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Pesquisa : G02.111.570.080.708.330.330 [Categoria DeCS]
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Texto completo SciELO Chile
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Id: biblio-838972
Autor: Espinoza, Rodrigo A; Silva-Valenzuela, Cecilia A; Amaya, Fernando A; Urrutia, Ítalo M; Contreras, Inés; Santiviago, Carlos A.
Título: Differential roles for pathogenicity islands SPI-13 and SPI-8 in the interaction of Salmonella Enteritidis and Salmonella Typhi with murine and human macrophages
Fonte: Biol. Res;50:5, 2017. tab, graf.
Idioma: en.
Projeto: FONDECYT; . FONDECYT; . CONICYT; . CONICYT; . CONICYT.
Resumo: BACKGROUND: Salmonella pathogenicity island (SPI)-13 is conserved in many serovars of S. enterica, including S. Enteritidis, S. Typhimurium and S. Gallinarum. However, it is absent in typhoid serovars such as S. Typhi and Paratyphi A, which carry SPI-8 at the same genomic location. Because the interaction with macrophages is a critical step in Salmonella pathogenicity, in this study we investigated the role played by SPI-13 and SPI-8 in the interaction of S. Enteritidis and S. Typhi with cultured murine (RAW264.7) and human (THP-1) macrophages. RESULTS: Our results showed that SPI-13 was required for internalization of S. Enteritidis in murine but not human macrophages. On the other hand, SPI-8 was not required for the interaction of S. Typhi with human or murine macrophages. Of note, the presence of an intact copy of SPI-13 in a S. Typhi mutant carrying a deletion of SPI-8 did not improve its ability to be internalized by, or survive in human or murine macrophages. CONCLUSIONS: Altogether, our results point out to different roles for SPI-13 and SPI-8 during Salmonella infection. While SPI-13 contributes to the interaction of S. Enteritidis with murine macrophages, SPI-8 is not required in the interaction of S. Typhi with murine or human macrophages. We hypothesized that typhoid serovars have lost SPI-13 and maintained SPI-8 to improve their fitness during another phase of human infection.
Descritores: Salmonella enteritidis/genética
Infecções por Salmonella/microbiologia
Salmonella typhi/genética
Ilhas Genômicas/fisiologia
Macrófagos/microbiologia
-Especificidade da Espécie
Sobrevivência Celular
Células Cultivadas
Reação em Cadeia da Polimerase
Análise de Variância
Genoma Bacteriano
Fenômenos Fisiológicos Bacterianos
Ilhas Genômicas/genética
Interações Microbianas/genética
Sorogrupo
Células RAW 264.7
Muridae
Limites: Humanos
Animais
Camundongos
Responsável: CL1.1 - Biblioteca Central


  2 / 21 LILACS  
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Texto completo SciELO Chile
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Id: biblio-1013789
Autor: Ulloa, María Teresa; Sanhueza, Camila; Henríquez, Tania; Aguayo, Benjamín; Hermosilla, Germán; Porte, Lorena; Dabanch, Jeannette; Braun, Stephanie; Fica, Alberto; Briceño, Isabel; Osorio, Carlos Gonzalo.
Título: Cepas chilenas de origen clínico de Vibrio cholerae no-O1, no-O139 portan los genes vcsN2, vcsC2, vcsV2, vspD, toxR2 y vopF del sistema de secreción T3SS2 presentes en una isla de patogenicidad / Chilean strains of clinical origin of non-O1, non-O139 Vibrio cholerae carry the genes vcsN2, vcsC2, vcsV2, vspD, toxR2 y vopF from secretion system T3SS2 present in an island of pathogenicity
Fonte: Rev. chil. infectol;36(3):312-317, jun. 2019. tab, graf.
Idioma: es.
Resumo: Resumen Introducción. Los factores de virulencia de las cepas de Vibrio cholerae no-O1, no-O139 no son claramente conocidos. La cepa de origen septicémico NN1 Vibrio cholerae no-O1, no-O139 fue secuenciada previamente mediante la plataforma Illumina, detectándose en su genoma un fragmento de la isla de patogenicidad VPaI-7 de V. parahaemolyticus. Objetivo: detectar los genes de virulencia vcsN2, vcsC2, vcsV2, vspD, toxR2 y vopF en cepas chilenas clínicas de V. cholerae no-O1, no-O139. Material y Métodos: Un total de 9 cepas chilenas de origen clínico de Vibrio cholerae no-O1, no-O139 aisladas entre 2006-2012 fueron analizadas mediante ensayos de reacción de polimerasa en cadena (RPC, en inglés PCR) convencional para los genes de secreción tipo III codificados en dicha isla: vcsN2, vcsC2, vcsV2, vspD, toxR2 y vopF. Adicionalmente se determinó la presencia de los genes de virulencia hylA y rtxA. Además, se realizaron ensayos de repetitive element palindromic PCR (REP-PCR) y Enterobacterial repetitive intergenic consensus PCR (ERIC-PCR). Resultados: la mayoría (6/9) de las cepas chilenas de V. cholerae no-O1, no-O139 contiene todos los genes de secreción tipo III vcsN2, vcsC2, vcsV2, vspD, toxR2 y vopF, codificados en una isla de patogenicidad. Además, el total de las cepas (9/9) contiene los genes de virulencia hylA y rtxA. Conclusión: Estos resultados sugieren fuertemente la posibilidad que dichas cepas posean un potencial de virulencia importante en seres humanos.

