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Magalhäes, Luiz Augusto
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Id: lil-623720
Autor: Magalhães, Luiz Augusto.
Título: Relevant problems to the epidemiology of mansonic schistosomiasis
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):341-341, 1987.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Schistosoma mansoni/fisiologia
Biomphalaria/parasitologia
Vetores de Doenças
-Esquistossomose mansoni/transmissão
Brasil
Quimiotaxia
Responsável: BR1.1 - BIREME


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Id: biblio-836849
Autor: Sant'Ana, Adriana Campos Passanezi; Passanezi, Euloir; Rezende, Maria Lúcia Rubo de; Greghi, Sebastião Luiz Aguiar.
Título: Papel dos fatores de crescimento na regeneração periodontal: estado atual da arte / The role of growth factors in periodontal regeneration: current state-of-the-art
Fonte: Perionews;1(2):133-140, abr.-jun. 2007. ilus, tab.
Idioma: pt.
Resumo: Fatores de crescimento polipeptídicos são proteínas de baixo peso molecular sintetizadas por várias células e tecidos que regulam os eventos básicos que levam à regeneração periodontal: proliferação, quimiotaxia, diferenciação e síntese de matriz protéica. Embora diversos métodos terapêuticos tenham sido propostos para uso clínico visando a regeneração dos tecidos periodontais, a previsibilidade de sucesso ainda é limitada, com casos bem-sucedidos e outros mostrando resultados aquém do esperado. Recentemente, após a identificação da existência de células tronco no ligamento periodontal e a compreensão que a diferenciação destas células em outras mais diferenciadas (fibroblastos, osteoblastos e cementoblastos) é mediada por moléculas de sinalização (fatores de crescimento), alguns estudos foram publicados propondo a utilização clínica dos fatores de crescimento, isolados ou combinados, em diferentes tipos de veículos com o objetivo de favorecer a regeneração periodontal. Neste artigo, as características gerais e os estudos in vitro e in vivo evidenciando o papel dos principais fatores de crescimento utilizados na regeneração periodontal serão revistos com o objetivo de avaliar o papel dos fatores de crescimento na regeneração periodontal.

Polipeptidic growth factors are low density proteins secreted by different cells and tissues that regulate the basic events leading to periodontal regeneration: proliferation, chemotaxis, differentiation and protein synthesis. Although many methods for achieving regeneration of lost periodontal tissues have been suggested, there is poor predictability, with some well-succeeded cases and others showing unexpected results. Recently, after the identification of mesenchymal stem cells in the periodontal ligament and the understanding that the differentiation of these cells onto more differentiated ones (osteoblasts, cementoblasts, fibroblasts) is mediated by signaling molecules (growth factors), some studies have proposed the clinical use of growth factors isolated or in combination to enhance periodontal regeneration outcomes. In this paper, the characteristics and in vitro and the in vivo studies evaluating the role of growth factors in periodontal regeneration will be reviewed to evaluate the role of growth factors in periodontal regeneration.
Descritores: Quimiotaxia
Regeneração Tecidual Guiada Periodontal
Peptídeos e Proteínas de Sinalização Intercelular
Mitógenos
Periodontia
Limites: Seres Humanos
Tipo de Publ: Revisão
Responsável: BR510.1 - Biblioteca Central


