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Texto completo SciELO Chile
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Id: biblio-1094187
Autor: Merello, Lorenzo; Salazar M, Rodrigo; Elgueta G, Felipe; González, Diego; Elton, Victoria; Quiroz, Manuel; Pedemonte, Oneglio; Aránguiz-Santander, Ernesto.
Título: Sobrevida a 10 años de pacientes egresados luego de cirugía por endocarditis infecciosa en un hospital público / Hospital mortality and long-term survival of 103 patients with infective endocarditis requiring surgery
Fonte: Rev. méd. Chile;147(12):1535-1542, dic. 2019. tab, graf.
Idioma: es.
Resumo: Background Infective endocarditis (IE) is a serious disease with high mortality, especially among the most severe cases undergoing surgery. Aim To analyze the clinical features, perioperative mortality and long-term survival of patients with infective endocarditis requiring surgery. Material and Methods Review of medical records of patients who underwent heart valve surgery for active infective endocarditis in a public hospital between 1995 and 2008. Demographic characteristics and comorbidities were described. Perioperative and 10 year survival were analyzed retrieving death certificates from the Chilean Identification Service. Results Data from 103 patients aged 46 ± 14 years (74% males) was analyzed. Thirty five percent of patients had an underlying predisposing heart condition such as congenital heart disease in 18.5% and prosthetic valves in 10%. The most common location was the aortic valve and the most common surgical procedure was heart valve replacement with a mechanical prosthetic valve in 87% of the cases. Pathogen identification in blood cultures was achieved in 48% of the cases. The most common causative microorganisms were S. aureus in 12%, coagulase-negative Staphylococcus in 11%, S. viridans in 10% and Enterococcus in 7%. Hospital mortality was 20.4% and ten-year survival was 65%. Conclusions Patients with severe IE requiring surgical treatment still have high perioperative and late mortality.
Descritores: Endocardite Bacteriana/mortalidade
-Análise de Sobrevida
Estudos Retrospectivos
Mortalidade Hospitalar
Endocardite Bacteriana/cirurgia
Endocardite Bacteriana/microbiologia
Hospitais Públicos
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1094166
Autor: Peña, Camila; Valladares, Ximena; Gajardo, Claudia; Russo, Moisés; Morales, Álvaro; Correa, Gonzalo; Valjalo, Ricardo.
Título: Prognostic impact of renal failure recovery in patients with newly diagnosed multiple mieloma / Impacto pronóstico de remisión renal en pacientes con mieloma múltiple de reciente diagnóstico
Fonte: Rev. méd. Chile;147(11):1374-1381, nov. 2019. tab, graf.
Idioma: en.
Resumo: ABSTRACT Background Renal failure (RF) is a common complication in patients with newly diagnosed multiple myeloma (NDMM). Aim To evaluate the frequency of RF in NDMM patients, and the prognostic impact of its reversibility. Material and Methods A retrospective study evaluating demographic and clinical characteristics of 154 consecutive patients with NDMM was carried out. Estimated glomerular filtration rate (eGFR) was calculated at the beginning and at the end of the induction therapy. In addition, we evaluated renal responses (RR) according to the International Myeloma Working Group (IMWG) criteria. The induction regimen was based on thalidomide in all cases. Results Fifty-three patients had RF (34.4%). Complete renal response (RR) was achieved in 51%. Three years overall survival in patients without RF, with RF and complete RR, and patients with RF and any other RR, was 66, 47 and 13%, respectively. Median survival was 53, 27 and 6 months, respectively (p < 0.01). In the multivariate analysis, RF and hypercalcemia were independent predictors of a worse outcome. Conclusions Achieving a complete RR in patients with NDMM, is associated with a better survival.