Backgound: The virulence factors of the Vibrio cholerae non-O1, non-O139 strains are not clearly known. The strain of septicemic origin NN1 Vibrio cholerae non-O1, non-O139 was sequenced previously by the Illumina platform. A fragment of the pathogenicity island VPaI-7 of V. parahaemolyticus was detected in its genome. Aim: To detect the virulence genes vcsN2, vcsC2, vcsV2, vspD, toxR2 y vopF in Chilean strains of V. cholerae non-O1, non-O139. Methods: A total of 9 Chilean strains of clinical origin of Vibrio cholerae non-O1, non-O139 isolated between 2006-2012 were analyzed by conventional PCR assays for type III secretion genes encoded on that island: vcsN2, vcsC2, vcsV2, vspD, toxR2 and vopF. Additionally, the presence of the virulence genes hylA and rtxA was determined. In addition, REP-PCR and ERIC-PCR assays were performed. Results: most (6/9) Chilean V. cholerae non-O1, non-O139 strains contain the type III secretion genes vcsN2, vcsC2, vcsV2, vspD, toxR2 and vopF, encoded in an island of pathogenicity. In addition, all (9/9) the strains contain the virulence genes hylA and rtxA. Conclusion: These results strongly suggest the possibility that those strains possess an important virulence potential in humans.
Descritores: Proteínas de Bactérias/genética
Fatores de Transcrição/genética
Vibrio cholerae/genética
Fatores de Virulência/genética
Vibrio cholerae não O1/genética
Ilhas Genômicas/genética
Proteínas de Ligação a DNA/genética
Sistemas de Secreção Tipo III/genética
-Toxinas Bacterianas/genética
Vibrio cholerae/isolamento & purificação
Vibrio cholerae/patogenicidade
Chile
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
Vibrio cholerae não O1/isolamento & purificação
Vibrio cholerae não O1/patogenicidade
Proteínas Hemolisinas/genética
Limites: Humanos
Responsável: CL1.1 - Biblioteca Central


  3 / 21 LILACS  
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Texto completo SciELO Chile
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Id: biblio-1013799
Autor: Olivares, Felipe; Domínguez, Ignacio; Dabanch, Jeannette; Porte, Lorena; Ulloa, M. Teresa; Osorio, Gonzalo.
Título: Bacteriemia por Vibrio cholerae no-O1/no-O139 que porta una región homóloga a la isla de patogenicidad VpaI-7 / Bacteremia caused by Vibrio cholerae non-O1/non-O139 carrying a region homologous to pathogenicity island VpaI-7
Fonte: Rev. chil. infectol;36(3):392-395, jun. 2019. tab, graf.
Idioma: es.
Resumo: Resumen Presentamos un caso de bacteriemia por Vibrio cholerae no-O1/ no-O139 en una mujer de 81 años con un cuadro de dolor abdominal, fiebre, vómitos, diarrea, coluria e ictericia, mientras visitaba una zona rural sin acceso a agua potable. La identificación se realizó por la técnica de espectrometría de masa MALDI-TOF, confirmándose una cepa no toxigénica no-O1/no-139. La caracterización molecular del aislado demostró la ausencia del gen de la toxina del cólera (CTX), y pilus TCP; sin embargo, presentó cinco de los seis genes de virulencia presentes en la isla de patogenicidad homóloga denominada VPaI-7 del V. parahaemolyticus (vcs N2+, vcs C2+, vcs V2+,toxR-, vspD+, T vopF+). Además, el aislado presentó los genes de virulencia hylA y rtxA. Este es el primer caso reportado en Chile de una cepa clínica de V. cholerae no-O1, no-O139 aislada de hemocultivos portador de un segmento homólogo de la isla de patogenicidad denominada VPaI-7 de V. parahaemolyticus, el cual codifica para un sistema de secreción tipo III (TTSS), que probablemente contribuye a su virulencia.

