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Id: biblio-838974
Autor: Valenzuela, Carlos Y.
Título: Selective intra-dinucleotide interactions and periodicities of bases separated by K sites: a new vision and tool for phylogeny analyses
Fonte: Biol. Res;50:3, 2017. tab, graf.
Idioma: en.
Resumo: Direct tests of the random or non-random distribution of nucleotides on genomes have been devised to test the hypothesis of neutral, nearly-neutral or selective evolution. These tests are based on the direct base distribution and are independent of the functional (coding or non-coding) or structural (repeated or unique sequences) properties of the DNA. The first approach described the longitudinal distribution of bases in tandem repeats under the Bose-Einstein statistics. A huge deviation from randomness was found. A second approach was the study of the base distribution within dinucleotides whose bases were separated by 0, 1, 2... K nucleotides. Again an enormous difference from the random distribution was found with significances out of tables and programs. These test values were periodical and included the 16 dinucleotides. For example a high ¨positive¨ (more observed than expected dinucleotides) value, found in dinucleotides whose bases were separated by (3K + 2) sites, was preceded by two smaller ¨negative¨ (less observed than expected dinucleotides) values, whose bases were separated by (3K) or (3K + 1) sites. We examined mtDNAs, prokaryote genomes and some eukaryote chromosomes and found that the significant non-random interactions and periodicities were present up to 1000 or more sites of base separation and in human chromosome 21 until separations of more than 10 millions sites. Each nucleotide has its own significant value of its distance to neutrality; this yields 16 hierarchical significances. A three dimensional table with the number of sites of separation between the bases and the 16 significances (the third dimension is the dinucleotide, individual or taxon involved) gives directly an evolutionary state of the analyzed genome that can be used to obtain phylogenies. An example is provided.
Descritores: Filogenia
Sequência de Bases/genética
Genoma
Análise de Sequência de DNA/métodos
Nucleotídeos/genética
-Periodicidade
Células Procarióticas/química
Valores de Referência
Algoritmos
DNA Mitocondrial/genética
Distribuição de Qui-Quadrado
Colágeno/genética
HIV-1/genética
Evolução Molecular
Sequências de Repetição em Tandem
Estruturas Cromossômicas
Deriva Genética
Drosophila melanogaster/genética
Epistasia Genética/genética
Nucleotídeos/química
Limites: Humanos
Animais
Responsável: CL1.1 - Biblioteca Central


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Id: lil-739227
Autor: Martínez Ortiz, Carlos M; Sautié Castellanos, Miguel; Cuza Ferrer, Yordanka; Wisdom Viña, Yinette.
Título: Herramienta web para la clasificación de microsatélites polimórficos en genomas bacterianos / Web Tool for classfication of polymorphic microsatellites in bacteria genomes
Fonte: Rev. cuba. inform. méd;5(1), ene.-jun. 2013.
Idioma: es.
Resumo: Las secuencias repetidas en tándem, específicamente los mini y micro satélites, han demostrado ser muy eficaces en la clasificación de bacterias patogénicas como B. anthracis, M. tuberculosis y P. aeruginosa, entre otras. En humanos es manifiesta su participación estando relacionados con más de ochenta enfermedades, gran parte de ellas de tipo neurodegenerativas, musculares y algunos tipos de cáncer. La herramienta web que presentamos es el resultado de la detección computacional de estas secuencias en genomas bacterianos completos y su correspondiente anotación en la estructura genómica de acuerdo a las diferentes regiones donde estos se localizan. La herramienta tiene como fin primario brindar un sistema relacional que permita al investigador ubicar los microsatélites de diferentes especies bacterianas, con más de un genoma secuenciado para inferir su posible carácter polimórfico, dentro del contexto de la estructura genómica y así proveer un primer acercamiento al rol putativo que los microsatélites desempeñan desde el punto de vista funcional. La herramienta se puede aplicar no solo en estudios taxonómicos y epidemiológicos sino en la detección de posibles relaciones de estas secuencias con las funciones moleculares, procesos biológicos y, en última instancia, las diversas formas de evolución de estas especies. El sitio web brinda el servicio de consultas a la base de datos de microsatélites bacterianos de acuerdo al sistema de tablas relacionales y atributos propios de las mismas. Cuenta además con los servicios típicos de un sitio con estas características como: sistema de autenticación, foro, encuestas, enlaces y documentación sobre la metodología empleada y del tema en cuestión(AU)

