Base de dados : LILACS
Pesquisa : G02.211 [Categoria DeCS]
Referências encontradas : 46 [refinar]
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Id: biblio-1039046
Autor: Riaz, Muhammad Ijaz; Sarwar, Hafiz Shoaib; Rehman, Mubashir; Gohar, Umar Farooq; Raza, Syed Atif; Siddique, Muhammad Irfan; Shahnaz, Gul; Sohail, Muhammad Farhan.
Título: Study of erythrocytes as a novel drug carrier for the delivery of artemether
Fonte: Braz. J. Pharm. Sci. (Online);55:e17680, 2019. graf.
Idioma: en.
Resumo: Resealed erythrocytes have been explored in various dimensions of drug delivery, owing to their high biocompatibility and inability to initiate immune response. The present research was designed to evaluate the drug delivery potential of erythrocytes by loading a hydrophobic anti-malarial drug, Artemether. Three different loading techniques were applied to achieve maximum optimized drug loading. A HPLC method was validated for drug quantification in erythrocytes. The relatively high loading was achieved using hypotonic treatment was 31.39% as compared to other two methods. These, drug loaded erythrocytes were characterized for membrane integrity via ESR showing higher ESR values for drug loaded cells as compared to normal cells. Moreover, microscopic evaluation was done to observe morphological changes in erythrocytes after successful loading which showed swollen cells with slight rough surface as compared to smooth surface of normal cells. Drug release was studied for 8 h which showed more than 80% release within 3-7 h from erythrocytes treated with different hypotonic methods. Overall, the study revealed a potential application of erythrocytes in delivery of hydrophobic drugs using hypotonic treatment as compared to other methods.
Descritores: Eritrócitos/classificação
Liberação Controlada de Fármacos
/administração & dosagem
FRUCTOKINASESABBREVIATIONS AS TOPIC/administração & dosagem
-Preparações Farmacêuticas/administração & dosagem
Cromatografia Líquida de Alta Pressão/métodos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-998224
Autor: Martín Casanova-Godoy, Luis Antonio; Castillo-Saavedra, Ericson Félix; Reynoso-Leyva, Elva Milagros; Ayala-Jara, Carmen Isolina.
Título: Estudio comparativo de perfiles de disolución de tabletas de prednisona 20 mg comercializados en Perú / Comparative study of dissolution profiles of prednisone 20 mg tablets marketed in Peru
Fonte: Mem. Inst. Invest. Cienc. Salud (Impr.);16(3):13-21, dic. 2018. tab, ilus.
Idioma: es.
Resumo: El estudio tuvo como finalidad comparar los perfiles de disolución de tabletas de prednisona 20 mg comercializados en Perú. Se realizó un estudio cuantitativo comparativo con diseño no experimental, que incluyó doce tabletas para cada formulación a evaluar (referente y multifuente), bajo condiciones similares de trabajo, en tres medios de disolución: buffer ácido clorhídrico pH 1,2; buffer acetato pH 4,5 y buffer fosfato pH 6,8. Los porcentajes temporales disueltos de prednisona fueron evaluados mediante el orden cinético cero, uno, Higuchi, raíz cúbica y Weibull para el modelo dependiente; mientras que el factor de similitud (f2), tiempo medio de disolución y eficiencia de disolución fueron utilizados para el modelo independiente. En el modelo dependiente, la liberación de prednisona; se ajustó a la cinética de función de Weibull; evaluada mediante el criterio de información de Akaike. En el modelo independiente, los valores de f2 en todos los medios de disolución cumplieron con el rango 50 - 100 establecida por la Food and Drug Adminstration, para indicar similitud in vitro entre los perfiles de disolución. Asimismo, se evidenció que no existe diferencia estadísticamente significativa entre las formulaciones, respecto al tiempo medio de disolución y la eficiencia de disolución. Las tabletas de prednisona 20 mg referente y multifuente comercializados en Perú son similares, con base en pruebas de perfiles de disolución in vitro(AU)