We report a case of V. cholerae non-O1 / non-O139 bacteremia in an 81-year-old woman with abdominal pain, fever, vomiting, liquid stools, choluria and jaundice, while visiting a rural area without access to potable water. The identification was made by the MALDI-TOF mass spectrometry technique and subsequently the non-toxigenic non-O1 / non-139 strain was confirmed in the national reference laboratory. The molecular characterization demonstrated the absence of the cholera toxin gene (CTX), and the TCP pilus, however, presented 5 of 6 virulence genes present in an island of homologous pathogenicity named VPaI-7 of V. parahaemolyticus (vcs N2 +, vcs C2 +, vcs V2 +, toxR-, vspD +, T vopF +) and in addition it was positive for hylAy rtxA virulence genes recognized outside the island. This is the first case reported in Chile of a clinical strain of V. cholerae non-O1, non-O139 isolated from blood culture that carries in its genome a homologous segment of the pathogenicity island named VPaI-7 of V. parahaemolyticus, which codifies for a type III secretion system (TTSS) that probably contributes to his virulence.
Descritores: Proteínas de Bactérias/química
Vibrio cholerae/química
Bacteriemia/etiologia
Vibrio cholerae não O1/química
-Proteínas de Bactérias/isolamento & purificação
Vibrio cholerae/isolamento & purificação
Vibrio cholerae/patogenicidade
Virulência
Cólera/complicações
Cólera/microbiologia
Espectrometria de Massas por Ionização e Dessorção a Laser Assistida por Matriz
Vibrio cholerae não O1/isolamento & purificação
Vibrio cholerae não O1/patogenicidade
Ilhas Genômicas
Limites: Humanos
Feminino
Idoso de 80 Anos ou mais
Tipo de Publ: Relatos de Casos
Responsável: CL1.1 - Biblioteca Central


  4 / 21 LILACS  
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Texto completo SciELO Chile
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Id: biblio-1042675
Autor: Osorio A, Gonzalo.
Título: Nota aclaratoria: Vibrio cholerae no-O1/no-O139 que porta una región homóloga a la isla de patogenicidad VpaI-7 / Disclaimer: Vibrio cholerae non-O1, non-O139 that carries a homologous segment of the pathogenicity island named VPaI-7
Fonte: Rev. chil. infectol;36(4):543-543, ago. 2019.
Idioma: es.
Descritores: Vibrio cholerae não O1
-Proteínas de Bactérias/genética
Virulência
Chile
Ilhas Genômicas
Tipo de Publ: Comentário
Carta
Responsável: CL1.1 - Biblioteca Central


  5 / 21 LILACS  
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Timm, Claudio Dias
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Id: lil-688195
Autor: Fortes, Tanise Pacheco; Fagundes, Michel Quevedo; Vasconcellos, Flávia Aleixo; Timm, Cláudio Dias; Silva, Éverton Fagonde da.
Título: Ilhas de patogenicidade de Salmonella enterica: uma revisão / Salmonella enterica pathogenicity islands: a review
Fonte: Rev. Inst. Adolfo Lutz;71(2):219-227, abr.-jun. 2012.
Idioma: pt.
Resumo: Salmonella é um bom modelo bacteriano para o estudo das interações entre hospedeiro e agente patogênico. Embora muitos de seus fatores de virulência tenham sido caracterizados, os mecanismos de especificidade aos hospedeiros com o desfecho na doença não estão elucidados. As ilhas de patogenicidade (PAI) são elementos genéticos dos cromossomos de um amplo número de agentes patogênicos. Nas salmonelas, muitos dos fatores de virulência são codificados por genes presentes nas PAI, as quais são referidos como ilhas de patogenicidade da Salmonella (SPI). Nesta revisão, são sumarizados os relatos na literatura específica dos últimos vinte anos sobre o papel das SPI na patogenia da doença e como elas influenciamnos mecanismos envolvidos na invasão e colonização das bactérias patogênicas no hospedeiro.
Descritores: Ilhas Genômicas
Infecções por Salmonella
Literatura de Revisão como Assunto
Salmonella enterica
Virulência
Responsável: BR76.1 - Biblioteca