The tandem repeat sequences, especially mini and microsatellites, have proven to be very effective in classification of pathogenic bacteria such as B. anthracis, M. tuberculosis and P. aeruginosa, among others. In human beings it is manifest its participation, being related with over eighty diseases, nearly all neurodegenerative and muscular, and some kinds of cancer. The web tool we are offering here is the result of computational detection of these sequences in whole bacteria genomes, and its respective annotation in the genomic structure according to the different regions where they are localized. The primary goal of this tool is to offer a relational system that allows mapping the microsatellites of bacterial species, all of them with more than one genome sequenced to infer their possible polymorphic character, in the context of genomic structure and thus providing a first approach to the putative role they perform from the functional point of view. The tool can be applied not only in taxonomical and epidemiological studies but in the detection of possible relationships of these sequences with the molecular functions, the biological processes and, as a last resort, the different forms of these species evolution. The web site offers the service of queries to the bacterial microsatellites database according to the related tables and its inherent attributes. It also has the typical services of this kind of site like: logging system, forum, polls, links and documentation about the employed methodology and the topic(AU)
Descritores: Bactérias
Repetições de Microssatélites/genética
Sequências de Repetição em Tandem/genética
Bases de Dados Genéticas
Limites: Humanos
Responsável: CU1.1 - Biblioteca Médica Nacional


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Id: lil-776495
Autor: Lochner, Christine; McGregor, Nathaniel; Hemmings, Sian; Harvey, Brian H; Breet, Elsie; Swanevelder, Sonja; Stein, Dan J.
Título: Symmetry symptoms in obsessive-compulsive disorder: clinical and genetic correlates
Fonte: Rev. bras. psiquiatr;38(1):17-23, Jan.-Mar. 2016. tab.
Idioma: en.
Resumo: Objective: In obsessive-compulsive disorder (OCD), symmetry-related symptoms may be important. Although clinical correlates of symmetry-related symptoms have been identified in OCD, few data exist on genetic associations. Animal studies indicate involvement of dopamine in symmetry-related behavior, suggesting this may be relevant to analogous symptoms in OCD. Alterations in dopamine may also reflect environmental influences. However, the association of symmetry-related symptomatology, early adversity, and polymorphisms in dopaminergic genes has not been investigated in OCD. Methods: Clinical information and polymorphisms in key dopaminergic genes were compared between OCD patients with primary symmetry symptoms and those without. Results: OCD patients with primary symmetry symptoms comprised 46.6% (n=210) of the sample (n=451), and were older (p < 0.01), had longer illness duration (p < 0.01), higher OCD severity scores (p = 0.01), and greater comorbidity (p < 0.01) than those without. In Caucasians (n=343), genotype frequency differed significantly between groups for ANKK1 rs1800497, with more OCD patients with symmetry symptoms being homozygous for the A2 (CC) genotype (χ2 = 7.296; p = 0.026). Conclusion: Symmetry symptoms have some distinct clinical features and may represent a marker of severity in OCD. However, clinical associations, in combination with the association found with the ANKK1 rs1800497 A2 variant, suggest that primary symmetry symptoms may represent a distinctive clinical and psychobiological profile.
Descritores: Dopamina/genética
Transtorno Obsessivo-Compulsivo/diagnóstico
Transtorno Obsessivo-Compulsivo/genética
-Polimorfismo Genético/genética
Transtornos de Estresse Pós-Traumáticos/complicações
Índice de Gravidade de Doença
Proteínas Serina-Treonina Quinases/genética
Sequências de Repetição em Tandem/genética
Transtorno Depressivo Maior/complicações
Perfeccionismo
Genótipo
Pessoa de Meia-Idade
Transtorno Obsessivo-Compulsivo/complicações
Limites: Humanos
Masculino
Feminino
Adolescente
Adulto
Adulto Jovem
Responsável: BR1.1 - BIREME


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Id: biblio-1095985
Autor: Santos, L. F. dos; Alvarez, J; Perez, A; Moreira, M. A. S; Pieters, M.
Título: Association of number of tandem repeats in two important adhesins in Mycoplasma hyopneumoniae / Associação entre os números de repetições em tandem em duas importantes adesinas de Mycoplasma hyopneumoniae
Fonte: Arq. bras. med. vet. zootec;67(5):1461-1464mapas.
Idioma: en.
Projeto: Capes Foundation, Ministry of Education of Brazil.
