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Id: lil-636825
Autor: Peñaranda-Parada, Édgar; Spinel-Bejarano, Néstor; Restrepo, José Félix; Rondón-Herrera, Federico; Millán, Alberto; Iglesias Gamarra, Antonio.
Título: Enfermedades Autoinflamatorias / Autoinflammatory Diseases
Fonte: Rev. colomb. reumatol;17(2):86-95, Apr.-June 2010. ilus, tab.
Idioma: es.
Resumo: Presentamos un artículo de revisión sobre las enfermedades autoinflamatorias, narrando su origen histórico y describiendo la estructura proteica y molecular del Inflamosoma, la clasificación actual de los trastornos autoinflamatorios y una descripción de las características inmunogenéticas y clínicas más sobresalientes de cada enfermedad.

We present a review article on the autoinflammatory diseases, narrating its historical origin and describing the protein and molecular structure of the Inflammasome, the current classification of the autoinflammatory diseases and a description of the immunogenetics and clinical characteristics more important of every disease.
Descritores: Estrutura Molecular
Elementos Estruturais de Proteínas
-Classificação
Doenças Hereditárias Autoinflamatórias
Síndromes Periódicas Associadas à Criopirina
Inflamassomos
Imunogenética
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CO356.9


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Id: biblio-1093292
Autor: Fernández Martínez, Lesbia; Garrote Santana, Heidys; Díaz Alonso, Carmen Alina.
Título: Biomarcadores en las neoplasias mieloproliferativas clásicas BCR-ABL1 negativas / Biomarkers in Classical Myeloproliferative Neoplasms BCR-ABL1 negative
Fonte: Rev. cuba. hematol. inmunol. hemoter;35(4):e1029, oct.-dic. 2019. graf.
Idioma: es.
Resumo: Introducción: Los biomarcadores son útiles en la definición del diagnóstico, pronóstico y seguimiento de múltiples enfermedades. La detección o medición de uno o más biomarcadores específicos representan alteraciones en vías genéticas o epigenéticas que controlan la proliferación, diferenciación o muerte celular. Las neoplasias mieloproliferativas constituyen un grupo fenotípicamente diverso de hemopatías malignas de origen clonal, caracterizadas por una sobreproducción simple o multilineal de los elementos eritroides, mieloides y megacariocíticos; así como de una marcada predisposición a la trombosis, sangramiento y transformación leucémica. Dentro de ellas se incluyen: la policitemia vera, la trombocitemia esencial y la mielofibrosis primaria, conocidas como neoplasias mieloproliferativas clásicas BCR-ABL1 (o cromosoma Philadelfia) negativas. Las mutaciones somáticas en genes como JAK2, MPL y CARL se comportan como mutaciones drivers iniciadoras, responsables del fenotipo mieloproliferativo. Métodos: Se revisaron artículos relacionados publicados en los últimos años, en algunas bases de datos de la Biblioteca Virtual de Salud. En esta revisión se exponen los mecanismos moleculares generales de esas mutaciones y su expresión clínica; se hace referencia a las neoplasias mieloproliferativas triple negativas y sus implicaciones clínicas y se indica el algoritmo diagnóstico propuesto por la Organización Mundial de la Salud que incluye los nuevos biomarcadores. Conclusiones: El estudio molecular proporciona información valiosa para el diagnóstico y seguimiento de las neoplasias mieloprolifrativas, pero no logra diferenciar entre cada una de ellas. Por esto, se requiere de la adecuada aplicación del método clínico para llegar a un diagnóstico certero con ayuda de otros exámenes complementarios(AU)

Introduction: Biomarkers are useful in the definition of diagnosis, prognosis and monitoring of multiple diseases. The detection or measurement of one or more specific biomarkers represents alterations in genetic or epigenetic pathways that control proliferation, differentiation or cell death. The myeloproliferative neoplasms constitute a phenotypically diverse group of malignant hemopathies of clonal origin, characterized by a simple or multilinear overproduction of the erythroid, myeloid and megakaryocytic elements; as well as a marked predisposition to thrombosis, bleeding and leukemic transformation. These include: polycythemia vera, essential thrombocythemia, and primary myelofibrosis, known as classical negative myeloproliferative neoplasms BCR-ABL1 (or Philadelphia chromosome). Somatic mutations in genes such as JAK2, MPL and CARL behave as initiating driver mutations responsible for the myeloproliferative phenotype. Methods: Articles published in the last years were reviewed in some databases of the Virtual Health Library (VHL). In this review we expose the general molecular mechanisms of these mutations and their clinical expression; reference is made to the triple negative myeloproliferative neoplasms and their clinical implications and the diagnostic algorithm proposed by the World Health Organization that includes the new biomarkers is indicated. Conclusions: The molecular study provides valuable information for the diagnosis and monitoring of myeloproliferative neoplasms, but fails to differentiate between each of them. Therefore, the appropriate application of the clinical method is required to arrive at an accurate diagnosis with the help of other complementary tests(AU)
Descritores: Biomarcadores Tumorais/genética
Doenças Mieloproliferativas-Mielodisplásicas/diagnóstico
-Algoritmos
Estrutura Molecular
Diagnóstico Clínico/diagnóstico
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: biblio-886616
Autor: ALMEIDA, MACIA C S DE; SOUZA, LUCIANA G S; FERREIRA, DANIELE A; PINTO, FRANCISCO C L; OLIVEIRA, DÉBORA R DE; SANTIAGO, GILVANDETE M P; MONTE, FRANCISCO J Q; BRAZ-FILHO, RAIMUNDO; LEMOS, TELMA L G DE.
Título: 7-epi-griffonilide, a new lactone from Bauhinia pentandra: complete 1H and 13C chemical shift assignments
Fonte: An. acad. bras. ciênc;89(1):65-71, Jan,-Mar. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT A new lactone, 7-epi-griffonilide (1), and six known compounds, 2, 3a - 3c, 4a and 4b, were isolated from the leaves of Bauhinia pentandra (Fabaceae). The structures elucidation of 1 and 2 were based on detailed 2D NMR techniques and spectral comparison with related compounds, leading to complete assignment of the 1H and 13C NMR spectra.
Descritores: Folhas de Planta/química
Bauhinia/química
Lactonas/isolamento & purificação
Lactonas/química
-Valores de Referência
Estereoisomerismo
Estrutura Molecular
Espectroscopia de Ressonância Magnética Nuclear de Carbono-13/métodos
Espectroscopia de Prótons por Ressonância Magnética/métodos
Responsável: BR1.1 - BIREME


