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Assis, Simone Gonçalves de
Id: biblio-968755
Autor: Ferreira, Letícia Carvalho de M.
Título: Crianças e adolescentes desaparecidos: visões e divisões em torno de um drama de muitas faces / Missing children and adolescents: visions and divisions around a multi-faceted drama
Fonte: In: Assis, Simone Gonçalves de; Silveira, Liane Maria Braga. O tema da violência no ensino em saúde coletiva: Articulações com pesquisa e extensão. Rio de Janeiro, E-papers, 2018. p.314-314.
Idioma: pt.
Resumo: O presente capítulo chama atenção para a ausência e um fórum voltado especificamente para a discussão de casos de crianças e adolescentes desaparecidos , o que reflete menos uma suposta desimportância atribuída á temática e mais as dificuldades de se encontrar uma definição consensual das responsabilidades por sua gestão. Mostra também outra inovação promovida pelo ECA: a determinação de que uma das linhas da política de atendimento á criança e ao adolescente no Brasil deve ser provisão de serviços "de identificação e localização de pais, responsável, crianças e adolescentes desaparecidos. " (AU)
Descritores: Família
Defesa da Criança e do Adolescente
-Criança Abandonada
Crime
Reação de Fuga
Limites: Humanos
Tipo de Publ: Livro-Texto
Responsável: BR1782.1 - Núcleo de Informação e Documentação Cecília Minayo
BR1782.1; 362.1040981, T278


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Id: lil-716771
Autor: Billiet, Laura.
Título: Contribuição à psicanálise: irmãos e lutas fratricidas. psicossomática / Aporte al psicoanálisis: hermanos y lucha fratricida. psicosomática / Contributions to psychoanalysis: brothers and fratricidal struggle. psychosomatic
Fonte: Rev. psicanal;21(1):125-140, abr. 2014.
Idioma: pt.
Resumo: Neste artigo, veremos duas questões. Por um lado, a partir de Freud, sintetizo a perspectiva psicossomática, que considera que todos os seres humanos constituem uma unidade psicofísica e que todo o processo físico tem seu correlato afetivo específico. Como exemplo, destaco a importância do DNA mitocondrial, herdado somente da mãe. A outra questão que desenvolvo é seu correlato psíquico. Para isso, diferentemente de Freud, considero que a verdadeira horda primitiva é a família consanguínea (todos com todos, inclusive a própria mãe), e que – na filogenia – depois de se estabelecer a primeira proibição do incesto, começou a luta fratricida (todos contra todos). Estas marcas filogenéticas ganham força através da experiência ontogenética universal: estado pré-natal em e com a mãe, vinculo denominado siamês. O representante pós-natal dessa poderosa díade é a criança indômita. Nós a expressamos quando aspiramos restabelecer aquela segurança original, quando empreendemos lutas fratricidas para recuperar um lugar em e com equivalentes maternos (cônjuge, filhos, netos, líderes empresariais, institucionais, partidos políticos, etc.). Proponho adicionar às fases de desenvolvimento evolutivo o complexo prévio: estado siamês em e com a mãe-criança indômita-luta fratricida. E interpretar sua transferência em todas as biografias.

In this work I refer to two issues. First, from Freud, I synthesize a psychosomatic perspective, which considers that all human beings constitute a psychophysical unity and that every physical process has its specific affective correlate. As an example I focus on the importance of mitochondrial DNA, inherited only from the mother. The other issue is its psychical correlate. For this, unlike Freud, I rescue that the true primitive horde was the consanguineous family (everybody with everybody, even with their own mother). Thus – in the phylogeny – after establishing the first prohibition of incest, fratricide struggle began (all against all). These phylogenetic footprints gain strength by universal ontogenetic experience: prenatal state in and with mom, relationship that I call siamese. The postnatal representative of this powerful dyad is the indomitable child. We express it when we wish to restore that original security, when we establish fraternal struggles to regain a place in and with maternal equivalents (partners, children, grandchildren, business and institutional leaders, political parties, etc.). I propose to add in evolutionary developmental stages to this prior complex: siamese state in and with mom-indomitable child-fratricidal struggle. And interpret their transfer in all biographies.

