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Vieira, Silvia Regina Rios
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Id: biblio-977985
Autor: Robinson, Caroline Cabral; Rosa, Regis Goulart; Kochhann, Renata; Schneider, Daniel; Sganzerla, Daniel; Dietrich, Camila; Sanchez, Évelin Carneiro; Dutra, Francine Hoffmann; Oliveira, Maicon Quadro de; Anzolin, Luisa Barbosa; Menezes, Suelen Fardim de; Jeffman, Rodrigo; Souza, Denise de; Silva, Sâmia Faria da; Cruz, Luciane Nascimento; Boldo, Rodrigo; Cardoso, Juliana Rezende; Birriel, Daniella Cunha; Gamboa, Mariana Nunes; Machado, André Sant'Ana; Andrade, Juliana Mara Stormosvski de; Alencar, Cesar; Teixeira, Michelle Carneiro; Vieira, Silvia Regina Rios; Moreira, Fernanda Caleffe; Amaral, Alexandre; Silveira, Ana Paula Menezes; Teles, José Mario Meira; Oliveira, Daniela Cunha de; Oliveira Júnior, Lúcio Couto de; Castro, Lívia Correa e; Silva, Marli Sarmento da; Neves, Rafael Trevizoli; Gomes, Renata de Andrade; Ribeiro, Cinthia Mucci; Cavalcanti, Alexandre Biasi; Oliveira, Roselaine Pinheiro de; Maccari, Juçara Gasparetto; Berto, Paula Pinheiro; Martins, Lucieda Araújo; Santos, Rui Leandro da Silva; Ue, Luciana Yumi; Hammes, Luciano Serpa; Sharshar, Tarek; Bozza, Fernando; Falavigna, Maicon; Teixeira, Cassiano.
Título: Qualidade de vida pós-unidades de terapia intensiva: protocolo de estudo de coorte multicêntrico para avaliação de desfechos em longo prazo em sobreviventes de internação em unidades de terapia intensiva brasileiras / Quality of life after intensive care unit: a multicenter cohort study protocol for assessment of long-term outcomes among intensive care survivors in Brazil
Fonte: Rev. bras. ter. intensiva;30(4):405-413, out.-dez. 2018. tab, graf.
Idioma: pt.
Resumo: RESUMO Objetivo: Avaliar a prevalência de incapacidades físicas, cognitivas e psiquiátricas, fatores associados e sua relação com qualidade de vida em pacientes sobreviventes de internação em unidades de terapia intensiva brasileiras. Métodos: Um estudo de coorte prospectivo multicêntrico está sendo conduzido em dez unidades de terapia intensiva adulto clínico-cirúrgicas representativas das cinco regiões geopolíticas do Brasil. Pacientes com idade ≥ 18 anos que receberam alta das unidades de terapia intensiva participantes e permaneceram internados na unidade de terapia intensiva por 72 horas ou mais, nos casos de internação clínica ou cirúrgica de urgência, e por 120 horas ou mais, nos casos de internação cirúrgica eletiva, serão incluídos de forma consecutiva. Estes pacientes serão seguidos por 1 ano, por meio de entrevistas telefônicas estruturadas 3, 6 e 12 meses pós-alta da unidade de terapia intensiva. Dependência funcional, disfunção cognitiva, sintomas de ansiedade e depressão, sintomas de estresse pós-traumático, qualidade de vida relacionada à saúde, re-hospitalizações e mortalidade em longo prazo serão avaliados como desfechos. Discussão: O presente estudo tem o potencial de contribuir para o conhecimento a respeito da prevalência e dos fatores associados à síndrome pós-cuidados intensivos na população de pacientes adultos sobreviventes de internação em unidades de terapia intensiva brasileiras. Ademais, a associação entre síndrome pós-cuidados intensivos e qualidade de vida relacionada à saúde poderá ser estabelecida.

