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Id: biblio-1052966
Autor: Herrera Bornes, María Florencia.
Título: El metilfenidato reduce la apatía en pacientes con Alzheimer / Methylphenidate reduces apathy in patients with Alzheimer's disease
Fonte: Evid. actual. práct. ambul;22(4):e001090, 2019. tab..
Idioma: es.
Descritores: Apatia
Doença de Alzheimer/tratamento farmacológico
Estimulantes do Sistema Nervoso Central/uso terapêutico
Metilfenidato/uso terapêutico
-Veteranos/psicologia
Índice de Gravidade de Doença
Atividades Cotidianas
Ensaios Clínicos Controlados Aleatórios como Assunto
Método Duplo-Cego
Estudos Prospectivos
Cuidadores
Cognição
Depressão/psicologia
Vida Independente
Doença de Alzheimer/fisiopatologia
Doença de Alzheimer/psicologia
Testes de Estado Mental e Demência
Limites: Seres Humanos
Masculino
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central


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Id: biblio-1040167
Autor: Norambuena-Mardones, Leandra; Pinto-Daza, Dominique Evelyn; Troncoso-Fernández, Karla Daniela; Pacheco, Alejandro; Vitzel, Kaio Fernando; Marzuca-Nassr, Gabriel Nasri.
Título: Effectiveness of short-term physical agents treatment on macroscopic morphology in patients with plaque psoriasis / Efectividad del tratamiento a corto plazo de los agentes físicos en la morfología macroscópica de las placas de psoriasis
Fonte: Int. j. morphol;37(4):1541-1550, Dec. 2019. tab, graf.
Idioma: en.
Projeto: Universidad de La Frontera; . FONDECYT.
Resumo: Psoriasis is a chronic inflammatory disease that presents skin rashes which can arise through plaques. The aim of this work was to compare the effectiveness of short-term physical agents treatment on macroscopic morphology (area and erythema) in patients with plaque psoriasis. This prospective randomized experimental study included fourteen subjects, medically diagnosed with psoriasis, with more than one plaque in the skin and voluntarily without topical treatment. All subjects completed the study that consisted of 12 treatment sessions divided in control (C), artificial balneotherapy (AB), phototherapy (PT) or balneophototherapy (BPT) groups. After session 12, there was a significant reduction of the plaque area by all treatments when compared to C group and BPT was the most effective one. However, only AB and PT presented a reduction of erythema. Regarding severity, 9 patients changed to a lower category on the PASI test, and 5 of them maintained a mild psoriasis, but lowered their score. Finally, 13 of 14 subjects improved their quality of life. The physical agents used reduced the severity of psoriasis and improved quality of life of patients after 12 sessions of treatment during a onemonth period. The BPT was the more effective in controlling psoriasis by diminishing its area and PT by attenuating the erythema.

La Psoriasis es una enfermedad inflamatoria crónica que presenta irritación cutánea que puede derivar a placas. El objetivo de este trabajo fue comparar la efectividad del tratamiento a corto plazo con agentes físicos en la morfología macroscópica (área y eritema) en pacientes con placas de psoriasis. Estudio experimental, prospectivo, randomizado. Catorce sujetos participaron con diagnóstico médico de psoriasis, con más de una placa en la piel y sin tener tratamiento tópico de forma voluntaria. Todos los sujetos completaron el estudio, el cual consistió de 12 sesiones de tratamiento dividido en grupo control (C), BA, FT y BFA. Posterior a la sesión 12, se observó una reducción significativa en toda el área de las placas que recibieron tratamiento al compararlas al grupo C y el grupo BFA fue el más efectivo. Sin embargo, solo los grupos BA y FT presentaron una reducción del eritema. Respecto a la severidad, 9 pacientes cambiaron de la baja categoría en el test de PASI y 5 de ellos se mantuvieron en el nivel medio, pero disminuyeron su puntaje. Finalmente, 13 de 14 sujetos mejoraron su calidad de vida. Los agentes físicos usados redujeron la severidad de la psoriasis y mejoraron la calidad de vida de los pacientes después de 12 sesiones de tratamiento durante el período de un mes. La BFA fue la más efectiva en controlar la psoriasis por la disminución en el área y la FT por la atenuación del eritema.