Resumo: Diversidade genética de Mycoplasma hyopneumoniae tem sido relatada em análise múltipla de repetições em tandem em número variável (MLVA). O objetivo deste estudo foi descrever a distribuição espacial e a heterogeneidade genética de tipos de M. hyopneumoniae no Brasil, bem como investigar a correlação entre regiões de repetição 1 (RR1) e 3 (RR3) de duas adesinas importantes (P97 e P146). Foram identificados 39 tipos de MLVA baseados no número de repetições em tandem em P97 RR1 e RR3 P146. A correlação negativa significativa (Spearman's rho = -0,26; P = 0,022) entre P97 RR1 e RR3 P146 foi observada, o que sugere um possível mecanismo compensatório que permitiria a bactéria manter a sua capacidade de adesão. Os resultados contribuem para compreender a epidemiologia das M. hyopneumoniae no quarto maior país produtor de suínos do mundo.(AU)
Descritores: Adesinas Bacterianas
Sequências de Repetição em Tandem
Mycoplasma hyopneumoniae/genética
Pneumonia Suína Micoplasmática/genética
-Suínos/microbiologia
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: biblio-834828
Autor: Moreno Valencia, Sandra P; Pineda Monsalve, Cielo R.
Título: Pruebas de paternidad mediante ADN / DNA paternity test
Fonte: Med. lab;20(9-10):411-432, 2014. tab, graf, ilus.
Idioma: es.
Resumo: La investigación científica de la paternidad biológica es un caso especial de la determinación de la relación genética entre dos o más individuos, con base en los principios de la herencia mendeliana simple de los marcadores genéticos, en los que se establecen que los alelos se segregan en la meiosis de forma independiente y discreta. En la evaluación de las relaciones biológicas forenses la prueba de paternidad es el análisis más común, en el cual los perfiles genéticos de dos individuos (o tres si la madre está disponible) son utilizados para comparar la probabilidad relativa de que uno de ellos sea el padre contra la probabilidad de no estar relacionado con la ascendencia del otro individuo analizado. En este caso las repeticiones cortas en tándem (STR) son los marcadores genéticos no ligados más utilizados para la evaluación del parentesco debido a su alto polimorfismo, y a que los resultados obtenidos, usualmente con la aplicación de estadísticas robustas, favorecen la determinación de la relación. Las repeticiones cortas en tándem son típicamente examinadas por la técnica de reacción en cadena de la polimerasa (PCR) mediante plataformas comerciales de múltiples loci de repeticiones cortas en tándem, eficientes y con gran poder de discriminación. Esta revisión describe el estado actual de las pruebas de paternidad mediante ADN, la metodología, el informe de los resultados y su interpretación, para facilitar su comprensión a los profesionales relacionados de una o de otra manera con estos análisis.

Scientific study of biological paternity is a special case of genetic relationship determinationbetween individuals, based on simple mendelian inheritance principles of genetic markers, which establish that the alleles are segregate independently and discreetly during meiosis. The most common analysis of forensic biological relationships evaluation is the paternity test, which the genetic profiles of two individuals (or three if the mother is available) are uses to compare the relative probability of that one of them being the father against the probability of not is ancestrally related to the other analyzed individual. The short tandem repeats (STR) are the commonly used unlinked genetic markers for relationship evaluation due to their high polymorphism. Besides, the results usually favor the determinationof the relationship when a robust statistical analysis is applied. The short tandem repeats analysis is typically by the polymerase chain reaction (PCR), using multiple short tandem repeats loci on commercial platforms, which are efficient and with high discriminating power. This review describes the current state of DNA paternity test, the methodology, the results report, and the interpretation, to facilitate their understanding to related professionals with these types of analysis.
Descritores: Testes Genéticos
Paternidade
Reação em Cadeia da Polimerase
Sequências de Repetição em Tandem
Limites: Humanos
Tipo de Publ: Revisão
Responsável: CO373.9 - EDIMECO - Editora Médica Colombiana S.A.


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Aguiar, Paulo Ricardo Loss
Weimer, Tania de Azevedo
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Id: lil-789892
Autor: Silveira, Juliano Coelho da; Passos, Daniel Thompsen; Glanzner, Werner Giehl; Aguiar, Paulo Ricardo Loss; Moraes, José Carlos Ferrugem; Weimer, Tania de Azevedo.
Título: Genome association analysis for pregnancy status following parturition in crossbred beef cattle / Estudo de associação genômica de prenhez pós-parto em vacas de corte
Fonte: Braz. j. vet. res. anim. sci;50(5):406-413, 2013. tab.
