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Id: biblio-891372
Autor: Kim, Yeon Jung; Moura, Luciana Martins de; Caldas, Christiane Peres; Perozini, Caroline; Ruivo, Gilson Fernandes; Pallos, Debora.
Título: Evaluation of periodontal condition and risk in patients with chronic kidney disease on hemodialysis / Avaliação da condição e risco periodontal em pacientes com doença renal crônica em hemodiálise
Fonte: Einstein (Säo Paulo);15(2):173-177, Apr.-June 2017. tab.
Idioma: en.
Projeto: Fundação de Amparo a Pesquisa de Estado de São Paulo; . Fundação de Amparo a Pesquisa de Estado de São Paulo.
Resumo: ABSTRACT Objective To establish a profile of periodontal conditions in chronic kidney disease patients on hemodialysis and their periodontal risk. Methods We included 115 patients on hemodialysis. Clinical periodontal parameters assessed were: plaque index, gingival index, probing depth and clinical attachment level. Patients were classified according to presence/absence and severity of periodontal disease and periodontal risk. Results In 107 dentate patients (93%) the plaque index was 1.53±0.78, the gingival index was 0.95±0.85, the probing depth was 2.2±0.6mm and the clinical attachment level was 3.18±1.75mm. We observed that 1 patient (0.94%) did not have periodontal disease, 55 patients (51.40%) had slight, 28 (26.17%) moderate and 23 (21.49%) severe periodontal disease. Among 107 patients, 37 (34.58%) had low risk, 35 (32.71%) moderate risk and 35 (32.71%) high risk. Patients with severe periodontal disease showed 104.5 more chance of high risk compared with low risk individuals (odds ratio: 104.5; 95%CI: 10.7-1017.2; p<0.0001). Conclusion Most of patients with chronic renal disease presented periodontal disease, indicating the presence of chronic inflammatory and infection process that may influence in systemic conditions. A prevention and interventionist approach in this population is needed, especially to emphasize the importance of oral health. The periodontal risk assessment is a useful tool to create individualized periodontal therapies and to improve general health condition.

RESUMO Objetivo Traçar um perfil das condições periodontais de pacientes com doença renal crônica em hemodiálise e seu risco periodontal. Métodos Foram incluídos no estudo 115 pacientes em hemodiálise. Os parâmetros clínicos periodontais avaliados foram: índice de placa, índice gengival, profundidade de sondagem e perda de nível de inserção clínico. Os pacientes foram classificados de acordo com a presença e a gravidade da doença periodontal, bem como de acordo com o risco periodontal. Resultados Quanto aos parâmetros clínicos, 107 pacientes dentados (93%) apresentaram média de índice de placa de 1,53±0,78 e gengival de 0,95±0,85, profundidade de sondagem de 2,2±0,6mm e nível de inserção clínica de 3,18±1,75mm. Em relação à doença periodontal, 1 (0,94%) era saudável, 55 (51,40%) apresentavam periodontite leve, 28 (26,17%) moderada e 23 (21,49%) avançada. Com relação ao risco, dos 107 pacientes, 37 apresentavam risco baixo, 35 moderado e 35 alto. Os pacientes com doença periodontal avançada apresentaram 104,5 vezes mais chance de ter alto risco comparado ao baixo (odds ratio: 104,5; IC95%: 10,7-1017,2; p<0,0001). Conclusão A maioria dos pacientes com doença renal crônica apresentou doença periodontal, indicando um processo infeccioso e inflamatório crônico, que pode influenciar na condição sistêmica. Evidencia-se a necessidade de uma abordagem preventiva e intervencionista nesta população, enfatizando a importância da saúde bucal. A avaliação do risco periodontal seria uma ferramenta na elaboração de terapias periodontais individualizadas para uma melhor condição de saúde geral.