Descritores: Fototerapia/métodos
Psoríase/terapia
Balneologia/métodos
-Psoríase/patologia
Psoríase/psicologia
Qualidade de Vida
Fatores de Tempo
Índice de Gravidade de Doença
Estudos Prospectivos
Inquéritos e Questionários
Resultado do Tratamento
Limites: Seres Humanos
Masculino
Feminino
Adulto
Tipo de Publ: Ensaio Clínico Controlado Aleatório
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-977091
Autor: Roncada, Cristian; Soldera, Karina; Andrade, Julia; Bischoff, Luísa Carolina; Bugança, Bianca Martininghi; Cardoso, Thiago de Araujo; Pitrez, Paulo Márcio.
Título: Avaliação da qualidade de vida de pais e cuidadores de crianças asmáticas / Evaluation of quality of life of parents and caregivers of asthmatic children
Fonte: Rev. Paul. Pediatr. (Ed. Port., Online);36(4):451-456, out.-dez. 2018. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo: Avaliar e comparar os níveis de qualidade de vida (QV) de pais de crianças com e sem diagnóstico médico de asma. Métodos: Foi realizado um estudo com pais e cuidadores de crianças com e sem asma no período de 2015 a 2016. Foram selecionados pais de crianças com asma (grupo asma) em acompanhamento ambulatorial e pais de crianças sem asma ou com asma em remissão (grupo controle) em escolas proximais ao estudo, sendo aplicado um questionário respiratório para classificação da amostra. Para avaliação dos níveis de QV, foi aplicado o instrumento desenvolvido pela Organização Mundial da Saúde (OMS)- The World Health Organization Quality of Life (WHOQOL-BREF), previamente validado para a população em estudo, sendo comparados os domínios físico, psicológico, das relações sociais e do meio ambiente e o escore total, além ter sido realizada correlação entre os níveis de autopercepção da QV e da satisfação com a saúde. Resultados: Participaram do estudo 101 cuidadores de crianças com e sem asma- 50 (49,5%) formaram o grupo asma, e 51 (50,5%), o grupo controle. Amaioria dos genitores é do sexo feminino (n=89; 88,1%), com idade média de 33,5±10,4anos. Naavaliação da QV, o valor do escore total dos domínios foi considerado satisfatório, tanto na avaliação geral (68,6±13,4) quanto por grupos (asma: 62,8±10,7; controle: 74,3±13,4), demonstrando diferenças significativas entre estes em todos domínios estipulados pelo instrumento (p<0,001), bem como no escore total (p<0,001). Conclusões: Cuidadores de crianças com asma possuem QV significativamente inferior à dos responsáveis por crianças saudáveis.

ABSTRACT Objective: To evaluate and compare the levels of quality of life of parents/caregivers of children with and without diagnosis of asthma. Methods: Parents of children with asthma (asthma group) undergoing outpatient care and parents of children without asthma or asthma in remission (control group) were selected from public schools. They answered a questionnaire about quality of life (The World Health Organization Quality of Life- WHOQOL-BREF), previously validated for the study population. Domains (physical, psychological, social relations, environment and total score) were compared between groups, as well as the levels of correlation of self-perceived quality of life and satisfaction with health. Results: 101 parents/caregivers were included in the sample, that is, 50 (49.5%) parents of asthmatic children and 51 (50.5%) in the control group. Most parents included in the sample were females (n=89; 88.1%), with mean age of 33.5±10.4 years. When assessing quality of life, the overall score of domains was considered satisfactory, both in general evaluation (68.6±13.4) and in each group (asthma: 62.8±10.7; control: 74.3±13.4; p-value<0.001). Comparison of asthma and control groups showed significant differences in total score and in scores of all domains (p<0.001). Conclusions: Parents/caregiversof children with asthma have a lower quality of life compared to parents/caregivers of healthy children.