Idioma: en.
Resumo: The aim of this study was to evaluate genetic diversity of nine molecular markers, six short tandem repeats - STRs (BM4325, BMS3004, ILSTS002, IDVGA51, HEL5, AFZ1) and three single nucleotide polymorphisms (SNPs; LepSau3A1 A-B, LepSau3A1 1-2, and FSHRAlu1), linked to genes involved in reproductive function and their possible effect on reproductive performance. For this purpose, 81 crossbred beef cows were used in this study. The animals were classified into two groups (fertile and sub-fertile cows) based on their pregnancy status after two breeding seasons. High genetic diversity level was observed highlighted by the polymorphic content information ranging 0.23 to 0.87 and expected heterozygosity from 27 to 89%, with an average of 62%. Alleles BM4325 103, BMS3004 129, ILSTS002 137, IDVGA51 177, LEPSau3A1 A, LEPSau3A1 1, HEL5 149, AFZ1 119 and FSHRAlu1 G presented high frequencies. Two STRs (IDVGA51 and ILSTS002), linked to Leptin and LH genes, respectively, were associated to reproductive performance. These data support previous findings suggesting the potential use of IDVGA51 and ILSTS002 STRs for reproductive performance selection.

Foi avaliada a diversidade genética de nove marcadores moleculares, dos quais seis do tipo short tandem repeats - STR (BM4325, BMS3004, ILSTS002, IDVGA51, HEL5, AFZ1) e três do tipo single nucleotide polymorphisms - SNPs (LepSau3A1 A-B, LepSau3A1 1-2 e FSHRAlu1), ligados a genes envolvidos na reprodução e seus efeitos na performance reprodutiva. Foram examinadas amostras de sangue de 81 vacas sem raça definida, os animais foram classificados em dois grupos (vacas férteis e subférteis) baseado nas taxas de prenhez de duas estações reprodutivas. Alto nível de diversidade genética foi observado, revelando alto conteúdo de informação polimórfica, variando de 0,23 a 0,87 e heterozigosidade esperada de 27 a 89% com 62% em média. Os alelos mais frequentes foram BM4325 103*, BMS3004 129*, ILSTS002 137*, IDVGA51 177*, LEPSau3A1 A, LEPSau3A1 1, HEL5 149*, AFZ1 119* e FSHRAlu1 G. Os marcadores IDVGA51 e ILSTS002, ligados aos genes da leptina e LH, respectivamente, foram associados a performance reprodutiva. Esses dados suportam achados prévios que sugerem o potencial uso desses marcadores na seleção de animais com maior performance reprodutiva.
Descritores: Hormônio Luteinizante Subunidade beta/genética
Leptina/genética
Polimorfismo de Nucleotídeo Único/genética
Sequências de Repetição em Tandem/genética
Variação Genética/genética
-Técnicas de Reprodução Assistida/veterinária
Limites: Animais
Feminino
Gravidez
Bovinos
Responsável: BR68.1 - Biblioteca Virginie Buff D'Ápice


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Id: lil-747152
Autor: AlNoury, Mohammed K.; Almuhayawi, Saad M.; Alghamdi, Khalid B.; Al-Noury, Khaled I..
Título: Preoperative Imaging Modalities to Predict the Risk of Regional Nodal Recurrence in Well-Differentiated Thyroid Cancers
Fonte: Int. arch. otorhinolaryngol. (Impr.);19(2):116-120, Apr-Jun/2015. tab.
Idioma: en.
Resumo: Introduction Thyroid cancer incidence has increased in the previous 2 decades. Preoperative identification of lymph node metastasis is a suggested risk factor associated with recurrence following thyroidectomy. Objectives We aimed to evaluate the accuracy of preoperative radiologic investigations of nodal status in determining the postoperative risk of regional nodal recurrence in cases of well-differentiated thyroid cancer. Methods This is a case series. We retrospectively reviewed data, including preoperative ultrasonography and/or computed tomography results, on patients who underwent total thyroidectomy for thyroid cancer at our hospital between 2006 and 2012. Prognostic factors for predicting recurrence, including age, sex, tumor diameter, and nodal diameter, were evaluated. Results Total thyroidectomy was performed on 24 male and 74 female patients (median age, 43 years). The median follow-up time was 21 months. Sixty-eight patients had papillary thyroid cancer, and 30 had follicular cancer. Nodal recurrence was evident in 30% of patients, and 4% of patients died. Identification of lymph node involvement during preoperative radiologic investigations was strongly prognostic for recurrence: 35.3% of patients with positive preoperative ultrasonography findings and 62.5% of those with positive preoperative computed tomography findings had recurrence (p = 0.01). Conclusions Preoperative identification of lymph node metastasis on radiologic studies was correlated with an increased risk of regional nodal recurrence in well-differentiated thyroid cancer. Computed tomography was superior to ultrasonography in detecting metastatic nodal involvement preoperatively and is therefore recommended for preoperative assessment and postoperative follow-up. .