Descritores: Doenças Periodontais/complicações
Diálise Renal/efeitos adversos
Medição de Risco
Insuficiência Renal Crônica/complicações
-Doenças Periodontais/diagnóstico
Índice de Gravidade de Doença
Índice Periodontal
Índice de Placa Dentária
Estudos Transversais
Perda da Inserção Periodontal/diagnóstico
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-794516
Autor: Giacaman, Rodrigo A; Sandoval Salas, Dalila; Bustos Alvarez, Ivonne P; Rojas Cáceres, Miguel A; Mariño, Rodrigo J.
Título: Epidemiología del estado de salud periodontal en la VII Región del Maule, Chile / Epidemiology of periodontal status in the Maule Region, Chile
Fonte: Rev. clín. periodoncia implantol. rehabil. oral (Impr.);9(2):184-192, ago. 2016. tab.
Idioma: es.
Projeto: International Association for Dental Research (IADR); . Universidad de Talca. Regional Development Program for Training in Research methods and oral health surveys and the assessment of oral health in the chilean division of the IADR.
Resumo: Antecedentes Pese a que la enfermedad periodontal es una patología altamente prevalente, en Chile la información regional es escasa y limitada, especialmente en lo referente a la realidad de la población rural. Objetivo Dada la falta de datos locales y el alto índice de ruralidad de la Región del Maule, el objetivo de este estudio fue determinar el estado periodontal de la población de 6, 12, 15, 35 a 44 y 65 a 74 años que vive en la Región del Maule. Metodología Se llevó a cabo un estudio transversal (EpiMaule) con 2.414 personas, agrupadas según las edades de vigilancia epidemiológica señaladas por la Organización Mundial de la Salud (OMS) para estudios poblacionales, sexo y zona de procedencia. Se midió el índice de placa bacteriana de Silness y Löe (IP), el índice gingival de Löe y Silness (IG) y el índice periodontal comunitario (IPC). Se analizaron los datos mediante estadística descriptiva y analítica con un nivel de significancia del 5%. Resultados La gran mayoría de la población presentó niveles moderados de placa bacteriana y de inflamación gingival, tanto los niños como los adultos y los adultos mayores. Los adolescentes de 15 años mostraron la mayor prevalencia de sangramiento al sondaje en todas las edades examinadas. Los adultos mayores mostraron los valores más altos de IP (1,75) e IG (1,62) entre todos los grupos estudiados, afectando mayormente a los mayores que viven en zonas rurales. Los hombres y la población rural presentan los valores más altos para el IP como para el IG (p < 0,05). Con un 77,2% de la población de 35 a 44 años, el código 2 del IPC fue el más frecuentemente detectado. Por su parte, el 28,8% de los participantes de 65-74 años tenían profundidades al sondaje ≥ 4 mm, representando el grupo etario con mayor prevalencia de este nivel de IPC (p < 0,05). Conclusiones La población de la Región del Maule presenta importantes diferencias en el estado periodontal según edad, sexo y ruralidad, siendo los más afectados los adultos mayores. Estos datos sugieren la necesidad de implementar políticas de salud bucal que aborden diferencialmente las distintas necesidades de las personas.

Background Despite periodontal disease being highly prevalent in Chile, information from the regions is scarce and limited, particular as regards the situation in the rural population. Objective Given the lack of local data and the high rurality index of the Maule Region, the aim of this study was to determine the periodontal status of the 6, 12, 15, 35 to 44, and 65 to 74 year-old population that lives in the Region. Methodology A cross-sectional study (EpiMaule) was conducted on 2,414 individuals, grouped according to the epidemiological surveillance ages indicated by the World Health Organisation (WHO) for population studies, sex and area of study. The measurements made include the Silness-Löe bacterial plaque index (IP), Silness-Löe gingival index (IG), and the community periodontal index (IPC). The data were analysed using descriptive and analytical statistics with a significance level of 5%. Results The large majority of the population, including children, adults and the elderly, had moderate levels of bacterial plaque and gingival inflammation. Adolescents of 15 years showed the highest prevalence of bleeding on probing in all the ages examined. The older adults had the highest IP (1.75) and IG values among all the groups studied, mainly affecting the older ones that lived in rural areas. Males and the rural population had the highest values for IP as well as for IG (P < .05). A CPI level of 2 was most frequently detected in 77.2% of the 35 to 44 years population. On the other hand, more than one-quarter (28.8%) of the 65-74 year-old participant had probe depths ≥ 4 mm, being the age group with a high prevalence at this CPI level (P < .05). Conclusions The population of the Maule Region show significant differences in periodontal status, according to age, sex, and rurality, with the elderly being the most affected. These data suggest the need to implement oral health policies that differentially approach the individual needs of the population.
