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Id: lil-787899
Autor: Skinovsky, James; Tsumanuma, Fernanda Keiko; Sigwalt, Marcos Fabiano; Panegalli-Filho, Flávio; Kawakubo, Adriana Mitie; Rolim, Bruna Gimenes; Godoy, Luciana Andrade de.
Título: Thirty kilograms giant retroperitoneal teratoma: case report / Teratoma retroperitoneal gigante de 30 kg: relato de caso
Fonte: ABCD arq. bras. cir. dig;29(2):128-129graf.
Idioma: en.
Descritores: Neoplasias Retroperitoneais/patologia
Teratoma/patologia
-Neoplasias Retroperitoneais/cirurgia
Teratoma/cirurgia
Carga Tumoral
Limites: Humanos
Masculino
Adulto
Tipo de Publ: Relatos de Casos
Carta
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Id: biblio-1001041
Autor: Gasparini-Junior, José Luiz; Fanelli, Marcello Ferretti; Abdallah, Emne Ali; Chinen, Ludmilla Thomé Domingos.
Título: Evaluating mmp-2 and tgfß-ri expression in circulating tumor cells of pancreatic cancer patients and their correlation with clinical evolution / Avaliação da expressão de mmp-2 e tgfß-ri em células tumorais circulantes de pacientes com câncer de pâncreas e sua correlação com evolução clínica
Fonte: ABCD arq. bras. cir. dig;32(2):e1433, 2019. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: ABSTRACT Background: Metastasis is common in the diagnosis of pancreatic cancer, and the presence of epithelial-mesenchymal transition markers in circulating tumor cells may suggest worse prognosis. Aim: To correlate the number of circulating tumor cells (CTCs) in the peripheral blood of patients with a locally advanced or metastatic pancreatic tumor and the protein expression involved in epithelial-mesenchymal transition (EMT) in CTCs with clinical characteristics, progression-free survival (PFS) and overall survival (OS). Method: This was a prospective study conducted using peripheral blood samples collected at three different times. CTCs were quantified by the ISET test and analyzed by immunocytochemistry. Proteins involved in EMT (vimentin, TGFß-RI and MMP2) were analyzed in all CTCs. Results: Twenty-one patients were included. Median CTCs detected were 22, 20 and 8 CTCs/8 ml blood at baseline, first and second follow-up, respectively. No statistically significant correlation was found in correlating the number of CTCs and the evaluated clinical characteristics, PFS, or OS. There was no difference in PFS and OS among the EMT markers in the groups with and without markers. Conclusion: CTC analysis was not relevant in this sample for comparing clinical findings, PFS and OS in patients with pancreatic cancer. However, marker analysis in CTCs could be useful for the MMP-2 and/or TGFß-RI expression, as observed by the separate PFS curve.

RESUMO Racional: A metástase é comum no diagnóstico de câncer de pâncreas; presença de marcadores de transição epitélio-mesenquimal nas células tumorais circulantes (CTCs) podem sugerir pior prognóstico. Objetivo: Correlacionar o número de CTCs no sangue periférico de pacientes com tumor de pâncreas localmente avançado ou metastático e expressão de proteínas envolvidas na transição epitélio-mesenquimal (TEM) nas CTCs com características clínicas, sobrevida livre de progressão (SLP) e global (SG). Método: Estudo prospectivo realizado por meio de coletas de sangue periférico em três tempos distintos. As CTCs foram quantificadas pelo sistema ISET e analisadas por imunocitoquímica. Proteínas envolvidas na TEM (vimentina, TGFß-RI e MMP2) foram analisadas em todas as CTCs. Resultados: Foram incluídos 21 pacientes. A mediana de CTCs detectadas foi de 22, 20 e 8 CTCs/8 ml de sangue no baseline, primeiro e segundo seguimentos, respectivamente. Na correlação entre número de CTCs e as características clínicas levantadas, SLP, SG não houve correlação estatisticamente significante. Nos marcadores de TEM não houve diferença de SLP e SG entre os grupos que apresentaram e não apresentaram marcação. Conclusão: As CTCs não se mostraram relevantes na comparação dos achados clínicos, SLP e SG em pacientes com câncer de pâncreas. No entretanto, pode ser que para a análise de marcador seja útil, como observado pelas curvas separadas de expressão de MMP-2 e TGFß-RI nas CTCs.
Descritores: Neoplasias Pancreáticas/sangue
Adenocarcinoma/sangue
Metaloproteinase 2 da Matriz/sangue
Receptor do Fator de Crescimento Transformador beta Tipo I/sangue
Células Neoplásicas Circulantes/química
-Neoplasias Pancreáticas/patologia
Valores de Referência
Fatores de Tempo
Vimentina/sangue
Adenocarcinoma/patologia
Biomarcadores Tumorais/sangue
Estudos Prospectivos
Progressão da Doença
Carga Tumoral
Estimativa de Kaplan-Meier
Transição Epitelial-Mesenquimal
Gradação de Tumores
Células Neoplásicas Circulantes/patologia
Estadiamento de Neoplasias
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: biblio-961411
Autor: Guevara, David Ladrón de; Pavez, Gonzalo; Zapata, Jaime; Romero, Claudio; Tapia, Valezka; Buckel, Erwin; Ferrario, Mario.
Título: Utilidad pronóstica del PET/CT en cáncer de páncreas / Prognostic value of PET/CT in pancreatic cancer
Fonte: Rev. méd. Chile;146(4):413-421, abr. 2018. tab, graf.
Idioma: es.
Resumo: Background: Pancreatic cancer is the tenth most prevalent cancer in world, and represents the fourth cause of cancer death. It has a five year-survival of 5%. Aim: To assess the prognostic value of PET/CT in pancreatic cancer. Material and Methods: Sixty-nine patients with pancreatic adenocarcinoma who underwent staging 18F-fluorodeoxyglucose (FDG) PET/CT between December 2008 and July 2016 were selected. Gender, age, body-mass index, laboratory tests (Ca 19-9, hemoglobin, erythrocyte sedimentation rate, liver enzymes, lactate dehydrogenase), histological differentiation of tumor, American Joint Committee on Cancer (AJCC) stage, size and 18F-FDG uptake (maximal stan-dardized uptake value [SUVmax]) of the primary tumor, nodal involvement and distant metastasis detected by PET/CT were registered. Survival was assessed using Kaplan-Meier curves, Log Rank test and Cox multivariable analysis. Results: Mortality was 66.7%, during a mean observation time of 18 months (range 20 days-66 months). Curative surgery, lack of metastases detected by PET/CT, histologically well differentiated tumors, and SUVmax ≤ 4.3 were significantly associated with a better specific survival, determined by the Log Rank test. Histological differentiation was the only variable that had a statistically significant prognostic value in the multivariable analysis. Conclusions: The detection of distant metastases and the intensity of primary tumor 18F-FDG uptake during PET/CT provide useful prognostic information in pancreatic cancer patients.
Descritores: Neoplasias Pancreáticas/diagnóstico por imagem
Adenocarcinoma/diagnóstico por imagem
-Neoplasias Pancreáticas/mortalidade
Neoplasias Pancreáticas/patologia
Prognóstico
Fatores de Tempo
Adenocarcinoma/mortalidade
Adenocarcinoma/patologia
Análise de Sobrevida
Estudos Retrospectivos
Seguimentos
Compostos Radiofarmacêuticos/administração & dosagem
Compostos Radiofarmacêuticos/farmacocinética
Fluordesoxiglucose F18/administração & dosagem
Fluordesoxiglucose F18/farmacocinética
Carga Tumoral
Gradação de Tumores
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada/métodos
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Responsável: CL1.1 - Biblioteca Central


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Id: lil-777233
Autor: OLIVEIRA, Maria Laura Cosetti; WAGNER, Vivian Petersen; SANT'ANA FILHO, Manoel; CARRARD, Vinicius Coelho; HUGO, Fernando Neves; MARTINS, Manoela Domingues.
Título: A 10-year analysis of the oral squamous cell carcinoma profile in patients from public health centers in Uruguay
Fonte: Braz. oral res. (Online);29(1):1-8, 2015. tab.
Idioma: en.
Resumo: The aim of this study was to evaluate the demographic, clinical, and therapeutic characteristics and predictive factors of poor prognosis in patients with primary oral squamous cell carcinoma (OSCC) in Uruguay. Medical records of patients with the diagnosis of primary OSCC treated between 2000 and 2010 in Uruguayan public hospitals were selected. Data on demographic characteristics, risk factors, clinical features, treatment, and outcome were collected. Associations of independent variables with outcomes were assessed using Pearson chi-squared and Fisher's tests. Of 200 patients with OSCC, 79.4% were men (3.8:1 male:female ratio), with a mean age of 60.75 ± 11.26 years. Tobacco and alcohol consumption were reported by 85.3% and 63.5% of patients, respectively. The most commonly affected location was the tongue (42.5%), with lesions exhibiting ulcerous aspects in 87.9% of cases and pain at the time of diagnosis in 70.4% of cases. One hundred sixty-one (82.1%) patients had advanced-stage (III/IV) OSCC. Surgery was the most common treatment option, and the overall 5-year survival rate was 58.5%. Univariate analysis showed that the predictors of poor prognosis were clinical aspect, size, regional metastasis, clinical stage, and treatment. In Uruguay, OSCC is diagnosed late, which is associated with a low survival rate. Educational and preventive measures and investment to improve early diagnosis should be undertaken.
Descritores: Carcinoma de Células Escamosas/epidemiologia
Carcinoma de Células Escamosas/patologia
Neoplasias Bucais/epidemiologia
Neoplasias Bucais/patologia
-Consumo de Bebidas Alcoólicas/efeitos adversos
Consumo de Bebidas Alcoólicas/epidemiologia
Carcinoma de Células Escamosas/terapia
Neoplasias Bucais/terapia
Prognóstico
Fatores de Risco
Distribuição por Sexo
Fatores Sexuais
Fumar/efeitos adversos
Fumar/epidemiologia
Fatores de Tempo
Neoplasias da Língua/epidemiologia
Neoplasias da Língua/patologia
Neoplasias da Língua/terapia
Carga Tumoral
Uruguai/epidemiologia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-978745
Autor: DÍAZ PATIÑO, JUAN CARLOS; ALEGRÍA BOBADILLA, JULIA; LEAL MARTÍNEZ, EMA; PIRES, YUMAY; CHONG MEDEL, GUILLERMO; SILVA FUENTE-ALBA, CLAUDIO; RAMOS GÓMEZ, G. CRISTÓBAL.
Título: Presentación atípica de neoplasia pulmonar: lesiones quísticas pulmonares "no siempre benignas" / Lung cancer presenting as cystic lesions: report of eight cases
Fonte: Rev. méd. Chile;146(10):1102-1111, dic. 2018. tab, graf.
Idioma: es.
Resumo: Background:: Pulmonary cystic nodules are a relatively frequent finding in chest computed tomography (CT). There is a possible association between this finding and lung cancer. Aim: To report eight patients with malignant lung cystic lesions. Material and Methods: Retrospective analysis of images in a CT database from 2007 to 2015, looking for cystic lesions of the lung with wall thickening, whose pathological diagnosis was lung cancer. Results: We identified eight patients with cystic nodules aged 44 to 77 years, of which five were women. Six were active and two former smokers. The pathological diagnosis was adenocarcinoma in seven cases and squamous cell in one. The mean diameter of the cystic lesions was 11.5 mm. The mean diagnostic delay time was 871 days (range 0-1592). The main finding was a gradual thickening of the nodule walls. Conclusions: The presentation of lung cancer as cystic nodules is uncommon. In this series, the change in morphology due to a thickening of the walls with or without a diameter increase, was the clue for the diagnosis.
Descritores: Carcinoma de Células Escamosas/patologia
Adenocarcinoma/patologia
Cistos/patologia
Neoplasias Pulmonares/patologia
-Biópsia
Carcinoma de Células Escamosas/diagnóstico por imagem
Adenocarcinoma/diagnóstico por imagem
Fumar/efeitos adversos
Estudos Retrospectivos
Cistos/diagnóstico por imagem
Carga Tumoral
Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada
Neoplasias Pulmonares/diagnóstico por imagem
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Responsável: CL1.1 - Biblioteca Central


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Id: lil-755869
Autor: Allaei, Atabak; Lang, Erich K.
Título: Retroperitoneal Hygroma
Fonte: Int. braz. j. urol;41(3):596-597, May-June 2015. ilus.
Idioma: en.
Resumo: ABSTRACT :We present a 46-year-old white male with a retroperitoneal hygroma protruding from the right flank
Descritores: Neoplasias Retroperitoneais/diagnóstico por imagem
Linfangioma Cístico/diagnóstico por imagem
-Tomografia Computadorizada por Raios X/métodos
Carga Tumoral
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Tipo de Publ: Relatos de Casos
Responsável: BR1.1 - BIREME


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Id: lil-748285
Autor: Ozturk, Hakan.
Título: High-grade Primary Renal Leiomyosarcoma
Fonte: Int. braz. j. urol;41(2):304-311, Mar-Apr/2015. tab, graf.
Idioma: en.
Resumo: Objective: To investigate the clinical characteristics, prognosis, survival and diagnosis of high-grade primary renal leiomyosarcoma. Materials and Methods: From January 2003 to April 2013, 10 cases of high-grade primary renal leiomyosarcoma were retrospectively reviewed. We analyzed clinical manifestations, treatment and prognosis of our group and correlated to the literature. Results: Ten cases (five male and five female patients; age range 43­77 years, mean=57±std d:12.3 ) were enrolled. The mean diameter of the tumor masses was 9.35±4.5 cm (range 3-18 cm). 40% of the patients were asymptomatic while the major symptom of 60% patients was lumbar pain. Nephrectomy was performed in 90% of patients. Partial nephrectomy surgery was preferred for only one patient. Pleomorphism and necrosis with high-grade, pink spindle cell cytoplasm were viewed in all patients. All patients were high-grade, pink spindle cell cytoplasm and pleomorfism and necrosis were observed in all. In an immunohistochemical examination, vimentin was seen in 100%, desmin in 90% and smooth muscle actin in 80% of the patients. CD117 was negative in all patients. All of the cases were followed-up, and the time of survival varied from 6 to 68 months (mean 23.9±std d:20.1). No patient received adjuvant CTx and/or RTx. Conclusion: High-grade primary renal leiomyosarcomas (LMSs) are rare and highly malignant and the prognosis is poor. Early diagnosis and radical nephrectomy can prolong the patient's life. Surgery is the main treatment modality for renal (leiomyosarcoma) LMS
Descritores: Neoplasias Renais/cirurgia
Neoplasias Renais/patologia
Leiomiossarcoma/cirurgia
Leiomiossarcoma/patologia
-Prognóstico
Imuno-Histoquímica
Imageamento por Ressonância Magnética
Estudos Retrospectivos
Carga Tumoral
Rim/cirurgia
Rim/patologia
Neoplasias Renais/mortalidade
Leiomiossarcoma/mortalidade
Pessoa de Meia-Idade
Necrose/patologia
Nefrectomia/métodos
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-796889
Autor: Otunctemur, Alper; Dursun, Murat; Ozer, Kutan; Horsanali, Ozan; Ozbek, Emin.
Título: Renal cell carcinoma and visceral adipose index: a new risk parameter
Fonte: Int. braz. j. urol;42(5):955-959, Sept.-Oct. 2016. tab.
Idioma: en.
Resumo: ABSTRACT Purpose: The aim of this study was to evaluate the relationship between tumor size and grade with visceral adipose index (VAI) levels in patients with renal cell carcinoma. Materials and methods: We retrospectively reviewed the records of 310 consecutive patients with RCC who underwent radical nephrectomy at our institution between January 2007 and May 2014. VAI was calculates for males and females seperately as this formula like previous study. The relationship between tumor size and nuclear grade with VAI levels were evaluated statisticaly. Analyses were completed using Chi-square tests and Logistic regression analysis. Results: Among the 310 total patients analyzed in our study, there were 176 males (56.8%) and 134 females (43.2%). VAI levels were statistically higher in men and women with high tumor size (p<0.001). VAI levels were statistically higher in men and women with high fuhrman grade (p<0.001). Conclusions: The components of VAI may have effect on tumor carcinogenesis in similar pathways. In our study patients with high VAI levels were found to have statistically significant higher nuclear grade and tumor size. VAI can be a useful index for the evaluation and calculation of renal cell cancer aggressiviness. Further studies with more patients are needed to confirm our study.
Descritores: Carcinoma de Células Renais/patologia
Medição de Risco/métodos
Carga Tumoral
Gordura Intra-Abdominal/patologia
Neoplasias Renais/patologia
-Índice de Massa Corporal
Modelos Logísticos
Fatores Sexuais
Estudos Retrospectivos
Fatores de Risco
Circunferência da Cintura
Gradação de Tumores
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: lil-777315
Autor: Park, Dong Soo; Hong, Young Kwon; Lee, Seung Ryeol; Hwang, Jin Ho; Kang, Moon Hyung; Oh, Jong Jin.