Antecedentes La falla renal (FR) es una complicación frecuente en pacientes con mieloma múltiple (MM). Objetivo Evaluar la frecuencia de FR en pacientes con reciente diagnóstico de MM y determinar la importancia pronóstica de su reversibilidad. Material y Métodos Se realizó un estudio retrospectivo de 154 pacientes consecutivos con MM. La función renal se evaluó mediante la tasa estimada de filtración glomerular al inicio y final de la terapia de inducción. Además, evaluamos las respuestas renales (RR) de acuerdo con los criterios del International Myeloma Working Group (IMWG). El régimen de inducción se basó en talidomida en todos los casos. Resultados Cincuenta y tres pacientes presentaron FR (34,4%) al diagnóstico. La RR completa se logró en 51%. La sobrevida global (SG) a 3 años en pacientes sin FR, con FR y RR completa, y pacientes con FR y cualquier otra RR, fue de 66, 47 y 13%, respectivamente. La SG media fue de 53, 27 y 6 meses (p < 0,01), respectivamente. En el análisis multivariado, la FR y la hipercalcemia fueron factores independientes de menor sobrevida. Conclusiones Lograr una RR completa en pacientes con MM recién diagnosticado se asocia con una mejor sobrevida.
Descritores: Insuficiência Renal/etiologia
Mieloma Múltiplo/complicações
-Prognóstico
Indução de Remissão
Protocolos de Quimioterapia Combinada Antineoplásica
Análise de Sobrevida
Estudos Retrospectivos
Taxa de Filtração Glomerular
Mieloma Múltiplo/tratamento farmacológico
Estadiamento de Neoplasias
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1150160
Autor: Amorim, Marília de de Matos; Leite, Maria C. Silva; Alves, Lisia Daltro Borges; Silva, Carlos A. Lima da; Santos, Jean Nunes dos; Reitas, Valéria Souza.
Título: Sobrevida de adultos jovens com carcinoma de células escamosas oral em uma população do Brasil / Survival of young adults with oral squamous cell carcinoma in a brazilian population / Supervivencia de adultos jóvenes con carcinoma de células escamosas orales en una población de Brasil
Fonte: Rev. salud pública;21(5):e208, sep.-oct. 2019. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo Analisar o perfil e a sobrevida de adultos jovens com carcinoma de células escamosas oral, atendidos entre 2010 a 2016 na Unidade de Alta Complexidade em Oncologia de Feira de Santana, Brasil. Métodos Coorte retrospectiva, realizada através das informações dos prontuários de todos os pacientes jovens atendidos no referido centro. Foi realizada análise descritiva das variáveis, teste exato de Fisher, curva de Kaplan-Meier e teste log rank. Resultados Um total de 35 pacientes foram registrados. A maioria era do sexo masculino, fumantes e etilistas. Os tumores estavam localizados predominantemente em língua, diagnosticados tardiamente e classificados como bem diferenciado, tendo como tratamento de escolha cirurgia associada a radioterapia e quimioterapia. O tempo mediano de sobrevida foi de 31 meses e 22,8% dos pacientes foram a óbito. As variáveis que apresentaram significância estatística em relação ao tempo de sobrevida foram a localização do tumor e o tipo de tratamento. Conclusão O perfil e o baixo tempo de sobrevida refletem a necessidade de uma maior atenção à doença nesta população.(AU)

ABSTRACT Objective To analyze the profile and survival in young adults with oral squamous cell carcinoma, attended at the High Complexity in Oncology of Feira de Santana, Brazil, between 2010 and 2016. Methods Retrospective cohort, performed through the information of the medical records of all young patients attended in the referred center. Descriptive analysis of the variables, Fisher's exact test, Kaplan-Meier curve and log-rank test were performed. Results A total of 35 patients were registered. The majority were male, smokers and former alcoholics. Tumors were predominantly localized in the tongue, diagnosed at late stages, classified as well differentiated and treated mainly with surgery associated to radiotherapy and chemotherapy. The median survival time was 31 months and 22.8% of the patients died. The variables that presented statistical significance in relation to the survival time were the tumor site and the type of treatment. Conclusion The profile and low survival time reflect the need for greater attention to the disease in this population.(AU)

