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Consolaro, Alberto
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Id: lil-745862
Autor: Consolaro, Alberto.
Título: Orthodontic movement in deciduous teeth
Fonte: Dental press j. orthod. (Impr.);20(2):16-19, Mar-Apr/2015. graf.
Idioma: en.
Resumo: Deciduous teeth exfoliate as a result of apoptosis induced by cementoblasts, a process that reveals the mineralized portion of the root while attracting clasts. Root resorption in deciduous teeth is slow due to lack of mediators necessary to speed it up; however, it accelerates and spreads in one single direction whenever a permanent tooth pericoronal follicle, rich in epithelial growth factor (EGF), or other bone resorption mediators come near. The latter are responsible for bone resorption during eruption, and deciduous teeth root resorption and exfoliation. Should deciduous teeth be subjected to orthodontic movement or anchorage, mediators local levels will increase. Thus, one should be fully aware that root resorption in deciduous teeth will speed up and exfoliation will early occur. Treatment planning involving deciduous teeth orthodontic movement and/or anchorage should consider: Are clinical benefits relevant enough as to be worth the risk of undergoing early inconvenient root resorption?.

O dente decíduo é esfoliado graças à apoptose em seus cementoblastos, que desnuda a parte mineralizada da raiz e atrai os clastos. A rizólise é lenta, pois faltam mediadores em quantidade para acelerar o processo, mas ela se acelera e unidireciona quando se aproxima um folículo pericoronário de dente permanente rico em EGF e outros mediadores da reabsorção óssea - os responsáveis pelas reabsorções óssea na erupção e dentária decídua na rizólise e esfoliação. Se houver movimentação ortodôntica ou ancoragem em dentes decíduos, aumenta-se, também, o nível local desses mesmos mediadores, devendo-se estar bem consciente de que haverá uma aceleração da rizólise e, em decorrência, uma antecipação de sua esfoliação. No planejamento de casos em que dentes decíduos estejam envolvidos na movimentação ortodôntica e/ou ancoragem, deve-se ponderar: o benefício clínico para o paciente será relevante, a ponto de valer o risco de uma rizólise abreviada e inconveniente?.
Descritores: Dente Decíduo/fisiologia
Técnicas de Movimentação Dentária/métodos
-Reabsorção da Raiz/fisiopatologia
Erupção Dentária/fisiologia
Esfoliação de Dente/fisiopatologia
Reabsorção Óssea/fisiopatologia
Quimiotaxia/fisiologia
Apoptose/fisiologia
Peptídeos e Proteínas de Sinalização Intercelular/fisiologia
Cemento Dentário/fisiologia
Saco Dentário/citologia
Saco Dentário/fisiologia
Fator de Crescimento Epidérmico/fisiologia
Células Epiteliais/fisiologia
Procedimentos de Ancoragem Ortodôntica/métodos
Odontoblastos/fisiologia
Limites: Humanos
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: biblio-950754
Autor: Ortiz, Gustavo; Salica, Juan P; Chuluyan, Eduardo H; Gallo, Juan E.
Título: Diabetic retinopathy: could the alpha-1 antitrypsin be a therapeutic option?
Fonte: Biol. Res;47:1-9, 2014. ilus, tab.
Idioma: en.
Resumo: Diabetic retinopathy is one of the most important causes of blindness. The underlying mechanisms of this disease include inflammatory changes and remodeling processes of the extracellular-matrix (ECM) leading to pericyte and vascular endothelial cell damage that affects the retinal circulation. In turn, this causes hypoxia leading to release of vascular endothelial growth factor (VEGF) to induce the angiogenesis process. Alpha-1 antitrypsin (AAT) is the most important circulating inhibitor of serine proteases (SERPIN). Its targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, proteinase 3 (PR-3) and plasminogen activator (PAI). AAT modulates the effect of protease-activated receptors (PARs) during inflammatory responses. Plasma levels of AAT can increase 4-fold during acute inflammation then is so-called acute phase protein (APPs). Individuals with low serum levels of AAT could develop disease in lung, liver and pancreas. AAT is involved in extracellular matrix remodeling and inflammation, particularly migration and chemotaxis of neutrophils. It can also suppress nitric oxide (NO) by nitric oxide sintase (NOS) inhibition. AAT binds their targets in an irreversible way resulting in product degradation. The aim of this review is to focus on the points of contact between multiple factors involved in diabetic retinopathy and AAT resembling pleiotropic effects that might be beneficial.
Descritores: Inibidores de Serino Proteinase/uso terapêutico
alfa 1-Antitripsina/uso terapêutico
Retinopatia Diabética/tratamento farmacológico
-Hipóxia Celular
Inibidores de Serino Proteinase/metabolismo
Movimento Celular/fisiologia
Quimiotaxia/fisiologia
alfa 1-Antitripsina/metabolismo
NF-kappa B/metabolismo
Fator de Necrose Tumoral alfa/metabolismo
Mediadores da Inflamação/antagonistas & inibidores
Óxido Nítrico Sintase/antagonistas & inibidores
Substâncias Protetoras/metabolismo
Receptores Ativados por Proteinase/metabolismo
Retinopatia Diabética/fisiopatologia
Radicais Livres
Inflamação/metabolismo
Anti-Inflamatórios/metabolismo
Anti-Inflamatórios/uso terapêutico
Neutrófilos/fisiologia
Limites: Humanos
Animais
Tipo de Publ: Revisão
Responsável: CL1.1 - Biblioteca Central