  6 / 21 LILACS  
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Texto completo SciELO Cuba
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Id: biblio-1094616
Autor: Velasco-Carrillo, Judith; Araque-Granados, María; Ayala-Serrano, Juan; Dávila-Vera, Delsy; Peña-Contreras, Zulma; Mendoza-Briceño, Rosa.
Título: Patogenia de mutantes de Salmonella Typhimurium en dos modelos experimentales in vivo / Pathogenesis of Salmonella Typhimurium mutants in two experimental models in vivo
Fonte: Vaccimonitor (La Habana, Print);28(1), ene.-abr. 2019. tab, graf.
Idioma: es.
Resumo: Con la finalidad de evaluar la patogenia en cepas de Salmonella Typhimurium con mutaciones en los genes invG/invE de la Isla de Patogenicidad de Salmonella 1 (SPI-1) y de los genes ssaJ/ssaK en la SPI-2, se evaluaron los modelos asa intestinal ligada de ratón asociado a la observación de los tejidos por microscopía electrónica de transmisión (MET) y la producción de salmonelosis sistémica en ratón. Para ello, se utilizaron seis cepas de Salmonella: S. Typhimurium SL-1344 (cepa control) y sus derivadas mutantes: ∆invEG S. Typhimurium SL-1344 (mutante en SPI-1) y ∆ssaJK S. Typhimurium SL-1344 (mutante en SPI-2), S. Typhimurium (cepa clínica) y sus derivadas mutantes: ∆invEG S. Typhimurium y ∆ssaJK S. Typhimurium. Los resultados de MET permitieron verificar las alteraciones morfológicas del epitelio intestinal en el ratón infectado con cepas de Salmonella cuyos genes de patogenicidad estaban intactos. Fue comprobada la pérdida del poder invasivo solo en las cepas mutadas en la SPI-1. A través del modelo de salmonelosis sistémica en ratón se pudo comprobar la pérdida de la capacidad de diseminación en ambas mutantes. En conclusión los modelos permitieron verificar la importancia que tienen los genes invG/invE de la SPI-1 y ssaJ/ssaK de la SPI-2 en la patogenia de la salmonelosis, utilizando como modelo experimental de infección ratones BALB/c. Se sugieren estos modelos in vivo para evaluar mutantes de genes implicados en la patogenia de Salmonella, ya que representan una herramienta importante para la comprensión de la interacción Salmonella-hospedero(AU)

With the aim of evaluate the pathogenesis in Salmonella Typhimurium strains with mutations in genes invG/invE of Salmonella Pathogenicity Island 1 (SPI-1) and genes ssaJ/ssaK in the SPI-2 models were evaluated ligated intestinal loop associated mouse tissues by observation by transmission electron microscopy (TEM) and the production of mouse systemic salmonellosis. For this, we used six Salmonella strains: S. Typhimurium SL-1344 (control strain) and its derived mutants: ΔinvEG S. Typhimurium SL-1344 (mutant in SPI-1) and ΔssaJK S. Typhimurium SL-1344 (mutant in SPI-2), S. Typhimurium (clinical isolate) and its derived mutants: ΔinvEG S.Typhimurium and ΔssaJK S. Typhimurium. TEM results allowed us to verify the morphological alterations of the intestinal epithelium in mice infected with Salmonella strains whose pathogenicity genes were intact. It was proven invasive power loss only in strains mutated in the SPI-1. Through systemic salmonellosis model mouse we noted the loss of the ability to spread in both mutants. In conclusion, the models allowed us to verify the importance of the invG/invE genes of SPI-1 and ssaJ/ssaK of SPI-2 in the pathogenesis of salmonellosis, using BALB/c mice as an experimental model of infection. These in vivo models are suggested to evaluate mutants of genes involved in the pathogenesis of Salmonella, since they represent an important tool for the understanding of the Salmonella-host interaction(AU)
Descritores: Salmonella typhimurium/patogenicidade
Ilhas Genômicas/genética
Microscopia Eletrônica de Transmissão/métodos
Mutação/genética
Limites: Animais
Camundongos
Responsável: CU1.1 - Biblioteca Médica Nacional