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Texto completo SciELO Brasil
Texto completo
Id: lil-751309
Autor: Pereira, Elisângela Vitoriano; Costa, Jorge de Assis; Alfenas, Rita de Cássia Gonçalves.
Título: Effect of glycemic index on obesity control
Fonte: Arch. endocrinol. metab. (Online);59(3):245-251, 06/2015. tab, graf.
Idioma: en.
Resumo: Objective Evaluate the effect of glycemic index (GI) on biochemical parameters, food intake, energy metabolism, anthropometric measures and body composition in overweight subjects.Materials and methods Simple blind study, in which nineteen subjects were randomly assigned to consume in the laboratory two daily low GI (n = 10) or high GI (n = 9) meals, for forty-five consecutive days. Habitual food intake was assessed at baseline. Food intake, anthropometric measures and body composition were assessed at each 15 days. Energy metabolism and biochemical parameters were evaluated at baseline and the end of the study.Results Low GI meals increased fat oxidation, and reduced waist circumference and HOMA-IR, while high GI meals increased daily dietary fiber and energy intake compared to baseline. There was a higher reduction on waist circumference and body fat, and a higher increase on postprandial fat oxidation in response to the LGI meals than after high GI meals. High GI meals increased fasting respiratory coefficient compared to baseline and low GI meals.Conclusion The results of the present study showed that the consumption of two daily low GI meals for forty-five consecutive days has a positive effect on obesity control, whereas, the consumption of high GI meals result has the opposite effect. Arch Endocrinol Metab. 2015;59(3):245-51.
Descritores: Proteínas de Bactérias/química
Escherichia coli/enzimologia
Proteínas de Membrana/química
Fenilalanina/química
-Motivos de Aminoácidos
Sequência de Aminoácidos
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Quimiotaxia
Sequência Conservada
Dimerização
Escherichia coli/química
Escherichia coli/genética
Escherichia coli/fisiologia
Dados de Sequência Molecular
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Conformação Proteica
Fenilalanina/genética
Fenilalanina/metabolismo
Tipo de Publ: Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Responsável: BR1.1 - BIREME


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Texto completo
Id: lil-735848
Autor: Zhong, Z.X.; Li, B.; Li, C.R.; Zhang, Q.F.; Liu, Z.D.; Zhang, P.F.; Gu, X.F.; Luo, H.; Li, M.J.; Luo, H.S.; Ye, G.H.; Wen, F.L..
Título: Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;48(2):161-166, 02/2015. tab, graf.
Idioma: en.
Resumo: Our aim was to investigate the role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism. Coronary angiography and intravascular ultrasound (IVUS) were performed in 60 stable angina pectoris (SAP) patients and 60 unstable angina pectoris (UAP) patients. The chemotactic activity of monocytes in the 2 groups of patients was examined in Transwell chambers. High-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1), regulated on activation in normal T-cell expressed and secreted (RANTES), and fractalkine in serum were examined with ELISA kits, and expression of MCP-1, RANTES, and fractalkine mRNA was examined with real-time PCR. In the SAP group, 92 plaques were detected with IVUS. In the UAP group, 96 plaques were detected with IVUS. The plaques in the UAP group were mainly lipid 51.04% (49/96) and the plaques in the SAP group were mainly fibrous 52.17% (48/92). Compared with the SAP group, the plaque burden and vascular remodeling index in the UAP group were significantly greater than in the SAP group (P<0.01). Chemotactic activity and the number of mobile monocytes in the UAP group were significantly greater than in the SAP group (P<0.01). Concentrations of hs-CRP, MCP-1, RANTES, and fractalkine in the serum of the UAP group were significantly higher than in the serum of the SAP group (P<0.05 or P<0.01), and expression of MCP-1, RANTES, and fractalkine mRNA was significantly higher than in the SAP group (P<0.05). MCP-1, RANTES, and fractalkine probably promote instability of coronary atherosclerotic plaque.
Descritores: Angina Pectoris/metabolismo
Quimiocinas/metabolismo
Quimiotaxia/fisiologia
Doença da Artéria Coronariana/metabolismo
Monócitos/metabolismo
Placa Aterosclerótica/fisiopatologia
-Angina Pectoris/fisiopatologia
Proteína C-Reativa/análise
/sangue
CHEMOKINE CCLABDOMEN/sangue
/sangue
CHEMOKINE CCLTEMEFOS/sangue
/sangue
CHEMOKINE CXABATTOIRSCL1/sangue
Doença da Artéria Coronariana/fisiopatologia
Reação em Cadeia da Polimerase em Tempo Real
Ultrassonografia de Intervenção
Limites: Adulto
Feminino
Seres Humanos
Masculino
Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-682593
Autor: Carlone, Robert; Dmetrichuk, Jennifer; Carter , Christopher; Spencer, Gaynor.
Título: Retinoids in development and regeneration in the CNS of vertebrates and invertebrates
Fonte: In: II International Congress on Neuroregeneration. Proceedings (selected papers). Rio de Janeiro, UFRJ, 2004. p.51-57, ilus.
Idioma: en.
Conferência: Apresentado em: International Congress on Neuroregeneration, 2, Rio de Janeiro, 2004.
Resumo: Retinoic acid (RA) is a biologically important metabolite of vitamin A that modulates growth and differentiation of many cell types. Although abundant in the CNS of many vertebrates, the precise role of RA in neural development has yet to be elucidated. Moreover, very little information is available regarding the role of RA in invertebrate neural development and regeneration. We have recently demonstrated that RA stimulates neurite outgrowth from adult newt spinal cord explants and may represent a significant factor in vivo in the reciprocal interactions between peripheral nerves and regenerating limb blastema cells. This interaction leads to the restoration of a functional limb after amputation. In support of this model, we have cloned a cDNA for the retinoic acid receptor of the β subtype (RARβ) whose expression is restricted to the spinal cord and brain of the adult newt and may be present in the limb blastema. This receptor may mediate the trophic effects of blastema-derived RA on neurite outgrowth and chemotaxis from spinal cord neurons. We have also extended our studies on the role of RA to the simple nervous system of the mollusc, Lymnaea stagnalis. Preliminary data support a role for RA in the survival, outgrowth, and chemotactic response of single, isolated, identifiable neurons in culture. This work represents the first evidence for chemotaxis and trophic effects of retinoids in an invertebrate nervous system. It is hoped that our work will shed light on the evolutionary conservation of a role for RA in neural development and regeneration.
Descritores: Sistema Nervoso Central
Quimiotaxia
Invertebrados
Moluscos
Neurônios
Salamandridae
Coluna Vertebral
Tretinoína
Vertebrados
Vitamina A
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM
BR408.1; 616.8, P963, 2004