ABSTRACT Objective: To establish the prevalence of physical, cognitive and psychiatric disabilities, associated factors and their relationship with the qualities of life of intensive care survivors in Brazil. Methods: A prospective multicenter cohort study is currently being conducted at 10 adult medical-surgical intensive care units representative of the 5 Brazilian geopolitical regions. Patients aged ≥ 18 years who are discharged from the participating intensive care units and stay 72 hours or more in the intensive care unit for medical or emergency surgery admissions or 120 hours or more for elective surgery admissions are consecutively included. Patients are followed up for a period of one year by means of structured telephone interviews conducted at 3, 6 and 12 months after discharge from the intensive care unit. The outcomes are functional dependence, cognitive dysfunction, anxiety and depression symptoms, posttraumatic stress symptoms, health-related quality of life, rehospitalization and long-term mortality. Discussion: The present study has the potential to contribute to current knowledge of the prevalence and factors associated with postintensive care syndrome among adult intensive care survivors in Brazil. In addition, an association might be established between postintensive care syndrome and health-related quality of life.
Descritores: Qualidade de Vida
Sobreviventes/psicologia
Unidades de Terapia Intensiva
-Ansiedade/epidemiologia
Alta do Paciente
Fatores de Tempo
Brasil
Prevalência
Estudos Prospectivos
Estudos de Coortes
Seguimentos
Cuidados Críticos
Depressão/epidemiologia
Disfunção Cognitiva/epidemiologia
Limites: Humanos
Tipo de Publ: Estudo Multicêntrico
Responsável: BR1.1 - BIREME


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Bastos, Marcus Gomes
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Id: lil-777500
Autor: Paraizo, Marilise de Andrade; Almeida, Ana Laura Maciel; Pires, Leopoldo Antônio; Abrita, Renata Silva Almeida; Crivellari, Mary Hellen Teixeira; Pereira, Beatriz dos Santos; Fernandes, Natália Maria da Silva; Bastos, Marcus Gomes.
Título: Montreal Cognitive Assessment (MoCA) no rastreio de comprometimento cognitivo leve (CCL) em pacientes com doença renal crônica (DRC) pré-dialítica / Montreal Cognitive Assessment (MoCA) screening mild cognitive impairment in patients with chronic kidney disease (CKD) pre-dialysis
Fonte: J. bras. nefrol;38(1):31-41, jan.-mar. 2016. tab.
Idioma: pt.
Resumo: Resumo Introdução: Indivíduos com doença renal crônica (DRC) têm grande risco de desenvolver comprometimento cognitivo (CC), inicialmente leve (CCL), passível de identificação, mas ainda subdiagnosticado e subtratado. O Montreal Cognitive Assessment (MoCA) vem sendo indicado para rastreio de CCL na DRC. Objetivo: Avaliar o CCL em indivíduos com DRC pré-dialítica. Métodos: O estudo foi realizado em 72 indivíduos, não idosos, com DRC nos estágios pré-dialíticos. A avaliação neuropsicológica incluiu: o teste de cognição global MoCA; o teste do relógio (TDR); o Digit Span ordem direta (DOD) e inversa (DOI); o teste de fluência verbal (FV), fonêmica (FAS) e semântica (animais); o punho-borda-mão (PBM); e de memória 10 figuras. Resultados: A média de idade dos participantes foi de 56,74 ± 7,63 anos, com predominância de homens (55,6%), com escolaridade ≥ 4 anos (84,3%), a maioria com DRC 1, 2 e 3a e 3b (67,6%), hipertensa (93,1%) e diabética (52,1%). O CC (MoCA ≤ 24) foi observado em 73,6% dos usuários. Não encontramos associação das variáveis demográficas e clínicas com CC, mas tendência de associação com a idade (p = 0,07), com a escolaridade (p = 0,06) e com o DM (0,06). Os testes de função executiva, TDR, DOI e PBM, isoladamente, apresentaram boa sensibilidade e valor preditivo negativo comparados ao MoCA para a identificação de CC e, em conjunto, foram capazes de predizer o resultado do MoCA. Conclusão: O CCL é frequente em usuários não idosos com DRC pré-dialítica. O TDR, DOI e PBM associados são equivalentes ao MoCA na identificação do CC nessa população, sugerindo comprometimento de funções executivas.