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Id: biblio-1041561
Autor: Tee, Ling Fei; Tan, Toh Leong; Neoh, Hui-min; Jamal, Rahman.
Título: Rapid detection of sepsis using cesda: the caenorhabditis elegans sepsis detection assay
Fonte: Rev. Soc. Bras. Med. Trop;52:e20180300, 2019. tab, graf.
Idioma: en.
Projeto: Young Researcher Grant; . Universiti Kebangsaan Malaysia.
Resumo: Abstract INTRODUCTION The nematode Caenorhabditis elegans was used as a biological sensor to detect the urine of sepsis patients (CESDA assay). METHODS C. elegans was aliquoted onto the center of assay plates and allowed to migrate towards sepsis (T) or control (C) urine samples spotted on the same plate. The number of worms found in either (T) or (C) was scored at 10-minute intervals over a 60-minute period. RESULTS The worms were able to identify the urine (<48 hours) of sepsis patients rapidly within 20 minutes (AUROC=0.67, p=0.012) and infection within 40 minutes (AUROC=0.80, p=0.016). CONCLUSIONS CESDA could be further explored for sepsis diagnosis.
Descritores: Biomarcadores/urina
Quimiotaxia
Caenorhabditis elegans
Sepse/diagnóstico
-Fatores de Tempo
Sensibilidade e Especificidade
Sepse/urina
Limites: Humanos
Animais
Responsável: BR1.1 - BIREME


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Texto completo SciELO Chile
Texto completo
Id: biblio-950898
Autor: Diao, Ruiying; Cai, Xueyong; Liu, Lu; Yang, Lihua; Duan, YongGang; Cai, Zhiming; Gui, Yaoting; Mou, Lisha.
Título: In vitro chemokine (C-C motif) receptor 6-dependent non-inflammatory chemotaxis during spermatogenesis
Fonte: Biol. Res;51:12, 2018. graf.
Idioma: en.
Projeto: National Natural Science Foundation of China; . Guangdong Natural Science Foundation; . Shenzhen Foundation of Science and Technology; . Medical Scientific Research Foundation of Guangdong.
Resumo: BACKGROUND: Chemokine (C-C motif) receptor 6 (CCR6) is present in sperm and plays a significant role in sperm motility and chemotaxis acting in the reproductive tracts. However, the expression and functional significance of CCR6 in testis are still poorly understood, especially in the process of spermatogenesis. METHODS AND RESULTS: CCR6 was expressed in spermatogenic cell lines and its expression was shown in an age-dependent upregulation manner from puberty to adulthood in mouse testis. Immunostaining results confirmed the localization of CCR 6 in testis. Further chemotaxis assays demonstrated that spermatogenic cells GC-1 and -2 exhibited a directional movement toward CCR6-specific ligand such as CCL20 or Sertoli cells in vitro. CONCLUSIONS: The present findings indicate that CCR6 is involved in the chemotaxis of spermatogenic cells in vitro and promotes chemotaxis under non-inflammatory conditions during normal spermatogenesis.
Descritores: Espermatogênese/fisiologia
Quimiotaxia/fisiologia
Criptorquidismo/metabolismo
Quimiocina CCL20/metabolismo
Receptores CCR6/metabolismo
-Células de Sertoli
Motilidade Espermática/fisiologia
Testículo/fisiologia
Imuno-Histoquímica
Western Blotting
Imunofluorescência
Camundongos Endogâmicos C57BL
Limites: Humanos
Animais
Masculino
Camundongos
Coelhos
Responsável: CL1.1 - Biblioteca Central


