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Id: lil-798081
Autor: Vasconcelos-Moreno, Mirela P; Bücker, Joana; Bürke, Kelen P; Czepielewski, Leticia; Santos, Barbara T; Fijtman, Adam; Passos, Ives C; Kunz, Mauricio; Bonnín, Caterina del Mar; Vieta, Eduard; Kapczinski, Flavio; Rosa, Adriane R; Kauer-Sant’Anna, Marcia.
Título: Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls
Fonte: Rev. bras. psiquiatr;38(4):275-280, Oct.-Dec. 2016. tab.
Idioma: en.
Resumo: Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations.
Descritores: Transtorno Bipolar/psicologia
Cognição/fisiologia
Transtornos Cognitivos/psicologia
Irmãos/psicologia
-Aprendizagem Verbal
Estudos de Casos e Controles
Estudos Transversais
Análise Multivariada
Transtornos Cognitivos/fisiopatologia
Endofenótipos
Deficiências da Aprendizagem/diagnóstico
Transtornos da Memória/diagnóstico
Limites: Humanos
Masculino
Feminino
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: lil-798080
Autor: Brietzke, Elisa; Rosa, Adriane R; Pedrini, Mariana; Noto, Mariane N; Kapczinski, Flavio; Scott, Jan.
Título: Challenges and developments in research of the early stages of bipolar disorder
Fonte: Rev. bras. psiquiatr;38(4):329-337, Oct.-Dec. 2016.
Idioma: en.
Resumo: Recently, attention in the field of bipolar disorder (BD) has focused on prevention, including early detection and intervention, as these strategies have the potential to delay, lessen the severity, or even prevent full-blown episodes of BD. Although knowledge of the neurobiology of BD has advanced substantially in the last two decades, most research was conducted with chronic patients. The objective of this paper is to comprehensively review the literature regarding the early stages of BD, to explore recent discoveries on the neurobiology of these stages, and to discuss implications for research and clinical care. The following databases were searched: PubMed, PsycINFO, Cochrane Library, and SciELO. Articles published in English from inception to December 2015 were retrieved. Several research approaches were used, including examination of offspring studies, retrospective studies, prospective studies of clinical high-risk populations, and exploration of the progression after the first manic episode. Investigations with neuroimaging, cognition assessments, and biomarkers provide promising (although not definitive) evidence of alterations in the neural substrate during the at-risk stage. Research on BD should be expanded to encompass at-risk states and aligned with recent methodological progress in neuroscience.
Descritores: Transtorno Bipolar/diagnóstico
Pesquisa Biomédica
-Transtorno Bipolar/diagnóstico por imagem
Biomarcadores
Estudos Prospectivos
Estudos Retrospectivos
Transtornos Cognitivos/diagnóstico
Progressão da Doença
Diagnóstico Precoce
Limites: Humanos
Tipo de Publ: Revisão
Responsável: BR1.1 - BIREME


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Id: lil-547319
Autor: Solowij, Nadia; Pesa, Nicole.
Título: Anormalidades cognitivas no uso da cannabis / Cognitive abnormalities and cannabis use
Fonte: Rev. bras. psiquiatr;32(supl.1):531-540, maio 2010.
Idioma: pt.
Projeto: National Health de neuroimagem multimodal; . Medical Research Council of Australia.
Resumo: OBJETIVO: Evidências de que o uso de cannabis prejudica funções cognitivas em humanos têm-se acumulado nas décadas recentes. O propósito desta revisão é o de atualizar o conhecimento nesta área com novos achados a partir da literatura mais recente. MÉTODO: As buscas na literatura foram realizadas utilizando-se o banco de dados Web of Science até fevereiro de 2010. Foram buscados os termos "cannabi*" ou "marijuana" e "cogniti*" ou "memory" ou "attention" ou "executive function", e os estudos em humanos foram revisados preferencialmente em relação aos estudos em animais. DISCUSSÃO: O uso de cannabis prejudica a memória, a atenção, o controle inibitório, as funções executivas e a tomada de decisões, tanto durante como após o período de intoxicação aguda, persistindo por horas, dias, semanas ou mais após o último uso. Os estudos de desafio farmacológico em humanos estão elucidando a natureza e os substratos neurais das alterações cognitivas associadas a vários canabinoides. O uso pesado ou de longo prazo de cannabis parece resultar em anormalidades cognitivas mais duradouras e possivelmente em alterações cerebrais estruturais. Efeitos cognitivos adversos maiores estão associados ao uso de cannabis quando este começa no início da adolescência. CONCLUSÃO: O sistema canabinoide endógeno está envolvido nos mecanismos de regulação neural que modulam os processos subjacentes a uma gama de funções cognitivas que estão prejudicadas pela cannabis. Os déficits em usuários humanos muito provavelmente refletem, portanto, neuroadaptações e o funcionamento alterado do sistema canabinoide endógeno.

OBJECTIVE: Evidence that cannabis use impairs cognitive function in humans has been accumulating in recent decades. The purpose of this overview is to update knowledge in this area with new findings from the most recent literature. METHOD: Literature searches were conducted using the Web of Science database up to February 2010. The terms searched were: "cannabi*" or "marijuana", and "cogniti*" or "memory" or "attention" or "executive function", and human studies were reviewed preferentially over the animal literature. DISCUSSION: Cannabis use impairs memory, attention, inhibitory control, executive functions and decision making, both during the period of acute intoxication and beyond, persisting for hours, days, weeks or more after the last use of cannabis. Pharmacological challenge studies in humans are elucidating the nature and neural substrates of cognitive changes associated with various cannabinoids. Long-term or heavy cannabis use appears to result in longer-lasting cognitive abnormalities and possibly structural brain alterations. Greater adverse cognitive effects are associated with cannabis use commencing in early adolescence. CONCLUSION: The endogenous cannabinoid system is involved in regulatory neural mechanisms that modulate processes underlying a range of cognitive functions that are impaired by cannabis. Deficits in human users most likely therefore reflect neuroadaptations and altered functioning of the endogenous cannabinoid system.
Descritores: Cannabis/efeitos adversos
Abuso de Maconha/complicações
-Fatores de Tempo
Transtornos Cognitivos/induzido quimicamente
Limites: Humanos
Animais
Tipo de Publ: Research Support, Non-U.S. Gov't
Revisão
Responsável: BR1.1 - BIREME


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Id: lil-792757
Autor: Ruas, Luiz Gustavo; Diniz, Breno S; Firmo, Josélia O; Peixoto, Sérgio V; Mambrini, Juliana V; Loyola-Filho, Antônio Ignácio de; Lima-Costa, Maria Fernanda; Castro-Costa, Érico.
Título: Components of the metabolic syndrome and depressive symptoms in community-dwelling older people: the Bambuí Cohort Aging Study
Fonte: Rev. bras. psiquiatr;38(3):183-189, July-Sept. 2016. tab.
Idioma: en.
Projeto: CNPq; . FINEP.
Resumo: Objective: To investigate the moderating effect of an increasing number of clustered metabolic syndrome (MetS) components on the association between MetS and depressive symptoms in a population-based cohort of older adults in Brazil. Methods: This analysis used data from the Bambuí Cohort Aging Study. Participants in this cross-sectional study comprised 1,469 community-dwelling older people aged ≥ 60 years. Analyses were performed to assess both the association between depressive symptoms and each individual MetS component and the association between depressive symptoms and clustering of an increasing number of MetS components. Results: High triglyceride level was the individual component that showed the strongest association with depressive symptoms (odds ratio [OR]: 1.47; 95% confidence intervals [95%CI] 1.19-1.81; p < 0.0001). Only the presence of three MetS components was associated with depressive symptoms (OR = 1.53; 95%CI 1.05-2.23; p = 0.025). No graded association was detected between increasing number of clustered MetS components and depressive symptoms. Conclusions: Increasing the number of MetS components did not impact the association with depressive symptoms. The association between high triglyceride level and depressive symptoms highlights the relevance of lipid metabolism abnormalities for the emergence of depressive symptoms in older adults.
Descritores: Síndrome Metabólica/fisiopatologia
Depressão/fisiopatologia
-Escalas de Graduação Psiquiátrica
Psicotrópicos/uso terapêutico
Brasil
Análise por Conglomerados
Estudos Transversais
Estudos Prospectivos
Fatores de Risco
Análise de Variância
Transtornos Cognitivos/fisiopatologia
Síndrome Metabólica/complicações
Depressão/complicações
Circunferência da Cintura
Estilo de Vida
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Feminino
Idoso
Responsável: BR1.1 - BIREME