The purpose of the study was to compare the dissolution profiles of prednisone 20 mg tablets marketed in Peru. A comparative quantitative study with a non-experimental design was carried out, which included twelve tablets for each formulation to be evaluated (referent and multi-source), under similar work conditions in three dissolution media: hydrochloric acid buffer pH 1.2, acetate buffer pH 4.5 and phosphate buffer pH 6.8. The dissolved temporal percentages of prednisone were evaluated by zero kinetic order and first kinetic order, Higuchi, cubic root and Weibull models for the dependent model; while the similarity factor (f2), mean dissolution time and dissolution efficiency were used for the independent model. In the dependent model, the release of prednisone was adjusted to the Weibull function kinetics, evaluated using the Akaike information criterion. In the independent model, the values of f2 in all the dissolution media fulfilled the range 50 - 100 established by the Food and Drug Administration, to indicate in vitro similarity between the dissolution profiles. Likewise, it was evidenced that there is no statistically significant difference between the formulations with respect to the mean dissolution time and the dissolution efficiency. The reference and multi-source prednisone 20 mg tablets marketed in Peru are similar based on in vitro dissolution profiles tests(AU)
Descritores: Prednisona/farmacocinética
Liberação Controlada de Fármacos
Glucocorticoides/farmacocinética
-Peru
Comprimidos
Técnicas In Vitro
Dissolução
Tipo de Publ: Estudo Comparativo
Responsável: PY3.1 - Biblioteca


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Id: biblio-951934
Autor: Montaña, Jorge Andrés; Perez, León Darío; Baena, Yolima.
Título: A pH-responsive drug delivery matrix from an interpolyelectrolyte complex: preparation and pharmacotechnical properties
Fonte: Braz. J. Pharm. Sci. (Online);54(2):e17183, 2018. tab, graf, ilus.
Idioma: en.
Projeto: COLCIENCIAS.
Resumo: ABSTRACT Interpolyelectrolyte complexes, which constitute a type of polymeric material obtained through the self-assembly of oppositely charged polymers, exhibit interesting properties for use in the design of smart matrices for drug delivery. In the present study, a stoichiometric interpolyelectrolyte complex (SIPEC) composed of Eudragit E® and Eudragit® L100 was obtained at pH 6.0 and characterized and evaluated as a hydrophilic matrix for dexibuprofen. The formation of a SIPEC was monitored by ζ-potential measurements and characterized using infrared spectroscopy, thermal analysis, and scanning electron microscopy. The results indicated that a SIPEC obtained under these conditions can be used as a matrix for controlling the release of dexibuprofen and exhibit a pH-triggered release
Descritores: Liberação Controlada de Fármacos
Concentração de Íons de Hidrogênio
-Tecnologia Farmacêutica/instrumentação
Anti-Inflamatórios/análise
Responsável: BR1.1 - BIREME


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Id: biblio-906735
Autor: Silva, Guilherme Barreto Garneiro; Costa Junior, José de Ribamar; Sousa, Amanda; Sousa, José Eduardo; Abizaid, Alexandre.
Título: Stents farmacológicos: estado atual / Drug-eluting stents: state-of-the-art
Fonte: Rev. Soc. Cardiol. Estado de Säo Paulo;28(1), jan.-mar. 2018. ilus.
Idioma: pt.
