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Cardoso, Gilberto Perez
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Id: biblio-837995
Autor: Luz, Flávio Barbosa; Ferron, Camila; Cardoso, Gilberto Perez.
Título: Analysis of effectiveness of a surgical treatment algorithm for basal cell carcinoma
Fonte: An. bras. dermatol;91(6):726-731, Nov.-Dec. 2016. tab, graf.
Idioma: en.
Resumo: Abstract BACKGROUND: Surgical excision is the treatment of choice for basal cell carcinoma and micrographic surgery considered the gold standard, however not yet used routinely worldwide available, as in Brazil. Considering this, a previously developed treatment guideline, which the majority of tumors were treated by conventional technique (not micrographic) was tested. OBJECTIVE: To establish the recurrence rate of basal cell carcinomas treated according to this guideline. METHOD: Between May 2001 and July 2012, 919 basal cell carcinoma lesions in 410 patients were treated according to the proposed guideline. Patients were followed-up and reviewed between September 2013 and February 2014 for clinical, dermatoscopic and histopathologic detection of possible recurrences. RESULTS: After application of exclusion criteria, 520 lesions were studied, with 88.3% primary and 11.7% recurrent tumors. Histological pattern was indolent in 85.5%, 48.6% were located in high risk areas and 70% small tumors. Only 7.3% were treated by Mohs micrographic surgery. The recurrence rate, in an average follow-up period of 4.37 years, was 1.3% for primary and 1.63% for recurrent tumors. Study limitations: unicenter study, with all patients operated on by the same surgeon. CONCLUSION: The treatment guideline utilized seems a helpful guide for surgical treatment of basal cell carcinoma, especially if micrographic surgery is not available.
Descritores: Neoplasias Cutâneas/cirurgia
Algoritmos
Carcinoma Basocelular/cirurgia
-Neoplasias Cutâneas/patologia
Carcinoma Basocelular/patologia
Reprodutibilidade dos Testes
Seguimentos
Cirurgia de Mohs/métodos
Resultado do Tratamento
Guias de Prática Clínica como Assunto
Medição de Risco
Carga Tumoral
Recidiva Local de Neoplasia
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


  2 / 101 LILACS  
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Id: biblio-827747
Autor: Kondo, Rogerio Nabor; Pavezzi, Priscila Daiane; Crespigio, Jefferson; Okamura, Hélio Toshikazu.
Título: Giant cell tumors of the tendon sheath in the left hallux
Fonte: An. bras. dermatol;91(5):704-704, Sept.-Oct. 2016. graf.
Idioma: en.
Descritores: Neoplasias de Tecidos Moles/patologia
Hálux/patologia
Tumores de Células Gigantes/patologia
-Tendões/patologia
Carga Tumoral
Limites: Seres Humanos
Masculino
Meia-Idade
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


  3 / 101 LILACS  
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Amaro Junior, Edson
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Id: lil-621524
Autor: Silva, André César da; Cabral, Francisco Romero; Mamani, Javier Bustamante; Malheiros, Jackeline Moraes; Polli, Roberson Saraiva; Tannus, Alberto; Vidoto, Edson; Martins, Mateus José; Sibov, Tatiana Tais; Pavon, Lorena Favaro; Miyaki, Liza Aya Mabuchi; Cárdenas, Walter Humberto Zavala; Malheiros, Suzana Maria Fleury; Brandt, Reynaldo André; Amaro Junior, Edson; Gamarra, Lionel Fernel.
Título: Tumor growth analysis by magnetic resonance imaging of the C6 glioblastoma model with prospects for the assessment of magnetohyperthermia therapy / Monitoramento por imagem de ressonância magnética do crescimento tumoral no modelo C6 de glioblastoma com perspectivas de avaliação da terapia de magnetohipertemia
Fonte: Einstein (Säo Paulo);10(1):11-15, jan.-mar. 2012. ilus.
Idioma: en; pt.
Descritores: Neoplasias Encefálicas/terapia
Glioblastoma/terapia
Hipertermia Induzida/métodos
Terapia de Campo Magnético/métodos
Imagem por Ressonância Magnética
-Neoplasias Encefálicas/patologia
Linhagem Celular Tumoral/transplante
Lobo Frontal/patologia
Glioblastoma/patologia
Ratos Wistar
Carga Tumoral
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