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Id: biblio-844169
Autor: Ruiz-Veguilla, Miguel; Moreno-Granados, Josefa; Salcedo-Marin, Maria D; Barrigon, Maria L; Blanco-Morales, Maria J; Igunza, Evelio; Cañabate, Anselmo; Garcia, Maria D; Guijarro, Teresa; Diaz-Atienza, Francisco; Ferrin, Maite.
Título: Sex-specific cognitive abnormalities in early-onset psychosis
Fonte: Rev. bras. psiquiatr;39(1):28-35, Jan.-Mar. 2017. tab, graf.
Idioma: en.
Projeto: BAE.
Resumo: Objectives: Brain maturation differs depending on the area of the brain and sex. Girls show an earlier peak in maturation of the prefrontal cortex. Although differences between adult females and males with schizophrenia have been widely studied, there has been less research in girls and boys with psychosis. The purpose of this study was to examine differences in verbal and visual memory, verbal working memory, auditory attention, processing speed, and cognitive flexibility between boys and girls. Methods: We compared a group of 80 boys and girls with first-episode psychosis to a group of controls. Results: We found interactions between group and sex in verbal working memory (p = 0.04) and auditory attention (p = 0.01). The female controls showed better working memory (p = 0.01) and auditory attention (p = 0.001) than males. However, we did not find any sex differences in working memory (p = 0.91) or auditory attention (p = 0.93) in the psychosis group. Conclusions: These results are consistent with the presence of sex-modulated cognitive profiles at first presentation of early-onset psychosis.
Descritores: Esquizofrenia/fisiopatologia
Fatores Sexuais
Transtornos Cognitivos/fisiopatologia
-Psicologia do Esquizofrênico
Estudos de Casos e Controles
Córtex Pré-Frontal
Transtornos Cognitivos/psicologia
Memória de Curto Prazo
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Id: biblio-1090548
Autor: Coelho, Almir Resende; Perobelli, Júlia Licursi Lambertti; Sonobe, Lilian Shizuka; Moraes, Renato; Barros, Camila Giacomo de Carneiro; Abreu, Daniela Cristina Carvalho de.
Título: Severe Dizziness Related to Postural Instability, Changes in Gait and Cognitive Skills in Patients with Chronic Peripheral Vestibulopathy
Fonte: Int. arch. otorhinolaryngol. (Impr.);24(1):99-106, Jan.-Mar. 2020. tab.
Idioma: en.
Resumo: Abstract Introduction Peripheral vestibular disorders can lead to cognitive deficits and are more common in elderly patients. Objective To evaluate and correlate cognitive, balance and gait aspects in elderly women with chronic peripheral vestibular dizziness, and to compare them with elderly women without vestibular disorders. Methods Twenty-two women presenting peripheral vestibular dizziness episodes for at least six months participated in the study. The individuals were categorized by dizziness severity level: moderate (n = 11) or severe (n = 11). The control group (n = 11) included women showing no vestibulopathy, light-headedness or dizziness. Cognitive assessments and semi-static and dynamic balance assessments were performed with the Balance Master (Neurocom International, Inc., Clackamas, OR), while the Dizziness Handicap Inventory provided a score for the severity of the symptoms. The groups were submitted to statistics of inference and correlation between cognitive, balance and stability variables. Results The group with severe dizziness showed higher sway speed of the center of pressure in the anteroposterior direction, smaller step length, and slower gait than the control group. Regarding the cognitive variables, the group with severe dizziness symptoms presented significant correlations with stability and gait variables. Conclusion The relationship between cognitive aspects, balance and gait was stronger in women with severe dizziness than in those with no vestibulopathy.
Descritores: Doenças Vestibulares/complicações
Transtornos das Sensações/etiologia
Tontura/complicações
Equilíbrio Postural/fisiologia
-Índice de Gravidade de Doença
Doenças Vestibulares/fisiopatologia
Doenças Vestibulares/reabilitação
Transtornos Cognitivos/etiologia
Tontura/fisiopatologia
Marcha/fisiologia
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Idoso
Responsável: BR66.1 - Divisão de Biblioteca e Documentação