Descritores: Doenças Periodontais/epidemiologia
Saúde Bucal/estatística & dados numéricos
-Chile/epidemiologia
Índice Periodontal
Índice de Placa Dentária
Nível de Saúde
Estudos Transversais
Fatores Etários
Distribuição por Idade
Placa Dentária/epidemiologia
Limites: Seres Humanos
Masculino
Feminino
Criança
Adolescente
Adulto
Meia-Idade
Idoso
Responsável: CL58.1 - Biblioteca


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Id: lil-792599
Autor: KAMPITS, Cassio; MONTENEGRO, Marlon M; RIBEIRO, Ingrid WJ; FURTADO, Mariana V; POLANCZYK, Carisi A; RÖSING, Cassiano K; HAAS, Alex. N.
Título: Periodontal disease and inflammatory blood cytokines in patients with stable coronary artery disease
Fonte: J. appl. oral sci;24(4):352-358, July-Aug. 2016. tab.
Idioma: en.
Projeto: National Council for Scientific and Technological Development.
Resumo: ABSTRACT Periodontal disease has been associated with elevations of blood cytokines involved in atherosclerosis in systemically healthy individuals, but little is known about this association in stable cardiovascular patients. The aim of this study was to assess the association between periodontal disease (exposure) and blood cytokine levels (outcomes) in a target population of patients with stable coronary artery disease (CAD). Material and Methods This cross-sectional study included 91 patients with stable CAD who had been under optimized cardiovascular care. Blood levels of IL-1β, IL-6, IL-8, IL-10, IFN-γ, and TNF-α were measured by Luminex technology. A full-mouth periodontal examination was conducted to record probing depth (PD) and clinical attachment (CA) loss. Multiple linear regression models, adjusting for gender, body mass index, oral hypoglycemic drugs, smoking, and occurre:nce of acute myocardial infarction were applied. Results CAD patients that experienced major events had higher concentrations of IFN-γ (median: 5.05 pg/mL vs. 3.01 pg/mL; p=0.01), IL-10 (median: 2.33 pg/mL vs. 1.01 pg/mL; p=0.03), and TNF-α (median: 9.17 pg/mL vs. 7.47 pg/mL; p=0.02). Higher numbers of teeth with at least 6 mm of CA loss (R2=0.07) and PD (R2=0.06) were significantly associated with higher IFN-γ log concentrations. Mean CA loss (R2=0.05) and PD (R2=0.06) were significantly related to IL-10 concentrations. Elevated concentrations of TNF-α were associated with higher mean CA loss (R2=0.07). Conclusion Periodontal disease is associated with increased systemic inflammation in stable cardiovascular patients. These findings provide additional evidence supporting the idea that periodontal disease can be a prognostic factor in cardiovascular patients.
Descritores: Doenças Periodontais/sangue
Doença da Artéria Coronariana/sangue
Interleucinas/sangue
Interferon gama/sangue
Fator de Necrose Tumoral alfa/sangue
-Doenças Periodontais/fisiopatologia
Valores de Referência
Doença da Artéria Coronariana/fisiopatologia
Biomarcadores/sangue
Fumar/efeitos adversos
Modelos Lineares
Índice Periodontal
Estudos Transversais
Valor Preditivo dos Testes
Inquéritos e Questionários
Fatores de Risco
Perda da Inserção Periodontal
Limites: Seres Humanos
Masculino
Feminino
Meia-Idade
Idoso
Responsável: BR1.1 - BIREME


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Id: lil-787542
Autor: PATARO, André Luiz; CORTELLI, Sheila Cavalca; ABREU, Mauro Henrique Nogueira Guimarães; CORTELLI, José Roberto; FRANCO, Gilson Cesar Nobre; AQUINO, Davi Romeiro; COTA, Luis Otavio Miranda; COSTA, Fernando Oliveira.