En este trabajo me refiero a dos cuestiones. Por un lado, a partir de Freud sintetizo la perspectiva psicosomática que considera que todos los seres humanos constituimos una unidad psicofísica y que todo proceso físico posee su específico correlato afectivo. Como ejemplo me centro en la importancia del ADN mitocondrial, heredado solo por vía materna. Así, la otra cuestión que desarrollo es su correlato psíquico. Para eso, a diferencia de Freud, rescato que la verdadera horda primitiva fue la familia consanguínea (todos con todos, incluso la propia madre), y que – en la filogenia – luego de establecer la primera prohibición del incesto, comenzó la lucha fratricida (todos contra todos). Estas huellas filogenéticas cobran fuerza por la experiencia ontogenética universal: el estado prenatal en y con mamá, vínculo que denomino siamés. El representante postnatal de esta poderosa díada lo denomino niño indómito. Lo expresamos cuando aspiramos a restablecer aquella originaria seguridad, cuando establecemos luchas fraternas para reconquistar un lugar en y con equivalentes maternos (pareja, hijos, nietos, líderes empresariales, institucionales, partidos políticos, etc.). Propongo agregar en las fases del desarrollo evolutivo el complejo previo: estado siamés em y con mamá-niño indómito-lucha fratricida. E interpretar su transferencia en todas las biografias.
Descritores: Genes Mitocondriais/genética
Psicanálise
Medicina Psicossomática
Relações Familiares/etnologia
-Reação de Fuga
Psicanálise/métodos
Relações Materno-Fetais/psicologia
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: BR18.1 - Biblioteca FAMED/HCPA


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Texto completo SciELO Brasil
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Id: lil-650579
Autor: Camplesi Jr, M.; Bortoli, V.C.de; Soares, V. de Paula; Nogueira, R.L.; Zangrossi Jr., H..
Título: Dorsal periaqueductal gray stimulation facilitates anxiety-, but not panic-related, defensive responses in rats tested in the elevated T-maze
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(11):1025-1030, Nov. 2012. ilus, tab.
Idioma: en.
Resumo: The escape response to electrical or chemical stimulation of the dorsal periaqueductal gray matter (DPAG) has been associated with panic attacks. In order to explore the validity of the DPAG stimulation model for the study of panic disorder, we determined if the aversive consequences of the electrical or chemical stimulation of this midbrain area can be detected subsequently in the elevated T-maze. This animal model, derived from the elevated plus-maze, permits the measurement in the same rat of a generalized anxiety- and a panic-related defensive response, i.e., inhibitory avoidance and escape, respectively. Facilitation of inhibitory avoidance, suggesting an anxiogenic effect, was detected in male Wistar rats (200-220 g) tested in the elevated T-maze 30 min after DPAG electrical stimulation (current generated by a sine-wave stimulator, frequency at 60 Hz) or after local microinjection of the GABA A receptor antagonist bicuculline (5 pmol). Previous electrical (5, 15, 30 min, or 24 h before testing) or chemical stimulation of this midbrain area did not affect escape performance in the elevated T-maze or locomotion in an open-field. No change in the two behavioral tasks measured by the elevated T-maze was observed after repetitive (3 trials) electrical stimulation of the DPAG. The results indicate that activation of the DPAG caused a short-lived, but selective, increase in defensive behaviors associated with generalized anxiety.
Descritores: Ansiedade/fisiopatologia
Comportamento Animal/efeitos dos fármacos
Reação de Fuga/efeitos dos fármacos
Transtorno de Pânico/fisiopatologia
Substância Cinzenta Periaquedutal/efeitos dos fármacos
-Comportamento Animal/fisiologia
Bicuculina/farmacologia
Eletrodos Implantados
Reação de Fuga/fisiologia
Aprendizagem em Labirinto/efeitos dos fármacos
Aprendizagem em Labirinto/fisiologia
Substância Cinzenta Periaquedutal/fisiologia
Ratos Wistar
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Texto completo SciELO Costa Rica
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Id: lil-637994
Autor: Cooper, Jr, William E.
Título: Escape tactics and effects of perch height and habituation on flight initiation distance in two Jamaican anoles (Squamata: Polychrotidae)
Fonte: Rev. biol. trop;58(4):1199-1209, dic. 2010. graf.
Idioma: en.
