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Id: biblio-1370225
Autor: Ministerio de Salud de Peru. Dirección General de Intervenciones Estratégicas en Salud Pública, Dirección de Prevención y Control de Enfermedades No Transmisibles, Raras y Huérfanas. Unidad Funcional de Atención a Personas Expuestas a Metales Pesados y Otras Sustancias Químicas.
Título: Documento técnico de registro y codificación de la atención en la consulta externa a personas expuestas a metales pesados, metaloides y otras sustancias químicas, por curso de vida. Sistema de información HIS / Technical document for registration and coding of outpatient care for people exposed to heavy metals, metalloids and other chemical substances, by lifetime. HIS information system.
Fonte: Lima; Perú. Ministerio de Salud. Dirección General de Intervenciones Estratégicas en Salud Pública, Dirección de Prevención y Control de Enfermedades No Transmisibles, Raras y Huérfanas. Unidad Funcional de Atención a Personas Expuestas a Metales Pesados y Otras Sustancias Químicas; 2022. 18 p. ilus.
Idioma: es.
Resumo: La publicación describe la información actualizada de las atenciones integrales de salud realizadas a las personas expuestas a metales pesados, metaloides y otras sustancias químicas, por curso de vida. El Perú es un país de gran diversidad geográfica, geológica, étnica y cultural, con una variedad de actividades productivas, extractoras y de servicios (formales e informales) que generan, aparte de sus beneficios, agentes contaminantes y desechos, pasivos ambientales y otros focos de contaminación que vierten al ambiente elementos tóxicos tales como el plomo, mercurio, cadmio, arsénico, aluminio, bario, cromo, cobre, hierro, que se dispersan en el ambiente y llegan a los cuerpos de agua superficiales y subterráneas directa o indirectamente; los cuales pueden alterar procesos bioquímicos y/o fisiológicos en el organismo, por lo que brindar de manera oportuna atención integral de salud a personas expuestas a metales pesados, metaloides y otras sustancias químicas y el registro en el HIS de toda acción y/o actividad realizada desde un tamizaje clínico, apoyo al diagnóstico con laboratorio por medio de un dosaje, entrega y evaluación de resultados, diagnóstico, tratamiento, y seguimiento, contribuirá a obtener información valiosa y exacta de la atención clínica
Descritores: Fenômenos Bioquímicos
Substâncias Perigosas
Avaliação de Resultados em Cuidados de Saúde
Assistência Integral à Saúde
Substâncias Tóxicas
Poluentes Ambientais
Poluição Ambiental
Codificação Clínica
Tipo de Publ: Manual de Referência
Responsável: PE18.1 - Biblioteca Central


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Id: biblio-1363758
Autor: Mutluay, Duygu; Monsef, Yanad Abou; Tenekeci, Gözde Yücel.
Título: Evaluation of potential hepatotoxicity induced by Bortezomib
Fonte: Acta sci. vet. (Impr.);49:Pub. 1826, 2021. ilus, tab.
Idioma: en.