Título: Frequency of periodontal pathogens and Helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study
Fonte: J. appl. oral sci;24(3):229-238tab.
Idioma: en.
Projeto: Minas Gerais Research Foundation; . São Paulo Research Foundation.
Resumo: ABSTRACT Objectives This cross-sectional study compared the frequency of oral periodontopathogens and H. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery. Material and Methods One hundred and fifty-four men and women aged 18-65 were conveniently distributed into four groups. Two groups were composed of individuals who underwent bariatric surgery with (BP) (n=40) and without (BNP) (n=39) periodontitis and two obese control groups with (CP) (n=35) and without (CNP) (n=40) periodontitis. The oral pathogens Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Parvimonas micra, Treponema denticola, Tannerella forsythia, Campylobacter rectus, and Helicobacter pylori were detected by a polymerase chain reaction technique using saliva, tongue and stomach biopsy samples. Results Statistical analysis demonstrated that periodontopathogens were highly frequent in the mouth (up to 91.4%). In the bariatric surgically treated group, orally, P. gingivalis, T. denticola and T. forsythia were more frequent in periodontitis, while C. rectus was more frequent in non-periodontitis subjects. Stomach biopsies also revealed the high frequency of five oral species in both candidates for bariatric surgery (91.6%) and the bariatric (83.3%) groups. H. pylori was frequently detected in the mouth (50.0%) and stomach (83.3%). In the stomach, oral species and H. pylori appeared in lower frequency in the bariatric group. Conclusions Obese individuals showed high frequencies of periodontopathogens and H. pylori in their mouths and stomachs. Bariatric surgery showed an inverse microbial effect on oral and stomach environments by revealing higher oral and lower stomach bacterial frequencies.
Descritores: Estômago/microbiologia
Bactérias/isolamento & purificação
Helicobacter pylori/isolamento & purificação
Cirurgia Bariátrica
Boca/microbiologia
Obesidade/microbiologia
-Periodontite/microbiologia
Valores de Referência
Saliva/microbiologia
Biópsia
Índice de Massa Corporal
Índice Periodontal
Reação em Cadeia da Polimerase
Estudos Transversais
Análise de Variância
Estatísticas não Paramétricas
Placa Dentária/microbiologia
Obesidade/cirurgia
Limites: Seres Humanos
Masculino
Feminino
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-889467
Autor: Musskopf, Marta Liliana; Milanesi, Fernanda Carpes; Rocha, José Mariano da; Fiorini, Tiago; Moreira, Carlos Heitor Cunha; Susin, Cristiano; Rösing, Cassiano Kuchenbecker; Weidlich, Patricia; Oppermann, Rui Vicente.
Título: Oral health related quality of life among pregnant women: a randomized controlled trial
Fonte: Braz. oral res. (Online);32:e002, 2018. tab, graf.
Idioma: en.
Projeto: National Council of Research.
Resumo: Abstract: The aim of the present study was to compare negative impacts of oral conditions in Oral Heath Related Quality of Life (OHRQoL) assessed by the Oral Health Impact Profile-14 (OHIP-14) scores in pregnant women receiving or not comprehensive periodontal treatment. This randomized controlled clinical trial included pregnant women aged between 18 and 35 years old. Participants were randomized in a test group with 96 and a control group with 114 women. Patients in the test group received comprehensive periodontal treatment, supra and subgingival scaling and root-planning and periodontal maintenance appointments. The OHIP-14 was applied before and after treatment. The primary outcome was changes in OHIP-14 scores after follow-up period. The impact of having received or not comprehensive periodontal treatment on the change of the OHIP-14 scores was also investigated. Both groups showed significant reduction in OHIP-14 scores and effect size for the test group was 0.60 and 0.36 for the control group. Multinomial logistic regression analysis showed that participants of the control group had 5.9-fold odds (CI 95% 1.88-18.52) of worsening in OHIP-14 scores and their perception of oral conditions in relation to test group. Comprehensive periodontal treatment during pregnancy can reduce the negative impacts in OHRQoL.