Descritores: Pais
Qualidade de Vida
Asma
Cuidadores
-Índice de Gravidade de Doença
Estudos de Casos e Controles
Autorrelato
Limites: Seres Humanos
Masculino
Feminino
Criança
Adulto
Responsável: BR1.1 - BIREME


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Solé, Dirceu
Texto completo
Id: biblio-977088
Autor: Aranda, Carolina Sanchez; Wandalsen, Gustavo Falbo; Bianca, Ana Caroline Cavalcanti Dela; Dantas, Ellen de Oliveira; Mallol, Javier; Solé, Dirceu.
Título: Comparação temporal da prevalência de sibilância no primeiro ano de vida em são paulo: estudo internacional de sibilância em lactentes / Temporal comparison of wheezing prevalence in the first year of life in são paulo: international study of wheezing in infants
Fonte: Rev. Paul. Pediatr. (Ed. Port., Online);36(4):445-450, out.-dez. 2018. tab.
Idioma: pt.
Resumo: RESUMO Objetivo: Avaliar a prevalência e a gravidade da sibilância em lactentes no primeiro ano de vida, utilizando o protocolo padronizado do Estudio Internacional de Sibilancias en Lactantes- fase 3, e comparar os valores obtidos com os observados no Estudio Internacional de Sibilancias en Lactantes- fase 1, realizado no mesmo centro. Métodos: Entre 2009 e 2010, pais e responsáveis de lactentes responderam ao questionário escrito do Estudio Internacional de Sibilancias en Lactantes- fase 3, e os resultados obtidos foram comparados aos do Estudio Internacional de Sibilancias en Lactantes- fase 1, realizado entre 2005 e 2006. Oslactentes foram separados em sibilantes e "não sibilantes". Osprimeiros foram divididos de acordo com a frequência dos episódios: sibilância ocasional, quando apresentaram menos de três, e sibilância recorrente, quando manifestaram três ou mais. Resultados: A prevalência de sibilantes foi similar nas duas fases (44,6 versus46%). Segundo a frequência, houve aumento na prevalência de sibilância ocasional (19,4 versus 23%; p=0,03) e redução na de sibilância recorrente (26,7 versus 21,6%; p=0,005). Observou-se, ainda, aumento expressivo no diagnóstico de asma (7,5 versus 21,8%) e no uso de corticosteroides inalatórios (11,7 versus 35%), como também na hospitalização por sibilância na fase 3 (19,7 versus 32,6%), período da pandemia Influenza A (H1N1), o que pode ter contribuído para este desfecho. Conclusões: A prevalência da sibilância no primeiro ano de vida permanece elevada. Apesar de a avaliação temporal mostrar queda na prevalência da sibilância recorrente, aumento significante de sua morbidade foi identificado pelo maior número de hospitalizações. Além disso, houve indícios de melhora no manejo da sibilância dos lactentes, refletido pelo aumento do diagnóstico de asma e maior indicação de tratamentos preventivos.

ABSTRACT Objective: To assess the prevalence and severity of wheezing in the first year of life of infants, using the standardized protocol of the Estudio Internacional de Sibilancias en Lactantes- phase 3, and compare the values obtained with those found in phase 1, conducted at the same center. Methods: Between 2009 and 2010, parents and guardians of infants answered the written questionnaire of the Estudio Internacional de Sibilancias en Lactantes - phase 3, and its results were compared to those of phase 1, performed between 2005 and 2006. We divided the infants into wheezing and non-wheezing. The wheezing group was stratified according to the frequency of episodes: occasional wheezing - less than three -, and recurrent wheezing - three or more. Results: Wheezing prevalence was similar in both phases (44.6 versus 46%). Regarding frequency, the prevalence of occasional wheezing increased (19.4 versus 23%; p=0.03) and recurrent wheezing decreased (26.7 versus 21.6%; p=0.005). Also, diagnosis of asthma (7.5 versus 21.8%), use of inhaled corticosteroids (11.7 versus35%), and hospitalization for wheezing (19.7 versus 32.6%) grew significantly in phase 3. This period coincides with the Influenza A (H1N1) pandemic, which could have contributed to this outcome. Conclusions: Wheezing prevalence in the first year of life remains high. Despite the temporal assessment showing a decrease in the prevalence of recurrent wheezing, a significant increase in its morbidity was identified due to the higher number of hospitalizations. In addition, there were signs of improvement in the wheezing management of infants, reflected by an increase in the diagnosis of asthma and a greater indication of preventive treatments.