Resumo: Escape by Anolis lizards is influenced by microhabitats and fight initiation distance increases with predation risk. Differences in microhabitat use among ecomorphs affect escape behavior, but only two studies have reported ecomorphological differences in flight initiation distance among Greater Antillean species. I studied effects of predation risk and microhabitats on escape behavior by conducting field experiments using two species of anoles, Anolis lineatopus and A. grahami, on the campus of the University of the West Indies at Mona, Jamaica. Because ecomorphological variation of anoles has evolved independently within each island of the Greater Antilles, but relationships between ecomorphs and escape behaviors are poorly known, I characterized microhabitat use and escape tactics, and determined relationships between flight initiation distance and two risk factors, habituation to human presence and perch height, in Anolis lineatopus, a trunk-ground anole and A. grahami, a trunk-crown anole. Sample sizes for A. lineatopus and A. grahami were 214 and 93, for microhabitat use and escape destinations, 74 and 34 for human presence and 125 and 34 for perch height. The two species occurred in similar microhabitats and exhibited similar escape tactics, but exhibited key differences expected for their ecomorphs. Both species were sighted frequently on the ground and on trees, but A. lineatopus were more frequently on ground and were perched lower than A. grahami. Both species escaped from ground to trees and when on trees hid on far sides and escaped without changing climbing direction with equal frequency. The frequency of fleeing upward was greater for A. grahami than A. lineatopus. Both species exhibited habituation by having shorter flight initiation distances in areas with more frequent exposure to people. In both species flight initiation distance increased as perch height decreased because, lizards had to climb farther to be out of reach when perched lower. The relationship between flight initiation distance and perch height may apply to other anole ecomorphs that flee upward when low perched on trees. Rev. Biol. Trop. 58 (4): 1199-1209. Epub 2010 December 01.

El escape de las largarijas Anolis está influenciado por el microhábitat y la distancia de iniciación de escape incrementa el riesgo de depredación. Las diferencias en el uso de microhábitats entre ecomorfos afecta el comportamiento de escape, pero sólo dos estudios han reportado diferencias ecomorfológicas en la distancia de iniciación de escape entre las especies de las Antillas Mayores. Se estudió el efecto de riesgo de depredación y la influencia del microhábitat en el comportamiento de escape, mediante la realización de experimentos de campo con Anolis lineatopus y A. grahami, en el campus de la Universidad West Indies en Mona, Jamaica. Debido a que las variaciones ecomorfológicas de Anolis han evolucionado independientemente en cada isla de las Antillas Mayores, la relación entre ecomorfos y el comportamiento de escape son pobremente conocidos. Se caracteriza el uso del microhábitat y las tácticas de escape, se determinan las relaciones entre la distancia de iniciación de escape y los dos factores de riesgo (habituación a presencia humana y altura a la que se posan) de Anolis lineatopus, una lagartija que habita en troncos-tierra y A. grahami, una lagartija de troncos-partes más altas. Los tamaños de muestra para A. lineatopus y A. grahami fueron: 214 y 93, para uso del microhábitat y destinos de escape 74, para presencia humana 34 y para perchas altas 125 y 34. Las dos especies se presentan en microhábitats similares y mostraron tácticas de escape parecidas, pero exhibieron diferencias claves esperadas para sus ecomorfos. Ambas especies fueron vistas con frecuencia en el suelo y en los árboles, pero A. lineatopus fue encontrada más frecuentemente en el suelo y debajo de A. grahami. Ambas especies escaparon del suelo a esconderse en los árboles y huían con igual frecuencia sin cambiar de dirección. La frecuencia de huir hacia arriba fue mayor para A grahami. Ambas especies mostraron habituación al tener distancias más cortas de iniciación de escape en zonas con exposición frecuente a la gente y la distancia de iniciación de escape incrementa cuando la altura de la percha disminuye, porque las lagartijas tienden a subir más al estar fuera de nuestro alcance cuando se posan en la parte baja. La relación entre la distancia de iniciación de escape y altura de la percha puede aplicar a otros ecomorfos de Anolis que huyen hacia arriba cuando están posados en las partes bajas de los árboles.
Descritores: Ecossistema
Reação de Fuga/fisiologia
Lagartos/fisiologia
-Jamaica
Comportamento Predatório
Especificidade da Espécie
Limites: Animais
Humanos
Responsável: CR1.1 - BINASSS - Biblioteca Nacional de Salud y Seguridad Social


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Texto completo SciELO Brasil
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Id: lil-622759
Autor: Herman, J.P.; McKlveen, J.M.; Solomon, M.B.; Carvalho-Netto, E.; Myers, B..
Título: Neural regulation of the stress response: glucocorticoid feedback mechanisms
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(4):292-298, Apr. 2012. ilus.
Idioma: en.