Resumo: Bortezomib, an inhibitor of 26S proteasome, is an anti-cancer therapeutic agent used in different cancer types. It leads to the arrest of the cancerous cell cycle by inhibiting angiogenesis and inducing apoptosis. Liver is the vital organ for detoxification and excretion of toxic products. The treatment with chemotherapy is a challenge, drugs are used to destroy cancer cells, but healthy cells can be affected during cancer treatment as well. The main objective of this study was to analyze the histopathological and biochemical effects of bortezomib on liver. Twenty-four female C57BL/6 mice were distributed into 4 groups, bortezomib injected treatment groups (Btz1, Btz2) and saline injected control groups (C1, C2). Bortezomib and saline were treated twice per week for 6 weeks and sacrificed at the end of one day (Btz1, C1) and 4 weeks (Btz2, C2) after the last injection. Liver samples were examined for histopathological analysis and the serum samples processed for biochemical analysis. Tissue samples were fixed, routinely processed, sectioned, and stained with Hematoxylin and Eosin (H&E). Periodic Acid-Schiff (PAS), Sudan Black staining and Masson's trichrome histochemical staining methods were performed to characterize the lesions. Histopathological analysis of the Btz1 and Btz2 groups revealed acute hepatic morphological changes such as hepatocellular swelling (cloudy swelling), necro-inflammatory reaction, and increased mononuclear polyploidy. Based on the negative staining with PAS and Sudan Black staining, hepatocellular swelling was diagnosed as hydropic degeneration. Necro-inflammatory reaction observed in the form of acute hepatitis was composed of mainly mononuclear cell infiltration accompanied by multifocal necrotic foci. Kupffer cell proliferation was observed in parallel with degenerative and necrotic changes. An Increase in hepatocellular mononuclear polyploidy visualized as hepatocytes with a single enlarged nucleus was detected in all liver sections of Btz1 and Btz2 groups. Individual cases of cholestasis (n = 1) and mild hepatic fibrosis (n = 1) were also reported. Significant elevated levels of alanine aminotransferase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) and gamma-glutamyl transferase (GGT) were detected in bortezomib treated groups. Few clinical cases reported liver injury related to bortezomib used for cancer treatment. However, the liver was not considered as a target for bortezomib treatment. Our data suggesting that bortezomib caused liver damage and induces elevations in serum levels. The reported hepatic lesions including hepatocellular swelling, acute hepatitis and mononuclear polyploidy were mainly mild and moderate in severity. The increase of polyploidy in liver tissue of mice treated with bortezomib in this study was explained as a reaction of the liver facing the drug-induced hepatic damage. The mechanism leading to the hepatotoxicity of bortezomib treatment is not known but the production of a toxic metabolite through its metabolism in the liver can be suggested. Moreover, no recovery was also observed in histopathological and biochemical analyses suggesting that the bortezomib effect is non-reversible four weeks after the drug was withdrawn. Patients should be informed about the possibility of acute drug-induced hepatitis and hepatotoxicity of this chemotherapeutic agent after the treatment.(AU)
Descritores: Fenômenos Bioquímicos/efeitos dos fármacos
Inibidores de Proteassoma/uso terapêutico
Bortezomib
Fígado/efeitos dos fármacos
-Camundongos
Limites: Animais
Feminino
Camundongos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1363761
Autor: L. Kennedy, María; Arrúa, Wilfrido; Taboada, Teresa; A Ibarrola, Derlis; Campuzano Bublitz, Miguel A.
Título: Effect of Prosopis ruscifolia on incretin and insulin secretion in alloxan-induced hyperglycemic rats / Efecto de Prosopis ruscifolia sobre la secreción de incretina e insulina de ratas hiperglicémicas por aloxano
Fonte: Vitae (Medellín);29(1):1-9, 2022-01-09. Ilustraciones.
Idioma: en.