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Texto completo
Id: biblio-888739
Autor: Simões, L F; Bastos, L D B; Camargo, E A F; Neves, M F; Linhares, A X; Magalhães, L A; Zanotti-Magalhães, E M.
Título: Host-parasite relationship between Biomphalaria amazonica (Paraense, 1966) and Schistosoma mansoni (Sambon, 1907) / Relação parasito-hospedeiro entre Biomphalaria amazonica e Schistosoma mansoni
Fonte: Braz. j. biol;77(2):340-346, Apr.-June 2017. tab, graf.
Idioma: en.
Resumo: Abstract Biomphalaria amazonica is a planorbid species considered a potential host of Schistosoma mansoni. It is widely distributed in the Neotropical zone, particularly in the North and Centre-West of Brazil and in the North of Bolivia. The aim of the present study was to determine the host-parasite relationship between B. amazonica and S. mansoni (BH and SJ strains). Specimens of B. amazonica and their snail-conditioned water were examined in terms of their ability to attract miracidia. The infectivity of the mollusks was determined by exposing them to 20 miracidia of both strains. Sporocyst development and amebocyte reactions were studied after each mollusk specimen was exposed to 100 miracidia. Although no cercariae were eliminated, specimens of B. amazonica proved capable of attracting 77% of the miracidia they were exposed to. Viable sporocysts with no amebocyte reaction were found 96 hours after the exposure to miracidia. These results indicate the susceptibility of B. amazonica to the BH and SJ strains of S. mansoni, and therefore demonstrate the importance of this planorbid species as a potential vector of the trematode in the areas where it occurs.

Resumo Biomphalaria amazonica é uma espécie de planorbídeo considerada vetora potencial do Schistosoma mansoni. É amplamente distribuída na zona neotropical, especialmente no Norte e Centro-Oeste do Brasil e Norte da Bolívia. O presente trabalho teve por objetivo estudar a relação parasito-hospedeiro entre B. amazonica e S. mansoni (linhagens BH e SJ). Espécimes de B. amazonica e sua água de condicionamento foram examinados em relação à sua capacidade de atração miraxonal. A infectividade dos moluscos foi testada expondo-os a 20 miracídios de ambas as linhagens. A viabilidade dos esporocistos e o desenvolvimento de reações amebocitárias foram estudados após cada molusco ser exposto a 100 miracídios. Apesar de não eliminarem cercárias, B. amazonica provou ser capaz de atrair 77% dos miracídios a que foram expostos. Esporocistos viáveis sem reação amebócitaria foram encontrados 96 horas após a exposição aos miracídios. Esses resultados indicam a suscetibilidade de B. amazonica às linhagens BH e SJ de S. mansoni e, portanto, demonstram a importância desta espécie de planorbídeo como um vetor potencial do trematodeo na área onde ele ocorre.
Descritores: Schistosoma mansoni/fisiologia
Biomphalaria/parasitologia
Interações Hospedeiro-Parasita
-Schistosoma mansoni/crescimento & desenvolvimento
Brasil
Quimiotaxia
Oocistos/crescimento & desenvolvimento
Oocistos/fisiologia
Cercárias/crescimento & desenvolvimento
Cercárias/fisiologia
Limites: Animais
Responsável: BR1.1 - BIREME


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Magalhäes, Luiz Augusto
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Id: lil-623720
Autor: Magalhães, Luiz Augusto.
Título: Relevant problems to the epidemiology of mansonic schistosomiasis
Fonte: Mem. Inst. Oswaldo Cruz;82(supl.4):341-341, 1987.
Idioma: en.
Conferência: Apresentado em: International Symposium on Schistosomiasis, Apresentado em: Reunião Nacional de Esquistossomose, 1, Rio de Janeiro, Oct. 25-30, 1987.
Descritores: Schistosoma mansoni/fisiologia
Biomphalaria/parasitologia
Vetores de Doenças
-Esquistossomose mansoni/transmissão
Brasil
Quimiotaxia
Responsável: BR1.1 - BIREME