Descritores: Hematopoese/genética
Leucemia Mieloide Aguda/genética
Proteínas de Peixe-Zebra/fisiologia
Peixe-Zebra/fisiologia
/fisiologia
FMS-LIKE TYROSINE KINASE ABATTOIRS/fisiologia
-Sequência de Aminoácidos
Animais Geneticamente Modificados
Sequência Conservada
Embrião não Mamífero
Dados de Sequência Molecular
Estrutura Terciária de Proteína/genética
Homologia de Sequência de Aminoácidos
Sequências de Repetição em Tandem
Transcriptoma
Proteínas de Peixe-Zebra/química
Peixe-Zebra/embriologia
/química
FMS-LIKE TYROSINE KINASE ABATTOIRS/química
Limites: Animais
Humanos
Tipo de Publ: Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-725670
Autor: Merzoni, Jóice; Ewald, Gisele Menezes; Paz, Alessandra Aparecida; Daudt, Liane Esteves; Jobim, Luiz Fernando Job.
Título: Quantification of mixed chimerism allows early therapeutic interventions
Fonte: Rev. bras. hematol. hemoter;36(5):369-372, Sep-Oct/2014. tab.
Idioma: en.
Resumo: Hematopoietic stem cell transplantation is the curative option for patients with myelodysplastic syndrome; however, it requires a long post-transplantation follow-up. A 53-year-old woman with a diagnosis of myelodysplastic syndrome underwent related donor allogeneic hematopoietic stem cell transplantation in July 2006. Three months after transplantation, a comparative short tandem repeat analysis between donor and recipient revealed full chimerism, indicating complete, healthy bone marrow reconstitution. Three years and ten months after hematopoietic stem cell transplantation, the patient developed leukopenia and thrombocytopenia. Another short tandem repeat analysis was carried out which showed mixed chimerism (52.62%), indicating relapsed disease. A donor lymphocyte infusion was administered. The purpose of donor lymphocyte infusion is to induce a graft-versus-leukemia effect; in fact, this donor's lymphocyte infusion induced full chimerism. Successive short tandem repeat analyses were performed as part of post-transplantation follow-up, and in July 2010, one such analysis again showed mixed chimerism (64.25%). Based on this finding, a second donor lymphocyte infusion was administered, but failed to eradicate the disease. In September 2011, the patient presented with relapsed disease, and a second related donor allogeneic hematopoietic stem cell transplantation was performed. Subsequent short tandem repeat analyses revealed full chimerism, indicating complete bone marrow reconstitution. We conclude that quantitative detection of mixed chimerism is an important diagnostic tool that can guide early therapeutic intervention...
Descritores: Transplante de Medula Óssea
Quimerismo
Doenças Mieloproliferativas-Mielodisplásicas
Sequências de Repetição em Tandem
Limites: Humanos
Tipo de Publ: Relatos de Casos
Responsável: BR408.1 - Biblioteca da Faculdade de Medicina - BFM


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Id: lil-723983
Autor: Peñuelas-Urquides, Katia; Martínez-Rodríguez, Herminia Guadalupe; Enciso-Moreno, José Antonio; Molina-Salinas, Gloria María; Silva-Ramírez, Beatriz; Padilla-Rivas, Gerardo Raymundo; Vera-Cabrera, Lucio; Torres-de-la-Cruz, Víctor Manuel; Martínez-Martínez, Yazmin Berenice; Ortega-García, Jorge Luis; Garza-Treviño, Elsa Nancy; Enciso-Moreno, Leonor; Saucedo-Cárdenas, Odila; Becerril-Montes, Pola; Said-Fernández/, Salvador.
Título: Correlations between major risk factors and closely related Mycobacterium tuberculosis isolates grouped by three current enotyping procedures: a population-based study in northeast Mexico
Fonte: Mem. Inst. Oswaldo Cruz;109(6):814-819, 09/09/2014. tab, graf.
Idioma: en.