Resumo: Background: Diabetes mellitus treatment is based on oral hypoglycemic agents or insulin. Medicinal plants constitute an option, and the leaves of Prosopis ruscifolia (Pr) were shown to be effective in reducing glycemia in hyperglycemic animals. Objective: In this paper, we report the effect of P. rusciofolia (Pr) on insulin and incretin secretion in alloxan-induced hyperglycemic rats. Methodology: The effective dose was selected, and four groups (n=10) of Wistar rats were used. Two groups with normal glycemia received water or Pr (75 mg/Kg, per os, p.o.), and two groups with hyperglycemia induced by alloxan (intraperitoneal, ip), received water or Pr (75 mg/Kg, p.o.) for 2 weeks. Oral glucose tolerance test, and incretin and insulin levels were measured at the end of the experimental period. Results: The results showed that extract promotes better tolerance to oral glucose overload, in addition to a statistically significant (p<0.001) increase in blood levels of incretin and insulin, compared to the hyperglycemic rats. Conclusion: It is concluded that the ethanolic extract of P. ruscifolialeaves has a hypoglycemic effect in hyperglycemic animals by a mechanism that involves the incretin-insulin system

Antecedentes: la diabetes mellitus es una enfermedad metabólica cuyo tratamiento se basa en el uso de agentes hipoglicemiantes orales o insulina. Una opción al tratamiento son las plantas medicinales y en ese sentido, estudios previos en animales con hojas de Prosopis ruscifolia (Pr) han demostrado efecto hipoglicemiante. Objetivo: en este trabajo se reporta el efecto de P. rusciofolia (Pr) en la secreción de insulina e incretina, en ratas hiperglicémicas por aloxano. Metodología: se emplearon cuatro grupos de ratas Wistar (n=10). Dos grupos con glicemia normal que fueron tratadas con agua Pr (75 mg/Kg, per os, p.o.) y dos grupos con hiperglicemia inducida por la inyección intraperitoneal de aloxano recibieron agua Pr (75 mg/Kg, per os, p.o.) durante dos semanas. Se midieron la tolerancia oral a la glucosa, y los niveles de incretina e insulina al final del periodo de experimentación. Resultados: se encontró que el extracto promueve una mayor tolerancia a la sobrecarga de glucosa, y además un incremento significativo (p<0.001) de los niveles de incretina e insulina en sangre, comparados al grupo de ratas hiperglicémicas. Conclusión: se concluye que e l estracto etanólico de las hojas de P. ruscifolia tienen efecto hipoglicemiante en animales hiperglicémicos por un mecanismo que incluye al sistema incretina-insulina
Descritores: Hiperglicemia
-Fenômenos Bioquímicos
Incretinas
Insulina
Limites: Humanos
Tipo de Publ: Artigo Clássico
Responsável: CO56.3 - Biblioteca


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Id: biblio-1360521
Autor: Mota Júnior, Rômulo José; Oliveira, Renata Aparecida Rodrigues; Lima, Luciana Moreira; Franceschini, Sylvia do Carmo Castro; Marins, João Carlos Bouzas.
Título: Número de passos diário e sua associação com fatores de risco cardiometabólicos em professores / Daily steps and their association with cardiometabolic risk factors in teachers
Fonte: J. Phys. Educ. (Maringá);32:e3276, 2021. tab, graf.
Idioma: pt.
Resumo: RESUMO As DCV são as principais causas de morbimortalidade mundial, sendo o sedentarismo um dos principais fatores de risco para seu desenvolvimento. Assim, esta investigação teve como objetivo avaliar o número de passos diários e sua associação com fatores de risco cardiometabólicos (FRCV) em professores. Foram avaliados o número de passos diários, parâmetros antropométricos, hemodinâmicos e bioquímicos de 150 professores, divididos em Dois grupos (G1 < 10000 passos e G2 ≥ 10000 passos). Para determinar a associação e magnitude desta entre FRCV e níveis insuficientes de atividade física foram utilizados o teste qui quadrado e razão de chances. Correlação de Pearson foi utilizada para verificar a relação entre o número de passos e as demais variáveis e curvas ROC para avaliar o ponto de corte de passos diários em relação a cada FRCV. Entre os docentes avaliados, 42% eram ativos fisicamente, apresentando melhor perfil antropométrico, hemodinâmico e bioquímico. Hipertensão arterial e dislipidemias foram os FRCV que apresentaram associação com a condição de baixo número de passos. O ponto de corte de número de passos indicou valores superiores a 12,500 passos/dia para proteção contra os FRCV. Assim, a maioria dos docentes era insuficientemente ativa, destacando que aqueles que atingiram 10000 passos por dia de média, apresentaram um melhor perfil cardiometabólico.

ABSTRACT Cardiovascular diseases are the main causes of worldwide morbidity and mortality, with a sedentary lifestyle being one of the main risk factors for its development. Thus, this investigation aimed to evaluate the number of daily steps and their association with cardiometabolic risk factors (CRF) in teachers. The number of daily steps, anthropometric, hemodynamic and biochemical parameters of 150 teachers were evaluated, divided into two groups (G1 <10,000 steps and G2 ≥ 10,000 steps). To determine the association and magnitude of this between CRF and insufficient levels of physical activity, the chi square test and odds ratio were used. Pearson's correlation was used to verify the relationship between the number of steps and the other variables and ROC curves to assess the cutoff point of daily steps in relation to each CRF. Among the teachers evaluated, 42% were physically active, with a better anthropometric, hemodynamic and biochemical profile. Arterial hypertension and dyslipidemia were the CRF that were associated with the condition of low number of steps. The cut-off point for the number of steps indicated values greater than 12,500 steps/day for protection against CRF. Thus, most teachers were insufficiently active, highlighting that those who reached 10,000 steps per day on average, had a better cardiometabolic profile.
Descritores: Professores Escolares
Fatores de Risco Cardiometabólico
Atividade Motora
-Fenômenos Bioquímicos
Antropometria
Dislipidemias
Comportamento Sedentário
Hipertensão
Obesidade
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Estudo Observacional
Responsável: BR513.1 - Biblioteca Central


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Id: lil-423835
Autor: Mirakabadi, A. Z; Jalali, A; Jahromi, A. E; Vatanpur, H; Akbary, A.
Título: Biochemical changes and manifestations of envenomation produced by Odonthobuthus doriae venom in rabbits
Fonte: J. venom. anim. toxins incl. trop. dis;12(1):67-77, 2006. tab, ilus.
Idioma: en.
Resumo: Many toxins from scorpion venoms cause neurotransmitters release by activating the autonomic system. The aim of the present work was to determine osmotic fragility of red blood cells (RBCs) and serum biochemical changes produced by the venom of Odonthobuthus doriae (O. doriae), a dangerous species of scorpion in Iran. For this study we selected 2 groups, each one containing 10 New Zealand white rabbits weighing 2 ± 0.2 kg. In vivo and in vitro osmotic fragilities as well as packed cell volume (PCV) were determined. Serum was separated and used for determination of glucose, blood urea nitrogen (BUN), creatinine, uric acid (UA), triglycerides, cholesterol, aspartate aminotransferase (AST, EC 2.6.1.1), and alanine aminotransferase (ALT, EC 2.6.1.2). Results indicate that Odonthobuthus doriae venom (0.5 mg/kg, IV) causes a significant increase (p<0.05) of serum glucose, UA, PCV, ALT, and AST. Increase was also observed in BUN, but it was not statistically significant. On the other hand a significant decrease (p<0.05) was observed in triglycerides and cholesterol levels. Increased in vivo osmotic fragility of RBCs was significant too, but in vitro osmotic fragility did not show a significant change. These results support the hypothesis that the biochemical variation caused by scorpion venom can be due to an autonomic storm and release of catecholamines.(AU)
Descritores: Venenos de Escorpião/análise
Fenômenos Bioquímicos
Nitrogênio da Ureia Sanguínea
Técnicas In Vitro
Glucose
-Fragilidade Osmótica
Envenenamento
Limites: Animais
Coelhos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-461651
Autor: Zeni, A. L. B; Becker, A; Krug, M; Albuquerque, C. A. C.
Título: Histological and biochemical effects induced by sublethal doses of Bothrops jararacussu venom in mice
Fonte: J. venom. anim. toxins incl. trop. dis;13(3):664-676, 2007. ilus, graf.
Idioma: en.
Resumo: Snake venom is characterized by hemorrhagic, coagulant, proteolytic and myotoxic activities which in Bothrops jaracussu venom are related to intraspecific variations. In the present study, female Swiss mice were divided into two groups: treated with 25æg or 50æg venom. These were subdivided into three groups of six animals each, according to blood collection: 2, 4 or 24h after venom injection. Animals were anesthetized using diethyl-ether inhalation and 1ml of blood was collected by heart puncture. Then, the following organs were removed: spleen, skeletal muscle, kidneys, liver and lungs; histological sections were obtained and stained with hematoxylin-eosin (HE). The following biochemical parameters were analyzed: aspartate aminotransferase (AST/GOT), alanine aminotransferase (ALT/GPT), total lactate dehydrogenase (LDH), glucose, creatinine and urea levels, and total protein content. Results showed significant alterations in AST, LDH, glucose and urea levels, and total protein content, as well as important tissue alterations in the liver, kidneys and lungs. It could be concluded that, even using sublethal doses of venom, there were significant changes in almost all the tested biochemical parameters as well as tissue alterations in the kidneys and lungs.(AU)
Descritores: Venenos de Serpentes
Fenômenos Bioquímicos
Técnicas Histológicas
Bothrops
Limites: Animais
Camundongos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-508232
Autor: Liu, Z. H; Qian, W; Li, J; Zhang, Y; Liang, S.