  4 / 101 LILACS  
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Id: biblio-887446
Autor: Rosière, Nicolás I; Falcioni, Alejandra G; Navacchia, Daniel; Giambini, Daniel.
Título: Lipoblastoma retroperitoneal gigante: Caso dínico / Giant retroperitoneal lipoblastoma: Case report
Fonte: Arch. argent. pediatr;116(1):139-142, feb. 2018. ilus.
Idioma: es.
Resumo: El lipoblastoma forma parte de los tumores derivados del tejido adiposo. Es una neoplasia benigna que se puede presentar de forma localizada o difusa, que afecta a niños en la primera infancia y que, generalmente, se localiza en el tronco y las extremidades. Estos tumores son poco frecuentes en la edad pediátrica, pero cuando uno de ellos se presenta, constituye un desafío que se debe resolver rápidamente por el riesgo de malignidad que implican otras lesiones neoplásicas, de similares características. El diagnóstico preoperatorio es dificultoso, ya que los métodos por imágenes no aportan información específica que permita diferenciarlos de otros tumores, como los liposarcomas. El diagnóstico definitivo es anatomopalógico y, en casos dudosos, es necesaria la confirmación citogenética. Se presenta el caso de un niño de 14 meses de edad con diagnóstico de lipoblastoma de localización retroperitoneal de gran tamaño.

Lipoblastoma is part of tumors derived from adipose tissue. It is a benign neoplasm that can be localized or diffuse, affecting children in early childhood and usually located in the trunk and extremities. These tumors are uncommon in the pediatric age, but when one of them is present, it is a challenge that we must resolve quickly due to the risk of malignancy that involves other similar neoplastic lesions. The preoperative diagnosis is difficult, because the imaging methods do not provide specific information that allows us to differentiate them from other tumors, such as liposarcomas. The definitive diagnosis is anatomopathological and, in doubtful cases, cytogenetic confirmation is necessary. We present the case of a 14-month-old boy with diagnosis of large sized lipoblastoma of retroperitoneal localization.
Descritores: Neoplasias Retroperitoneais/patologia
Lipoblastoma/patologia
-Carga Tumoral
Limites: Seres Humanos
Masculino
Lactente
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


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Id: biblio-887407
Autor: Celik, Suleyman U; Besli Celik, Dilara; Yetiskin, Ece; Ergun, Ergun; Percinel, Sibel; Demirer, Seher.
Título: Fibroadenoma gigante juvenil de mama: presentación de un caso clínico / Giant juvenile fibroadenoma of the breast: a clinical case
Fonte: Arch. argent. pediatr;115(6):428-431, dic. 2017. ilus, tab.
Idioma: en; es.
Resumo: El fibroadenoma gigante juvenil es un tumor de mama benigno y una variante rara de los fibroadenomas. La presentación clínica suele ser una masa tumoral indolora en la mama, aislada y unilateral. Representa entre el 0, 5% y el 2% de todos los fibroadenomas y se desconoce su etiología precisa. Sin embargo, se cree que las hormonas son factores contribuyentes. En este artículo presentamos el caso de un fibroadenoma gigante juvenil de 20 cm de diámetro en la mama de una niña de 14 años. La paciente tenía una masa tumoral indolora, que se había agrandado progresivamente durante 1 año. La ecografía reveló la presencia de un fibroadenoma y se realizó una excisión quirúrgica. Tras diez meses de seguimiento, la paciente se encuentra bien.

Juvenile giant fibroadenoma is a benign breast tumor and rare variant of the fibroadenomas. Clinical presentation is usually a painless, solitary and unilateral breast mass. It accounts for 0.5%-2% of all fibroadenomas and exact etiology is not known; however, hormonal influences are thought to be contributing factors. We present a case of a 20 cm diameter giant juvenile fibroadenoma of the breast in a 14-year-old girl. The patient was suffering from a painless, progressively enlarging mass for 1 year. Ultrasound revealed fibroadenoma and total surgical excision was performed. The patient is doing well in ten months of follow up.
Descritores: Neoplasias da Mama/patologia
Fibroadenoma/patologia
Carga Tumoral
-Fotografia
Limites: Seres Humanos
Feminino
Adolescente
Tipo de Publ: Relatos de Casos
Responsável: AR94.1 - Centro de Información Pediatrica


  6 / 101 LILACS  
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Id: lil-781425
Autor: Li, Hang; Chen, Xiao-li; Li, Jun-ru; Li, Zhen-lin; Chen, Tian-wu; Pu, Hong; Yin, Long-lin; Xu, Guo-hui; Li, Zhen-wen; Reng, Jing; Zhou, Peng; Cheng, Zhu-zhong; Cao, Ying.
Título: Tumor volume of resectable gastric adenocarcinoma on multidetector computed tomography: association with N categories
Fonte: Clinics;71(4):199-204, Apr. 2016. tab, graf.
Idioma: en.
Projeto: Huimin Project of Science and Technology of Chengdu.
Resumo: OBJECTIVE: To determine whether the gross tumor volume of resectable gastric adenocarcinoma on multidetector computed tomography could predict the presence of regional lymph node metastasis and could determine N categories. MATERIALS AND METHODS: A total of 202 consecutive patients with gastric adenocarcinoma who had undergone gastrectomy 1 week after contrast-enhanced multidetector computed tomography were retrospectively identified. The gross tumor volume was evaluated on multidetector computed tomography images. Univariate and multivariate analyses were performed to determine whether the gross tumor volume could predict regional lymph node metastasis, and the Mann-Whitney U test was performed to compare the gross tumor volume among N categories. Additionally, a receiver operating characteristic analysis was performed to identify the accuracy of the gross tumor volume in differentiating N categories. RESULTS: The gross tumor volume could predict regional lymph node metastasis (p<0.0001) in the univariate analysis, and the multivariate analyses indicated that the gross tumor volume was an independent risk factor for regional lymph node metastasis (p=0.005, odds ratio=1.364). The Mann-Whitney U test showed that the gross tumor volume could distinguish N0 from the N1-N3 categories, N0-N1 from N2-N3, and N0-N2 from N3 (all p<0.0001). In the T1-T4a categories, the gross tumor volume could differentiate N0 from the N1-N3 categories (cutoff, 12.3 cm3), N0-N1 from N2-N3 (cutoff, 16.6 cm3), and N0-N2 from N3 (cutoff, 24.6 cm3). In the T4a category, the gross tumor volume could differentiate N0 from the N1-N3 categories (cutoff, 15.8 cm3), N0-N1 from N2-N3 (cutoff, 17.8 cm3), and N0-N2 from N3 (cutoff, 24 cm3). CONCLUSION: The gross tumor volume of resectable gastric adenocarcinoma on multidetector computed tomography could predict regional lymph node metastasis and N categories.
Descritores: Neoplasias Gástricas/patologia
Adenocarcinoma/secundário
Carga Tumoral
Tomografia Computadorizada Multidetectores/métodos
Linfonodos/diagnóstico por imagem
-Prognóstico
Neoplasias Gástricas/cirurgia
Neoplasias Gástricas/diagnóstico por imagem
Adenocarcinoma/cirurgia
Adenocarcinoma/diagnóstico por imagem
Variações Dependentes do Observador
Análise Multivariada
Estudos Retrospectivos
Curva ROC
Neoplasias Epiteliais e Glandulares/patologia
Linfonodos/patologia
Metástase Linfática
Estadiamento de Neoplasias
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


  7 / 101 LILACS  
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Id: lil-796870
Autor: Chu, Zhi-gang; sheng, Bo; Liu, Meng-qi; Lv, Fa-jin; Li, Qi; Ouyang, Yu.
Título: Differential Diagnosis of Solitary Pulmonary Inflammatory Lesions and Peripheral Lung Cancers with Contrast-enhanced Computed Tomography
Fonte: Clinics;71(10):555-561, Oct. 2016. tab, graf.
Idioma: en.
Projeto: Chongqing Scientific & Technological Support Funds; . National Key Clinical Specialties Construction Program.
Resumo: OBJECTIVES: To clarify differences between solitary pulmonary inflammatory lesions and peripheral lung cancers with contrast-enhanced computed tomography. METHODS: In total, 64 and 132 patients with solitary pulmonary inflammatory masses/nodules and peripheral lung cancers, respectively, were enrolled in this study. Their computed tomographic findings were summarized and compared retrospectively. RESULTS: Compared with the peripheral lung cancers, the inflammatory lesions were located closer to the pleura (p<0.0001). The majority of the inflammatory lesions were patchy and oval-shaped (82.8%), whereas most of the tumors were lobulated (82.6%). Almost all the inflammatory cases were unclear (93.8%), whereas most of the tumors had spiculated margins (72.7%). Computed tomography values were significantly higher for the inflammatory lesions than for the cancers (p<0.0001). More than half of the inflammatory lesions had defined necrosis (59.3%). Furthermore, 49.2% of the cancers enhanced inhomogeneously, but only 24.6% had ill-defined necrosis or cavities. The peripheral zones of 98.4% of the inflammatory lesions and 72.7% of the tumors were unclear, with peripheral scattered patches (92.2%) and beam-shaped opacity (66.7%) being the most common findings, respectively. Adjacent pleural thickening was more frequent for the inflammatory lesions than the cancers (95.3% vs. 21.1%, p<0.0001), whereas pleural indentation was found in 67.4% of the subjects with cancer. In addition, hilar (p=0.034) and mediastinal (p=0.003) lymphadenopathy were more commonly detected in the cancers than in the inflammatory cases. CONCLUSIONS: Contrast-enhanced computed tomography findings for pulmonary inflammatory lesions and peripheral lung cancers were significantly different in many aspects. Developing a comprehensive understanding of these differences is helpful for directing their management.
Descritores: Carcinoma/diagnóstico por imagem
Adenocarcinoma/diagnóstico por imagem
Tomografia Computadorizada por Raios X/métodos
Nódulo Pulmonar Solitário/diagnóstico por imagem
Neoplasias Pulmonares/diagnóstico por imagem
-Pleura/patologia
Pleura/diagnóstico por imagem
Carcinoma/patologia
Adenocarcinoma/patologia
Estudos Retrospectivos
Nódulo Pulmonar Solitário/patologia
Meios de Contraste
Carga Tumoral
Diagnóstico Diferencial
Pulmão/patologia
Pulmão/diagnóstico por imagem
Neoplasias Pulmonares/patologia
Necrose
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


  8 / 101 LILACS  
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Brentani, Maria Mitzi
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Id: biblio-840053
Autor: Carrara, Guilherme Freire Angotti; Scapulatempo-Neto, Cristovam; Abrahão-Machado, Lucas Faria; Brentani, Maria Mitzi; Nunes, João Soares; Folgueira, Maria Aparecida Azevedo Koike; Vieira, René Aloisio da Costa.
Título: Breast-conserving surgery in locally advanced breast cancer submitted to neoadjuvant chemotherapy. Safety and effectiveness based on ipsilateral breast tumor recurrence and long-term follow-up
Fonte: Clinics;72(3):134-142, Mar. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: OBJECTIVE: To evaluate ipsilateral breast tumor recurrence after breast-conserving surgery for locally advanced breast cancer. METHODS: A retrospective observational cohort study was performed in patients with locally advanced breast cancer submitted to breast-conserving surgery after neoadjuvant chemotherapy based on an adriamycin-cyclophosphamide-paclitaxel regimen. We evaluated the clinical, pathologic, immunohistochemistry, and surgical factors that contribute to ipsilateral breast tumor recurrence and locoregional recurrence. A Kaplan-Meier analysis and Cox model were used to evaluate the main factors related to disease-free survival. RESULTS: Of the 449 patients who received neoadjuvant chemotherapy, 98 underwent breast-conserving surgery. The average diameter of the tumors was 5.3 cm, and 87.2% reached a size of up to 3 cm. Moreover, 86.7% were classified as clinical stage III, 74.5% had T3-T4 tumors, 80.5% had N1-N2 axilla, and 89.8% had invasive ductal carcinoma. A pathologic complete response was observed in 27.6% of the tumors, and 100.0% of samples had free margins. The 5-year actuarial overall survival rate was 81.2%, and the mean follow-up was 72.8 months. The rates of ipsilateral breast tumor recurrence and locoregional recurrence were 11.2% and 15.3%, respectively. Multifocal morphology response was the only factor related to ipsilateral breast tumor recurrence disease-free survival (p=0.04). A multivariate analysis showed that the pathologic response evaluation criteria in solid tumors (RECIST)-breast cutoff was the only factor related to locoregional recurrence disease-free survival (p=0.01). CONCLUSIONS: Breast-conserving surgery is a safe and effective therapy for selected locally advanced breast tumors.
Descritores: Neoplasias da Mama/cirurgia
Neoplasias da Mama/tratamento farmacológico
Carcinoma/cirurgia
Carcinoma/tratamento farmacológico
Mastectomia Segmentar
Terapia Neoadjuvante/métodos
Recidiva Local de Neoplasia/etiologia
-Fatores de Tempo
Neoplasias da Mama/patologia
Carcinoma/patologia
Análise de Sobrevida
Reprodutibilidade dos Testes
Estudos Retrospectivos
Fatores de Risco
Seguimentos
Resultado do Tratamento
Medição de Risco
Carga Tumoral
Limites: Seres Humanos
Feminino
Adulto
Meia-Idade
Responsável: BR1.1 - BIREME