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Id: biblio-836849
Autor: Sant'Ana, Adriana Campos Passanezi; Passanezi, Euloir; Rezende, Maria Lúcia Rubo de; Greghi, Sebastião Luiz Aguiar.
Título: Papel dos fatores de crescimento na regeneração periodontal: estado atual da arte / The role of growth factors in periodontal regeneration: current state-of-the-art
Fonte: Perionews;1(2):133-140, abr.-jun. 2007. ilus, tab.
Idioma: pt.
Resumo: Fatores de crescimento polipeptídicos são proteínas de baixo peso molecular sintetizadas por várias células e tecidos que regulam os eventos básicos que levam à regeneração periodontal: proliferação, quimiotaxia, diferenciação e síntese de matriz protéica. Embora diversos métodos terapêuticos tenham sido propostos para uso clínico visando a regeneração dos tecidos periodontais, a previsibilidade de sucesso ainda é limitada, com casos bem-sucedidos e outros mostrando resultados aquém do esperado. Recentemente, após a identificação da existência de células tronco no ligamento periodontal e a compreensão que a diferenciação destas células em outras mais diferenciadas (fibroblastos, osteoblastos e cementoblastos) é mediada por moléculas de sinalização (fatores de crescimento), alguns estudos foram publicados propondo a utilização clínica dos fatores de crescimento, isolados ou combinados, em diferentes tipos de veículos com o objetivo de favorecer a regeneração periodontal. Neste artigo, as características gerais e os estudos in vitro e in vivo evidenciando o papel dos principais fatores de crescimento utilizados na regeneração periodontal serão revistos com o objetivo de avaliar o papel dos fatores de crescimento na regeneração periodontal.

Polipeptidic growth factors are low density proteins secreted by different cells and tissues that regulate the basic events leading to periodontal regeneration: proliferation, chemotaxis, differentiation and protein synthesis. Although many methods for achieving regeneration of lost periodontal tissues have been suggested, there is poor predictability, with some well-succeeded cases and others showing unexpected results. Recently, after the identification of mesenchymal stem cells in the periodontal ligament and the understanding that the differentiation of these cells onto more differentiated ones (osteoblasts, cementoblasts, fibroblasts) is mediated by signaling molecules (growth factors), some studies have proposed the clinical use of growth factors isolated or in combination to enhance periodontal regeneration outcomes. In this paper, the characteristics and in vitro and the in vivo studies evaluating the role of growth factors in periodontal regeneration will be reviewed to evaluate the role of growth factors in periodontal regeneration.
Descritores: Quimiotaxia
Regeneração Tecidual Guiada Periodontal
Peptídeos e Proteínas de Sinalização Intercelular
Mitógenos
Periodontia
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR510.1 - Biblioteca Central


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Id: lil-751309
Autor: Pereira, Elisângela Vitoriano; Costa, Jorge de Assis; Alfenas, Rita de Cássia Gonçalves.
Título: Effect of glycemic index on obesity control
Fonte: Arch. endocrinol. metab. (Online);59(3):245-251, 06/2015. tab, graf.
Idioma: en.
Resumo: Objective Evaluate the effect of glycemic index (GI) on biochemical parameters, food intake, energy metabolism, anthropometric measures and body composition in overweight subjects.Materials and methods Simple blind study, in which nineteen subjects were randomly assigned to consume in the laboratory two daily low GI (n = 10) or high GI (n = 9) meals, for forty-five consecutive days. Habitual food intake was assessed at baseline. Food intake, anthropometric measures and body composition were assessed at each 15 days. Energy metabolism and biochemical parameters were evaluated at baseline and the end of the study.Results Low GI meals increased fat oxidation, and reduced waist circumference and HOMA-IR, while high GI meals increased daily dietary fiber and energy intake compared to baseline. There was a higher reduction on waist circumference and body fat, and a higher increase on postprandial fat oxidation in response to the LGI meals than after high GI meals. High GI meals increased fasting respiratory coefficient compared to baseline and low GI meals.Conclusion The results of the present study showed that the consumption of two daily low GI meals for forty-five consecutive days has a positive effect on obesity control, whereas, the consumption of high GI meals result has the opposite effect. Arch Endocrinol Metab. 2015;59(3):245-51.
Descritores: Proteínas de Bactérias/química
Escherichia coli/enzimologia
Proteínas de Membrana/química
Fenilalanina/química
-Motivos de Aminoácidos
Sequência de Aminoácidos
Proteínas de Bactérias/genética
Proteínas de Bactérias/metabolismo
Quimiotaxia
Sequência Conservada
Dimerização
Escherichia coli/química
Escherichia coli/genética
Escherichia coli/fisiologia
Dados de Sequência Molecular
Proteínas de Membrana/genética
Proteínas de Membrana/metabolismo
Conformação Proteica
Fenilalanina/genética
Fenilalanina/metabolismo
Tipo de Publ: Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Responsável: BR1.1 - BIREME