Descritores: Doenças Periodontais/terapia
Complicações na Gravidez/terapia
Qualidade de Vida
Saúde Bucal/estatística & dados numéricos
-Cuidado Pré-Natal
Fatores Socioeconômicos
Modelos Logísticos
Índice Periodontal
Índice de Placa Dentária
Nível de Saúde
Inquéritos e Questionários
Resultado do Tratamento
Perfil de Impacto da Doença
Limites: Seres Humanos
Feminino
Gravidez
Adulto
Adulto Jovem
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: biblio-839530
Autor: FUKUSHIMA, Henrique; ALVES, Vanessa Tubero Euzebio; CARVALHO, Verônica Franco de; AMBRÓSIO, Lucas Macedo Batitucci; EICHLER, Rosangela Aparecida dos Santos; CARVALHO, Maria Helena Catelli de; SARAIVA, Luciana; HOLZHAUSEN, Marinella.
Título: PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity
Fonte: Braz. oral res. (Online);31:e16, 2017. tab, graf.
Idioma: en.
Projeto: Sao Paulo State Research Foundation.
Resumo: Abstract Recent studies investigating protease-activated receptor type 2 (PAR-2) suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF) of patients with moderate chronic periodontitis (MP). The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19) at baseline, and from MP patients (n = 19) and severe chronic periodontitis (SP) (n = 19) patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA) in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR). PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p <0.05) PAR-2 expression in patients with periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.
Descritores: Líquido do Sulco Gengival/química
Receptor PAR-2/análise
Periodontite Crônica/patologia
-Valores de Referência
Índice de Gravidade de Doença
Cisteína Endopeptidases/análise
Biomarcadores/análise
Estudos de Casos e Controles
Expressão Gênica
Índice Periodontal
Índice de Placa Dentária
Perda da Inserção Periodontal
Porphyromonas gingivalis
Estatísticas não Paramétricas
Adesinas Bacterianas/análise
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-839515
Autor: SEZGIN, Yasemin; URAZ, Ahu; TANER, I. Levent; ÇULHAOĞLU, Rana.
Título: Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral
Fonte: Braz. oral res. (Online);31:e15, 2017. tab, graf.
Idioma: en.
Projeto: Gazi University.
Resumo: Abstract Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intra-bony defects. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with a simplified technique. Although certain studies have reported the use of PRF in the treatment of intra-bony defects, to date, none of them have evaluated its additive effects with ABBM. Therefore, a randomised, split-mouth clinical trial was conducted to compare healing of intra-bony defects treated with an ABBM-PRF combination with healing of those treated with ABBM alone. By using a split-mouth design, 15 paired intra-bony defects were randomly treated with either ABBM alone (control group) or ABBM-PRF combination (test group). Following clinical parameters and radiographical measurements were recorded at baseline and 6 months after treatment: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, depth of defect and defect angle. Preoperative clinical and radiographical measurements were similar for the test and control groups. Statistically significant reductions in GI, PD, CAL, vertical bone loss, depth of intra-bony defect and widening of defect angle were detected after treatment in both groups. With respect to inter-group analysis, gain in CAL was significantly greater in the test group than in the control group, whereas no inter-group differences were observed in any other parameter. The results of this study indicate that both therapies are effective in the treatment of intra-bony defects.