Resumo: The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and to restore homeostasis after the immediate challenge has subsided. Release of glucocorticoids is mediated by the hypothalamo-pituitary-adrenal (HPA) axis, driven by a neural signal originating in the paraventricular nucleus (PVN). Stress levels of glucocorticoids bind to glucocorticoid receptors in multiple body compartments, including the brain, and consequently have wide-reaching actions. For this reason, glucocorticoids serve a vital function in negative feedback inhibition of their own secretion. Negative feedback inhibition is mediated by a diverse collection of mechanisms, including fast, non-genomic feedback at the level of the PVN, stress-shut-off at the level of the limbic system, and attenuation of ascending excitatory input through destabilization of mRNAs encoding neuropeptide drivers of the HPA axis. In addition, there is evidence that glucocorticoids participate in stress activation via feed-forward mechanisms at the level of the amygdala. Feedback deficits are associated with numerous disease states, underscoring the necessity for adequate control of glucocorticoid homeostasis. Thus, rather than having a single, defined feedback ‘switch’, control of the stress response requires a wide-reaching feedback ‘network’ that coordinates HPA activity to suit the overall needs of multiple body systems.
Descritores: Retroalimentação Fisiológica/fisiologia
Glucocorticoides/fisiologia
Sistema Hipotálamo-Hipofisário/metabolismo
Núcleo Hipotalâmico Paraventricular/metabolismo
Sistema Hipófise-Suprarrenal/metabolismo
Estresse Fisiológico/fisiologia
-Reação de Fuga/fisiologia
Sistema Hipotálamo-Hipofisário/fisiologia
Núcleo Hipotalâmico Paraventricular/fisiologia
Sistema Hipófise-Suprarrenal/fisiologia
Limites: Animais
Humanos
Camundongos
Ratos
Tipo de Publ: Research Support, N.I.H., Extramural
Revisão
Responsável: BR1.1 - BIREME


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Id: lil-622757
Autor: Fogaça, M.V.; Lisboa, S.F.; Aguiar, D.C.; Moreira, F.A.; Gomes, F.V.; Casarotto, P.C.; Guimarães, F.S..
Título: Fine-tuning of defensive behaviors in the dorsal periaqueductal gray by atypical neurotransmitters
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(4):357-365, Apr. 2012. tab.
Idioma: en.
Resumo: This paper presents an up-to-date review of the evidence indicating that atypical neurotransmitters such as nitric oxide (NO) and endocannabinoids (eCBs) play an important role in the regulation of aversive responses in the periaqueductal gray (PAG). Among the results supporting this role, several studies have shown that inhibitors of neuronal NO synthase or cannabinoid receptor type 1 (CB1) receptor agonists cause clear anxiolytic responses when injected into this region. The nitrergic and eCB systems can regulate the activity of classical neurotransmitters such as glutamate and γ-aminobutyric acid (GABA) that control PAG activity. We propose that they exert a ‘fine-tuning’ regulatory control of defensive responses in this area. This control, however, is probably complex, which may explain the usually bell-shaped dose-response curves observed with drugs that act on NO- or CB1-mediated neurotransmission. Even if the mechanisms responsible for this complex interaction are still poorly understood, they are beginning to be recognized. For example, activation of transient receptor potential vanilloid type-1 channel (TRPV1) receptors by anandamide seems to counteract the anxiolytic effects induced by CB1 receptor activation caused by this compound. Further studies, however, are needed to identify other mechanisms responsible for this fine-tuning effect.
Descritores: Ansiedade/fisiopatologia
Reação de Fuga/fisiologia
Neurotransmissores/fisiologia
Substância Cinzenta Periaquedutal/fisiologia
Transmissão Sináptica/fisiologia
-Ansiedade/metabolismo
Ácidos Araquidônicos/farmacologia
Agonistas de Receptores de Canabinoides/farmacologia
Endocanabinoides/farmacologia
Endocanabinoides/fisiologia
Óxido Nítrico/fisiologia
Substância Cinzenta Periaquedutal/metabolismo
Alcamidas Poli-Insaturadas/farmacologia
Canais de Cátion TRPV/fisiologia
Limites: Animais
Camundongos
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Revisão
Responsável: BR1.1 - BIREME


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Texto completo SciELO Brasil
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Id: lil-622754
Autor: Biagioni, A.F.; Silva, J.A.; Coimbra, N.C..
Título: Panic-like defensive behavior but not fear-induced antinociception is differently organized by dorsomedial and posterior hypothalamic nuclei of Rattus norvegicus (Rodentia, Muridae)
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(4):328-336, Apr. 2012. ilus.
Idioma: en.