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Id: biblio-1039088
Autor: de Paula, Jonas J; Costa, Danielle S; Miranda, Débora M. de; Romano-Silva, Marco A.
Título: Brazilian version of the Cognitive Failures Questionnaire (CFQ): cross-cultural adaptation and evidence of validity and reliability
Fonte: Braz. J. Psychiatry (São Paulo, 1999, Impr.);40(3):312-315, July-Sept. 2018. tab.
Idioma: en.
Projeto: FAPEMIG; . CNPq; . FAPEMIG.
Resumo: Objective: Cognitive failures are simple mistakes in routine activities, such as forgetting commitments and experiencing difficulty concentrating. The Cognitive Failures Questionnaire (CFQ) was designed to assess the frequency of these errors in everyday life. Although widely used in psychiatry and psychology, both in clinical and research settings, it has not been adapted for use in Brazil. Our objective was to perform cross-cultural adaptation of the CFQ for the Brazilian reality and assess its validity and reliability. Methods: The original version of the CFQ was translated into Brazilian Portuguese by two independent researchers, analyzed by a multidisciplinary board of experts, and back-translated into English. The final version was administered to 225 adults. Validity was assessed by correlation with the Self Reporting Questionnaire-20 (SRQ-20) and the Adult Attention Deficit/Hyperactivity Disorder Self-Report Scale (ASRS-18). Reliability was analyzed by calculating internal consistency and test-retest stability. Results: The adapted version of the CFQ showed significant correlations with SRQ-20 (r = -0.311), ASRS-18 inattention (r = 0.696), and hyperactivity/impulsivity (r = 0.405) scores. Reliability analysis suggests high internal consistency (0.906) and temporal stability (0.813). Conclusion: The Brazilian Portuguese version of the CFQ showed moderate correlations with other measures of mental health, as well as adequate reliability.
Descritores: Comparação Transcultural
Inquéritos e Questionários/normas
Cognição/fisiologia
Transtornos Cognitivos/diagnóstico
-Escalas de Graduação Psiquiátrica
Psicometria
Transtorno do Deficit de Atenção com Hiperatividade/psicologia
Brasil
Inquéritos e Questionários
Reprodutibilidade dos Testes
Autorrelato
Idioma
Limites: Humanos
Masculino
Feminino
Adulto
Adulto Jovem
Tipo de Publ: Estudo de Validação
Responsável: BR1.1 - BIREME


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Id: biblio-1011508
Autor: Rabelo-da-Ponte, Francisco Diego; Pessoa Gomes, Jessica Maria; Torres, Nathércia Lima; Barbosa, João Ilo Coelho; de Andrade, Geanne Matos; Macedo, Danielle; Ceppi, Bruno.
Título: Behavioral, affective, and cognitive alterations induced by individual and combined environmental stressors in rats
Fonte: Braz. J. Psychiatry (São Paulo, 1999, Impr.);41(4):289-296, July-Aug. 2019. tab, graf.
Idioma: en.
Resumo: Objective: To evaluate whether exposing rats to individual or combined environmental stressors triggers endophenotypes related to mood and anxiety disorders, and whether this effect depends on the nature of the behavior (i.e., innate or learned). Methods: We conducted a three-phase experimental protocol. In phase I (baseline), animals subjected to mixed schedule of reinforcement were trained to press a lever with a fixed interval of 1 minute and a limited hold of 3 seconds. On the last day of phase I, an open-field test was performed and the animals were divided into four experimental groups (n=8/group). In phase II (repeated stress), each group was exposed to either hot air blast (HAB), paradoxical sleep deprivation (PSD) or both (HAB+PSD group) on alternate days over a 10-day period. Control group animals were not exposed to stressors. In phase III (post-stress evaluation), behavior was analyzed on the first (short-term effects), third (mid-term effects), and fifth (long-term effects) days after repeated stress. Results: The PSD group presented operant hyperactivity, the HAB group presented spontaneous hypoactivity and anxiety, and the HAB+PSD group presented spontaneous hyperactivity, operant hypoactivity, impulsivity, loss of interest, and cognitive impairment. Conclusion: A combination of environmental stressors (HAB and PSD) may induce endophenotypes related to bipolar disorder.
Descritores: Estresse Psicológico/fisiopatologia
Comportamento Animal
Transtorno Bipolar/fisiopatologia
Transtornos Cognitivos/fisiopatologia
-Ansiedade
Privação do Sono
Ratos Wistar
Cognição
Modelos Animais de Doenças
Limites: Animais
Masculino
Ratos
Responsável: BR1.1 - BIREME