RESUMEN Objetivo Analizar el perfil y la supervivencia de adultos jóvenes con carcinoma de células escamosas atendidos en el Centro de Alta Complejidad en Oncología de Feira de Santana (Brasil), durante el periodo 2010-2016. Métodos cohorte retrospectivo realizado mediante la información de registros médicos de todos los pacientes jóvenes atendidos en el centro médico mencionado. Asimismo, se hizo un análisis descriptivo de las variables, test exacto de Fisher, curva de Kaplan-Meier y una prueba de rango logarítmico. Resultados Se registró un total de 35 pacientes: la mayoría, hombres fumadores y exalcohólicos. Gran parte de los tumores fueron hallados en la lengua y diagnosticados en la última fase; asimismo, se clasificaron, se diferenciaron y se trataron con cirugía apoyada en radioterapia y quimioterapia. El tiempo promedio de supervivencia fue de 31 meses. El 22,8% de los pacientes fallecieron. Las variables que demostraron una gran significancia estadística en relación con el tiempo de supervivencia fueron la ubicación del tumor y el tipo de tratamiento. Conclusión El perfil y el escaso tiempo de supervivencia demuestran que es necesaria una mejor atención de la enfermedad que padece esta población.(AU)
Descritores: Perfil de Saúde
Carcinoma de Células Escamosas/diagnóstico
-Prognóstico
Brasil/epidemiologia
Carcinoma de Células Escamosas/epidemiologia
Análise de Sobrevida
Estudos Retrospectivos
Estudos Longitudinais
Limites: Humanos
Adulto
Tipo de Publ: Estudo Observacional
Responsável: BR1.1 - BIREME


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Id: biblio-1148102
Autor: Brusca, S; Penayo Zárate, M A; Galván, M E; Latini, B; Fridman, C; Herrera, M; Flores Tonfi, M L; Ghibaudi, G; Buamscha, D.
Título: Terapias de reemplazo renal contínuas (TRRC) en pacientes críticos inmunosuprimidos / Continuous renal replacement therapies (CRRT) in critically ill immunosuppressed patients
Fonte: Med. infant;27(2):107-112, Diciembre 2020. ilus, Tab.
Idioma: es.
Resumo: La injuria renal aguda (IRA) se caracteriza por un abrupto deterioro de la función renal asociado a lteraciones hidroelectrolíticas y metabólicas. La misma es frecuente en la unidad de cuidados intensivos (UCI) pediátricos y tiene un impacto significativo en la morbilidad y mortalidad. Las principales indicaciones de terapia de reemplazo renal (TRR) incluyen la corrección de los trastornos metabólicos y el manejo de la sobrecarga de fluidos. Varios modos de TRR pueden ser utilizadas en la UCI: hemodiálisis intermitente, diálisis peritoneal y las terapias de reemplazo renal continuas (TRRC). Las terapias de reemplazo renal continuas han ganado un rol preponderante en Cuidados Críticos ya que posibilitan dializar a pacientes hemodinámicamente inestables. Del total de pacientes admitidos en la UCI (n:1506) desde enero 2012 hasta diciembre 2018, requirieron TRRC el 6,7% (n: 102). La mortalidad predicha por el Score PIM3 fue de 19,53%, la mediana de edad en meses fue de 60 (RIC 25-75: 12-144), no hubo diferencias en cuanto al sexo. Los diagnósticos más frecuentes fueron trasplantados de órganos sólidos 33%, seguidos de trasplante de células progenitoras hematopoyéticas (TCPH) el 26%. La mediana de los días de internación fue de 16 (RIC 25-75: 7-29) y de días de requerimiento de una TRRC 5 (RIC 25-75 3-9). La técnica dialítica más utilizada fue CVVHD, en el 87% de los pacientes. La mortalidad global fue del 75%, presentando los pacientes con TCPH mayor mortalidad con respecto a otros diagnósticos. Se debe reconocer y categorizar precozmente a los pacientes con mayor riesgo de desarrollar IRA y aplicar medidas de nefroprotección para mejorar su sobrevida (AU)

