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Id: lil-726239
Autor: Garcia, Leandro de Borborema; Andrade, José Santos Cruz de; Testa, José Ricardo Gurgel.
Título: Anatomical study of the pigs temporal bone by microdissection
Fonte: Acta cir. bras;29(supl.3):77-80, 2014. graf.
Idioma: en.
Resumo: PURPOSE: Initial study of the pig`s temporal bone anatomy in order to enable a new experimental model in ear surgery. METHODS: Dissection of five temporal bones of Sus scrofa pigs obtained from UNIFESP - Surgical Skills Laboratory, removed with hole saw to avoid any injury and stored in formaldehyde 10% for better conservation. The microdissection in all five temporal bone had the following steps: inspection of the outer part, external canal and tympanic membrane microscopy, mastoidectomy, removal of external ear canal and tympanic membrane, inspection of ossicular chain and middle ear. RESULTS: Anatomically it is located at the same position than in humans. Some landmarks usually found in humans are missing. The tympanic membrane of the pig showed to be very similar to the human, separating the external and the middle ear. The middle ear`s appearance is very similar than in humans. The ossicular chain is almost exactly the same, as well as the facial nerve, showing the same relationship with the lateral semicircular canal. CONCLUSION: The temporal bone of the pigs can be used as an alternative for training in ear surgery, especially due the facility to find it and its similarity with temporal bone of the humans. .
Descritores: Osso Temporal/anatomia & histologia
Microdissecção/métodos
-Materiais de Ensino
Osso Temporal/cirurgia
Modelos Animais
Sus scrofa
Microdissecção/educação
Orelha Média/anatomia & histologia
Orelha Média/cirurgia
Modelos Anatômicos
Limites: Animais
Responsável: BR1.1 - BIREME


  2 / 1091 LILACS  
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Moreira, Marise Amaral Rebouças
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Id: biblio-827655
Autor: Blumenschein, Alexandre Roriz; Freitas-Junior, Ruffo; Moreira, Marise Amaral Rebouças; Cysneiros, Maria-Auxiliadora Paula Carneiro; Pereira, Roseana Netto; Tufanin, Andrea Thomazine; Soares, Leonardo Ribeiro.
Título: Is the combination of fat grafts and platelet rich plasma effective in rats?
Fonte: Acta cir. bras;31(10):668-674, Oct. 2016. tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate if the association of fat grafts and platelet-rich plasma (PRP) improves graft viability in female rats. METHODS: This is an experimental, randomized and blinded study, which involved 47 rats. Fat was harvested from the inguinal region and grafted to the cranial region. The experimental group consisted of PRP-enriched fat grafts (n=22) whilst the control group consisted of fat graft only (n=25). After a 100-day period, the animals were euthanised and the fat grafts were analyzed using scores from 0 (absent) to 4 (abundant), in optical microscopy by two independent and blinded pathologists. RESULTS: Regarding fat graft cell viability, the PRP group scored moderate/abundant in 63% of cases and the fat graft only group scored absent/slight in 72% of cases (p=0.03). The PRP group also presented lower fat necrosis scores when compared to the fat graft only group (p=0.03). Tumors (dermoid cysts) within the fat grafts were observed in three animals in which the grafts were mixed with PRP. CONCLUSION: Platelet-rich plasma improves the viability and integration of fat grafts in rats, but more studies are needed to fully understand the exact mechanisms that lead to this improvement and assess the safety of the method for use in humans.
Descritores: Crânio/cirurgia
Tecido Adiposo/transplante
Plasma Rico em Plaquetas
Sobrevivência de Enxerto/fisiologia
-Valores de Referência
Crânio/patologia
Distribuição Aleatória
Sobrevivência Celular/fisiologia
Tecido Adiposo/irrigação sanguínea
Tecido Adiposo/patologia
Reprodutibilidade dos Testes
Resultado do Tratamento
Ratos Wistar
Modelos Animais
Limites: Animais
Feminino
Tipo de Publ: Estudos de Avaliação
Responsável: BR1.1 - BIREME


  3 / 1091 LILACS  
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Id: lil-787267
Autor: Brêtas, Salomão; Tatsuo, Edson Samesima; Brêtas, Monica Odete Oliveira; Brêtas, Caroline Oliveira.