Resumo: The hypothalamus is a forebrain structure critically involved in the organization of defensive responses to aversive stimuli. Gamma-aminobutyric acid (GABA)ergic dysfunction in dorsomedial and posterior hypothalamic nuclei is implicated in the origin of panic-like defensive behavior, as well as in pain modulation. The present study was conducted to test the difference between these two hypothalamic nuclei regarding defensive and antinociceptive mechanisms. Thus, the GABA A antagonist bicuculline (40 ng/0.2 µL) or saline (0.9% NaCl) was microinjected into the dorsomedial or posterior hypothalamus in independent groups. Innate fear-induced responses characterized by defensive attention, defensive immobility and elaborate escape behavior were evoked by hypothalamic blockade of GABA A receptors. Fear-induced defensive behavior organized by the posterior hypothalamus was more intense than that organized by dorsomedial hypothalamic nuclei. Escape behavior elicited by GABA A receptor blockade in both the dorsomedial and posterior hypothalamus was followed by an increase in nociceptive threshold. Interestingly, there was no difference in the intensity or in the duration of fear-induced antinociception shown by each hypothalamic division presently investigated. The present study showed that GABAergic dysfunction in nuclei of both the dorsomedial and posterior hypothalamus elicit panic attack-like defensive responses followed by fear-induced antinociception, although the innate fear-induced behavior originates differently in the posterior hypothalamus in comparison to the activity of medial hypothalamic subdivisions.
Descritores: Núcleo Hipotalâmico Dorsomedial/fisiologia
Reação de Fuga/fisiologia
Hipotálamo Posterior/fisiologia
Transtorno de Pânico/metabolismo
-Bicuculina/farmacologia
Núcleo Hipotalâmico Dorsomedial/efeitos dos fármacos
Antagonistas de Receptores de GABA-A/farmacologia
Hipotálamo Posterior/efeitos dos fármacos
Aprendizagem em Labirinto
Limiar da Dor/efeitos dos fármacos
Transtorno de Pânico/etiologia
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-622750
Autor: Brenes, J.C.; Broiz, A.C.; Bassi, G.S.; Schwarting, R.K.W.; Brandão, M.L..
Título: Involvement of midbrain tectum neurokinin-mediated mechanisms in fear and anxiety
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;45(4):349-356, Apr. 2012. ilus.
Idioma: en.
Resumo: Electrical stimulation of midbrain tectum structures, particularly the dorsal periaqueductal gray (dPAG) and inferior colliculus (IC), produces defensive responses, such as freezing and escape behavior. Freezing also ensues after termination of dPAG stimulation (post-stimulation freezing). These defensive reaction responses are critically mediated by γ-aminobutyric acid and 5-hydroxytryptamine mechanisms in the midbrain tectum. Neurokinins (NKs) also play a role in the mediation of dPAG stimulation-evoked fear, but how NK receptors are involved in the global processing and expression of fear at the level of the midbrain tectum is yet unclear. The present study investigated the role of NK-1 receptors in unconditioned defensive behavior induced by electrical stimulation of the dPAG and IC of male Wistar rats. Spantide (100 pmol/0.2 μL), a selective NK-1 antagonist, injected into these midbrain structures had anti-aversive effects on defensive responses and distress ultrasonic vocalizations induced by stimulation of the dPAG but not of the IC. Moreover, intra-dPAG injections of spantide did not influence post-stimulation freezing or alter exploratory behavior in rats subjected to the elevated plus maze. These results suggest that NK-1 receptors are mainly involved in the mediation of defensive behavior organized in the dPAG. Dorsal periaqueductal gray-evoked post-stimulation freezing was not affected by intra-dPAG injections of spantide, suggesting that NK-1-mediated mechanisms are only involved in the output mechanisms of defensive behavior and not involved in the processing of ascending aversive information from the dPAG.
Descritores: Ansiedade/fisiopatologia
Reação de Fuga/fisiologia
Medo/fisiologia
Colículos Inferiores/efeitos dos fármacos
Neurocinina A/farmacologia
Substância Cinzenta Periaquedutal/efeitos dos fármacos
Receptores da Neurocinina-1/antagonistas & inibidores
Substância P/análogos & derivados
-Aprendizagem da Esquiva
Estimulação Elétrica
Colículos Inferiores/fisiologia
Substância Cinzenta Periaquedutal/fisiologia
Ratos Wistar
Substância P/farmacologia
Vocalização Animal
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-600686
Autor: Diniz, L; dos Reis, B. B; de Castro, G. M; Medalha, C. C; Viana, M. B.