Descritores: Sons Respiratórios
-Fatores de Tempo
Índice de Gravidade de Doença
Brasil
Prevalência
Internacionalidade
Limites: Seres Humanos
Masculino
Feminino
Lactente
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-949955
Autor: Gonul, Muzeyyen; Cemil, Bengu Cevirgen; Ayvaz, Havva Hilal; Cankurtaran, Eylem; Ergin, Can; Gurel, Mehmet Salih.
Título: Comparison of quality of life in patients with androgenetic alopecia and alopecia areata
Fonte: An. bras. dermatol;93(5):651-658, Sept.-Oct. 2018. tab, graf.
Idioma: en.
Resumo: Abstract: Background: Androgenetic alopecia is one of the most common forms of hair loss. Alopecia areata is a common autoimmune disorder which causes hair loss. It has been previously reported that both alopecia disorders can have negative effects on quality of life. However, only a few studies have compared the effects of the two disorders. Objective: The aim is to show the impact of alopecia on patients' quality of life and compare patients with androgenetic alopecia and alopecia areata. Methods: 82 androgenetic alopecia and 56 alopecia areata patients were recruited. All patients were evaluated with the Hairdex scale and dermatology quality of life instrument in Turkish (TQL), and the scores were statistically compared according to age, sex, employment and education status, and severity of illness in the two groups. Also, female patients were statistically evaluated according to whether they wore headscarves. Results: Androgenetic alopecia patients had significantly higher total Hairdex scores in terms of emotions, functioning, and symptoms, while self-confidence was significantly higher in the alopecia areata patients. No significant differences were found in stigmatization or TQL scores between groups. The Hairdex scale and TQL scores did not show differences between the groups in terms of wearing headscarves. Study limitations: The validity and reliability of the Hairdex index have not been established in Turkey. Conclusions: Based on the Hairdex scale, our findings revealed that androgenetic alopecia patients are more affected by their disorder than alopecia areata patients. Although androgenetic alopecia is common and neither life-threatening nor painful, it is a stressful disorder with increased need for improvement in the patient's quality of life.
Descritores: Qualidade de Vida/psicologia
Alopecia/psicologia
Alopecia em Áreas/psicologia
-Autoimagem
Turquia
Índice de Gravidade de Doença
Inquéritos e Questionários
Distribuição por Sexo
Limites: Seres Humanos
Masculino
Feminino
Adolescente
Adulto
Adulto Jovem
Tipo de Publ: Estudo Comparativo
Responsável: BR1.1 - BIREME


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Id: biblio-949930
Autor: Borges, Isabela Bruna Pires; Silva, Marilda Guimarães; Shinjo, Samuel Katsuyuki.
Título: Prevalence and reactivity of anti-melanoma differentiation-associated gene 5 (anti-MDA-5) autoantibody in Brazilian patients with dermatomyositis
Fonte: An. bras. dermatol;93(4):517-523, July-Aug. 2018. tab.
Idioma: en.
Projeto: FAPESP.