Resumo: Stents farmacológicos foram desenvolvidos para reduzir a resposta proliferativa neointimal e consequentemente a reestenose, mais frequente limitação da intervenção coronária percutânea com balão e stents não faramcológicos. O desenvolvimento destes dispositivos baseia-se no maior entendimento da biologia da reestenose, na seleção de fármacos anti-proliferativos adequados para os diversos mecanismos envolvidos nesta complicação e no uso de plataformas/polímeros adequados para entrega do fármaco. Consequentemente o desempenho destes dispositivos depende da perfeita interação de todos estes elementos. As abordagens atuais para minimizar a reestenose são revisados neste capítulo. Embora a primeira geração dos stents farmacológicos tenha sido focada na eficácia em reduzir a reestenose, questões relacionadas à sua segurança surgiram, comprometendo seu uso mais disseminado. As novas gerações de stents farmacológicos com polímeros duráveis ou bioabsorvíveis conseguiu reduzir as taxas de nova intervenção e de trombose. Embora o modelo ideal de stent farmacológico ainda esteja em investigação, é certo que esta tecnologia já se estabeleceu como primeira linha na intervenção coronária percutânea contemporânea
Descritores: Polímeros/uso terapêutico
Sirolimo
Reestenose Coronária
Stents Farmacológicos
-Doença da Artéria Coronariana
Stents
Liberação Controlada de Fármacos/efeitos dos fármacos
Everolimo
Revascularização Miocárdica/métodos
Limites: Humanos
Masculino
Feminino
Tipo de Publ: Revisão
Responsável: BR44.1 - Serviço de Biblioteca, Documentação Científica e Didática Prof. Dr. Luiz Venere Décourt


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Id: biblio-1001579
Autor: Shaheen, Nabeela; Zaman, Shahiq uz.
Título: Development of fast dissolving tablets of flurbiprofen by sublimation method and its in vitro evaluation
Fonte: Braz. J. Pharm. Sci. (Online);54(4):e17061, 2018. tab, graf.
Idioma: en.
Resumo: Flurbiprofen belongs to Biopharmaceutical Classification System (BCS) class II drugs which are poorly soluble in water. The objective of present research work was to prepare fast dissolving tablets of Flurbiprofen using varying concentrations of three different sublimating agents to improve the dissolution rate. Seven formulations were prepared containing different concentrations of camphor, ammonium bicarbonate and thymol as sublimating agent along with primogel as a superdisintegrant. Tablets were manufactured by direct compression method. The prepared tablets were evaluated for pre-compression and post-compression parameters result, For all formulations result was within official limits. FTIR studies revealed that there were no interactions between the drug and the excipients used. From in vitro drug release studies it was concluded that the formulations F6 and F7 containing 10% and 15% of thymol showed fast drug release of 100.00% and 100.84% respectively in 30 minutes. Formulations containing camphor (F2 & F3) and ammonium bicarbonate (F4 & F5) as sublimating agents showed a drug release of less than 80%, while the control formulation F1 having no sublimating agent showed 49.14% of drug release in 30 minutes. Thus thymol can successfully be used to formulate fast dissolving tablets of flurbiprofen by sublimation method with much better dissolution profile
Descritores: Comprimidos/farmacologia
Técnicas In Vitro
Flurbiprofeno/análise
Dissolução/análise
-Liberação Controlada de Fármacos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1001570
Autor: Shabbir, Maryam; Sajid, Ali; Hamid, Irfan; Sharif, Ali; Akhtar, Muhammad Furqan; Raza, Moosa; Ahmed, Shoaib; Peerzada, Sohaib; Amin, Muhammad Umair.
Título: Influence of different formulation variables on the performance of transdermal drug delivery system containing tizanidine hydrochloride: in vitro and ex vivo evaluations
Fonte: Braz. J. Pharm. Sci. (Online);54(4):e00130, 2018. tab, graf.
Idioma: en.
Resumo: The present study was aimed at preparation of transdermal patches of tizanidine HCl, evaluation of the effect of polymers on in vitro release pattern of the drug, and the effect of permeation enhancers on the penetration of the drug through the rabbit skin. Various proportions of hydrophilic (HPMC) and hydrophobic (Eudragit L-100) polymers were used with PEG 400 as film-forming agent, and Span 20 or DMSO as permeation enhancer. The formulations were assessed for physicochemical characteristics and in vitro drug release studies using USP paddle over disc method in phosphate buffered saline (pH 7.4) at 32.0±1°C. On the basis of in vitro studies and physicochemical evaluations, S03-A and S04-A were selected at Eudragit : HPMC ratios of 8 : 2 and 7 : 3, respectively, for further ex vivo analysis. The effects of different concentrations of Span 20 and DMSO were evaluated on excised rabbit skin using Franz diffusion cell. Cumulative drug permeation, flux, permeability coefficient, target flux, and enhancement ratio were calculated and compared with the control formulations. Kinetic models and Tukey's multiple comparison test were applied to evaluate the drug release patterns. Formulation SB03-PE containing Eudragit L-100:HPMC (7:3) with Span 20 (15% w/w) produced the highest enhancement in drug permeation, and followed zero order kinetic model with super case-II drug release mechanism.