  7 / 21 LILACS  
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Texto completo SciELO Brasil
Barth, Afonso Luís
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Id: biblio-828193
Autor: Pagano, Mariana; Martins, Andreza Francisco; Barth, Afonso Luis.
Título: Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
Fonte: Braz. j. microbiol;47(4):785-792, Oct.-Dec. 2016. tab.
Idioma: en.
Resumo: Abstract Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences.
Descritores: DNA Bacteriano
Elementos de DNA Transponíveis
Carbapenêmicos/farmacologia
Resistência beta-Lactâmica
Acinetobacter baumannii/efeitos dos fármacos
Acinetobacter baumannii/genética
Antibacterianos/farmacologia
-Mutagênese Insercional
Integrons
Ilhas Genômicas
Responsável: BR1.1 - BIREME


  8 / 21 LILACS  
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Texto completo SciELO Brasil
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Id: biblio-839380
Autor: Yuan, Xiao-yan; Yan, Jin-Jun; Yang, Ya-chao; Wu, Chun-mei; Hu, Yan; Geng, Jian-li.
Título: Helicobacter pylori with East Asian-type cagPAI genes is more virulent than strains with Western-type in some cagPAI genes
Fonte: Braz. j. microbiol;48(2):218-224, April.-June 2017. tab, graf.
Idioma: en.
Projeto: Shandong Provincial Natural Science Foundation; . Jiangsu Key Laboratory of Medical Science and Laboratory Medicine.
Resumo: Abstract The severity of Helicobacter pylori-related disease is correlated with the presence and integrity of a cag pathogenicity island (cagPAI). cagPAI genotype may have a modifying effect on the pathogenic potential of the infecting strain. After analyzing the sequences of cagPAI genes, some strains with the East Asian-type cagPAI genes were selected for further analysis to examine the association between the diversity of the cagPAI genes and the virulence of H. pylori. The results showed that gastric mucosal inflammatory cell infiltration was significantly higher in patients with East Asian-type cagPAI genes H. pylori strain compared with mosaicism cagPAI genes H. pylori strain (p < 0.05). H. pylori strains with the East Asian-type cagPAI genes were closely associated with IL-8 secretion in vitro and in vivo compared with H. pylori strains with the mosaicism cagPAI genes (p < 0.01). H. pylori strains with East Asian-type cagPAI genes are able to strongly translocate CagA to host cells. These results suggest that H. pylori strains with East Asian-type cagPAI genes are more virulent than the strains of cagPAI gene/genes that are Western type.
Descritores: Helicobacter pylori/classificação
Helicobacter pylori/genética
Infecções por Helicobacter/microbiologia
Infecções por Helicobacter/patologia
Ilhas Genômicas
Genótipo
-Filogenia
Virulência
Análise por Conglomerados
Helicobacter pylori/isolamento & purificação
Fatores de Virulência/genética
Mucosa Gástrica/patologia
Histocitoquímica
Microscopia
Limites: Humanos
Responsável: BR1.1 - BIREME


  9 / 21 LILACS  
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Texto completo SciELO Brasil
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Id: lil-705266
Autor: Ozbey, Gokben; Demirel, Ulvi; Aygun, Cem; Ertas, Hasan Basri.
Título: Investigation of the association between clinical outcome and the cag pathogenicity-island and other virulence genes of Helicobacter pylori isolates from patients with dyspepsia in Eastern Turkey
Fonte: Braz. j. microbiol;44(4):1267-1274, Oct.-Dec. 2013. tab.
Idioma: en.
Resumo: The aims of our work were to determine the presence of the cag pathogenicity-island (cag PAI) and other virulence genes of Helicobacter pylori recovered from patients with gastritis and peptic ulcer, and to investigate the correlation of these virulence genes with clinical outcome. The presence of the cagA, the promoter regions of cagA, cagE, cagT, and the left end of cag-PAI (LEC), cag right junction (cagRJ), the plasticity region open reading frames (ORFs), vacA and oipA genes among 69 H. pylori isolates were determined by polymerase chain reaction. Intact cag PAI was detected in only one (1.4%) isolate. The cagA gene was identified in 52.1% and 76.2% of isolates from patients with dyspepsia (gastritis and peptic ulcer), respectively. The plasticity region ORFs i.e. JHP912 and JHP931 were predominantly detected in isolates from peptic ulcer. Less than 25% of the isolates carried other ORFs. Types I, II and III were the most commonly found among the isolates. None of the isolates possessed type Ib, 1c, IIIb, IV and V motifs. The most commonly vacA genotypes were s1am1a and s1m2 in isolates with peptic ulcer and gastritis, respectively. The results confirmed that the prevalence of oipA (Hp0638) gene was 75% and 85.7% in patients with gastritis and peptic ulcer, respectively. Furthermore, vacA s1am1a positivity was significantly related to peptic ulcer (p < 0.05).
Descritores: Dispepsia/microbiologia
Dispepsia/patologia
Ilhas Genômicas
Infecções por Helicobacter/microbiologia
Infecções por Helicobacter/patologia
Helicobacter pylori/genética
Fatores de Virulência/genética
-DNA Bacteriano/genética
Variação Genética
Genótipo
Helicobacter pylori/isolamento & purificação
Reação em Cadeia da Polimerase
Resultado do Tratamento
Turquia
Limites: Humanos
Responsável: BR1.1 - BIREME


  10 / 21 LILACS  
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Texto completo SciELO Chile
Texto completo
Id: lil-700399
Autor: Navarro, Claudio A; von Bernath, Diego; Jerez, Carlos A.
Título: Heavy Metal Resistance Strategies of Acidophilic Bacteria and Their Acquisition: Importance for Biomining and Bioremediation
Fonte: Biol. Res;46(4):363-371, 2013. ilus, tab.
Idioma: en.
Resumo: Microbial solubilizing of metals in acid environments is successfully used in industrial bioleaching of ores or biomining to extract metals such as copper, gold, uranium and others. This is done mainly by acidophilic and other microorganisms that mobilize metals and generate acid mine drainage or AMD, causing serious environmental problems. However, bioremediation or removal of the toxic metals from contaminated soils can be achieved by using the specific properties of the acidophilic microorganisms interacting with these elements. These bacteria resist high levels of metals by using a few "canonical" systems such as active efflux or trapping of the metal ions by metal chaperones. Nonetheless, gene duplications, the presence of genomic islands, the existence of additional mechanisms such as passive instruments for pH and cation homeostasis in acidophiles and an inorganic polyphosphate-driven metal resistance mechanism have also been proposed. Horizontal gene transfer in environmental microorganisms present in natural ecosystems is considered to be an important mechanism in their adaptive evolution. This process is carried out by different mobile genetic elements, including genomic islands (GI), which increase the adaptability and versatility of the microorganism. This mini-review also describes the possible role of GIs in metal resistance of some environmental microorganisms of importance in biomining and bioremediation of metal polluted environments such as Thiomonas arsenitoxydans, a moderate acidophilic microorganism, Acidithiobacillus caldus and Acidithiobacillus ferrooxidans strains ATCC 23270 and ATCC 53993, all extreme acidophiles able to tolerate exceptionally high levels of heavy metals. Some of these bacteria contain variable numbers of GIs, most of which code for high numbers of genes related to metal resistance. In some cases there is an apparent correlation between the number of metal resistance genes and the metal tolerance of each of these microorganisms. It is expected that a detailed knowledge of the mechanisms that these environmental microorganisms use to adapt to their harsh niche will help to improve biomining and metal bioremediation in industrial processes.
Descritores: Acidithiobacillus/efeitos dos fármacos
Biodegradação Ambiental
Betaproteobacteria/efeitos dos fármacos
Regulação Bacteriana da Expressão Gênica
Metais Pesados/farmacologia
-Adaptação Fisiológica
Acidithiobacillus/genética
Betaproteobacteria/genética
Ilhas Genômicas
Homeostase
Responsável: CL1.1 - Biblioteca Central



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