Resumo: Abstract: Background: There have been no studies to date on the frequency and reactivity of aanti-melanoma differentiation-associated gene 5 (anti-MDA-5) in samples from the Brazilian population with dermatomyositis. Objectives: To analyze this autoantibody in the Brazilian population. Methods: This was a single-center cross-sectional study in which 131 consecutive adult patients (109 dermatomyositis and 22 clinically amyopathic dermatomyositis) with active disease were evaluated from 2000 to 2016. Analysis of the anti-MDA-5 autoantibody was performed by ELISA. Results: The presence of this autoantibody was observed in 14.7% and 22.7% of patients with dermatomyositis and clinically amyopathic dermatomyositis, respectively. In the case of dermatomyositis, the autoantibody was associated less frequently with Raynaud's phenomenon and periungual hyperemia (P<0.05). In clinically amyopathic dermatomyositis, the presence of this autoantibody was not associated statistically with any demographic, clinical, laboratory, or imaging characteristics. Study limitations: The cross-sectional study design did not allow establishing a temporal correlation between anti-MDA-5 autoantibody and various study variables. In addition, pulmonary function tests were not performed in the patients. Conclusions: The frequency of anti-MDA-5 autoantibody was comparable to that of other populations with dermatomyositis, but with a different reactivity than described in the literature. In addition, there was a phenotypic variability between our patients with clinically amyopathic dermatomyositis and those described in the literature. Further studies are needed to confirm the current study's findings and elucidate this autoantibody's reactivity in Brazilians with idiopathic inflammatory myopathies.
Descritores: Autoanticorpos/sangue
Dermatomiosite/imunologia
Helicase IFIH1 Induzida por Interferon/imunologia
-Autoanticorpos/imunologia
Índice de Gravidade de Doença
Ensaio de Imunoadsorção Enzimática
Estudos Transversais
Estatísticas não Paramétricas
Progressão da Doença
Dermatomiosite/complicações
Dermatomiosite/sangue
Helicase IFIH1 Induzida por Interferon/sangue
Limites: Seres Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-983726
Autor: Souza, Carlos Dornels Freire de.
Título: Physical disability and Hansen's disease in Brazil in the 21st century: Brief analysis
Fonte: An. bras. dermatol;94(1):107-108, Jan.-Feb. 2019. tab.
Idioma: en.
Descritores: Pessoas com Deficiência/estatística & dados numéricos
Avaliação da Deficiência
Hanseníase/epidemiologia
-Índice de Gravidade de Doença
Brasil/epidemiologia
Prevalência
Hanseníase/complicações
Hanseníase/fisiopatologia
Limites: Seres Humanos
Tipo de Publ: Carta
Responsável: BR1.1 - BIREME


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Id: biblio-973646
Autor: Salman, Andac; Yucelten, Ayse Deniz; Sarac, Esra; Saricam, Merve Hatun; Perdahli-Fis, Nese.
Título: Impact of psoriasis in the quality of life of children, adolescents and their families: a cross-sectional study
Fonte: An. bras. dermatol;93(6):819-823, Nov.-Dec. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: Psoriasis is a chronic and inflammatory disease that impairs quality of life and causes psychological symptoms. Despite the high prevalence of psoriasis in pediatric patients, studies investigating the impact of psoriasis in the quality of life of children, adolescents and families are sparse. Objective: To investigate the impact of psoriasis in the quality of life of children and adolescents with psoriasis and their families and to determine depression and anxiety levels of the patients. Methods: A total of 58 patients with psoriasis aged 7-18 years (median age: 11) and a family member of each patient were included in the study. Children's Dermatology Life Quality Index (CDLQI), Family Dermatology Life Quality Index (FDLQI), Children's Depression Inventory (CDI) and State-Trait Anxiety Inventory for Children (STAIC) were used in the study. Results: The median PASI score of the patients included in the study was 1.8. The median CDLQI and FDLQI scores in the study groups were 5 and 10, respectively. The median CDI score, STAIC-state and STAIC-trait scores of the patients were 6, 28 and 32.5, respectively. Study limitations: Lack of a control group and patient assessment of disease severity. Relatively mild disease severity of the subjects. Conclusions: Psoriasis has a negative impact in the quality of life of children, adolescents and their families, even in the presence of mild disease. Considering that impairment in quality of life may be associated with psychosocial morbidity, a combined approach with medical therapy, family counseling and quality of life assessment may be beneficial in this patient group.
Descritores: Ansiedade/psicologia
Psoríase/psicologia
Qualidade de Vida/psicologia
Família/psicologia
Depressão/psicologia
-Índice de Gravidade de Doença
Estudos Transversais
Inquéritos e Questionários
Limites: Seres Humanos
Masculino
Feminino
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Id: biblio-973641
Autor: Morais, Marina Resener de; Martins, Gladys Aires; Romiti, Ricardo; Tonoli, Renata Elise; Carvalho, André Vicente Esteves.