Acute renal injury (IRA) is characterized by sudden deterioration of kidney function associated with hydroelectrolytic and metabolic disturbances. IRA is common in the pediatric intensive care unit (ICU) and has a significant impact on morbidity and mortality. The main indications for renal replacement therapy (RRT) include correction of the metabolic disorders and management of fluid overload. Different types of RRT may be used in the ICU: intermittent hemodialysis, peritoneal dialysis, and continuous renal replacement therapies (CRRT). Continuous renal replacement therapies have gained a major role in critical care as they allow for dialysis in hemodynamically unstable patients. Of all patients admitted to the ICU (n:1506) between January 2012 and December 2018, 6.7% required CRRT (n: 102). Predicted mortality rate according to the PIM3 score was 19.53%. Median age was 60 months (IQR 25-75: 12-144). No differences in sex were observed. The most common diagnoses were solid organ transplantation in 33%, followed by hematopoietic stem cell transplantation (HSCT) in 26%. Median length of hospital stay was 16 days (IQR 25-75: 7-29) and median days on CTTT was 5 (IQR 25-75 3-9). The most common dialysis technique was CVVHD, used in 87% of the patients. Overall mortality rate was 75%, with a higher mortality in HSCT patients compared to others. Patients at a higher risk of developing IRA should be timely recognized and categorized and nephroprotective measures should be started early to improve survival (AU)
Descritores: Desequilíbrio Hidroeletrolítico
Unidades de Terapia Intensiva Pediátrica
Hospedeiro Imunocomprometido
Estado Terminal
Lesão Renal Aguda/terapia
Terapia de Substituição Renal Contínua
-Análise de Sobrevida
Estudos Retrospectivos
Resultado do Tratamento
Limites: Humanos
Lactente
Pré-Escolar
Criança
Tipo de Publ: Estudo Observacional
Responsável: AR305.1 - SID - Servicio de Información y Documentación


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Id: biblio-1013974
Autor: Alfaro-Campos, Grethel Carolina; Vargas-Bermúdez, Alejandro.
Título: Aplicación del índice pronóstico de supervivencia Pap score en el paciente oncológico referido al Centro Nacional de Control del Dolor y Cuidados Paliativos en Costa Rica / Application of the survival prognosis index (Pap score) in the oncological patient referred to the National Center for Pain Control and Palliative Care in Costa Rica
Fonte: Rev. costarric. salud pública;28(1):36-47, ene.-jun. 2019. tab, graf.
Idioma: es.
Resumo: Resumen Objetivo: Determinar la validez del Índice de Pronóstico de Supervivencia (PapScore) en los pacientes oncológicos referidos al Centro Nacional de Control del Dolor y Cuidados Paliativos de Costa Rica. Métodos: Estudio descriptivo, observacional y prospectivo de los pacientes oncológicos referidos por primera vez al Centro Nacional de Control del Dolor y Cuidados Paliativos durante los meses de mayo y junio del 2015. Se aplicó el índice de pronóstico PaP Score. La base de datos fue realizada en Excel y el análisis estadístico en el programa SPSS. Resultados: Se estudiaron 100 pacientes, el 54% de sexo masculino, con una edad promedio 67,1 años. El cáncer gástrico fue la patología más prevalente con 12% de los casos. El 23% de pacientes presentan disnea, 56% anorexia. A la mayoría de pacientes (67%) se le realizó una estimación clínica mayor a 12 semanas. Un 83% fueron clasificados en el grupo A, 17% en el grupo B y ningún paciente en el grupo C. Analizando la clasificación de riesgo como un test diagnóstico para predecir mortalidad a un mes, muestra un sensibilidad del 61,9%, especificidad del 94,9%, con valor predictivo positivo 76,5% y valor predictivo negativo 90,4%. Conclusión: La escala de PaP Score o Índice Pronóstico de Supervivencia es un instrumento que se adapta a las posibilidades de nuestro entorno nacional. Es una excelente herramienta como predictor de sobrevida a un mes, independientemente del tipo de tumor, con alta eficacia y validez pronóstica.