Título: Measurement of testicular volume in Wistar rats using a caliper and ultrasonography in experimental surgery
Fonte: Acta cir. bras;31(7):479-485tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To compare the measurement of the testicular volume of Wistar rats using a caliper and ultrasonography. METHODS: Forty Wistar rats were randomly assigned into four groups. A tensile force of 1.6 Newton (N) and 1.0 N was applied to the right spermatic cord in group I and group II, respectively. Group III was the sham group, and group IV served as a control. The initial and final testicular volumes were measured using a caliper and ultrasonography and compared. A significance level of 5% was used. RESULTS: The Kappa coefficient was equal to 0.292 (p = 0.006). The Pearson correlation coefficient obtained for the percent reduction in the right testicular volume using ultrasonography and a caliper was equal to 0.696 (p < 0.001). CONCLUSION: There was reasonable agreement and a significant positive correlation between the percent reduction in the right testicular volume using ultrasonography and a caliper.
Descritores: Testículo/anatomia & histologia
Ultrassonografia/métodos
-Tamanho do Órgão
Cordão Espermático
Testículo/cirurgia
Testículo/diagnóstico por imagem
Tração/métodos
Distribuição Aleatória
Ratos Wistar
Modelos Animais
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  4 / 1091 LILACS  
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Módolo, Norma Sueli Pinheiro
Castiglia, Yara Marcondes Machado
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Id: lil-787265
Autor: Marques, Christiane D'Oliveira; Diego, Luis Antonio dos Santos; Marcondes-Machado, Jussara; Amorim, Renée Lauffer; Carvalho, Lídia Raquel; Módolo, Norma Sueli Pinheiro; Braz, Leandro Gobbo; Castiglia, Yara Marcondes Machado.
Título: Serum concentrations and renal expressions of IL-1 and TNF-a early after hemorrhage in rats under the effect of glibenclamide
Fonte: Acta cir. bras;31(7):434-441tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate changes in the serum concentration and renal expression of IL-1 and TNF-α cytokines in rats that received sevoflurane and glibenclamide prior to hemorrhage. METHODS: Two groups of sevoflurane-anesthetized Wistar rats (n=10): G1 (control) and G2 (glibenclamide, 1 µg/g i.v.); hemorrhage of 30% blood volume (10% every 10 min), with replacement using Ringer solution, 5 ml/kg/h. Serum concentrations of IL-1 and TNF-α were studied in the first hemorrhage (T1) and 50 min later (T2), renal expression, at T2. RESULTS: In serum, G1 TNF-α (pg/mL) was T1=178.6±33.5, T2=509.2±118.8 (p<0.05); IL-1 (pg/mL) was T1=148.8±31.3, T2=322.6±115.4 (p<0.05); in G2, TNF-α was T1=486.2±83.6, T2=261.8±79.5 (p<0.05); IL-1 was T1=347.0±72.0, T2= 327.3±90.9 (p>0.05). The expression of TNF-α and IL-1 in the glomerular and tubular cells was significantly higher in the G2 group. CONCLUSIONS: Hemorrhage and glibenclamide elevated TNF-α and IL-1 concentrations in serum and kidneys. High levels of TNF-α already present before the hemorrhage in the glibenclamide group may have attenuated the damages found in the kidneys after the ischemia event.
Descritores: Choque Hemorrágico/metabolismo
Interleucina-1/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Glibureto/farmacologia
Hipoglicemiantes/farmacologia
Rim/efeitos dos fármacos
-Peso Corporal/efeitos dos fármacos
Distribuição Aleatória
Ratos Wistar
Anestésicos Inalatórios/administração & dosagem
Modelos Animais
Canais KATP/antagonistas & inibidores
Rim/irrigação sanguínea
Rim/metabolismo
Túbulos Renais/efeitos dos fármacos
Túbulos Renais/metabolismo
Éteres Metílicos/administração & dosagem
Limites: Animais
Responsável: BR1.1 - BIREME


  5 / 1091 LILACS  
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Id: lil-787264
Autor: Burcu, Gul Baykalir; Osman, Ciftci; Aslı, Cetin; Namik, Oztanir Mustafa; Neşe, Basak Türkmen.