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Id: lil-634680
Autor: D´Ippólito, Sebastián; de Castro, Rosana E.; Herrera Seitz, Karina.
Título: Chemotactic responses to gas oil of Halomonas spp. strains isolated from saline environments in Argentina / Respuesta quimiotáctica hacia gas oil de cepas de Halomonas spp. aisladas de ambientes salinos de Argentina
Fonte: Rev. argent. microbiol;43(2):107-110, jun. 2011. ilus, graf.
Idioma: en.
Resumo: In this study, two halophilic bacterial strains isolated from saline habitats in Argentina grew in the presence of gas oil. They were identified as Halomonas spp. and Nesterenkonia sp. by 16S ribosomal RNA sequencing. Chemotaxis towards gas oil was observed in Halomonas spp. by using swimming assays.

En el presente trabajo se aislaron dos cepas bacterianas halofílicas a partir de muestras obtenidas en ambientes salinos de Argentina, que crecieron en presencia de gasoil como única fuente de carbono. Las cepas aisladas se identificaron como Halomonas spp. y Nesterenkonia sp. mediante secuenciación del gen del ARN ribosomal 16S. En ensayos de swimming, las cepas del genero Halomonas spp. mostraron una respuesta quimiotáctica hacia el gas oil.
Descritores: Quimiotaxia/efeitos dos fármacos
Halomonas/efeitos dos fármacos
Micrococcaceae/efeitos dos fármacos
Petróleo
-Argentina
Biodegradação Ambiental
Hidrocarbonetos
Halomonas/crescimento & desenvolvimento
Halomonas/isolamento & purificação
Micrococcaceae/crescimento & desenvolvimento
Micrococcaceae/isolamento & purificação
Ribotipagem
Tolerância a Sal
Especificidade da Espécie
Água do Mar/microbiologia
Microbiologia da Água
Poluentes Químicos da Água
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: AR1.2 - Instituto de Investigaciónes Epidemiológicas