Descritores: Adesivo Transdérmico/classificação
Adesivo Transdérmico/provisão & distribução
-Técnicas In Vitro
Preparações Farmacêuticas/análise
Interações Hidrofóbicas e Hidrofílicas
Liberação Controlada de Fármacos/efeitos dos fármacos
Limites: Animais
Coelhos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-1001565
Autor: Martins, Sarah Moherdaui; Müller, Vinicius; Galan, Vanderson; Souza, Fabio Pinheiro de; Andreazza, Itamar Francisco; Rosa, Maurício Ferreira da.
Título: Development and evaluation of multiparticulate biphasic system for the treatment of circadian diseases
Fonte: Braz. J. Pharm. Sci. (Online);54(4):e17167, 2018. tab, graf, ilus.
Idioma: en.
Resumo: Multiparticulate systems have biopharmaceutical advantages when compared to the monolithic systems, once they allow different patterns of drug release and can be used in different treatments. The aim of the present work was to develop a biphasic controlled release delivery system, using propranolol hydrochloride (PROP) that can be used for the treatment of circadian diseases. This system was obtained by the combination of cellulosic polymers hydroxypropyl methylcellulose (HPMC) and ethylcellulose (EC) in a 2² factorial experimental design, which allowed the optimization of the development stage. The pellets produced and used in biphasic formulations were evaluated for physical and chemical characteristics and presented acceptable results. The immediate fraction obtained showed the complete release in 30 min while the others kept the release of the drug for 24 h. This study showed that the combination of beads with different releasing characteristics allowed to obtain different release profiles, which can be modulated according to the pathological needs, especially with regard to circadian diseases that suffer alterations throughout the day.
Descritores: Projetos de Pesquisa
Cronoterapia/instrumentação
-Ritmo Circadiano
Liberação Controlada de Fármacos
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-951930
Autor: Haseeb, Muhammad Tahir; Bashir, Sajid; Hussain, Muhammad Ajaz; Ashraf, Muhammad Umer; Erum, Alia; Naeem-ul-Hassan, Muhammad.
Título: Acute toxicity study of a polysaccharide based hydrogel from linseed for potential use in drug delivery system
Fonte: Braz. J. Pharm. Sci. (Online);54(2):e17459, 2018. tab.
Idioma: en.
Resumo: ABSTRACT Linseed hydrogel (LSH) was evaluated by acute toxicity for its potential application in oral drug delivery design. White albino mice and rabbits were divided in four groups (I-IV) and different doses of LSH (1, 2 and 5 g/kg body weight) were given except to the control group (I) that was left untreated. Rabbits were monitored for eye irritation, acute dermal toxicity and primary dermal irritation, whereas, body weight, food and water consumption, hematology and clinical biochemistry, gross necropsy and histopathology of vital organs were scrutinized in mice. LSH was considered safe after eye irritation test as no adverse signs or symptoms were seen in the eye. In dermal toxicity and irritation study, skin of treated rabbits was found normal in color without any edema or erythema. After oral administration, there was no sign of any abnormalities in treated group animals (II-IV). The hematology and clinical biochemistry of treated group animals was comparable with the control group. Histopathology of vital organs has not shown any lesion or abnormalities. In the light of these outcomes, it can be concluded that LSH is not a hazardous biomaterial and could be incorporated as an excipient in oral and dermal preparations.