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Lafer, Beny
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Id: biblio-959236
Autor: Fernandes, Francy B F; Rocca, Cristiana C; Gigante, Alexandre D; Dottori-Silva, Paola R; Gerchmann, Luciana; Rossini, Danielle; Sato, Rodrigo; Lafer, Beny; Nery, Fabiano G.
Título: The association between social skills deficits and family history of mood disorder in bipolar I disorder
Fonte: Rev. bras. psiquiatr;40(3):244-248, July-Sept. 2018. tab.
Idioma: en.
Resumo: Objective: To compare social skills and related executive functions among bipolar disorder (BD) patients with a family history of mood disorders (FHMD), BD patients with no FHMD and healthy control (HCs). Methods: We evaluated 20 euthymic patients with FHMD, 17 euthymic patients without FHMD, and 31 HCs using the Social Skills Inventory (SSI) and a neuropsychological battery evaluating executive function, inhibitory control, verbal fluency and estimated intelligence. Results: Both BD groups had lower SSI scores than controls. Scores for one subfactor of the social skills questionnaire, conversational skills and social performance, were significantly lower among patients with FHMD than among patients without FHMD (p = 0.019). Both groups of BD patients exhibited significant deficits in initiation/inhibition, but only BD patients with FHMD had deficits in verbal fluency, both compared to HC. There were no associations between social skills questionnaire scores and measures of cognitive function. Conclusion: Euthymic BD patients have lower social skills and executive function performance than HC. The presence of FHMD among BD patients is specifically associated with deficits in conversational and social performance skills, in addition to deficits in verbal fluency. Both characteristics might be associated with a common genetically determined pathophysiological substrate.
Descritores: Transtorno Bipolar/psicologia
Cognição
Transtornos Cognitivos/psicologia
Transtornos do Humor/psicologia
Função Executiva
Habilidades Sociais
-Comportamento Verbal/fisiologia
Transtorno Bipolar/genética
Indução de Remissão
Estudos de Casos e Controles
Transtornos Cognitivos/genética
Inteligência
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-837327
Autor: Avellar, Ariane Bernardes Camilo Castilho de; Junior, Gerival Vieira; Albuquerque, Lucas Alverne Freitas de; Macedo, Rodrigo Alvares Paiva; Dellaretti, Marcos.
Título: Prevalence of Cognitive Impairments in Patients with Good Functional Outcome in Late Phase Subarachnoid Hemorrhage / Prevalência de alterações cognitivas em pacientes com bom desfecho funcional na fase tardia da hemorragia subaracnóidea
Fonte: Arq. bras. neurocir;35(2):105-110, jun.2016.
Idioma: en.
Resumo: Prior studies have shown high prevalence of neuropsychological deficits after aneurysmal subarachnoid hemorrhage; however, few studies detect cognitive impairments in patients with good functional outcome, measured whith Rankin Modified Scale, in the late phase of subarachnoid hemorrhage. We confirmed a high prevalence of alterations in neuropsychological tests in 44 patients with Rankin Modified 2.We proposed the application of simple and fast tests that allowed us to detect impairments with precision similar to that of complex cognitive batteries used in previous studies. We also attempt to confirm statistical association between factors that could be related to poor cognitive outcome, like Hunt-Hess scale classification, bleeding intensity measured with Fisher scale, therapeutic type (microsurgery ou embolization), and aneurysm localization; however, there was no significance.

Estudos anteriores mostraram que a prevalência de déficits neuropsicológicos após hemorragia subaracnóide aneurismática é alto,mas poucos estudos detectaram alterações cognitiva sem pacientes com bom desfecho funcional,medido através da escada de Rankin Modificada, na fase tardia da hemorragia subaracnóide. O estudo confirmou em 44 pacientes com RankiN Modificado 2 a alta prevalência de alterações em testes neuropsicológicos. Propusemos a aplicação de testes simples e rápidos, capazes de detectar alterações, com precisão semelhante a baterias cognitivas complexas utilizadas em estudos anteriores.Nós também avaliamos a associação estatística entre alguns fatores como a escala de Hunt-Hess (HH), a intensidade do sangramento pela escala de Fisher, tipo de tratamento (microcirurgia ou embolização) e localização do aneurisma, ao pior desempenho cognitivo, no entanto não houve significância.
Descritores: Hemorragia Subaracnóidea
Hemorragia Subaracnóidea/complicações
Transtornos Cognitivos
Limites: Humanos
Masculino
Feminino
Responsável: BR584.1 - Biblioteca Central BSCAN



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