Abstract Introduction: Individuals with chronic kidney disease (CKD) are at higher risk of developing cognitive impairment (CI), initially mild (MCI), potentially identifiable, but still poorly diagnosed and treated. The Montreal Cognitive Assessment (MoCA) has been indicated for MCI screening in CKD. Objective: To assess MCI in patients with CKD not yet on dialysis. Methods: Study conducted in 72 non-elderly subjects with pre-dialysis CKD. The neuropsychological assessment included: The global cognitive assessment test MoCA; the clock drawing (CD); the digit span forward (DSF) and reverse (DSR); phonemic verbal (VF) fluency (FAS) and semantics (animals); the fist-edge-palm (FEP); and the memory 10 pictures. Results: The average age of the participants was 56.74 ± 7.63 years, with predominance of male sex (55.6%), mainly with ≥ 4 years of education (84.3%), with CKD cathegories 1, 2 and 3a and 3b (67.6%), hypertension (93.1%) and diabetes mellitus (52.1%). MCI (MoCA ≤ 24) was observed in 73.6% of the patients. We did not find association among MCI with demographic and clinical variables, but a tendency to association with age (p = 0.07), educational level (p= 0.06) and diabetes (0.06). The executive function tests CD, DS-reverse and FEP, individually were able to identify CI with good sensibility and negative predictive value compared to MoCA and together, showed the same capability to identify MCI when compared to MoCA. Conclusion: The MCI is common in non-elderly patients with CKD not yet on dialysis. Together, the CD, DSR and FEP showed similar performance in identify MCI in this population when compared to MoCA, suggesting impairment of executive functions.
Descritores: Insuficiência Renal Crônica/complicações
Disfunção Cognitiva/diagnóstico
-Estudos Transversais
Diálise Renal
Cognição
Função Executiva
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adulto
Pessoa de Meia-Idade
Responsável: BR1.1 - BIREME


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Id: biblio-1097081
Autor: Viscaíno-Salazar, Gilberto J(edt).
Título: Homocisteína y trastornos neurocognitivos. ¿Una luz al final del túnel? / Homocysteine and neurocognitive disorders. A light at the end of the tunnel?
Fonte: Med. lab;24(2):111-129, 2020.
Idioma: es.
Resumo: El deterioro cognitivo es uno de los procesos que acompañan al envejecimiento y puede depender de factores nutricionales, genéticos o ambientales. La identificación de factores de riesgo modificables proporciona un enfoque esencial para la prevención de dicho deterioro y de los trastornos neurocognitivos. Uno de los factores de riesgo involucrados es la elevada concentración de homocisteína plasmática, la cual se ha relacionado con hallazgos histopatológicos en demencia senil y enfermedad de Alzheimer. Los diferentes estudios sobre esta asociación revelan inconsistencia o contradicción en los resultados. El propósito de esta revisión es relacionar la posible interacción de tres factores en la instalación y progresión del deterioro neurocognitivo: a) factores de tipo nutricional (homocisteína, ácido fólico y vitamina B12), b) la utilización de pruebas para el diagnóstico de disfunción o deterioro cognitivo como el Mini Examen del Estado Mental, y c) la presencia de variantes genéticas polimórficas de la enzima metilentetrahidrofolato reductasa. Una consecuencia directa de esta triple relación es que el tratamiento con ácido fólico y vitamina B12 logra disminuir las elevadas concentraciones de homocisteína plasmática, asumiendo que una mejoría en los síntomas clínicos de deterioro cognitivo puede retrasar los cambios relacionados con progresión a estados demenciales. La intervención temprana mediante políticas de promoción y prevención de la salud mental puede ser efectiva si se comienza con la administración de ácido fólico y vitamina B12 en los estadios iniciales de la alteración cognitiva, logrando así reducir sus funestas consecuencias. Las políticas de salud pública centradas en la salud mental de ancianos pueden identificar a las personas con disfunción cognitiva inicial a través de la promoción de la salud y medidas preventivas; en esta etapa puede ser posible la administración de vitaminas B para reducir o minimizar la progresión del deterioro cognitivo, que podría conducir a trastornos neurocognitivos como la demencia y la enfermedad de Alzheimer

Cognitive impairment is one of the processes that accompany aging and may depend on nutritional, genetic or environmental factors. The identification of modifiable risk factors provides a crucial approach for the prevention of cognitive decline and neurocognitive disorders. One of the risk factors is the high concentration of plasma homocysteine and it has been associated to histopathological changes in senile dementia and Alzheimer´s disease. Clinical trials about this association has shown inconsistent and contradictory results. The purpose of this review is to describe the possible interaction of three factors related with cognitive impairment: a) nutritional factors (homocysteine, folic acid and vitamin B12), b) the use of mental tests such as the Mini Mental State Examination for the diagnosis of cognitive dysfunction, and c) the presence of polymorphic genetic variants of the methylenetetrahydrofolate reductase enzyme. A direct consequence of this triple relationship is the treatment with folic acid and vitamin B12, which decrease high concentrations of plasma homocysteine, with a potential for improvement of the clinical symptoms of cognitive decline, and possibly a delay in the progression towards neurocognitive disorder. Public health policies focused on mental health of older adults can identify people with initial cognitive dysfunction through health promotion and preventive measures, where it can be possible to administer B vitamins in order to reduce or minimize the progression of cognitive decline, that could lead to mental disturbances such as neurocognitive disorders
Descritores: Homocisteína
-Vitamina B 12
Vitamina B 6
Demência
Doença de Alzheimer
Disfunção Cognitiva
Ácido Fólico
Tipo de Publ: Revisão
Responsável: CO373.9 - EDIMECO - Editora Médica Colombiana S.A.


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Id: biblio-1096954
Autor: Bedoya Cardona, Erika Yohanna; Ardilla Rodríguez, William Alexander; Cañas Betancur, Dora Cristina; Vásquez Caballero, Diego Andrés.
Título: Estrés y deterioro cognitivo en pacientes con diagnóstico de esquizofrenia / Stress and cognitive impairment in patients with diagnosis of schizophrenia
Fonte: Rev. chil. neuropsicol. (En línea);12(2):8-13, dic. 2017. tab.
Idioma: es.
Resumo: El presente es un estudio no experimental, transversal y correlacional, cuyo objetivo era determinar si existe relación entre estrés y deterioro cognitivo en personas con diagnóstico de esquizofrenia, confirmar si la depresión y las estrategias de afrontamiento del estrés se relacionan y si son factores moderadores de la relación entre estrés y deterioro cognitivo, mediante la evaluación y descripción del estrés percibido (PSS), estrategias de afrontamiento del estrés (CSI), depresión (CDSS) y deterioro cognitivo (MoCA), en una muestra de 43 pacientes con diagnóstico de esquizofrenia (36 hombres y 7 mujeres) entre los 16 y 65 años, de Bucaramanga y Medellín (Colombia), seleccionados mediante muestreo no probabilístico por conveniencia. Se encontró que el grupo presenta niveles medios de estrés percibido y puntuaciones medias y bajas en estrategias de afrontamiento adecuadas e inadecuadas, casi la mitad presenta riesgo de comorbilidad con depresión y la mayoría presenta deterioro cognitivo. No se encontró relación entre deterioro cognitivo con las demás variables. Estrés se relaciona significativamente con depresión y con estrategias de afrontamiento expresión emocional, retirada social y autocrítica. Finalmente, depresión correlacionó significativamente con estrategias de afrontamiento expresión emocional y retirada social. Aunque estos hallazgos no pueden ser concluyentes ni generalizables debido a limitaciones metodológicas, pueden ser usados como antecedente para futuros estudios.

The present is a non-experimental, cross-sectional and correlational study, whose objective was to determine if there is a relationship between stress and cognitive impairment in people diagnosed with schizophrenia, to confirm whether depression and coping strategies are related and if they are moderating factors of the relationship between stress and cognitive impairment, through the evaluation and description of perceived stress (PSS), stress coping strategies (CSI), depression (CDSS) and cognitive impairment (MoCA), in a sample of 43 patients diagnosed with schizophrenia (36 men and 7 women) between 16 and 65 years old, from Bucaramanga and Medellín (Colombia), selected by non-probabilistic for convenience sampling. It was found that the group in average presents a medium level of perceived stress, and average and low scores in appropriate and inadequate coping strategies, almost half presents risk of comorbidity with depression, and most of them present cognitive impairment. No relationship was found between cognitive impairment with the other variables. Stress is significantly related to depression and coping strategies as emotional expression, social withdrawal and self-criticism. Finally, depression correlated significantly with coping strategies as emotional expression and social withdrawal. Although these findings cannot be conclusive or generalizable due to methodological limitations, they can be used as a precedent for future studies.
Descritores: Esquizofrenia
Estresse Psicológico
Disfunção Cognitiva/psicologia
-Epidemiologia Experimental
Estudos Transversais
Correlação de Dados
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Responsável: CL58.1 - Biblioteca


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Id: lil-792747
Autor: de Paula, Jonas J; Albuquerque, Maicon R; Lage, Guilherme M; Bicalho, Maria A; Romano-Silva, Marco A; Malloy-Diniz, Leandro F.
Título: Impairment of fine motor dexterity in mild cognitive impairment and alzheimer's disease dementia: association with activities of daily living
Fonte: Rev. bras. psiquiatr;38(3):235-238, July-Sept. 2016. graf.
Idioma: en.
Resumo: Objective: Cognitive impairment is a hallmark of mild cognitive impairment (MCI) and Alzheimer’s disease dementia (AD). Although the cognitive profile of these patients and its association with activities of daily living (ADLs) is well documented, few studies have assessed deficits in fine motor dexterity and their association with ADL performance. The objective of this research paper is to evaluate fine motor dexterity performance among MCI and AD patients and to investigate its association with different aspects of ADLs. Methods: We assessed normal aging controls, patients with multiple- and single-domain amnestic MCI (aMCI), and patients with mild AD. Fine motor dexterity was measured with the Nine-Hole Peg Test and cognitive functioning by the Mattis Dementia Rating Scale. We analyzed the data using general linear models. Results: Patients with AD or multiple-domain aMCI had slower motor responses when compared to controls. AD patients were slower than those with single-domain aMCI. We found associations between cognition and instrumental ADLs, and between fine motor dexterity and self-care ADLs. Conclusion: We observed progressive slowing of fine motor dexterity along the normal aging-MCI-AD spectrum, which was associated with autonomy in self-care ADLs.
Descritores: Atividades Cotidianas/psicologia
Doença de Alzheimer/fisiopatologia
Disfunção Cognitiva/fisiopatologia
Destreza Motora/fisiologia
-Escalas de Graduação Psiquiátrica
Autocuidado/psicologia
Envelhecimento/fisiologia
Envelhecimento/psicologia
Estudos de Casos e Controles
Modelos Lineares
Estudos Transversais
Testes Neuropsicológicos
Limites: Humanos
Responsável: BR1.1 - BIREME


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Id: lil-792746
Autor: Coutinho, Gabriel; Drummond, Cláudia; Teldeschi, Alina; Mattos, Paulo.
Título: Awareness of memory deficits is useful to distinguish between depression and mild cognitive impairment in the elderly
Fonte: Rev. bras. psiquiatr;38(3):231-234, July-Sept. 2016. tab.
Idioma: en.
Resumo: Objective: To investigate whether the level of awareness of memory deficits is useful for discriminating between major depressive disorder (MDD) and mild cognitive impairment (MCI) in the elderly. Methods: Sixty-three consecutively referred patients (38 women and 25 men) with memory concerns comprising three groups (clinical control, MDD and MCI) underwent a memory test (Rey Auditory Verbal Learning Test [RAVLT]) and completed the Memory Assessment Complaints-Questionnaire (MAC-Q). Level of awareness was estimated by the difference between the MAC-Q score and the score on the fifth presentation of the RAVLT. Memory performance, Mini-Mental State Examination (MMSE) and depressive symptoms (Geriatric Depression Scale [GDS]) were also assessed. Results: The control (n=25), MDD (n=16), and MCI (n=22) groups were similar in age, educational level, and MMSE (p > 0.05). Among the groups, the MDD group had the most memory complaints, whereas the MCI group had the worst objective memory performance. Level of awareness was capable of discriminating between MDD and MCI (p < 0.05), but not between MDD and clinical controls (p > 0.05). MDD subjects tended to underestimate their memory functioning as compared to controls (p < 0.05). Conclusion: Level of awareness of memory deficits was significantly useful to discriminate between MCI and MDD, which is a common difficulty faced by clinicians. Future studies with larger samples are needed to confirm these findings.
Descritores: Conscientização
Transtorno Depressivo Maior/diagnóstico
Disfunção Cognitiva/diagnóstico
Transtornos da Memória/diagnóstico
-Estudos de Casos e Controles
Valor Preditivo dos Testes
Inquéritos e Questionários
Análise de Variância
Estatísticas não Paramétricas
Transtorno Depressivo Maior/fisiopatologia
Diagnóstico Diferencial
Disfunção Cognitiva/fisiopatologia
Transtornos da Memória/fisiopatologia
Pessoa de Meia-Idade
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Idoso
Idoso de 80 Anos ou mais
Responsável: BR1.1 - BIREME


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Id: lil-792744
Autor: Gomes, July S; Ducos, Daniella V; Akiba, Henrique; Dias, Álvaro M.
Título: A neurofeedback protocol to improve mild anxiety and sleep quality
Fonte: Rev. bras. psiquiatr;38(3):264-265, July-Sept. 2016. tab.
Idioma: en.
Projeto: FAPESP.
Descritores: Transtornos de Ansiedade/fisiopatologia
Transtornos de Ansiedade/terapia
Sono/fisiologia
Neurorretroalimentação/métodos
-Escala de Ansiedade Frente a Teste
Fatores de Tempo
Resultado do Tratamento
Depressão/fisiopatologia
Depressão/terapia
Eletroencefalografia/métodos
Disfunção Cognitiva/fisiopatologia
Disfunção Cognitiva/terapia
Limites: Humanos
Feminino
Adulto
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: lil-792743
Autor: Kapczinski, Natalia S; Narvaez, Joana C; Magalhães, Pedro V; Bücker, Joana; Peuker, Ana C; Loredo, Ana C; Troiano, Federico; Czepielewski, Letícia; Rosa, Adriane; Fries, Gabriel R; Gama, Clarissa S.
Título: Cognition and functioning in bipolar depression
Fonte: Rev. bras. psiquiatr;38(3):201-206, July-Sept. 2016. tab, graf.
Idioma: en.
Resumo: Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p < 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.
Descritores: Transtorno Bipolar/fisiopatologia
Depressão/fisiopatologia
Disfunção Cognitiva/fisiopatologia
-Escalas de Graduação Psiquiátrica
Índice de Gravidade de Doença
Estudos de Casos e Controles
Análise de Variância
Cognição/fisiologia
Função Executiva/fisiologia
Memória de Curto Prazo/fisiologia
Pessoa de Meia-Idade
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: lil-792742
Autor: Cruz, Breno F; Resende, Camilo B. de; Carvalhaes, Carolina F; Cardoso, Clareci S; Teixeira, Antonio L; Keefe, Richard S; Rocha, Fábio L; Salgado, João V.
Título: Interview-based assessment of cognition is a strong predictor of quality of life in patients with schizophrenia and severe negative symptoms
Fonte: Rev. bras. psiquiatr;38(3):216-221, July-Sept. 2016. tab, graf.
Idioma: en.