Projeto: SALUD.
Resumo: The characteristics of tuberculosis (TB) patients related to a chain of recent TB transmissions were investigated. Mycobacterium tuberculosis (MTB) isolates (120) were genotyped using the restriction fragment length polymorphism-IS6110 (R), spacer oligotyping (S) and mycobacterial interspersed repetitive units-variable number of tandem repeats (M) methods. The MTB isolates were clustered and the clusters were grouped according to the similarities of their genotypes. Spearman’s rank correlation coefficients between the groups of MTB isolates with similar genotypes and those patient characteristics indicating a risk for a pulmonary TB (PTB) chain transmission were ana- lysed. The isolates showing similar genotypes were distributed as follows: SMR (5%), SM (12.5%), SR (1.67%), MR (0%), S (46.67%), M (5%) and R (0%). The remaining 35 cases were orphans. SMR exhibited a significant correlation (p < 0.05) with visits to clinics, municipalities and comorbidities (primarily diabetes mellitus). S correlated with drug consumption and M with comorbidities. SMR is needed to identify a social network in metropolitan areas for PTB transmission and S and M are able to detect risk factors as secondary components of a transmission chain of TB.
Descritores: Técnicas de Genotipagem/métodos
Mycobacterium tuberculosis/genética
Tuberculose Pulmonar/microbiologia
Tuberculose Pulmonar/transmissão
-Cidades
Comorbidade
DNA Bacteriano/isolamento & purificação
Genótipo
Sequências Repetitivas Dispersas/genética
Testes de Sensibilidade Microbiana
México/epidemiologia
Epidemiologia Molecular/métodos
Mycobacterium tuberculosis/classificação
Mycobacterium tuberculosis/isolamento & purificação
Polimorfismo de Fragmento de Restrição/genética
Fatores de Risco
Fatores Sociológicos
Estatísticas não Paramétricas
Sequências de Repetição em Tandem/genética
Tuberculose Pulmonar/epidemiologia
Tuberculose Pulmonar/genética
População Urbana
Limites: Adolescente
Adulto
Idoso
Idoso de 80 Anos ou mais
Feminino
Humanos
Masculino
Pessoa de Meia-Idade
Adulto Jovem
Tipo de Publ: Research Support, Non-U.S. Gov't
Responsável: BR1.1 - BIREME


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Id: lil-705823
Autor: Loffler, Sylvia Grune; Pavan, Maria Elisa; Vanasco, Bibiana; Samartino, Luis; Suarez, Olga; Auteri, Carmelo; Romero, Graciela; Brihuega, Bibiana.
Título: Genotypes of pathogenic Leptospira spp isolated from rodents in Argentina
Fonte: Mem. Inst. Oswaldo Cruz;109(2):163-167, abr. 2014. tab.
Idioma: en.
Projeto: Proyecto Nacional INTA.
Resumo: Leptospirosis is the most widespread zoonosis in the world and significant efforts have been made to determine and classify pathogenic Leptospira strains. This zoonosis is maintained in nature through chronic renal infections of carrier animals, with rodents and other small mammals serving as the most important reservoirs. Additionally, domestic animals, such as livestock and dogs, are significant sources of human infection. In this study, a multiple-locus variable-number tandem repeat analysis (MLVA) was applied to genotype 22 pathogenic Leptospira strains isolated from urban and periurban rodent populations from different regions of Argentina. Three MLVA profiles were identified in strains belonging to the species Leptospira interrogans (serovars Icterohaemorrhagiae and Canicola); one profile was observed in serovar Icterohaemorrhagiae and two MLVA profiles were observed in isolates of serovars Canicola and Portlandvere. All strains belonging to Leptospira borgpetersenii serovar Castellonis exhibited the same MLVA profile. Four different genotypes were isolated from urban populations of rodents, including both mice and rats and two different genotypes were isolated from periurban populations.
Descritores: Leptospira/genética
Roedores/microbiologia
-Argentina
Didelphis/microbiologia
Genótipo
Técnicas de Genotipagem/métodos
Leptospira interrogans serovar canicola/genética
Leptospira interrogans serovar icterohaemorrhagiae/genética
Leptospira interrogans serovar pomona/genética
Leptospira/classificação
Leptospira/isolamento & purificação
Leptospirose/transmissão
Sorogrupo
Sorotipagem
Sequências de Repetição em Tandem/genética
População Urbana
Virulência/genética
Limites: Animais
Camundongos
Ratos
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BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde