats were studied. The permeability of 6MC was evaluated by the Caco-2 cellular model in both the apical-basal (A-B) and basal-apical (B-A) directions. The pharmacokinetics and biodistribution were evaluated in rats after oral and intraperitoneal administration at doses of 200 mg/kg. Transport experiments with Caco-2 cells showed that 6MC presented high permeability at all concentrations evaluated. This finding suggested that 6MC could be transported across the gut wall by passive diffusion. The plasma concentration-time curve showed that the maximum concentration (Cmax) was 17.13 ± 2.90 µg/mL at maximum time (Tmax) of 30 min for the oral route and Cmax 26.18 ± 2.47 µg/mL at 6.0 min for the intraperitoneal administration, with elimination constant of (Ke ) 0.0070 min-1 and a short life half time of (T1/2 ) lower that 120 min. The distribution study showed that 6MC has high accumulation in the liver, and widespread distribution in all the organs evaluated.
Descritores: Permeabilidade
Técnicas In Vitro/instrumentação
Administração Oral
Ratos Wistar/classificação
Cumarínicos/análise
-Farmacocinética
Absorção Peritoneal
Enteropatias/classificação
Limites: Animais
Masculino
Feminino
Ratos
Tipo de Publ: Técnicas In Vitro
Responsável: BR1.1 - BIREME


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Id: biblio-839456
Autor: Ren, Yachao; Jiang, Lei; Yang, Shuman; Gao, Sainan; Yu, Hui; Hu, Jie; Hu, Dandan; Mao, Wenbin; Peng, Haisheng; Zhou, Yulong.
Título: Design and preparation of a novel colon-targeted tablet of hydrocortisone
Fonte: Braz. J. Pharm. Sci. (Online);53(1):e15009, 2017. tab, graf.
Idioma: en.
Projeto: Wu Liande Fund for the Youth of Harbin Medical University; . Harbin Medical University Scientific Research Innovation Fund.
Resumo: ABSTRACT The objective of this research was to design a new colon-targeted drug delivery system based on chitosan. The properties of the films were studied to obtain useful information about the possible applications of composite films. The composite films were used in a bilayer system to investigate their feasibility as coating materials. Tensile strength, swelling degree, solubility, biodegradation degree, Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC), Scanning Electron Microscope (SEM) investigations showed that the composite film was formed when chitosan and gelatin were reacted jointly. The results showed that a 6:4 blend ratio was the optimal chitosan/gelatin blend ratio. In vitro drug release results indicated that the Eudragit- and chitosan/gelatin-bilayer coating system prevented drug release in simulated intestinal fluid (SIF) and simulated gastric fluid (SGF). However, the drug release from a bilayer-coated tablet in SCF increased over time, and the drug was almost completely released after 24h. Overall, colon-targeted drug delivery was achieved by using a chitosan/gelatin complex film and a multilayer coating system.
Descritores: Comprimidos/farmacocinética
Hidrocortisona/análise
Colo/anormalidades
Quitosana/farmacologia
-Administração Oral
Gelatina/farmacologia
Tipo de Publ: Ensaio Clínico
Responsável: BR1.1 - BIREME


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Id: biblio-1011647
Autor: Upadhyay, Prabhat; Shukla, Rashmi; Tiwari, Kavindra Nath; Dubey, G P; Mishra, Sunil Kumar.
Título: Toxicity assessment of the alcoholic leaves extract of Reinwardtia indica
Fonte: Braz. j. pharm. sci;55:e18224, 2019. tab, graf, ilus.
Idioma: en.
Resumo: The present study aimed to evaluate the safety of the alcoholic leaves extract of Reinwardtia indica in Charles foster rats through an acute and sub-acute oral administration.For assessment of acute oral toxicity test, ratswere orally treated with single dose of the alcoholic leaves extract of Reinwardtia indica at the doses of 50, 250, 500, 1000 2000 and 5000 mg/kg. In sub-acute toxicity study, using the OECD guidelines no. 407, the extract was administered at the doses of 50, 250, 500, 1000, 2000 mg/kg/day for 28 consecutive days and at the dose of 2000 mg/kg satellite group also used for 6 weeks.In acute toxicity above mentioned doses neither showed mortality nor exterior signs of toxicity. In sub-acute, study no significant changes found in haematological and biochemical level ofthe treated rat after 14 days and 28 days in comparison to control. The histopathology of rat brain, kidney, liver, and heart also showed the no cellular changes after extract treated rat.The alcoholic leaves extract of Reinwardtia indica was found non-toxic in single drug dose administration up to 5000 mg/kg (acute study) and in sub-acute administration up to 2000 mg/kg.
Descritores: Extratos Vegetais/análise
Folhas de Planta/efeitos adversos
Linaceae/classificação
-Administração Oral
Testes de Toxicidade/instrumentação
Testes Hematológicos/instrumentação
Limites: Animais
Feminino
Ratos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Texto completo SciELO Chile
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Id: biblio-899594
Autor: Berkovits, Alejandro; Mezzano, Diego.
Título: Nuevos anticoagulantes orales: actualización / New oral anticoagulants: a review
Fonte: Rev. chil. cardiol;36(3):254-263, dic. 2017. tab, ilus.
Idioma: es.
Projeto: FONDECYT.
Resumo: Resumen: Los anticoagulantes orales clásicos del tipo cumarinas han estado disponibles para uso clínico por más de medio siglo. Tienen gran eficacia para tratar o prevenir trombosis y tromboembolias, y son drogas cuyo uso ha aumentado con el mejor conocimiento clínico, el aumento de los factores de riesgo y el envejecimiento de la población. Entre sus desventajas se incluyen la alta variabilidad de su efecto en cada sujeto y entre individuos, la influencia del nivel de ingesta de vitamina K, la necesidad de control periódico del nivel de anticoagulación, su interacción con múltiples drogas. Si bien, el rango terapéutico está estandarizado, es estrecho, haciendo que el tiempo en rango terapéutico sea de ≈ 60%. Por estas limitaciones, se han creado nuevos anticoagulantes orales (NACOs), siendo progresivamente aprobados para uso clínico por agencias internacionales. Genéricamente, son de 2 tipos: inhibidores selectivos de trombina (dabigatrán) o de FXa (rivaroxabán, apixabán, edoxabán y betrixabán). Los NACOs se caracterizan por su dosificación una o dos veces al día, rapidez de acción, corta vida media en la circulación, predictibilidad de su efecto, dosis preestablecidas, sin necesidad de control periódico y con escasa o nula interacción con otras drogas. Estas ventajas no se han traducido en la mayoría de los ensayos en un superior efecto antitrombótico o menor riesgo de sangrado, y en su mayoría (salvo dabigatrán) carecen de antídoto específico demostrado.

Abstracts: Vitamin K inhibitors, coumarins, have been used for more than 50 years with no dispute by other drugs. Coumarins have demonstrated great efficacy in the treatment and prophylaxis of thrombotic and thromboembolic disorders, and their use has increased progressively with the advance of clinical knowledge as well as the increase of risk factors and aging of the population. Limitations of coumarins include great variability intra and inter-individuals, the influence of foods rich in vitamin K, the need for periodical assessment of the anticoagulant level and drug interactions. The therapeutic range is standardized using the INR (International Normalized Ratio). However, the therapeutic window is narrow, with frequent periods of either over or under-dosing, with the concomitant increase of bleeding and thrombotic risks, respectively. Long-term accredited anticoagulant clinics and clinical trials report that, at best, only ≈60% of time in treatment the patients are within the therapeutic range. These limitations have created the need for new oral anticoagulants (NOACs), and several of them have been approved for clinical use by international agencies after exhaustive and specific clinical trials. Generically, NACOs are belong in two types: selective inhibitors of thrombin (dabigatran) or FXa (rivaroxaban, apixaban, edoxaban and betrixaban). NOACs are prescribed once or twice daily, the onset of action is very fast, have a low T1/2 in the circulation, their effects are highly predictable, doses are pre-established, do not need laboratory control and have a low rate of interaction with other drugs. Despite these advantages most clinical trials have shown NOACs to be not inferior with respect to coumarin. However, NOACs have no clear advantages over warfarin in antithrombotic effect or bleeding reduction. Furthermore, most of them (except dabigatran) have no specific antidotes yet.
Descritores: Antitrombinas/administração & dosagem
Inibidores do Fator Xa/administração & dosagem
Anticoagulantes/administração & dosagem
-Antitrombinas/uso terapêutico
Administração Oral
Inibidores do Fator Xa/uso terapêutico
Anticoagulantes/uso terapêutico
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.


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Id: biblio-1007454
Autor: Mena, Licet; Sierra, Roxana; Valle, Maikel; Molina, Vivian; Rodriguez, Sandra; Merino, Nelson; Zamora, Zullyt; González, Victor; Medina, Jose Alberto.
Título: Acrocomia crispa fruits lipid extract prevents LPS-induced acute lung injury in mice / Extracto lipídico de los frutos de Acrocomia crispa previene el daño pulmonar agudo inducido por LPS en ratones
Fonte: Bol. latinoam. Caribe plantas med. aromát;18(1):16-26, ene. 2019. ilus, tab.
Idioma: en.
Resumo: The aim of this study was to evaluate the effects of single oral doses of D-005 (a lipid extract obtained from the fruit oil of Acrocomia crispa) on LPS-induced acute lung injury (ALI) in mice. D-005 batch composition was: lauric (35.8%), oleic (28.4%), myristic (14.2%), palmitic (8.9%), stearic (3.3%), capric (1.9%), caprylic (1.2%), and palmitoleic (0.05%) acids, for a total content of fatty acids of 93.7%. D-005 (200 mg/kg) significantly reduced lung edema (LE) (≈ 28% inhibition) and Lung Weight/Body Weight ratio (LW/BW) (75.8% inhibition). D-005 (25, 50, 100 and 200 mg/kg) produced a significant reduction of Histological score (59.9, 56.1, 53.5 and 73.3% inhibition, respectively). Dexamethasone, as the reference drug, was effective in this experimental model. In conclusion, pretreatment with single oral doses of D-005 significantly prevented the LPS-induced ALI in mice.

El objetivo de este estudio fue evaluar los efectos de dosis orales únicas de D-005 (extracto lipídico obtenido del aceite de frutos de Acrocomia crispa) sobre el daño pulmonar agudo (DPA) inducido por LPS en ratones. La composición del lote de D-005 fue: ácido láurico (35.8%), oleico (28.4%), mirístico (14.2%), palmítico (8.9%), esteárico (3.3%), cáprico (1.9%), caprílico (1.2%) y palmitoleico (0.05%), con un contenido total de ácidos grasos de 93.7%. D-005 (200 mg/kg) redujo significativamente el edema pulmonar (EP) (≈ 28% de inhibición) y la relación peso pulmón/peso corporal (PP/PC) (75.8% de inhibición). D-005 (25, 50, 100 y 200 mg/kg) produjo una reducción significativa de la puntuación histológica (59.9, 56.1, 53.5 y 73.3% de inhibición, respectivamente). La dexametasona, fármaco de referencia, fue efectiva en este modelo experimental. En conclusión, el pretratamiento con dosis orales únicas de D-005 previno significativamente el DPA inducido por LPS en ratones.
Descritores: Extratos Vegetais/administração & dosagem
Arecaceae
Lesão Pulmonar Aguda/prevenção & controle
-Extratos Vegetais/química
Lipopolissacarídeos/efeitos adversos
Administração Oral
Cromatografia Gasosa
Lesão Pulmonar Aguda/induzido quimicamente
Ácidos Graxos/análise
Frutas
Pulmão/efeitos dos fármacos
Limites: Animais
Camundongos
Responsável: CL1.1 - Biblioteca Central


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Texto completo
Id: lil-796801
Autor: Arce, Carlos; Mir, Ian; Maqueira, Piero; Solari, Bruno; Labbé, Javier.
Título: Tratamiento anticoagulante oral en pacientes sometidos a remplazo valvular en un hospital general de Antofagasta, Chile / Oral anticoagulant treatment (OAT) in patients with cardiac valve replacement at a general hospital in Antofagasta, Chile
Fonte: Rev. chil. cardiol;35(2):147-151, 2016. graf, tab.
Idioma: es.
Resumo: Introduccion: La atención de pacientes con reemplazo valvular cardíaco constituye una actividad importante en cardiología. Si bien el recambio valvular representa una alternativa terapéutica eficaz para el manejo de esta patología, muchos pacientes requieren de tratamiento anticoagulante oral (TACO) para lograr mayor sobrevida. Objetivos: Describir los resultados terapéuticos obtenidos en un cohorte de pacientes sometidos a recambio valvular, controlados en el Hospital Regional de Antofagasta. Resultados: Se identificaron 180 pacientes con reemplazo valvular de los cuales 135 cumplieron criterios de inclusión. Hubo 76 mujeres (56,3%), 59 hombres (43,7%); la edad global promedio fue 62 años (28-90), 59 años (30-90) en las mujeres y 64 (36-81) en los hombres. La válvula intervenida fue la aórtica en 69 pacientes (51,1%), mitral en 60 (44,5%), aórtica y mitral en 5 (3,7%), y tricúspide en 1 paciente (0,7%). No hubo casos de recambio valvular pulmonar. Se instalaron 122 válvulas mecánicas (90,4%) y 13 válvulas biológicas (9,6%). El INR promedio fue 2,64 (1,11-5,47). Según válvula intervenida el INR promedio fue: mitral 2,50 (1,11-4,89), aórtica: 2,75 (1,19-5,47), mitral y aórtica: 2,65 (1,28-3,74), y tricúspide: 1,87. Del total de cirugías valvulares, 77 (57,03%) se encontraron dentro del rango terapéutico deseado: (mitral 33/60, Aórtica 43/69 mitral y aórtica 0/5, Tricúspide: 0/1). 58 pacientes (42,97%) se encontraron fuera del rango terapéutico deseado. Conclusion: Los resultados obtenidos en nuestro centro se encuentran por debajo de las recomendaciones nacionales. La dificultad por obtener mejores resultados refuerza el uso de prótesis biológicas y la implementación óptima de un policlínico de tratamiento anticoagulante (TACO).

Background: Care of patients with cardiac valve replacement often includes the need for anticoagulation which prevents complications that may decrease survival rate. Aim: to describe the experience with OAT in a cohort of patients with cardiac valve replacement at the Regional Hospital in Antofagasta Results: 135 out of 180 patients fulfilled inclusion criteria. There were 76 females (56.3%) and 59 males (43.7%), with a mean of 62 years old (28-90), 59 (30-90) in females and 64 (36-81) in males. The valve replaced was the aortic in 69 patients (51.1%), the mitral in 60 (44.5%), both the aortic and the mitral valve in 5 (3.7%). Only 1 patients had a tricuspid valve replaced. 122 mechanical valves (90.4%) and 13 biological valves (9.6%) were implanted. The overall mean INR was 2.64 (1.11 - 5.47). The mean INR value according to the valve replaced was: mitral valve 2.5 (1,11-4,89), aortic valve 2.75 (1.195.47) and mitral plus aortic valve 2.65 (1.28-3.74). Overall, 58 patients were found to be outside the therapeutic target. Conclusion: These results are less satisfactory than those proposed by national guidelines. The anticoagulant clinic must be optimized and more biological rather than mechanical valves should be used for cardiac valve replacement.
Descritores: Próteses Valvulares Cardíacas
Implante de Prótese de Valva Cardíaca/métodos
Valvas Cardíacas/cirurgia
Anticoagulantes/administração & dosagem
-Complicações Pós-Operatórias/prevenção & controle
Tromboembolia/prevenção & controle
Administração Oral
Estudos Retrospectivos
Resultado do Tratamento
Coeficiente Internacional Normatizado
Estudo Observacional
Hemorragia/induzido quimicamente
Anticoagulantes/efeitos adversos
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: CL126.2 - Biblioteca Médica Dr. Profesor Hernán Alessandri R.



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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde