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Pesquisa : F03.700.750 [Categoria DeCS]
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Id: biblio-1096954
Autor: Bedoya Cardona, Erika Yohanna; Ardilla Rodríguez, William Alexander; Cañas Betancur, Dora Cristina; Vásquez Caballero, Diego Andrés.
Título: Estrés y deterioro cognitivo en pacientes con diagnóstico de esquizofrenia / Stress and cognitive impairment in patients with diagnosis of schizophrenia
Fonte: Rev. chil. neuropsicol. (En línea);12(2):8-13, dic. 2017. tab.
Idioma: es.
Resumo: El presente es un estudio no experimental, transversal y correlacional, cuyo objetivo era determinar si existe relación entre estrés y deterioro cognitivo en personas con diagnóstico de esquizofrenia, confirmar si la depresión y las estrategias de afrontamiento del estrés se relacionan y si son factores moderadores de la relación entre estrés y deterioro cognitivo, mediante la evaluación y descripción del estrés percibido (PSS), estrategias de afrontamiento del estrés (CSI), depresión (CDSS) y deterioro cognitivo (MoCA), en una muestra de 43 pacientes con diagnóstico de esquizofrenia (36 hombres y 7 mujeres) entre los 16 y 65 años, de Bucaramanga y Medellín (Colombia), seleccionados mediante muestreo no probabilístico por conveniencia. Se encontró que el grupo presenta niveles medios de estrés percibido y puntuaciones medias y bajas en estrategias de afrontamiento adecuadas e inadecuadas, casi la mitad presenta riesgo de comorbilidad con depresión y la mayoría presenta deterioro cognitivo. No se encontró relación entre deterioro cognitivo con las demás variables. Estrés se relaciona significativamente con depresión y con estrategias de afrontamiento expresión emocional, retirada social y autocrítica. Finalmente, depresión correlacionó significativamente con estrategias de afrontamiento expresión emocional y retirada social. Aunque estos hallazgos no pueden ser concluyentes ni generalizables debido a limitaciones metodológicas, pueden ser usados como antecedente para futuros estudios.

The present is a non-experimental, cross-sectional and correlational study, whose objective was to determine if there is a relationship between stress and cognitive impairment in people diagnosed with schizophrenia, to confirm whether depression and coping strategies are related and if they are moderating factors of the relationship between stress and cognitive impairment, through the evaluation and description of perceived stress (PSS), stress coping strategies (CSI), depression (CDSS) and cognitive impairment (MoCA), in a sample of 43 patients diagnosed with schizophrenia (36 men and 7 women) between 16 and 65 years old, from Bucaramanga and Medellín (Colombia), selected by non-probabilistic for convenience sampling. It was found that the group in average presents a medium level of perceived stress, and average and low scores in appropriate and inadequate coping strategies, almost half presents risk of comorbidity with depression, and most of them present cognitive impairment. No relationship was found between cognitive impairment with the other variables. Stress is significantly related to depression and coping strategies as emotional expression, social withdrawal and self-criticism. Finally, depression correlated significantly with coping strategies as emotional expression and social withdrawal. Although these findings cannot be conclusive or generalizable due to methodological limitations, they can be used as a precedent for future studies.
Descritores: Esquizofrenia
Estresse Psicológico
Disfunção Cognitiva/psicologia
-Epidemiologia Experimental
Estudos Transversais
Correlação de Dados
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Responsável: CL58.1 - Biblioteca


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Id: lil-792742
Autor: Cruz, Breno F; Resende, Camilo B. de; Carvalhaes, Carolina F; Cardoso, Clareci S; Teixeira, Antonio L; Keefe, Richard S; Rocha, Fábio L; Salgado, João V.
Título: Interview-based assessment of cognition is a strong predictor of quality of life in patients with schizophrenia and severe negative symptoms
Fonte: Rev. bras. psiquiatr;38(3):216-221, July-Sept. 2016. tab, graf.
Idioma: en.
Resumo: Objective: To analyze the correlation between quality of life, symptoms, and cognition assessed by the interview-based Schizophrenia Cognition Rating Scale (SCoRS). Methods: Seventy-nine outpatients diagnosed with schizophrenia were evaluated with the Quality of Life Scale – Brazilian version (QLS-BR), the SCoRS, and symptoms scales (Positive and Negative Syndrome Scale [PANSS]). After determining the potential explanatory variables using Spearman’s correlation and Student’s t test results, we ran simple, multivariate, and decision-tree regression analyses to assess the impact of SCoRS and PANSS ratings on mean overall quality of life. Results: Cognitive deficits and negative symptoms were the best predictors of quality of life. A low degree of negative symptoms (PANSS negative < 11) was a strong predictor of better quality of life (QLS ∼ 75), regardless of SCoRS rating. Among participants with more severe negative symptoms, elevated cognitive impairment (interviewer SCoRS ∼ 44) was a predictor of worse quality of life (QLS ∼ 44). Conclusions: Cognitive impairment determined by interview-based assessment seems to be a strong predictor of quality of life in subjects with severe negative symptoms. These results support the usefulness of SCoRS for cognitive assessment that is relevant to the everyday life of patients with schizophrenia.
Descritores: Escalas de Graduação Psiquiátrica
Qualidade de Vida/psicologia
Esquizofrenia/fisiopatologia
Disfunção Cognitiva/fisiopatologia
-Psicometria
Esquizofrenia/diagnóstico
Psicologia do Esquizofrênico
Índice de Gravidade de Doença
Brasil
Valor Preditivo dos Testes
Reprodutibilidade dos Testes
Análise de Variância
Estatísticas não Paramétricas
Pessoa de Meia-Idade
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME


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Id: lil-784308
Autor: Berberian, Arthur A; Moraes, Giovanna V; Gadelha, Ary; Brietzke, Elisa; Fonseca, Ana O; Scarpato, Bruno S; Vicente, Marcella O; Seabra, Alessandra G; Bressan, Rodrigo A; Lacerda, Acioly L.
Título: Is semantic verbal fluency impairment explained by executive function deficits in schizophrenia?
Fonte: Rev. bras. psiquiatr;38(2):121-126, Apr.-June 2016. tab.
Idioma: en.
Projeto: FAPESP.
Resumo: Objective: To investigate if verbal fluency impairment in schizophrenia reflects executive function deficits or results from degraded semantic store or inefficient search and retrieval strategies. Method: Two groups were compared: 141 individuals with schizophrenia and 119 healthy age and education-matched controls. Both groups performed semantic and phonetic verbal fluency tasks. Performance was evaluated using three scores, based on 1) number of words generated; 2) number of clustered/related words; and 3) switching score. A fourth performance score based on the number of clusters was also measured. Results: SZ individuals produced fewer words than controls. After controlling for the total number of words produced, a difference was observed between the groups in the number of cluster-related words generated in the semantic task. In both groups, the number of words generated in the semantic task was higher than that generated in the phonemic task, although a significant group vs. fluency type interaction showed that subjects with schizophrenia had disproportionate semantic fluency impairment. Working memory was positively associated with increased production of words within clusters and inversely correlated with switching. Conclusion: Semantic fluency impairment may be attributed to an inability (resulting from reduced cognitive control) to distinguish target signal from competing noise and to maintain cues for production of memory probes.
Descritores: Esquizofrenia/complicações
Semântica
Função Executiva/fisiologia
Transtornos da Linguagem/etiologia
-Comportamento Verbal/fisiologia
Fonética
Estudos de Casos e Controles
Transtornos da Linguagem/diagnóstico
Memória de Curto Prazo
Pessoa de Meia-Idade
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: lil-784296
Autor: Javelot, Hervé; Michel, Bruno; Kumar, Divya; Audibert, Brigitte.
Título: Clozapine-induced esophagitis at therapeutic dose: a case report
Fonte: Rev. bras. psiquiatr;38(2):177-177, Apr.-June 2016. tab.
Idioma: en.
Descritores: Antipsicóticos/efeitos adversos
Clozapina/efeitos adversos
Esofagite/induzido quimicamente
-Esquizofrenia/tratamento farmacológico
Antipsicóticos/administração & dosagem
Clozapina/administração & dosagem
Quimioterapia Combinada
Pessoa de Meia-Idade
Limites: Humanos
Masculino
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-844173
Autor: Gabínio, Thalita; Ricci, Thaysse G; Kahn, Jeffrey P; Malaspina, Dolores; Veras, André B.
Título: Panic psychosis: paroxysmal panic anxiety concomitant with auditory hallucinations in schizophrenia
Fonte: Rev. bras. psiquiatr;39(1):85-86, Jan.-Mar. 2017.
Idioma: en.
Descritores: Transtornos Psicóticos/psicologia
Esquizofrenia/tratamento farmacológico
Transtorno de Pânico/psicologia
Alucinações/psicologia
-Ansiedade/psicologia
Transtornos Psicóticos/tratamento farmacológico
Psicologia do Esquizofrênico
Antipsicóticos/uso terapêutico
Transtorno de Pânico/tratamento farmacológico
Alucinações/tratamento farmacológico
Limites: Humanos
Feminino
Pessoa de Meia-Idade
Tipo de Publ: Relatos de Casos
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-844169
Autor: Ruiz-Veguilla, Miguel; Moreno-Granados, Josefa; Salcedo-Marin, Maria D; Barrigon, Maria L; Blanco-Morales, Maria J; Igunza, Evelio; Cañabate, Anselmo; Garcia, Maria D; Guijarro, Teresa; Diaz-Atienza, Francisco; Ferrin, Maite.
Título: Sex-specific cognitive abnormalities in early-onset psychosis
Fonte: Rev. bras. psiquiatr;39(1):28-35, Jan.-Mar. 2017. tab, graf.
Idioma: en.
Projeto: BAE.
Resumo: Objectives: Brain maturation differs depending on the area of the brain and sex. Girls show an earlier peak in maturation of the prefrontal cortex. Although differences between adult females and males with schizophrenia have been widely studied, there has been less research in girls and boys with psychosis. The purpose of this study was to examine differences in verbal and visual memory, verbal working memory, auditory attention, processing speed, and cognitive flexibility between boys and girls. Methods: We compared a group of 80 boys and girls with first-episode psychosis to a group of controls. Results: We found interactions between group and sex in verbal working memory (p = 0.04) and auditory attention (p = 0.01). The female controls showed better working memory (p = 0.01) and auditory attention (p = 0.001) than males. However, we did not find any sex differences in working memory (p = 0.91) or auditory attention (p = 0.93) in the psychosis group. Conclusions: These results are consistent with the presence of sex-modulated cognitive profiles at first presentation of early-onset psychosis.
Descritores: Esquizofrenia/fisiopatologia
Fatores Sexuais
Transtornos Cognitivos/fisiopatologia
-Psicologia do Esquizofrênico
Estudos de Casos e Controles
Córtex Pré-Frontal
Transtornos Cognitivos/psicologia
Memória de Curto Prazo
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Criança
Adolescente
Responsável: BR1.1 - BIREME


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Id: biblio-899382
Autor: Grassmann, Viviane; Subramaniapillai, Mehala; Duncan, Mark; Arbour-Nicitopoulos, Kelly; Faulkner, Guy E.
Título: The relationship between moderate-to-vigorous physical activity and executive function among individuals with schizophrenia: differences by illness duration
Fonte: Rev. bras. psiquiatr;39(4):309-315, Oct.-Dec. 2017. tab.
Idioma: en.
Projeto: CNPq.
Resumo: Objective: Schizophrenia is a chronic mental illness characterized by positive and negative symptoms. Cognitive impairment continues to be a core and consistent deficit. Previous studies have shown that physical activity (PA) is positively associated with cognitive performance. Thus, it may play a supportive role in mitigating cognitive impairments among individuals with schizophrenia. The aim of this study was to analyze the relationship between moderate-to-vigorous physical activity (MVPA) and executive function among adults with schizophrenia. Methods: The weekly amount of MVPA (assessed using accelerometers) and executive function (as per Brief Neurocognitive Assessment for Schizophrenia) of 78 adults with schizophrenia (mean [SD] age 42.4 [11.4] years; illness duration 17.0 [11.0] years; 58.2% male) were assessed in this cross-sectional study. Pearson correlations were calculated, followed by a linear regression. Participants were first analyzed together and then dichotomized on the basis of illness duration. Results: There was no significant association between MVPA and executive function, independent of the duration of illness. For individuals with < 15 years of illness, there was a significant association between weekly MVPA and working memory performance. Conclusion: PA appears to be associated with executive function in some, but not all, individuals with schizophrenia.
Descritores: Esquizofrenia/fisiopatologia
Exercício Físico/fisiologia
Função Executiva/fisiologia
-Esquizofrenia/tratamento farmacológico
Antipsicóticos/uso terapêutico
Clorpromazina/uso terapêutico
Estudos Transversais
Escolaridade
Função Executiva/efeitos dos fármacos
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Pessoa de Meia-Idade
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-899376
Autor: Okusaga, Olaoluwa O.
Título: Trajectory of brain maturation and sex-specific cognitive abnormalities in early-onset psychosis
Fonte: Rev. bras. psiquiatr;39(4):381-381, Oct.-Dec. 2017.
Idioma: en.
Descritores: Transtornos Psicóticos
Esquizofrenia
-Encéfalo
Cognição
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Comentário
Carta
Responsável: BR1.1 - BIREME