Abstract Objective: To determine the validity of the Palliative Prognosis Index (PapScore) in cancer patients referred to the National Center for Pain Control and Palliative Care of Costa Rica. Methods: Descriptive, observational and prospective study of oncological patients referred for the first time to the National Center of Pain Control and Palliative Care during the months of May and June 2015. The PaP Score was used. The database was made in Excel and the statistical analysis in the SPSS program. Results: 100 patients were studied, 54% male, with an average age of 67.1 years. Gastric cancer was the most prevalent pathology with 12% of cases, 23% of patients present dyspnea, 56% anorexia. The majority of patients (67%) underwent a clinical prognosis of more than 12 weeks, 83% were classified in group A, 17% in group B and no patient in group C. Analyzing the risk classification as a diagnostic test to predict mortality at one month, shows a sensitivity of 61.9%, specificity 94.9%, with positive predictive value 76.5% and negative predictive value 90.4%. Conclusion: The PaP Score or Palliative Prognosis Index scale is an instrument that adapts to the possibilities of our national environment. It is an excellent tool as a predictor of survival at one month, regardless of the type of tumor, with high efficacy and prognostic validity.
Descritores: Cuidados Paliativos
Análise de Sobrevida
Neoplasias/mortalidade
-Costa Rica
Neoplasias/epidemiologia
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Idoso
Idoso de 80 Anos ou mais
Tipo de Publ: Estudo Comparativo
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Texto completo SciELO Chile
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Id: biblio-991349
Autor: González L, Roberto; Reyes M, Rodrigo; Stockins L, Aleck; Seguel S, Enrique; Jadue T, Andrés; Alarcón C, Emilio.
Título: Cirugía coronaria: resultados inmediatos y alejados de la cirugía de revascularización miocárdica en enfermedad coronaria / Early and late results of coronary artery bypass grafting in coronary artery disease in Concepcion, Chile
Fonte: Rev. méd. Chile;146(12):1395-1404, dic. 2018. tab, graf.
Idioma: es.
Resumo: Background: Coronary artery bypass grafting (CABG) is the best treatment for a large group of patients with coronary artery disease. Aim: To describe early and late results of patients treated with CABG at our Center. Patients and Methods: Revision of data bases, surgical protocols and clinical registers of patients operated between January 2006 and December 2008. Results: Of 1.003 cardiac surgeries performed during the period, 658 corresponded to isolated CABG (78% in men). The median age of patients was 62 years. Left common coronary artery lesions was found in 135 cases (20%), 555 patients (84%) had hypertension and 231 (35%) were diabetics. Four-hundred thirty (65%) had stable angina and 211 (32%) had a recent myocardial infarction. Twenty-two had left ventricular ejection fraction < 30%. In 248 (38%), a low Additive EuroSCORE risk was found. Emergency surgery was required in 36 (6%) patients. Use of extracorporeal circulation was required in 466 patients (71%). Within 30 days of surgery, complications were recorded in 105 patients (16%) (15 (2%) stroke, 14 (2%) myocardial infarction, 7 (1%) mediastinitis, and in 14 (2%) a reoperation for bleeding). Thirteen patients died (2%). Among the 303 patients with stable angina and preserved left ventricular function, two died (0,7%). Survival at 1, 3 and 5 years was 97,4%, 93,8% y 90,9% respectively. Major adverse cardiac and cerebrovascular events at five years occurred in 20%, stroke in 4%, myocardial infarction in 3% and reintervention in 2%. Seven percent of patients had recurrence of angina. Conclusions: We describe a heterogeneous series of patients. The immediate and late results are comparable with international communications.
Descritores: Doença da Artéria Coronariana/cirurgia
Ponte de Artéria Coronária/mortalidade
-Doença da Artéria Coronariana/mortalidade
Análise de Sobrevida
Chile
Resultado do Tratamento
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-991354
Autor: Calderillo-Ruiz, Germán; Herrera-Goepfert, Roberto; Díaz-Romero, Consuelo; Carbajal-López, Berenice; López-Basave, Horacio.