  9 / 101 LILACS  
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Rados, Pantelis Varvaki
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Id: biblio-893624
Autor: CORTEGOSO, Aurita Veronica Beovide; LAUREANO, Natalia Koerich; SILVA, Alessandra Dutra da; DANILEVICZ, Chris Krebs; MAGNUSSON, Alessandra Sellinger; VISIOLI, Fernanda; RADOS, Pantelis Varvaki.
Título: Cell proliferation markers at the invasive tumor front of oral squamous cell carcinoma: comparative analysis in relation to clinicopathological parameters of patients
Fonte: J. appl. oral sci;25(3):318-323, May-June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Objectives To evaluate the number of AgNORs per nucleus and the expression of Ki-67 at the tumor invasion front (TIF) in relation to clinical parameters (TNM), TIF classification and the prognosis of oral squamous cell carcinomas in an Uruguayan population. Material and Methods This study was conducted through a retrospective survey from 2000 to 2010 at the National Institute of Cancer Montevideo, Uruguay and included 40 patients. The samples were obtained from the resection of the tumor and the TIF was defined according with Bryne, et al.5 (1992). Expression of Ki-67 was assessed by the percentage of positive tumor cells and the AgNOR was recorded as the mean AgNOR (mAgNOR) and the percentage of AgNOR per nucleus (pAgNOR). All analyzes were performed by a blinded and calibrated observer. Results No statistically significant association was observed between immunostaining of Ki-67 and AgNOR with the different types of TIF, regional metastasis and patients prognosis, however it was observed an increase in Ki-67 expression associated with worse patient's clinical staging, although not statistically significant. Conclusions Our results suggest that proliferation markers as AgNOR and Ki-67 are not prognostic markers at the tumor invasive front of carcinoma of oral squamous cell.
Descritores: Antígenos Nucleares/análise
Carcinoma de Células Escamosas/patologia
Neoplasias Bucais/patologia
-Análise de Variância
Biomarcadores Tumorais
Proliferação Celular
Imuno-Histoquímica
Antígeno Ki-67/análise
Invasividade Neoplásica/patologia
Prognóstico
Valores de Referência
Reprodutibilidade dos Testes
Estudos Retrospectivos
Carga Tumoral
Uruguai
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


  10 / 101 LILACS  
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Baracat, Edmund Chada
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Id: biblio-890682
Autor: Peregrino, Pedro Felipe Magalhães; de Lorenzo Messina, Marcos; dos Santos Simões, Ricardo; Soares-Júnior, José Maria; Baracat, Edmund Chada.
Título: Review of magnetic resonance-guided focused ultrasound in the treatment of uterine fibroids
Fonte: Clinics;72(10):637-641, Oct. 2017. tab, graf.
Idioma: en.
Resumo: Uterine leiomyoma is the most frequently occurring solid pelvic tumor in women during the reproductive period. Magnetic resonance-guided high-intensity focused ultrasound is a promising technique for decreasing menorrhagia and dysmenorrhea in symptomatic women. The aim of this study is to review the role of Magnetic resonance-guided high-intensity focused ultrasound in the treatment of uterine fibroids in symptomatic patients. We performed a review of the MEDLINE and Cochrane databases up to April 2016. The analysis and data collection were performed using the following keywords: Leiomyoma, High-Intensity Focused Ultrasound Ablation, Ultrasonography, Magnetic Resonance Imaging, Menorrhagia. Two reviewers independently performed a quality assessment; when there was a disagreement, a third reviewer was consulted. Nineteen studies of Magnetic resonance-guided high-intensity focused ultrasound-treated fibroid patients were selected. The data indicated that tumor size was reduced and that symptoms were improved after treatment. There were few adverse effects, and they were not severe. Some studies have reported that in some cases, additional sessions of Magnetic resonance-guided high-intensity focused ultrasound or other interventions, such as myomectomy, uterine artery embolization or even hysterectomy, were necessary. This review suggests that Magnetic resonance-guided high-intensity focused ultrasound is a safe and effective technique. However, additional evidence from future studies will be required before the technique can be recommended as an alternative treatment for fibroids.
Descritores: Ablação por Ultrassom Focalizado de Alta Intensidade/métodos
Leiomioma/cirurgia
Imagem por Ressonância Magnética Intervencionista/métodos
Neoplasias Uterinas/cirurgia
-Histerectomia/métodos
Leiomioma/diagnóstico por imagem
Leiomioma/patologia
Qualidade de Vida
Resultado do Tratamento
Carga Tumoral
Neoplasias Uterinas/diagnóstico por imagem
Neoplasias Uterinas/patologia
Limites: Seres Humanos
Feminino
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME



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