Base de dados : LILACS
Pesquisa : G02.111.570 [Categoria DeCS]
Referências encontradas : 117 [refinar]
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Texto completo SciELO Brasil
Azevedo, Joäo L
Texto completo
Id: biblio-974284
Autor: Elias, Luciana M; Fortkamp, Diana; Sartori, Sérgio B; Ferreira, Marília C; Gomes, Luiz H; Azevedo, João L; Montoya, Quimi V; Rodrigues, André; Ferreira, Antonio G; Lira, Simone P.
Título: The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose
Fonte: Braz. j. microbiol;49(4):840-847, Oct.-Dec. 2018. graf.
Idioma: en.
Projeto: FAPESP; . CNPq.
Resumo: ABSTRACT Anthracnose is a crop disease usually caused by fungi in the genus Colletotrichum or Gloeosporium. These are considered one of the main pathogens, causing significant economic losses, such as in peppers and guarana. The current forms of control include the use of resistant cultivars, sanitary pruning and fungicides. However, even with the use of some methods of controlling these cultures, the crops are not free of anthracnose. Additionally, excessive application of fungicides increases the resistance of pathogens to agrochemicals and cause harm to human health and the environment. In order to find natural antifungal agents against guarana anthracnose, endophytic fungi were isolated from Amazon guarana. The compounds piliformic acid and cytochalasin D were isolated by chromatographic techniques from two Xylaria spp., guided by assays with Colletotrichum gloeosporioides. The isolated compounds were identified by spectrometric techniques, as NMR and mass spectrometry. This is the first report that piliformic acid and cytochalasin D have antifungal activity against C. gloeosporioides with MIC 2.92 and 2.46 µmol mL-1 respectively. Captan and difenoconazole were included as positive controls (MIC 16.63 and 0.02 µmol mL-1, respectively). Thus, Xylaria species presented a biotechnological potential and production of different active compounds which might be promising against anthracnose disease.
Descritores: Doenças das Plantas/prevenção & controle
Fungicidas Industriais/farmacologia
Doenças das Plantas/microbiologia
Espectrometria de Massas
Xylariales/isolamento & purificação
Estrutura Molecular
Colletotrichum/efeitos dos fármacos
Endófitos/isolamento & purificação
Fungicidas Industriais/isolamento & purificação
Fungicidas Industriais/química
Responsável: BR1.1 - BIREME

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Texto completo SciELO Brasil
Texto completo
Id: lil-623974
Autor: Zhou, Bing-Nan.
Título: Some progress on the chemistry of natural bioactive terpenoids form Chinese medicinal plants
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):219-226, 1991. ilus, graf.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: (1) Pseudolaric acids - Novel diterpenes, Pseudolaric acid A, B, C and D were isolated from Pseudolarix kaempferi Gorden (pinaceae). Their structures were assigned by spectroscopic data and chemical correlations. In the contineous studies, the absolute configurations, the conformations in the solutions, the framentation mechanisms of MS and assigments of all NMR spectral signals were also reported. They showed the antifungal and cytotoxic activities. (2) Daphnane diterpenes - In the further studies on the plants of Thymelaeaceae, besides 10 known diterpenes, 16 new daphnane diterpenes were isolated from Daphne genkwa, D. tangutica, D. giraldii, Wikstroemie chamaedaphne. They showed the antifertilities activities. (3) Tripterygium diterpenes 14 new diterpenes were isolated from Triperygium wilfordii, T. regeli and T. hypoglaucum. Some of them showed the antitumor activities. The CD spectra showed that A/B ring of all compoundshave trans configuration as same as tripdiolide and triptolide determined by X-ray diffraction (4) Pregnane glycosides from Marsdenia koi - Two new pregnane glycosides marsdenikoiside A and marsdenikoiside B which can terminate the early pregnancy were isolated from Marsdeia koi. Their structures were elucidated by hydrolysis and spectroscopic methods.
Descritores: Relação Estrutura-Atividade
Medicamentos de Ervas Chinesas/química
Anticoncepcionais/isolamento & purificação
Anticoncepcionais/uso terapêutico
Diterpenos/isolamento & purificação
-Espectroscopia de Ressonância Magnética
Estrutura Molecular
Conformação Molecular
Limites: Humanos
Responsável: BR1.1 - BIREME

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Texto completo SciELO Brasil
Lorenzetti, B. B
Texto completo
Id: lil-623955
Autor: Oliveira, A. B de; Silva, T. H. A; Ferreira, S. H; Lorenzetti, B. B.
Título: Quaternary ammonium salt derivatives of allylphenols with peripheral analgesic effect
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):133-136, 1991. ilus, tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Ammonium salt derivatives of natural allylphenols were synthesized with the purpose of obtaining potential peripheral analgesics. These drugs, by virtue of their physicochemical properties, would not be able to cross the blood brain barrier. Their inability to enter into the central nervous system (CNS) should prevent several adverse effects observed with classical opiate analgesics (Ferreira et al., 1984). Eugenol (1) O-methyleugenol (5) and safrole (9) were submitted to nitration, reduction and permethylation, leading to the ammonium salts 4, 8 and 12. Another strategy applied to eugenol (1), consisting in its conversion to a glycidic ether (13), opening the epoxide ring with secondary amines and methylation, led to the ammonium salts 16 and 17. All these ammonium salts showed significant peripheral analgesic action, in modified version of the Randall-Sellito test (Ferreira et al. 1978), at non-lethal doses. The ammonium salt 8 showed an activity comparable to that of methylnalorphinium, the prototype of an ideal peripheral analgesic (Ferreira et al., 1984).
Descritores: Safrol/síntese química
Eugenol/análogos & derivados
Eugenol/síntese química
Compostos de Amônio/síntese química
Compostos de Amônio Quaternário/síntese química
Compostos de Amônio Quaternário/farmacologia
Analgésicos/síntese química
-Medição da Dor
Estrutura Molecular
Ratos Wistar
Limites: Animais
Responsável: BR1.1 - BIREME

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Texto completo SciELO Brasil
Texto completo
Id: biblio-889127
Autor: Jiang, Cheng; Song, Jinzhu; Zhang, Junzheng; Yang, Qian.
Título: New production process of the antifungal chaetoglobosin A using cornstalks
Fonte: Braz. j. microbiol;48(3):410-418, July-Sept. 2017. tab, graf.
Idioma: en.
Projeto: National High Technology Research and Development Program; . \"Twelfth Five-Year Plan\" National Science and Technology Program on Rural Area.
Resumo: Abstract Chaetoglobosin A is an antibacterial compound produced by Chaetomium globosum, with potential application as a biopesticide and cancer treatment drug. The aim of this study was to evaluate the feasibility of utilizing cornstalks to produce chaetoglobosin A by C. globosum W7 in solid-batch fermentation and to determine an optimal method for purification of the products. The output of chaetoglobosin A from the cornstalks was 0.34 mg/g, and its content in the crude extract was 4.80%. Purification conditions were optimized to increase the content of chaetoglobosin A in the crude extract, including the extract solvent, temperature, and pH value. The optimum process conditions were found to be acetone as the extractant, under room temperature, and at a pH value of 13. Under these conditions, a production process of the antifungal chaetoglobosin A was established, and the content reached 19.17%. Through further verification, cornstalks could replace crops for the production of chaetoglobosin A using this new production process. Moreover, the purified products showed great inhibition against Rhizoctonia solani, with chaetoglobosin A confirmed as the main effective constituent (IC50 = 3.88 µg/mL). Collectively, these results demonstrate the feasibility of using cornstalks to synthesize chaetoglobosin A and that the production process established in this study was effective.
Descritores: Microbiologia Industrial/métodos
Alcaloides Indólicos/metabolismo
Microbiologia Industrial/instrumentação
Estrutura Molecular
Caules de Planta/metabolismo
Caules de Planta/microbiologia
Alcaloides Indólicos/isolamento & purificação
Alcaloides Indólicos/química
Antifúngicos/isolamento & purificação
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME

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Texto completo SciELO Brasil
Texto completo
Id: biblio-889085
Autor: Teng, Feixiang; Sun, Jinxia; Yu, Lili; Li, Qisong; Cui, Yubao.
Título: Homology modeling and epitope prediction of Der f 33
Fonte: Braz. j. med. biol. res = Rev. bras. pesqui. méd. biol;51(5):e6213, 2018. tab, graf.
Idioma: en.
Projeto: National Natural Sciences Foundation; . Key Program of Wuxi health and Family Planning Commission; . 333 project of Jiangsu Province.
Resumo: Dermatophagoides farinae (Der f), one of the main species of house dust mites, produces more than 30 allergens. A recently identified allergen belonging to the alpha-tubulin protein family, Der f 33, has not been characterized in detail. In this study, we used bioinformatics tools to construct the secondary and tertiary structures and predict the B and T cell epitopes of Der f 33. First, protein attribution, protein patterns, and physicochemical properties were predicted. Then, a reasonable tertiary structure was constructed by homology modeling. In addition, six B cell epitopes (amino acid positions 34-45, 63-67, 103-108, 224-230, 308-316, and 365-377) and four T cell epitopes (positions 178-186, 241-249, 335-343, and 402-410) were predicted. These results established a theoretical basis for further studies and eventual epitope-based vaccine design against Der f 33.
Descritores: Tubulina (Proteína)/química
Epitopos de Linfócito T/química
Epitopos de Linfócito B/química
Dermatophagoides farinae/química
Antígenos de Dermatophagoides/química
-Tubulina (Proteína)/genética
Tubulina (Proteína)/imunologia
Estrutura Molecular
Estrutura Terciária de Proteína
Mapeamento de Epitopos
Epitopos de Linfócito T/genética
Epitopos de Linfócito B/genética
Biologia Computacional
Análise de Sequência de Proteína
Dermatophagoides farinae/genética
Dermatophagoides farinae/imunologia
Antígenos de Dermatophagoides/genética
Antígenos de Dermatophagoides/imunologia
Limites: Animais
Responsável: BR1.1 - BIREME

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Texto completo SciELO Saúde Pública
Lefèvre, Fernando
Texto completo
Id: lil-733130
Autor: Caron, Eduardo; Lefèvre, Fernando; Lefèvre, Ana Maria Cavalcanti.
Título: In the final analysis, are we a consumer society or not? Implications for health / Afinal, somos ou não somos uma sociedade de consumo? Consequências para a saúde
Fonte: Ciênc. saúde coletiva;20(1):145-153, 01/2015.
Idioma: en.
Resumo: In this paper, the question of Brazil's insertion today as a country with the characteristics of modern consumer societies is discussed, focusing on the commercialization of the health sector, the segmentation of the health system and the contradictions of the rights to health care in the social context in question. Some research data on these issues broadcast in the National News Bulletins of Globo TV during the year of 2012 are presented, in which the high technology private hospital as a consumer icon, the underfunding of the public health system and the rejection of a poor and deprived Unified Health System are analyzed.

Discute-se aqui a nossa inserção como país, hoje, nas sociedades de consumo características da modernidade, enfocando a mercantilização na área da saúde, a segmentação do sistema de saúde e as contradições do direito à saúde no contexto social em questão. São apresentados dados de pesquisa sobre o tema no Jornal Nacional da Rede Globo de Televisão, durante o ano de 2012, na qual se analisa o hospital privado de alto padrão tecnológico como ícone de consumo, o subfinanciamento do sistema público de saúde e a rejeição de um Sistema Único de Saúde pobre e carente.
Descritores: Compostos Azo/análise
Cromatografia em Gel/métodos
Cromatografia Líquida de Alta Pressão/métodos
Espectrometria de Massas por Ionização por Electrospray/métodos
Espectrometria de Massas em Tandem/métodos
-Compostos Azo/química
Análise de Alimentos/métodos
Corantes de Alimentos/análise
Corantes de Alimentos/química
Estrutura Molecular
Reprodutibilidade dos Testes
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME

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Texto completo SciELO Brasil
Texto completo
Texto completo
Id: biblio-889443
Autor: Bairros, André Valle de; Pereira, Danillo Baptista; Cordeiro, Everson Willian Fialho; Paim, Clésio Soldateli; Silva, Fabiana Ernestina Barcellos da; Malesuik, Marcelo Donadel; Paula, Fávero Reisdorfer.
Título: Evaluation of the influence of fluoroquinolone chemical structure on stability: forced degradation and in silico studies
Fonte: Braz. J. Pharm. Sci. (Online);54(1):e00188, 2018. tab, graf.
Idioma: en.
Projeto: CNPq.
Resumo: ABSTRACT Fluoroquinolones are a known antibacterial class commonly used around the world. These compounds present relative stability and they may show some adverse effects according their distinct chemical structures. The chemical hydrolysis of five fluoroquinolones was studied using alkaline and photolytic degradation aiming to observe the differences in molecular reactivity. DFT/B3LYP-6.31G* was used to assist with understanding the chemical structure degradation. Gemifloxacin underwent degradation in alkaline medium. Gemifloxacin and danofloxacin showed more degradation perceptual indices in comparison with ciprofloxacin, enrofloxacin and norfloxacin in photolytic conditions. Some structural features were observed which may influence degradation, such as the presence of five member rings attached to the quinolone ring and the electrostatic positive charges, showed in maps of potential electrostatic charges. These measurements may be used in the design of effective and more stable fluoroquinolones as well as the investigation of degradation products from stress stability assays.
Descritores: Simulação por Computador/estatística & dados numéricos
Fluoroquinolonas/efeitos adversos
-Raios Ultravioleta/efeitos adversos
Estrutura Molecular
Cromatografia Líquida/métodos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas

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Costa, César
Texto completo
Id: biblio-979547
Autor: Jaramillo-Fierro, Ximena; Zambrano, César; Fernández, Francisco; Saez-Puche, Regino; Costa, Cesar; Guerrero, Víctor; González, Silvia; Salcedo-Reyes, Juan Carlos.
Título: Synthesis, characterization and theoretical calculations of Cu(I) complex of trithiocyanuric acid [Cu(ttc)3] / Síntesis, caracterización y cálculos teóricos del complejo Cu(I) de ácido cianúrico [Cu(ttc)3] / Síntese, caracterização e cálculos teóricos do complexo Cu(I) de ácido cianúrico [Cu(ttc)3]
Fonte: Univ. sci;23(2):241-266, May-Aug. 2018. tab, graf.
Idioma: en.
Resumo: Abstract A new Cu(I) complex constructed by reaction of trithiocyanuric acid (ttc) and copper(II) perchlorate hexahydrate has been successfully synthesized by a slow sedimentation method in a DMF solvent at room temperature. The molecular structure of the compound was elucidated by MALDI-TOF MS, UV-Vis and FTIR spectroscopy, DSC-TGA analysis and magnetic susceptibility measurement. The proposed structure was corroborated by a computational study carried out with the Gaussian09® and AIMAII® programs using the RB3LYP hybrid DFT functional with both 6-31G and Alhrich-TZV basis sets. The calculated vibrational frequencies values were compared with experimental FTIR values. Photophysical properties of the synthesized complex were evaluated by UV-Visible spectroscopy and compared with computed vertical excitation obtained from TDDFT. The theoretical vibrational frequencies and the UV-Vis spectra are in good agreement with the experimental values. Additionally, the Frontier Molecular Orbitals (HOMO - LUMO) and the Molecular Electrostatic Potential of the complex was calculated using same theoretical approximation. The results showed the interaction between three coordinated ligand atoms and the Cu(I) ion.

Resumen Un nuevo complejo de Cu(I) elaborado por la reacción de ácido cianúrico (ttc) y perclorato de cobre(II) hexahidrato se sintetizó exitosamente por medio de un método lento de sedimentación en un solvente de DMF a temperatura ambiente. La estructura molecular del compuesto se determinó utilizando MS de MALDI-TOF, la espectroscopia de UV-VIS y de FTIR, el análisis de DSC-TGA y el análisis magnético de susceptibilidad. La estructura propuesta se corroboró por medio de un estudio computacional usando los programas Gaussian09® y AIMAII®, utilizando el híbrido RB3LYP DFT con los equipos 6-31G y Alhrich-TZV. Se compararon los valores calculados de las frecuencias vibracionales con los valores experimentales de FTIR. Se evaluaron las características fotofísicas del complejo sintetizado usando espectroscopia UV-visible y se compararon con la vibración vertical obtenida de TDDFT. Las frecuencias teóricas vibracionales y los espectros UV-VIS coinciden con los valores experimentales. Además, se calcularon las órbitas moleculares (HOMO - LUMO) y el potencial electrostático molecular del complejo usando la misma aproximación teórica. Los resultados demostraron la interacción entre tres receptores de átomos coordinados y el ion del Cu(I).

Resumo Um novo complexo de Cu(I) elaborado pela reação de ácido cianúrico (ttc) e perclorato de cobre (II) hexahidratado foi sintetizado de maneira exitosa por meio de um método lento de sedimentação em um solvente de DMF a temperatura ambiente. A estrutura molecular do composto se determinou utilizando MALDI-TOF, espectroscopia de UV-VIS e FTIR, DSC-TGA e análise magnético de susceptibilidade. A estrutura proposta se corroborou por meio de um estudo computacional usando os programas Gaussian09® e AIMAII®, utilizando o híbrido RB3LYP DFT com os equipamentos 6-31G e Alhirich-TZV. Se compararam os valores calculados das frequências vibracionais com os valores experimentais de FTIR. Se avaliaram as características fotofísicas do complexo sintetizado utilizando espectroscopia UV-VIS e se compararam com a vibração vertical obtida de TDDFT. As frequências teóricas vibracionais e os espectros UV-VIS coincidem com os valores experimentais. Além disso, se calcularam as órbitas moleculares (HOMO - LUMO) e o potencial eletrostático molecular do complexo utilizando a mesma aproximação teórica. Os resultados demonstraram a interação entre três receptores de átomos coordenados e o íon de Cu(I).
Descritores: Estrutura Molecular
-Análise Espectral
Complexos de Coordenação
Responsável: CO185.1 - Biblioteca Alfonso Borrero Cabal, S. J.

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Id: lil-754746
Autor: Chakraborty, Indrani; Datta, Soumita; Sukul, Anirban; Chakravarty, Rathin; Sukul, Nirmal C.
Título: Variation in free and bound water molecules indifferent homeopathic potencies as revealed by their Fourier Transform Infrared Spectroscopy (FTIR)
Fonte: Int. j. high dilution res;13(49):189-196, 2014. graf, tab.
Idioma: en.
Resumo: Homeopathic potencies 12cH and above cross the Avogadro number, and as such do not containany original drug molecules in their aqueous ethanol medium. It is thought H-bonded waterstructures preserved by ethanol carry the information of initial drug molecules. Potentized drugs show some differences with respect to their infrared (IR) absorption spectra. In a water-ethanol solution, free water molecules vary according to the concentration of ethanol. In the present study the concentration of ethanol has been kept constant at 0.03 molar fractions in 6 differenthomeopathic potencies. Aim: to see whether different homeopathic potencies having fixed ethanolcontent show variation in FTIR spectra and also free water molecules. Two potencies like 8cH and32cH of three homeopathic drugs Natrum mur, Cantharis and Nux vomica were used in thestudy, and their ethanol concentration was kept fixed at 0.03 molar fraction. The control wasconsidered to be aqueous ethanol at the same concentration. Spectrum of reference water wasalso taken. Fourier transform infrared (FTIR) absorption spectra were obtained in the wavenumber region of 4000 – 2800 cm-1. The half-width at half-maximum was measured for eachspectrum. The intensity of each spectrum was normalized at 3410 cm-1 close to the peak. The difference spectrum (absorbance of drug solution – absorbance of reference water) for each drugand the control was obtained. FTIR spectra showed variation in absorbance intensity on both thehigh and low frequency side of the O-H stretching band in different drugs as well as the control. The C-H stretching band of 2977 cm-1 also showed variation in intensity in different drugs...
Descritores: Altas Potências
Cantharis vesicatoria/análise
Espectroscopia de Infravermelho com Transformada de Fourier
Natrium Muriaticum/análise
Strychnos nux-vomica/análise
-Estrutura Molecular
Responsável: BR926.1 - Biblioteca Artur de Almeida Rezende Filho

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Texto completo
Id: biblio-834790
Autor: Castro Álvarez, John Fredy; Campuzano Maya, Germán.
Título: Biología molecular en medicina: nuevas estrategias que originan nuevos desenlaces / Molecular biology at medicine: new strategies that leads to new outcomes
Fonte: Med. lab;2014, 20(1-2):11-42, 2014. ilus, graf, tab.
Idioma: es.
Resumo: El avance científico y tecnológico de la biología molecular en el mundo trajo un nuevo abordaje de los problemas biológicos, que ha permitido dar paso a una nueva etapa de la investigación científica en la biología, la química y la física, así como a nuevas prácticas en la medicina. El uso de las herramientas de la biología molecular como apoyo diagnóstico en un amplio número de enfermedades infecciosas y de base genética es uno de los campos que mayor desarrollo tiene actualmente en la medicina. Esta área de la práctica médica se circunscribe en el uso de la información genética (ADN y ARN) de los individuos para el diagnóstico y tratamiento de la enfermedad desde la patología molecular y la terapia génica, y actualmente, en el control y prevención de las mismas desde la identificación de factores de riesgo y el uso de esta información en la epidemiología molecular. Este módulo da inicio a una completa selección de temas de medicina y biología molecular que introducirán al lector en el qué, por qué y para qué de las herramientas de la biología molecular que se usan actualmente en los mejores laboratorios clínicos y de investigación en el mundo para la prevención, apoyo diagnóstico y terapéutica de un amplio número de enfermedades.

Scientific and technological development of molecular biology in the world generated a new approach in the biological problems, which have opened a new era of scientific research in biology, chemistry, and physics, as well as to new procedures in medicine. The use of molecular biology tools in diagnosis of a wide range of infectious and genetic diseases is currently the base that supports the medical practice. This area of medicine is related with the genetic information use (DNA and RNA), of the subjects for diagnosis and treatment of the disease since molecular pathology and gene therapy, and the control and prevention of disease with the risk factors identification and the use of this information in the molecular epidemiology. This article is the beginning to a reviews series of molecular biology and medicine, that will introduce the reader in the what, why and how of the molecular biology tools currently used in clinical and research laboratories in the world for the prevention, diagnosis, and therapeutic support of a wide number of diseases.
Descritores: DNA
Biologia Molecular
Estrutura Molecular
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CO373.9 - EDIMECO - Editora Médica Colombiana S.A.

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