Título: Carcinoma epidermoide puro-combinado de vesícula biliar / Gallbladder epidermoid carcinoma
Fonte: Rev. méd. Chile;146(12):1438-1443, dic. 2018. tab, graf.
Idioma: es.
Resumo: Background: Gallbladder epidermoid carcinoma is rare and more common in women over 55 years of age. Aim: To report the features of 15 patients with gallbladder epidermoid carcinoma. Material and Methods: Review of medical records of patients with gallbladder cancer in an oncology service. Results: Of 207 patients with gallbladder cancer, 15patients aged 53-72years, 93% women had an epidermoid component in their cancer. Forty percent were diabetic and 33% had cholelithiasis. All had locoregional extension of the tumor. A cholecystectomy was done in nine patients (using open surgery in six). In six patients, only a biopsy was done. Median survival was 4.2 months. Conclusions: Gallbladder epidermoid carcinoma is uncommon and has a bad prognosis.
Descritores: Carcinoma de Células Escamosas/mortalidade
Neoplasias da Vesícula Biliar/mortalidade
-Prognóstico
Carcinoma de Células Escamosas/sangue
Carcinoma de Células Escamosas/terapia
Análise de Sobrevida
Estudos Retrospectivos
Neoplasias da Vesícula Biliar/sangue
Neoplasias da Vesícula Biliar/terapia
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Texto completo SciELO Saúde Pública
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Id: biblio-890211
Autor: Ferraz, Rosemeire de Olanda; Moreira-Filho, Djalma de Carvalho.
Título: Análise de sobrevivência de mulheres com câncer de mama: modelos de riscos competitivos / Survival analysis of women with breast cancer: competing risk models
Fonte: Ciênc. Saúde Colet;22(11):3743-3754, Nov. 2017. tab, graf.
Idioma: pt.
Resumo: Resumo O objetivo deste estudo foi estimar os efeitos de fatores prognósticos na sobrevida do câncer de mama, como idade, estadiamento e extensão do tumor, utilizando modelos de riscos proporcionais de Cox e de riscos competitivos de Fine-Gray. É um estudo de coorte retrospectiva de base-populacional referente a 524 mulheres diagnosticadas com câncer de mama no período de 1993 a 1995, acompanhadas até 2011, residentes no município de Campinas, São Paulo, Brasil. O ponto de corte (cutoff) da variável idade foi definido utilizando-se modelos simples de Cox. Nos ajustes de modelos simples e múltiplo de Fine-Gray, a idade não foi significativa na presença de riscos competitivos e nem nos modelos de Cox, considerando-se, para ambas as modelagens, óbito por câncer de mama como desfecho de interesse. As curvas de sobrevidas estimadas por Kaplan-Meier evidenciaram diferenças expressivas para óbitos por câncer de mama e por riscos competitivos. As curvas de sobrevida por câncer de mama não apresentaram diferenças significativas quando comparados os grupos de idades, segundo teste de log rank. Os modelos de Cox e de Fine-Gray identificaram os mesmos fatores prognósticos que influenciavam na sobrevida do câncer de mama.

Abstract This study aimed to estimate the effects of prognostic factors on breast cancer survival, such as age, staging, and extension of the tumor, using proportional hazards and competing risks models proposed by Cox and Fine-Gray, respectively. This is a retrospective cohort study, based on a population of 524 women, who were diagnosed with breast cancer in the period from 1993 to 1995 and monitored until 2011, residents in the city of Campinas, São Paulo, Brazil. The cutoff points for the variable of age were defined with Cox simple models. In the settings of simple and multiple Fine-Gray models, age was not significant to the presence of competing risks, neither it was in Cox models. For both models, death by breast cancer was the event of interest. The survival functions, estimated by Kaplan-Meier, showed significant differences for deaths by breast cancer and by competing risks. Survival functions by breast cancer did not show significant differences when comparing the age groups, according to log-rank test. Cox and Fine-Gray models identified the same prognostic factors that influenced in breast cancer survival.