Título: The protective cardiac effects of Β-myrcene after global cerebral ischemia/reperfusion in C57BL/J6 mouse
Fonte: Acta cir. bras;31(7):456-462tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the protective effect of β-myrcene (MYR) on oxidative and histological damage in mice heart tissue caused global cerebral ischemia/reperfusion (IR) in C57BL/J6 mice. METHODS: Animals(n=40) were randomly divided into four groups: (1)control, (2)IR, (3)MYR and (4)MYR+IR. The control group was received 0.1% carboxymethyl cellulose as a vehicle following a medial incision without carotid occlusion. In the IR group, the bilateral carotid arteries were clipped for 15min, and treated with the vehicle intraperitoneally(ip) for 10 days. MYR (200mg/kg) was received dissolved in 0.1%CMC for 10 days. In the MYR+IR group, the IR model was applied exactly as in the IR group, and then they were treated with MYR 10 days. RESULTS: The cerebral IR caused oxidative damage (increase TBARS, decrease antioxidant parameters). Treatment of MYR was increased in GSH,GPx,CAT,SOD activity while TBARS level was decreased. In addition, degenerative changes in I/R group heart tissue were ameliorated by MYR administration. CONCLUSİON: The administration of β-myrcene protects oxidative and histological damage in the heart tissue after global ischemia-reperfusion and may be useful safe alternative treatment for cardiac tissue after ischemic stroke.
Descritores: Cardiotônicos/farmacologia
Traumatismo por Reperfusão/complicações
Isquemia Encefálica/complicações
Monoterpenos/farmacologia
Coração/efeitos dos fármacos
Antioxidantes/farmacologia
-Superóxido Dismutase/metabolismo
Catalase/metabolismo
Distribuição Aleatória
Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Modelos Animais
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Camundongos Endogâmicos C57BL
Miocárdio/metabolismo
Miocárdio/patologia
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  6 / 1091 LILACS  
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Id: lil-787263
Autor: Fantinati, Marcelo Silva; Mendonça, Diego Eterno Oliveira; Fantinati, Adriana Márcia Monteiro; Santos, Bruno Flamarion dos; Reis, Juliana Cristina Oliveira; Afonso, Cristina Lopes; Vinaud, Marina Clare; Lino Júnior, Ruy de Souza.
Título: Low intensity ultrasound therapy induces angiogenesis and persistent inflammation in the chronic phase of the healing process of third degree burn wounds experimentally induced in diabetic and non-diabetic rats
Fonte: Acta cir. bras;31(7):463-471tab, graf.
Idioma: en.
Projeto: FAPEG.
Resumo: ABSTRACT PURPOSE: To evaluate the effects of low intensity ultrasound on the healing process of third degree burn wounds in experimentally induced diabetic Wistar rats. METHODS: One hundred rats were divided into: control group; non-diabetic treated group; diabetic control group; diabetic treated group. The therapy was performed with a 3MHz ultrasound application, pulsed emission at 100Hz frequency, modulated at 20% with a dosage of 0.5W/cm2 during three minutes throughout 30 days. The surgical debridement of the wound was performed once at day 2. The wounds were morphometrically, macroscopically and microscopically evaluated at 3, 7, 14, 21 and 30 days. RESULTS: The wound contraction and collagen quantification were higher in all treated groups. Macroscopically, necrosis was higher in the diabetic control group. Granulation tissue was higher in treated groups during the proliferative and remodeling phase. Microscopically, there were greater mononuclear inflammatory infiltration, angiogenesis and fibroblast quantification in treated groups during the proliferative and remodeling phases. CONCLUSIONS: therapeutic ultrasound is beneficial in the inflammatory and proliferative phases of the healing process because it controlled the necrotic tissue, increased the granulation tissue and wound contraction. However in the remodeling phase it is not beneficial because of the continued angiogenesis and a mononuclear inflammatory infiltration.
Descritores: Pele/lesões
Terapia por Ultrassom/métodos
Cicatrização/fisiologia
Queimaduras/terapia
Indutores da Angiogênese/uso terapêutico
Diabetes Mellitus Experimental
-Queimaduras/patologia
Colágeno/análise
Ratos Wistar
Modelos Animais
Diabetes Mellitus Experimental/complicações
Diabetes Mellitus Experimental/terapia
Fibroblastos/patologia
Tecido de Granulação
Necrose/patologia
Necrose/reabilitação
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


  7 / 1091 LILACS  
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Braga, Angélica de Fátima de Assunçäo
Braga, Franklin Sarmento da Silva
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Id: lil-787260
Autor: Carvalho, Vanessa Henriques; Braga, Angélica de Fátima de Assunção; Braga, Franklin Sarmento da Silva; Potério, Gloria Maria Braga; Santos, Filipe Nadir Caparica; Junqueira, Fernando Eduardo Féres.