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Texto completo
Id: lil-735848
Autor: Zhong, Z.X.; Li, B.; Li, C.R.; Zhang, Q.F.; Liu, Z.D.; Zhang, P.F.; Gu, X.F.; Luo, H.; Li, M.J.; Luo, H.S.; Ye, G.H.; Wen, F.L..
Título: Role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;48(2):161-166, 02/2015. tab, graf.
Idioma: en.
Resumo: Our aim was to investigate the role of chemokines in promoting instability of coronary atherosclerotic plaques and the underlying molecular mechanism. Coronary angiography and intravascular ultrasound (IVUS) were performed in 60 stable angina pectoris (SAP) patients and 60 unstable angina pectoris (UAP) patients. The chemotactic activity of monocytes in the 2 groups of patients was examined in Transwell chambers. High-sensitivity C-reactive protein (hs-CRP), monocyte chemoattractant protein-1 (MCP-1), regulated on activation in normal T-cell expressed and secreted (RANTES), and fractalkine in serum were examined with ELISA kits, and expression of MCP-1, RANTES, and fractalkine mRNA was examined with real-time PCR. In the SAP group, 92 plaques were detected with IVUS. In the UAP group, 96 plaques were detected with IVUS. The plaques in the UAP group were mainly lipid 51.04% (49/96) and the plaques in the SAP group were mainly fibrous 52.17% (48/92). Compared with the SAP group, the plaque burden and vascular remodeling index in the UAP group were significantly greater than in the SAP group (P<0.01). Chemotactic activity and the number of mobile monocytes in the UAP group were significantly greater than in the SAP group (P<0.01). Concentrations of hs-CRP, MCP-1, RANTES, and fractalkine in the serum of the UAP group were significantly higher than in the serum of the SAP group (P<0.05 or P<0.01), and expression of MCP-1, RANTES, and fractalkine mRNA was significantly higher than in the SAP group (P<0.05). MCP-1, RANTES, and fractalkine probably promote instability of coronary atherosclerotic plaque.
Descritores: Angina Pectoris/metabolismo
Quimiocinas/metabolismo
Quimiotaxia/fisiologia
Doença da Artéria Coronariana/metabolismo
Monócitos/metabolismo
Placa Aterosclerótica/fisiopatologia
-Angina Pectoris/fisiopatologia
Proteína C-Reativa/análise
/sangue
CHEMOKINE CCLABDOMEN/sangue
/sangue
CHEMOKINE CCLTEMEFOS/sangue
/sangue
CHEMOKINE CXABATTOIRSCL1/sangue
Doença da Artéria Coronariana/fisiopatologia
Reação em Cadeia da Polimerase em Tempo Real
Ultrassonografia de Intervenção
Limites: Adulto
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-682593
Autor: Carlone, Robert; Dmetrichuk, Jennifer; Carter , Christopher; Spencer, Gaynor.
Título: Retinoids in development and regeneration in the CNS of vertebrates and invertebrates
Fonte: In: II International Congress on Neuroregeneration. Proceedings (selected papers). Rio de Janeiro, UFRJ, 2004. p.51-57, ilus.
Idioma: en.
Conferência: Apresentado em: International Congress on Neuroregeneration, 2, Rio de Janeiro, 2004.
Resumo: Retinoic acid (RA) is a biologically important metabolite of vitamin A that modulates growth and differentiation of many cell types. Although abundant in the CNS of many vertebrates, the precise role of RA in neural development has yet to be elucidated. Moreover, very little information is available regarding the role of RA in invertebrate neural development and regeneration. We have recently demonstrated that RA stimulates neurite outgrowth from adult newt spinal cord explants and may represent a significant factor in vivo in the reciprocal interactions between peripheral nerves and regenerating limb blastema cells. This interaction leads to the restoration of a functional limb after amputation. In support of this model, we have cloned a cDNA for the retinoic acid receptor of the β subtype (RARβ) whose expression is restricted to the spinal cord and brain of the adult newt and may be present in the limb blastema. This receptor may mediate the trophic effects of blastema-derived RA on neurite outgrowth and chemotaxis from spinal cord neurons. We have also extended our studies on the role of RA to the simple nervous system of the mollusc, Lymnaea stagnalis. Preliminary data support a role for RA in the survival, outgrowth, and chemotactic response of single, isolated, identifiable neurons in culture. This work represents the first evidence for chemotaxis and trophic effects of retinoids in an invertebrate nervous system. It is hoped that our work will shed light on the evolutionary conservation of a role for RA in neural development and regeneration.
Descritores: Sistema Nervoso Central
Quimiotaxia
Invertebrados
Moluscos
Neurônios
Salamandridae
Coluna Vertebral
Tretinoína
Vertebrados
Vitamina A
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM
BR408.1; 616.8, P963, 2004



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