Descritores: Neoplasias da Mama/patologia
Modelos Estatísticos
-Prognóstico
Brasil/epidemiologia
Neoplasias da Mama/epidemiologia
Modelos de Riscos Proporcionais
Análise de Sobrevida
Estudos Retrospectivos
Fatores de Risco
Estudos de Coortes
Fatores Etários
Pessoa de Meia-Idade
Estadiamento de Neoplasias
Limites: Humanos
Feminino
Adulto
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
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Id: biblio-991368
Autor: Mendoza, María Gabriela; Valladares, Ximena; Roa, Macarena; Reyes, Margarita; Osorio, Rocío; Undurraga, María Soledad; Legües, María Eugenia; Cabrera, María Elena; Peña, Camila.
Título: Leucemia de células plasmáticas primaria: experiencia en un hospital público chileno / Primary plasma cell leukemia: report of five cases
Fonte: Rev. méd. Chile;147(1):18-23, 2019. tab, graf.
Idioma: es.
Resumo: Background: Primary plasma cell leukemia (pPCL) is uncommon, aggressive and has a different biology than multiple myeloma (MM). Aim: To report the features of patients with pPCL. Material and Methods: Review of databases of the Hematology Department and the Hematology laboratory. Results: Of 178 patients with monoclonal gammopathies, five (2.8%) patients aged 33 to 64 years (three females) had a pPCL. The mean hemoglobin was 7.3 g/dL, the mean white blood cell count was 52,500/mm3, with 58% plasma cells, and the mean platelet count was 83,600/mm3. The mean bone marrow infiltration was 89%, LDH was 2,003 IU/L, serum calcium was 13 mg/dL, and creatinine 1.5 mg/dL. Two patients had bone lesions. Three were IgG, one IgA lambda and one lambda light chain. CD20 was positive in one, CD56 was negative in all and CD117 was negative in 3 cases. By conventional cytogenetic analysis, two had a complex karyotype. By Fluorescence in situ Hybridization, one was positive for TP53 and another for t (11; 14). One patient did not receive any treatment, three patients received VTD PACE and one CTD. None underwent transplant. Three patients are alive. The mean survival was 14 months. Conclusions: These patients with pPCL were younger and had a more aggressive clinical outcome than in multiple myeloma.
Descritores: Leucemia Plasmocitária/genética
Leucemia Plasmocitária/epidemiologia
-Paraproteinemias/genética
Paraproteinemias/patologia
Paraproteinemias/epidemiologia
Contagem de Células Sanguíneas
Leucemia Plasmocitária/patologia
Leucemia Plasmocitária/terapia
Análise de Sobrevida
Chile/epidemiologia
Cálcio/sangue
Estudos Retrospectivos
Resultado do Tratamento
Hibridização in Situ Fluorescente
Creatinina/sangue
Análise Citogenética
Citometria de Fluxo/métodos
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1151880
Autor: Dalibón, Albano.
Título: El control glucémico estricto en pacientes con diabetes tipo 2 disminuye los eventos cardiovasculares pero no la mortalidad en un seguimiento por diez años / Tigh glycemic control in patients with type 2 diabetes reduces cardiovascular events but not mortality in a follow up for ten years
Fonte: Evid. actual. práct. ambul;19(3):85-85, 2016. tab.
Idioma: es.
Descritores: Glicemia/metabolismo
Doenças Cardiovasculares/mortalidade
-Hemoglobina A Glicada/análise
Doenças Cardiovasculares/prevenção & controle
Ensaios Clínicos Controlados Aleatórios como Assunto
Análise de Sobrevida
Risco
Estudos Multicêntricos como Assunto
Diabetes Mellitus Tipo 2/mortalidade
Diabetes Mellitus Tipo 2/tratamento farmacológico
Diabetes Mellitus Tipo 2/sangue
Hipoglicemiantes/administração & dosagem
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Idoso
Tipo de Publ: Comentário
Responsável: AR2.1 - Biblioteca Central



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