Título: Association between levobupivacaine and pancuronium. Interference in neuromuscular transmission and blockade in rats
Fonte: Acta cir. bras;31(7):486-489
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effects of levobupivacaine on neuromuscular transmission and neuromuscular blockade produced by pancuronium in vitro. METHODS: Thirty rats were distributed into groups (n = 5) according to the drug used alone or in combination: Group I - levobupivacaine (5 µg.mL-1); Group II - pancuronium (2 µg.mL-1); Group III - pancuronium (2 µg.mL-1) + levobupivacaine (5µg.mL-1). The following parameters were evaluated: 1) amplitude of diaphragmatic response to indirect stimulation, before and 60 minutes after the addition of levobupivacaine and pancuronium alone, and after the addition of levobupivacaine combined with pancuronium; 2) membrane potentials (MP) and miniature endplate potentials (MEPP). RESULTS: Levobupivacaine alone did not alter the amplitude of muscle response and MP. In preparations previoulsy exposed to levobupivacaine, the block with pancuronium was significantly denser (90.2 ± 15.2%), showing a significant difference (p=0.031) in comparison to the block produced by pancuronium alone (48.9% ± 9.8%). There was a decrease in the frequency and amplitude of MEPPs. CONCLUSION: Levobupivacaine potentiated the neuromuscular blockade produced by pancuronium, confirming a presynaptic action by a decrease in miniature endplate potentials.
Descritores: Pancurônio/farmacologia
Bupivacaína/análogos & derivados
Transmissão Sináptica/efeitos dos fármacos
Bloqueio Neuromuscular
Junção Neuromuscular/efeitos dos fármacos
-Bupivacaína/farmacologia
Diafragma/efeitos dos fármacos
Diafragma/inervação
Ratos Wistar
Fármacos Neuromusculares não Despolarizantes/farmacologia
Transmissão Sináptica/fisiologia
Modelos Animais
Quimioterapia Combinada
Estimulação Elétrica/métodos
Anestésicos Locais/farmacologia
Potenciais da Membrana/efeitos dos fármacos
Potenciais da Membrana/fisiologia
Junção Neuromuscular/fisiologia
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


  8 / 1091 LILACS  
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Czeczko, Nicolau Gregori
Malafaia, Osvaldo
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Id: lil-785021
Autor: Scheibe, Christian Lamar; Ribas-Filho, Jurandir Marcondes; Czeczko, Nicolau Gregori; Malafaia, Osvaldo; Barboza, Luiz Eduardo Durães; Ribas, Fernanda Marcondes; Wendler, Eduardo; Torres, Orlando; Lovato, Fernanda Christo; Scapini, João Guilherme Seifert.
Título: Schinus terebinthifolius raddi (Aroeira) and Orbignya phalerata mart. (Babassu) effect in cecorrahphy healing in rats
Fonte: Acta cir. bras;31(6):402-410tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the effect of Schinus terebinthifolius Raddi (aroeira) and Orbignya phalerata Mart. (babassu) in the healing process of cecorrhaphy in rats. METHODS : Fifty four rats were used, distributed into three groups randomly: aroeira, babassu and control, which were divided into three subgroups (six animals) according to the time of the deaths (7, 14, 21 days). All underwent the same surgical procedure, cecotomy and cecorrhaphy. The animals in group aroeira and babassu received daily dose of 100 mg/kg of hydroalcoholic extract and 50 mg/kg of aquous extract respectively, by gavage. The control group received only saline solution. The parameters evaluated were: macroscopic changes, ,resistance test to air insufflations and histological changes. RESULTS : All animals showed good healing without infection. All groups presented adhesions between cecum and neighboring organs. The resistance test insufflating of atmospheric air showed progressive increase of pressure according to the days in the aroeira group, and decrease in babassu group, without significant difference. Microscopy showed significant difference in the polymorphonuclear, hyperemia, angiogenesis, fibroblast proliferation and collagen histological variables in the 14th day. CONCLUSION : Hydroalcoholic extract of aroeira and the aqueous extract of babassu favored the healing process in cecorrhaphy in rats.
Descritores: Extratos Vegetais/farmacologia
Ceco/cirurgia
Anacardiaceae
Arecaceae
Fitoterapia
Anti-Inflamatórios/farmacologia
-Período Pós-Operatório
Distribuição Aleatória
Doenças do Ceco/prevenção & controle
Aderências Teciduais
Aderências Teciduais/etiologia
Ratos Wistar
Modelos Animais
Neutrófilos/efeitos dos fármacos
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME


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Id: lil-785020
Autor: Arslan, Ersoy; Irkorucu, Oktay; Sozutek, Alper; Cetinkunar, Suleyman; Reyhan, Enver; Yaman, Abit; Doran, Figen.
