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Texto completo SciELO Cuba
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Id: lil-324908
Autor: Llanes Echevarría, José R.
Título: Soluciones cristaloides y coloides, como sustitutas de la sangre en el cebado del circuito extracorpóreo durante la cirugía cardiovascular / Crystalloid and colloidal solutions as blood substitutes in the priming of the extracorporeal circuit during cardiovascular surgery
Fonte: Rev. cuba. cir;41(1):42-46, ene.-mar. 2002.
Idioma: es.
Resumo: Se realizó un estudio cualitativo donde se exponen las características principales, objetivos de aplicación y las ventajas que ofrecen las diferentes soluciones coloidales y electrolíticas utilizadas en el cebado del circuito extracorpóreo. Como objetivo principal se exponen los argumentos necesarios que permiten al perfusionista combinar determinadas soluciones, para conservar la osmolaridad, la presión oncótica del plasma, mejorar el flujo microcirculatorio y evitar las transfusiones de sangre y hemoderivados innecesarias. También se mencionan diferentes técnicas para conservar el nivel del hematócrito, como son el uso de hemofiltros, concentrador de células y la aplicación de la cardioplejia sanguínea, que aunque su principal objetivo es la protección miocárdica, también sustituye los grandes volúmenes de líquido que caracteriza el uso de la cardioplejia cristaloide(AU)

The chief characteristics, objectives of application and the advantages the colloidal and electrolytic solutions used in the priming of the extracorporeal circuit offer are explained in this qualitative study. The necessary arguments that allow the perfusionist to combine certain solutions to conserve osmolarity, the oncotic pressure of plasma, to improve the microcirculatory flow and to avoid blood transfusions and unnecessary hemoderivatives, are dealt with as the fundamental aim. Reference is made to different techniques used to conserve the haematocrit level, such as: the use of haemofilters, cell concentrator and the application of blood cardioplegia, whose main goal is the myocardial protection, but it also substitutes the great volumes of fluid that characterize the use of crystalloid cardioplegia(AU)
Descritores: Procedimentos Cirúrgicos Cardiovasculares/métodos
Transfusão de Sangue/métodos
Soluções Cardioplégicas/uso terapêutico
Substitutos do Plasma/administração & dosagem
Circulação Extracorpórea/métodos
Parada Cardíaca Induzida/efeitos adversos
-Concentração Osmolar
Coloides
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


  2 / 107 LILACS  
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Id: biblio-843475
Autor: Ramani, Jaydip; Malhotra, Amber; Wadhwa, Vivek; Sharma, Pranav; Garg, Pankaj; Tarsaria, Malkesh; Pandya, Himani.
Título: Single-dose lignocaine-based blood cardioplegia in single valve replacement patients
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);32(2):90-95, Mar.-Apr. 2017. tab.
Idioma: en.
Resumo: Abstract OBJECTIVE: Myocardial protection is the most important in cardiac surgery. We compared our modified single-dose long-acting lignocaine-based blood cardioplegia with short-acting St Thomas 1 blood cardioplegia in patients undergoing single valve replacement. METHODS: A total of 110 patients who underwent single (aortic or mitral) valve replacement surgery were enrolled. Patients were divided in two groups based on the cardioplegia solution used. In group 1 (56 patients), long-acting lignocaine based-blood cardioplegia solution was administered as a single dose while in group 2 (54 patients), standard St Thomas IB (short-acting blood-based cardioplegia solution) was administered and repeated every 20 minutes. All the patients were compared for preoperative baseline parameters, intraoperative and all the postoperative parameters. RESULTS: We did not find any statistically significant difference in preoperative baseline parameters. Cardiopulmonary bypass time were 73.8±16.5 and 76.4±16.9 minutes (P=0.43) and cross clamp time were 58.9±10.3 and 66.3±11.2 minutes (P=0.23) in group 1 and group 2, respectively. Mean of maximum inotrope score was 6.3±2.52 and 6.1±2.13 (P=0.65) in group 1 and group 2, respectively. We also did not find any statistically significant difference in creatine-phosphokinase-MB (CPK-MB), Troponin-I levels, lactate level and cardiac functions postoperatively. CONCLUSION: This study proves the safety and efficacy of long-acting lignocaine-based single-dose blood cardioplegia compared to the standard short-acting multi-dose blood cardioplegia in patients requiring the single valve replacement. Further studies need to be undertaken to establish this non-inferiority in situations of complex cardiac procedures especially in compromised patients.
Descritores: Soluções Cardioplégicas/administração & dosagem
Implante de Prótese de Valva Cardíaca/métodos
Parada Cardíaca Induzida/métodos
Lidocaína/administração & dosagem
-Valva Aórtica/cirurgia
Período Pós-Operatório
Cloreto de Potássio/administração & dosagem
Bicarbonatos/administração & dosagem
Cloreto de Cálcio/administração & dosagem
Cloreto de Sódio/administração & dosagem
Estudos Prospectivos
Resultado do Tratamento
Ácido Láctico/sangue
Troponina I/sangue
Creatina Quinase/sangue
Magnésio/administração & dosagem
Valva Mitral/cirurgia
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


  3 / 107 LILACS  
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Id: biblio-897903
Autor: Lopes, Jackson Brandão; Santos Júnior, Carlos Cezar Monteiro dos.
Título: Coronary perfusion pressure during antegrade cardioplegia in on-pump CABG patients
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);32(3):171-176, May-June 2017. tab, graf.
Idioma: en.
Projeto: Ministério da Ciência, Tecnologia e Inovação, Conselho Nacional de Desenvolvimento Científico e Tecnológico.
Resumo: Abstract Objective: The aim of this study was to investigate whether aortic tension estimated by palpation and cardioplegia infusion line pressure provide results equivalent to those obtained with direct aortic intraluminal pressure measurement. Methods: Sixty consecutive patients who underwent coronary artery bypass graft surgeries with extracorporeal circulation were analyzed. Sanguineous cardioplegic solution in a ratio of 4:1 was administered using a triple lumen antegrade cannula. After crossclamping, cardioplegia was infused and aortic root pressure was recorded by surgeon (A) considering the aortic tension he felt in his fingertips. At the same time, another surgeon (B) recorded his results for the same measurement. Concomitantly, the anesthesiologist recorded intraluminal pressure in the aortic root and the perfusionist recorded delta pressure in cardioplegia infusion line. None of the participants involved in these measurements was allowed to be informed about the values provided by the other examiners. Results: The Bland-Altman test showed that a considerable variation between aortic wall tension was found as measured by palpation and by intraluminal pressure, with a bias of -9.911±18.75% (95% limits of agreement: -46.7 to 26.9). No strong correlation was observed between intraluminal pressure and cardioplegia line pressure (Spearman's r=0.61, 95% confidence interval 0.5-0.7; P<0.0001). Conclusion: These findings reinforce that cardioplegia infusion should be controlled by measuring intraluminal pressure, and that palpation and cardioplegia line pressure are inaccurate methods, the latter should always be used to complement intraluminal measurement to ensure greater safety in handling the cardioplegia circuit.
Descritores: Aorta/fisiologia
Pressão Venosa/fisiologia
Reperfusão Miocárdica/métodos
Ponte de Artéria Coronária/métodos
Circulação Coronária/fisiologia
Parada Cardíaca Induzida/métodos
-Aorta/cirurgia
Palpação
Valores de Referência
Fatores de Tempo
Soluções Cardioplégicas
Índice de Massa Corporal
Variações Dependentes do Observador
Estudos Prospectivos
Reprodutibilidade dos Testes
Monitorização Intraoperatória/métodos
Resultado do Tratamento
Estatísticas não Paramétricas
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


  4 / 107 LILACS  
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Id: biblio-958403
Autor: Carmo, Helison Pereira do; Reichert, Karla; Carvalho, Daniela Diógenes de; Silveira-Filho, Lindemberg da Mota; Vilarinho, Karlos; Oliveira, Pedro; Petrucci, Orlando.
Título: Lidocaine and pinacidil added to blood versus crystalloid cardioplegic solutions: study in isolated hearts
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);33(3):211-216, May-June 2018. tab, graf.
Idioma: en.
Projeto: Fundação de Amparo à Pesquisa do Estado de São Paulo.
Resumo: Abstract Objective: The present study aimed the functional recovery evaluation after long term of cardiac arrest induced by Custodiol (crystalloid-based) versus del Nido (blood-based) solutions, both added lidocaine and pinacidil as cardioplegic agents. Experiments were performed in isolated rat heart perfusion models. Methods: Male rat heart perfusions, according to Langendorff technique, were induced to cause 3 hours of cardiac arrest with a single dose. The hearts were assigned to one of the following three groups: (I) control; (II) Custodiol-LP; and (III) del Nido-LP. They were evaluated after ischemia throughout 90 minutes of reperfusion. Left ventricular contractility function was reported as percentage of recovery, expressed by developed pressure, maximum dP/dt, minimum dP/dt, and rate pressure product variables. In addition, coronary resistance and myocardial injury marker by alpha-fodrin degradation were also evaluated. Results: At 90 minutes of reperfusion, both solutions had superior left ventricular contractile recovery function than the control group. Del Nido-LP was superior to Custodiol-LP in maximum dP/dt (46%±8 vs. 67%±7, P<0.05) and minimum dP/dt (31%±4 vs. 51%±9, P<0.05) variables. Coronary resistance was lower in del Nido-LP group than in Custodiol-LP (395%±50 vs. 307%±13, P<0.05), as well as alpha-fodrin degradation, with lower levels in del Nido-LP group (P<0.05). Conclusion: Del Nido-LP cardioplegia showed higher functional recovery after 3 hours of ischemia. The analysis of alpha-fodrin degradation showed del Nido-LP solution provided greater protection against myocardial ischemia and reperfusion (IR) in this experimental model.
Descritores: Soluções Cardioplégicas/farmacologia
Reperfusão Miocárdica/métodos
Compostos de Potássio/farmacologia
Pinacidil/farmacologia
Parada Cardíaca Induzida/métodos
Lidocaína/farmacologia
-Fatores de Tempo
Resistência Vascular/fisiologia
Soluções Cardioplégicas/química
Proteínas de Transporte/análise
Western Blotting
Ratos Wistar
Vasos Coronários/fisiopatologia
Glucose/farmacologia
Glucose/química
Coração/efeitos dos fármacos
Manitol/farmacologia
Manitol/química
Proteínas dos Microfilamentos/análise
Limites: Animais
Masculino
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME


  5 / 107 LILACS  
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Id: biblio-1013474
Autor: Carmo, Helison Pereira do.
Título: Response by authors to the letter regarding article "lidocaine and pinacidil added to blood versus crystalloid cardioplegic solutions: study in isolated hearts"
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);34(3):381-381, Jun. 2019.
Idioma: en.
Descritores: Soluções Cristaloides
Lidocaína
-Soluções Cardioplégicas
Pinacidil
Coração
Parada Cardíaca Induzida
Tipo de Publ: Comentário
Carta
Responsável: BR1.1 - BIREME


  6 / 107 LILACS  
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Id: biblio-1137349
Autor: Mercan, Ilker; Dereli, Yuksel; Topcu, Cemile; Tanyeli, Omer; Isik, Mehmet; Gormus, Niyazi; Ozturk, Elifnur Yildirim.
Título: Comparison between the effects of bretschneiders htk solution and cold blood cardioplegia on systemic endothelial functions in patients who undergo coronary artery bypass surgery: a prospective randomized and controlled trial
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);35(5):634-643, Sept.-Oct. 2020. tab, graf.
Idioma: en.
Resumo: Abstract Objective: To investigate the effects of Bretschneider's histidine-tryptophan-ketoglutarate (HTK) solution and cold blood cardioplegia on systemic endothelial functions. Methods: A total of 50 patients who underwent isolated coronary artery bypass surgery between March 2018 and May 2018 were randomly divided into two groups - group 1 (Bretschneider's HTK solution, n=25) and group 2 (cold blood cardioplegia, n=25). Data related to the indicators of endothelial dysfunction were recorded. Flow-mediated dilation was measured together with the assessment of the values of endothelin-1, von Willebrand factor, and asymmetric dimethylarginine to identify endothelial dysfunction. Then, the two groups were compared regarding these values. Results: The most significant result of our study was that the endothelin-1 level was significantly higher in group 2 than in group 1 (P<0.001). The value of flow-mediated dilation was found to increase to a lesser degree on the postoperative days compared to the value at the day of admission in group 1 (P=0.002 and P=0.030, respectively). Conclusion: Cardiopulmonary bypass leads to endothelial dysfunction. Our results revealed that Bretschneider's HTK solution causes less severe endothelial injury than cold blood cardioplegia.
Descritores: Soluções Cardioplégicas/uso terapêutico
Ponte de Artéria Coronária
Parada Cardíaca Induzida
-Cloreto de Potássio
Procaína
Estudos Prospectivos
Glucose
Manitol
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Research Support, Non-U.S. Gov't
Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