Título: Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis
Fonte: J. venom. anim. toxins incl. trop. dis;15(1):79-92, 2009. ilus, graf.
Idioma: en.
Projeto: China. National Science Foundation.
Resumo: The wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed that the venom peptides are highly diverse and may be divided into three groups characterized by three independent molecular ranges: 2,000 to 2,500 Da, 4,800 to 5,500 Da and 7,000 to 8,000 Da, respectively. This molecular distribution differs substantially from those of most spider venoms studied so far. This wolf spider venom has low neurotoxic action on mice, but it can induce hemolysis of human erythrocytes. Furthermore, the venom shows antimicrobial activity against prokaryotic and eukaryotic cells.(AU)
Descritores: Venenos de Aranha/farmacologia
Fenômenos Bioquímicos
Células Eucarióticas
Hemólise
-Anti-Infecciosos
Limites: Animais
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-623508
Autor: Yap, M. K. K; Tan, N. H; Fung, S. Y.
Título: Biochemical and toxinological characterization of Naja sumatrana (Equatorial spitting cobra) venom
Fonte: J. venom. anim. toxins incl. trop. dis;17(4):451-459, 2011. tab, ilus.
Idioma: en.
Projeto: Government of Malaysia.
Resumo: The lethal and enzymatic activities of venom from Naja sumatrana (Equatorial spitting cobra) were determined and compared to venoms from three other Southeast Asian cobras (Naja sputatrix, Naja siamensis and Naja kaouthia). All four venoms exhibited the common characteristic enzymatic activities of Asiatic cobra venoms: low protease, phosphodiesterase, alkaline phosphomonoesterase and L-amino acid oxidase activities, moderately high acetylcholinesterase and hyaluronidase activities and high phospholipase A2. Fractionation of N. sumatrana venom by Resource® S cation exchange chromatography (GE Healthcare, USA) yielded nine major protein peaks, with all except the acidic protein peak being lethal to mice. Most of the protein peaks exhibit enzymatic activities, and L-amino acid oxidase, alkaline phosphomonoesterase, acetylcholinesterase, 5'-nucleotidase and hyaluronidase exist in multiple forms. Comparison of the Resource® S chromatograms of the four cobra venoms clearly indicates that the protein composition of N. sumatrana venom is distinct from venoms of the other two spitting cobras, N. sputatrix (Javan spitting cobra) and N. siamensis (Indochinese spitting cobra). The results support the revised systematics of the Asiatic cobra based on multivariate analysis of morphological characters. The three spitting cobra venoms exhibit two common features: the presence of basic, potentially pharmacologically active phospholipases A2 and a high content of polypeptide cardiotoxin, suggesting that the pathophysiological actions of the three spitting cobra venoms may be similar.(AU)
Descritores: Fenômenos Bioquímicos
Cromatografia
Venenos Elapídicos
Cardiotoxinas
Elapidae
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-1358949
Autor: Radi Isola, Rafael Alberto.
Título: Bioquímica del cartílago / Cartilage biochemistry
Fonte: In: Gramón Bagó (Uruguay). Departamento Médico. Artrosis y degeneración del cartílago articular: mecanismo de acción del condroitín sulfato y la glucosamina en la protección y reparación del cartílago. [Montevideo], Gramón Bagó de Uruguay, c2009. p.5-11, ilus.
Idioma: es.
Descritores: Cartilagem Articular
-Fenômenos Bioquímicos
Limites: Humanos
Responsável: UY1.1 - BINAME - Biblioteca Nacional de Medicina
UY1.1; 18K, ART


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Id: biblio-1352745
Autor: Spivacow, Francisco Rodolfo; del Valle, Elisa Elena; Martínez, Roxana.
Título: Riñón en esponja y litiasis renal / Sponge kidney and renal lithiasis
Fonte: Rev. nefrol. diál. traspl;39(2):108-114, jun. 2019. tabl..
Idioma: es.
Resumo: Introducción: El riñón en esponja es una malformación renal, de los túbulos colectores, que se suele asociar a nefrocalcinosis o acidosis tubular distal. La asociación con la litiasis renal se observa entre un 4-20%. Objetivo: El objetivo de nuestro trabajo fue describir factores de riesgo bioquímicos para litiasis renales, en pacientes con riñón en esponja. Material y métodos: Se realizó un estudio retrospectivo, observacional de corte, entre los años 2000 y 2017 en donde se estudiaron 37 pacientes con riñón en esponja y litiasis renal (26 mujeres y 11 hombres) de 37.3 ± 13.2 años. El diagnóstico de riñón en esponja se hizo mediante urograma excretor. Resultados: Fue observada nefrocalcinosis en el 95%. El diagnóstico bioquímico más frecuente fue la hipercalciuria idiopática que como única y asociada alteración se observó en el 59.4%. La hiperuricosuria fue el segundo diagnóstico encontrado en el 32.4% (única y asociada) seguido por la, hipocitraturia, hipomagnesuria y el pHu persistentemente ácido. En los hombres llamó la atención que un 46.2% no presentaron alteración bioquímica. Conclusiones: En conclusión se destaca la asociación relativamente frecuente de riñón en esponja y litiasis renal. La hipercalciuria idiopática fue la alteración metabólica más frecuente como causa de litogénesis, seguida por la hiperuricosuria, similar a lo descripto en la literatura, aunque en menor proporción. Otras alteraciones, como la hipocitraturia, hipomagnesuria y pHu persistentemente ácido también deben ser consideradas en el estudio de estos pacientes.

Introduction: Sponge kidney is a renal malformation of the collecting tubules, which is usually associated with nephrocalcinosis or distal tubular acidosis. The association with renal lithiasis is observed between 4-20%. Objective: The aim of our work was to describe the biochemical risk factors of renal lithiasis in patients with sponge kidney. Methods: A retrospective, observational, cross-sectional study was conducted between 2000 and 2017, in which 37 patients with sponge kidney and renal lithiasis (26 women and 11 men), aged 37.3 ± 13.2 years, were studied. The diagnosis of sponge kidney was made by excretory urography. Results: Nephrocalcinosis was observed in 95% of patients. The most frequent biochemical diagnosis was idiopathic hypercalciuria, which was observed, as a single and associated alteration, in 59.4% of cases. Hyperuricosuria was the second diagnosis found in 32.4% (single and associated) followed by hypocitraturia, hypomagnesuria and persistently acid pHu. Surprisingly, 46.2% of men presented no biochemical alteration. Conclusions: Our findings highlight the relatively frequent association of sponge kidney and renal lithiasis. Idiopathic hypercalciuria was the most common metabolic alteration as the cause of lithogenesis, followed by hyperuricosuria, similar to that described in the literature, but to a lesser extent. Other alterations, such as hypocitraturia, hypomagnesuria and persistently acid pHu, should also be considered in the study of these patients.
Descritores: Nefrolitíase/complicações
Nefrolitíase/etiologia
-Fenômenos Bioquímicos
Distúrbios do Metabolismo do Cálcio
Hipercalciúria/diagnóstico
Nefrocalcinose/diagnóstico
Limites: Humanos
Tipo de Publ: Artigo Clássico
Responsável: AR444.1 - BAN - Biblioteca Argentina de Nefrología Dr. Víctor R. Miatello



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