Título: The potential efficacy of Survanta (r) and Seprafilm (r) on preventing intra-abdominal adhesions in rats
Fonte: Acta cir. bras;31(6):389-395tab, graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To investigate the potential efficacy of beractant (Survanta(r)) and Seprafilm(r) on the prevention of postoperative adhesions. METHODS: Forty Wistar-albino female rats were used. The rats were randomly allocated into four groups of 10 rats each as control group (CG), beractant group (BG), Seprafilm(r) group (SG), and combined group (COG). All rats underwent cecal abrasion via midline laparotomy. Before abdominal closure, isotonic saline, beractant, Seprafilm, and combined agents were intraperitoneally administered. Adhesions were classified macroscopically with Canbaz Scoring System on postoperative day 10. Ceacum was resected for histopathological assessment. RESULTS: Macroscopic adhesion scores were significantly lower in BG, SG, and COG than CG (p<0.05); (45%, 15%, 25%, and 15%; respectively). Histopathological assessment revealed a reduced inflammation and fibrosis score in the study groups than CG (p<0.05). In BG, adhesion development, inflammation and fibrosis scores were lower than SG; however, it was not statistically significant. CONCLUSIONS: Intra-abdominal application of beractant is significantly effective for the prevention of adhesion formation with no adverse effect by covering the whole peritoneal mesothelium with excellent gliding properties in a rat model. The combination of both agents is also effective in reducing adhesion formation, however, not superior to single beractant application.
Descritores: Produtos Biológicos/farmacologia
Doenças do Ceco/prevenção & controle
Ceco/efeitos dos fármacos
Ácido Hialurônico/farmacologia
-Peritônio/efeitos dos fármacos
Peritônio/patologia
Cuidados Pós-Operatórios/instrumentação
Fibrose
Distribuição Aleatória
Ceco/cirurgia
Ceco/patologia
Aderências Teciduais/patologia
Aderências Teciduais/prevenção & controle
Ratos Wistar
Modelos Animais
Quimioterapia Combinada/métodos
Inflamação/patologia
Inflamação/prevenção & controle
Limites: Animais
Feminino
Responsável: BR1.1 - BIREME


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Id: lil-785017
Autor: Romero, Gustavo Tominaga; Santos, Carlos Henrique Marques dos; Cassino, Pedro Carvalho; Odashiro, Maçanori; Seno, Gisele Zocoller; Aléssio, Gabriela Flávia.
Título: Treatment of fistula-in-ano with cyanoacrylate glue with and without prior seton placement in rats
Fonte: Acta cir. bras;31(6):377-381graf.
Idioma: en.
Resumo: ABSTRACT PURPOSE: To evaluate the efficacy of ethyl-cyanoacrylate in the treatment of fístula-in-ano in rats with and without prior seton placement. METHODS: Thirty rats Wistar with fístula-in-ano produced surgically, distributed in three groups: group A (ethyl-cyanoacrylate) - treated by application of ethyl-cyanoacrylate into fístula tract; group B (seton + ethyl-cyanoacrylate) - seton placement followed by application of ethyl-cyanoacrylate into fístula tract, 30 days later; group C (control) - no treatment. After 60 days the animals were submited to euthanasia and the specimens were analyzed by pathologist. The results were analyzed by Chi-square test with significant value of p<0.05. RESULTS: One animal of group B died. Were found tracts fully healed: 7, 5 and 2, in groups A, B and C, respectivelly. There was a statistically significant difference between groups A and C (p=0.02). When joined all animals treated with glue (A + B) compared to group C there was also statistically significant difference (p=0.02). CONCLUSIONS: The use of ethyl-cyanoacrylate glue was effective in closing anal fistulae in rats. There was no advantage in the prior application of seton.
Descritores: Adesivos Teciduais/uso terapêutico
Drenagem/métodos
Fístula Retal/tratamento farmacológico
Cianoacrilatos/uso terapêutico
-Período Pós-Operatório
Fístula Retal/cirurgia
Resultado do Tratamento
Ratos Wistar
Terapia Combinada/métodos
Modelos Animais
Limites: Animais
Masculino
Responsável: BR1.1 - BIREME



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