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Id: biblio-899372
Autor: Caye, Arthur; Kieling, Renata R; Rocha, Thiago B; Graeff-Martins, Ana S; Geyer, Cristiane; Krieger, Fernanda; Manfro, Gisele G; Brentani, Helena; Isolan, Luciano; Rosário, Maria C; Grassi-Oliveira, Rodrigo; Caetano, Sheila C; Moriyama, Tais; Rohde, Luis A; Kieling, Christian.
Título: Schedule for Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime Version (K-SADS-PL), DSM-5 update: translation into Brazilian Portuguese
Fonte: Rev. bras. psiquiatr;39(4):384-386, Oct.-Dec. 2017. tab.
Idioma: en.
Descritores: Esquizofrenia/diagnóstico
Traduções
Transtornos do Humor/diagnóstico
Entrevista Psiquiátrica Padronizada/normas
-Tradução
Brasil
Limites: Humanos
Pré-Escolar
Criança
Adolescente
Tipo de Publ: Carta
Responsável: BR1.1 - BIREME


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Id: biblio-899370
Autor: Matsuzaka, Camila T; Christofolini, Denise; Ota, Vanessa K; Gadelha, Ary; Berberian, Arthur A; Noto, Cristiano; Mazzotti, Diego R; Spindola, Leticia M; Moretti, Patricia N; Smith, Marilia A C; Melaragno, Maria I; Belangero, Sintia I; Bressan, Rodrigo A.
Título: Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls
Fonte: Rev. bras. psiquiatr;39(4):302-308, Oct.-Dec. 2017. tab, graf.
Idioma: en.
Projeto: FAPESP.
Resumo: Objective: Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. Methods: We evaluated the role of three COMT SNPs (rs737865, rs165599, and rs4680) in schizophrenia and their impact on three working memory tasks. For genetic association analyses, 212 individuals with schizophrenia and 257 healthy controls (HCs) were selected. The Visual Working Memory (VWM) Task, Keep Track Task, and Letter Memory Task were administered to 133 schizophrenics and 93 HCs. Results: We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia. COMT rs4680 AA carriers and rs737865 AA carriers scored lowest on the Keep Track Task. When the genotype*group interaction effect was evaluated, rs165599 exerted opposite effects for VWM and Keep Track task performance in patients and controls, with AA carriers scoring lowest on both tests among controls, but highest among patients. Conclusion: These data support the hypothesis that COMT polymorphisms may be associated with schizophrenia and modulate cognition in patients and controls.
Descritores: Esquizofrenia/genética
Catecol O-Metiltransferase/genética
Córtex Pré-Frontal/metabolismo
Memória de Curto Prazo/fisiologia
-Fenótipo
Esquizofrenia/fisiopatologia
Esquizofrenia/metabolismo
Haplótipos
Catecol O-Metiltransferase/metabolismo
Estudos de Casos e Controles
Predisposição Genética para Doença
Polimorfismo de Nucleotídeo Único/genética
Frequência do Gene
Genótipo
Testes Neuropsicológicos
Limites: Humanos
Masculino
Feminino
Adulto
Responsável: BR1.1 - BIREME



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