Resumo: Objective: To analyze the correlation between quality of life, symptoms, and cognition assessed by the interview-based Schizophrenia Cognition Rating Scale (SCoRS). Methods: Seventy-nine outpatients diagnosed with schizophrenia were evaluated with the Quality of Life Scale – Brazilian version (QLS-BR), the SCoRS, and symptoms scales (Positive and Negative Syndrome Scale [PANSS]). After determining the potential explanatory variables using Spearman’s correlation and Student’s t test results, we ran simple, multivariate, and decision-tree regression analyses to assess the impact of SCoRS and PANSS ratings on mean overall quality of life. Results: Cognitive deficits and negative symptoms were the best predictors of quality of life. A low degree of negative symptoms (PANSS negative < 11) was a strong predictor of better quality of life (QLS ∼ 75), regardless of SCoRS rating. Among participants with more severe negative symptoms, elevated cognitive impairment (interviewer SCoRS ∼ 44) was a predictor of worse quality of life (QLS ∼ 44). Conclusions: Cognitive impairment determined by interview-based assessment seems to be a strong predictor of quality of life in subjects with severe negative symptoms. These results support the usefulness of SCoRS for cognitive assessment that is relevant to the everyday life of patients with schizophrenia.
Descritores: Escalas de Graduação Psiquiátrica
Qualidade de Vida/psicologia
Esquizofrenia/fisiopatologia
Disfunção Cognitiva/fisiopatologia
-Psicometria
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
Índice de Gravidade de Doença
Brasil
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Análise de Variância
Estatísticas não Paramétricas
Pessoa de Meia-Idade
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: biblio-1011501
Autor: Fonseca, Luciana M; Haddad, Glenda G; Mattar, Guilherme P; Oliveira, Melaine C. de; Simon, Sharon S; Guilhoto, Laura M; Busatto, Geraldo F; Zaman, Shahid; Holland, Anthony J; Hoexter, Marcelo Q; Bottino, Cassio M.
Título: The validity and reliability of the CAMDEX-DS for assessing dementia in adults with Down syndrome in Brazil
Fonte: Braz. J. Psychiatry (São Paulo, 1999, Impr.);41(3):225-233, May-June 2019. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Objective: Alzheimer's disease occurs at a higher prevalence and an earlier age in individuals with Down syndrome (DS) than typically developing individuals. However, diagnosing dementia in individuals with intellectual disability remains a challenge due to pre-existing cognitive deficits. The aim of this study was to investigate the validity and reliability of the Brazilian version of the Cambridge Examination for Mental Disorders of Older People with Down's syndrome and Others with Intellectual Disabilities (CAMDEX-DS) for individuals with DS. Methods: Two psychiatrists, working independently, evaluated 92 adults with DS ≥ 30 years of age. The concurrent validity of the CAMDEX-DS was analyzed in relation to the gold standard of established international criteria. In a subgroup of 20 subjects, the concurrent validity of the CAMDEX-DS was analyzed in relation to an independent objective assessment of cognitive decline over three years. We analyzed the inter-rater reliability of cognitive assessment. Results: The diagnostic accuracy of the CAMDEX-DS compared to the gold standard was 96.7%. CAMDEX-DS-based diagnosis was considered consistent with cognitive decline. The probability of a participant with dementia having cognitive decline was 83%. Inter-rater reliability for the participant assessment was good, with a kappa of > 0.8 for 93% of the CAMDEX-DS items. Conclusion: The CAMDEX-DS can be considered the first valid and reliable instrument for evaluating dementia in adults with DS in Brazil. Its use in such individuals could improve clinical practice and research.
Descritores: Síndrome de Down/diagnóstico
Demência/diagnóstico
Disfunção Cognitiva/diagnóstico
Testes Neuropsicológicos
-Tradução
Brasil/epidemiologia
Métodos Epidemiológicos
Síndrome de Down/complicações
Síndrome de Down/epidemiologia
Demência/complicações
Demência/epidemiologia
Deficiência Intelectual
Pessoa de Meia-Idade
Limites: Humanos
Adulto
Tipo de Publ: Estudo de Validação
Responsável: BR1.1 - BIREME



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