Descritores: Polissacarídeos
Linho/classificação
Hidrogel de Polietilenoglicol-Dimetacrilato/análise
Liberação Controlada de Fármacos
-Administração Oral
Testes de Toxicidade Aguda/métodos
Hematologia
Limites: Animais
Masculino
Feminino
Coelhos
Ratos
Responsável: BR1.1 - BIREME


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Id: biblio-889432
Autor: Tilkan, Müserref Günseli Yüksel; Özdemir, Nurten.
Título: Investigation of the parameters affecting the release of flurbiprofen from chitosan microspheres
Fonte: Braz. J. Pharm. Sci. (Online);53(4):e00242, 2017. tab, graf, ilus.
Idioma: en.
Resumo: ABSTRACT Flurbiprofen (FLB), a NSAID, widely used for preventing pain generally for arthritis or dental problems. In this study, FLB loaded chitosan microspheres were prepared by ionotropic gelation method. In this method, microspheres were formed by dropping chitosan solutions containing FLB into sodium alginate solutions including sodium tripolyphosphate (TPP). A variety of formulation parameters like drug:polymer ratio, drug concentration, polymer's molecular weight, polymer concentration, pH and the concentration of TPP solutions, drying method and stirring time were analyzed. The dissolution studies were performed in a shaking water bath in pH 7.4 phosphate buffer saline (PBS) at 37 °C. Laser diffractometer was used for particle size analysis, and scanning electron microscope (SEM) was used for morphological properties. Drug loading and loading efficiency were calculated by using UV spectrophotometer. The particles obtained were spherical with 0.7-1.3 mm size range, and the loading efficiency was approximately 21-79%. The dissolution studies conducted revealed that drug:polimer ratio and the polymer type and concentration affected the drug release from microspheres. It was observed that increasing the polymer concentration, polymer's molecular weight and TPP concentration decreased the FLB release from microspheres, which was according to Higuchi kinetics.
Descritores: Flurbiprofeno/análise
Quitosana/agonistas
Microesferas
-Liberação Controlada de Fármacos
Tipo de Publ: Técnicas In Vitro
Responsável: BR40.1 - DBD - Divisão de Biblioteca e Documentacão do Conjunto das Químicas


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Id: biblio-839492
Autor: Guerreiro, Luiz Henrique; Silva, Daniel da; Girard-Dias, Wendell; Mascarenhas, Camile Moreira; Miranda, Kildare; Sola-Penna, Mauro; Ricci Júnior, Eduardo; Lima, Luís Mauricio Trambaioli da Rocha e.
Título: Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study
Fonte: Braz. J. Pharm. Sci. (Online);53(2):e16039, 2017. tab, graf.
Idioma: en.
Resumo: ABSTRACT Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of proteins is particularly challenging due to their conformational instability. We have developed a micro-structured poly-epsilon-caprolactone (PCL) particle system loaded with human insulin using a simple double-emulsion w/o/w method followed by solvent evaporation method. This formulation is comprised by spheric-shaped microparticles with average size of 10 micrometers. In vitro release showed a biphasic behavior such as a rapid release with about 50% of drug delivered within 2 hours and a sustained phase for up to 48 h. The subcutaneous administration of microencapsulated insulin showed a biphasic effect on glycemia in streptozotocin-induced diabetic mice, compatible with short and intermediate-acting behaviors, with first transition peak at about 2 h and the second phase exerting effect for up to 48h after s.c. administration. This study reveals that a simplified double-emulsion system results in biocompatible human-insulin-loaded PCL microparticles that might be used for further development of optimized sustained release formulations of insulin to be used in the restoration of hormonal levels.
Descritores: Insulina/análise
-Preparações Farmacêuticas/administração & dosagem
Microscopia Eletrônica/estatística & dados numéricos
Diabetes Mellitus/prevenção & controle
Material Particulado/farmacologia
Liberação Controlada de Fármacos/fisiologia
Hipoglicemiantes/farmacologia
Limites: Animais
Masculino
Feminino
Camundongos
Tipo de Publ: Técnicas In Vitro
Responsável: BR1.1 - BIREME



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