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Texto completo SciELO Chile
Texto completo
Id: lil-608624
Autor: Cerda, Oscar A; Núñez-Villena, Felipe; Soto, Sarita E; Ugalde, José Manuel; López-Solís, Remigio; Toledo, Héctor.
Título: tlpA gene expression is required for arginine and bicarbonate chemotaxis in Helicobacter pylori
Fonte: Biol. Res;44(3):277-282, 2011. ilus, tab.
Idioma: en.
Projeto: FONDECYT.
Resumo: About half of the human population is infected with Helicobacter pylori, a bacterium causing gastritis, peptic ulcer and progression to gastric cancer. Chemotaxis and flagellar motility are required for colonization and persistence of H. pylori in the gastric mucus layer. It is not completely clear which chemical gradients are used by H. pylori to maintain its position. TlpA, a chemotaxis receptor for arginine/ bicarbonate, has been identified. This study aimed to find out whether tlpA gene expression is required for the chemotactic response to arginine/bicarbonate. Wild-type motile H. pylori ATCC 700392 and H. pylori ATCC 43504, a strain having an interrupted tlpA gene, were used. Also, a tlpA-knockout mutant of H. pylori 700392 (H. pylori 700-tlpA::cat) was produced by homologous recombination. Expression of tlpA was assessed by a Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR) assay. Chemotaxis was measured as a Relative Chemotaxis Response (RCR) by a modified capillary assay. H. pylori 700392 presented chemotaxis to arginine and sodium bicarbonate. H. pylori 700-tlpA::cat showed neither tlpA gene expression nor chemotaxis towards arginine and bicarbonate. Besides confirming that TlpA is a chemotactic receptor for arginine/bicarbonate in H. pylori, this study showed that tlpA gene expression is required for arginine/bicarbonate chemotaxis.
Descritores: Arginina/farmacologia
Proteínas de Bactérias/genética
Bicarbonatos/farmacologia
Quimiotaxia/genética
Helicobacter pylori/genética
Proteínas de Membrana/genética
-Expressão Gênica
Helicobacter pylori/efeitos dos fármacos
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Transdução de Sinais
Ureia/metabolismo
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo
Id: lil-597730
Autor: Ortiz, Mario Iván; Suárez-Rivillas, Alejandro; Molina, Jorge.
Título: Behavioural responses to human skin extracts and antennal phenotypes of sylvatic first filial generation and long rearing laboratory colony Rhodnius prolixus: [erratum]
Fonte: Mem. Inst. Oswaldo Cruz;106(5), Aug. 2011.
Idioma: en.
Descritores: Antenas de Artrópodes/fisiologia
Comportamento Animal/fisiologia
Insetos Vetores/fisiologia
Feromônios
Rhodnius/fisiologia
Pele
-Animais de Laboratório
Antenas de Artrópodes
Antenas de Artrópodes/ultraestrutura
Células Quimiorreceptoras/fisiologia
Quimiotaxia/fisiologia
Face

Fenótipo
Rhodnius
Extratos de Tecidos
Limites: Animais
Feminino
Seres Humanos
Masculino
Tipo de Publ: Errata
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo
Id: lil-592190
Autor: Ortiz, Mario Iván; Suárez-Rivillas, Alejandro; Molina, Jorge.
Título: Behavioural responses to human skin extracts and antennal phenotypes of sylvatic first filial generation and long rearing laboratory colony Rhodnius prolixus
Fonte: Mem. Inst. Oswaldo Cruz;106(4):461-466, June 2011. ilus, graf, tab.
Idioma: en.
Resumo: Chagas disease is a major public health issue and is mainly spread by Triatominae insects (Hemiptera: Reduviidae). Rhodnius prolixus is the main vector species in Northern South America. Host-seeking behaviour in R. prolixus is mediated by different compounds that are produced by and emanate from the host or microbiota on the host's skin. We tested the behavioural responses of sylvatic first filial generation (F1) and colony insects to extracts of human skin with a dual choice olfactometer. In addition, we compared the antennal phenotypes in both populations. No statistical differences were found between the two populations at the behavioural level. Both showed a preference for face and feet extracts and this effect was abolished for face extracts after treatment with an antibacterial gel. The observation of the antennal phenotype showed that there were differences between both groups in the total length, total surface area and number and density of bristles. However, the number and density of chemoreceptive sensilla (basiconic and thin and thick-walled trichoids) and the total density of sensilla did not show statistically significant differences. These results demonstrate that colony insects, which have only been fed with living hens for the last 30 years, are attracted by human skin extracts in a similar way as F1 sylvatic insects.
Descritores: Antenas de Artrópodes/fisiologia
Comportamento Animal/fisiologia
Insetos Vetores/fisiologia
Feromônios
Rhodnius/fisiologia
Pele
-Animais de Laboratório
Antenas de Artrópodes
Antenas de Artrópodes/ultraestrutura
Células Quimiorreceptoras/fisiologia
Quimiotaxia/fisiologia
Face