Título: Effects of chronic corticosterone and imipramine administration on panic and anxiety-related responses
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;44(10):1048-1053, Oct. 2011. ilus.
Idioma: en.
Resumo: It is known that chronic high levels of corticosterone (CORT) enhance aversive responses such as avoidance and contextual freezing. In contrast, chronic CORT does not alter defensive behavior induced by the exposure to a predator odor. Since different defense-related responses have been associated with specific anxiety disorders found in clinical settings, the observation that chronic CORT alters some defensive behaviors but not others might be relevant to the understanding of the neurobiology of anxiety. In the present study, we investigated the effects of chronic CORT administration (through surgical implantation of a 21-day release 200 mg pellet) on avoidance acquisition and escape expression by male Wistar rats (200 g in weight at the beginning of the experiments, N = 6-10/group) tested in the elevated T-maze (ETM). These defensive behaviors have been associated with generalized anxiety and panic disorder, respectively. Since the tricyclic antidepressant imipramine is successfully used to treat both conditions, the effects of combined treatment with chronic imipramine (15 mg, ip) and CORT were also investigated. Results showed that chronic CORT facilitated avoidance performance, an anxiogenic-like effect (P < 0.05), without changing escape responses. Imipramine significantly reversed the anxiogenic effect of CORT (P < 0.05), although the drug did not exhibit anxiolytic effects by itself. Confirming previous observations, imipramine inhibited escape responses, a panicolytic-like effect. Unlike chronic CORT, imipramine also decreased locomotor activity in an open field. These data suggest that chronic CORT specifically altered ETM avoidance, a fact that should be relevant to a better understanding of the physiopathology of generalized anxiety and panic disorder.
Descritores: Antidepressivos Tricíclicos/administração & dosagem
Ansiedade/tratamento farmacológico
Comportamento Animal/efeitos dos fármacos
Corticosterona/administração & dosagem
Imipramina/administração & dosagem
Transtorno de Pânico/tratamento farmacológico
-Antidepressivos Tricíclicos/farmacologia
Corticosterona/farmacologia
Reação de Fuga/efeitos dos fármacos
Imipramina/farmacologia
Aprendizagem em Labirinto/efeitos dos fármacos
Atividade Motora/efeitos dos fármacos
Ratos Wistar
Limites: Animais
Masculino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-557008
Autor: Hosseini, Mahmoud; Headari, Raheleh; Oryan, Sharbanoo; Hadjzadeh, Mosa Alreza; Saffarzadeh, Fatima; Khazaei, Majid.
Título: The effect of chronic administration of L-arginine on the learning and memory of estradiol-treated ovariectomized rats tested in the morris water maze
Fonte: Clinics;65(8):803-807, June 2010. graf.
Idioma: en.
Resumo: OBJECTIVE: The present study was carried out to evaluate the effect of L-arginine on the learning and memory of estradiol-treated ovariectomized (OVX) rats. METHODS: Forty-eight rats were divided into six groups: (1) sham, (2) OVX, (3) sham-Est, (4) OVX-Est, (5) sham-Est-LA, and (6) OVX-Est-LA. The animals of the sham-Est and OVX-Est groups were treated by weekly injection of estradiol valerate (2mg/kg). The sham-Est-LA and OVX-Est-LA groups were treated in the same manner but with an additional daily injection of L-arginine (200mg/kg). After eight weeks, animals of all groups were tested in the Morris water maze. The escape latency and path traveled to reach the platform were compared between groups. RESULTS: Time latency and path length in the OVX group were significantly higher than in the sham group (P<0.05). The OVX-Est group had a significantly shorter traveled path length and time latency compared to the OVX group (P<0.001). Time latency and path length in the sham-Est group was significantly higher than in the sham group (P<0.001). Time latency and path length in the OVX-Est-LA group were significantly higher than in the OVX-Est group. CONCLUSIONS: These results allow us to propose that chronic treatment with estradiol enhances the spatial learning and memory of OVX rats, and that long term L-arginine treatment attenuates the effects of improvement produced by estradiol in OVX rats.
Descritores: Arginina/administração & dosagem
Comportamento Animal/efeitos dos fármacos
Estradiol/administração & dosagem
Estrogênios/administração & dosagem
Aprendizagem em Labirinto/efeitos dos fármacos
Memória/efeitos dos fármacos
-Reação de Fuga
Ovariectomia
Ratos Wistar
Tempo de Reação
Limites: Animais
Feminino
Ratos
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME



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