Título: Three-dimensional reconstructive kidney volume analyses according to the endophytic degree of tumors during open partial or radical nephrectomy
Fonte: Int. braz. j. urol;42(1):37-46, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Objectives To investigate the renal function outcomes and contralateral kidney volume change measured by using a 3-dimensional reconstructive method after open partial nephrectomy (PN) or open radical nephrectomy (RN) according to the endophytic degree of tumors. Materials and Methods We included 214 PN and 220 RN patients. According to the endophytic degree of the tumors, we divided patients into 3 groups. Patients were assessed for renal function and kidney volume change both preoperatively and postoperatively at 6 months. Kidney volume was calculated by using personal computer-based software. Subgroup analyses was performed for tumor >4cm. Results Larger and complex tumors were more frequent in the RN group than PN group. Among patients with exophytic and mild endophytic tumors, the mean postoperative renal function was well preserved in PN group and the mean contralateral kidney volume significantly increased in the RN compared to the PN group (PN, 145.55 to 149.98mL; 3.0% versus RN, 143.93 to 169.64mL;17.9% p=0.006). However, in fully endophytic tumors, compensatory hypertrophy of the contralateral kidney was similar between PN and RN (PN, 138.16 to 159.64mL; 15.5 % versus RN, 138.65 to 168.04mL; 21.2% p=0.416) and renal functional outcomes were similar between both groups. These results were also confirmed in tumors >4cm in size. Conclusions In fully endophytic tumors, especially large tumors, the postoperative renal function and contralateral kidney volume were similar; therefore, we should consider RN preferentially as surgical option for these tumors.
Descritores: Carcinoma de Células Renais/cirurgia
Carcinoma de Células Renais/patologia
Rim/patologia
Neoplasias Renais/cirurgia
Neoplasias Renais/patologia
Nefrectomia/métodos
-Tamanho do Órgão
Período Pós-Operatório
Carcinoma de Células Renais/fisiopatologia
Tomografia Computadorizada por Raios X
Estudos Prospectivos
Resultado do Tratamento
Estatísticas não Paramétricas
Recuperação de Função Fisiológica
Carga Tumoral
Gradação de Tumores
Taxa de Filtração Glomerular
Rim/fisiopatologia
Rim/diagnóstico por imagem
Neoplasias Renais/fisiopatologia
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Adulto
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-777319
Autor: Yuksel, Ozgur Haki; Verit, Ayhan; Sahin, Aytac; Urkmez, Ahmet; Uruc, Fatih.
Título: White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker
Fonte: Int. braz. j. urol;42(1):53-59, Jan.-Feb. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT Purpose The aim of the study was to investigate white blood cell counts and neutrophil to lymphocyte ratio (NLR) as markers of systemic inflammation in the diagnosis of localized testicular cancer as a malignancy with initially low volume. Materials and Methods Thirty-six patients with localized testicular cancer with a mean age of 34.22±14.89 years and 36 healthy controls with a mean age of 26.67±2.89 years were enrolled in the study. White blood cell counts and NLR were calculated from complete blood cell counts. Results White blood cell counts and NLR were statistically significantly higher in patients with testicular cancer compared with the control group (p<0.0001 for all). Conclusions Both white blood cell counts and NLR can be used as a simple test in the diagnosis of testicular cancer besides the well-known accurate serum tumor markers as AFP (alpha fetoprotein), hCG (human chorionic gonadotropin) and LDH (lactate dehydrogenase).
Descritores: Neoplasias Testiculares/diagnóstico
Neoplasias Testiculares/sangue
Linfócitos
Neoplasias Embrionárias de Células Germinativas/diagnóstico
Neoplasias Embrionárias de Células Germinativas/sangue
Neutrófilos
-Prognóstico
Valores de Referência
Neoplasias Testiculares/patologia
Varicocele/sangue
Hemoglobinas/análise
Biomarcadores Tumorais/sangue
Estudos de Casos e Controles
Reprodutibilidade dos Testes
Estudos Retrospectivos
Curva ROC
Neoplasias Embrionárias de Células Germinativas/patologia
Estatísticas não Paramétricas
Contagem de Linfócitos
Carga Tumoral
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Adulto
Responsável: BR1.1 - BIREME



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