Descritores: Cicatrização/efeitos dos fármacos
Plaquetas
Regeneração Óssea/efeitos dos fármacos
Fibrina/uso terapêutico
Perda do Osso Alveolar/terapia
Substitutos Ósseos/uso terapêutico
-Fatores de Tempo
Índice Periodontal
Índice de Placa Dentária
Reprodutibilidade dos Testes
Perda do Osso Alveolar/diagnóstico por imagem
Resultado do Tratamento
Terapia Combinada
Estatísticas não Paramétricas
Retração Gengival
Limites: Seres Humanos
Animais
Masculino
Feminino
Adulto
Bovinos
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: BR1.1 - BIREME


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Id: lil-778894
Autor: Sarduy Bermúdez, Lázaro; González Díaz, María Elena; Corrales Álvarez, Mitdrey; Barreto Fiu, Eligio Eduardo; Rodríguez Labrada, Magdiel.
Título: Estado periodontal y su posible relación con variables funcionales de la oclusión / Periodontal state and its possible relationship to functional occlusal variables
Fonte: Medicentro (Villa Clara);20(2):95-103, abr.-jun. 2016.
Idioma: es.
Resumo: Entre noviembre del 2010 y septiembre del 2011 se realizó un estudio descriptivo transversal para caracterizar la posible relación del factor oclusal con el estado periodontal de pacientes atendidos en el servicio de Periodoncia de la Clínica Estomatológica «Victoria de Santa Clara¼. Constituyeron unidades de análisis 40 pacientes y 1 112 dientes. Se determinó el estado periodontal al aplicar los índices periodontal de Russell y de movilidad de Miller, la medición de la profundidad de las bolsas periodontales y la presencia o no de pérdidas óseas. Se estudiaron variables oclusales funcionales seleccionadas. No se obtuvo correlación entre la profundidad de las bolsas y las alteraciones funcionales oclusales, excepto en el contacto exagerado. Las pérdidas angulares presentaron mayor profundidad de bolsas. La distribución de los dientes afectados en su función oclusal, según los códigos del índice periodontal, no siguió una tendencia única. La mayoría de los dientes con alteraciones funcionales presentaron movilidad dentaria.
Descritores: Bolsa Periodontal
Índice Periodontal
Má Oclusão
Responsável: CU425.1 - Centro Provincial de Información de Ciencias Médicas de Villa Clara


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Id: biblio-1026675
Autor: Bulgakova, Albina Irekovna; Vasilyeva, Nadezhda Aleksandrovna; Vasilyev, Eduard Aleksandrovich.
Título: Immunological and Morphological substantiation of the use of dental stick with biopharmaceuticals in the complex therapy of inflammatory periodontal diseases
Fonte: Prensa méd. argent;105(4):157-164, jun 2019. tab.
Idioma: en.
Resumo: Aim of the study: clinical, immunological and morphological substantiation of the use of a dental stick with biopharmaceuticals in the complex therapy of inflammatory periodontal diseases. Research methods: leukocyte migration test, cytograms, the study of quantitative and qualitative content of spontaneously released mixed saliva, measurement of the total content of protein, the content of secretory immunoglobulin A (sIgA) and lysozyme in it. Clinical improvement of the periodontal tissues condition after treatment by 77% was registered. OHI-S (hygienic index), PI (periodontal disease index), PMA (papillary-marginal-alveolar index) were 7.5, 3.4, and 8.7 times lower, respectively, compared to the pre-treatment group. The depth of periodontal pockets decreased 2.6-3.4 times, the number of sessions per treatment course was reduced to 3-8 visits to the doctor. The amount of mixed saliva (in comparison with the initial data) increased 2.7 times, normal levels were restored and were 1.2 ml higher than control indicators. Protein levels, lysozyme and sIgA concentrations increased and exceeded the pre-treatment level 1.8 times and by 44.5%, respectively. Cytograms data revealed that the number of red blood cells (in one field of view) in the gingiva specimens in inflammatory periodontal diseases (IPD) patients was 2.3 times lower, count of leukocytes with signs of destruction was 13.4 lower and intact leukocyte count was 3.8 times lower. Lymphocyte count was 2 times lower, indicating that the inflammatory process in periodontal tissues was reduced as a re sult of the reduction of the microbial burden: staphylococci and actinomycetes were detected 3 times less often, diplococci ­ 3.5 times less often, filamentous bacteria and streptococci ­ 4 times less often, protists ­ 5 times less often, respectively. The number of cocci microcolonies was 2.7 times higher. The number of fibroblasts (in one field of view) increased threefold, the content of collagen filaments of the normally oriented structure increased 1.4 times, compared to the original data, which indicated the formation of favorable conditions for healing and reparative regeneration processes. The results of the study showed that the use of a dental stick during local IPD therapy is an effective way of correcting changes in clinical and laboratory indicators of local immunity and that dental stick is a promising new dosage form in practical periodontology.
Descritores: Doenças Periodontais/terapia
Contenções Periodontais
Saliva/imunologia
Produtos Biológicos/uso terapêutico
Implantes Dentários
Movimento Celular
Índice Periodontal
Indicadores (Estatística)
Limites: Seres Humanos
Responsável: AR392.1 - Biblioteca


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Id: biblio-1023146
Autor: Beiler, Tatiane Flôr Coelho de Souza Breves.
Título: Impacto do tratamento periodontal não cirúrgico nos níveis de biomarcadores do metabolismo ósseo na saliva / Non-surgical periodontal treatment impact on biomarkers levels of bone metabolism in saliva.
Fonte: Rio de janeiro; s.n; 2019. 85 p. ilus.
Idioma: pt.
Tese: Apresentada a Universidade do Estado do Rio de Janeiro. Faculdade de Odontologia para obtenção do grau de Doutor.
Resumo: O objetivo foi avaliar o efeito do tratamento periodontal não cirúrgico, após 1 ano, na expressão salivar dos marcadores do metabolismo ósseo: TNF-α, SOST, PTH, OPG, OPN, OC, Leptina, IL-6, IL-1ß e FGF-23; em pacientes com periodontite crônica generalizada. Participaram deste estudo 15 pacientes com periodontite crônica generalizada (idade média 56,0  DP 9,6 anos). Quinze pacientes com gengivite (idade média 39,7  DP 4,4 anos) foram utilizados como controles. Foram utilizados os seguintes parâmetros clínicos: profundidade de bolsa à sondagem (PBS); nível de inserção clínica (NIC); índice de placa visível (IPV); índice de sangramento gengival (ISG) e índice de sangramento à sondagem (ISS). Foi realizada a coleta de saliva não estimulada (1ml) e congelada à -70°C para posterior análise. Os pacientes de ambos os grupos receberam tratamento periodontal não cirúrgico. Todos os dados foram coletados em 3 visitas no grupo com periodontite (baseline, 6 meses e 1 ano); e em 2 visitas no grupo com gengivite (baseline e 1 ano). Os biomarcadores foram mensurados por meio de um imunoensaio multiplex. No grupo com periodontite, houve redução significativa dos parâmetros % PBS ≥ 6 (p<0,001) e % NIC ≥ 5 (p<0,001), nas visitas 6 meses e 1 ano. Para os dados clínicos do grupo com gengivite, houve diminuição significativa após 1 ano para: % placa (p=0,001), % sangramento marginal (p=0,001), % sangramento sondagem (p=0,001), PBS (média pac.) (p=0,020) e NIC (média pac.) (p=0,001). Após o tratamento no grupo com periodontite, observou-se redução significativa da IL-1ß, IL-6, Leptina e TNF-α, entre a visita baseline e 6 meses (p=0,006; p=0,050; p=0,047; p= 0,014; respectivamente). Entre o baseline e 1 ano, houve diferença significante para a IL-1ß (p=0,010) e OPG (p=0,050). Já a IL-6 e OPG, mostraram uma tendência a redução após 1 ano (p=0,074; p=0,063; respectivamente). No grupo com gengivite, não foram observadas diferenças significativas entre as visitas baseline e 1 ano para todos os biomarcadores. No grupo com periodontite, na visita 1 ano, observamos correlação negativa significativa da OPG com % sangramento sondagem ( τ-b = -0,524 / p=0,006); no grupo com gengivite, na visita baseline, observamos correlação positiva significativa da IL-6 com % placa (τ-b= 0,548 / p= 0,005). Já na visita 1 ano, a Leptina passou a se correlacionar de forma mais forte com % placa (τ-b=0,624 / p=0,010) e com % sangramento marginal (τ-b=0,751 / p= 0,001). Concluindo, a terapia periodontal não cirúrgica levou a uma melhora significativa dos parâmetros clínicos periodontais associada à uma redução significante nos níveis de TNF-α, Leptina e IL-1ß; e uma tendência à redução dos biomarcadores OPG e IL-6. Após 1 ano, verificamos que os níveis dos biomarcadores do grupo com periodontite se aproximaram aos valores do grupo com gengivite, sugerindo que o tratamento periodontal foi capaz de equalizar a resposta imunológica.