Fenótipo
Rhodnius
Extratos de Tecidos
Limites: Animais
Feminino
Seres Humanos
Masculino
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-587428
Autor: Neves, Fabrício de Souza.
Título: Expressão de receptores toll-like 2 e função quimiotáxica de neutrófilos na doença de Behçet / Expression of toll-like receptor 2 and neutrophil chemotaxis in Behçet´s disease.
Fonte: São Paulo; s.n; 2009. [114] p. graf.
Idioma: pt.
Tese: Apresentada a Universidade de São Paulo. Faculdade de Medicina para obtenção do grau de Doutor.
Resumo: A doença de Behçet tem sua fisiopatologia caracterizada por hiperatividade neutrofílica, particularmente em relação à quimiotaxia, e períodos de atividade da doença podem ser desencadeados por exposição a estreptococos. Uma vez que células do sistema imune inato são ativadas pelo ácido lipoteicoico (LTA) de bactérias gram-positivas via receptor toll-like (TLR) 2 e CD14, cujas expressões são reguladas pelos fatores estimulantes de colônias de granulócitos (G-CSF) e granulócitos-macrófagos (GM-CSF), o objetivo principal deste estudo foi determinar se há hiperexpressão de TLR2 em neutrófilos de DB ativa e se a quimiotaxia de polimorfonucleares (PMN) neutrófilos na DB poderia ser hiperestimulada pelo LTA. Além do TLR2, foram medidas as expressões de TLR4, CD14, CD114 (receptor de G-CSF) e CD116 (receptor de GM-CSF) nos neutrófilos e nos monócitos de pacientes com doença de Behçet (DB), as concentrações séricas de CD14 solúvel (CD14s) e as respostas quimiotáxicas dos PMNs de DB sob diferentes estímulos. A expressão dos receptores foi medida pela citometria de fluxo, as concentrações séricas por ELISA e as respostas quimiotáxicas foram avaliadas em câmara de Boyden. Nos PMNs, os receptores foram igualmente expressos nos dois grupos e, estimulados com LTA, suas respostas quimiotáxicas também foram similares. Somente à incubação com plasma os PMNs de DB desenvolveram hiperquimiotaxia em relação aos PMNs controles. A expressão do TLR2 foi maior em monócitos de DB em relação aos controles, e a concentração de CD14s sérica, de origem monocitária, foi maior nos pacientes com DB ativa. Em conjunto, os resultados demonstram que PMNs de DB, isoladamente, não reagem exacerbadamente ao LTA, e suas respostas migratórias são estritamente dependentes de fatores estimulantes solúveis.

Expressions of toll-like receptor (TLR) 2, TLR4, CD14, CD114 and CD116 were assessed on polymorphonuclear (PMN) neutrophils and monocytes of patients with Behçets disease (BD). PMN chemotactic responses under different stimulations were also measured. The objective was to determine if BD PMN chemotaxis may be overstimulated by lipoteichoic acid (LTA) from gram-positive bacteria. Receptor expressions were measured by flow cytometry and PMN chemotaxis was assessed in a Boyden chamber. Only TLR2 expression was higher on monocytes of the BD group than in control group. On PMNs, however, TLR2 expression was similar in both groups and, when stimulated with LTA, BD PMN cells showed chemotactic responses similar to the controls. These cells only exhibited increased chemotaxis when incubated with plasma. In conclusion, isolated BD PMN did not overreact to LTA, and its hyperchemotaxis is strictly dependent on soluble stimulating factors.
Descritores: ANTIGENOS CDCONGENITAL ABNORMALITIES
Quimiotaxia
Monócitos
Neutrófilos
RECEPTOR ABBREVIATIONS AS TOPIC TOLL-LIKE
RECEPTOR TEMEFOS TOLL-LIKE
Síndrome de Behçet/fisiopatologia
Limites: Seres Humanos
Masculino
Feminino
Responsável: BR66.1 - Divisão de Biblioteca e Documentação
BR66.1; W4.DB8, N424ex, FM-2, 2009



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