Título: Translation and validation of the Simplified Psoriasis Index (SPI) into Brazilian Portuguese
Fonte: An. bras. dermatol;93(6):813-818, Nov.-Dec. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: The Simplified Psoriasis Index is a tool that assesses the current severity, psychosocial impact, past history and interventions in patients with psoriasis through separate components. Two versions are available, one in which the current severity of the disease is evaluated by the patient themselves and another by the physician. Objectives: Translate the Simplified Psoriasis Index into Brazilian Portuguese and verify its validity. Methods: The study was conducted in two stages; the first stage was the translation of the instrument; the second stage was the instrument's validation. Results: We evaluated 62 patients from Complexo Hospitalar Santa Casa de Porto Alegre and Hospital Universitário de Brasília. The Simplified Psoriasis Index translated into Portuguese showed high internal consistency (Cronbach test 0.68). Study limitations: Some individuals, because of poor education, might not understand some questions of the Simplified Psoriasis Index. Conclusions: The Brazilian Portuguese version of the Simplified Psoriasis Index was validated for our population and can be recommended as a reliable instrument to assess the patients with psoriasis.
Descritores: Psoríase/diagnóstico
-Psoríase/classificação
Traduções
Índice de Gravidade de Doença
Brasil
Valor Preditivo dos Testes
Inquéritos e Questionários
Reprodutibilidade dos Testes
Sensibilidade e Especificidade
Características Culturais
Linguagem
Limites: Seres Humanos
Masculino
Feminino
Adulto
Meia-Idade
Tipo de Publ: Estudos de Validação
Responsável: BR1.1 - BIREME


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Texto completo
Id: biblio-973637
Autor: Kurizky, Patricia Shu; Martins, Gladys Aires; Carneiro, Jamille Nascimento; Gomes, Ciro Martins; Mota, Licia Maria Henrique da.
Título: Evaluation of the occurrence of sexual dysfunction and general quality of life in female patients with psoriasis
Fonte: An. bras. dermatol;93(6):801-806, Nov.-Dec. 2018. tab.
Idioma: en.
Resumo: Abstract: Background: Psoriasis has a significant impact on quality of life (QoL). Sexual life can also be affected, with sexual dysfunction being reported by 25-70% of patients. Objectives: To determine the occurrence of sexual dysfunction and evaluate QoL in women with psoriasis. Methods: This case-control study included women aged 18-69 years. The validated Brazilian Portuguese versions of the Female Sexual Function Index (FSFI) and of the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) were administered to all participants to assess sexual function and QoL, respectively. Patients with psoriasis underwent clinical evaluation for the presence of comorbidities, especially psoriatic arthritis and other rheumatic manifestations. Location of lesions and the extent of skin involvement were also assessed. Results: The sample consisted of 150 women, 75 with diagnosis of psoriasis and 75 healthy controls. Prevalence of sexual dysfunction was high in women with psoriasis (58.6% of the sample). Prevalence was statistically higher in women with psoriasis than in controls (P = 0.014). The SF-36 domain scores were also lower in women with psoriasis, with role limitations due to physical health, limitations due to emotional problems, and mental health being the most affected domains. Study limitations: Sample size was calculated to evaluate the association between the occurrence of sexual dysfunction and psoriasis, but it did not include the determination of the possible causes of this dysfunction. Conclusions: QoL and sexual function were altered in women with psoriasis and should be taken into consideration when assessing disease severity.
Descritores: Psoríase/psicologia
Qualidade de Vida/psicologia
Disfunções Sexuais Psicogênicas/psicologia
-Psoríase/complicações
Psoríase/epidemiologia
Índice de Gravidade de Doença
Brasil/epidemiologia
Estudos de Casos e Controles
Prevalência
Inquéritos e Questionários
Disfunções Sexuais Psicogênicas/epidemiologia
Limites: Seres Humanos
Feminino
Adolescente
Adulto
Meia-Idade
Idoso
Adulto Jovem
Responsável: BR1.1 - BIREME



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