The aim of this study was to evaluate the effect of non-surgical periodontal therapy, after 1 year, on the salivar expression of bone metabolism markers: TNF-α, SOST, PTH, OPG, OPN, OC, Leptin, IL-6, IL-1ß and FGF-23; in patients with generalized chronic periodontitis. Fifteen patients with generalized chronic periodontitis (mean age 56.0 ± SD 9.6 years) were included in this study. Fifteen patients with gingivitis (mean age 39.7 ± SD 4.4 years) were used as controls. Clinical evaluation parameters including probing pocket depth (PD), clinical attachment level (CAL), visible plaque index (VPI), gingival index bleeding (GI) and bleeding on probing (BOP) were used. Non-stimulated whole saliva was collected (1ml) and frozen at -70°C for further analysis. Patients from both groups received non-surgical periodontal treatment. All data were collected in 3 visits in the group with periodontitis (baseline, 6 months and 1 year); and in 2 visits in the group with gingivitis (baseline and 1 year). The biomarkers expression were evaluated through multiplex technology. In the group with periodontitis, there was a significant reduction of the parameters % PD ≥ 6 (p <0,001) and % CAL ≥ 5 (p <0,001), at 6 months and 1 year visits. For the clinical data of the group with gingivitis, there was a significant decrease after 1 year for: plaque (p=0,001), sulcus bleeding (p=0,001), bleeding on probing (p=0,001), PD (p=0,020) and CAL (p=0,001). After treatment in the group with periodontitis, a significant reduction of IL-1ß, IL-6, Leptin and TNF-α was observed between baseline and 6 months visit (p=0,006; p=0,050; p=0,047; p=0,014; respectively). Between baseline and 1 year, there was significant difference for IL-1ß (p=0,010) and OPG (p=0,050). On the other hand, IL-6 and OPG showed a tendency to decrease after 1 year (p=0,074; p=0,063; respectively). In the group with gingivitis, no significant differences were observed between the baseline visits and 1 year for all biomarkers. In the group with periodontitis, at the 1-year visit, we observed a significant negative correlation of OPG with bleeding on probing (τ-b=-0,524 / p=0,006); in the group with gingivitis, at the baseline visit, we observed a significant positive correlation of IL-6 with plaque (τ-b=0,548 / p=0,005). At the 1-year visit, Leptin correlated more strongly with plaque (τ-b=0,624 / p=0,010) and with sulcus bleeding (τ-b=0,751 / p=0,001). In conclusion, non-surgical periodontal therapy led to a significant improvement in periodontal clinical parameters associated with a significant reduction in levels of TNF-α, Leptin and IL-1ß; the OPG and IL-6 showed a tendency to reduce. After 1 year, we observed that the biomarkers levels in the group with periodontitis approximate the values of the group with gingivitis, suggesting that the periodontal treatment was able to equalize the immune response.
Descritores: Saliva/química
Osso e Ossos/metabolismo
Periodontite Crônica/terapia
Gengivite/terapia
-Reabsorção Óssea
Biomarcadores
Índice Periodontal
Citocinas
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Idoso
Responsável: BR1366.1 - Biblioteca Biomédica B - CB/B (Odontologia e Enfermagem)
BR1366.1; 616.314, B422, TO850



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