  7 / 107 LILACS  
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Id: biblio-977469
Autor: Preusse, Claus J.
Título: Comment on "Lidocaine and pinacidil added to blood versus crystalloid cardioplegic solutions: study in isolated hearts"
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);33(6):638-639, Nov.-Dec. 2018. graf.
Idioma: en.
Descritores: Pinacidil
Soluções Cristaloides
-Soluções Cardioplégicas
Coração
Parada Cardíaca Induzida
Lidocaína
Tipo de Publ: Comentário
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-1137343
Autor: Orak, Yavuz; Kocarslan, Aydemir; Boran, Omer Faruk; Acıpayam, Mehmet; Eroglu, Erdinc; Kirisci, Mehmet; Doganer, Adem.
Título: Comparison of the operative and postoperative effects of del Nido and blood cardioplegia solutions in cardiopulmonary bypass surgery
Fonte: Rev. bras. cir. cardiovasc = Braz. j. cardiovasc. surg. (impr.);35(5):689-696, Sept.-Oct. 2020. tab.
Idioma: en.
Resumo: Abstract Objective: Our goal was to compare the operative and postoperative effects of del Nido cardioplegia (DN group) and blood cardioplegia (BC group) performed in cardiac surgery. Methods: A total of 83 patients were included, separated into DN group and BC group. The operative and postoperative effects of the two groups were compared for the first 24 hours until extubation. The operative and postoperative complete blood count (CBC), biochemical values and clinical parameters were compared. Results: The first control activated clotting time (ACT) levels in DN group patients were lower (P=0.003) during the operation. The amount of cardioplegia in DN group were lower than that in BC group (P=0.001). The pump outflow and postoperative lactate level of DN group were lower than those of BC group (P=0.005, P=0.018, respectively), as well as the amounts of NaHCO3 (P=0.006) and KCl (P=0.001) used during the operation. The same occurred with the first monocytes (Mo) and mean corpuscular volume (MCV) levels in the postoperative intensive care unit (P=0.006, P=0.002). However, the first glucose level and the eosinophil (Eo) level were higher in DN group (P=0.011, P=0.047, respectively). Conclusion: In the operative evaluation, the amount of cardioplegia, the first ACT levels, the pump outflow lactate level and the amounts of NaHCO3 and KCl in DN group were lower. In postoperative evaluation, measured level of lactate, Mo and MCV in DN group were all lower; their glucose and Eo levels were higher.
Descritores: Ponte Cardiopulmonar
Procedimentos Cirúrgicos Cardíacos
-Período Pós-Operatório
Soluções Cardioplégicas/uso terapêutico
Parada Cardíaca Induzida
Limites: Humanos
Masculino
Feminino
Responsável: BR1.1 - BIREME


  9 / 107 LILACS  
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Id: lil-360612
Autor: Dinkhuysen, Jarbas J.
Título: Bicaval/bipulmonary Orthotopic Heart Transplantation
Fonte: Rev. bras. cir. cardiovasc;18(3):268-272, July-Sept. 2003. ilus.
Idioma: en.
Resumo: O autor descreve técnica para realizaçäo de transplante cardíaco bicaval-bipulmonar, incluindo avaliaçäo, retirada e conservaçäo do órgäo do doador. Além disso, säo descritos o esquema de imunossupressäo pré-operatória, as técnicas de proteçäo miocárdica, ressecçäo do coraçäo nativo e implante do órgäo doado.
Descritores: Transplante Homólogo
Transplante de Coração/métodos
-Insuficiência Cardíaca
Parada Cardíaca Induzida
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


  10 / 107 LILACS  
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Id: lil-62723
Autor: Gomes, Otoni Moreira; Ledoux, Delio S; Fiorelli, Alfredo I; Brum, José Mauro Goulart; Calonge, Haroldo de C. F; Salles, Dora D. F; Moraes, Nelson L. T. B; Amaral, Ruy Vaz Gomide do; Bittencourt, Delmont; Armelin, Egas; Zerbini, Euryclides de Jesus.
Título: Proteçäo miocárdica para cirurgia cardíaca estudo experimental de nova soluçäo cardioplégica, a análise de ainfluência da concentraçäo de potássio / Myocardial protection during cardiac surgery: experimental study of new cardioplegig solution and analysis of the effect of potassium concentration
Fonte: Ars cvrandi cardiol;4(18):33-4, 37-42, 44, passim, mar. 1982. ilus, tab.
Idioma: pt.
Resumo: Foram estudados 23 cäes mestiços, submetidos à toracotomia, circulaçäo extracorpórea hipotérmica (28-C), cardioplegia e parada cardíaca com três horas de duraçäo. Estes animais foram distribuídos nos seguintes grupos: Grupo I - sete cäes submetidos à perfusäo coronária com 6 ml/Kg de peso corpóreo de soluçäo de Ringer com pH corrigido para 7,5 - 7,7 por bicarbonato de sódio; Grupo II - oito cäes submetidos à cardioplegia com soluçäo de Ringer (pH 7,5 - 7,7_ acrescida de potássio (concentraçäo de 25,0 mEq/1); Grupo III oito cäes estudados com nova soluçäo cardioplégica
Descritores: Cirurgia Torácica
Miocárdio
Potássio/metabolismo
Soluções Cardioplégicas
-Parada Cardíaca Induzida
Limites: Cães
Tipo de Publ: Revisão
Responsável: BR79.1 - CIC - Centro de Informação Cardiovascular Mendonça de Barros



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