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Id: biblio-886635
Autor: SHI, CHEN-SHAN; SANG, YA-XIN; SUN, GUI-QING; LI, TIAN-YE; GONG, ZHENG-SI; WANG, XIANG-HONG.
Título: Characterization and bioactivities of a novel polysaccharide obtained from Gracilariopsis lemaneiformis
Fonte: An. acad. bras. ciênc;89(1):175-189, Jan,-Mar. 2017. graf.
Idioma: en.
Resumo: ABSTRACT Gracilariopsis lemaneiformis is a type of red alga that contains seaweed polysaccharide agar. In this study, a novel non-agar seaweed polysaccharide fraction named GCP (short of crude polysaccharide obtained from Gracilariopsis lemaneiformis) was isolated from Gracilariopsis lemaneiformis. Structural analysis showed that GCP shows triple helical chain conformation when dissolved in water and has many branches and long side chains. Also, 1→3 linkage is the major linkage and the sugar structures are galactopyranose configurations linked by β-type glycosidic linkages. Two macromolecular substance fractions (GCP-1 and GCP-2) were purified by DEAE Sepharose Fast Flow column chromatography. Moreover, a splenocyte damage assay and splenocyte proliferation assay were used to analyse the bioactivities of GCP, GCP-1 and GCP-2. It was demonstrated that polysaccharides could protect splenocyte damaged by H2O2; GCP-2 shows a greatest protection rate, that is, 92.8%, which significantly enhanced the splenocyte proliferation, and GCP showed the highest proliferation rate, 9.30%. The results suggested that this type of novel non-agar polysaccharide displayed remarkable antioxidant and immunomodulatory activities and early alkali treatment could decrease the activities. It may represent a potential material for health food and clinical medicines.
Descritores: Polissacarídeos/química
Alga Marinha/química
Rodófitas/química
-Polissacarídeos/isolamento & purificação
Valores de Referência
Ensaio de Imunoadsorção Enzimática
Linfócitos/efeitos dos fármacos
Microscopia Eletrônica de Varredura
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Cromatografia Líquida de Alta Pressão
Espectroscopia de Infravermelho com Transformada de Fourier
Ácido Periódico/química
Proliferação de Células/efeitos dos fármacos
Peso Molecular
Limites: Animais
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-886693
Autor: OLIVEIRA, DÉBORA R DE; NEPOMUCENO, DELCI D; CASTRO, ROSANE N; BRAZ FILHO, RAIMUNDO; CARVALHO, MÁRIO G DE.
Título: Special metabolites isolated from Urochloa humidicola (Poaceae)
Fonte: An. acad. bras. ciênc;89(2):789-797, Apr.-June 2017. graf.
Idioma: en.
Resumo: ABSTRACT This study aims to identify special metabolites in polar extracts from Urochloa humidicola (synonym Brachiaria humidicola) that have allelopathic effects and induce secondary photosensitization in ruminants. The compounds were isolated and identified via chromatographic and spectroscopic techniques. The compounds 4-hydroxy-3-methoxy-benzoic acid, trans-4-hydroxycinnamic acid, and p-hydroxy-benzoic acid; the flavonols isorhamnetin-3-O-β-d-glucopyranoside and methyl quercetin-3-O-β-d-glucuronate; and kaempferitrin, quercetin-3-O-α-l-rhamnopyranoside, and tricin were identified in the extract from the leaves of Urochloa humidicola. Two furostanic saponins, namely, dioscin and 3-O-α-l-rhamnopyranosyl-(1-4)-[α-l-rhamnopyranosyl-(1-2)]-β-d-glucopyranosyl-penogenin, as well as catechin-7-O-β-d-glucopyranoside were identified in the methanolic extract obtained from the roots of this plant. This species features a range of metabolites that may be toxic for animals if used in food and may interfere with the growth medium, thereby inhibiting the development of other species.
Descritores: Flavonoides/isolamento & purificação
Extratos Vegetais/química
Brachiaria/química
-Parabenos/isolamento & purificação
Parabenos/química
Saponinas/química
Ácido Vanílico/química
Flavonoides/química
Crotonatos/isolamento & purificação
Crotonatos/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Cromatografia em Camada Delgada
Glicosídeos/isolamento & purificação
Glicosídeos/química
Responsável: BR1.1 - BIREME


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Id: biblio-886744
Autor: OLIVEIRA, SIMONE S S; BELLO, MURILO L; RODRIGUES, CARLOS R; AZEVEDO, PAULA L DE; RAMOS, MARIA C K V; AQUINO-NETO, FRANCISCO R DE; FIAUX, SORELE B; DIAS, LUIZA R S.
Título: Asymmetric bioreduction of ketoesters derivatives by Kluyveromyces marxianus: influence of molecular structure on the conversion and enantiomeric excess
Fonte: An. acad. bras. ciênc;89(3):1403-1415, July-Sept. 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT This study presents the bioreduction of six β-ketoesters by whole cells of Kluyveromyces marxianus and molecular investigation of a series of 13 β-ketoesters by hologram quantitative structure-activity relationship (HQSAR) in order to relate with conversion and enantiomeric excess of β-stereogenic-hydroxyesters obtained by the same methodology. Four of these were obtained as (R)-configuration and two (S)-configuration, among them four compounds exhibited >99% enantiomeric excess. The β-ketoesters series LUMO maps showed that the β-carbon of the ketoester scaffold are exposed to undergo nucleophilic attack, suggesting a more favorable β-carbon side to enzymatic reduction based on adopted molecular conformation at the reaction moment. The HQSAR method was performed on the β-ketoesters derivatives separating them into those provided predominantly (R)- or (S)-β-hydroxyesters. The HQSAR models for both (R)- and (S)-configuration showed high predictive capacity. The HQSAR contribution maps suggest the importance of β-ketoesters scaffold as well as the substituents attached therein to asymmetric reduction, showing a possible influence of the ester group carbonyl position on the molecular conformation in the enzyme catalytic site, exposing a β-carbon side to the bioconversion to (S)- and (R)-enantiomers.
Descritores: Kluyveromyces/metabolismo
Ésteres/química
Cetonas/química
-Oxirredução
Biotransformação
Estrutura Molecular
Responsável: BR1.1 - BIREME


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Azevedo, Joäo L
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Id: biblio-974284
Autor: Elias, Luciana M; Fortkamp, Diana; Sartori, Sérgio B; Ferreira, Marília C; Gomes, Luiz H; Azevedo, João L; Montoya, Quimi V; Rodrigues, André; Ferreira, Antonio G; Lira, Simone P.
Título: The potential of compounds isolated from Xylaria spp. as antifungal agents against anthracnose
Fonte: Braz. j. microbiol;49(4):840-847, Oct.-Dec. 2018. graf.
Idioma: en.
Projeto: FAPESP; . CNPq.
Resumo: ABSTRACT Anthracnose is a crop disease usually caused by fungi in the genus Colletotrichum or Gloeosporium. These are considered one of the main pathogens, causing significant economic losses, such as in peppers and guarana. The current forms of control include the use of resistant cultivars, sanitary pruning and fungicides. However, even with the use of some methods of controlling these cultures, the crops are not free of anthracnose. Additionally, excessive application of fungicides increases the resistance of pathogens to agrochemicals and cause harm to human health and the environment. In order to find natural antifungal agents against guarana anthracnose, endophytic fungi were isolated from Amazon guarana. The compounds piliformic acid and cytochalasin D were isolated by chromatographic techniques from two Xylaria spp., guided by assays with Colletotrichum gloeosporioides. The isolated compounds were identified by spectrometric techniques, as NMR and mass spectrometry. This is the first report that piliformic acid and cytochalasin D have antifungal activity against C. gloeosporioides with MIC 2.92 and 2.46 µmol mL-1 respectively. Captan and difenoconazole were included as positive controls (MIC 16.63 and 0.02 µmol mL-1, respectively). Thus, Xylaria species presented a biotechnological potential and production of different active compounds which might be promising against anthracnose disease.
Descritores: Doenças das Plantas/prevenção & controle
Xylariales/química
Paullinia/microbiologia
Endófitos/química
Fungicidas Industriais/farmacologia
-Filogenia
Doenças das Plantas/microbiologia
Espectrometria de Massas
Xylariales/isolamento & purificação
Xylariales/genética
Xylariales/metabolismo
Estrutura Molecular
Colletotrichum/efeitos dos fármacos
Colletotrichum/fisiologia
Endófitos/isolamento & purificação
Endófitos/genética
Endófitos/metabolismo
Fungicidas Industriais/isolamento & purificação
Fungicidas Industriais/química
Responsável: BR1.1 - BIREME


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Id: lil-623974
Autor: Zhou, Bing-Nan.
Título: Some progress on the chemistry of natural bioactive terpenoids form Chinese medicinal plants
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):219-226, 1991. ilus, graf.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: (1) Pseudolaric acids - Novel diterpenes, Pseudolaric acid A, B, C and D were isolated from Pseudolarix kaempferi Gorden (pinaceae). Their structures were assigned by spectroscopic data and chemical correlations. In the contineous studies, the absolute configurations, the conformations in the solutions, the framentation mechanisms of MS and assigments of all NMR spectral signals were also reported. They showed the antifungal and cytotoxic activities. (2) Daphnane diterpenes - In the further studies on the plants of Thymelaeaceae, besides 10 known diterpenes, 16 new daphnane diterpenes were isolated from Daphne genkwa, D. tangutica, D. giraldii, Wikstroemie chamaedaphne. They showed the antifertilities activities. (3) Tripterygium diterpenes 14 new diterpenes were isolated from Triperygium wilfordii, T. regeli and T. hypoglaucum. Some of them showed the antitumor activities. The CD spectra showed that A/B ring of all compoundshave trans configuration as same as tripdiolide and triptolide determined by X-ray diffraction (4) Pregnane glycosides from Marsdenia koi - Two new pregnane glycosides marsdenikoiside A and marsdenikoiside B which can terminate the early pregnancy were isolated from Marsdeia koi. Their structures were elucidated by hydrolysis and spectroscopic methods.
Descritores: Relação Estrutura-Atividade
Medicamentos de Ervas Chinesas/química
Anticoncepcionais/isolamento & purificação
Anticoncepcionais/uso terapêutico
Diterpenos/isolamento & purificação
/química
FRUITTEMEFOS/química
-Espectroscopia de Ressonância Magnética
Estrutura Molecular
Conformação Molecular
Limites: Humanos
Responsável: BR1.1 - BIREME


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Lorenzetti, B. B
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Id: lil-623955
Autor: Oliveira, A. B de; Silva, T. H. A; Ferreira, S. H; Lorenzetti, B. B.
Título: Quaternary ammonium salt derivatives of allylphenols with peripheral analgesic effect
Fonte: Mem. Inst. Oswaldo Cruz;86(supl.2):133-136, 1991. ilus, tab.
Idioma: en.
Conferência: Apresentado em: Brazilian-Sino Symposium on Chemistry and Pharmacology of Natural Products, Rio de Janeiro, Dec. 10-14, 1989.
Resumo: Ammonium salt derivatives of natural allylphenols were synthesized with the purpose of obtaining potential peripheral analgesics. These drugs, by virtue of their physicochemical properties, would not be able to cross the blood brain barrier. Their inability to enter into the central nervous system (CNS) should prevent several adverse effects observed with classical opiate analgesics (Ferreira et al., 1984). Eugenol (1) O-methyleugenol (5) and safrole (9) were submitted to nitration, reduction and permethylation, leading to the ammonium salts 4, 8 and 12. Another strategy applied to eugenol (1), consisting in its conversion to a glycidic ether (13), opening the epoxide ring with secondary amines and methylation, led to the ammonium salts 16 and 17. All these ammonium salts showed significant peripheral analgesic action, in modified version of the Randall-Sellito test (Ferreira et al. 1978), at non-lethal doses. The ammonium salt 8 showed an activity comparable to that of methylnalorphinium, the prototype of an ideal peripheral analgesic (Ferreira et al., 1984).
Descritores: Safrol/síntese química
Safrol/farmacologia
Safrol/farmacocinética
Eugenol/análogos & derivados
Eugenol/síntese química
Compostos de Amônio/síntese química
Compostos de Amônio Quaternário/síntese química
Compostos de Amônio Quaternário/farmacologia
Analgésicos/síntese química
Analgésicos/farmacologia
Analgésicos/farmacocinética
-Medição da Dor
Estrutura Molecular
Ratos Wistar
Limites: Animais
Masculino
Camundongos
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-889127
Autor: Jiang, Cheng; Song, Jinzhu; Zhang, Junzheng; Yang, Qian.
Título: New production process of the antifungal chaetoglobosin A using cornstalks
Fonte: Braz. j. microbiol;48(3):410-418, July-Sept. 2017. tab, graf.
Idioma: en.
Projeto: National High Technology Research and Development Program; . \"Twelfth Five-Year Plan\" National Science and Technology Program on Rural Area.
Resumo: Abstract Chaetoglobosin A is an antibacterial compound produced by Chaetomium globosum, with potential application as a biopesticide and cancer treatment drug. The aim of this study was to evaluate the feasibility of utilizing cornstalks to produce chaetoglobosin A by C. globosum W7 in solid-batch fermentation and to determine an optimal method for purification of the products. The output of chaetoglobosin A from the cornstalks was 0.34 mg/g, and its content in the crude extract was 4.80%. Purification conditions were optimized to increase the content of chaetoglobosin A in the crude extract, including the extract solvent, temperature, and pH value. The optimum process conditions were found to be acetone as the extractant, under room temperature, and at a pH value of 13. Under these conditions, a production process of the antifungal chaetoglobosin A was established, and the content reached 19.17%. Through further verification, cornstalks could replace crops for the production of chaetoglobosin A using this new production process. Moreover, the purified products showed great inhibition against Rhizoctonia solani, with chaetoglobosin A confirmed as the main effective constituent (IC50 = 3.88 µg/mL). Collectively, these results demonstrate the feasibility of using cornstalks to synthesize chaetoglobosin A and that the production process established in this study was effective.
Descritores: Microbiologia Industrial/métodos
Calosidades/microbiologia
Chaetomium/metabolismo
Alcaloides Indólicos/metabolismo
Antifúngicos/metabolismo
-Resíduos/análise
Microbiologia Industrial/instrumentação
Calosidades/metabolismo
Estrutura Molecular
Caules de Planta/metabolismo
Caules de Planta/microbiologia
Alcaloides Indólicos/isolamento & purificação
Alcaloides Indólicos/química
Antifúngicos/isolamento & purificação
Antifúngicos/química
Tipo de Publ: Estudo de Avaliação
Responsável: BR1.1 - BIREME



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