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Texto completo SciELO Brasil
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Id: lil-777370
Autor: Queiroz, Dayane Priscilla de Souza; Carollo, Carlos Alexandre; Kadri, Mônica Cristina Toffoli; Rizk, Yasmin Silva; Araujo, Vanessa Carneiro Pereira de; Monteiro, Paulo Eduardo de Oliveira; Rodrigues, Patrik Oening; Oshiro, Elisa Teruya; Matos, Maria de Fátima Cepa; Arruda, Carla Cardozo Pinto de.
Título: In vivo antileishmanial activity and chemical profile of polar extract from Selaginella sellowii
Fonte: Mem. Inst. Oswaldo Cruz;111(3):147-154, Mar. 2016. tab, graf.
Idioma: en.
Resumo: The polar hydroethanolic extract from Selaginella sellowii(SSPHE) has been previously proven active on intracellular amastigotes (in vitro test) and now was tested on hamsters infected with Leishmania (Leishmania) amazonensis (in vivo test). SSPHE suppressed a 100% of the parasite load in the infection site and draining lymph nodes at an intralesional dose of 50 mg/kg/day × 5, which was similar to the results observed in hamsters treated with N-methylglucamine antimonate (Sb) (28 mg/Kg/day × 5). When orally administered, SSPHE (50 mg/kg/day × 20) suppressed 99.2% of the parasite load in infected footpads, while Sb suppressed 98.5%. SSPHE also enhanced the release of nitric oxide through the intralesional route in comparison to Sb. The chemical fingerprint of SSPHE by high-performance liquid chromatography with diode-array detection and tandem mass spectrometry showed the presence of biflavonoids and high molecular weight phenylpropanoid glycosides. These compounds may have a synergistic action in vivo. Histopathological study revealed that the intralesional treatment with SSPHE induced an intense inflammatory infiltrate, composed mainly of mononuclear cells. The present findings reinforce the potential of this natural product as a source of future drug candidates for American cutaneous leishmaniasis.
Descritores: Antiprotozoários/farmacologia
Leishmania/efeitos dos fármacos
Extratos Vegetais/química
-Administração Oral
Antiprotozoários/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Infusões Intralesionais
Leucócitos Mononucleares/parasitologia
Meglumina/administração & dosagem
Óxido Nítrico/análise
Compostos Organometálicos/administração & dosagem
Carga Parasitária
Extratos Vegetais/administração & dosagem
Espectrometria de Massas em Tandem
Limites: Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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